Bicalutamide is a nonsteroidal antiandrogen similar in structure to flutamide that is used widely in the therapy of prostate cancer and has been linked to rare instances of liver injury. Bicalutamide is a synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. (NCI04)
Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantiomers. Bicalutamide binds to the androgen receptor.
Mechanism of Action
Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.
Bicalutamide is a nonsteroidal antiandrogen that is structurally and pharmacologically related to flutamide and nilutamide. Bicalutamide inhibits the action of androgens by competitively blocking nuclear androgen receptors in target tissues such as the prostate, seminal vesicles, and adrenal cortex; blockade of androgen receptors in the hormone-sensitive tumor cells may result in growth arrest or transient tumor regression through inhibition of androgen-dependent DNA and protein synthesis. Bicalutamide is a selective antiandrogen with no androgenic or progestational activity in various animal models. The relative binding affinity of bicalutamide at the androgen receptor is more than that of nilutamide and approximately 4 times that of hydroxyflutamide, the active metabolite of flutamide.
Common pharmacologic therapies for prostate cancer (ie, gonadotropin-releasing hormone [GnRH] analogs, nonsteroidal antiandrogens) when used as monotherapy initially result in increased serum testosterone concentrations, which may limit the effects of the drugs. Androgen receptors in the hypothalamus are blocked by bicalutamide, which disrupts the inhibitory feedback of testosterone on luteinizing hormone (LH) release, resulting in a temporary increase in the secretion of LH; the increase in LH stimulates an increase in the production of testosterone. As GnRH analogs have potent GnRH agonist properties, testicular steroidogenesis continues during the first few weeks after initiating therapy. However, the combination of orchiectomy or GnRH analog therapy to suppress testicular androgen production and an antiandrogen to block the response of remaining adrenal androgens provides maximal androgen blockade. Concomitant administration of antiandrogens such as bicalutamide in patients initiating therapy with a GnRH analog can inhibit initial androgenic stimulation and potential exacerbation of symptoms (e.g., bone pain, urinary obstruction, liver pain, impending spinal cord compression) that may occur during the first month of GnRH analog therapy.
Indications
- For treatment (together with surgery or LHRH analog) of advanced prostatic cancer.
- Bicalutamide is a nonsteroidal antiandrogen similar in structure to flutamide that is used widely in the therapy of prostate cancer and has been linked to rare instances of liver injury.
- Bicalutamide/ 50 mg daily is indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate.
Use in Cancer
Bicalutamide is approved to treat:
- Prostate cancer that has metastasized (spread to other parts of the body). It is used with a type of drug called a luteinizing hormone-releasing hormone agonist.
Bicalutamide is also being studied in the treatment of other types of cancer.
Contraindications
- are allergic to bicalutamide or any ingredients of the medication
- have early-stage (localized) prostate cancer and would otherwise undergo watchful waiting
- diabetes
- anemia
- a type of inflammation of the lung called interstitial pneumonitis
- damage to the liver and inflammation
- liver problems
- abnormal liver function tests
- pregnancy
Dosage
Strengths: 50 mg
Prostate Cancer
- In combination with an LHRH analog: 50 mg orally once a day (morning or evening)
Side Effects
The Most Common
- hot flashes or flushing
- bone, back, or pelvic pain
- muscle weakness
- muscle or joint pain
- headache
- shortness of breath
- increased blood pressure
- swelling of the hands, feet, ankles, or lower legs
- cough
- constipation
- nausea
- vomiting
- abdominal pain
- diarrhea
- gas
- change in weight (loss or gain)
- loss of appetite
- dizziness
- pain, burning, or tingling in the hands or feet
- difficulty sleeping
- feeling of uneasiness or dread
- rash
- sweating
- inability to get or keep an erection
- need to urinate frequently during the night
- bloody urine
- painful or difficult urination
- frequent and urgent need to urinate
- difficulty emptying bladder
- painful or swollen breasts
More Common
- yellowing of the skin or eyes
- pain in the upper right part of the stomach
- extreme tiredness
- unusual bleeding or bruising
- lack of energy
- upset stomach
- loss of appetite
- flu-like symptoms
- dull or sharp side pain
- chest pain
- flatulence (passing gas)
- hair loss or decreased hair regrowth
- hot flashes
- impotence or reduction in sexual desire
- increased sensitivity of the skin to sun; increased risk of sunburn
- indigestion
Rare
- abdominal pain
- blood in the urine
- chest pain
- severe itching
- signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
- symptoms of heart failure (e.g., tiredness, shortness of breath especially when lying down, swelling of the feet or ankles)
- pain or tenderness in stomach
- signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
- symptoms of lung problems (e.g., shortness of breath, painful breathing, sudden shortness of breath, cough, fever)
- symptoms of a serious allergic reaction (e.g., hives, shortness of breath, difficulty swallowing, swelling of the face, lips, tongue or throat)
Drug Interaction
| DRUG | INTERACTION |
|---|---|
| Abametapir | The serum concentration of Bicalutamide can be increased when it is combined with Abametapir. |
| Abatacept | The metabolism of Bicalutamide can be increased when combined with Abatacept. |
| Abemaciclib | The metabolism of Abemaciclib can be decreased when combined with Bicalutamide. |
| Acalabrutinib | The metabolism of Acalabrutinib can be decreased when combined with Bicalutamide. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Bicalutamide. |
| Acetaminophen | The metabolism of Bicalutamide can be increased when combined with Acetaminophen. |
| Acetazolamide | The metabolism of Bicalutamide can be decreased when combined with Acetazolamide. |
| Adalimumab | The metabolism of Bicalutamide can be increased when combined with Adalimumab. |
| Albendazole | The metabolism of Bicalutamide can be decreased when combined with Albendazole. |
| Aldesleukin | The metabolism of Bicalutamide can be decreased when combined with Aldesleukin. |
| Alectinib | The metabolism of Alectinib can be decreased when combined with Bicalutamide. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Bicalutamide. |
| Alpelisib | The metabolism of Bicalutamide can be increased when combined with Alpelisib. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Bicalutamide. |
| Aminoglutethimide | The metabolism of Bicalutamide can be increased when combined with Aminoglutethimide. |
