Pericallosal Moustache Atherosclerosis

Pericallosal moustache atherosclerosis may sound like a mouthful, but it’s essential to understand this condition to protect your health. In simple terms, it refers to the buildup of fatty deposits in the blood vessels around the brain, particularly the pericallosal area, which resembles a moustache on medical imaging. Let’s dive into what causes it, how to recognize its symptoms, and what can be done to manage and prevent it.

Pericallosal moustache atherosclerosis is a type of atherosclerosis that affects the blood vessels near the corpus callosum, a structure in the brain that connects the left and right hemispheres. Atherosclerosis occurs when fatty substances, cholesterol, cellular waste products, calcium, and other substances build up in the inner lining of an artery. Over time, this buildup, known as plaque, can restrict blood flow or, in severe cases, block the flow entirely, leading to serious health complications such as stroke or heart attack.

Types of Atherosclerosis:

  1. Coronary artery disease (CAD)
  2. Carotid artery disease
  3. Peripheral artery disease (PAD)
  4. Renal artery disease
  5. Mesenteric artery disease

Causes of Pericallosal Moustache Atherosclerosis:

  1. High cholesterol levels in the blood
  2. High blood pressure (hypertension)
  3. Smoking and tobacco use
  4. Diabetes
  5. Obesity or being overweight
  6. Lack of physical activity
  7. Unhealthy diet high in saturated fats and cholesterol
  8. Genetics and family history of heart disease
  9. Aging
  10. Stress and mental health factors
  11. Excessive alcohol consumption
  12. Inflammation in the body
  13. Certain medications that affect cholesterol levels
  14. Sleep apnea
  15. Chronic kidney disease
  16. Autoimmune diseases
  17. Hormonal changes, such as in menopause
  18. Radiation therapy to the head and neck
  19. Exposure to environmental toxins
  20. Poor dental hygiene

Symptoms of Pericallosal Moustache Atherosclerosis:

  1. Chest pain or discomfort (angina)
  2. Shortness of breath
  3. Fatigue
  4. Dizziness or lightheadedness
  5. Nausea
  6. Pain, numbness, weakness, or coldness in the legs or arms, particularly during physical activity or exercise (claudication)
  7. Pain in the neck, jaw, throat, abdomen, or back
  8. Irregular heartbeat (arrhythmia)
  9. Swelling in the ankles, feet, legs, abdomen, or hands
  10. Difficulty speaking or slurred speech
  11. Confusion or difficulty understanding
  12. Vision problems
  13. Weakness or paralysis, usually on one side of the body
  14. Sudden severe headache
  15. Fainting or loss of consciousness
  16. Erectile dysfunction in men
  17. Cold sweats
  18. Pale or bluish skin color
  19. Reduced urine output
  20. Memory problems or cognitive decline

Diagnostic Tests for Pericallosal Moustache Atherosclerosis:

  1. Blood tests to measure cholesterol levels, triglycerides, and other markers of heart health
  2. Electrocardiogram (ECG or EKG) to record the heart’s electrical activity
  3. Stress tests to assess the heart’s function during physical exertion
  4. Echocardiogram to create images of the heart using sound waves
  5. Cardiac catheterization or angiography to visualize the arteries and measure blood pressure within the heart chambers
  6. Computed tomography (CT) scan to produce detailed cross-sectional images of the heart and blood vessels
  7. Magnetic resonance imaging (MRI) to examine the heart and blood vessels using magnetic fields and radio waves
  8. Ankle-brachial index (ABI) test to compare blood pressure in the arms and legs
  9. Doppler ultrasound to evaluate blood flow in the arteries and veins
  10. Coronary calcium scan to detect calcium deposits in the coronary arteries
  11. Carotid ultrasound to check for plaque buildup in the carotid arteries
  12. Lipoprotein(a) test to assess the risk of heart disease
  13. C-reactive protein (CRP) test to measure inflammation in the body
  14. Genetic testing to identify inherited conditions that increase the risk of heart disease
  15. Ambulatory electrocardiography (Holter monitor) to record the heart’s electrical activity over 24 hours
  16. Myocardial perfusion imaging to evaluate blood flow to the heart muscle
  17. Transesophageal echocardiography (TEE) to obtain detailed images of the heart and blood vessels using a probe inserted through the esophagus
  18. Fractional flow reserve (FFR) measurement to assess the severity of narrowing in the coronary arteries
  19. Endothelial function testing to evaluate the health of the blood vessel lining
  20. Positron emission tomography (PET) scan to assess heart function and blood flow

