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Azithromycin – Uses, Dosage, Side Effects, Interactions

Dr. Harun Ar Rashid, MD - Arthritis, Bones, Joints Pain, Trauma, and Internal Medicine Specialist Dr. Harun Ar Rashid, MD - Arthritis, Bones, Joints Pain, Trauma, and Internal Medicine Specialist
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Drugs (A - Z), Rx Journal of Fitness & Clinical Research
  • Mechanism of Action of Azithromycin
  • Indications of Azithromycin
  • Contraindication of Azithromycin
  • Dosage of Azithromycin
  • Side Effects of Azithromycin
  • Drug Interactions of Azithromycin
  • FAQ

Azithromycin is a semi-synthetic macrolide antibiotic structurally derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. It has been used in the treatment of Mycobacterium avium intracellular infections, toxoplasmosis, and cryptosporidiosis. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death. Azithromycin is an antibiotic useful for the treatment of a number of bacterial infections. This includes middle ear infections, strep throat, pneumonia, traveler’s diarrhea, and certain other intestinal infections. It may also be used for a number of sexually transmitted infections including chlamydia and gonorrhea infections.

Mechanism of Action of Azithromycin

Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes and therefore inhibits RNA-dependent protein synthesis in bacterial cells.
Azithromycin usually is bacteriostatic, although the drug may be bactericidal in high concentrations against selected organisms. Bactericidal activity has been observed in vitro against Streptococcus pyogenes, S. pneumoniae, and Haemophilus influenzae. Azithromycin inhibits protein synthesis in susceptible organisms by penetrating the cell wall and binding to 50S ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis. The site of action of azithromycin appears to be the same as that of the macrolides (i.e., erythromycin, clarithromycin), clindamycin, lincomycin, and chloramphenicol. The antimicrobial activity of azithromycin is reduced at low pH. Azithromycin concentrates in phagocytes, including polymorphonuclear leukocytes, monocytes, macrophages, and fibroblasts. Penetration of the drug into phagocytic cells is necessary for activity against intracellular pathogens (e.g., Staphylococcus aureus, Legionella pneumophila, Chlamydia trachomatis, Salmonella typhi).

Indications of Azithromycin

  • Acute bacterial sinusitis (adequately diagnosed)
  • Acute bacterial otitis media (adequately diagnosed)
  • Pharyngitis, tonsillitis
  • Acute exacerbation of chronic bronchitis (adequately diagnosed)
  • Mild to moderately severe community-acquired pneumonia
  • Skin and soft tissue infections
  • Uncomplicated Chlamydia trachomatis urethritis and cervicitis
  • Legionella Pneumonia
  • Mycoplasma Pneumonia
  • Pneumonia
  • Tonsillitis/Pharyngitis
  • Sinusitis
  • Skin and Structure Infection
  • Gonococcal Infection – Uncomplicated
  • Nongonococcal Urethritis
  • Chlamydia Infection
  • Cervicitis
  • Chancroid
  • Pelvic Inflammatory Disease
  • Chronic Obstructive Pulmonary Disease
  • Bronchitis
  • Mycobacterium avium-intracellular
  • Granuloma Inguinale
  • STD Prophylaxis
  • Pertussis Prophylaxis
  • Pertussis
  • Lyme Disease – Erythema Chronicum Migrans
  • Babesiosis
  • Bacterial Endocarditis Prophylaxis
  • Toxoplasmosis
  • Campylobacter Gastroenteritis
  • Upper Respiratory Tract Infection

Contraindication of Azithromycin

  • History of severe hypersensitivity (e.g. anaphylactic reaction) to any other type of betalactam antibacterial agent (penicillins, monobactams and carbapenems).
  • Hemolytic anemia
  • Liver problems
  • Interstitial nephritis
  • Subacute cutaneous lupus erythematosus
  • Systemic lupus erythematosus
  • Allergies macl& betalactams
  • Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic. Coadministration w/ pimozide. History of cholestatic jaundice/hepatic dysfunction associated w/ prior use of azithromycin.

