Tivozanib – Uses, Dosage, Side Effects, Interaction

Tivozanib inhibits growth factor receptors, treating renal cell carcinoma. In mice and rats, tivozanib inhibits tumor angiogenesis, tumor growth, and vascular permeability. Tivozanib was shown to frequently cause hypertension in clinical trials; hypertension must be managed before initiating therapy. Cardiac QT segment prolongation was reported in a tivozanib cardiac safety study, however, the reactions were not considered clinically serious. In clinical studies, levels of serum soluble VEGFR2 (sVEGFR2) decreased with time and this effect increased with tivozanib exposure, and sVEGFR2 may serve as a pharmacodynamic marker of VEGFR inhibition.

Use in Cancer

Tivozanib hydrochloride is approved to treat:

• Renal cell carcinoma (a type of kidney cancer) is advanced. It is used in adults whose disease has relapsed (come back) or is refractory (does not respond to treatment) after at least two other types of systemic therapy.

Tivozanib hydrochloride is also being studied in the treatment of other types of cancer.

Contraindications

• overactive thyroid gland
• a condition with low thyroid hormone levels
• an increased risk of bleeding
• high blood pressure
• a heart attack
• chronic heart failure
• a stroke
• nephrotic syndrome, a type of kidney disorder
• recent operation
• elevation of proteins in the urine
• impaired wound healing
• pregnancy
• a patient who is producing milk and breastfeeding
• a type of brain disorder called posterior reversible encephalopathy syndrome

Dosage

Strengths: 890 mcg; 1340 mcg

Renal Cell Carcinoma

• 1.34 mg orally once a day for 21 days followed by 7 days off (28-day cycle) until disease progression or unacceptable toxicity
• For adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following 2 or more prior systemic therapies

Renal Dose Adjustments

• Mild/moderate/severe renal impairment (CrCl 15 to 89 mL/min): No adjustment recommended.
• End-stage renal disease: Data not available

Liver Dose Adjustments

• Mild (total bilirubin less than or equal to the upper limit of normal [ULN] with AST greater than ULN or total bilirubin greater than 1 to 1.5 x ULN with any AST) hepatic impairment: No adjustment recommended.
• Moderate (total bilirubin greater than 1.5 to 3 x ULN with any AST) hepatic impairment: Reduce dose to 0.89 mg orally once a day for 21 days followed by 7 days off (28-day cycle)
• Severe (total bilirubin greater than 3 to 10 x ULN with any AST) hepatic impairment: Data not available

Dose Adjustments

Initiate medical management for diarrhea, nausea, or vomiting prior to dose interruption or reduction.

Recommended dose modifications:

• Reduce the dose to 0.89 mg orally once a day for 21 days followed by 7 days off for a 28-day cycle.

Dose Modifications for Adverse Reactions:
HYPERTENSION:

• Grade 3: Withhold therapy for Grade 3 that persists despite antihypertensive therapy; resume at reduced dose when hypertension is controlled at less than or equal to Grade 2.
• Grade 4: Permanently discontinue therapy.

CARDIAC FAILURE:

• Grade 3: Withhold until improvement to Grade 0, 1, or baseline; resume at reduced dose or discontinue therapy based on severity and persistence of adverse reaction.
• Grade 4: Permanently discontinue therapy.

ARTERIAL THROMBOEMBOLIC EVENTS:

• Any Grade: Permanently discontinue therapy.

HEMORRHAGIC EVENTS:

• Grade 3 or 4: Permanently discontinue therapy.

PROTEINURIA:

• Two grams or greater proteinuria in 24 hours: Withhold therapy until less than or equal to 2 grams of proteinuria in 24 hours; resume at a reduced dose; permanently discontinue for nephrotic syndrome.

REVERSE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME:

• Any Grade: Permanently discontinue therapy.

OTHER ADVERSE REACTIONS:

• Persistent or intolerable Grade 2 or 3 adverse reaction:
• Grade 4 laboratory abnormality: Withhold therapy until improvement to Grade 0, 1, or baseline; resume at a reduced dose.
• Grade 4 adverse reaction: Permanently discontinue therapy.

Administration advice:

• This drug can be taken with or without food.
• Swallow the capsule whole with a glass of water.
• Swallow the capsule whole; do not open, crush, or chew the capsule.
• If a dose is missed, the next dose should be taken at the next scheduled time; do not take two doses at the same time.
• In the case of vomiting, a replacement dose should not be taken; the next dose should be taken at the next scheduled time.

