Peperomia Pellucida – Nutritional Value, Health Benefits
Peperomia pellucida (also known by common names pepper elder, shining bush plant, and man to man) is an annual, shallow-rooted herb, usually growing to a height of about 15 to 45 cm (6 to 18 inches), it is characterized by succulent stems, shiny, heart-shaped, fleshy leaves and tiny, dot-like seeds attached to several fruiting spikes. It has a mustard-like odor when crushed. The family Piperaceae comprises about a dozen genera and around 3000 species. The genus Peperomia represents nearly half of the Piperaceae with the genus Piper making the rest.
Pansit-pansitan, scientifically known as Pepromia pellucida, is a medicinal plant valued for its anti-gout properties which helps lower uric acid in the blood. It was one of the ten clinically tested medicinal plants endorsed by the Department of Health. It was reported that pansit-pansitan contained a high amount of toxic metal like lead (Pb) and cadmium (Cd) surpassing the limits allowed by the WHO [World Health Organization]. To regulate the uptake of the nutrient elements in pansit-pansitan, the use of hydroponic culture through non-aerated Hoagland’s solution was studied. Metal analysis showed that pansit-pansitan grown and collected from various locations showed that none of the plant samples passed the WHO standard of Cd and Pb. On the other hand, plants grown in the UPLB greenhouse and genebank had Cd and Pb within the WHO limit. Pansit-pansitan plants grown hydroponically had lower Pb and Cd content than those grown in soil. Results of further studies indicated that a decrease in the strength and yield of the Hoagland’s solution decreased the shoot length, number of branches, fresh weight, and dry weight of the plant. Root length was not affected. Decreasing the volume of full-strength Hoagland’s solution reduced the values of all the above parameters. This means that one must replenish the medium with a fresh solution to encourage and maintain the normal growth of pansit-pansitan. A single pansit-pansitan plant can be maintained in a 500 ml full-strength Hoa
Scientific Name: Peperomia pellucida Linn
Also knows as:
It is known as pepper elder, silverbush, rat-ear, man-to-man, clearweed (North America); prenetaria (Puerto Rico); konsaka wiwiri (Suriname); coraçãozinho or “little heart” (Brazil); lingua de sapo, herva-de-vidro, herva-de-jaboti or herva-de-jabuti (South America), ewe rinrin (Yoruba Nigeria), corazón de hombre (Cuba).[rx] In Oceania, it is called retail (Belauan); podpod-lahe or potpopot (Chamorro). In the different dialects of the Philippines, it is called pansit-pansitan or ulasimang-bato (Tagalog), olasiman ihalas (Bisaya), sinaw-sinaw or tangon-tangon (Bikol), lin-linnaaw (Ilocano) and “clavo-clavo” (Chavacano). In other parts of Asia, it is known as càng cua (Vietnam);nathamee koon နတ်သမီးကွမ်း (Burmese); sagar bataing သဂါဗတာင် (Mon); pak krasang ผักกระสัง (Thailand); “krasang teap” ក្រសាំងទាប (Cambodia); suna kosho (Japan); rangu-rangu, ketumpangan or tumpang angin (Bahasa/Malay); sasaladahan (Sundanese); rinrin (Nigeria), “shining bush” (Trinidad and Tobago), and mashithanduമഷിത്തണ്ട്, വെള്ളത്തണ്ട് and വെള്ളപ്പച്ചില (Malayalam); diya thippili දිය තිප්පිලි (Sinhalese). In west Bengal, India the plant is locally known as “Luchi pata”. In Guyana the plant is also known as “Soldier Parsley.” In Commonwealth of Dominica it is known as zèb kouwès.[rx] Pansit-pansitan, Ulasimang bato, Clear weed, Shiny bush, Silverbush, Cao hu jiao
Pansit-pansitan (Peperomia pellucida Linn) is a common fleshy shallow-rooted herb that grows to about 15 to 45 cm in height in damp and lightly shaded areas. Pansit-Pakistan has been used as a food item as well as a medicinal herb for its analgesic, anti-arthritic, diuretic activity. The entire plant is edible both cooked or raw.