| Aminophylline | The metabolism of Aminophylline can be decreased when combined with Bicalutamide. |
| Amiodarone | The metabolism of Bicalutamide can be decreased when combined with Amiodarone. |
| Amitriptyline | The metabolism of Amitriptyline can be decreased when combined with Bicalutamide. |
| Amobarbital | The metabolism of Bicalutamide can be increased when combined with Amobarbital. |
| Amprenavir | The metabolism of Bicalutamide can be decreased when combined with Amprenavir. |
| Anakinra | The metabolism of Bicalutamide can be increased when combined with Anakinra. |
| Apalutamide | The metabolism of Bicalutamide can be increased when combined with Apalutamide. |
| Apremilast | The metabolism of Bicalutamide can be increased when combined with Apremilast. |
| Aprepitant | The metabolism of Bicalutamide can be decreased when combined with Aprepitant. |
| Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Bicalutamide. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be decreased when combined with Bicalutamide. |
| Armodafinil | The metabolism of Bicalutamide can be increased when combined with Armodafinil. |
| Articaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Articaine. |
| Asciminib | The serum concentration of Bicalutamide can be increased when it is combined with Asciminib. |
| Astemizole | The serum concentration of Astemizole can be increased when it is combined with Bicalutamide. |
| Asunaprevir | The metabolism of Bicalutamide can be increased when combined with Asunaprevir. |
| Atazanavir | The metabolism of Bicalutamide can be decreased when combined with Atazanavir. |
| Atomoxetine | The metabolism of Atomoxetine can be decreased when combined with Bicalutamide. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Bicalutamide. |
| Avacopan | The metabolism of Bicalutamide can be decreased when combined with Avacopan. |
| Avanafil | The serum concentration of Avanafil can be increased when it is combined with Bicalutamide. |
| Axitinib | The metabolism of Axitinib can be decreased when combined with Bicalutamide. |
| Azithromycin | The metabolism of Bicalutamide can be decreased when combined with Azithromycin. |
| Beclomethasone | The metabolism of Bicalutamide can be increased when combined with Beclomethasone dipropionate. |
| Belzutifan | The serum concentration of Bicalutamide can be decreased when it is combined with Belzutifan. |
| Benzocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Benzocaine. |
| Benzyl alcohol | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Benzyl alcohol. |
| Berotralstat | The serum concentration of Bicalutamide can be increased when it is combined with Berotralstat. |
| Betamethasone | The metabolism of Bicalutamide can be increased when combined with Betamethasone. |
| Betamethasone | The metabolism of Bicalutamide can be increased when combined with Betamethasone phosphate. |
| Bexarotene | The metabolism of Bicalutamide can be increased when combined with Bexarotene. |
| Bifonazole | The metabolism of Bicalutamide can be decreased when combined with Bifonazole. |
| Bimekizumab | The metabolism of Bicalutamide can be increased when combined with Bimekizumab. |
| Boceprevir | The metabolism of Bicalutamide can be decreased when combined with Boceprevir. |
| Bortezomib | The metabolism of Bortezomib can be decreased when combined with Bicalutamide. |
| Bosentan | The metabolism of Bicalutamide can be increased when combined with Bosentan. |
| Bosutinib | The metabolism of Bosutinib can be decreased when combined with Bicalutamide. |
| Brentuximab vedotin | The metabolism of Brentuximab vedotin can be decreased when combined with Bicalutamide. |
| Brigatinib | The metabolism of Brigatinib can be decreased when combined with Bicalutamide. |
| Budesonide | The metabolism of Bicalutamide can be increased when combined with Budesonide. |
| Bupivacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Bupivacaine. |
| Buprenorphine | The metabolism of Bicalutamide can be decreased when combined with Buprenorphine. |
| Busulfan | The metabolism of Busulfan can be decreased when combined with Bicalutamide. |
| Butacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Butacaine. |
| Butalbital | The metabolism of Bicalutamide can be increased when combined with Butalbital. |
| Butamben | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Butamben. |
| Cabazitaxel | The metabolism of Cabazitaxel can be decreased when combined with Bicalutamide. |
| Cabergoline | The metabolism of Cabergoline can be decreased when combined with Bicalutamide. |
| Calcitriol | The metabolism of Bicalutamide can be increased when combined with Calcitriol. |
| Canakinumab | The metabolism of Bicalutamide can be increased when combined with Canakinumab. |
| Candicidin | The metabolism of Bicalutamide can be decreased when combined with Candicidin. |
| Cannabidiol | The metabolism of Bicalutamide can be decreased when combined with Cannabidiol. |
| Capromab pendetide | Bicalutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent. |
| Capsaicin | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Capsaicin. |
| Carbamazepine | The metabolism of Bicalutamide can be increased when combined with Carbamazepine. |
| Cefradine | The metabolism of Bicalutamide can be increased when combined with Cefradine. |
| Cenobamate | The serum concentration of Bicalutamide can be decreased when it is combined with Cenobamate. |
| Cephalexin | The metabolism of Bicalutamide can be decreased when combined with Cephalexin. |
| Ceritinib | The metabolism of Ceritinib can be decreased when combined with Bicalutamide. |
| Cerivastatin | The metabolism of Bicalutamide can be increased when combined with Cerivastatin. |
| Certolizumab pegol | The metabolism of Bicalutamide can be increased when combined with Certolizumab pegol. |
| Chloramphenicol | The metabolism of Bicalutamide can be decreased when combined with Chloramphenicol. |
| Chloroprocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Chloroprocaine. |
| Chlorpromazine | The metabolism of Bicalutamide can be increased when combined with Chlorpromazine. |
| Choline C 11 | Bicalutamide may decrease effectiveness of Choline C 11 as a diagnostic agent. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Bicalutamide. |
| Cimetidine | The metabolism of Bicalutamide can be decreased when combined with Cimetidine. |
| Cinchocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Cinchocaine. |
| Ciprofloxacin | The metabolism of Bicalutamide can be decreased when combined with Ciprofloxacin. |
| Cisapride | The metabolism of Bicalutamide can be decreased when combined with Cisapride. |
| Citalopram | The metabolism of Bicalutamide can be decreased when combined with Citalopram. |
| Clarithromycin | The metabolism of Bicalutamide can be decreased when combined with Clarithromycin. |
| Clevidipine | The metabolism of Bicalutamide can be increased when combined with Clevidipine. |
