Granuloma Gravidarum - Rxharun

Granuloma Gravidarum

Granuloma gravidarum is a medical condition that is characterized by the development of granulomas, or clusters of immune cells, during pregnancy. This condition is considered to be relatively rare and usually occurs in the second or third trimester of pregnancy.

The exact cause of granuloma gravidarum is not fully understood, but it is thought to be related to the changes in the immune system that occur during pregnancy. Hormonal changes and an increase in the production of cytokines (proteins involved in inflammation) may also play a role in the development of this condition.


The exact cause of granuloma gravidarum is unknown, but several factors are believed to contribute to its development. These include:

  1. Hormonal changes: During pregnancy, hormonal changes can cause skin changes and an increased blood flow to the skin. This can lead to the formation of granulomas.
  2. Genetic predisposition: Some women may have a genetic predisposition to develop granuloma gravidarum.
  3. Immune system changes: The immune system changes that occur during pregnancy can make women more susceptible to skin conditions like granuloma gravidarum.
  4. Trauma: Trauma to the skin, such as rubbing or scratching, can cause granulomas to form.
  5. Infections: Certain infections, such as streptococcal infections, can trigger the development of granulomas.
  6. Skin conditions: Certain skin conditions, such as eczema or psoriasis, can also increase the risk of developing granuloma gravidarum.

It is important to note that granuloma gravidarum is a benign condition that does not pose any harm to the mother or the baby. However, if the granulomas become painful or infected, medical treatment may be necessary.


It is characterized by the formation of granulomas, which are small clusters of immune cells, in various parts of the body, including the skin, liver, and lymph nodes.

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The main symptoms of granuloma gravidarum include:

  1. Skin Lesions: The most common symptom of granuloma gravidarum is the appearance of skin lesions, which are raised, red, and sometimes itchy bumps. These lesions usually develop on the face, arms, and legs and can be painful.
  2. Abdominal Pain: Some women with granuloma gravidarum may experience abdominal pain and discomfort, especially if the granulomas are affecting the liver.
  3. Fatigue: This condition can cause fatigue, weakness, and decreased energy levels.
  4. Jaundice: If the granulomas are affecting the liver, jaundice may develop, causing yellowing of the skin and eyes.
  5. Weight Loss: Some women with granuloma gravidarum may experience weight loss, as the condition can cause a decrease in appetite and food intake.
  6. Fever: A fever may develop as a result of the body’s immune response to the granulomas.
  7. Swollen Lymph Nodes: Granulomas may also form in the lymph nodes, causing them to become swollen and tender.

It is important to seek medical attention if you are experiencing any of these symptoms during pregnancy, as granuloma gravidarum can cause complications for both the mother and the baby.


The main diagnosis tests for granuloma gravidarum include:

  1. Physical examination: A physical examination of the lesion, including its size, shape, color, and texture, can help diagnose granuloma gravidarum.
  2. Clinical examination: A physician will perform a thorough physical examination to assess the presence of granulomas on the skin, mucous membranes, and other organs. They will also take a detailed medical history to understand the symptoms and any underlying medical conditions.
  3. Blood tests: Blood tests can help determine the presence of any underlying medical conditions that may be contributing to the development of granuloma gravidarum.
  4. X – Ray  tests: Imaging tests such as X-rays, ultrasound, or MRI can help identify the location and size of the lesion and determine if it has spread to other parts of the body.
  5. Histological examination: A sample of the lesion is examined under a microscope to determine the type of cells present. This can help confirm the diagnosis of granuloma gravidarum.
  6. Biopsy: A biopsy is a procedure where a small sample of tissue is taken from the affected area and sent to a laboratory for analysis. This will help to confirm the diagnosis of granuloma gravidarum and rule out other conditions.
  7. Serum Blood tests: Blood tests are performed to assess the overall health of the patient and to rule out any underlying medical conditions that may be contributing to the development of granulomas.
  8. Imaging tests: Imaging tests, such as ultrasound, MRI, or CT scans, may be performed to help visualize the internal organs and determine the extent of the condition.
  9. Immunological tests: Immunological tests may be performed to assess the functioning of the immune system and to determine if it is contributing to the formation of granulomas.
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It is important to note that granuloma gravidarum is a rare condition and a combination of these tests may be required to diagnose it accurately. Early diagnosis and treatment of granuloma gravidarum is important to prevent complications during pregnancy.


The main treatments for granuloma gravidarum include:

  1. Topical Steroids: Topical steroids such as hydrocortisone cream can be applied to the affected area to reduce inflammation and itching.
  2. Antihistamines: Antihistamines such as diphenhydramine (Benadryl) can be used to relieve itching and reduce inflammation.
  3. Light Therapy: Light therapy, also known as phototherapy, uses ultraviolet light to treat granuloma gravidarum. This therapy is most effective when used in combination with topical steroids.
  4. Systemic Steroids: In severe cases of granuloma gravidarum, oral or intravenous steroids may be necessary to control the inflammation.
  5. Laser Therapy: Laser therapy uses a concentrated beam of light to remove the affected skin. This treatment is usually reserved for severe cases that have not responded to other treatments.
  6. Cryotherapy: Cryotherapy uses liquid nitrogen to freeze and removes the affected skin. This treatment is usually reserved for severe cases that have not responded to other treatments.
  7. Excisional treatment: This is a minimally invasive procedure that uses high-energy light to remove the lesion.
  8. Electrodesiccation and curettage: This is a procedure in which the lesion is scraped away with a curette and the remaining tissue is cauterized with an electric current.

It is important to note that some treatments may not be safe for use during pregnancy, so it is important to discuss treatment options with a healthcare provider.

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In general, the goal of treatment is to reduce inflammation, relieve itching, and prevent the spread of the condition. With proper treatment, most cases of granuloma gravidarum resolve after pregnancy.

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