Dactinomycin – Uses, Dosage, Side Effects, Interaction Dactinomycin is an intravenously administered, antineoplastic antibiotic that is used in the treatment of solid tumors in children and choriocarcinoma in adult women. In high doses, dactinomycin can cause severe liver injury including sinusoidal obstruction syndrome. Dactinomycin is a chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine–cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04) Dactinomycin is an Actinomycin. The mechanism of action of dactinomycin is as a Nucleic Acid Synthesis Inhibitor, and Protein Synthesis Inhibitor. A compound composed of two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) Daptomycin is a cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus. Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant Staphylococcus aureus (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE). Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal tryptophan covalently bonded to decanoic acid. Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil samples from Mount Ararat in Turkey.[rx] Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed daptomycin; it was found that a once-daily dosing scheme reduced side effects while retaining efficacy.[rx] Daptomycin was approved by the FDA on September 12, 2003, and is marketed under the name CUBICIN® by Cubist Pharmaceuticals LLC (Merck & Co.).[rx] Mechanism of Action Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis. The capacity of actinomycins to bind with double-helical DNA is responsible for their biological activity and cytotoxicity. X-ray studies of a crystalline complex between dactinomycin and deoxyguanosine permitted formulation of a model that appears to explain the binding of the drug to DNA. The planar phenoxazone ring intercalates between adjacent guanine–cytosine base pairs of DNA, while the polypeptide chains extend along the minor groove of the helix. The summation of these interactions provides great stability to the dactinomycin-DNA complex, and as a result of the binding of dactinomycin, the transcription of DNA by RNA polymerase is blocked. The DNA-dependent RNA polymerases are much more sensitive to the effects of dactinomycin than are the DNA polymerases. In addition, dactinomycin causes single-strand breaks in DNA, possibly through a free-radical intermediate or as a result of the action of topoisomerase II or Dactinomycin is an antineoplastic antibiotic. The drug has bacteriostatic activity, particularly against gram-positive organisms, but its cytotoxicity precludes its use as an anti-infective agent. Although the exact mechanism(s) of action has not been fully elucidated, the drug appears to inhibit DNA-dependent RNA synthesis by forming a complex with DNA by intercalating with guanine residues and impairing the template activity of DNA. Protein and DNA synthesis are also inhibited but less extensively and at higher concentrations of dactinomycin than are needed to inhibit RNA synthesis. Dactinomycin is immunosuppressive and also possesses some hypocalcemic activity similar to plicamycin. Generally, the actinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi. However, the toxic properties of the actinomycins (including dactinomycin) in relation to antibacterial activity are such as to preclude their use as antibiotics in the treatment of infectious diseases. Because the actinomycins are cytotoxic, they have an antineoplastic effect which has been demonstrated in experimental animals with various types of tumor implant. This cytotoxic action is the basis for their use in the treatment of certain types of cancer. Dactinomycin is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis. Indications Antineoplastic; Anti-Bacterial Agents; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors For the treatment of Wilms’ tumor, childhood rhabdomyosarcoma, Ewing’s sarcoma, and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen. Daptomycin is indicated for the treatment of complicated skin and skin structure infections (cSSSI) in patients one year of age and older. It is also indicated for the treatment of Staphylococcus aureus bloodstream infections (bacteremia) in patients one year of age and older, including in adult patients with right-sided infective endocarditis.[rx] Dactinomycin is an intravenously administered, antineoplastic antibiotic that is used in the treatment of solid tumors in children and choriocarcinoma in adult women. Dactinomycin, as part of a combination chemotherapy and/or multi-modality treatment regimen, is indicated for the treatment of Wilms’ tumor, childhood rhabdomyosarcoma, Ewing’s sarcoma and metastatic, nonseminomatous testicular cancer. Dactinomycin is indicated as a single agent, or as part of a combination chemotherapy regimen, for the treatment of gestational trophoblastic neoplasia. Dactinomycin, as a component of regional perfusion, is indicated for the palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies. Complicated Skin and Skin Structure Infection Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia) Use in Cancer Dactinomycin is approved to be used alone or with other drugs to treat: Ewing sarcoma in adults and children. Gestational trophoblastic disease in adults and children. Rhabdomyosarcoma in adults and children. Solid tumors that are locally recurrent. It is used as palliative and/or adjuvant therapy in adults. Testicular cancer. It is used in adults and children whose nonseminomas have metastasized (spread to other parts of the body). Wilms tumor in adults and children. Dactinomycin is also being studied in the treatment of other types of cancer. Contraindications Serious rash. New primary malignancy. Anemia, bone marrow suppression, geriatric, neutropenia, thrombocytopenia. Herpes infection, infection. Extravasation. Children, hepatotoxicity, infants, sinusoidal obstruction syndrome (SOS), veno-occlusive disease (VOD) Radiation therapy. shingles a bad infection low blood counts due to bone marrow failure anemia decreased blood platelets low levels of white blood cells low levels of a type of white blood cell called neutrophils a blood clot in a vein of the liver liver problems ascites abnormal liver function tests pregnancy a patient who is producing milk and breastfeeding infection caused by the varicella zoster virus exposure to the chickenpox Dosage Strengths: 0.5 mg Wilms’ Tumor As part of a multi-agent combination chemotherapy regimen: 45 mcg/kg IV over 10 to 15 minutes once every 3 to 6 weeks for up to 26 weeks For the treatment of Wilms tumor as part of a multi-phase combination chemotherapy regimen Rhabdomyosarcoma As part of a multi-agent combination chemotherapy regimen: 15 mcg/kg IV over 10 to 15 minutes once daily for 5 days every 3 to 9 weeks for up to 112 weeks For the treatment of rhabdomyosarcoma as part of a multi-phase combination chemotherapy regimen Ewing’s Sarcoma As part of a multi-agent combination chemotherapy regimen: 1250 mcg/m2 IV over 10 to 15 minutes once every 3 weeks for 51 weeks For the treatment of Ewing sarcoma as part of a multi-phase combination chemotherapy regimen Testicular Cancer As part of a cisplatin-based multi-agent combination chemotherapy regimen: 1000 mcg/m2 IV over 10 to 15 minutes once every 3 weeks for 12 weeks For the treatment of metastatic nonseminomatous testicular cancer as part of a multi-phase combination chemotherapy regimen Trophoblastic Disease As a single agent for nonmetastatic and low-risk metastatic disease: 12 mcg/kg IV over 10 to 15 minutes daily for 5 days As part of a multi-agent combination chemotherapy regimen for high-risk metastatic disease: 500 mcg IV over 10 to 15 minutes Days 1 and 2 every 2 weeks for up to 8 weeks For the treatment of post-menarchal patients with gestational trophoblastic neoplasia as a single agent or as part of a combination chemotherapy regimen Solid Tumors In combination with melphalan for lower extremity or pelvis: 50 mcg/kg IV over 10 to 15 minutes once In combination with melphalan for upper extremity: 35 mcg/kg IV once For the treatment of adult patients with locally recurrent or locoregional solid malignancies as a component of palliative or adjunctive regional perfusion Usual Pediatric Dose Wilms’ Tumor As part of a multi-agent combination chemotherapy regimen: 45 mcg/kg IV over 10 to 15 minutes once every 3 to 6 weeks for up to 26 weeks For the treatment of Wilms tumor as part of a multi-phase combination chemotherapy regimen Rhabdomyosarcoma As part of a multi-agent combination chemotherapy regimen: 15 mcg/kg IV over 10 to 15 minutes once daily for 5 days every 3 to 9 weeks for up to 112 weeks For the treatment of rhabdomyosarcoma as part of a multi-phase combination chemotherapy regimen Ewing’s Sarcoma As part of a multi-agent combination chemotherapy regimen: 1250 mcg/m2 IV over 10 to 15 minutes once every 3 weeks for 51 weeks For the treatment of Ewing sarcoma as part of a multi-phase combination chemotherapy regimen Testicular Cancer As part of a cisplatin-based multi-agent combination chemotherapy regimen: 1000 mcg/m2 IV over 10 to 15 minutes once every 3 weeks for 12 weeks For the treatment of metastatic nonseminomatous testicular cancer as part of a multi-phase combination chemotherapy regimen Trophoblastic Disease As a single agent for nonmetastatic and low-risk metastatic disease: 12 mcg/kg IV over 10 to 15 minutes daily for 5 days As part of a multi-agent combination chemotherapy regimen for high-risk metastatic disease: 500 mcg IV over 10 to 15 minutes Days 1 and 2 every 2 weeks for up to 8 weeks For the treatment of post-menarchal pediatric patients with gestational trophoblastic neoplasia as a single agent or as part of a combination chemotherapy regimen Dose Adjustments Calculate the dose for obese or edematous patients based on ideal body weight. Administration advice: Administer the diluted reconstituted product IV over 10 to 15 minutes. Do not use in-line filters with a cellulose ester membrane. Side Effects The Most Common Common adverse drug reaction includes bone marrow suppression, fatigue, hair loss, mouth ulcer, loss of appetite and diarrhea. Actinomycin is a vesicant, if extravasation occurs. vomiting stomach pain diarrhea hair loss hives rash difficulty breathing or swallowing nausea extreme tiredness unusual bleeding or bruising sores in the mouth and throat lack of energy loss of appetite pain in the upper right part of the stomach yellowing of the skin or eyes fever, sore throat, ongoing cough and congestion, or other signs of infection unusual bleeding or bruising black and tarry stools red blood in stools More common Black, tarry stools blood in the urine or stools chills cough diarrhea (continuing) difficulty with swallowing fever heartburn hoarseness lower back or side pain painful or difficult urination pinpoint red spots on the skin sores in the mouth and on the lips stomach pain (continuing) unusual bleeding or bruising unusual tiredness or weakness swelling or tenderness in your stomach (upper right side), rapid weight gain; swelling in your arms or legs; dark urine, jaundice (yellowing of the skin or eyes); redness of your skin or the inside of your mouth and throat (if you are also receiving radiation treatment); sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste; blisters, ulcers, or other skin changes where an injection was given; or low blood cell counts–fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. Rare Blistering, peeling, or loosening of the skin body aches or pain chapped, red, or swollen lips confusion congestion cough difficulty with breathing difficulty with moving difficulty with swallowing dryness or soreness of the throat flushing or redness of the skin irregular heartbeat joint pain or swelling muscle ache, pains, or stiffness muscle cramps in the hands, arms, feet, legs, or face numbness and tingling around the mouth, fingertips, or feet pain at the injection site runny nose scaling, redness, burning, pain, or other signs of inflammation of the lips seizures slow growth stomach cramps swelling of the feet or lower legs tender, swollen glands in the neck tremor unusually warm skin voice changes yellow eyes or skin Drug Interaction DRUG INTERACTION Abacavir Daptomycin may decrease the excretion rate of Abacavir which could result in a higher serum level. Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Daptomycin. Abrocitinib The serum concentration of Daptomycin can be increased when it is combined with Abrocitinib. Aceclofenac Aceclofenac may decrease the excretion rate of Daptomycin which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Acenocoumarol The risk or severity of bleeding can be increased when Daptomycin is combined with Acenocoumarol. Acetaminophen Daptomycin may decrease the excretion rate of Acetaminophen which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Acipimox The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Acipimox. Aclidinium Daptomycin may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Daptomycin may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Daptomycin which could result in a higher serum level. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Daptomycin which could result in a higher serum level. Afatinib The serum concentration of Daptomycin can be increased when it is combined with Afatinib. Albutrepenonacog Daptomycin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. Alclofenac Alclofenac may decrease the excretion rate of Daptomycin which could result in a higher serum level. Aldesleukin Aldesleukin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Alendronic acid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Alendronic acid. Allopurinol Daptomycin may decrease the excretion rate of Allopurinol which could result in a higher serum level. Almasilate Daptomycin may decrease the excretion rate of Almasilate which could result in a higher serum level. Almotriptan Daptomycin may decrease the excretion rate of Almotriptan which could result in a higher serum level. Alogliptin Daptomycin may decrease the excretion rate of Alogliptin which could result in a higher serum level. Alprazolam Daptomycin may decrease the excretion rate of Alprazolam which could result in a higher serum level. Amantadine Daptomycin may decrease the excretion rate of Amantadine which could result in a higher serum level. Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Daptomycin. Amikacin Daptomycin may decrease the excretion rate of Amikacin which could result in a higher serum level. Amiloride Amiloride may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Aminophenazone Aminophenazone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Amiodarone The serum concentration of Daptomycin can be increased when it is combined with Amiodarone. Amitriptyline Daptomycin may decrease the excretion rate of Amitriptyline which could result in a higher serum level. Ammonium chloride Daptomycin may decrease the excretion rate of Ammonium chloride which could result in a higher serum level. Amoxicillin Daptomycin may decrease the excretion rate of Amoxicillin which could result in a higher serum level. Amphetamine Daptomycin may decrease the excretion rate of Amphetamine which could result in a higher serum level. Amphotericin B The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Amphotericin B. Ampicillin Daptomycin may decrease the excretion rate of Ampicillin which could result in a higher serum level. Amrinone Daptomycin may decrease the excretion rate of Amrinone which could result in a higher serum level. Ancestim Daptomycin may decrease the excretion rate of Ancestim which could result in a higher serum level. Antihemophilic Daptomycin may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level. Antipyrine Antipyrine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Antithrombin Daptomycin may decrease the excretion rate of Antithrombin III human which could result in a higher serum level. Antrafenine Antrafenine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Apalutamide The serum concentration of Daptomycin can be decreased when it is combined with Apalutamide. Apixaban The serum concentration of Apixaban can be increased when it is combined with Daptomycin. Apremilast Daptomycin may decrease the excretion rate of Apremilast which could result in a higher serum level. Arformoterol Daptomycin may decrease the excretion rate of Arformoterol which could result in a higher serum level. Arsenic trioxide The serum concentration of Daptomycin can be increased when it is combined with Arsenic trioxide. Articaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Articaine. Asciminib The serum concentration of Daptomycin can be increased when it is combined with Asciminib. Asunaprevir The serum concentration of Daptomycin can be increased when it is combined with Asunaprevir. Atazanavir Atazanavir may decrease the excretion rate of Daptomycin which could result in a higher serum level. Atomoxetine Daptomycin may decrease the excretion rate of Atomoxetine which could result in a higher serum level. Atorvastatin The risk or severity of myopathy can be increased when Atorvastatin is combined with Daptomycin. Auranofin Daptomycin may decrease the excretion rate of Auranofin which could result in a higher serum level. Aurothioglucose Daptomycin may decrease the excretion rate of Aurothioglucose which could result in a higher serum level. Avanafil The serum concentration of Avanafil can be increased when it is combined with Daptomycin. Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Daptomycin. Axitinib The serum concentration of Axitinib can be increased when it is combined with Daptomycin. Azacitidine Daptomycin may decrease the excretion rate of Azacitidine which could result in a higher serum level. Azathioprine Daptomycin may decrease the excretion rate of Azathioprine which could result in a higher serum level. Azelaic acid Daptomycin may decrease the excretion rate of Azelaic acid which could result in a higher serum level. Aztreonam Daptomycin may decrease the excretion rate of Aztreonam which could result in a higher serum level. Bacitracin Bacitracin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Baclofen. Balsalazide Balsalazide may decrease the excretion rate of Daptomycin which could result in a higher serum level. Baricitinib Daptomycin may decrease the excretion rate of Baricitinib which could result in a higher serum level. BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Daptomycin. Belantamab The serum concentration of Belantamab mafodotin can be increased when it is combined with Daptomycin. Belinostat The serum concentration of Belinostat can be increased when it is combined with Daptomycin. Belumosudil The serum concentration of Daptomycin can be increased when it is combined with Belumosudil. Bendamustine The serum concentration of Bendamustine can be increased when it is combined with Daptomycin. Bendroflumet Bendroflumethiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Benorilate Benorilate may decrease the excretion rate of Daptomycin which could result in a higher serum level. Benoxaprofen Benoxaprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Benserazide Daptomycin may decrease the excretion rate of Benserazide which could result in a higher serum level. Benzatropine Daptomycin may decrease the excretion rate of Benzatropine which could result in a higher serum level. Benznidazole Daptomycin may decrease the excretion rate of Benznidazole which could result in a higher serum level. Benzocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Benzocaine. Benzthiazide Benzthiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Benzydamine Benzydamine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Benzyl alcohol. Bepotastine Daptomycin may decrease the excretion rate of Bepotastine which could result in a higher serum level. Berotralstat The serum concentration of Berotralstat can be increased when it is combined with Daptomycin. Betamethasone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Betamethasone. Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Daptomycin. Bezafibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Bezafibrate. Bicisate Daptomycin may decrease the excretion rate of Bicisate which could result in a higher serum level. Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Daptomycin. Bismuth subgallate Daptomycin may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Daptomycin. Bisoxatin Daptomycin may decrease the excretion rate of Bisoxatin which could result in a higher serum level. Bleomycin Daptomycin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Daptomycin. Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Daptomycin. Brentuximab vedotin The serum concentration of Brentuximab vedotin can be increased when it is combined with Daptomycin. Brivaracetam Daptomycin may decrease the excretion rate of Brivaracetam which could result in a higher serum level. Bromazepam Daptomycin may decrease the excretion rate of Bromazepam which could result in a higher serum level. Bromotheophylline Bromotheophylline may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Budesonide Daptomycin may decrease the excretion rate of Budesonide which could result in a higher serum level. Bumadizone Bumadizone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Bumetanide Bumetanide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Bupivacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Bupivacaine. Bupropion Daptomycin may decrease the excretion rate of Bupropion which could result in a higher serum level. Buspirone Daptomycin may decrease the excretion rate of Buspirone which could result in a higher serum level. Butabarbital Daptomycin may decrease the excretion rate of Butabarbital which could result in a higher serum level. Butacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Butacaine. Butamben The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Butamben. Cabazitaxel The serum concentration of Cabazitaxel can be increased when it is combined with Daptomycin. Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Daptomycin. Canagliflozin The serum concentration of Daptomycin can be increased when it is combined with Canagliflozin. Canrenoic acid Canrenoic acid may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Capecitabine Daptomycin may decrease the excretion rate of Capecitabine which could result in a higher serum level. Capmatinib The serum concentration of Daptomycin can be increased when it is combined with Capmatinib. Capreomycin Daptomycin may decrease the excretion rate of Capreomycin which could result in a higher serum level. Capsaicin The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Capsaicin. Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Captopril. Carbamazepine Daptomycin may decrease the excretion rate of Carbamazepine which could result in a higher serum level. Carbidopa Daptomycin may decrease the excretion rate of Carbidopa which could result in a higher serum level. Carbimazole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Carbimazole. Carboplatin Carboplatin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Carfilzomib The serum concentration of Daptomycin can be increased when it is combined with Carfilzomib. Carmustine Daptomycin may decrease the excretion rate of Carmustine which could result in a higher serum level. Carprofen Carprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Carvedilol The serum concentration of Daptomycin can be increased when it is combined with Carvedilol. Cefaclor Cefaclor may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefadroxil Cefadroxil may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefalotin Cefalotin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefamandole Cefamandole may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefapirin Cefapirin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefazolin Cefazolin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefdinir Daptomycin may decrease the excretion rate of Cefdinir which could result in a higher serum level. Cefditoren Cefditoren may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefepime Cefepime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefmenoxime Cefmenoxime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefmetazole Cefmetazole may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefonicid Cefonicid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefoperazone Cefoperazone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceforanide Ceforanide may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefotaxime Cefotaxime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefotetan Cefotetan may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefotiam Cefotiam may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefoxitin Cefoxitin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefpiramide Cefpiramide may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefpirome Cefpirome may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefpodoxime Cefpodoxime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefprozil Cefprozil may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefradine Cefradine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceftazidime Ceftazidime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceftibuten Ceftibuten may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceftizoxime Ceftizoxime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceftobiprole Ceftobiprole may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceftolozane Daptomycin may decrease the excretion rate of Ceftolozane which could result in a higher serum level. Ceftriaxone Ceftriaxone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cefuroxime Cefuroxime may decrease the excretion rate of Daptomycin which could result in a higher serum level. Celecoxib Celecoxib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cephalexin Cephalexin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cephaloglycin Cephaloglycin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Daptomycin. Cerivastatin The risk or severity of myopathy can be increased when Cerivastatin is combined with Daptomycin. Certolizumab pegol Daptomycin may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level. Cetirizine Daptomycin may decrease the excretion rate of Cetirizine which could result in a higher serum level. Cevimeline Daptomycin may decrease the excretion rate of Cevimeline which could result in a higher serum level. Chloral hydrate Daptomycin may decrease the excretion rate of Chloral hydrate which could result in a higher serum level. Chloroprocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Chloroprocaine. Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Chloroquine. Chlorothiazide Chlorothiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Chloroxylenol Daptomycin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. Chlorpromazine Daptomycin may decrease the excretion rate of Chlorpromazine which could result in a higher serum level. Chlorpropamide Daptomycin may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. Chlorthalidone Chlorthalidone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Chlorzoxazone Daptomycin may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level. Choline C 11 Daptomycin may decrease the excretion rate of Choline C 11 which could result in a higher serum level. Choline magnesium Choline magnesium trisalicylate may decrease the excretion rate of Daptomycin which could result in a higher serum level. Choline salicylate Daptomycin may decrease the excretion rate of Choline salicylate which could result in a higher serum level. Chondroitin sulfate Daptomycin may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Chromic chloride Daptomycin may decrease the excretion rate of Chromic chloride which could result in a higher serum level. Chromic nitrate Daptomycin may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. Chromium Daptomycin may decrease the excretion rate of Chromium which could result in a higher serum level. Chromium gluconate Daptomycin may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. Chromium nicotinate Daptomycin may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. Chromous sulfate Daptomycin may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. Cidofovir Cidofovir may decrease the excretion rate of Daptomycin which could result in a higher serum level. Cilostazol Daptomycin may decrease the excretion rate of Cilostazol which could result in a higher serum level. Cimetidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Cimetidine. Cinchocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Cinchocaine. Ciprofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ciprofibrate. Ciprofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ciprofloxacin. Cisatracurium Daptomycin may increase the neuromuscular blocking activities of Cisatracurium. Cisplatin Daptomycin may decrease the excretion rate of Cisplatin which could result in a higher serum level. Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Cladribine. Clarithromycin The serum concentration of Daptomycin can be increased when it is combined with Clarithromycin. Clevidipine Daptomycin may decrease the excretion rate of Clevidipine which could result in a higher serum level. Clobazam The serum concentration of Clobazam can be increased when it is combined with Daptomycin. Clofarabine Daptomycin may decrease the excretion rate of Clofarabine which could result in a higher serum level. Clofazimine The serum concentration of Daptomycin can be increased when it is combined with Clofazimine. Clofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Clofibrate. Clomifene The serum concentration of Clomifene can be increased when it is combined with Daptomycin. Clomipramine Daptomycin may decrease the excretion rate of Clomipramine which could result in a higher serum level. Clonazepam Daptomycin may decrease the excretion rate of Clonazepam which could result in a higher serum level. You Might Also Read Pioglitazone; Uses, Contra indications, Dosage, Side Effects, Drug Interactions Clorazepic acid Daptomycin may decrease the excretion rate of Clorazepic acid which could result in a higher serum level. Clove oil Daptomycin may decrease the excretion rate of Clove oil which could result in a higher serum level. Clozapine Daptomycin may decrease the excretion rate of Clozapine which could result in a higher serum level. Cobicistat The serum concentration of Daptomycin can be increased when it is combined with Cobicistat. Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Daptomycin. Cocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Cocaine. Colchicine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Colchicine. Colistimethate Colistimethate may decrease the excretion rate of Daptomycin which could result in a higher serum level. Colistin Daptomycin may decrease the excretion rate of Colistin which could result in a higher serum level. Conivaptan The serum concentration of Daptomycin can be increased when it is combined with Conivaptan. C. estrogens Daptomycin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level. Copanlisib The serum concentration of Copanlisib can be increased when it is combined with Daptomycin. Corifollitropin alfa Daptomycin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. Crizotinib The serum concentration of Daptomycin can be increased when it is combined with Crizotinib. Curcumin The serum concentration of Daptomycin can be increased when it is combined with Curcumin. Cyanocobalamin Daptomycin may decrease the excretion rate of Cyanocobalamin which could result in a higher serum level. Cyclopenthiazide Cyclopenthiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Cyclosporine The serum concentration of Daptomycin can be increased when it is combined with Cyclosporine. Cyclothiazide Cyclothiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Cytarabine. Dabigatran etexilate The serum concentration of Dabigatran etexilate can be increased when it is combined with Daptomycin. Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Daptomycin. Dacarbazine Daptomycin may decrease the excretion rate of Dacarbazine which could result in a higher serum level. Daclatasvir The serum concentration of Daptomycin can be increased when it is combined with Daclatasvir. Dacomitinib The serum concentration of Daptomycin can be increased when it is combined with Dacomitinib. Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Daptomycin. Dalfampridine Daptomycin may decrease the excretion rate of Dalfampridine which could result in a higher serum level. Dapagliflozin Dapagliflozin may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Daptomycin. Darunavir The serum concentration of Darunavir can be increased when it is combined with Daptomycin. Dasabuvir The serum concentration of Dasabuvir can be increased when it is combined with Daptomycin. Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Daptomycin. Deferiprone Daptomycin may decrease the excretion rate of Deferiprone which could result in a higher serum level. Delafloxacin Daptomycin may decrease the excretion rate of Delafloxacin which could result in a higher serum level. Desipramine Daptomycin may decrease the excretion rate of Desipramine which could result in a higher serum level. Desmopressin Desmopressin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Desvenlafaxine Daptomycin may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level. Deutetrabenazine Daptomycin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. Dexamethasone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Dexamethasone. Dexibuprofen Dexibuprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Dexketoprofen Dexketoprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Dexmedetomidine Daptomycin may decrease the excretion rate of Dexmedetomidine which could result in a higher serum level. Dexpanthenol Daptomycin may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Dexrazoxane Daptomycin may decrease the excretion rate of Dexrazoxane which could result in a higher serum level. Dextran Daptomycin may decrease the excretion rate of Dextran which could result in a higher serum level. Diatrizoate Daptomycin may decrease the excretion rate of Diatrizoate which could result in a higher serum level. Diazepam Daptomycin may decrease the excretion rate of Diazepam which could result in a higher serum level. Dichlorobenzyl Daptomycin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. Diclofenac Diclofenac may decrease the excretion rate of Daptomycin which could result in a higher serum level. Diclofenamide Diclofenamide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Dicoumarol The risk or severity of bleeding can be increased when Daptomycin is combined with Dicoumarol. Dicyclomine Daptomycin may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Didanosine Daptomycin may decrease the excretion rate of Didanosine which could result in a higher serum level. Dienogest Daptomycin may decrease the excretion rate of Dienogest which could result in a higher serum level. Diflunisal Diflunisal may decrease the excretion rate of Daptomycin which could result in a higher serum level. Difluocortolone Daptomycin may decrease the excretion rate of Difluocortolone which could result in a higher serum level. Digitoxin The serum concentration of Digitoxin can be increased when it is combined with Daptomycin. Digoxin Daptomycin may decrease the excretion rate of Digoxin which could result in a higher serum level. Dihydrostrep Dihydrostreptomycin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Dimercaprol Daptomycin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. Dimethyl sulfoxide Daptomycin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. Diosmin The serum concentration of Daptomycin can be increased when it is combined with Diosmin. Diphenhydramine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Diphenhydramine. Disopyramide Daptomycin may decrease the excretion rate of Disopyramide which could result in a higher serum level. Methylephedrine Daptomycin may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level. Dobutamine Daptomycin may decrease the excretion rate of Dobutamine which could result in a higher serum level. Docetaxel The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Docetaxel. Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Daptomycin. Dopamine Daptomycin may decrease the excretion rate of Dopamine which could result in a higher serum level. Doripenem Daptomycin may decrease the excretion rate of Doripenem which could result in a higher serum level. Doxacurium Daptomycin may decrease the excretion rate of Doxacurium which could result in a higher serum level. Doxepin Daptomycin may decrease the excretion rate of Doxepin which could result in a higher serum level. Doxycycline Daptomycin may decrease the excretion rate of Doxycycline which could result in a higher serum level. Dronedarone The serum concentration of Daptomycin can be increased when it is combined with Dronedarone. Drospirenone Drospirenone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Droxidopa Daptomycin may decrease the excretion rate of Droxidopa which could result in a higher serum level. Duloxetine Daptomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level. Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Daptomycin. Dyclonine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Dyclonine. Dyphylline Daptomycin may decrease the excretion rate of Dyphylline which could result in a higher serum level. Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Daptomycin. Edrophonium Daptomycin may decrease the excretion rate of Edrophonium which could result in a higher serum level. Elagolix The serum concentration of Daptomycin can be increased when it is combined with Elagolix. Elbasvir The serum concentration of Elbasvir can be increased when it is combined with Daptomycin. Eliglustat The serum concentration of Daptomycin can be increased when it is combined with Eliglustat. Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Enalapril. Enalaprilat Daptomycin may decrease the excretion rate of Enalaprilat which could result in a higher serum level. Enasidenib The serum concentration of Daptomycin can be increased when it is combined with Enasidenib. Enfortumab vedotin The serum concentration of Enfortumab vedotin can be increased when it is combined with Daptomycin. Entrectinib The serum concentration of Daptomycin can be increased when it is combined with Entrectinib. Enzalutamide Daptomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. Eplerenone Eplerenone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Epoprostenol Daptomycin may decrease the excretion rate of Epoprostenol which could result in a higher serum level. Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Eprosartan. Erdafitinib The serum concentration of Daptomycin can be increased when it is combined with Erdafitinib. Ertapenem Daptomycin may decrease the excretion rate of Ertapenem which could result in a higher serum level. Ertugliflozin Ertugliflozin may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Erythromycin The serum concentration of Daptomycin can be increased when it is combined with Erythromycin. Estazolam Daptomycin may decrease the excretion rate of Estazolam which could result in a higher serum level. Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Daptomycin. Estradiol Daptomycin may decrease the excretion rate of Estradiol which could result in a higher serum level. Estradiol acetate Daptomycin may decrease the excretion rate of Estradiol acetate which could result in a higher serum level. Estradiol cypionate Daptomycin may decrease the excretion rate of Estradiol cypionate which could result in a higher serum level. Estradiol dienanthate Daptomycin may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level. Estradiol valerate Daptomycin may decrease the excretion rate of Estradiol valerate which could result in a higher serum level. Estrone sulfate Daptomycin may decrease the excretion rate of Estrone sulfate which could result in a higher serum level. Eszopiclone Daptomycin may decrease the excretion rate of Eszopiclone which could result in a higher serum level. Etacrynic acid Etacrynic acid may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Etafedrine Daptomycin may decrease the excretion rate of Etafedrine which could result in a higher serum level. Ethambutol Daptomycin may decrease the excretion rate of Ethambutol which could result in a higher serum level. Ethanol The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ethanol. Ethyl chloride The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Ethyl chloride. Etidocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Etidocaine. Etodolac Etodolac may decrease the excretion rate of Daptomycin which could result in a higher serum level. Etomidate Daptomycin may decrease the excretion rate of Etomidate which could result in a higher serum level. Etonogestrel Daptomycin may decrease the excretion rate of Etonogestrel which could result in a higher serum level. Etoposide The serum concentration of Etoposide can be increased when it is combined with Daptomycin. Etoricoxib Etoricoxib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Eucalyptus oil Daptomycin may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. Everolimus The serum concentration of Daptomycin can be increased when it is combined with Everolimus. Ezogabine Daptomycin may decrease the excretion rate of Ezogabine which could result in a higher serum level. Favipiravir The serum concentration of Daptomycin can be increased when it is combined with Favipiravir. Fedratinib The serum concentration of Daptomycin can be increased when it is combined with Fedratinib. Fenbufen Fenbufen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Fenofibrate. Fenofibric acid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Fenofibric acid. Fenoldopam Daptomycin may decrease the excretion rate of Fenoldopam which could result in a higher serum level. Fenoprofen Fenoprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Fentanyl Daptomycin may decrease the excretion rate of Fentanyl which could result in a higher serum level. Fesoterodine Daptomycin may decrease the excretion rate of Fesoterodine which could result in a higher serum level. Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Daptomycin. Finerenone Finerenone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Flavoxate Daptomycin may decrease the excretion rate of Flavoxate which could result in a higher serum level. Flibanserin The serum concentration of Daptomycin can be increased when it is combined with Flibanserin. Floctafenine Floctafenine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Florbetaben Daptomycin may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level. Florbetapir Daptomycin may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level. Floxuridine Daptomycin may decrease the excretion rate of Floxuridine which could result in a higher serum level. Fluconazole The serum concentration of Daptomycin can be increased when it is combined with Fluconazole. Flucytosine Daptomycin may decrease the excretion rate of Flucytosine which could result in a higher serum level. Fludeoxyglucose Daptomycin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level. Fluindione The risk or severity of bleeding can be increased when Daptomycin is combined with Fluindione. Flumazenil Daptomycin may decrease the excretion rate of Flumazenil which could result in a higher serum level. Fluocinolone Daptomycin may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level. Flurazepam Daptomycin may decrease the excretion rate of Flurazepam which could result in a higher serum level. Flurbiprofen Flurbiprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Flutamide Daptomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Fluvastatin The risk or severity of myopathy can be increased when Fluvastatin is combined with Daptomycin. Fluvoxamine Daptomycin may decrease the excretion rate of Fluvoxamine which could result in a higher serum level. Folic acid Daptomycin may decrease the excretion rate of Folic acid which could result in a higher serum level. Fomepizole Daptomycin may decrease the excretion rate of Fomepizole which could result in a higher serum level. Fondaparinux Daptomycin may decrease the excretion rate of Fondaparinux which could result in a higher serum level. Formestane Daptomycin may decrease the excretion rate of Formestane which could result in a higher serum level. Foscarnet Foscarnet may decrease the excretion rate of Daptomycin which could result in a higher serum level. Fosfomycin Daptomycin may decrease the excretion rate of Fosfomycin which could result in a higher serum level. Fosinopril Daptomycin may decrease the excretion rate of Fosinopril which could result in a higher serum level. Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Daptomycin. Framycetin Framycetin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Furosemide Furosemide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Fusidic acid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Fusidic acid. Futibatinib The serum concentration of Futibatinib can be increased when it is combined with Daptomycin. Gabapentin Daptomycin may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level. Gadobenic acid Daptomycin may decrease the excretion rate of Gadobenic acid which could result in a higher serum level. Gadodiamide Daptomycin may decrease the excretion rate of Gadodiamide which could result in a higher serum level. Gadofosveset Daptomycin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level. Gadopentetic acid Daptomycin may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level. Gadoteric acid Daptomycin may decrease the excretion rate of Gadoteric acid which could result in a higher serum level. Gadoteridol Daptomycin may decrease the excretion rate of Gadoteridol which could result in a higher serum level. Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ganciclovir. Gemcitabine The serum concentration of Gemcitabine can be increased when it is combined with Daptomycin. Gemfibrozil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Gemfibrozil. Gentamicin Daptomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level. Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Daptomycin. Gimeracil Daptomycin may decrease the excretion rate of Gimeracil which could result in a higher serum level. Givosiran Givosiran may decrease the excretion rate of Daptomycin which could result in a higher serum level. Glasdegib The serum concentration of Daptomycin can be increased when it is combined with Glasdegib. Glecaprevir The serum concentration of Daptomycin can be increased when it is combined with Glecaprevir. Glipizide Daptomycin may decrease the excretion rate of Glipizide which could result in a higher serum level. Glycerol Daptomycin may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level. Golodirsen Daptomycin may decrease the excretion rate of Golodirsen which could result in a higher serum level. Goserelin Goserelin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Grazoprevir The serum concentration of Grazoprevir can be increased when it is combined with Daptomycin. Guanethidine Daptomycin may decrease the excretion rate of Guanethidine which could result in a higher serum level. Guanfacine Daptomycin may decrease the excretion rate of Guanfacine which could result in a higher serum level. Haloperidol Daptomycin may decrease the excretion rate of Haloperidol which could result in a higher serum level. Hydralazine Daptomycin may decrease the excretion rate of Hydralazine which could result in a higher serum level. Hydrochlorothiazide Hydrochlorothiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Hydroflumethiazide Hydroflumethiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Hydromorphone Daptomycin may decrease the excretion rate of Hydromorphone which could result in a higher serum level. Hydroxocobalamin Daptomycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level. Hydroxyethyl Starch Daptomycin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level. Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ibandronate. Ibuprofen Ibuprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ibutilide Daptomycin may decrease the excretion rate of Ibutilide which could result in a higher serum level. Icatibant Daptomycin may decrease the excretion rate of Icatibant which could result in a higher serum level. Icosapent Icosapent may decrease the excretion rate of Daptomycin which could result in a higher serum level. Idarucizumab Daptomycin may decrease the excretion rate of Idarucizumab which could result in a higher serum level. Idebenone Daptomycin may decrease the excretion rate of Idebenone which could result in a higher serum level. Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Daptomycin. Ifosfamide Daptomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Iloprost. Imipramine The serum concentration of Imipramine can be increased when it is combined with Daptomycin. Indacaterol The serum concentration of Indacaterol can be increased when it is combined with Daptomycin. Indapamide Indapamide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Indigotindisulfonic Daptomycin may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level. Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Indinavir. Indomethacin Indomethacin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Infliximab The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Infliximab is combined with Daptomycin. Inosine pranobex Daptomycin may decrease the excretion rate of Inosine pranobex which could result in a higher serum level. Inositol Daptomycin may decrease the excretion rate of Inositol which could result in a higher serum level. Inotersen Inotersen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Inotuzumab The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Daptomycin. Iobenguane sulfate Daptomycin may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level. Iodixanol Daptomycin may decrease the excretion rate of Iodixanol which could result in a higher serum level. Ioflupane Daptomycin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level. Iopromide Daptomycin may decrease the excretion rate of Iopromide which could result in a higher serum level. Iothalamic acid Daptomycin may decrease the excretion rate of Iothalamic acid which could result in a higher serum level. Ioversol Daptomycin may decrease the excretion rate of Ioversol which could result in a higher serum level. Ioxilan Daptomycin may decrease the excretion rate of Ioxilan which could result in a higher serum level. Ipecac The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ipecac. Ipilimumab Daptomycin may decrease the excretion rate of Ipilimumab which could result in a higher serum level. Isavuconazole The serum concentration of Daptomycin can be increased when it is combined with Isavuconazole. Isavuconazonium The serum concentration of Daptomycin can be increased when it is combined with Isavuconazonium. Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Isoniazid. Isosorbide Isosorbide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Isosorbide Daptomycin may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. Isosulfan blue Daptomycin may decrease the excretion rate of Isosulfan blue which could result in a higher serum level. Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Isotretinoin. Isoxicam Isoxicam may decrease the excretion rate of Daptomycin which could result in a higher serum level. Isradipine Daptomycin may decrease the excretion rate of Isradipine which could result in a higher serum level. Istradefylline The serum concentration of Daptomycin can be increased when it is combined with Istradefylline. Itraconazole The serum concentration of Daptomycin can be increased when it is combined with Itraconazole. Ivacaftor The serum concentration of Daptomycin can be increased when it is combined with Ivacaftor. Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ivermectin. Ixabepilone The serum concentration of Daptomycin can be increased when it is combined with Ixabepilone. Ixazomib Daptomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. Kanamycin Daptomycin may decrease the excretion rate of Kanamycin which could result in a higher serum level. Ketamine Daptomycin may decrease the excretion rate of Ketamine which could result in a higher serum level. Ketazolam Daptomycin may decrease the excretion rate of Ketazolam which could result in a higher serum level. Ketoconazole The serum concentration of Daptomycin can be increased when it is combined with Ketoconazole. Ketoprofen Ketoprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ketorolac Ketorolac may decrease the excretion rate of Daptomycin which could result in a higher serum level. Labetalol Daptomycin may decrease the excretion rate of Labetalol which could result in a higher serum level. Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Lamivudine. Lamotrigine Daptomycin may decrease the excretion rate of Lamotrigine which could result in a higher serum level. Lapatinib The serum concentration of Daptomycin can be increased when it is combined with Lapatinib. Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Daptomycin. Lasmiditan The serum concentration of Daptomycin can be increased when it is combined with Lasmiditan. Latamoxef Latamoxef may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ledipasvir The serum concentration of Daptomycin can be increased when it is combined with Ledipasvir. Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Daptomycin. Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Leflunomide. Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Daptomycin. Lenalidomide Daptomycin may decrease the excretion rate of Lenalidomide which could result in a higher serum level. Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Daptomycin. Lercanidipine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Lercanidipine. Lesinurad Daptomycin may decrease the excretion rate of Lesinurad which could result in a higher serum level. Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Letrozole. Leuprolide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Daptomycin. Levobupivacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Levobupivacaine. Levocarnitine Daptomycin may decrease the excretion rate of Levocarnitine which could result in a higher serum level. Levocetirizine Daptomycin may decrease the excretion rate of Levocetirizine which could result in a higher serum level. Levofloxacin Daptomycin may decrease the excretion rate of Levofloxacin which could result in a higher serum level. Levoketoconazole The serum concentration of Daptomycin can be increased when it is combined with Levoketoconazole. Levomilnacipran Daptomycin may decrease the excretion rate of Levomilnacipran which could result in a higher serum level. Levosalbutamol Daptomycin may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. Lidocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Lidocaine. Linagliptin The serum concentration of Daptomycin can be increased when it is combined with Linagliptin. Liothyronine Daptomycin may decrease the excretion rate of Liothyronine which could result in a higher serum level. Lisinopril Daptomycin may decrease the excretion rate of Lisinopril which could result in a higher serum level. Lithium carbonate Daptomycin may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. Lithium citrate Lithium citrate may decrease the excretion rate of Daptomycin which could result in a higher serum level. Lixisenatide Daptomycin may decrease the excretion rate of Lixisenatide which could result in a higher serum level. Lofexidine Daptomycin may decrease the excretion rate of Lofexidine which could result in a higher serum level. Lomitapide The serum concentration of Daptomycin can be increased when it is combined with Lomitapide. Lonafarnib The serum concentration of Daptomycin can be increased when it is combined with Lonafarnib. Loncastuximab The serum concentration of Loncastuximab tesirine can be increased when it is combined with Daptomycin. Loperamide The serum concentration of Loperamide can be increased when it is combined with Daptomycin. Lopinavir The serum concentration of Daptomycin can be increased when it is combined with Lopinavir. Loracarbef Loracarbef may decrease the excretion rate of Daptomycin which could result in a higher serum level. Lorazepam Daptomycin may decrease the excretion rate of Lorazepam which could result in a higher serum level. Lorcaserin Daptomycin may decrease the excretion rate of Lorcaserin which could result in a higher serum level. Lornoxicam Lornoxicam may decrease the excretion rate of Daptomycin which could result in a higher serum level. Lorpiprazole Daptomycin may decrease the excretion rate of Lorpiprazole which could result in a higher serum level. Lovastatin The risk or severity of myopathy can be increased when Lovastatin is combined with Daptomycin. Loxapine The serum concentration of Daptomycin can be increased when it is combined with Loxapine. Loxoprofen Loxoprofen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Lubiprostone Daptomycin may decrease the excretion rate of Lubiprostone which could result in a higher serum level. Lumacaftor The serum concentration of Daptomycin can be decreased when it is combined with Lumacaftor. Lumiracoxib Lumiracoxib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Daptomycin. Macitentan Daptomycin may decrease the excretion rate of Macitentan which could result in a higher serum level. Magnesium carbonate Daptomycin may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Magnesium chloride Daptomycin may decrease the excretion rate of Magnesium chloride which could result in a higher serum level. Magnesium Daptomycin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. Magnesium trisilicate Daptomycin may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level. Mangafodipir Daptomycin may decrease the excretion rate of Mangafodipir which could result in a higher serum level. Mannitol Mannitol may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Maprotiline Daptomycin may decrease the excretion rate of Maprotiline which could result in a higher serum level. Maribavir The serum concentration of Daptomycin can be increased when it is combined with Maribavir. You Might Also Read Eperisone HCl; Indications, Dosage, Side Effect, Interactions, Pregnancy Mebeverine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Mebeverine. Mecamylamine Daptomycin may decrease the excretion rate of Mecamylamine which could result in a higher serum level. Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Medroxyprogesterone Daptomycin may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level. Mefenamic acid Mefenamic acid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Mefloquine The serum concentration of Daptomycin can be increased when it is combined with Mefloquine. Megestrol acetate Daptomycin may decrease the excretion rate of Megestrol acetate which could result in a higher serum level. Meloxicam The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Meloxicam. Memantine Daptomycin may decrease the excretion rate of Memantine which could result in a higher serum level. Meperidine Daptomycin may decrease the excretion rate of Meperidine which could result in a higher serum level. Mepivacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Mepivacaine. Meropenem Daptomycin may decrease the excretion rate of Meropenem which could result in a higher serum level. Mesalazine Mesalazine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Metamfetamine Daptomycin may decrease the excretion rate of Metamfetamine which could result in a higher serum level. Metamizole Metamizole may decrease the excretion rate of Daptomycin which could result in a higher serum level. Metaxalone Daptomycin may decrease the excretion rate of Metaxalone which could result in a higher serum level. Metformin Daptomycin may decrease the excretion rate of Metformin which could result in a higher serum level. Methadone Daptomycin may decrease the excretion rate of Methadone which could result in a higher serum level. Methazolamide Methazolamide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Methimazole Daptomycin may decrease the excretion rate of Methimazole which could result in a higher serum level. Methotrexate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Methotrexate. Methoxsalen Daptomycin may decrease the excretion rate of Methoxsalen which could result in a higher serum level. Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Methyldopa. Methylene blue The serum concentration of Daptomycin can be increased when it is combined with Methylene blue. Methylnaltrexone Daptomycin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. Methyltestosterone Daptomycin may decrease the excretion rate of Methyltestosterone which could result in a higher serum level. Meticrane Meticrane may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Metoclopramide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Metoclopramide. Metolazone Metolazone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Metoprolol Daptomycin may decrease the excretion rate of Metoprolol which could result in a higher serum level. Metyrapone Daptomycin may decrease the excretion rate of Metyrapone which could result in a higher serum level. Midazolam Daptomycin may decrease the excretion rate of Midazolam which could result in a higher serum level. Mifepristone The serum concentration of Daptomycin can be increased when it is combined with Mifepristone. Migalastat Daptomycin may decrease the excretion rate of Migalastat which could result in a higher serum level. Milnacipran Daptomycin may decrease the excretion rate of Milnacipran which could result in a higher serum level. Milrinone Daptomycin may decrease the excretion rate of Milrinone which could result in a higher serum level. Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Minocycline. Mirabegron The serum concentration of Daptomycin can be increased when it is combined with Mirabegron. Mitapivat The serum concentration of Daptomycin can be increased when it is combined with Mitapivat. Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Montelukast. Morphine The serum concentration of Morphine can be increased when it is combined with Daptomycin. Moxisylyte Daptomycin may decrease the excretion rate of Moxisylyte which could result in a higher serum level. Muzolimine Muzolimine may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Mycophenolate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Mycophenolate mofetil. Mycophenolic acid Daptomycin may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level. N-acetyltyrosine Daptomycin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. Nabumetone Nabumetone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Nadolol Daptomycin may decrease the excretion rate of Nadolol which could result in a higher serum level. Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Nafarelin. Naldemedine Daptomycin may decrease the excretion rate of Naldemedine which could result in a higher serum level. Nalmefene Daptomycin may decrease the excretion rate of Nalmefene which could result in a higher serum level. Naloxone Daptomycin may decrease the excretion rate of Naloxone which could result in a higher serum level. Naltrexone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Naltrexone. Naproxen Naproxen may decrease the excretion rate of Daptomycin which could result in a higher serum level. Nateglinide Daptomycin may decrease the excretion rate of Nateglinide which could result in a higher serum level. Nedaplatin Daptomycin may decrease the excretion rate of Nedaplatin which could result in a higher serum level. Nedocromil Daptomycin may decrease the excretion rate of Nedocromil which could result in a higher serum level. Nefazodone Daptomycin may decrease the excretion rate of Nefazodone which could result in a higher serum level. Neomycin Daptomycin may decrease the excretion rate of Neomycin which could result in a higher serum level. Neratinib The serum concentration of Daptomycin can be increased when it is combined with Neratinib. Netilmicin Daptomycin may decrease the excretion rate of Netilmicin which could result in a higher serum level. Netupitant The serum concentration of Daptomycin can be increased when it is combined with Netupitant. Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Niacin. Nicorandil Daptomycin may decrease the excretion rate of Nicorandil which could result in a higher serum level. Nifedipine Daptomycin may decrease the excretion rate of Nifedipine which could result in a higher serum level. Nilotinib The serum concentration of Daptomycin can be increased when it is combined with Nilotinib. Nilutamide Daptomycin may decrease the excretion rate of Nilutamide which could result in a higher serum level. Nimesulide Nimesulide may decrease the excretion rate of Daptomycin which could result in a higher serum level. Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Daptomycin. Nisoldipine Daptomycin may decrease the excretion rate of Nisoldipine which could result in a higher serum level. Nitric Oxide Daptomycin may decrease the excretion rate of Nitric Oxide which could result in a higher serum level. Nitrofurantoin Daptomycin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. Nitroprusside Daptomycin may decrease the excretion rate of Nitroprusside which could result in a higher serum level. Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Nizatidine. Norfloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Norfloxacin. Norgestimate The serum concentration of Daptomycin can be increased when it is combined with Norgestimate. Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Daptomycin. Octinoxate Daptomycin may decrease the excretion rate of Octinoxate which could result in a higher serum level. Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ofloxacin. Olsalazine Olsalazine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Daptomycin. Ombitasvir The serum concentration of Ombitasvir can be increased when it is combined with Daptomycin. Opium Daptomycin may decrease the excretion rate of Opium which could result in a higher serum level. Oseltamivir Daptomycin may decrease the excretion rate of Oseltamivir which could result in a higher serum level. Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Daptomycin. Oxacillin Daptomycin may decrease the excretion rate of Oxacillin which could result in a higher serum level. Oxaprozin Oxaprozin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Oxazepam Daptomycin may decrease the excretion rate of Oxazepam which could result in a higher serum level. Oxetacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Oxetacaine. Oxybenzone Daptomycin may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Oxybuprocaine. Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Oxyquinoline Daptomycin may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. Paclitaxel The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Paclitaxel. Pacritinib The serum concentration of Daptomycin can be increased when it is combined with Pacritinib. Palbociclib The serum concentration of Daptomycin can be increased when it is combined with Palbociclib. Paliperidone The serum concentration of Daptomycin can be increased when it is combined with Paliperidone. Palonosetron Daptomycin may decrease the excretion rate of Palonosetron which could result in a higher serum level. Pamidronic acid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Pamidronic acid. Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Daptomycin. Pantoprazole Daptomycin may decrease the excretion rate of Pantoprazole which could result in a higher serum level. Parecoxib Parecoxib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Paritaprevir The serum concentration of Paritaprevir can be increased when it is combined with Daptomycin. Paromomycin Paromomycin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Patent Blue Daptomycin may decrease the excretion rate of Patent Blue which could result in a higher serum level. Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Daptomycin. Pegaptanib Daptomycin may decrease the excretion rate of Pegaptanib which could result in a higher serum level. Peginesatide Daptomycin may decrease the excretion rate of Peginesatide which could result in a higher serum level. Pemetrexed Daptomycin may decrease the excretion rate of Pemetrexed which could result in a higher serum level. Penbutolol Daptomycin may decrease the excretion rate of Penbutolol which could result in a higher serum level. Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Penicillamine. Pentaerythritol Daptomycin may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level. Pentamidine Pentamidine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Pentastarch Daptomycin may decrease the excretion rate of Pentastarch which could result in a higher serum level. Pentetic acid Daptomycin may decrease the excretion rate of Pentetic acid which could result in a higher serum level. Pentobarbital Daptomycin may decrease the excretion rate of Pentobarbital which could result in a higher serum level. Pentostatin Daptomycin may decrease the excretion rate of Pentostatin which could result in a higher serum level. Pentoxifylline Daptomycin may decrease the excretion rate of Pentoxifylline which could result in a higher serum level. Perindopril Daptomycin may decrease the excretion rate of Perindopril which could result in a higher serum level. Permethrin Daptomycin may decrease the excretion rate of Permethrin which could result in a higher serum level. Phenazopyridine Phenazopyridine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Phenelzine Daptomycin may decrease the excretion rate of Phenelzine which could result in a higher serum level. Phenindione The risk or severity of bleeding can be increased when Daptomycin is combined with Phenindione. Phenol The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Phenol. Phenprocoumon The risk or severity of bleeding can be increased when Daptomycin is combined with Phenprocoumon. Phentolamine Daptomycin may decrease the excretion rate of Phentolamine which could result in a higher serum level. Phenylbutazone Phenylbutazone may decrease the excretion rate of Daptomycin which could result in a higher serum level. Phenytoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Phenytoin. Pholcodine Daptomycin may decrease the excretion rate of Pholcodine which could result in a higher serum level. Phosphoric acid Daptomycin may decrease the excretion rate of Phosphoric acid which could result in a higher serum level. Phylloquinone Daptomycin may decrease the excretion rate of Phylloquinone which could result in a higher serum level. Pibrentasvir The serum concentration of Daptomycin can be increased when it is combined with Pibrentasvir. Picosulfuric acid Daptomycin may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level. Pindolol Daptomycin may decrease the excretion rate of Pindolol which could result in a higher serum level. Piperacillin Daptomycin may decrease the excretion rate of Piperacillin which could result in a higher serum level. Piracetam Daptomycin may decrease the excretion rate of Piracetam which could result in a higher serum level. Piretanide Piretanide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Piroxicam Piroxicam may decrease the excretion rate of Daptomycin which could result in a higher serum level. Pitavastatin The risk or severity of myopathy can be increased when Pitavastatin is combined with Daptomycin. Pitolisant The serum concentration of Daptomycin can be increased when it is combined with Pitolisant. Plazomicin Daptomycin may decrease the excretion rate of Plazomicin which could result in a higher serum level. Plerixafor Daptomycin may decrease the excretion rate of Plerixafor which could result in a higher serum level. Polythiazide Polythiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Daptomycin. Ponatinib The serum concentration of Daptomycin can be increased when it is combined with Ponatinib. Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Daptomycin. Potassium Potassium may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Potassium acetate Daptomycin may decrease the excretion rate of Potassium acetate which could result in a higher serum level. Potassium bicarbonate Daptomycin may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. Potassium cation Potassium cation may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Potassium chloride Daptomycin may decrease the excretion rate of Potassium chloride which could result in a higher serum level. Potassium citrate Potassium citrate may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Potassium nitrate Daptomycin may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. Potassium perchlorate Daptomycin may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level. Potassium sulfate Daptomycin may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. Pralatrexate Daptomycin may decrease the excretion rate of Pralatrexate which could result in a higher serum level. Pralidoxime Daptomycin may decrease the excretion rate of Pralidoxime which could result in a higher serum level. Pralsetinib The serum concentration of Daptomycin can be increased when it is combined with Pralsetinib. Pramipexole Daptomycin may decrease the excretion rate of Pramipexole which could result in a higher serum level. Pramocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Pramocaine. Prasugrel Daptomycin may decrease the excretion rate of Prasugrel which could result in a higher serum level. Pravastatin The risk or severity of myopathy can be increased when Pravastatin is combined with Daptomycin. Prednisolone phosphate The serum concentration of Prednisolone phosphate can be increased when it is combined with Daptomycin. Prednisone Daptomycin may decrease the excretion rate of Prednisone which could result in a higher serum level. Pregabalin Daptomycin may decrease the excretion rate of Pregabalin which could result in a higher serum level. Prilocaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Prilocaine. Probenecid Daptomycin may decrease the excretion rate of Probenecid which could result in a higher serum level. Procainamide Daptomycin may decrease the excretion rate of Procainamide which could result in a higher serum level. Procaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Procaine. Procaine benzylpenicillin Daptomycin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Procarbazine. Promethazine Daptomycin may decrease the excretion rate of Promethazine which could result in a higher serum level. Propafenone The serum concentration of Daptomycin can be increased when it is combined with Propafenone. Propantheline Daptomycin may decrease the excretion rate of Propantheline which could result in a higher serum level. Proparacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Proparacaine. Propiverine Daptomycin may decrease the excretion rate of Propiverine which could result in a higher serum level. Propofol The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Propofol. Propoxycaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Propoxycaine. Propranolol Daptomycin may decrease the excretion rate of Propranolol which could result in a higher serum level. Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Propylthiouracil. Prucalopride Daptomycin may decrease the excretion rate of Prucalopride which could result in a higher serum level. Pyrantel Daptomycin may decrease the excretion rate of Pyrantel which could result in a higher serum level. Pyrazinamide Daptomycin may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Daptomycin may decrease the excretion rate of Pyridoxine which could result in a higher serum level. Pyrithione Daptomycin may decrease the excretion rate of Pyrithione which could result in a higher serum level. Quetiapine Daptomycin may decrease the excretion rate of Quetiapine which could result in a higher serum level. Quinethazone Quinethazone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Quinidine Daptomycin may decrease the excretion rate of Quinidine which could result in a higher serum level. Quinine The serum concentration of Daptomycin can be increased when it is combined with Quinine. Rabeprazole Daptomycin may decrease the excretion rate of Rabeprazole which could result in a higher serum level. Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Raltegravir. Ramelteon Daptomycin may decrease the excretion rate of Ramelteon which could result in a higher serum level. Ranitidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ranitidine. Ranolazine The serum concentration of Daptomycin can be increased when it is combined with Ranolazine. Rasagiline Daptomycin may decrease the excretion rate of Rasagiline which could result in a higher serum level. Regorafenib The serum concentration of Daptomycin can be increased when it is combined with Regorafenib. Relugolix The serum concentration of Relugolix can be increased when it is combined with Daptomycin. Reserpine The serum concentration of Daptomycin can be increased when it is combined with Reserpine. Resorcinol Daptomycin may decrease the excretion rate of Resorcinol which could result in a higher serum level. Revefenacin The serum concentration of Revefenacin can be increased when it is combined with Daptomycin. You Might Also Read Levetiracetam - Uses, Dosage, Side Effects, Interactions Ribavirin Daptomycin may decrease the excretion rate of Ribavirin which could result in a higher serum level. Ribostamycin Daptomycin may decrease the excretion rate of Ribostamycin which could result in a higher serum level. Rifamycin The serum concentration of Daptomycin can be increased when it is combined with Rifamycin. Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Daptomycin. Riociguat The serum concentration of Riociguat can be increased when it is combined with Daptomycin. Ripretinib The serum concentration of Daptomycin can be increased when it is combined with Ripretinib. Risedronic acid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Risedronic acid. Ritonavir The serum concentration of Daptomycin can be increased when it is combined with Ritonavir. Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Daptomycin. Rizatriptan Daptomycin may decrease the excretion rate of Rizatriptan which could result in a higher serum level. Rofecoxib Rofecoxib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Roflumilast Daptomycin may decrease the excretion rate of Roflumilast which could result in a higher serum level. Rolapitant The serum concentration of Daptomycin can be increased when it is combined with Rolapitant. Romidepsin The serum concentration of Romidepsin can be increased when it is combined with Daptomycin. Ropivacaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Ropivacaine. Rosiglitazone Daptomycin may decrease the excretion rate of Rosiglitazone which could result in a higher serum level. Rosuvastatin The risk or severity of myopathy can be increased when Rosuvastatin is combined with Daptomycin. Ruxolitinib Daptomycin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level. Sacubitril Daptomycin may decrease the excretion rate of Sacubitril which could result in a higher serum level. Salbutamol Daptomycin may decrease the excretion rate of Salbutamol which could result in a higher serum level. Salicylamide Salicylamide may decrease the excretion rate of Daptomycin which could result in a higher serum level. Salicylic acid Salicylic acid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Salmeterol The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Salmeterol. Salmon calcitonin Salmon calcitonin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Salsalate Salsalate may decrease the excretion rate of Daptomycin which could result in a higher serum level. Sapropterin The serum concentration of Daptomycin can be increased when it is combined with Sapropterin. Saquinavir The serum concentration of Daptomycin can be increased when it is combined with Saquinavir. Sarecycline The serum concentration of Daptomycin can be increased when it is combined with Sarecycline. Saxagliptin Daptomycin may decrease the excretion rate of Saxagliptin which could result in a higher serum level. Secobarbital Daptomycin may decrease the excretion rate of Secobarbital which could result in a higher serum level. Selenious acid Daptomycin may decrease the excretion rate of Selenious acid which could result in a higher serum level. Selenium Daptomycin may decrease the excretion rate of Selenium which could result in a higher serum level. Selexipag The serum concentration of Selexipag can be increased when it is combined with Daptomycin. Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Daptomycin. Sibutramine Daptomycin may decrease the excretion rate of Sibutramine which could result in a higher serum level. Sildenafil The serum concentration of Daptomycin can be increased when it is combined with Sildenafil. Silodosin The serum concentration of Silodosin can be increased when it is combined with Daptomycin. Simeprevir The serum concentration of Daptomycin can be increased when it is combined with Simeprevir. Simvastatin The risk or severity of myopathy can be increased when Simvastatin is combined with Daptomycin. Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Daptomycin. Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Daptomycin. Sodium acetate Daptomycin may decrease the excretion rate of Sodium acetate which could result in a higher serum level. Sodium aurothio Daptomycin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium fluoride Daptomycin may decrease the excretion rate of Sodium fluoride which could result in a higher serum level. Sodium sulfate Daptomycin may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Daptomycin. Solriamfetol Daptomycin may decrease the excretion rate of Solriamfetol which could result in a higher serum level. Somatotropin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Somatotropin is combined with Daptomycin. Sorafenib The serum concentration of Daptomycin can be increased when it is combined with Sorafenib. Sorbitol Daptomycin may decrease the excretion rate of Sorbitol which could result in a higher serum level. Sotagliflozin The serum concentration of Daptomycin can be increased when it is combined with Sotagliflozin. Sotorasib The serum concentration of Daptomycin can be increased when it is combined with Sotorasib. Spironolactone Spironolactone may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Stavudine. Stiripentol The excretion of Daptomycin can be decreased when combined with Stiripentol. Streptomycin Daptomycin may decrease the excretion rate of Streptomycin which could result in a higher serum level. Strontium chloride Daptomycin may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Sucralfate Daptomycin may decrease the excretion rate of Sucralfate which could result in a higher serum level. Sulbactam Daptomycin may decrease the excretion rate of Sulbactam which could result in a higher serum level. Sulfadiazine Daptomycin may decrease the excretion rate of Sulfadiazine which could result in a higher serum level. Sulfamethoxazole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Sulfamethoxazole. Sulfasalazine Sulfasalazine may decrease the excretion rate of Daptomycin which could result in a higher serum level. Sulindac Sulindac may decrease the excretion rate of Daptomycin which could result in a higher serum level. Sumatriptan Daptomycin may decrease the excretion rate of Sumatriptan which could result in a higher serum level. Suvorexant The serum concentration of Daptomycin can be increased when it is combined with Suvorexant. S Estrogens, A Daptomycin may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level. S Estrogens, B Daptomycin may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level. Tacrine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Tacrine. Tacrolimus The serum concentration of Daptomycin can be increased when it is combined with Tacrolimus. Tadalafil Daptomycin may decrease the excretion rate of Tadalafil which could result in a higher serum level. Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Daptomycin. Tamoxifen The serum concentration of Daptomycin can be increased when it is combined with Tamoxifen. Tamsulosin Daptomycin may decrease the excretion rate of Tamsulosin which could result in a higher serum level. Tasimelteon Daptomycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level. Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Daptomycin. Technetium Daptomycin may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level. Technetium Daptomycin may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level. Technetium Daptomycin may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level. Technetium Daptomycin may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level. Technetium The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Daptomycin. Teduglutide Daptomycin may decrease the excretion rate of Teduglutide which could result in a higher serum level. Tegafur Daptomycin may decrease the excretion rate of Tegafur which could result in a higher serum level. Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Daptomycin. Telaprevir The serum concentration of Daptomycin can be increased when it is combined with Telaprevir. Telavancin Daptomycin may decrease the excretion rate of Telavancin which could result in a higher serum level. Temazepam Daptomycin may decrease the excretion rate of Temazepam which could result in a higher serum level. Temozolomide Daptomycin may decrease the excretion rate of Temozolomide which could result in a higher serum level. Temsirolimus The serum concentration of Daptomycin can be increased when it is combined with Temsirolimus. Tenofovir alafenamide Tenofovir alafenamide may decrease the excretion rate of Daptomycin which could result in a higher serum level. Tenofovir disoproxil The serum concentration of Tenofovir disoproxil can be increased when it is combined with Daptomycin. Tenoxicam Tenoxicam may decrease the excretion rate of Daptomycin which could result in a higher serum level. Tepotinib The serum concentration of Daptomycin can be increased when it is combined with Tepotinib. Terbinafine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Terbinafine. Terbutaline Daptomycin may decrease the excretion rate of Terbutaline which could result in a higher serum level. Testolactone Daptomycin may decrease the excretion rate of Testolactone which could result in a higher serum level. Testosterone Daptomycin may decrease the excretion rate of Testosterone which could result in a higher serum level. Testosterone cypionate Daptomycin may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level. Testosterone enanthate Daptomycin may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level. Testosterone Daptomycin may decrease the excretion rate of Testosterone propionate which could result in a higher serum level. Testosterone Daptomycin may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level. Tetracaine The risk or severity of methemoglobinemia can be increased when Daptomycin is combined with Tetracaine. Tetracycline Daptomycin may decrease the excretion rate of Tetracycline which could result in a higher serum level. Tetradecyl hydrogen Daptomycin may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. Tezacaftor The serum concentration of Tezacaftor can be increased when it is combined with Daptomycin. Thiabendazole Daptomycin may decrease the excretion rate of Thiabendazole which could result in a higher serum level. Thiethylperazine Daptomycin may decrease the excretion rate of Thiethylperazine which could result in a higher serum level. Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Ticagrelor The serum concentration of Daptomycin can be increased when it is combined with Ticagrelor. Ticlopidine Daptomycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level. Tiludronic acid Daptomycin may decrease the excretion rate of Tiludronic acid which could result in a higher serum level. Timolol Daptomycin may decrease the excretion rate of Timolol which could result in a higher serum level. Tinidazole Daptomycin may decrease the excretion rate of Tinidazole which could result in a higher serum level. Tiopronin Daptomycin may decrease the excretion rate of Tiopronin which could result in a higher serum level. Tiotropium Daptomycin may decrease the excretion rate of Tiotropium which could result in a higher serum level. Tipranavir The serum concentration of Daptomycin can be increased when it is combined with Tipranavir. Tirofiban Daptomycin may decrease the excretion rate of Tirofiban which could result in a higher serum level. Tivozanib The serum concentration of Tivozanib can be increased when it is combined with Daptomycin. Tixocortol Daptomycin may decrease the excretion rate of Tixocortol which could result in a higher serum level. Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Daptomycin. Tocopherol Daptomycin may decrease the excretion rate of Tocopherol which could result in a higher serum level. Tolazamide Daptomycin may decrease the excretion rate of Tolazamide which could result in a higher serum level. Tolbutamide Daptomycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level. Tolcapone Daptomycin may decrease the excretion rate of Tolcapone which could result in a higher serum level. Tolfenamic acid Tolfenamic acid may decrease the excretion rate of Daptomycin which could result in a higher serum level. Tolmetin Tolmetin may decrease the excretion rate of Daptomycin which could result in a higher serum level. Tolterodine Daptomycin may decrease the excretion rate of Tolterodine which could result in a higher serum level. Tolvaptan Tolvaptan may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Topiramate Daptomycin may decrease the excretion rate of Topiramate which could result in a higher serum level. Topotecan The serum concentration of Topotecan can be increased when it is combined with Daptomycin. Torasemide Torasemide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Toremifene The serum concentration of Daptomycin can be increased when it is combined with Toremifene. Tositumomab Daptomycin may decrease the excretion rate of Tositumomab which could result in a higher serum level. Trabectedin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Trabectedin. Tramadol Daptomycin may decrease the excretion rate of Tramadol which could result in a higher serum level. Trametinib Daptomycin may decrease the excretion rate of Trametinib which could result in a higher serum level. Trastuzumab The serum concentration of Trastuzumab emtansine can be increased when it is combined with Daptomycin. Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Triamcinolone. Triamterene Triamterene may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Triazolam. Trichlormethiazide Trichlormethiazide may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy. Triethylenetetramine Daptomycin may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level. Trifluridine Daptomycin may decrease the excretion rate of Trifluridine which could result in a higher serum level. Trilaciclib The serum concentration of Trilaciclib can be increased when it is combined with Daptomycin. Trimebutine Daptomycin may decrease the excretion rate of Trimebutine which could result in a higher serum level. Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Trimethoprim. Trimetrexate Daptomycin may decrease the excretion rate of Trimetrexate which could result in a higher serum level. Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Daptomycin. Tropisetron Daptomycin may decrease the excretion rate of Tropisetron which could result in a higher serum level. Tucatinib Tucatinib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Daptomycin. Ubidecarenone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Ubidecarenone. Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Daptomycin. Umbralisib The serum concentration of Daptomycin can be increased when it is combined with Umbralisib. Umeclidinium The serum concentration of Umeclidinium can be increased when it is combined with Daptomycin. Vaborbactam Daptomycin may decrease the excretion rate of Vaborbactam which could result in a higher serum level. Valaciclovir Valaciclovir may decrease the excretion rate of Daptomycin which could result in a higher serum level. Valbenazine Daptomycin may decrease the excretion rate of Valbenazine which could result in a higher serum level. Valdecoxib Valdecoxib may decrease the excretion rate of Daptomycin which could result in a higher serum level. Valganciclovir Daptomycin may decrease the excretion rate of Valganciclovir which could result in a higher serum level. Vancomycin Daptomycin may decrease the excretion rate of Vancomycin which could result in a higher serum level. Vandetanib The serum concentration of Daptomycin can be increased when it is combined with Vandetanib. Vardenafil The serum concentration of Daptomycin can be increased when it is combined with Vardenafil. Varenicline Daptomycin may decrease the excretion rate of Varenicline which could result in a higher serum level. Velpatasvir The serum concentration of Daptomycin can be increased when it is combined with Velpatasvir. Vemurafenib The serum concentration of Daptomycin can be increased when it is combined with Vemurafenib. Venetoclax The serum concentration of Daptomycin can be increased when it is combined with Venetoclax. Venlafaxine Daptomycin may decrease the excretion rate of Venlafaxine which could result in a higher serum level. Verapamil The serum concentration of Daptomycin can be increased when it is combined with Verapamil. Vibrio cholerae The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Daptomycin. Vilanterol Daptomycin may decrease the excretion rate of Vilanterol which could result in a higher serum level. Viloxazine Daptomycin may decrease the excretion rate of Viloxazine which could result in a higher serum level. Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Daptomycin. Vincristine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Vincristine. Vinflunine The serum concentration of Vinflunine can be increased when it is combined with Daptomycin. Voclosporin The serum concentration of Daptomycin can be increased when it is combined with Voclosporin. Vorapaxar The serum concentration of Daptomycin can be increased when it is combined with Vorapaxar. Vortioxetine Daptomycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level. Voxilaprevir The serum concentration of Daptomycin can be increased when it is combined with Voxilaprevir. Warfarin Daptomycin may decrease the excretion rate of Warfarin which could result in a higher serum level. Zaleplon Daptomycin may decrease the excretion rate of Zaleplon which could result in a higher serum level. Zanamivir Daptomycin may decrease the excretion rate of Zanamivir which could result in a higher serum level. Zidovudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Zidovudine. Zonisamide The serum concentration of Daptomycin can be increased when it is combined with Zonisamide. Pregnancy and Lactation AU TGA pregnancy category: D US FDA pregnancy category: Not assigned. Pregnancy Based on findings from animal studies and its mechanism of action, this drug can cause fetal harm when administered to a pregnant woman. Verify negative pregnancy status in females of reproductive potential prior to initiating therapy. Advise females of reproductive potential to use effective contraception during therapy and for at least 6 months after. Because of the potential for genotoxicity, advise males with female partners of reproductive potential to use effective contraception during therapy and for 3 months after. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus. Lactation No information is available on the use of this drug during breastfeeding. Most experts consider breastfeeding contraindicated during maternal antineoplastic therapy. The effects in the nursing infant are unknown. The manufacturer recommends that breastfeeding be discontinued during therapy and for at least 14 days after. How should this medicine be used? Dactinomycin comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. The length of treatment depends on the type of cancer you have, the types of other drugs you are taking, and how well your body responds to treatment. Your doctor may need to stop or delay your treatment if you experience certain side effects. Dactinomycin may also be injected by a doctor directly into a specific the part of the body or the organ to treat the area where a tumor is located. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient. Dactinomycin is also sometimes used to treat a type of cancer of the ovaries (a cancer that begins in the female reproductive organs where eggs are formed). Talk to your doctor about the risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. What special precautions should I follow? Before receiving dactinomycin, tell your doctor and pharmacist if you are allergic to dactinomycin, any other medications, or any of the ingredients in dactinomycin injection. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. tell your doctor if you have chickenpox or herpes zoster (shingles). Your doctor will probably not want you to receive dactinomycin injection. tell your doctor if you have previously received or are currently receiving radiation therapy. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breast-feed while you are receiving dactinomycin. If you become pregnant while receiving dactinomycin, call your doctor. Dactinomycin may harm the fetus. do not have any vaccinations without talking to your doctor. References https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050682s025lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/050682s033lbl.pdf https://pubchem.ncbi.nlm.nih.gov/compound/Dactinomycin https://pubchem.ncbi.nlm.nih.gov/compound/2019 https://en.wikipedia.org/wiki/Dactinomycin https://go.drugbank.com/drugs/DB00080 https://medlineplus.gov/druginfo/meds/a682224.html https://www.mayoclinic.org/drugs-supplements/dactinomycin-intravenous-route/side-effects/drg-20063277?p=1 https://www.drugs.com/mtm/dactinomycin.html https://www.webmd.com/drugs/2/drug-19921/dactinomycin-intravenous/details/list-contraindications ChEMBL http://www.ebi.ac.uk/Information/termsofuse.html https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1554/ ChEMBL Protein Target Tree https://www.ebi.ac.uk/chembl/g/#browse/targets Comparative Toxicogenomics Database (CTD) http://ctdbase.org/about/legal.jsp Dactinomycin https://ctdbase.org/detail.go?type=chem&acc=D003609 Drug Gene Interaction database (DGIdb) http://www.dgidb.org/downloads DACTINOMYCIN https://www.dgidb.org/drugs/DACTINOMYCIN DrugBank https://www.drugbank.ca/legal/terms_of_use Dactinomycin https://www.drugbank.ca/drugs/DB00970 Therapeutic Target Database (TTD) Dactinomycin http://idrblab.net/ttd/data/drug/details/D0P8IV CAMEO Chemicals https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=false ACTINOMYCIN D https://cameochemicals.noaa.gov/chemical/19722 CAMEO Chemical Reactivity Classification https://cameochemicals.noaa.gov/browse/react ChemIDplus LICENSE https://www.nlm.nih.gov/copyright.html Dactinomycin [USAN:USP:INN:BAN] https://chem.nlm.nih.gov/chemidplus/sid/0000050760 ChemIDplus Chemical Information Classification https://chem.nlm.nih.gov/chemidplus/ EPA DSSTox LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources Actinomycin D https://comptox.epa.gov/dashboard/DTXSID9020031 CompTox Chemicals Dashboard Chemical Lists https://comptox.epa.gov/dashboard/chemical-lists/ European Chemicals Agency (ECHA) https://echa.europa.eu/web/guest/legal-notice Dactinomycin https://echa.europa.eu/substance-information/-/substanceinfo/100.000.058 Dactinomycin https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/88782 FDA Global Substance Registration System (GSRS) https://www.fda.gov/about-fda/about-website/website-policies#linking DACTINOMYCIN https://gsrs.ncats.nih.gov/ginas/app/beta/substances/1CC1JFE158 Hazardous Substances Data Bank (HSDB) DACTINOMYCIN https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3220 Human Metabolome Database (HMDB) http://www.hmdb.ca/citing Dactinomycin http://www.hmdb.ca/metabolites/HMDB0015105 HMDB0015105_msms_2253147 https://hmdb.ca/metabolites/HMDB0015105#spectra ChEBI Actinomycin D http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27666 ChEBI Ontology http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology FDA Pharm Classes https://www.fda.gov/about-fda/about-website/website-policies#linking DACTINOMYCIN https://dailymed.nlm.nih.gov/dailymed/browse-drug-classes.cfm FDA Pharmacological Classification https://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm LiverTox LICENSE https://www.nlm.nih.gov/copyright.html Dactinomycin https://www.ncbi.nlm.nih.gov/books/n/livertox/Dactinomycin/ LOTUS – the natural products occurrence database https://lotus.nprod.net/ dactinomycin https://www.wikidata.org/wiki/Q186127 LOTUS Tree https://lotus.naturalproducts.net/ NCI Thesaurus (NCIt) https://www.cancer.gov/policies/copyright-reuse https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C412 NCI Thesaurus Tree https://ncit.nci.nih.gov CCSbase https://ccsbase.net/ ClinicalTrials.gov https://clinicaltrials.gov/ct2/about-site/terms-conditions#Use https://clinicaltrials.gov/ DailyMed LICENSE https://www.nlm.nih.gov/copyright.html DACTINOMYCIN https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=DACTINOMYCIN Drug Induced Liver Injury Rank (DILIrank) Dataset https://www.fda.gov/about-fda/about-website/website-policies#linking dactinomycin https://www.fda.gov/science-research/liver-toxicity-knowledge-base-ltkb/drug-induced-liver-injury-rank-dilirank-dataset The Natural Products Atlas https://www.npatlas.org/terms Actinomycin D https://www.npatlas.org/explore/compounds/NPA007563 The Natural Products Atlas Classification https://www.npatlas.org/ EU Clinical Trials Register https://www.clinicaltrialsregister.eu/ FDA Orange Book https://www.fda.gov/about-fda/about-website/website-policies#linking https://www.fda.gov/drugs/drug-approvals-and-databases/approved-drug-products-therapeutic-equivalence-evaluations-orange-book National Drug Code (NDC) Directory https://www.fda.gov/about-fda/about-website/website-policies#linking DACTINOMYCIN https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory International Agency for Research on Cancer (IARC) https://publications.iarc.fr/Terms-Of-Use Actinomycin D https://monographs.iarc.who.int/list-of-classifications IARC Classification https://www.iarc.fr/ MassBank of North America (MoNA) LICENSE The content of the MoNA database is licensed under CC BY 4.0. https://mona.fiehnlab.ucdavis.edu/documentation/license Actinomycin D https://mona.fiehnlab.ucdavis.edu/spectra/browse?query=compound.metaData%3Dq%3D%27name%3D%3D%22InChIKey%22%20and%20value%3D%3D%22RJURFGZVJUQBHK-IIXSONLDSA-N%22%27 NCI Cancer Drugs LICENSE https://www.cancer.gov/policies/copyright-reuse Cosmegen (Dactinomycin) https://www.cancer.gov/about-cancer/treatment/drugs/dactinomycin NIPH Clinical Trials Search of Japan https://rctportal.niph.go.jp/en/ NLM RxNorm Terminology https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.html dactinomycin https://rxnav.nlm.nih.gov/id/rxnorm/3100 PubChem https://pubchem.ncbi.nlm.nih.gov Springer Nature https://pubchem.ncbi.nlm.nih.gov/substance/?source=15745&sourceid=90114615-889043108 WHO Anatomical Therapeutic Chemical (ATC) Classification https://www.whocc.no/copyright_disclaimer/ https://www.whocc.no/atc/ ATC Code https://www.whocc.no/atc_ddd_index/ WHO Model Lists of Essential Medicines https://www.who.int/about/who-we-are/publishing-policies/copyright Dactinomycin https://list.essentialmeds.org/medicines/83 Wikidata LICENSE CCZero https://creativecommons.org/publicdomain/zero/1.0/ Dactinomycin https://www.wikidata.org/wiki/Q186127 Wiley https://pubchem.ncbi.nlm.nih.gov/substance/?source=wiley&sourceid=64721 Medical Subject Headings (MeSH) https://www.nlm.nih.gov/copyright.html Dactinomycin https://www.ncbi.nlm.nih.gov/mesh/68003609 MeSH Tree http://www.nlm.nih.gov/mesh/meshhome.html Anti-Bacterial Agents https://www.ncbi.nlm.nih.gov/mesh/68000900 Nucleic Acid Synthesis Inhibitors https://www.ncbi.nlm.nih.gov/mesh/68019384 Protein Synthesis Inhibitors https://www.ncbi.nlm.nih.gov/mesh/68011500 Antibiotics, Antineoplastic https://www.ncbi.nlm.nih.gov/mesh/68000903 UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) GHS Classification Tree http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html NORMAN Suspect List Exchange https://creativecommons.org/licenses/by/4.0/ NORMAN Suspect List Exchange Classification https://www.norman-network.com/nds/SLE/ EPA Substance Registry Services LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources EPA SRS List Classification https://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do PATENTSCOPE (WIPO) SID 388454111 https://pubchem.ncbi.nlm.nih.gov/substance/388454111 NCBI https://www.ncbi.nlm.nih.gov/projects/linkout Show More