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Occipitofrontalis Muscle Cancer

Dr. Carolyn J. Agresti, MD - Otolaryngologist (ENT) Dr. Carolyn J. Agresti, MD - Otolaryngologist (ENT)
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Rx Musculoskeletal System (A - Z)

Occipitofrontalis muscle cancer is a very rare form of soft-tissue sarcoma that arises in the epicranius (occipitofrontalis) muscle covering the scalp. Like other muscle-based cancers, it most often presents as a subtype of rhabdomyosarcoma or other soft-tissue sarcoma. Early recognition and a multidisciplinary approach to diagnosis and treatment are essential for improving outcomes. Below is a comprehensive, plain-English, SEO-friendly overview covering all aspects of this condition.

Anatomy of the Occipitofrontalis Muscle

  • Structure & Location
    The occipitofrontalis (epicranius) is a paired, broad, thin muscle overlying the skull. It has two bellies—frontal and occipital—connected by the epicranial (galea) aponeurosis. It covers the forehead and posterior skull WikipediaKenhub.

  • Origin

    • Frontal belly: intermediate tendon on the epicranial aponeurosis Wikipedia

    • Occipital belly: superior nuchal line of the occipital bone and mastoid region of the temporal bone Wikipediawww.elsevier.com

  • Insertion

    • Frontal belly: skin of the eyebrows and root of nose Wikipedia

    • Occipital belly: epicranial aponeurosis Wikipedia

  • Blood Supply

    • Frontal belly: supraorbital and supratrochlear arteries (branches of ophthalmic artery) and frontal branch of superficial temporal artery WikipediaKenhub

    • Occipital belly: occipital artery and posterior auricular branches (from external carotid system) KenhubRadiopaedia

  • Nerve Supply
    Innervation is via the facial nerve (CN VII):

  • Functions (6 key actions)

    1. Raises the eyebrows Wikipedia

    2. Wrinkles the forehead skin Wikipedia

    3. Retracts the scalp (occipital belly) Study.com

    4. Assists in facial expression of surprise Home

    5. Helps with eyebrow movement during emoting Wikipedia

    6. Stabilizes galea aponeurotica for other scalp muscles Wikipédia, l’encyclopédie libre

Types of Occipitofrontalis Muscle Cancer

Most tumors of the occipitofrontalis muscle are classified under soft-tissue sarcomas, especially rhabdomyosarcomas, because they arise from muscle cells. Major types include:

  1. Embryonal Rhabdomyosarcoma (ERMS)

    • Most common subtype in children (around 60% of cases) PMCCancer Research UK

    • Often arises in head and neck, including scalp

  2. Alveolar Rhabdomyosarcoma (ARMS)

    • Accounts for ~20% of cases; more aggressive with quicker spread PMC

    • More common in adolescents and young adults

  3. Pleomorphic Rhabdomyosarcoma

  4. Spindle Cell and Botryoid Subtypes

    • Variants of ERMS with unique microscopic features and prognosis PMC

  5. Other Soft-Tissue Sarcoma Variants

    • Leiomyosarcoma, liposarcoma, undifferentiated pleomorphic sarcoma may rarely involve the epicranius Home

Causes and Risk Factors

  1. Genetic Syndromes

    • Li-Fraumeni syndrome PMC

    • Beckwith-Wiedemann syndrome PMC

  2. Neurofibromatosis type 1 PMC

  3. Costello syndrome PMC

  4. Noonan syndrome PMC

  5. Recklinghausen disease PMC

  6. Prior radiation exposure (therapeutic or accidental) Mayo Clinic

  7. Parental smoking (father’s smoking linked to RMS) Home

  8. Chemical exposures (vinyl chloride, herbicides) Home

  9. Immunosuppression (e.g., post‐transplant) Mayo Clinic

  10. Advanced age (for pleomorphic subtype) Cleveland Clinic

  11. Male sex (slightly higher incidence in boys) PMC

  12. Chronic lymphedema Home

  13. Ultraviolet (UV) exposure (scalp sun exposure) Home

  14. Human papillomavirus (HPV) (possible link in head/neck cancers) Home

  15. Human immunodeficiency virus (HIV) Mayo Clinic

  16. Epstein-Barr virus (EBV) (in some soft-tissue tumors) Mayo Clinic

  17. Inherited DNA repair defects PMC

  18. Environmental pollution Home

  19. Obesity (pro-inflammatory state) Home

  20. Chronic scalp infections (promote abnormal cell growth) Mayo Clinic

Symptoms

Depending on tumor size and location, patients may experience:

