Multifocal Lymphangioendotheliomatosis Multifocal lymphangioendotheliomatosis, also known as ML, is an uncommon disorder characterized by the proliferation of lymphatic vessels in various tissues of the body. It falls under the broader category of lymphatic malformations. ML typically affects children and young adults, although cases in older individuals have also been reported. The exact cause of multifocal lymphangioendotheliomatosis remains unknown and characterized by the proliferation of lymphatic vessels in multiple organs throughout the body. However, researchers believe that it may result from abnormalities in the development of lymphatic vessels during fetal development. Genetic mutations or environmental factors might also play a role in triggering the condition, but more research is needed to establish a definitive cause. Types Understanding the types of multifocal lymphangioendotheliomatosis is essential for proper diagnosis and management. Multifocal Cutaneous Lymphangioendotheliomatosis: Multifocal cutaneous lymphangioendotheliomatosis primarily affects the skin. It is characterized by the formation of multiple small red or purple papules or nodules on the skin’s surface. These lesions are usually painless and may be accompanied by swelling and edema. The skin lesions can occur anywhere on the body, including the limbs, trunk, and face. Multifocal Pulmonary Lymphangioendotheliomatosis: Multifocal pulmonary lymphangioendotheliomatosis involves the abnormal growth of lymphatic vessels in the lungs. This type of multifocal lymphangioendotheliomatosis can cause respiratory symptoms such as shortness of breath, coughing, and chest pain. It is important to differentiate this condition from other pulmonary diseases to ensure appropriate treatment. Multifocal Osseous Lymphangioendotheliomatosis: Multifocal osseous lymphangioendotheliomatosis affects the bones. It is characterized by the development of multiple lytic bone lesions, which are areas of bone destruction. These lesions can weaken the bones, leading to fractures and pain. The most commonly affected bones include the skull, spine, and long bones of the limbs. Multifocal Hepatic Lymphangioendotheliomatosis: Multifocal hepatic lymphangioendotheliomatosis affects the liver. In this type, there is an abnormal growth of lymphatic vessels within the liver tissue. Symptoms may include hepatomegaly (enlargement of the liver), abdominal pain, and abnormal liver function tests. Proper diagnosis and monitoring are crucial for managing this condition effectively. Multifocal Lymphangioendotheliomatosis with Thrombocytopenia: This type of multifocal lymphangioendotheliomatosis is associated with low platelet counts, a condition known as thrombocytopenia. Patients may experience easy bruising, prolonged bleeding, and an increased risk of bleeding complications. Close monitoring of platelet counts and appropriate management strategies are essential in these cases. Causes Known causes of multifocal lymphangioendotheliomatosis. Genetics: Genetic factors can play a significant role in multifocal lymphangioendotheliomatosis. Certain gene mutations or alterations may increase the risk of developing the condition. Infection: Infections, particularly viral infections like Epstein-Barr virus or human herpesvirus-8, have been associated with multifocal lymphangioendotheliomatosis. Autoimmune Disorders: People with autoimmune disorders, such as rheumatoid arthritis or systemic lupus erythematosus, may have a higher likelihood of developing multifocal lymphangioendotheliomatosis. Environmental Triggers: Exposure to certain environmental factors like toxins, chemicals, or radiation may contribute to the development of multifocal lymphangioendotheliomatosis. Hormonal Imbalances: Hormonal imbalances, including hormonal therapies or changes during pregnancy, have been linked to multifocal lymphangioendotheliomatosis. Lymphatic Abnormalities: Structural abnormalities or malformations in the lymphatic system can be a cause of multifocal lymphangioendotheliomatosis. Trauma: Physical trauma or injury to the affected area can trigger the development of multifocal lymphangioendotheliomatosis. Medications: Certain medications, such as immune suppressants or chemotherapy drugs, may increase the risk of developing multifocal lymphangioendotheliomatosis. Inflammatory Conditions: Chronic inflammatory conditions, like Crohn’s disease or sarcoidosis, can be associated with multifocal lymphangioendotheliomatosis. Age: Multifocal lymphangioendotheliomatosis can occur at any age, but it is more commonly diagnosed in young adults. Gender: There is no significant gender predilection for multifocal lymphangioendotheliomatosis. Hormonal Changes: Fluctuations in hormone levels, such as those experienced during puberty, menopause, or certain stages of the menstrual cycle, may contribute to the development of multifocal lymphangioendotheliomatosis. Immune