Erythema Annulare Centrifugum

Erythema Annulare Centrifugum (EAC) is a rare skin condition that causes red, ring-shaped rashes on the skin. In this article, we’ll break down EAC in simple language to help you understand its types, causes, symptoms, diagnosis, treatments, and medications.

Types of Erythema Annulare Centrifugum (EAC):

  1. Classic EAC: The most common form of EAC, characterized by red, ring-shaped rashes that expand outward.
  2. Atypical EAC: This type doesn’t follow the typical ring shape and can appear in various patterns.
  3. Persistent EAC: Rashes in this type last longer than the classic EAC.

Causes of Erythema Annulare Centrifugum:

  1. Unknown: The exact cause of EAC is often unclear, but it may be linked to immune system reactions.
  2. Infections: Some infections, like fungal or viral, can trigger EAC.
  3. Medications: Certain medications, such as antibiotics or diuretics, can lead to EAC.
  4. Insect Bites: In rare cases, insect bites can cause EAC.
  5. Allergies: Allergic reactions to foods, plants, or chemicals may be a factor.
  6. Underlying Health Conditions: Conditions like cancer or autoimmune diseases might be associated with EAC.
  7. Stress: Emotional stress may exacerbate EAC symptoms.
  8. Hormonal Changes: Hormonal fluctuations, such as in pregnancy, could play a role.
  9. Inflammatory Disorders: Conditions like lupus or rheumatoid arthritis can be linked to EAC.
  10. Genetic Predisposition: Some individuals may have a genetic tendency to develop EAC.
  11. Exposure to Harsh Weather: Extreme cold or heat can trigger EAC in susceptible individuals.
  12. Pregnancy: Hormonal changes during pregnancy might lead to EAC.
  13. Vaccinations: Rarely, vaccines can trigger EAC as an immune response.
  14. Gastrointestinal Disorders: Conditions like Crohn’s disease have been associated with EAC.
  15. Sunlight: Overexposure to sunlight can exacerbate EAC symptoms.
  16. Exercise: Strenuous physical activity may worsen EAC in some cases.
  17. Nutritional Deficiencies: Lack of certain vitamins or minerals might contribute to EAC.
  18. Inflammatory Skin Diseases: Conditions like psoriasis can trigger EAC.
  19. Food Sensitivities: Some people may develop EAC in response to specific foods.
  20. Hormone Therapy: Hormone replacement therapy can sometimes be a factor.

Symptoms of Erythema Annulare Centrifugum:

  1. Red, Ring-Shaped Rashes: The hallmark symptom, rashes that form circular or annular shapes.
  2. Itching: The affected areas can be itchy or uncomfortable.
  3. Burning Sensation: Some individuals may experience a burning or stinging feeling.
  4. Enlarging Rings: The rings often grow slowly and expand over time.
  5. Raised Edges: The outer edges of the rings may be slightly raised.
  6. Pale Centers: The centers of the rings can become paler as they grow.
  7. Variable Sizes: The size of the rings can vary from small to several inches in diameter.
  8. Multiple Rings: Sometimes, several rings may appear on the skin at once.
  9. Recurrence: EAC can come and go, with periods of clear skin in between.
  10. Fluctuating Intensity: The redness and itching can vary in intensity.

Diagnostic Tests for Erythema Annulare Centrifugum:

  1. Clinical Examination: A dermatologist can often diagnose EAC by visually inspecting the skin.
  2. Skin Biopsy: A small sample of skin tissue may be taken and examined under a microscope.
  3. Blood Tests: These can help rule out underlying medical conditions.
  4. Patch Testing: To identify potential allergens that trigger EAC.
  5. KOH Prep: A test to check for fungal infections on the skin.
  6. Allergy Testing: Identifying specific allergens through skin or blood tests.
  7. Wood’s Lamp Examination: Used to detect fungal or bacterial infections.
  8. Skin Culture: To determine if a bacterial or fungal infection is present.
  9. Immunological Tests: These can assess the immune system’s involvement.
  10. Phototesting: Evaluating the skin’s reaction to ultraviolet light.
  11. Skin Scraping: To examine for mites or parasites.
  12. Skin Allergen Challenge: Testing individual allergens on the skin.
  13. Patch Testing: Applying potential allergens to the skin and monitoring for reactions.
  14. Skin Prick Test: A quick way to identify allergic sensitivities.
  15. Histopathology: Detailed examination of skin tissue under a microscope.
  16. Skin Swab: To detect bacterial or fungal infections.
  17. Immunofluorescence Studies: To assess immune system involvement.
  18. Tzanck Smear: A test to diagnose viral infections.
  19. Skin Reflectance Spectroscopy: Evaluating skin characteristics.
  20. Skin Allergy Panel: Comprehensive testing for various allergens.

Treatments for Erythema Annulare Centrifugum:

  1. Topical Corticosteroids: Creams or ointments to reduce inflammation and itching.
  2. Antihistamines: Oral medications to relieve itching and discomfort.
  3. Moisturizers: To keep the skin hydrated and reduce dryness.
  4. Calamine Lotion: Soothes itching and irritation.
  5. Emollients: Help maintain skin barrier function.
  6. Avoid Triggers: Identify and avoid triggers that worsen EAC.
  7. UV Therapy: Controlled exposure to ultraviolet light in a medical setting.
  8. Systemic Corticosteroids: Oral steroids in severe cases.
  9. Immune Modulators: Medications that modulate the immune response.
  10. Anti-Fungal Medications: If a fungal infection is present.
  11. Antibiotics: For bacterial infections that may accompany EAC.
  12. Topical Tacrolimus: An immunosuppressant cream.
  13. Phototherapy: Controlled exposure to specific wavelengths of light.
  14. Topical Calcineurin Inhibitors: For those who can’t tolerate steroids.
  15. Cryotherapy: Freezing therapy to reduce inflammation.
  16. Anti-Inflammatory Creams: Non-steroidal options.
  17. Coal Tar Preparations: For chronic EAC.
  18. Topical Anesthetics: To relieve itching and pain.
  19. Oral Antifungal Medications: For severe fungal infections.
  20. Biologic Therapies: Advanced treatments for severe cases.

