Desmoplastic Melanoma

Desmoplastic melanoma is a rare and unique form of skin cancer that requires special attention and understanding. In this article, we’ll break down everything you need to know about desmoplastic melanoma in simple language, from its types and causes to its symptoms, diagnostic tests, treatments, and medications.

Types of Desmoplastic Melanoma:

Desmoplastic melanoma has two main types:

  1. Superficial Desmoplastic Melanoma: This type typically starts on the skin’s surface and then grows deeper into the tissue.
  2. Nodular Desmoplastic Melanoma: Unlike the superficial type, nodular desmoplastic melanoma begins in the deeper layers of the skin right away.

Causes of Desmoplastic Melanoma:

  1. Sun Exposure: Prolonged exposure to the sun’s harmful ultraviolet (UV) rays is a major risk factor for desmoplastic melanoma.
  2. Genetics: If you have a family history of melanoma or a genetic predisposition to skin cancer, your risk may be higher.
  3. Fair Skin: People with fair skin, light hair, and blue or green eyes are more susceptible to desmoplastic melanoma.
  4. Age: This cancer is more common in older adults, although it can affect people of all ages.
  5. Immune System Suppression: Conditions or medications that weaken your immune system can increase your risk.
  6. Previous Melanoma: If you’ve had melanoma before, you have a higher chance of developing desmoplastic melanoma.
  7. Gender: Men are more likely to develop desmoplastic melanoma than women.
  8. Geographic Location: Living in areas with high sun exposure can increase your risk.
  9. Occupational Exposure: Certain jobs that involve outdoor work may increase the risk of desmoplastic melanoma.
  10. Chemical Exposure: Exposure to certain chemicals can also be a risk factor.

Symptoms of Desmoplastic Melanoma:

  1. Skin Lesion: Desmoplastic melanoma often appears as a firm, raised, or flat lesion on the skin.
  2. Color Changes: The lesion may have varying shades of brown, black, or blue.
  3. Irregular Borders: The borders of the lesion may be uneven or irregular.
  4. Size: The lesion may grow larger over time.
  5. Itchiness: Some people experience itching or discomfort in the affected area.
  6. Bleeding or Crusting: The lesion may bleed, ooze, or develop a crust.
  7. Rapid Growth: Desmoplastic melanoma can grow quickly.
  8. Lack of Pigmentation: In some cases, the lesion may be pale or flesh-colored.
  9. Nail Changes: When it occurs on the fingers or toes, desmoplastic melanoma can cause changes in the nails.
  10. Swelling or Ulceration: In advanced stages, the lesion may become swollen or form an ulcer.

Diagnostic Tests for Desmoplastic Melanoma:

  1. Skin Biopsy: A sample of the suspicious lesion is taken and examined under a microscope to confirm the diagnosis.
  2. Dermoscopy: This involves using a specialized tool to examine the skin lesion in detail.
  3. Sentinel Lymph Node Biopsy: If the cancer has spread, a biopsy of nearby lymph nodes may be necessary.
  4. Imaging Tests: X-rays, CT scans, or MRI scans can help determine the extent of the cancer.
  5. Lymph Node Biopsy: If lymph nodes are enlarged, a biopsy may be performed to check for cancer spread.
  6. PET Scan: This scan can help identify distant metastases if the cancer has spread.
  7. Blood Tests: Blood tests may be done to check for elevated levels of certain markers associated with melanoma.
  8. Genetic Testing: Some cases of desmoplastic melanoma may undergo genetic testing to guide treatment decisions.
  9. Lymphoscintigraphy: This test can help locate sentinel lymph nodes for biopsy.
  10. Skin Mapping: In some cases, the entire area of skin where the lesion is located is mapped to guide treatment.