Side Effects

The Most Common

• diarrhea
• nausea
• vomiting
• fatigue
• loss of appetite
• weight loss
• voice hoarseness
• back pain
• mouth sores
• cough
• shortness of breath
• unusual bruising or bleeding
• bloody or black and tarry stools
• blood in urine
• vomiting or coughing up blood
• bleeding from gums
• seizures, headaches, vision changes, or confusion
• redness, swelling, and pain on hands and/or feet
• confusion, headache, dizziness, chest pain, or shortness of breath
• shortness of breath or swelling of ankles
• chest pain or pressure; numbness or weakness on one side of body; pain in arms, back, neck or jaw; difficulty talking; shortness of breath; sudden severe headache; vision changes; or swelling in arms or legs

More common

• Agitation
• back pain
• black, tarry stools
• bleeding from the rectum or bloody stools
• bleeding gums
• blood in the urine
• bloody nose
• blurred vision
• change in consciousness
• cloudy urine
• collection of blood under the skin
• confusion
• confusion as to time, place, or person
• constipation
• coughing or spitting up blood
• decreased urine output
• deep, dark purple bruise
• depressed mood
• depression
• difficulty in swallowing
• dilated neck veins
• dizziness
• drowsiness
• dry skin and hair
• enlarged pupils
• feeling cold
• fever
• hair loss
• heavy nonmenstrual vaginal bleeding
• hoarseness or husky voice
• holding false beliefs that cannot be changed by fact
• hostility
• increased menstrual flow or vaginal bleeding
• increased sensitivity of the eyes to light
• increased sweating, possibly with fever or cold, clammy skin
• irregular breathing
• irregular heartbeat
• irritability
• itching
• lethargy
• loss of consciousness
• muscle cramps, stiffness, twitching
• nausea
• nervousness
• nosebleeds
• pain or discomfort in the arms, jaw, back, or neck
• pain, redness, or swelling in the arm or leg
• pains in the chest, groin, or legs, especially calves of the legs
• paralysis
• pounding in the ears
• prolonged bleeding from cuts
• red or dark brown urine
• red or black, tarry stools
• seeing, hearing, or feeling things that are not there
• seizures
• sensitivity to heat
• severe chest pain
• severe headache
• slow or fast heartbeat
• sore throat
• stiff or sore neck
• stupor
• sudden loss of coordination
• sudden onset of slurred speech
• sudden onset of trouble breathing for no apparent reason
• sudden vision changes
• swelling of the face, fingers, feet, or lower legs
• tightness in the chest
• trouble breathing
• trouble healing
• trouble sleeping
• unusual excitement, nervousness, or restlessness
• unusual tiredness or weakness
• voice changes
• vomiting
• vomiting of blood or material that looks like coffee grounds
• weight gain or loss

Rare

• Blistering, crusting, irritation, itching, or reddening of the skin
• blistering, peeling, loosening of the skin
• cracked, dry, scaly skin
• cough
• decreased appetite
• diarrhea
• dry, flaky, scaling skin on the scalp, eyebrows, near the ears, and around the nose
• increased sensitivity of skin to sunlight
• joint or muscle pain
• lack or loss of strength
• rash with flat lesions or small raised lesions on the skins
• red, irritated eyes
• redness or other discoloration of skin
• severe sunburn
• skin rash, encrusted, scaly and oozing
• sores, ulcers, or white spots in the mouth or on the lips
• swelling
• swelling or inflammation of the mouth