| Clobazam | The metabolism of Bicalutamide can be increased when combined with Clobazam. |
| Clobetasol propionate | The metabolism of Bicalutamide can be increased when combined with Clobetasol propionate. |
| Clofazimine | The metabolism of Bicalutamide can be decreased when combined with Clofazimine. |
| Clofibrate | The metabolism of Bicalutamide can be increased when combined with Clofibrate. |
| Clomipramine | The metabolism of Clomipramine can be decreased when combined with Bicalutamide. |
| Clonidine | The metabolism of Clonidine can be decreased when combined with Bicalutamide. |
| Clozapine | The metabolism of Bicalutamide can be increased when combined with Clozapine. |
| Cobicistat | The metabolism of Bicalutamide can be decreased when combined with Cobicistat. |
| Cobimetinib | The metabolism of Cobimetinib can be decreased when combined with Bicalutamide. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Cocaine. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Bicalutamide. |
| Conivaptan | The metabolism of Bicalutamide can be decreased when combined with Conivaptan. |
| Copanlisib | The metabolism of Copanlisib can be decreased when combined with Bicalutamide. |
| Corticotropin | The metabolism of Bicalutamide can be increased when combined with Corticotropin. |
| Cortisone acetate | The metabolism of Bicalutamide can be increased when combined with Cortisone acetate. |
| Crizotinib | The metabolism of Bicalutamide can be decreased when combined with Crizotinib. |
| Curcumin | The metabolism of Bicalutamide can be decreased when combined with Curcumin. |
| Cyclophosphamide | The metabolism of Bicalutamide can be increased when combined with Cyclophosphamide. |
| Cyclosporine | The metabolism of Bicalutamide can be decreased when combined with Cyclosporine. |
| Cyproterone acetate | The metabolism of Bicalutamide can be decreased when combined with Cyproterone acetate. |
| Dabrafenib | The serum concentration of Bicalutamide can be decreased when it is combined with Dabrafenib. |
| Dacomitinib | The metabolism of Dacomitinib can be decreased when combined with Bicalutamide. |
| Dalfopristin | The metabolism of Bicalutamide can be decreased when combined with Dalfopristin. |
| Danazol | The metabolism of Bicalutamide can be decreased when combined with Danazol. |
| Darbepoetin alfa | The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bicalutamide. |
| Darunavir | The serum concentration of Bicalutamide can be increased when it is combined with Darunavir. |
| Dasatinib | The metabolism of Dasatinib can be decreased when combined with Bicalutamide. |
| Daunorubicin | The metabolism of Bicalutamide can be decreased when combined with Daunorubicin. |
| Deferasirox | The metabolism of Bicalutamide can be increased when combined with Deferasirox. |
| Deflazacort | The metabolism of Bicalutamide can be increased when combined with Deflazacort. |
| Delavirdine | The metabolism of Bicalutamide can be decreased when combined with Delavirdine. |
| Desipramine | The metabolism of Bicalutamide can be decreased when combined with Desipramine. |
| Desvenlafaxine | The metabolism of Bicalutamide can be decreased when combined with Desvenlafaxine. |
| Dexamethasone | The metabolism of Bicalutamide can be increased when combined with Dexamethasone. |
| Dexamethasone acetate | The metabolism of Bicalutamide can be increased when combined with Dexamethasone acetate. |
| Dextropropoxyphene | The metabolism of Bicalutamide can be decreased when combined with Dextropropoxyphene. |
| Dicloxacillin | The metabolism of Bicalutamide can be increased when combined with Dicloxacillin. |
| Diethylstilbestrol | The metabolism of Bicalutamide can be decreased when combined with Diethylstilbestrol. |
| Difluocortolone | The metabolism of Bicalutamide can be increased when combined with Difluocortolone. |
| Digitoxin | The metabolism of Digitoxin can be decreased when combined with Bicalutamide. |
| Dihydroergocornine | The metabolism of Bicalutamide can be decreased when combined with Dihydroergocornine. |
| Dihydroergocristine | The metabolism of Bicalutamide can be decreased when combined with Dihydroergocristine. |
| Dihydroergotamine | The metabolism of Dihydroergotamine can be decreased when combined with Bicalutamide. |
| Diltiazem | The metabolism of Bicalutamide can be decreased when combined with Diltiazem. |
| Dimethyl sulfoxide | The metabolism of Bicalutamide can be decreased when combined with Dimethyl sulfoxide. |
| Diosmin | The metabolism of Bicalutamide can be decreased when combined with Diosmin. |
| Diphenhydramine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Diphenhydramine. |
| Docetaxel | The metabolism of Docetaxel can be decreased when combined with Bicalutamide. |
| Dofetilide | The metabolism of Dofetilide can be decreased when combined with Bicalutamide. |
| Doxazosin | The metabolism of Bicalutamide can be decreased when combined with Doxazosin. |
| Doxorubicin | The metabolism of Doxorubicin can be decreased when combined with Bicalutamide. |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Bicalutamide. |
| Dronedarone | The serum concentration of Bicalutamide can be increased when it is combined with Dronedarone. |
| Drospirenone | The metabolism of Bicalutamide can be decreased when combined with Drospirenone. |
| Duvelisib | The metabolism of Bicalutamide can be decreased when combined with Duvelisib. |
| Dyclonine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Dyclonine. |
| Ebastine | The metabolism of Bicalutamide can be decreased when combined with Ebastine. |
| Echinacea | The metabolism of Bicalutamide can be increased when combined with Echinacea. |
| Efavirenz | The metabolism of Bicalutamide can be decreased when combined with Efavirenz. |
| Elexacaftor | The metabolism of Bicalutamide can be decreased when combined with Elexacaftor. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Bicalutamide. |
| Elvitegravir | The metabolism of Bicalutamide can be decreased when combined with Elvitegravir. |
| Emapalumab | The metabolism of Bicalutamide can be increased when combined with Emapalumab. |
| Enasidenib | The metabolism of Bicalutamide can be increased when combined with Enasidenib. |
| Entrectinib | The metabolism of Entrectinib can be decreased when combined with Bicalutamide. |
| Enzalutamide | The serum concentration of Bicalutamide can be decreased when it is combined with Enzalutamide. |
| Epinephrine | The metabolism of Bicalutamide can be decreased when combined with Epinephrine. |
| Erdafitinib | The metabolism of Erdafitinib can be decreased when combined with Bicalutamide. |
| Ergotamine | The metabolism of Bicalutamide can be decreased when combined with Ergotamine. |
| Erlotinib | The metabolism of Erlotinib can be decreased when combined with Bicalutamide. |
| Erythromycin | The metabolism of Bicalutamide can be decreased when combined with Erythromycin. |