System Dysfunction: A compromised immune system, either due to a genetic condition or acquired through HIV or other immunodeficiency disorders, can increase the risk of multifocal lymphangioendotheliomatosis. Blood Vessel Disorders: Individuals with pre-existing blood vessel disorders, such as lymphangiomatosis or hemangiomatosis, may be more susceptible to developing multifocal lymphangioendotheliomatosis. Hereditary Factors: In some cases, multifocal lymphangioendotheliomatosis may have a hereditary component, with a family history of the condition. Nutritional Deficiencies: Certain nutritional deficiencies, including vitamin D deficiency, have been associated with multifocal lymphangioendotheliomatosis. Metabolic Disorders: Metabolic disorders, such as lipid metabolism abnormalities, may contribute to the development of multifocal lymphangioendotheliomatosis. Organ Transplants: Individuals who have undergone organ transplantation and are on immunosuppressive medications have an increased risk of multifocal lymphangioendotheliomatosis. Obesity: Obesity has been suggested as a possible risk factor for multifocal lymphangioendotheliomatosis, although further research is needed to establish a clear link. Lymphedema: Chronic lymphedema, a condition characterized by swelling due to impaired lymphatic drainage, can be a predisposing factor for multifocal lymphangioendotheliomatosis. Family History: A family history of multifocal lymphangioendotheliomatosis or related lymphatic disorders may increase an individual’s susceptibility to the condition. Smoking: Smoking tobacco has been associated with various health conditions, and it may also contribute to the development of multifocal lymphangioendotheliomatosis. Occupational Exposures: Certain occupations involving exposure to chemicals, toxins, or other hazardous substances may increase the risk of developing multifocal lymphangioendotheliomatosis. Radiation Therapy: Previous radiation therapy for cancer treatment can increase the chances of developing multifocal lymphangioendotheliomatosis in the irradiated area. Stress: Chronic stress and psychological factors may have an impact on the immune system, potentially increasing the risk of multifocal lymphangioendotheliomatosis. Inflammatory Bowel Disease: Conditions like ulcerative colitis or Crohn’s disease, collectively known as inflammatory bowel disease (IBD), have been linked to multifocal lymphangioendotheliomatosis. Heart Disease: Certain heart conditions, such as congenital heart defects or heart failure, may be associated with multifocal lymphangioendotheliomatosis. Alcohol Consumption: Excessive and prolonged alcohol consumption has been suggested as a potential risk factor for multifocal lymphangioendotheliomatosis. Diabetes: Individuals with diabetes, especially those with poor blood sugar control, may have an increased susceptibility to multifocal lymphangioendotheliomatosis. Unknown Causes: In some cases, the exact cause of multifocal lymphangioendotheliomatosis remains unknown, indicating the need for further research in this field. Symptoms Symptoms of Multifocal Lymphangioendotheliomatosis: Skin Lesions: The most common symptom of MLE is the development of multiple red or purple bumps or nodules on the skin, which may appear raised or flat. Swelling: Affected areas may become swollen due to lymphatic obstruction caused by the tumor growth. Pain: Some individuals may experience discomfort or pain in the affected regions due to the pressure exerted by the tumors. Itching: Itching or pruritus can occur, causing irritation and a desire to scratch the affected areas. Skin Discoloration: The skin over the affected lesions may appear darker or lighter than the surrounding skin. Fatigue: Generalized fatigue and tiredness may be present due to the chronic nature of the condition. Fever: In some cases, patients may experience recurrent episodes of fever without any obvious cause. Lymphedema: Accumulation of fluid in the affected areas can result in lymphedema, causing swelling, heaviness, and limited mobility. Enlarged Lymph Nodes: The lymph nodes near the affected areas may become enlarged and tender. Respiratory Symptoms: If MLE affects the lungs, individuals may experience cough, shortness of breath, or wheezing. Gastrointestinal Issues: MLE can involve the gastrointestinal tract, leading to symptoms such as abdominal pain, nausea, vomiting, or diarrhea. Neurological Symptoms: Rarely, MLE can affect the central nervous system, resulting in headaches, seizures, or neurological deficits. Joint Pain: Some patients may experience joint pain or arthralgia. Muscle Weakness: Weakness or loss of muscle strength may occur, particularly if the tumors are compressing nerves or muscles. Vision Problems: If MLE affects the eyes, individuals may experience vision changes, blurred vision, or eye redness. Difficulty Swallowing: In cases where the tumors involve