Dosage of Azithromycin

Strengths: 250 mg, 500 mg, 600 mg; 1 g; 2 g; 2.5 g I.V; 100 mg/5 mL; 200 mg/5 mL Suspension

Chronic Obstructive Pulmonary Disease

Immediate-release

  • 500 mg orally once a day for 3 days OR 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5

Pneumonia

Immediate-release

  • 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5

Extended-release

  • 2 g orally once as a single dose
  • Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy

Upper Respiratory Tract Infection

ASBMT and IDSA Recommendations

Bacterial infections within the first 100 days of HCT

Immediate-release

  • Alternative treatment: 250 mg orally once a day
  • Prevention of bacterial infections for HCT patients with anticipated neutropenic periods of at least 7 days

Tonsillitis/Pharyngitis

Immediate-release

  • 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5

IDSA Recommendations
Immediate-release

  • Individuals with penicillin allergy: 12 mg/kg orally once a day
  • Maximum dose: 500 mg/day
  • Duration of therapy: 5 days

 Skin and Structure Infection

Immediate-release

  • 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5

IDSA and NIH Recommendations
Immediate-release

  • Patients greater than 45 kg: 500 mg orally on day 1, then 250 mg orally once a day on days 2 through 5
  • Patients less than 45 kg: 10 mg/kg orally on day 1, then 5 mg/kg orally once a day for 4 additional days
  • Alternative therapy for Bartonella infections (not endocarditis or central nervous system infections): 500 mg orally once a day for at least 3 months

Community-acquired pneumonia

Immediate-release

  • 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5

Extended-release

  • 2 g orally once as a single dose
  • Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy

Sinusitis

Immediate-release

  • 500 mg orally once a day for 3 days

Extended-release

  • 2 g orally once as a single dose

Pelvic Inflammatory Disease

  • 500 mg IV once a day for 1 or 2 days, followed by 250 mg (immediate-release formulation) orally once a day to complete a 7-day course of therapy.

Pediatric Pneumonia

6 months and older

Immediate-release

  • 10 mg/kg (maximum: 500 mg/dose) orally on day 1, followed by 5 mg/kg (250 mg/dose) orally once a day on days 2 to 5

Extended-release

  • Patients less than 34 kg: 60 mg/kg (maximum dose: 2 g/dose) orally as a single dose
  • Patients 34 kg or greater: 2 g orally as a single dose

16 years and older

  • Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy

IDSA and Pediatric Infectious Disease Society (PIDS) Recommendations

3 months to less than 5 years

  • Parenteral: 10 mg/kg on days 1 and 2 of treatment, transitioning to oral treatment when possible
  • Oral: 10 mg/kg orally on day 1, then 5 mg/kg/day orally once a day on days 2 to 5

5 years and older

  • Oral: 10 mg/kg (maximum: 500 mg/day) orally on day 1, followed by 5 mg/kg/day
  • maximum: 250 mg/day orally on days 2 to 5

Pediatric Mycoplasma Pneumonia

6 months and older

Immediate-release

  • 10 mg/kg (maximum: 500 mg/dose) orally on day 1, followed by 5 mg/kg (250 mg/dose) orally once a day on days 2 to 5

Extended-release

  • Patients less than 34 kg: 60 mg/kg (maximum dose: 2 g/dose) orally as a single dose
  • Patients 34 kg or greater: 2 g orally as a single dose

16 years and older

  • Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy

IDSA and Pediatric Infectious Disease Society (PIDS) Recommendations
3 months to less than 5 years

  • Parenteral: 10 mg/kg on days 1 and 2 of treatment, transitioning to oral treatment when possible
  • Oral: 10 mg/kg orally on day 1, then 5 mg/kg/day orally once a day on days 2 to 5

5 years and older

  • Oral: 10 mg/kg (maximum: 500 mg/day) orally on day 1, followed by 5 mg/kg/day
  • maximum: 250 mg/day orally on days 2 to 5

Tonsillitis/Pharyngitis

2 years and older

  • Immediate-release: 12 mg/kg (maximum: 500 mg/dose) orally once a day for 5 days

Pediatric, Bacterial Infection

American Academy of Pediatrics (AAP) Recommendations

Immediate-release, Less than 1 month

  • IV: 10 mg/kg IV every 24 hours
  • Oral: 10 to 20 mg/kg orally every 24 hours

1 month or older

  • Mild to moderate infections: 5 to 12 mg/kg orally once a day
  • Severe infections: 10 mg/kg IV once a day

Skin and Structure Infection

IDSA Recommendations,

Immediate-release

  • Patients greater than 45 kg: 500 mg orally on day 1, then 250 mg orally once a day on days 2 through 5
  • Patients less than 45 kg: 10 mg/kg orally on day 1, then 5 mg/kg orally once a day for 4 additional days