| Erythropoietin | The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Bicalutamide. |
| Esketamine | The metabolism of Bicalutamide can be increased when combined with Esketamine. |
| Eslicarbazepine | The metabolism of Bicalutamide can be increased when combined with Eslicarbazepine. |
| Eslicarbazepine acetate | The metabolism of Bicalutamide can be increased when combined with Eslicarbazepine acetate. |
| Estetrol | The metabolism of Bicalutamide can be decreased when combined with Estetrol. |
| Estradiol acetate | The metabolism of Bicalutamide can be increased when combined with Estradiol acetate. |
| Estradiol benzoate | The metabolism of Bicalutamide can be increased when combined with Estradiol benzoate. |
| Estradiol cypionate | The metabolism of Bicalutamide can be increased when combined with Estradiol cypionate. |
| Estradiol dienanthate | The metabolism of Bicalutamide can be increased when combined with Estradiol dienanthate. |
| Estradiol valerate | The metabolism of Bicalutamide can be increased when combined with Estradiol valerate. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Bicalutamide. |
| Etanercept | The metabolism of Bicalutamide can be increased when combined with Etanercept. |
| Ethambutol | The metabolism of Bicalutamide can be decreased when combined with Ethambutol. |
| Ethanol | The metabolism of Bicalutamide can be increased when combined with Ethanol. |
| Ethyl chloride | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Ethyl chloride. |
| Etidocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Etidocaine. |
| Etoposide | The metabolism of Etoposide can be decreased when combined with Bicalutamide. |
| Etoricoxib | The metabolism of Bicalutamide can be decreased when combined with Etoricoxib. |
| Etravirine | The metabolism of Bicalutamide can be increased when combined with Etravirine. |
| Everolimus | The metabolism of Everolimus can be decreased when combined with Bicalutamide. |
| Felbamate | The metabolism of Bicalutamide can be increased when combined with Felbamate. |
| Fenofibrate | The metabolism of Bicalutamide can be decreased when combined with Fenofibrate. |
| Fentanyl | The metabolism of Fentanyl can be decreased when combined with Bicalutamide. |
| Fexinidazole | The metabolism of Bicalutamide can be decreased when combined with Fexinidazole. |
| Finerenone | The serum concentration of Finerenone can be increased when it is combined with Bicalutamide. |
| Flucloxacillin | The metabolism of Bicalutamide can be increased when combined with Flucloxacillin. |
| Fluconazole | The metabolism of Bicalutamide can be decreased when combined with Fluconazole. |
| Flunisolide | The metabolism of Bicalutamide can be increased when combined with Flunisolide. |
| Fluocinolone acetonide | The metabolism of Bicalutamide can be increased when combined with Fluocinolone acetonide. |
| Fluocinonide | The metabolism of Bicalutamide can be increased when combined with Fluocinonide. |
| Fluocortolone | The metabolism of Bicalutamide can be increased when combined with Fluocortolone. |
| Fluoxetine | The metabolism of Bicalutamide can be decreased when combined with Fluoxetine. |
| Fluticasone | The metabolism of Bicalutamide can be increased when combined with Fluticasone. |
| Fluticasone furoate | The metabolism of Bicalutamide can be increased when combined with Fluticasone furoate. |
| Fluticasone propionate | The metabolism of Bicalutamide can be decreased when combined with Fluticasone propionate. |
| Fluvoxamine | The metabolism of Bicalutamide can be decreased when combined with Fluvoxamine. |
| Formestane | The metabolism of Bicalutamide can be increased when combined with Formestane. |
| Fosamprenavir | The metabolism of Bicalutamide can be decreased when combined with Fosamprenavir. |
| Fosaprepitant | The metabolism of Bicalutamide can be increased when combined with Fosaprepitant. |
| Fosnetupitant | The metabolism of Bicalutamide can be decreased when combined with Fosnetupitant. |
| Fosphenytoin | The metabolism of Bicalutamide can be increased when combined with Fosphenytoin. |
| Fostamatinib | The metabolism of Bicalutamide can be decreased when combined with Fostamatinib. |
| Fusidic acid | The metabolism of Bicalutamide can be decreased when combined with Fusidic acid. |
| Gallium Ga-68 gozetotide | Bicalutamide may increase effectiveness of Gallium Ga-68 gozetotide as a diagnostic agent. |
| Gilteritinib | The metabolism of Bicalutamide can be decreased when combined with Gilteritinib. |
| Ginkgo biloba | The metabolism of Bicalutamide can be decreased when combined with Ginkgo biloba. |
| Glecaprevir | The metabolism of Bicalutamide can be decreased when combined with Glecaprevir. |
| Glyburide | The metabolism of Bicalutamide can be decreased when combined with Glyburide. |
| Glycerol phenylbutyrate | The metabolism of Bicalutamide can be increased when combined with Glycerol phenylbutyrate. |
| Golimumab | The metabolism of Bicalutamide can be increased when combined with Golimumab. |
| Griseofulvin | The metabolism of Bicalutamide can be increased when combined with Griseofulvin. |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Bicalutamide. |
| Hydralazine | The metabolism of Bicalutamide can be decreased when combined with Hydralazine. |
| Hydrocortamate | The metabolism of Bicalutamide can be increased when combined with Hydrocortamate. |
| Hydrocortisone | The metabolism of Bicalutamide can be increased when combined with Hydrocortisone. |
| Hydrocortisone acetate | The metabolism of Bicalutamide can be increased when combined with Hydrocortisone acetate. |
| Hydrocortisone butyrate | The metabolism of Bicalutamide can be increased when combined with Hydrocortisone butyrate. |
| Hydrocortisone | The metabolism of Bicalutamide can be increased when combined with Hydrocortisone succinate. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Bicalutamide. |
| Idelalisib | The metabolism of Idelalisib can be decreased when combined with Bicalutamide. |
| Ifosfamide | The metabolism of Bicalutamide can be increased when combined with Ifosfamide. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Bicalutamide. |
| Imatinib | The serum concentration of Bicalutamide can be increased when it is combined with Imatinib. |
| Indinavir | The metabolism of Bicalutamide can be decreased when combined with Indinavir. |
| Infigratinib | The metabolism of Bicalutamide can be decreased when combined with Infigratinib. |
| Infliximab | The metabolism of Bicalutamide can be increased when combined with Infliximab. |
| Irbesartan | The metabolism of Bicalutamide can be decreased when combined with Irbesartan. |
| Irinotecan | The metabolism of Irinotecan can be decreased when combined with Bicalutamide. |
| Isavuconazole | The metabolism of Bicalutamide can be increased when combined with Isavuconazole. |
| Isavuconazonium | The metabolism of Bicalutamide can be increased when combined with Isavuconazonium. |