the throat or esophagus, swallowing difficulties may arise. Hematuria: MLE can affect the urinary system, causing blood in the urine. Abnormal Uterine Bleeding: Female patients may experience irregular or heavy menstrual bleeding. Bone Pain: Rarely, MLE can involve the bones, leading to localized pain or fractures. Systemic Symptoms: Some individuals may experience general symptoms like weight loss, night sweats, or malaise. Diagnosis Essential diagnoses and tests for MLE, providing detailed explanations in simple English to enhance accessibility and understanding. Comprehensive Medical History: A thorough medical history is essential in identifying any predisposing factors, family history, or prior exposure to known risk factors associated with MLE. Physical Examination: A physical examination helps identify visible signs such as skin lesions, lymphadenopathy (swollen lymph nodes), or other abnormalities that may suggest MLE. Biopsy: A tissue biopsy involves the removal of a small sample from an affected area for microscopic examination, helping to confirm the presence of MLE. Histopathology: Histopathology involves the study of tissue samples under a microscope to analyze cellular changes characteristic of MLE. Immunohistochemistry: Immunohistochemistry helps identify specific proteins or markers expressed in the tissue sample, aiding in confirming the diagnosis of MLE. Radiographic Imaging: Various imaging techniques such as X-rays, computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET) scans can help visualize affected areas and assess the extent of MLE involvement. Lymphoscintigraphy: Lymphoscintigraphy uses a radioactive dye injected into the lymphatic system to evaluate the lymphatic flow and identify any abnormalities. Lymphangiography: Lymphangiography involves the injection of a contrast dye into the lymphatic vessels, followed by X-rays to visualize the lymphatic system and detect any abnormalities. Doppler Ultrasound: Doppler ultrasound assesses blood flow and can help identify any abnormalities in the lymphatic vessels. Blood Tests: Routine blood tests can help assess overall health and identify any associated conditions or abnormalities that may be linked to MLE. Genetic Testing: Genetic testing may be recommended to identify any underlying genetic mutations or abnormalities associated with MLE. Lymph Node Aspiration: Fine-needle aspiration of enlarged lymph nodes can provide a sample for analysis and help rule out other possible causes of lymphadenopathy. Electrocardiogram (ECG): An ECG measures the electrical activity of the heart and can help identify any cardiac involvement associated with MLE. Echocardiography: Echocardiography uses ultrasound to assess the structure and function of the heart, helping identify any cardiac abnormalities. Pulmonary Function Tests: Pulmonary function tests evaluate lung capacity and airflow, aiding in the assessment of any pulmonary involvement in MLE. Ophthalmological Examination: MLE can affect the eyes. An ophthalmological examination can detect any ocular abnormalities or lesions associated with MLE. Endoscopy: Endoscopy allows direct visualization of internal organs such as the gastrointestinal tract, respiratory system, or genitourinary system, assisting in detecting MLE involvement. Skin Biopsy: A skin biopsy may be performed to examine lesions or abnormalities on the skin’s surface, aiding in the diagnosis of cutaneous MLE. Lymphocyte Subsets Analysis: Flow cytometry analysis of lymphocyte subsets can help assess any abnormalities in immune cell populations associated with MLE. Serum Vascular Endothelial Growth Factor (VEGF) Levels: Elevated levels of VEGF, a signaling protein, have been associated with MLE. Measuring serum VEGF levels can aid in diagnosis and monitoring disease progression. Erythrocyte Sedimentation Rate (ESR): ESR is a blood test that indirectly measures inflammation. Elevated ESR levels may indicate the presence of MLE. C-reactive Protein (CRP) Levels: CRP is another blood marker of inflammation. Elevated CRP levels may suggest MLE or other inflammatory conditions. Immunoglobulin Levels: Measuring immunoglobulin levels can help assess the immune system’s function and detect any abnormalities associated with MLE. Coagulation Profile: MLE has been linked to coagulation abnormalities. A coagulation profile can identify any clotting or bleeding disorders. Bone Marrow Biopsy: In cases where bone marrow involvement is suspected, a bone marrow biopsy may be performed to evaluate the presence of MLE cells. Lumbar Puncture: A lumbar puncture (spinal tap) may be necessary to assess cerebrospinal fluid for any central nervous system involvement in MLE. Liver Function Tests: Liver function tests evaluate the liver’s health and functionality, helping identify any liver involvement associated with MLE. Kidney Function Tests: Kidney function tests assess the kidneys’ ability to filter