Side Effects of Azithromycin

Most common

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • leukopenia/leukemia
  • hemolytic anemia
  • serum sickness
  • agranulocytosis
  • pain, swelling, irritation where injected
  • stomach upset
  • sweating
  • skin color change, mild diarrhea
  • mild nausea
  • loss of appetite
  • vaginal discharge and itching
  • swelling of feet or legs
  • chest pain
  • constipation
  • cough
  • diarrhea or loose stools
  • difficulty with breathing
  • dizziness
  • heartburn

More common

  • Abdominal or stomach pain, discomfort, or tenderness
  • chills or fever
  • difficulty with moving
  • headache, severe and throbbing
  • joint or back pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • chest pressure or squeezing pain in chest
  • excessive sweating
  • feeling of heaviness, pain, warmth, and/or swelling in a leg or in the pelvis
  • sudden tingling or coldness in an arm or leg
  • sudden slow or difficult speech
  • sudden drowsiness or need to sleep
  • fast breathing
  • sharp pain when taking a deep breath
  • fast or slow heartbeat
  • coughing up blood
  • rust colored urine
  • decreased amount of urine

Rare

  • Anxiety
  • change in vision
  • seizures
  • abnormal or fast heart rate
  • tremors
  • weight loss
  • chest pain or tightness
  • confusion
  • cough
  • Agitation
  • arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • convulsions
  • extra heartbeats
  • fainting
  • hallucinations
  • headache
  • irritability
  • lightheadedness
  • mood or mental changes
  • muscle pain or cramps

Drug Interactions of Azithromycin

Azithromycin may interact with the following drugs, supplements, & may change the efficacy of drugs

  • antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • carvedilol
  • cyclosporine
  • dexamethasone
  • domperidone
  • estrogens (e.g., conjugated estrogen, estradiol, Ethinyl estradiol)
  • famotidine
  • “gliptin” diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)
  • hydrocortisone
  • loperamide
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • methotrexate
  • metronidazole
  • mirabegron
  • nadolol
  • protein kinase inhibitors (e.g., crizotinib, dasatinib, imatinib, nilotinib, sunitinib)
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • ranitidine
  • risperidone
  • salmeterol
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
  • sotalol
  • “statin” anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • trimethoprim
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • vardenafil
  • warfarin

Pregnancy Catagory

FDA Pregnancy Category – B

Pregnancy

  • There are no adequate data on the use of azithromycin in pregnant women. In reproduction toxicity studies in animals, azithromycin was shown to pass the placenta, but no teratogenic effects were observed. The safety of azithromycin has not been confirmed with regard to the use of the active substance during pregnancy. Therefore azithromycin should only be used during pregnancy if the benefit outweighs the risk.

Lactation

  • Azithromycin has been reported to be secreted into human breast milk, but there are no adequate and well-controlled clinical studies in nursing women that have characterized the pharmacokinetics of azithromycin excretion into human breast milk. In infertility studies conducted on the rat, reduced pregnancy rates were noted following administration of azithromycin. The relevance of this finding to humans is unknown.

FAQ

What is azithromycin used for?

  • Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs.

What kind of STD does azithromycin treat?

  • Azithromycin is the recommended treatment for chlamydia, nongonococcal urethritis, and cervicitis. It is also used in the recommended dual therapy for gonorrhea. Alternative regimens for chlamydia, nongonococcal urethritis, and cervicitis are outlined in the 2021 STI Treatment Guidelines.

Is azithromycin a strong antibiotic?

  • Also referred to as “Z-Paks,” Z-Packs are easy to use, generally affordable, and highly effective. Azithromycin is quickly absorbed when you take it by mouth, easily entering your body tissues so it can fight the bacteria causing your infection and stay active for a long time.

What are the possible side effects of azithromycin?

  • Stomach upset, diarrhea/loose stools, nausea, vomiting, or abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

Can azithromycin 500 mg be taken twice a day?

  • For treatment of infections: Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days.

What is azithromycin for Covid?

  • the antiviral and anti-inflammatory properties of azithromycin are suited to patients with early-stage COVID-19.

Does azithromycin 500mg cure STD?

  • A single dose of azithromycin 1 gram orally will cure genital chlamydia according to the CDC Guidelines for Sexually Transmitted Diseases, released in 2015, but still considered current. This is usually taken as four 250mg or two 500mg tablets of azithromycin in a single dose.