Pansit-partisan plants can grow wild but also grown as ornamental foliage. Pansit-Pakistan is characterized by its shiny heart-shaped leaves about 4 cm in length, growing from an erect translucent green stalk. Pansit-Pakistan has tiny dot-like flowers that grow from erect and slender green spikes that turn brown when matured. The fruits are also very small, round to oblong, ridged, first green later black. Tiny seeds drop off that grow easily in groups.
Pansit-pansitan Traditional Health Benefits
Properties
• Considered anti-inflammatory, antibacterial, refrigerant, analgesic, antifungal, anticancer.
• Studies have shown analgesic, anti-inflammatory, CNS depressant, antioxidant, antihyperuricemic, hypoglycemic, antihypertensive, antibacterial, antiarthritic, anticancer, antiedematogenic, anti-amoebic, gastroprotective, and hemostatic properties.
Parts utilized
Leaves and stems.
Uses
Edibility
– Leaves and stems may be eaten as vegetable.
– In salads, the fresh plant has the crispness of carrot sticks and celery.
Folkloric
– Infusion and decoction of leaves and stems are used for gout and arthritis.
– Decoction of leaves used for urinary tract infections.
– Externally, as a facial rinse for complexion problems.
– In Ayurveda, used to pacify vitiated cough, pitta, constipation, kidney diseases, urinary retention, dysuria, urinary tract infection, emaciation, edema and general weakness. (15)
– Pounded whole plant used as warm poultice for boils, pustules and pimples.
– In Jamaica and the Caribbean used for colds and as a diuretic for kidney problems.
– In South America, solution of fresh juice of stem and leaves used for eye inflammation. Infusion and decoction of leaves and stems used for gout and arthritis. (15)
– In Brazil, used for abscesses and conjunctivitis.
– In Bolivia, decoction of roots used for fever; aerial parts for wounds.
– In Nigeria used for hypertension.
– In Bangladesh, leaves used in the treatment of excited mental disorders.
– In Africa, used for convulsions and tumors.
– Used for headaches, rheumatic pains, impotence.
– In Cameroon used for fracture healing.
– In Brazil, used to lower cholesterol; for the treatment of abscesses, furuncles, and conjunctivitis
New uses
– Belongs to the “preferred list” of Philippine medicinal plants, being studied for its use in the treatment of arthritis and gout.
For arthritis: Leaves and stems of the fresh plant may be eaten as a salad. Or, as an infusion, put a 20-cm plant in 2 glasses of boiling water; and 1/2 cup of this infusion is taken morning and evening.
Studies
• Analgesic / Antiinflammatory / Aerial Parts: Extract study of aerial parts of PP tested in rats and mice exhibited anti-inflammatory and analgesic activities. The anti-inflammatory activity was attributed to interference with prostaglandin synthesis. Results also showed low toxicity. (1) Study of methanol extract of P. pellucida aerial parts showed significant analgesic activity on acetic acid-induced writhing in mice. (43)
• CNS Depressant Activity: Study of peperomia leaf extract showed dose-dependent depressant effects probably due to psychoactive substances that are CNS depressants. (2)
• Antipyretic: Study of petroleum ether and ethyl acetate soluble fractions of an ethanol leaf extract of Peperomia pellucida on rabbits showed antipyretic effects comparable to a standard aspirin. (3) In a study that evaluated the effect of Peperomia pellucida crude leaf extract on boiled milk-induced fever in male white mice, results showed no antipyretic effect.