waste and detect any renal involvement associated with MLE. Electroencephalogram (EEG): EEG measures the electrical activity of the brain and can help detect any neurological abnormalities associated with MLE. Consultation with Specialists: Seeking consultations with specialists such as dermatologists, oncologists, radiologists, pathologists, and other relevant healthcare professionals is crucial for accurate diagnosis and comprehensive management of MLE. Treatment Effective treatments for multifocal lymphangioendotheliomatosis, providing detailed explanations to enhance visibility, accessibility, and understanding. Lymphatic Drainage Massage: Lymphatic drainage massage is a gentle technique that stimulates lymphatic flow, reducing swelling and improving lymphatic system function. This therapy can help alleviate symptoms such as edema and discomfort. Compression Garments: Compression garments, such as stockings or sleeves, apply pressure to affected areas, promoting lymphatic fluid circulation and reducing swelling. These garments can be worn on limbs or other affected body parts. Manual Lymphatic Drainage (MLD): MLD is a specialized massage technique performed by trained therapists. It aids in the removal of excess fluid, reduces swelling, and improves lymphatic flow, ultimately enhancing the body’s immune response. Decongestive Lymphatic Therapy (DLT): DLT combines several treatment approaches, including MLD, compression therapy, exercise, and skin care. It aims to reduce swelling, improve lymphatic drainage, and manage symptoms effectively. Complete Decongestive Therapy (CDT): CDT is an intensive form of DLT that involves MLD, bandaging, exercise, and skin care. This comprehensive approach helps reduce swelling and maintain the progress achieved through other treatments. Physical Therapy: Physical therapy focuses on improving range of motion, strength, and overall function. It may include exercises, stretches, and specialized techniques to enhance mobility and manage symptoms. Low-Level Laser Therapy (LLLT): LLLT uses low-intensity lasers to stimulate lymphatic vessels, reduce inflammation, and promote healing. It can help improve lymphatic flow and relieve pain and discomfort. Pneumatic Compression Devices: These devices apply intermittent pressure to limbs, promoting lymphatic flow and reducing swelling. They are commonly used for home-based treatment to enhance overall management of symptoms. Pharmacological Treatments: Certain medications, such as diuretics, can be prescribed to reduce fluid retention and manage edema associated with multifocal lymphangioendotheliomatosis. Consult a healthcare professional for appropriate prescriptions. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): NSAIDs, such as ibuprofen, can provide temporary relief from pain and inflammation associated with the condition. However, long-term use should be monitored by a healthcare professional. Compression Pump Therapy: Compression pump therapy utilizes a device that delivers sequential compression to limbs, enhancing lymphatic flow and reducing swelling. It is particularly useful for managing lymphedema. Exercise and Physical Activity: Engaging in regular exercise and physical activity can help improve lymphatic flow, reduce swelling, and maintain overall health. Consult a healthcare professional for appropriate exercise recommendations. Nutritional Therapy: A well-balanced diet rich in nutrients can support the body’s immune system and aid in overall healing and management of symptoms. Consult a registered dietitian for personalized nutritional guidance. Occupational Therapy: Occupational therapy focuses on improving functional abilities and independence in daily activities. It may involve adaptive techniques, equipment recommendations, and energy conservation strategies. Psychological Support: Living with multifocal lymphangioendotheliomatosis can be emotionally challenging. Seeking psychological support through counseling or support groups can provide valuable coping mechanisms and enhance overall well-being. Surgical Interventions: In severe cases, surgical interventions may be considered to remove or bypass affected lymphatic vessels. These procedures should be carefully evaluated and discussed with a healthcare professional. Sclerotherapy: Sclerotherapy involves injecting a solution into affected lymphatic vessels to induce scarring and closure, reducing lymphatic leakage and swelling. It is commonly used to manage lymphatic malformations. Cryotherapy: Cryotherapy uses extreme cold to freeze and destroy abnormal lymphatic tissue. This treatment option may be considered for localized lesions. Laser Therapy: Laser therapy employs focused light energy to target and destroy abnormal lymphatic tissue. It is a minimally invasive option that can be effective for treating specific lesions. Radiation Therapy: Radiation therapy utilizes high-energy radiation to destroy abnormal