Drug interactions

DRUG	INTERACTION
Abaloparatide	The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Tivozanib.
Abemaciclib	Tivozanib may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Abrocitinib	The serum concentration of Tivozanib can be increased when it is combined with Abrocitinib.
Acetaminophen	The metabolism of Tivozanib can be increased when combined with Acetaminophen.
Afatinib	Tivozanib may decrease the excretion rate of Afatinib which could result in a higher serum level.
Allopurinol	Tivozanib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Alpelisib	The metabolism of Tivozanib can be increased when combined with Alpelisib.
Ambrisentan	The serum concentration of Tivozanib can be increased when it is combined with Ambrisentan.
Aminoglutethimide	The metabolism of Tivozanib can be increased when combined with Aminoglutethimide.
Amiodarone	The serum concentration of Tivozanib can be increased when it is combined with Amiodarone.
Amobarbital	The metabolism of Tivozanib can be increased when combined with Amobarbital.
Amprenavir	The metabolism of Tivozanib can be increased when combined with Amprenavir.
Apalutamide	The metabolism of Tivozanib can be increased when combined with Apalutamide.
Apixaban	Tivozanib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Armodafinil	The metabolism of Tivozanib can be increased when combined with Armodafinil.
Arsenic trioxide	The serum concentration of Tivozanib can be increased when it is combined with Arsenic trioxide.
Artemether	The metabolism of Tivozanib can be increased when combined with Artemether.
Articaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Articaine.
Asciminib	The serum concentration of Tivozanib can be increased when it is combined with Asciminib.
Asunaprevir	The metabolism of Tivozanib can be increased when combined with Asunaprevir.
Avanafil	The serum concentration of Tivozanib can be increased when it is combined with Avanafil.
Avatrombopag	The serum concentration of Avatrombopag can be increased when it is combined with Tivozanib.
Axitinib	The serum concentration of Axitinib can be increased when it is combined with Tivozanib.
Beclomethasone	The metabolism of Tivozanib can be increased when combined with Beclomethasone dipropionate.
Belantamab	The serum concentration of Belantamab mafodotin can be increased when it is combined with Tivozanib.
Belinostat	The serum concentration of Tivozanib can be increased when it is combined with Belinostat.
Belumosudil	The serum concentration of Tivozanib can be increased when it is combined with Belumosudil.
Bendamustine	The serum concentration of Bendamustine can be increased when it is combined with Tivozanib.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Benzocaine.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Benzyl alcohol.
Berotralstat	The serum concentration of Berotralstat can be increased when it is combined with Tivozanib.
Betamethasone	The metabolism of Tivozanib can be increased when combined with Betamethasone.
Betrixaban	The serum concentration of Betrixaban can be increased when it is combined with Tivozanib.
Bexarotene	The metabolism of Tivozanib can be increased when combined with Bexarotene.
Binimetinib	The serum concentration of Binimetinib can be increased when it is combined with Tivozanib.
Bisoprolol	The serum concentration of Tivozanib can be increased when it is combined with Bisoprolol.
Bortezomib	The serum concentration of Bortezomib can be increased when it is combined with Tivozanib.
Bosentan	The metabolism of Tivozanib can be increased when combined with Bosentan.
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Tivozanib.
Brentuximab vedotin	The serum concentration of Brentuximab vedotin can be increased when it is combined with Tivozanib.
Brigatinib	The metabolism of Tivozanib can be increased when combined with Brigatinib.
Budesonide	The metabolism of Tivozanib can be increased when combined with Budesonide.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Bupivacaine.
Butacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Butacaine.
Butalbital	The metabolism of Tivozanib can be increased when combined with Butalbital.
Butamben	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Butamben.
Cabazitaxel	The serum concentration of Cabazitaxel can be increased when it is combined with Tivozanib.
Cabergoline	The serum concentration of Cabergoline can be increased when it is combined with Tivozanib.
Calcitriol	The metabolism of Tivozanib can be increased when combined with Calcitriol.
Canagliflozin	The serum concentration of Tivozanib can be increased when it is combined with Canagliflozin.
Capmatinib	The serum concentration of Tivozanib can be increased when it is combined with Capmatinib.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Capsaicin.
Carbamazepine	The metabolism of Tivozanib can be increased when combined with Carbamazepine.
Carbimazole	The therapeutic efficacy of Carbimazole can be decreased when used in combination with Tivozanib.
Carfilzomib	The serum concentration of Tivozanib can be increased when it is combined with Carfilzomib.
Carvedilol	The serum concentration of Tivozanib can be increased when it is combined with Carvedilol.
Cefradine	The metabolism of Tivozanib can be increased when combined with Cefradine.
Celecoxib	Tivozanib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Cenobamate	The metabolism of Tivozanib can be increased when combined with Cenobamate.
Ceritinib	The serum concentration of Ceritinib can be increased when it is combined with Tivozanib.
Cerivastatin	The metabolism of Tivozanib can be increased when combined with Cerivastatin.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Chloroprocaine.
Chlorphenesin	The metabolism of Tivozanib can be increased when combined with Chlorphenesin.
Chlorpromazine	The metabolism of Tivozanib can be increased when combined with Chlorpromazine.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Cinchocaine.
Cladribine	Tivozanib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Clarithromycin	The serum concentration of Tivozanib can be increased when it is combined with Clarithromycin.
Clevidipine	The metabolism of Tivozanib can be increased when combined with Clevidipine.
Clobazam	The metabolism of Tivozanib can be increased when combined with Clobazam.
Clobetasol	The metabolism of Tivozanib can be increased when combined with Clobetasol.
Clobetasol	The metabolism of Tivozanib can be increased when combined with Clobetasol propionate.
Clofarabine	Tivozanib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Clofazimine	The serum concentration of Tivozanib can be increased when it is combined with Clofazimine.
Clofibrate	The metabolism of Tivozanib can be increased when combined with Clofibrate.
Clomifene	The serum concentration of Tivozanib can be increased when it is combined with Clomifene.
Clozapine	The metabolism of Tivozanib can be increased when combined with Clozapine.
Cobicistat	The serum concentration of Tivozanib can be increased when it is combined with Cobicistat.
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Tivozanib.
Cocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Cocaine.
Colchicine	The serum concentration of Tivozanib can be increased when it is combined with Colchicine.
Conivaptan	The serum concentration of Tivozanib can be increased when it is combined with Conivaptan.
Conjugated	Tivozanib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Copanlisib	Tivozanib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Corticotropin	The metabolism of Tivozanib can be increased when combined with Corticotropin.
Cortisone acetate	The metabolism of Tivozanib can be increased when combined with Cortisone acetate.
Crizotinib	The serum concentration of Tivozanib can be increased when it is combined with Crizotinib.
Curcumin	The serum concentration of Tivozanib can be increased when it is combined with Curcumin.
Cyclophosphamide	The metabolism of Tivozanib can be increased when combined with Cyclophosphamide.
Cyclosporine	The serum concentration of Tivozanib can be increased when it is combined with Cyclosporine.
Dabigatran etexilate	The serum concentration of Tivozanib can be increased when it is combined with Dabigatran etexilate.
Dabrafenib	The metabolism of Tivozanib can be increased when combined with Dabrafenib.
Daclatasvir	The serum concentration of Tivozanib can be increased when it is combined with Daclatasvir.
Dacomitinib	Tivozanib may decrease the excretion rate of Dacomitinib which could result in a higher serum level.
Dactinomycin	Tivozanib may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Daptomycin	The serum concentration of Tivozanib can be increased when it is combined with Daptomycin.
Darbepoetin alfa	The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tivozanib.
Darolutamide	Tivozanib may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Darunavir	The serum concentration of Tivozanib can be increased when it is combined with Darunavir.
Dasabuvir	The serum concentration of Tivozanib can be increased when it is combined with Dasabuvir.
Dasatinib	Tivozanib may decrease the excretion rate of Dasatinib which could result in a higher serum level.