Can azithromycin alone treat STDs?

  • Background and objectives: Azithromycin is a new, long-acting azalide antibiotic that is active against Neisseria gonorrhoeae. A single oral dose of 1.0 g is effective against uncomplicated genital infection with Chlamydia trachomatis.

Are 3 days of azithromycin enough?

  • It is concluded that a 3-day regimen of azithromycin prescribed as tablets is as clinically and microbiologically effective as a 10-day regimen of co-amoxiclav in the treatment of acute lower respiratory tract infections.

What is the best way to take azithromycin?

  • You’ll usually take azithromycin once a day. Try to take your medicine at the same time each day. Swallow tablets and capsules whole with a drink of water. If you are taking azithromycin capsules, take them at least 1 hour before food or 2 hours after eating.

Which is better amoxicillin or azithromycin?

  • In adults with acute sinusitis, a 3-day course of azithromycin was as effective and well-tolerated as a 10-day course of amoxicillin/clavulanic acid. A significantly simpler dosage regimen and faster clinical effect were the advantages of azithromycin.

What are the worst side effects of azithromycin?

  • This medicine may increase the risk of serious heart or blood vessel problems. Call your doctor right away if you have blurred vision, chest pain, confusion, lightheadedness, dizziness, fainting, fast or irregular heartbeat, trouble breathing, or unusual tiredness or weakness.

Does azithromycin weaken the immune system?

  • Although azithromycin inhibits a variety of pro-inflammatory pathways, it does not result in full immune suppression as is induced by glucocorticoids and other immunosuppressive therapies.

Can azithromycin raise blood pressure?

  • Treatment with erythromycin was found to increase the risk of low blood pressure almost 6-fold, while clarithromycin increased the risk almost 4-fold. In contrast, azithromycin did not increase the risk of hypotension.

When should I take azithromycin 500mg?

  • Azithral 500 Tablet is taken orally, preferably one hour before or 2 hours after a meal. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better.

Is azithromycin good for cough and cold?

  • Azithromycin will only help infections caused by certain bacteria and will not work for the common cold, flu, or other viral infections.

Is azithromycin good for sore throat?

  • Azithromycin is an antibiotic that can treat strep throat, though it’s not a common choice for this infection.

Is azithromycin good for pneumonia?

  • Azithromycin is equally effective as a treatment of atypical pneumonia in adult patients if given for 3 or 5 days at the same total dose.

Is azithromycin used for pneumonia?

  • Azithromycin is used to treat certain bacterial infections (including sinusitis, and pneumonia). It is a macrolide-type antibiotic. It works by stopping the growth of bacteria. This medication will not work for viral infections (such as common cold, and flu).

How many azithromycins do I take for STDs?

  • Most people will get four pills: If this is what you have, you should take all four pills at the same time, with water. You need to take all four of the pills to cure the infection. Often, azithromycin pills contain 250 mg of the medicine (4 pills = 1000 mg total).

How effective is azithromycin?

  • Studies suggest that a one-gram dosage has 97% efficacy. That means that for every 100 people who take azithromycin to treat chlamydia, 97 will be cured and three will not be cured. In order to effectively treat chlamydial infections, azithromycin should be taken as prescribed until the dosage is completed.

Is it OK to take azithromycin for 5 days?

  • Use Azithromycin 5 Day Dose Pack 5 Day Dose Pack for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Azithromycin 5 Day Dose Pack will not treat a viral infection such as the flu or a common cold.

Can I stop taking azithromycin after 1 day?

Take as directed
  • Azithromycin is typically used for short-term treatment. It comes with risks if you don’t take it as prescribed. If you stop taking the drug or don’t take it at all: Your infection may not improve, or it may get worse.

How long should azithromycin take to work?

  • It takes 7 days for the medicine to work in your body and cure Chlamydia infection. If you have sex without a condom during the 7 days after taking the medicine, you could still pass the infection to your sex partners, even if you have no symptoms.

What should I avoid while taking azithromycin?

  • Do not take aluminum or magnesium-containing antacids two hours before or two hours after you take azithromycin because antacids can make azithromycin less effective. Discontinue azithromycin immediately and seek urgent medical advice if any sign of an allergic reaction (such as a rash or difficulty breathing) occurs.

Should I take azithromycin for 3 days or 5 days?