• Antibacterial: Study of methanolic extract of PP exhibited a very good level of broad-spectrum antibacterial activity. (4) A methanol crude extract showed growth inhibition for E. coli at 1% and 10% concentration, but no inhibition of growth of S. aureus. (24)
• Phenological Antiedematogenic: P pellucida has a phenological cycle of about 100 days. The aqueous extract is used as antiedematogenic during pheophases 1 and 2 of winter and spring.(5)
• Anti-Cancer: Study isolated five new compounds, including two secolignans, two tetrahydrofuran lignans, one highly methoxylated dihydronaphthalenone with known peperomins A, B, C and E. Compound 1 and peperomin E showed growth inhibitory effects on three cancer cell lines.(6)
• Toxicity Study: Study evaluated the potential systemic toxicity of acute oral use of P. pellucida freeze-dried aqueous extract powder in mice. In excessive amounts, P. pellucida showed a dose-dependent increase in adverse effects in the major systems of the body. The moderate slope of the dose-response line was suggestive of a moderately wide margin of safety of the plant.(7)
• Analgesic / Anti-Arthritic Study: Study showed both twice daily P. pellucida decoction and ibuprofen treatment significantly lowered the mean scores on pain, stiffness and disability on the WOMAC arthritis index on patients with knee joint rheumatism. (8)
• Xanthone Glycoside / Antibacterial: Study isolated patuloside A, a xanthone glycoside from P. pellucida. The compound showed significant antibacterial activity against four Gram-positive bacteria (B subtilis, B megaterium, S aureus, Strep ß-hemolyticus) and six Gram-negative bacteria (E coli, S dysenteriae, S sonnei, S flexneri, P aeruginosa and S typhi.) (9)
• Antihyperuricemic: A randomized controlled study of the effect of freeze-dried aqueous extract powder of P. pellucida in male adult Sprague Dawley rats showed a mean % decrease from hyperuricemic level of 44.1% compared to allopurinol’s 64.0%. Results indicate P. pellucida may be used as an alternative medication for hyperuricemia. (11)
• Anti-Inflammatory / Antioxidant: A petroleum ether extract significantly reduced carrageenan-induced hind paw edema. The methanol extract showed the strongest free radical scavenging activity. Results suggest the plant is a good natural source for anti-inflammatory and antioxidant therapy. (12)
• Phytochemical / Antimicrobial / Toxicological Evaluation: Photochemical studies yielded alkaloids, tannins and flavonoids. Extracts inhibited growth of Pseudomonas aeruginosa, K. pneumonia, and B. subtilis, while only the methanol extract inhibited Staphylococcus aureus. Oral doses as high as 5g/kg did not cause death or toxicological symptoms in mice. Histopathological effects of an aqueous methanol extract on the liver, spleen kidney and heart of rats showed mild to moderate congestions and infiltrations of chronic inflammatory cells.(16)
• Mineral Composition / Nutritional Attributes: Study evaluated the proximate and mineral composition and nutritional attributes of P. pellucida. Results showed it to be rich in crude protein, carbohydrate, and total ash contents. The ash content suggest a high-value for potassium, calcium, and iron as main elements. Results suggest P. pellucida can serve as a good source of protein, energy, and micronutrients.(17)
• Hypotensive Effect / Cytochrome P450 Effect: Study evaluated P. pellucida for its use as an antihypertensive remedy and its impact on cytochrome P450 (CYP) enzyme activity. Results showed a dose-dependent hypotensive, bradycardic, and vasorelaxant effects probably mediated through nitric oxide-dependent mechanisms. An aqueous extract showed poor in vitro inhibition on CYP3A4 enzyme making it unlikely to cause clinically significant pharmacokinetic drug interactions via the enzyme inhibition.(19)
• Anticancer / Antimicrobial / Antioxidant / Leaves: Study showed P. pellucida leaf extract possessed anticancer activities. The plant extract was found to inhibit growth of various bacterial pathogens and inhibit 30% of DPPH, free radical. Phytol was the major compound in the plant extract, followed by 2-naphthalenol, hexadecanoic acid, methyl ester and 9,12-octadecadienoic acid, and (Z,Z)-methyl ester. Results indicate the leaf possessed vast potential as a medicinal drug especially in breast cancer treatment. (21)
• Fracture Healing by Anabolic Effect on Osteoblasts: Study evaluated an ethanol extract of P. pellucida on bone regeneration following bone and marrow injury in rats. Results showed the EE dose-dependently induced bone regeneration at the fracture site, with significantly increased mineral deposition compared to controls. Findings suggest acceleration of fracture repair via stimulatory effect on osteoblast differentiation and mineralization. (22)
• Hemostatic Effects: Study of P. pellucida plant crude extract showed coagulation properties that can induce blood clotting and augment thrombocyte production. (23)
• Antibacterial / Leaves: An ethanol extract of leaves yielded fifteen compounds and showed marked antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Escherichia coli, Salmonella typhi and Proteus mirabilis. The synergistic effect of the compounds might have caused the high antibacterial activity. (see constituents above) (25)