Medications for Erythema Annulare Centrifugum:

  1. Hydrocortisone: A mild topical steroid.
  2. Prednisone: An oral corticosteroid.
  3. Clobetasol: A potent topical steroid.
  4. Diphenhydramine: An antihistamine for itching.
  5. Loratadine: Non-drowsy antihistamine.
  6. Emollient Creams: Moisturizing creams.
  7. Clotrimazole: Antifungal medication.
  8. Azithromycin: Antibiotic for bacterial infections.
  9. Tacrolimus: An immunosuppressant cream.
  10. Methotrexate: An immune-modulating medication.
  11. Psoralen: Used in combination with phototherapy.
  12. Coal Tar: Helps control inflammation.
  13. Adalimumab: A biologic therapy.
  14. Infliximab: Another biologic option.
  15. Etanercept: A biologic drug.
  16. Certolizumab: Biologic therapy.
  17. Ustekinumab: Biologic for specific cases.
  18. Apremilast: An oral immunosuppressant.
  19. Dapsone: Used in some cases.
  20. Colchicine: An anti-inflammatory medication.

Conclusion:

Erythema Annulare Centrifugum can be a challenging skin condition, but with the right diagnosis and treatment, many people can manage their symptoms effectively. If you suspect you have EAC or are experiencing unusual skin rashes, consult a dermatologist for a proper evaluation and personalized treatment plan. Remember that treatment options may vary depending on the severity and individual factors, so always follow your healthcare provider’s advice for the best outcome.

 

Disclaimer: Each person’s journey is unique, always seek the advice of a medical professional before trying any treatments to ensure to find the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this page or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.

  1. https://medlineplus.gov/skinconditions.html
  2. https://www.aad.org/about/burden-of-skin-disease
  3. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  4. https://www.cdc.gov/niosh/topics/skin/default.html
  5. https://www.skincancer.org/
  6. https://www.jaad.org/
  7. https://www.psoriasis.org/about-psoriasis/
  8. https://books.google.com/books?
  9. https://www.niams.nih.gov/health-topics/skin-diseases
  10. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  11. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  12. https://dermnetnz.org/topics
  13. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  14. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  15. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  16. https://www.nibib.nih.gov/
  17. https://rxharun.com/rxharun/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/
  18. https://www.nei.nih.gov/
  19. https://en.wikipedia.org/wiki/List_of_skin_conditions
  20. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  21. https://en.wikipedia.org/wiki/Skin_condition
  22. https://oxfordtreatment.com/
  23. https://www.nidcd.nih.gov/health/
  24. https://consumer.ftc.gov/articles/w
  25. https://www.nccih.nih.gov/health
  26. https://catalog.ninds.nih.gov/
  27. https://www.aarda.org/diseaselist/
  28. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  29. https://www.nibib.nih.gov/
  30. https://www.nia.nih.gov/health/topics
  31. https://www.nichd.nih.gov/
  32. https://www.nimh.nih.gov/health/topics
  33. https://www.nichd.nih.gov/
  34. https://www.niehs.nih.gov
  35. https://www.nimhd.nih.gov/
  36. https://www.nhlbi.nih.gov/health-topics
  37. https://obssr.od.nih.gov/
  38. https://www.nichd.nih.gov/health/topics
  39. https://rarediseases.info.nih.gov/diseases
  40. https://beta.rarediseases.info.nih.gov/diseases
  41. https://orwh.od.nih.gov/

References
Amazon Best Seller
Bio-Oil Skincare Body Oil, Serum for Scars and Stretchmarks, Face Moisturizer Dry Skin, Non-Greasy, Dermatologist Recommended, Non-Comedogenic, For All Skin Types, with Vitamin A, E, 4.2 oz
Bio-Oil Skincare Body Oil, Serum for Scars and Stretchmarks, Face Moisturizer Dry Skin, Non-Greasy, Dermatologist Recommended, Non-Comedogenic, For All Skin Types, with Vitamin A, E, 4.2 oz
  • HELPS IMPROVES APPEARANCE OF SCARS AND STRETCH MARKS - Dermatologist recommended and clinically proven for scars, stretch marks, uneven skin tone and so much more
  • PACKED WITH NATUAL OILS - Vitamin E helps maintain healthy looking skin while natural Chamomile and Lavender Oil calm and soothe
  • LOCKS IN ESSENTIAL HYDRATION WITHOUT CLOGGING PORES - Bio-Oil Skincare Oil is a uniquely formulated, non-greasy body oil that hydrates skin and helps retain essential moisture
  • PLANET & ANIMAL FRIENDLY — Vegan friendly, paraben free, cruelty free, non-comedogenic, and 100% recyclable
  • FORMULATED FOR ALL SKIN TYPES - Helps soften skin for all types, tones, textures and safe for use on face and body and won't clog pores
$23.49 −$2.00 $21.49 Amazon Prime
Buy Now On Amazon.com Price incl. tax, excl. shipping