Treatments for Desmoplastic Melanoma:

  1. Surgery: The primary treatment for desmoplastic melanoma is surgical removal of the lesion and surrounding tissue.
  2. Mohs Micrographic Surgery: This precise surgical technique removes cancer while preserving healthy tissue.
  3. Radiation Therapy: Radiation may be used after surgery to kill any remaining cancer cells.
  4. Immunotherapy: Drugs like pembrolizumab and nivolumab can boost the immune system to fight cancer.
  5. Targeted Therapy: Targeted drugs like dabrafenib and trametinib may be used for specific genetic mutations.
  6. Chemotherapy: While less common, chemotherapy may be used for advanced cases.
  7. Clinical Trials: Patients may consider participating in clinical trials for experimental treatments.
  8. Lymph Node Dissection: If cancer has spread to lymph nodes, they may be surgically removed.
  9. Adjuvant Therapy: Additional treatment may be given to reduce the risk of cancer recurrence.
  10. Palliative Care: This focuses on symptom management and improving quality of life for advanced cases.

Medications for Desmoplastic Melanoma:

  1. Pembrolizumab (Keytruda): An immunotherapy drug that can boost the immune system’s ability to fight cancer.
  2. Nivolumab (Opdivo): Another immunotherapy drug that targets cancer cells.
  3. Dabrafenib (Tafinlar): A targeted therapy drug for certain genetic mutations in melanoma.
  4. Trametinib (Mekinist): Often used in combination with dabrafenib for specific mutations.
  5. Vemurafenib (Zelboraf): Targeted therapy for certain BRAF gene mutations.
  6. Ipilimumab (Yervoy): An immunotherapy drug that works differently than PD-1 inhibitors.
  7. Interferon: A medication that can boost the immune system’s response to cancer.
  8. Temozolomide (Temodar): A chemotherapy drug used in some cases.
  9. Bevacizumab (Avastin): A targeted therapy drug that inhibits blood vessel growth in tumors.
  10. Talimogene Laherparepvec (T-VEC): An immunotherapy drug injected directly into melanoma lesions.

Conclusion:

Desmoplastic melanoma is a complex and rare skin cancer that requires early detection and appropriate treatment. Understanding its types, causes, symptoms, diagnostic tests, treatments, and medications is crucial for patients and their caregivers. If you suspect you may have desmoplastic melanoma or are at risk, consult a healthcare professional for guidance and personalized care. Early intervention and awareness can make a significant difference in managing this condition.

 

Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.

  1. https://medlineplus.gov/skinconditions.html
  2. https://www.aad.org/about/burden-of-skin-disease
  3. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  4. https://www.cdc.gov/niosh/topics/skin/default.html
  5. https://www.skincancer.org/
  6. https://illnesshacker.com/
  7. https://endinglines.com/
  8. https://www.jaad.org/
  9. https://www.psoriasis.org/about-psoriasis/
  10. https://books.google.com/books?
  11. https://www.niams.nih.gov/health-topics/skin-diseases
  12. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  13. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  14. https://dermnetnz.org/topics
  15. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  16. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  17. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  18. https://www.nibib.nih.gov/
  19. https://rxharun.com/rxharun/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/
  20. https://www.nei.nih.gov/
  21. https://en.wikipedia.org/wiki/List_of_skin_conditions
  22. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  23. https://en.wikipedia.org/wiki/Skin_condition
  24. https://oxfordtreatment.com/
  25. https://www.nidcd.nih.gov/health/
  26. https://consumer.ftc.gov/articles/w
  27. https://www.nccih.nih.gov/health
  28. https://catalog.ninds.nih.gov/
  29. https://www.aarda.org/diseaselist/
  30. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  31. https://www.nibib.nih.gov/
  32. https://www.nia.nih.gov/health/topics
  33. https://www.nichd.nih.gov/
  34. https://www.nimh.nih.gov/health/topics
  35. https://www.nichd.nih.gov/
  36. https://www.niehs.nih.gov
  37. https://www.nimhd.nih.gov/
  38. https://www.nhlbi.nih.gov/health-topics
  39. https://obssr.od.nih.gov/
  40. https://www.nichd.nih.gov/health/topics
  41. https://rarediseases.info.nih.gov/diseases
  42. https://beta.rarediseases.info.nih.gov/diseases
  43. https://orwh.od.nih.gov/

References