  • The overall clinical cure rate was 95.7% and 96.1%, and the bacteriological eradication rate 90.1% and 94.2% in the 3-day and 5-day groups, respectively. Side effects, mostly mild gastrointestinal disturbances, were observed in 5.3% of children from the 3-day, and 6.7% from the 5-day group.

What antibiotic is closest to azithromycin?

  • Cephalexin.
  • Clindamycin.
  • Keflex.
  • Amoxicillin.
  • Augmentin.
  • Amoxil.

Does azithromycin make you cough up mucus?

  • 250mg capsules (6), 2 to begin then 1 per day, 1 hour before, or 2hours after eating. Lots of coughing up phlegm but clears the chest so can breath properly.

Who shouldn’t take azithromycin?

Who should not take AZITHROMYCIN?
  • diarrhea from infection with Clostridium difficile bacteria.
  • low amount of magnesium in the blood.
  • low amount of potassium in the blood.
  • myasthenia gravis, a skeletal muscle disorder.
  • hearing loss.
  • torsades de pointes, a type of abnormal heart rhythm.
  • slow heartbeat.

Is azithromycin 500 mg used for COVID-19?

  • Azithromycin 500 mg is commonly used in primary care for bacterial respiratory infections and is similar to the dose used in early studies for COVID-19.

Is azithromycin good for viral fever?

  • Azithromycin (AZM) is a synthetic macrolide antibiotic effective against a broad range of bacterial and mycobacterial infections. Due to an additional range of anti-viral and anti-inflammatory properties, it has been given to patients with the coronaviruses SARS-CoV or MERS-CoV.

What are the common side effects of azithromycin?

  • Stomach upset, diarrhea/loose stools, nausea, vomiting, or abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

Can azithromycin cause fever?

  • Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Which is better amoxicillin or azithromycin?

  • In adults with acute sinusitis, a 3-day course of azithromycin was as effective and well-tolerated as a 10-day course of amoxicillin/clavulanic acid. A significantly simpler dosage regimen and faster clinical effect were the advantages of azithromycin.

Can azithromycin treat bronchitis?

  • Zithromax (azithromycin), also known as Z-Pak, is an antibiotic used to treat bacterial infections by inhibiting the growth of bacteria in the body. A Z-Pak is typically taken over a five-day course to treat infections such as bronchitis, pneumonia, and infections of the ears, lungs and other organs.

Will azithromycin treat gonorrhea?

  • Adults with gonorrhea are treated with antibiotics. Due to emerging strains of drug-resistant Neisseria gonorrhoeae, the Centers for Disease Control and Prevention recommends that uncomplicated gonorrhea be treated with the antibiotic ceftriaxone — given as an injection — with oral azithromycin (Zithromax).

Is 3 days of azithromycin enough?

  • It is concluded that a 3-day regimen of azithromycin prescribed as tablets is as clinically and microbiologically effective as a 10-day regimen of co-amoxiclav in the treatment of acute lower respiratory tract infections.

How long should I take azithromycin for COVID-19?

  • We would like to know if the azithromycin regimen (500 mg once daily for 14 days) was based on any pre-established guidelines or recommendations. We consider that it is unreasonable to expose someone with 14 days of symptoms, who might already be near resolution, to a further 14 days of treatment with azithromycin.

Why is azithromycin only given for 3 days?

  • Co-amoxiclav is frequently given as treatment for LRTI in children. Compliance is often a problem as it is usually given three times a day for 10 days. Because of the pharmacokinetic profile, it is possible to administer azithromycin in a once-daily dose for 3 days.

Can azithromycin be taken after food?

  • If you are taking azithromycin capsules, take them at least 1 hour before food or 2 hours after eating. If you have tablets or liquid, you can take them with or without food.

When should I take azithromycin 500mg?

  • Azithral 500 Tablet is taken orally, preferably one hour before or 2 hours after a meal. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better.

Can I take azithromycin on an empty stomach?

  • If you are taking azithromycin capsules, you should take your doses when your stomach is empty. This means taking them one hour before any food or waiting until two hours afterward. If you are taking tablets or liquid medicine, these can be taken either before or after food.

Can I take azithromycin 500mg twice a day?

  • For treatment of infections: Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days.

How effective is azithromycin?

  • Studies suggest that a one-gram dosage has 97% efficacy. That means that for every 100 people who take azithromycin to treat chlamydia, 97 will be cured and three will not be cured. In order to effectively treat chlamydial infections, azithromycin should be taken as prescribed and until the dosage is completed.

Can I drink coffee while taking azithromycin?