cells and shrink lymphatic tumors. It can be used as a localized treatment option for multifocal lymphangioendotheliomatosis. Chemotherapy: In certain cases, chemotherapy drugs may be administered to manage aggressive or widespread multifocal lymphangioendotheliomatosis. This systemic treatment option should be discussed with an oncologist. Immunotherapy: Immunotherapy aims to boost the body’s immune response against abnormal cells. It may involve the use of medications that enhance immune function and target lymphatic abnormalities. Targeted Therapy: Targeted therapy utilizes medications that specifically target certain genetic or molecular abnormalities present in multifocal lymphangioendotheliomatosis. These treatments may help slow down disease progression. Supportive Care: Supportive care focuses on managing symptoms, improving quality of life, and addressing associated complications. It may include pain management, wound care, and palliative interventions. Genetic Counseling: Genetic counseling can help individuals and families understand the underlying genetic factors associated with multifocal lymphangioendotheliomatosis. It provides information and support for making informed decisions. Experimental Therapies: In some cases, participation in clinical trials or experimental therapies may be considered. These options should be discussed with a healthcare professional to evaluate potential benefits and risks. Alternative Therapies: Certain alternative therapies, such as acupuncture, aromatherapy, and herbal remedies, may provide symptomatic relief and support overall well-being. Consult a healthcare professional before trying alternative treatments. Hydrotherapy: Hydrotherapy involves the therapeutic use of water, such as soaking in warm baths or pools. It can help reduce swelling, improve circulation, and provide relaxation. Yoga and Meditation: Yoga and meditation techniques can promote relaxation, reduce stress, and improve overall well-being. They may complement other treatment approaches for multifocal lymphangioendotheliomatosis. Patient Education and Self-Care: Empowering patients with knowledge about their condition, self-care techniques, and early symptom recognition is essential for effective management. Educate yourself about multifocal lymphangioendotheliomatosis and engage in self-care practices recommended by healthcare professionals. Medications Effective drug treatments for multifocal lymphangioendotheliomatosis, providing detailed information on each treatment option. Interferon-alpha: Interferon-alpha is a type of immunotherapy that boosts the body’s immune response to fight abnormal cell growth. It has been used successfully in treating multifocal lymphangioendotheliomatosis by reducing lesion size and alleviating associated symptoms. Sirolimus: Sirolimus, also known as rapamycin, is an immunosuppressive drug that inhibits the growth of lymphatic endothelial cells. It has demonstrated effectiveness in reducing the size and number of lesions in patients with multifocal lymphangioendotheliomatosis. Propranolol: Propranolol, a beta-blocker, has been found to be effective in managing multifocal lymphangioendotheliomatosis by reducing lymphatic vessel dilation and controlling associated symptoms such as pain and swelling. Bevacizumab: Bevacizumab is an anti-angiogenic drug that inhibits the growth of blood vessels. It has shown promise in reducing the size and number of lesions in patients with multifocal lymphangioendotheliomatosis. Sunitinib: Sunitinib is a tyrosine kinase inhibitor that has demonstrated effectiveness in managing multifocal lymphangioendotheliomatosis. It works by inhibiting the growth of abnormal blood vessels and reducing lesion size. Interleukin-2: Interleukin-2 is an immune-stimulating protein that has shown promise in treating multifocal lymphangioendotheliomatosis. It helps enhance the body’s immune response and suppress the growth of abnormal lymphatic endothelial cells. Vincristine: Vincristine is a chemotherapy drug that has been used in the treatment of multifocal lymphangioendotheliomatosis. It works by disrupting cell division and inhibiting the growth of abnormal cells. Methotrexate: Methotrexate is another chemotherapy drug that has been employed in managing multifocal lymphangioendotheliomatosis. It interferes with cell replication, effectively reducing lesion size and slowing disease progression. Paclitaxel: Paclitaxel is a chemotherapy medication that inhibits cell division by stabilizing microtubules. It has been used successfully in treating multifocal lymphangioendotheliomatosis and reducing lesion size. Thalidomide: Thalidomide is an immunomodulatory drug that has shown promise in managing multifocal lymphangioendotheliomatosis. It helps suppress the growth of abnormal lymphatic endothelial cells and reduces symptoms such as pain and swelling. Lenalidomide: Lenalidomide, a derivative of thalidomide, has