  1. A firm, painless lump on the scalp Mayo Clinic

  2. Rapid growth of the lump Mayo Clinic

  3. Localized pain or tenderness Cleveland Clinic

  4. Swelling or visible bulge Mayo Clinic

  5. Scalp ulceration or skin changes Mayo Clinic

  6. Hair loss over the tumor Cleveland Clinic

  7. Headaches (if compressing skull) Radiopaedia

  8. Numbness or tingling in scalp Radiopaedia

  9. Facial asymmetry (if spreading) Radiopaedia

  10. Vision changes (if orbital extension) Cleveland Clinic

  11. Ear pain or discharge (if para‐auricular spread) Cleveland Clinic

  12. Bleeding or oozing from lesion Mayo Clinic

  13. Fever (paraneoplastic) Cleveland Clinic

  14. Night sweats Cleveland Clinic

  15. Unexplained weight loss Cleveland Clinic

  16. Fatigue Cleveland Clinic

  17. Enlarged lymph nodes in head/neck Mayo Clinic

  18. Difficulty swallowing (if deep extension) Radiopaedia

  19. Hoarseness (if compressing laryngeal nerves) Radiopaedia

  20. General malaise Cleveland Clinic

Diagnostic Tests

  1. Clinical examination Mayo Clinic

  2. Skin ultrasound Radiopaedia

  3. X-ray of skull Radiopaedia

  4. CT scan of head and neck Radiopaedia

  5. MRI with contrast Radiopaedia

  6. PET-CT scan Radiopaedia

  7. Core-needle biopsy Mayo Clinic

  8. Excisional biopsy Mayo Clinic

  9. Histopathology (H&E stain) PMC

  10. Immunohistochemistry (myogenin, desmin) PMC

  11. Cytogenetics (PAX-FOXO1 fusion detection) PMC

  12. FISH analysis PMC

  13. Flow cytometry PMC

  14. CBC & metabolic panel Cleveland Clinic

  15. Liver function tests Cleveland Clinic

  16. Kidney function tests Cleveland Clinic

  17. Bone scan Radiopaedia

  18. Bone marrow biopsy (if metastasis suspected) PMC

  19. Echocardiogram (pre-chemo assessment) Cleveland Clinic

  20. Chest CT (lung metastasis check) Cleveland Clinic

Non-Pharmacological Treatments

(Note: These include both curative and supportive modalities beyond drug therapy.)

  1. External-beam radiotherapy Home

  2. Brachytherapy Home

  3. Proton therapy Home

  4. Stereotactic radiosurgery Home

  5. Hyperthermia therapy Home

  6. Cryoablation Home

  7. Radiofrequency ablation Home

  8. Photodynamic therapy Home

  9. Thermal ablation (HIFU) Home

  10. Surgical wide local excision (also detailed in surgery) Home

  11. Reconstructive flap surgery PMC

  12. Physical therapy (maintain scalp mobility) Mayo Clinic

  13. Occupational therapy (daily living support) Mayo Clinic

  14. Speech/swallow therapy Radiopaedia

  15. Nutritional counseling Cleveland Clinic

  16. Psychological counseling Cleveland Clinic

  17. Massage therapy Mayo Clinic

  18. Acupuncture (pain relief) Mayo Clinic

  19. Mindfulness & meditation Mayo Clinic

  20. Yoga & tai chi Mayo Clinic

  21. Art/music therapy Cleveland Clinic

  22. Support groups Cleveland Clinic

  23. Palliative care services Cleveland Clinic

  24. Hospice care Cleveland Clinic

  25. Lymphedema therapy Mayo Clinic

  26. Skin care & wound management Mayo Clinic

  27. Pain management techniques (TENS, relaxation) Mayo Clinic

  28. Occupational scalp prosthetics Cleveland Clinic

  29. Nurse-led care coordination Cleveland Clinic

  30. Telemedicine follow‐up Cleveland Clinic

 Drugs (Chemotherapy & Targeted Agents)