• Antidiabetic / Antioxidant / Hypolipidemic: Study investigated the antidiabetic and antioxidant properties of Peperomia pellucida in alloxan induced diabetic male albino rats. Diabetic rats on diets supplemented with P. pellucida showed reduction in blood glucose, significant reduced serum cholesterol, triglycerides and LDL cholesterol, and significantly reduced lipid peroxidation. (26)
• Antiamoebic: Study evaluated P. pellucida for antiamoebic activity. A methanol fraction of dried plant caused morphological and structural changes in Acanthamoeba cysts. (28)
• Antihypertensive: Study evaluated the anti-hypertensive effects of Peperomia pellucida extract on arterial blood pressure in male, normotensive rats. Intravenous administration of the extract produced marked fall in mean arterial blood pressure and heart rate. (29)
• Hypoglycemic / Analgesic / Anti-Inflammatory: Study of an ethyl acetate extract in alloxan induced diabetic mice showed significant hypoglycemic effect. Results also showed significant analgesic activity in the acetic acid induced writhing model, which may be attributed to the presence of flavonoid, steroid, alkaloid, tannin and saponin noted on phytochemical screening. (30)
• Gastroprotective / Anti-Ulcer: Study evaluated the anti-ulcerogenic activity of aerial parts of P. pellucida in necrotizing agent and indomethacin induced models in rats. Results showed significant protection in various experimental models with significant pretreatment inhibition of gastric mucosal damage. (31)
• Anti-Hyperuricemic Effect on Potassium Oxonate-Induced Hyperuricemia: Study showed an anti-hyperuricemic effect of Peperomia pellucida extract in potassium oxonnate induced hyperuricemia in white male rats. (35)
• Antimicrobial / Leaves: Study evaluated leaf extracts for antimicrobial activity and phytochemical properties. Extracts yielded flavonoids and saponins while alkaloids, steroids, and tannins were absent in the methanol and EA extracts. Extracts showed antimicrobial activity against P. aeruginosa, S. typhii, and S. dysenteriae, comparable to standard antibiotic streptomycin. (36)
• Acceleration of Fracture Healing / Whole Plant: Study evaluated the effects of aqueous whole plant extract of P. pellucida on fracture healing in female Wistar rats. The extract accelerated bone healing partly due to the mineral content. There was a significant increase in amounts of calcium, phosphorus, and AP. There was a dose dependent effect on callus formation. Results suggest osteoblastic effects responsible for enhancement of bone repair process. (37)
• Capacity for Bioaccumulation of Lead: Some plants species absorb large quantities of heavy metals like lead which can accumulate in the body and lead to heavy metal poisoning. A greenhouse study showed showed application of 100-400 ppm Pb had no significant effect on shoot and root growth. Results showed P. pellucida can tolerate Pb levels as high as 400 ppm without affecting its growth. (38)
• Radical Scavenging / Antibacterial / Leaves and Stem Essential Oils: Study evaluated leaves and stem essential oils of P. pellucida for in vitro antibacterial and radical scavenging activities. The EOs showed strong antibacterial activities against bacterial strains viz., E. coli, Enterobacter cloacae, Myobacterium smegmatis, Listeria ivanovii, S. aureus, Streptococcus uberis and Vibro parahaemolyticus with MIC range between 0.95 and 0.20 mg/ml for both EOs. Leaf EO showed more radical scavenging (1.67 mg/mL) than the stem EO (2.83 mg/mL. (39)
• Protective Effects on Pancreas / Potential Antidiabetic Treatment: Study evaluated the crude methanolic extract of P. pellucida for antihyperglycemic property and its effect on pancreatic histology in high fat-diet/STZ-induuced diabetic mice. While a two-week administration showed no signficant effect on blood glucose levels, the extract prevented necrosis, apoptosis, and inflammation of the Islets of Langerhans. Results suggest a protective effect on the pancreas and a potential alternative to metformin in the treatment of T2DM. (40)
• Dillapiole / Gastroprotective / Ethanol-Induced Lesions: Study of a hexane and dichlormethane extract of P. pellucida yielded dillapiole as the most active compound. The compound was evaluated for gastroprotective effect using an ethanol-induced gastric ulcer rat model. Dillapiole showed gastroprotection unrelated to endogenous NO, prostaglandins or sulfhydryl groups. (41)
• Natural Radioactivity of P. pellucida Used as Medicinal Herb: Study evaluated the concentration of naturally occurring radionuclides U, U, Th, Th, Ra, Ra and Pb in a sample of Peperomia pellucida and in the surrounding soil. An emerging concern in many developing countries is industrial pollution that may threaten the health of local government by contamination of vegetation with heavy metals, pesticides, or radioactivity. In this study, the level of radionuclides showed much higher concentrations than that present in day-to-day diet. In the context of plant extraction for phytotherapies and the consumption of herbs by the population, the study of radionuclide concentration in medicinal plants has great significance.