| Isoniazid | The metabolism of Bicalutamide can be decreased when combined with Isoniazid. |
| Isradipine | The metabolism of Bicalutamide can be decreased when combined with Isradipine. |
| Itraconazole | The metabolism of Bicalutamide can be decreased when combined with Itraconazole. |
| Ivacaftor | The metabolism of Bicalutamide can be decreased when combined with Ivacaftor. |
| Ivosidenib | The metabolism of Bicalutamide can be increased when combined with Ivosidenib. |
| Ixabepilone | The metabolism of Ixabepilone can be decreased when combined with Bicalutamide. |
| Ixazomib | The metabolism of Ixazomib can be decreased when combined with Bicalutamide. |
| Ketazolam | The metabolism of Bicalutamide can be decreased when combined with Ketazolam. |
| Ketoconazole | The metabolism of Bicalutamide can be decreased when combined with Ketoconazole. |
| Lacosamide | The metabolism of Bicalutamide can be decreased when combined with Lacosamide. |
| Lanreotide | The metabolism of Bicalutamide can be decreased when combined with Lanreotide. |
| Lapatinib | The metabolism of Bicalutamide can be decreased when combined with Lapatinib. |
| Lefamulin | The serum concentration of Bicalutamide can be increased when it is combined with Lefamulin. |
| Lesinurad | The metabolism of Bicalutamide can be increased when combined with Lesinurad. |
| Letermovir | The metabolism of Bicalutamide can be decreased when combined with Letermovir. |
| Levacetylmethadol | The metabolism of Levacetylmethadol can be decreased when combined with Bicalutamide. |
| Levamlodipine | The serum concentration of Levamlodipine can be increased when it is combined with Bicalutamide. |
| Levobupivacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Levobupivacaine. |
| Levoketoconazole | The metabolism of Bicalutamide can be decreased when combined with Levoketoconazole. |
| Lidocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Lidocaine. |
| Linagliptin | The metabolism of Bicalutamide can be decreased when combined with Linagliptin. |
| Lomitapide | The metabolism of Lomitapide can be decreased when combined with Bicalutamide. |
| Lonafarnib | The metabolism of Bicalutamide can be decreased when combined with Lonafarnib. |
| Lopinavir | The metabolism of Bicalutamide can be decreased when combined with Lopinavir. |
| Lorlatinib | The metabolism of Bicalutamide can be increased when combined with Lorlatinib. |
| Losartan | The metabolism of Bicalutamide can be decreased when combined with Losartan. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Bicalutamide. |
| Lumacaftor | The metabolism of Bicalutamide can be increased when combined with Lumacaftor. |
| Manidipine | The metabolism of Bicalutamide can be decreased when combined with Manidipine. |
| Mavacamten | The serum concentration of Bicalutamide can be decreased when it is combined with Mavacamten. |
| Medroxyprogesterone | The metabolism of Bicalutamide can be increased when combined with Medroxyprogesterone acetate. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Meloxicam. |
| Meperidine | The metabolism of Bicalutamide can be decreased when combined with Meperidine. |
| Mepivacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Mepivacaine. |
| Meprednisone | The metabolism of Bicalutamide can be increased when combined with Meprednisone. |
| Methadone | The metabolism of Bicalutamide can be decreased when combined with Methadone. |
| Methimazole | The metabolism of Bicalutamide can be decreased when combined with Methimazole. |
| Methotrexate | The metabolism of Methotrexate can be decreased when combined with Bicalutamide. |
| Methoxy polyethylene | The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bicalutamide. |
| Methylene blue | The metabolism of Bicalutamide can be decreased when combined with Methylene blue. |
| Methylergometrine | The metabolism of Bicalutamide can be decreased when combined with Methylergometrine. |
| Methylphenobarbital | The metabolism of Bicalutamide can be increased when combined with Methylphenobarbital. |
| Methylprednisolone | The metabolism of Bicalutamide can be increased when combined with Methylprednisolone. |
| Methylprednisone | The metabolism of Bicalutamide can be decreased when combined with Methylprednisone. |
| Methysergide | The metabolism of Bicalutamide can be decreased when combined with Methysergide. |
| Metreleptin | The metabolism of Bicalutamide can be increased when combined with Metreleptin. |
| Metronidazole | The metabolism of Bicalutamide can be decreased when combined with Metronidazole. |
| Metyrapone | The metabolism of Bicalutamide can be increased when combined with Metyrapone. |
| Miconazole | The metabolism of Bicalutamide can be decreased when combined with Miconazole. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Bicalutamide. |
| Midostaurin | The metabolism of Bicalutamide can be decreased when combined with Midostaurin. |
| Mifepristone | The metabolism of Bicalutamide can be increased when combined with Mifepristone. |
| Milnacipran | The metabolism of Bicalutamide can be decreased when combined with Milnacipran. |
| Miocamycin | The metabolism of Bicalutamide can be decreased when combined with Miocamycin. |
| Mirtazapine | The metabolism of Bicalutamide can be decreased when combined with Mirtazapine. |
| Mitapivat | The metabolism of Bicalutamide can be increased when combined with Mitapivat. |
| Mitotane | The metabolism of Bicalutamide can be increased when combined with Mitotane. |
| Mobocertinib | The serum concentration of Bicalutamide can be decreased when it is combined with Mobocertinib. |
| Modafinil | The metabolism of Bicalutamide can be increased when combined with Modafinil. |
| Mometasone furoate | The metabolism of Bicalutamide can be increased when combined with Mometasone furoate. |
| Mosunetuzumab | The metabolism of Bicalutamide can be decreased when combined with Mosunetuzumab. |
| Nafcillin | The metabolism of Bicalutamide can be increased when combined with Nafcillin. |
| Naloxone | The metabolism of Bicalutamide can be decreased when combined with Naloxone. |
| Nefazodone | The metabolism of Bicalutamide can be decreased when combined with Nefazodone. |
| Nelfinavir | The metabolism of Bicalutamide can be decreased when combined with Nelfinavir. |
| Neratinib | The metabolism of Neratinib can be decreased when combined with Bicalutamide. |
| Netupitant | The metabolism of Bicalutamide can be decreased when combined with Netupitant. |
| Niacin | The metabolism of Bicalutamide can be decreased when combined with Niacin. |
| Nicardipine | The metabolism of Bicalutamide can be decreased when combined with Nicardipine. |
| Nilotinib | The metabolism of Bicalutamide can be decreased when combined with Nilotinib. |
| Nilvadipine | The metabolism of Bicalutamide can be decreased when combined with Nilvadipine. |