  1. Vincristine Cleveland Clinic

  2. Actinomycin D (Dactinomycin) Cleveland Clinic

  3. Cyclophosphamide Cleveland Clinic

  4. Ifosfamide Cleveland Clinic

  5. Doxorubicin Cleveland Clinic

  6. Etoposide Cleveland Clinic

  7. Cisplatin Cleveland Clinic

  8. Carboplatin Cleveland Clinic

  9. Irinotecan Cleveland Clinic

  10. Temozolomide Cleveland Clinic

  11. Topotecan Cleveland Clinic

  12. Vinblastine Cleveland Clinic

  13. Vinorelbine Cleveland Clinic

  14. Bleomycin Cleveland Clinic

  15. Pirarubicin Cleveland Clinic

  16. Pazopanib (TKI) Home

  17. Sorafenib (TKI) Home

  18. Imatinib (for PDGFR-positive sarcoma) Home

  19. Bevacizumab (anti-VEGF) Home

  20. Temsirolimus (mTOR inhibitor) Home

Surgical Procedures

  1. Wide local excision (complete tumor removal with margins) Home

  2. Mohs micrographic surgery (layer-by-layer margin control) Home

  3. Craniotomy with en bloc resection (for bone‐invasive tumors) Radiopaedia

  4. Reconstructive flap surgery (scalp defect repair) PMC

  5. Free tissue transfer (microvascular flap) PMC

  6. Sentinel lymph node biopsy Mayo Clinic

  7. Neck dissection (regional lymph node removal) Radiopaedia

  8. Debulking surgery (for symptom relief) Cleveland Clinic

  9. Excisional biopsy (diagnostic and therapeutic) Mayo Clinic

  10. Craniofacial resection (extensive head and neck involvement) Radiopaedia

Prevention Strategies

  1. Minimize therapeutic radiation when possible Mayo Clinic

  2. Avoid tobacco smoke exposure Home

  3. Wear sun protection to limit UV on scalp Home

  4. Screen for genetic syndromes in high-risk families PMC

  5. Regular scalp examinations (self and physician) Mayo Clinic

  6. Reduce chemical exposures (industrial, agricultural) Home

  7. Maintain healthy weight Home

  8. Vaccinate against HPV where indicated Home

  9. Manage chronic infections of scalp promptly Mayo Clinic

  10. Promote occupational safety (protective gear) Home

When to See a Doctor

Promptly consult a healthcare provider if you notice:

Frequently Asked Questions

  1. What is occipitofrontalis muscle cancer?
    A rare sarcoma arising in the epicranius muscle on the scalp. Penn Medicine

  2. How common is this cancer?
    Extremely rare—most scalp sarcomas are <1% of all soft-tissue sarcomas. Penn Medicine

  3. Who is at risk?
    Children with genetic syndromes; prior radiation exposure; males slightly more. PMCHome

  4. What are early symptoms?
    A painless scalp lump that grows over weeks or months. Mayo Clinic

  5. How is it diagnosed?
    Imaging (MRI/CT), biopsy, histology, and genetic tests. Radiopaedia

  6. Can it spread?
    Yes—through blood to lungs or bones and via lymph nodes. PMC

  7. What treatments are available?
    Surgery, radiotherapy, chemotherapy, and supportive care. Home

  8. What is the prognosis?
    Depends on subtype and stage; 5-year survival up to 70% in localized cases. PMC

  9. Are there side effects of treatment?
    Hair loss, skin changes, fatigue, nausea, and risk of secondary tumors. Cleveland Clinic

  10. How can I cope with treatment?
    Supportive therapies like nutrition, physiotherapy, and counseling help. Cleveland Clinic

  11. Is genetic testing useful?
    Yes—for diagnosing subtypes and guiding family counseling. PMC

  12. Can it recur?
    Recurrence risk exists; regular follow-up imaging is essential. PMC

  13. What follow-up is needed?
    Periodic MRI/CT, chest imaging, blood tests, and physical exams. Cleveland Clinic

  14. Are there clinical trials?
    Yes—many centers offer trials of novel drugs and immunotherapies. Home

  15. Where can I find support?
    Cancer support groups, sarcoma foundations, and specialized centers. Cleveland Clinic

Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, geological location, weather and previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. Regular check-ups and awareness can help to manage and prevent complications associated with these diseases conditions. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. We always try to ensure that the content is regularly updated to reflect the latest medical research and treatment options. Thank you for giving your valuable time to read the article.