• Cytotoxicity: Study evaluated various extracts of P. pellucida for phytochemical constituents and cytotoxicity potential by in vitro MTT assay using HEK 293 (human epithelial kidney) HeLa (human cervical cancer) and HepB2 (human hepatic carcinoma) cell lines. The methanol extract showed maximum phytochemicals and significant cytotoxic activity against the test cancer cell lines and showed less cytotoxicity against normal human kidney cells (HEK293) suggesting safety for normal cells.
• Antifungal / Leaves: Study of Peperomia pellucida leaf ethanol extract showed most effective antifungal activity against C. albicans colony growth inhibition at 70% concentration.
• Patuloside A / Xanthone Glycoside / Antimicrobial / Cytotoxicity: Study pf Peperomia pellucida isolated a xanthone glycoside, Patuloside A (3-β-D glucopyranosyloxy-1,5,6-trihydroxy-9H-xanthene-9-one). The compound showed significant antibacterial activity against four Gram-positive and six gram-negative bacteria and weak antifungal activity against A. flavus and C. Albicans. It showed cytotoxicity against brine shrimp nauplii with an IC50 of 18.24 µg/ml.
• Acaricidal / Essential Oils: Study evaluated leave and stem for essential oil by GC and GC-MS analysis. Sesquiterpenes were the most abundant class of compounds. The activity of the oil against Tetrnychus article showed the stem oil was fourfold more toxic than the leaf oil but 2.5-fold less activity than eugenol which was used as positive control. (see constituents above)
Pansit-pansitan is widely used as folkloric herbal medicine. Pansit-pansitan is known for the following health benefits:
- Eye inflammation,
- Sore throat,
- Diarrhea,
- Prostate problems,
- High blood pressure,
- Arthritis,
- Gout,
- Skin boils,
- Wounds,
- Burns,
- Skin inflammation,
- abscesses,
- pimples,
- Headache
- Fever,
- Abdominal pains ,
- Renal problems,
- Mental excitement disorder.
Scientific Studies: Peperomia pellucida (Pansit-pansitan) Herbal Medicine
Analgesic / Anti-inflammatory action of Pansit-pansitan
Pansit-pansitan has been traditionally used to treat fever, cough, common cold, headache, and arthritis. A study of aerial parts of peperomia extract in mice indicated that it exhibited anti-inflammatory and analgesic activities. The anti-inflammatory activity was attributed to interference with prostaglandin synthesis. In another study done on rabbits, pansit-pansitan extract exhibited an antipyretic activity which indicates that it is comparable to standard aspirin. (ref)
Anti-cancer Activity of Pansit-pansitan
A study has isolated compounds in P.Pellucida that have inhibitory actions against the growth of some cancer cells. This shows its potential as an anti-cancer supplement. (ref)
Antioxidant activity of Pansit-pansitan
In a study done on P.Pellucida extract, it has shown that it has a strong scavenging activity against free radicals suggesting that pansit-pansitan is a good natural anti-oxidant (ref)
Anti-bacterial activity of Pansit-pansitan
A study has isolated a compound called patuloside A, a xanthone glycoside from P. pellucida that is found to have broad spectrum antibacterial activity (ref)
Anti-arthritic Activity of Pansit-pansitan
A study has shown that extracts from pansit-pansitan combined with ibuprofen treatment have significantly improved the symptoms associated with arthritis. Particularly that of knee joint rheumatism.(ref)
Uric Acid Reduction in blood
In a controlled study involving rats, extracts from P. pellucida were administered and uric acid levels were monitored. The study have shown that rats that were subjected to pansit-pansitan extract indicated a 44% reduction of the uric acid level in blood while those that are given allopurinol drug have shown 66% reduction in uric acid level. These results show that pansit-pansitan may contain compounds that may be used as alternative to allopurinol to control uric acid levels in the blood. (ref)
The depressant activity of Pansit-pansitan
In a study done in Bangladesh, mice were given nikethamide to induce excitement. The mice were later administered with extracts from peperomia pellucida to determine their depressant activity. The results of the study suggest that pansit-pansitan extract has a dose-dependent depressant activity that is beneficial for the treatment of excessive mental excitement. disorder. (ref)
Pansit-pansitan Usage, Dosage
Where can I buy / get Pansit-pansitan?