| Nintedanib | The metabolism of Bicalutamide can be decreased when combined with Nintedanib. |
| Norethisterone | The metabolism of Bicalutamide can be decreased when combined with Norethisterone. |
| Norgestimate | The metabolism of Bicalutamide can be increased when combined with Norgestimate. |
| Nortriptyline | The metabolism of Nortriptyline can be decreased when combined with Bicalutamide. |
| Noscapine | The metabolism of Bicalutamide can be decreased when combined with Noscapine. |
| Octreotide | The serum concentration of Bicalutamide can be increased when it is combined with Octreotide. |
| Olaparib | The metabolism of Olaparib can be decreased when combined with Bicalutamide. |
| Omeprazole | The metabolism of Bicalutamide can be increased when combined with Omeprazole. |
| Oritavancin | The metabolism of Bicalutamide can be increased when combined with Oritavancin. |
| Orphenadrine | The metabolism of Bicalutamide can be decreased when combined with Orphenadrine. |
| Osilodrostat | The metabolism of Bicalutamide can be decreased when combined with Osilodrostat. |
| Osimertinib | The metabolism of Osimertinib can be decreased when combined with Bicalutamide. |
| Oxcarbazepine | The metabolism of Bicalutamide can be increased when combined with Oxcarbazepine. |
| Oxetacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Oxetacaine. |
| Oxybuprocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Oxybuprocaine. |
| Oxybutynin | The metabolism of Bicalutamide can be decreased when combined with Oxybutynin. |
| Paclitaxel | The metabolism of Bicalutamide can be increased when combined with Paclitaxel. |
| Pacritinib | The serum concentration of Bicalutamide can be increased when it is combined with Pacritinib. |
| Palbociclib | The metabolism of Palbociclib can be decreased when combined with Bicalutamide. |
| Panobinostat | The metabolism of Panobinostat can be decreased when combined with Bicalutamide. |
| Pasireotide | The metabolism of Bicalutamide can be decreased when combined with Pasireotide. |
| Pazopanib | The metabolism of Pazopanib can be decreased when combined with Bicalutamide. |
| Peginesatide | The risk or severity of Thrombosis can be increased when Peginesatide is combined with Bicalutamide. |
| Pentobarbital | The metabolism of Bicalutamide can be increased when combined with Pentobarbital. |
| Perampanel | The metabolism of Bicalutamide can be increased when combined with Perampanel. |
| Pexidartinib | The metabolism of Pexidartinib can be decreased when combined with Bicalutamide. |
| Phenobarbital | The metabolism of Bicalutamide can be increased when combined with Phenobarbital. |
| Phenol | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Phenol. |
| Phenprocoumon | The metabolism of Phenprocoumon can be decreased when combined with Bicalutamide. |
| Phenylbutazone | The metabolism of Bicalutamide can be increased when combined with Phenylbutazone. |
| Phenytoin | The metabolism of Bicalutamide can be increased when combined with Phenytoin. |
| Piflufolastat F 18 | Bicalutamide may decrease effectiveness of Piflufolastat F 18 as a diagnostic agent. |
| Pimavanserin | The metabolism of Bicalutamide can be decreased when combined with Pimavanserin. |
| Pimozide | The metabolism of Pimozide can be decreased when combined with Bicalutamide. |
| Piperaquine | The metabolism of Bicalutamide can be decreased when combined with Piperaquine. |
| Pitolisant | The serum concentration of Bicalutamide can be decreased when it is combined with Pitolisant. |
| Pomalidomide | The metabolism of Pomalidomide can be decreased when combined with Bicalutamide. |
| Ponatinib | The metabolism of Ponatinib can be decreased when combined with Bicalutamide. |
| Posaconazole | The metabolism of Bicalutamide can be decreased when combined with Posaconazole. |
| Pralsetinib | The metabolism of Bicalutamide can be increased when combined with Pralsetinib. |
| Pramocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Pramocaine. |
| Prednisolone | The metabolism of Bicalutamide can be increased when combined with Prednisolone. |
| Prednisolone acetate | The metabolism of Bicalutamide can be increased when combined with Prednisolone acetate. |
| Prednisolone phosphate | The metabolism of Bicalutamide can be increased when combined with Prednisolone phosphate. |
| Prednisone acetate | The metabolism of Bicalutamide can be increased when combined with Prednisone acetate. |
| Pretomanid | The metabolism of Bicalutamide can be decreased when combined with Pretomanid. |
| Prilocaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Prilocaine. |
| Primaquine | The metabolism of Bicalutamide can be decreased when combined with Primaquine. |
| Primidone | The metabolism of Bicalutamide can be increased when combined with Primidone. |
| Probenecid | The metabolism of Bicalutamide can be increased when combined with Probenecid. |
| Procaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Procaine. |
| Proparacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Proparacaine. |
| Propofol | The metabolism of Bicalutamide can be decreased when combined with Propofol. |
| Propoxycaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Propoxycaine. |
| Propranolol | The serum concentration of Propranolol can be increased when it is combined with Bicalutamide. |
| Prucalopride | The metabolism of Prucalopride can be decreased when combined with Bicalutamide. |
| Quinidine | The metabolism of Bicalutamide can be decreased when combined with Quinidine. |
| Quinine | The metabolism of Bicalutamide can be increased when combined with Quinine. |
| Quinupristin | The metabolism of Bicalutamide can be decreased when combined with Quinupristin. |
| Raloxifene | The metabolism of Bicalutamide can be decreased when combined with Raloxifene. |
| Ranolazine | The metabolism of Bicalutamide can be decreased when combined with Ranolazine. |
| Regorafenib | The metabolism of Regorafenib can be decreased when combined with Bicalutamide. |
| Remdesivir | The metabolism of Bicalutamide can be decreased when combined with Remdesivir. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Bicalutamide. |
| Ribociclib | The metabolism of Bicalutamide can be decreased when combined with Ribociclib. |
| Rifabutin | The metabolism of Bicalutamide can be increased when combined with Rifabutin. |
| Rifampicin | The metabolism of Bicalutamide can be increased when combined with Rifampicin. |
| Rifamycin | The metabolism of Bicalutamide can be increased when combined with Rifamycin. |
| Rifapentine | The metabolism of Bicalutamide can be increased when combined with Rifapentine. |
| Rilonacept | The metabolism of Bicalutamide can be increased when combined with Rilonacept. |
| Rilpivirine | The metabolism of Bicalutamide can be decreased when combined with Rilpivirine. |
| Ritonavir | The serum concentration of Bicalutamide can be increased when it is combined with Ritonavir. |