Non-Pharmacological Treatments for Pericallosal Moustache Atherosclerosis:

  1. Lifestyle modifications:
    • Adopting a heart-healthy diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats (such as those found in fish, nuts, and olive oil)
    • Limiting saturated fats, trans fats, cholesterol, sodium, and added sugars
    • Maintaining a healthy weight through regular exercise and physical activity
    • Quitting smoking and avoiding exposure to secondhand smoke
    • Limiting alcohol consumption to moderate levels
    • Managing stress through relaxation techniques, mindfulness, yoga, or counseling
    • Getting an adequate amount of sleep each night
  2. Exercise and physical activity:
    • Engaging in aerobic exercise (such as walking, jogging, swimming, or cycling) for at least 150 minutes per week
    • Incorporating strength training exercises (such as weightlifting or resistance bands) at least two days per week
    • Participating in flexibility and balance exercises (such as yoga or tai chi) to improve overall fitness and reduce the risk of falls
  3. Cardiac rehabilitation:
    • Participating in a structured program of exercise, education, and counseling to improve heart health and reduce the risk of future cardiovascular events
  4. Medical procedures and interventions:
    • Percutaneous coronary intervention (PCI) or angioplasty with stenting to open narrowed or blocked arteries
    • Coronary artery bypass grafting (CABG) surgery to create new routes for blood flow around blocked coronary arteries
    • Carotid endarterectomy to remove plaque from the carotid arteries and restore blood flow to the brain
    • Carotid artery stenting to insert a small mesh tube (stent) to hold the artery open and prevent it from narrowing again
    • Atherectomy to remove plaque from the walls of the arteries using specialized catheters and cutting devices
  5. Devices and implants:
  • Implantable cardioverter-defibrillator (ICD) to monitor heart rhythm and deliver electrical shocks if needed to restore normal heartbeats
  • Pacemaker to regulate the heart rate and rhythm
  • Left ventricular assist device
  1. Surgeries:
    • In severe cases of pericallosal moustache atherosclerosis, surgical interventions may be necessary to restore blood flow to the brain. These may include:
      • Carotid endarterectomy to remove plaque from the carotid arteries.
      • Angioplasty and stenting to widen narrowed arteries and improve blood flow.
      • Bypass surgery to reroute blood flow around blocked or narrowed arteries.


Preventing pericallosal moustache atherosclerosis involves adopting a heart-healthy lifestyle and managing risk factors. Here are some key prevention strategies:

  1. Maintain a healthy weight.
  2. Eat a balanced diet low in saturated and trans fats.
  3. Exercise regularly.
  4. Avoid smoking and limit alcohol consumption.
  5. Monitor and control blood pressure, cholesterol, and blood sugar levels.
  6. Follow medical advice for managing underlying health conditions.

When to See a Doctor:

If you experience symptoms such as headaches, dizziness, weakness, or difficulty speaking, it’s essential to seek medical attention promptly. Additionally, if you have risk factors such as high cholesterol, high blood pressure, or diabetes, regular check-ups with your healthcare provider are crucial for early detection and management of pericallosal moustache atherosclerosis.


Pericallosal moustache atherosclerosis may be a complex condition, but understanding its causes, symptoms, diagnosis, and treatment options can empower individuals to take control of their health. By adopting a heart-healthy lifestyle and working closely with healthcare providers, it’s possible to manage this condition effectively and reduce the risk of complications. If you have any concerns or experience symptoms, don’t hesitate to reach out to your doctor for guidance and support.


Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, geological location, weather and previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.