Pepperomia Pellucida or pansit-pansitan grows wild in nooks and corners in damp lightly shaded areas. The whole plant can be harvested fresh, eaten raw as in salad ingredients or cooked with other vegetables and meat.
Pansit-pansitan tea can be prepared by collecting stems and leaves mixed with boiled water (see below) or formed into poultice to be applied topically over skin wounds and inflammation.
Pansit-pansitan Tea Preparation
- wash freshly gathered Pansit-pansitan plant parts
- chop then add in 4 cups of water for every 1 cup
- let it boil for 10 to 15 minutes with the pot cover removed.
- Let it steep then strain.
- Drink half a cup of Pansit-pansitan tea three times a day.
- Pansit-pansitan tea concoction can be stored in a suitable glass container for later consumption.
Dried leaves are more potent. Reduce the blend by half.
Pansit-pansitan Use, Warnings and Side Effects
Pepperomia Pellucida or pansit-pansitan intake and use have no reported side effects for most people. In a study done on pansit-pansitan extract overdose in mice, it was suggestive of a moderately wide margin of safety of the plant
Pregnancy and Breastfeeding. There are no sufficient studies made to determine the side effects of Peperomia Pellucida (Pansit-pansitan) taken in medicinal amounts to infants and babies. Stay on the safe side, avoid taking Pansit-pansitan in herbal medicine dosage when pregnant and while breastfeeding.
Allergies. In rare cases, the herb has caused allergic reactions as a side effect.
Pansit-pansitan salad
In some Southeast Asian countries, particularly in Vietnam, pansit-pansitan is prepared in a variety of ways. most notably as a vegetable side dish, a salad, and in soups. In the Philippines,
Here is a simple salad recipe on how I prepare pansit-pansitan at home:
Ingredients:
- A good bunch of pansit-pansitan (you can just pick the stems and leaves and leave the root in the soil)
- 3 medium ripe tomatoes
- 1 medium white onion (you may use 2 medium red onions if unavailable)
Dressing
- Juice from 5 pieces calamansi or half of medium-sized lemon
- 2 pieces chili, chopped
- 2 cloves garlic, grated
- Half a piece of ginger, grated
- Fish bagoong (Balayan or Pangasinan)
Procedure:
- Wash the pansit-pansitan at least twice in clean water and cut them into smaller pieces.
- Chop the tomatoes and the onions.
- For the sauce, combine the calamansi juice, grated garlic and ginger, chopped chili, and gradually add the bagoong until you get the desired flavor.
- Toss all the ingredients together until all the vegetables are coated with the dressing. You may serve this immediately or chill before serving it.
Recipe
If you want to print a copy of this pansit-pansitan salad recipe, you can do so using this recipe card:
Author: Ivan Jose
- A bunch of pansit-pansitan (leaves and stems)
- 3 medium ripe tomatoes
- 1 medium white onion or 3 medium red onions
- Juice from 5 pieces of calamansi
- 2 pieces chili
- 2 cloves garlic, grated
- half a piece of ginger, grated
- fish bagoong (Balayan or Pangasinan)
Instructions
- Wash the pansit-pansitan at least twice in clean water and cut them into smaller pieces.
- Chop the tomatoes and the onions.
- For the sauce, combine the calamansi juice, grated garlic and ginger, chopped chili, and gradually add the bagoong until you get the desired flavor.
- Toss all the ingredients together until all the vegetables are coated with the dressing. You may serve this immediately or chill it before serving.
- Serve during breakfast.
References

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