  • It is a substance that is easily broken down by the body. When taking these antibiotics, take them in conjunction with coffee, which might cause additional side effects including jitteriness, headaches, increased heart rates, and some side effects like insomnia.
Interactions between your drugs
  • No interactions were found between azithromycin and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Is it OK to drink milk while taking azithromycin?

  • It’s recommended that dairy products such as cheese, milk, butter, and yogurt should not be consumed until 3 hours after a dose of antibiotics is taken. Likewise, juices or supplements containing calcium may also reduce effectiveness.

Can azithromycin 500 mg be taken for 5 days?

  • Use Azithromycin 5 Day Dose Pack 5 Day Dose Pack for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Azithromycin 5 Day Dose Pack will not treat a viral infection such as the flu or a common cold.

Why is azithromycin given for Covid?

  • Azithromycin use was associated with a reduction in mortality and ventilation days in other viral infections. These properties could be beneficial throughout the COVID-19.

Does azithromycin increase blood pressure?

  • Treatment with erythromycin was found to increase the risk of low blood pressure almost 6-fold, while clarithromycin increased the risk almost 4-fold. In contrast, azithromycin did not increase the risk of hypotension.
Interactions between your drugs
  • No interactions were found between azithromycin and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Who should not take azithromycin?

Who should not take AZITHROMYCIN?
  • diarrhea from infection with Clostridium difficile bacteria.
  • low amount of magnesium in the blood.
  • low amount of potassium in the blood.
  • myasthenia gravis, is a skeletal muscle disorder.
  • hearing loss.
  • torsades de pointes, a type of abnormal heart rhythm.
  • slow heartbeat.

Does azithromycin weaken the immune system?

  • Although azithromycin inhibits a variety of pro-inflammatory pathways, it does not result in full immune suppression as is induced by glucocorticoids and other immunosuppressive therapies.

Is azithromycin a strong antibiotic?

  • Also referred to as “Z-Paks,” Z-Packs are easy to use, generally affordable, and highly effective. Azithromycin is quickly absorbed when you take it by mouth, easily entering your body tissues so it can fight the bacteria causing your infection and stay active for a long time.

What are the worst side effects of azithromycin?

  • This medicine may increase the risk of serious heart or blood vessel problems. Call your doctor right away if you have blurred vision, chest pain, confusion, lightheadedness, dizziness, fainting, fast or irregular heartbeat, trouble breathing, or unusual tiredness or weakness.

What are the serious side effects of azithromycin?

  • The drug’s active ingredient, azithromycin, can cause rare but serious side effects such as severe or life-threatening allergic reactions, irregular heartbeats, Clostridium difficile-associated diarrhea, and liver damage. More common side effects include nausea or vomiting, diarrhea, and abdominal pain.

Which is better azithromycin or amoxicillin?

  • In adults with acute sinusitis, a 3-day course of azithromycin was as effective and well-tolerated as a 10-day course of amoxicillin/clavulanic acid. A significantly simpler dosage regimen and faster clinical effect were the advantages of azithromycin.

Why azithromycin is given once daily?

  • In this study, we demonstrate that azithromycin administered over a shorter (1-day) dosing period provides superior efficacy when compared with 2 or 3-day regimens. Most significantly, a 1-day regimen results in more rapid eradication of H.

What is the course of azithromycin tablets?

  • Azithromycin is the first member of the azalide class of antimicrobial agents. It is now widely available for the treatment of infections in adults and children. We have shown that a 3 day course of azithromycin is efficacious for acute exacerbation of chronic bronchitis and lower respiratory bacterial infections.

Can I take azithromycin for 7 days?

  • 500 mg IV once daily until symptoms abate, followed by oral stepdown therapy for a total treatment duration of 7 to 10 days. 10 mg/kg/dose (Max: 500 mg/dose) IV once daily until symptoms abate, followed by oral stepdown therapy for a total treatment duration of 7 to 10 days.

What should I eat after taking azithromycin?

  • If you are taking azithromycin capsules, take them at least 1 hour before food or 2 hours after eating. If you have tablets or liquid, you can take them with or without food. The liquid can have a bitter aftertaste, so it can be a good idea to offer children a drink of fruit juice afterward.

When should I take azithromycin 500mg?

  • Azithral 500 Tablet is taken orally, preferably one hour before or 2 hours after a meal. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better.

Does azithromycin affect the kidneys?