The article is written by Team Rxharun and reviewed by the Rx Editorial Board Members

Last Updated: April 27, 2025.

  1. https://pubmed.ncbi.nlm.nih.gov/27887750/
  2. https://www.ncbi.nlm.nih.gov/books/NBK537139/
  3. https://www.ncbi.nlm.nih.gov/books/NBK537236/
  4. https://www.ncbi.nlm.nih.gov/books/NBK537140/
  5. https://pubmed.ncbi.nlm.nih.gov/30335291/
  6. https://pubmed.ncbi.nlm.nih.gov/30725921/
  7. https://pubmed.ncbi.nlm.nih.gov/30725824/
  8. https://www.ncbi.nlm.nih.gov/books/NBK559006/
  9. https://pubmed.ncbi.nlm.nih.gov/30725825/
  10. https://en.wikipedia.org/wiki/Muscle
  11. https://en.wikipedia.org/wiki/List_of_skeletal_muscles_of_the_human_body
  12. https://medlineplus.gov/ency/imagepages/19841.htm
  13. https://www.britannica.com/science/human-muscle-system
  14. https://training.seer.cancer.gov/anatomy/muscular/types.html
  15. https://www.britannica.com/science/human-muscle-system
  16. https://www.sciencedirect.com/topics/medicine-and-dentistry/skeletal-muscle
  17. https://academic.oup.com/nar/article/32/5/1792/2380623
  18. https://onlinelibrary.wiley.com/journal/10974598
  19. https://medlineplus.gov/skinconditions.html
  20. https://en.wikipedia.org/wiki/Category:Kidney_diseases
  21. https://kidney.org.au/your-kidneys/what-is-kidney-disease/types-of-kidney-disease
  22. https://www.niddk.nih.gov/health-information/kidney-disease
  23. https://www.kidney.org/kidney-topics/chronic-kidney-disease-ckd
  24. https://www.kidneyfund.org/all-about-kidneys/types-kidney-diseases
  25. https://www.aad.org/about/burden-of-skin-disease
  26. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  27. https://www.cdc.gov/niosh/topics/skin/default.html
  28. https://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/syc-20350084
  29. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understanding-Sleep
  30. https://www.cdc.gov/traumaticbraininjury/index.html
  31. https://www.skincancer.org/
  32. https://illnesshacker.com/
  33. https://endinglines.com/
  34. https://www.jaad.org/
  35. https://www.psoriasis.org/about-psoriasis/
  36. https://books.google.com/books?
  37. https://www.niams.nih.gov/health-topics/skin-diseases
  38. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  39. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  40. https://dermnetnz.org/topics
  41. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  42. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  43. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  44. https://www.nibib.nih.gov/
  45. https://www.nei.nih.gov/
  46. https://en.wikipedia.org/wiki/List_of_skin_conditions
  47. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  48. https://en.wikipedia.org/wiki/Skin_condition
  49. https://oxfordtreatment.com/
  50. https://www.nidcd.nih.gov/health/
  51. https://consumer.ftc.gov/articles/w
  52. https://www.nccih.nih.gov/health
  53. https://catalog.ninds.nih.gov/
  54. https://www.aarda.org/diseaselist/
  55. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  56. https://www.nibib.nih.gov/
  57. https://www.nia.nih.gov/health/topics
  58. https://www.nichd.nih.gov/
  59. https://www.nimh.nih.gov/health/topics
  60. https://www.nichd.nih.gov/
  61. https://www.niehs.nih.gov
  62. https://www.nimhd.nih.gov/
  63. https://www.nhlbi.nih.gov/health-topics
  64. https://obssr.od.nih.gov/
  65. https://www.nichd.nih.gov/health/topics
  66. https://rarediseases.info.nih.gov/diseases
  67. https://beta.rarediseases.info.nih.gov/diseases
  68. https://orwh.od.nih.gov/

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