| Rofecoxib | The metabolism of Bicalutamide can be increased when combined with Rofecoxib. |
| Roflumilast | The serum concentration of Roflumilast can be increased when it is combined with Bicalutamide. |
| Romidepsin | The metabolism of Romidepsin can be decreased when combined with Bicalutamide. |
| Ropivacaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Ropivacaine. |
| Rosuvastatin | The metabolism of Bicalutamide can be decreased when combined with Rosuvastatin. |
| Roxithromycin | The metabolism of Bicalutamide can be decreased when combined with Roxithromycin. |
| Rucaparib | The metabolism of Bicalutamide can be decreased when combined with Rucaparib. |
| Rufinamide | The metabolism of Bicalutamide can be increased when combined with Rufinamide. |
| Ruxolitinib | The metabolism of Ruxolitinib can be decreased when combined with Bicalutamide. |
| Saquinavir | The metabolism of Bicalutamide can be decreased when combined with Saquinavir. |
| Sarilumab | The metabolism of Bicalutamide can be increased when combined with Sarilumab. |
| Satralizumab | The serum concentration of Bicalutamide can be decreased when it is combined with Satralizumab. |
| Secobarbital | The metabolism of Bicalutamide can be increased when combined with Secobarbital. |
| Secukinumab | The metabolism of Bicalutamide can be increased when combined with Secukinumab. |
| Siltuximab | The metabolism of Bicalutamide can be increased when combined with Siltuximab. |
| Simeprevir | The metabolism of Bicalutamide can be decreased when combined with Simeprevir. |
| Siponimod | The metabolism of Siponimod can be decreased when combined with Bicalutamide. |
| Sirolimus | The metabolism of Sirolimus can be decreased when combined with Bicalutamide. |
| Sitaxentan | The metabolism of Bicalutamide can be decreased when combined with Sitaxentan. |
| Somatostatin | The metabolism of Bicalutamide can be decreased when combined with Somatostatin. |
| Somatrogon | The metabolism of Bicalutamide can be increased when combined with Somatrogon. |
| Sonidegib | The metabolism of Sonidegib can be decreased when combined with Bicalutamide. |
| Sorafenib | The metabolism of Sorafenib can be decreased when combined with Bicalutamide. |
| Sotorasib | The serum concentration of Bicalutamide can be decreased when it is combined with Sotorasib. |
| St. John’s Wort | The metabolism of Bicalutamide can be increased when combined with St. John’s Wort. |
| Stiripentol | The metabolism of Bicalutamide can be decreased when combined with Stiripentol. |
| Sulfamethoxazole | The metabolism of Bicalutamide can be decreased when combined with Sulfamethoxazole. |
| Sulfinpyrazone | The metabolism of Bicalutamide can be increased when combined with Sulfinpyrazone. |
| Sunitinib | The metabolism of Sunitinib can be decreased when combined with Bicalutamide. |
| Suvorexant | The metabolism of Bicalutamide can be decreased when combined with Suvorexant. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Bicalutamide. |
| Tamoxifen | The metabolism of Bicalutamide can be increased when combined with Tamoxifen. |
| Tasimelteon | The metabolism of Bicalutamide can be decreased when combined with Tasimelteon. |
| Tazemetostat | The metabolism of Bicalutamide can be decreased when combined with Tazemetostat. |
| Tecovirimat | The metabolism of Bicalutamide can be increased when combined with Tecovirimat. |
| Telaprevir | The metabolism of Bicalutamide can be decreased when combined with Telaprevir. |
| Telithromycin | The metabolism of Bicalutamide can be decreased when combined with Telithromycin. |
| Telotristat ethyl | The serum concentration of Bicalutamide can be decreased when it is combined with Telotristat ethyl. |
| Temsirolimus | The metabolism of Temsirolimus can be decreased when combined with Bicalutamide. |
| Teniposide | The metabolism of Teniposide can be decreased when combined with Bicalutamide. |
| Tenofovir alafenamide | The metabolism of Bicalutamide can be decreased when combined with Tenofovir alafenamide. |
| Terbinafine | The metabolism of Bicalutamide can be increased when combined with Terbinafine. |
| Terfenadine | The serum concentration of Terfenadine can be increased when it is combined with Bicalutamide. |
| Testosterone | The metabolism of Bicalutamide can be increased when combined with Testosterone. |
| Tetracaine | The risk or severity of methemoglobinemia can be increased when Bicalutamide is combined with Tetracaine. |
| Tetracycline | The metabolism of Bicalutamide can be decreased when combined with Tetracycline. |
| Theophylline | The metabolism of Theophylline can be decreased when combined with Bicalutamide. |
| Thiamylal | The metabolism of Bicalutamide can be increased when combined with Thiamylal. |
| Thiotepa | The metabolism of Thiotepa can be decreased when combined with Bicalutamide. |
| Ticagrelor | The metabolism of Bicalutamide can be decreased when combined with Ticagrelor. |
| Timolol | The metabolism of Timolol can be decreased when combined with Bicalutamide. |
| Tipranavir | The metabolism of Bicalutamide can be decreased when combined with Tipranavir. |
| Tocilizumab | The metabolism of Bicalutamide can be increased when combined with Tocilizumab. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Bicalutamide. |
| Tolvaptan | The metabolism of Tolvaptan can be decreased when combined with Bicalutamide. |
| Topiramate | The metabolism of Bicalutamide can be increased when combined with Topiramate. |
| Trabectedin | The metabolism of Trabectedin can be decreased when combined with Bicalutamide. |
| Tramadol | The metabolism of Tramadol can be decreased when combined with Bicalutamide. |
| Trastuzumab emtansine | The metabolism of Trastuzumab emtansine can be decreased when combined with Bicalutamide. |
| Triamcinolone | The metabolism of Bicalutamide can be increased when combined with Triamcinolone. |
| Triclabendazole | The metabolism of Bicalutamide can be decreased when combined with Triclabendazole. |
| Troglitazone | The metabolism of Bicalutamide can be increased when combined with Troglitazone. |
| Troleandomycin | The metabolism of Bicalutamide can be decreased when combined with Troleandomycin. |
| Tucatinib | The metabolism of Tucatinib can be decreased when combined with Bicalutamide. |
| Ubrogepant | The serum concentration of Ubrogepant can be increased when it is combined with Bicalutamide. |
| Valproic acid | The metabolism of Bicalutamide can be decreased when combined with Valproic acid. |
| Vandetanib | The metabolism of Vandetanib can be decreased when combined with Bicalutamide. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Bicalutamide. |
| Vemurafenib | The metabolism of Bicalutamide can be increased when combined with Vemurafenib. |
| Venetoclax | The metabolism of Bicalutamide can be decreased when combined with Venetoclax. |
| Verapamil | The metabolism of Bicalutamide can be decreased when combined with Verapamil. |
