Chronic infantile neurologic cutaneous and articular (CINCA) syndrome, also known as Neonatal-Onset Multisystem Inflammatory Disease (NOMID), is a rare, inherited autoimmune disease that primarily affects infants and children. It is characterized by persistent inflammation of the skin, joints, and nervous system, causing a range of symptoms that can affect multiple body systems.
The primary symptoms of CINCA syndrome include:
- Skin rashes: red, swollen and painful skin eruptions that are accompanied by itching.
- Joint swelling and pain: inflammation in the joints can lead to joint deformities, and restrict mobility.
- Chronic headache: persistent headaches and neck pain can be debilitating.
- Eye problems: this can include vision problems, sensitivity to light, and eye inflammation.
- Cognitive and developmental delays: this can include delayed speech and language, and intellectual disability.
- Neurological symptoms: seizures, hearing loss, and balance problems can also occur.
There is currently no cure for CINCA syndrome, and treatment is focused on controlling symptoms and reducing inflammation. This may involve the use of anti-inflammatory drugs, immunosuppressants, and pain management medications.