  • Azithromycin metabolism is not affected by kidney function.

Which is better Amoxiclav or azithromycin?

  • Azithromycin produced a significantly higher cure rate (70.6% versus 61.1%) than co-amoxiclav (P = 0.011) and there were fewer failures (7.8% versus 13.6%) and relapses in the azithromycin-treated group, giving a higher overall response rate for azithromycin (89.7% versus 80.2%, P = 0.0003).

Is it OK to drink milk while taking azithromycin?

  • It’s recommended that dairy products such as cheese, milk, butter, and yogurt should not be consumed until 3 hours after a dose of antibiotics is taken. Likewise, juices or supplements containing calcium may also reduce effectiveness.

Can I take azithromycin on an empty stomach?

  • If you are taking azithromycin capsules, you should take your doses when your stomach is empty. This means taking them one hour before any food or waiting until two hours afterward. If you are taking tablets or liquid medicine, these can be taken either before or after food.

Should I take azithromycin for Covid?

  • Antibiotics do not kill the SARS-CoV-2 virus, the virus causes COVID-19. Antibiotics are used to treat bacterial infections. Azithromycin and other antibiotics are not recommended to treat COVID-19 unless they are being prescribed an antibiotic for a bacterial infection the patient currently has as well as COVID-19.

 

  1. ChemIDplus

    https://chem.nlm.nih.gov/chemidplus/sid/0117772700

    https://chem.nlm.nih.gov/chemidplus/sid/0083905015

    https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp

  2. DrugBank

    http://www.drugbank.ca/drugs/DB00207
    http://www.drugbank.ca/drugs/DB00207#enzymes
    http://www.drugbank.ca/drugs/DB00207#targets
    http://www.drugbank.ca/drugs/DB00207#transporters

    https://www.drugs.com/azithromycin.html

  3. EPA DSStox

    https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID8030760

  4. European Chemicals Agency – ECHA

    https://www.echa.europa.eu

    https://www.echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-database/-/discli/details/173806

    https://www.webmd.com/drugs/2/drug-1527-6223/azithromycin-oral/azithromycin-powder-packet-oral/details/list-contraindications

    https://www.echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-database/-/discli/details/100852

  5. Human Metabolome Database (HMDB)

    http://www.hmdb.ca/metabolites/HMDB0014352

  6. ClinicalTrials.gov

    https://clinicaltrials.gov/

  7. DailyMed

    https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=AZITHROMYCIN+DIHYDRATE

    https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=AZITHROMYCIN

  8. FDA Pharm Classes

    https://www.accessdata.fda.gov/spl/data/9486dbab-89e4-48e5-855a-df81c945a68c/9486dbab-89e4-48e5-855a-df81c945a68c.xml

    https://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm

  9. LiverTox

    https://livertox.nlm.nih.gov/Azithromycin.htm

  10. NCIT

    https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C28844

  11. FDA/SPL Indexing Data

    https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/

  12. HSDB

    https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+@rel+83905-01-5

  13. FDA Orange Book

    https://www.fda.gov/Drugs/InformationOnDrugs/ucm129662.htm

  14. MassBank of North America (MoNA)

    http://mona.fiehnlab.ucdavis.edu/spectra/browse?inchikey=MQTOSJVFKKJCRP-BICOPXKESA-N

  15. NIST

    http://www.nist.gov/srd/nist1a.cfm

  16. PubMed Health

    http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0009183/

    http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0009182/

    http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0009184/

    http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0000192/

  17. Springer Nature Read more …
  18. WHO ATC

    https://www.whocc.no/atc/

    https://www.whocc.no/atc_ddd_index/

  19. Wikipedia

    https://www.wikidata.org/wiki/Q27116139

    https://www.wikidata.org/wiki/Q27281692

    https://en.wikipedia.org/wiki/Azithromycin

    https://pubchem.ncbi.nlm.nih.gov

  20. MeSH

    https://www.ncbi.nlm.nih.gov/mesh/68017963

    http://www.nlm.nih.gov/mesh/meshhome.html

    https://www.ncbi.nlm.nih.gov/mesh/68000900

  21. ChEBI

    http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology

  22. WIPO

    http://www.wipo.int/classifications/ipc/

  23. ChEMBL

    https://www.ebi.ac.uk/chembl/target/browser

  24. IUPHAR/BPS Guide to PHARMACOLOGY

    http://www.guidetopharmacology.org/

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