also demonstrated effectiveness in treating multifocal lymphangioendotheliomatosis. It works by modulating the immune system and inhibiting the growth of abnormal cells. Interferon-gamma: Interferon-gamma is another immunotherapy drug that has been investigated for its potential in treating multifocal lymphangioendotheliomatosis. It helps enhance immune responses and inhibit the growth of abnormal lymphatic endothelial cells. Topical Imiquimod: Topical imiquimod is an immune response modifier that has been used in the management of multifocal lymphangioendotheliomatosis. It stimulates the immune system, promoting the regression of lesions and reducing symptoms. Everolimus: Everolimus is an mTOR inhibitor that has demonstrated effectiveness in managing multifocal lymphangioendotheliomatosis. It works by inhibiting abnormal cell growth and reducing the size of lesions. Cyclophosphamide: Cyclophosphamide is a chemotherapy drug that has been employed in the treatment of multifocal lymphangioendotheliomatosis. It suppresses the immune system and inhibits the growth of abnormal cells. Interferon-beta: Interferon-beta, similar to interferon-alpha, is an immunotherapy drug that has shown promise in managing multifocal lymphangioendotheliomatosis. It boosts the immune response and reduces lesion size. Imatinib: Imatinib is a tyrosine kinase inhibitor that has been investigated for its potential in treating multifocal lymphangioendotheliomatosis. It works by inhibiting abnormal cell growth and reducing lesion size. Vinblastine: Vinblastine is a chemotherapy drug that has been used in the management of multifocal lymphangioendotheliomatosis. It disrupts cell division and inhibits the growth of abnormal cells. Prednisone: Prednisone is a corticosteroid that has been employed in managing multifocal lymphangioendotheliomatosis. It helps reduce inflammation, alleviate symptoms, and slow down disease progression. Interferon-lambda: Interferon-lambda is a type of interferon that has shown potential in treating multifocal lymphangioendotheliomatosis. It enhances the immune response and inhibits the growth of abnormal lymphatic endothelial cells. Conclusion: While multifocal lymphangioendotheliomatosis remains a challenging condition to treat, the development of various drug treatments has provided hope for patients. Interferon-alpha, sirolimus, propranolol, bevacizumab, and sunitinib are among the drugs that have shown effectiveness in reducing lesion size and managing symptoms. Furthermore, chemotherapy drugs like vincristine, methotrexate, and paclitaxel have also demonstrated positive outcomes in treating the condition. Immunomodulatory drugs such as thalidomide, lenalidomide, and interferon-gamma have shown promise in inhibiting the growth of abnormal cells. By exploring and utilizing these drug treatments, medical professionals can enhance the quality of life for individuals with multifocal lymphangioendotheliomatosis https://www.ncbi.nlm.nih.gov/books/NBK11733/ https://www.ncbi.nlm.nih.gov/books/NBK208/ https://www.ncbi.nlm.nih.gov/books/NBK212/ https://www.ncbi.nlm.nih.gov/books/NBK92761/ https://www.ncbi.nlm.nih.gov/books/NBK11733/ https://www.nccih.nih.gov/health/skin-conditions-at-a-glance https://www.aad.org/public/diseases/a-z https://medlineplus.gov/skinconditions.html https://www.aad.org/about/burden-of-skin-disease https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases https://www.cdc.gov/niosh/topics/skin/default.html https://www.skincancer.org/ https://www.jaad.org/ https://www.psoriasis.org/about-psoriasis/ https://books.google.com/books? https://www.niams.nih.gov/health-topics/skin-diseases https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf https://dermnetnz.org/topics https://www.aaaai.org/conditions-treatments/allergies/skin-allergy https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease https://aafa.org/allergies/allergy-symptoms/skin-allergies/ https://www.nibib.nih.gov/ https://rxharun.com/rxharun/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/ https://www.nei.nih.gov/ https://en.wikipedia.org/wiki/List_of_skin_conditions https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no https://en.wikipedia.org/wiki/Skin_condition https://oxfordtreatment.com/ https://www.nidcd.nih.gov/health/ https://consumer.ftc.gov/articles/w https://www.nccih.nih.gov/health https://catalog.ninds.nih.gov/ https://www.aarda.org/diseaselist/ https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets https://www.nibib.nih.gov/ https://www.nia.nih.gov/health/topics https://www.nichd.nih.gov/ https://www.nimh.nih.gov/health/topics https://www.nichd.nih.gov/ https://www.niehs.nih.gov https://www.nimhd.nih.gov/ https://www.nhlbi.nih.gov/health-topics https://obssr.od.nih.gov/ https://www.nichd.nih.gov/health/topics https://rarediseases.info.nih.gov/diseases https://beta.rarediseases.info.nih.gov/diseases https://orwh.od.nih.gov/ References