| Viloxazine | The metabolism of Bicalutamide can be decreased when combined with Viloxazine. |
| Vinblastine | The metabolism of Bicalutamide can be increased when combined with Vinblastine. |
| Vincristine | The metabolism of Vincristine can be decreased when combined with Bicalutamide. |
| Vindesine | The metabolism of Vindesine can be decreased when combined with Bicalutamide. |
| Vinflunine | The metabolism of Vinflunine can be decreased when combined with Bicalutamide. |
| Vinorelbine | The metabolism of Vinorelbine can be decreased when combined with Bicalutamide. |
| Vitamin E | The metabolism of Bicalutamide can be increased when combined with Vitamin E. |
| Vorapaxar | The metabolism of Bicalutamide can be decreased when combined with Vorapaxar. |
| Voriconazole | The metabolism of Bicalutamide can be decreased when combined with Voriconazole. |
| Voxelotor | The serum concentration of Bicalutamide can be increased when it is combined with Voxelotor. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Bicalutamide. |
| Zafirlukast | The metabolism of Bicalutamide can be decreased when combined with Zafirlukast. |
| Zanubrutinib | The metabolism of Zanubrutinib can be decreased when combined with Bicalutamide. |
| Zimelidine | The metabolism of Bicalutamide can be decreased when combined with Zimelidine. |
| Ziprasidone | The metabolism of Bicalutamide can be decreased when combined with Ziprasidone. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Bicalutamide. |
| Zuclopenthixol | The metabolism of Bicalutamide can be decreased when combined with Zuclopenthixol. |
Pregnancy and Lactation
US FDA pregnancy category: Not assigned.
Pregnancy
This drug is contraindicated in females. This drug is contraindicated in pregnant women because it can cause fetal harm. Drugs that have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects. Accompanying texts should be consulted for further details.
Breastfeeding
This drug is contraindicated in females; therefore, it is contraindicated in lactation. Excreted into human milk: Unknown
Excreted into animal milk: Yes
The effects in the nursing infant are unknown.
How should this medicine be used?
Bicalutamide comes as a tablet to take by mouth. It is usually taken with or without food once a day, either in the morning or evening. Take bicalutamide at around the same time every day. You should begin taking bicalutamide on the same day you begin injecting the luteinizing hormone-releasing hormone. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bicalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Bicalutamide along with the luteinizing hormone-releasing hormone may help stop the growth and spread of cancer cells but does not cure prostate cancer. Continue to take both bicalutamide and the luteinizing hormone-releasing hormone even if you feel better. Do not stop taking these medications without talking to your doctor.
What special precautions should I follow?
Before taking bicalutamide,
- tell your doctor and pharmacist if you are allergic to bicalutamide, any other medications, or any of the ingredients in bicalutamide tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); anticoagulants (‘blood thinners’) such as warfarin (Coumadin); aripiprazole (Abilify); buspirone (Buspar); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan); chlorpheniramine; cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); diazepam (Valium); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Invirase, Fortovase); methadone (Dolophine); midazolam (Versed); pimozide (Orap); quinidine (Quinidex, Quinaglute); quinine; sildenafil (Viagra); tacrolimus (Prograf); tamoxifen (Nolvadex); telithromycin (Ketek); trazodone (Desyrel); triazolam (Halcion); and vincristine (Vincasar). Many other medications may also interact with bicalutamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have or have ever had liver disease.
- you should know that bicalutamide is only for use in men. If taken by pregnant women, bicalutamide can cause abnormalities in the fetus. Women who are or may become pregnant should not take bicalutamide. If you take bicalutamide while you are pregnant, call your doctor immediately.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Abnormal heart rhythm: Bicalutamide can cause changes to the normal rhythm of the heart, called QT prolongation. QT prolongation is a serious life-threatening condition. If you are at risk for heart rhythm problems (e.g., have heart failure, angina, low potassium or magnesium levels; have congenital long QT syndrome; or are taking medications that can prolong the QT interval, such as quinidine, procainamide, amiodarone, sotalol, flecainide), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Anemia: Bicalutamide may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.
Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.
Diabetes: Bicalutamide may cause an increase in blood sugar levels. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication.
If you have diabetes or are at risk for developing diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Drowsiness/reduced alertness: This medication may cause drowsiness. Do not drive, operate machinery, or perform other hazardous tasks until you have determined how this medication affects you.
Heart disease: The risk of heart attack or heart failure is increased for people taking bicalutamide. If you have risk factors for heart disease (obesity, high blood cholesterol, smoking), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: Bicalutamide is broken down by the liver. Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
This medication may also cause liver problems. Contact your doctor immediately if you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin.
Lung disease: Rarely, and particularly when higher doses are used, cases of interstitial lung disease have been reported with this medication. If you experience any symptoms of lung problems such as breathing difficulties, wheezing, cough, fever, or shortness of breath, contact your doctor immediately.
Osteoporosis: Long-term use of bicalutamide has been shown to cause reduced bone strength and may increase the risk of bone fractures. If you have osteoporosis or are at increased risk of developing osteoporosis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Sensitivity to sunlight: This medication may increase the sensitivity of the skin to sunlight, increasing the risk of sunburn. Avoid exposure to sunlight for long periods of time, particularly between the hours of 10 am and 2 pm, while you are taking this medication and for 7 days after completing treatment. Wear a broad-spectrum sunscreen and lip balm with an SPF of 50 or greater. If you notice any unusual skin rash or peeling, contact your doctor immediately.
Children: The safety and effectiveness of this medication have not been determined for children.
References