Daunorubicin	Tivozanib may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Deferasirox	The metabolism of Tivozanib can be increased when combined with Deferasirox.
Delafloxacin	The metabolism of Tivozanib can be increased when combined with Delafloxacin.
Desonide	The metabolism of Tivozanib can be increased when combined with Desonide.
Dexamethasone	The metabolism of Tivozanib can be increased when combined with Dexamethasone.
Dexamethasone acetate	The metabolism of Tivozanib can be increased when combined with Dexamethasone acetate.
Dicloxacillin	The metabolism of Tivozanib can be increased when combined with Dicloxacillin.
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with Tivozanib.
Digoxin	The serum concentration of Digoxin can be increased when it is combined with Tivozanib.
Diosmin	The serum concentration of Tivozanib can be increased when it is combined with Diosmin.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Diphenhydramine.
Dolutegravir	Tivozanib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Donepezil	Tivozanib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Doxorubicin	Tivozanib may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Dronedarone	The serum concentration of Tivozanib can be increased when it is combined with Dronedarone.
Duvelisib	Tivozanib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Dyclonine.
Edoxaban	The serum concentration of Tivozanib can be increased when it is combined with Edoxaban.
Efavirenz	The metabolism of Tivozanib can be increased when combined with Efavirenz.
Elagolix	The serum concentration of Tivozanib can be increased when it is combined with Elagolix.
Elbasvir	The serum concentration of Tivozanib can be increased when it is combined with Elbasvir.
Eliglustat	The serum concentration of Tivozanib can be increased when it is combined with Eliglustat.
Enasidenib	The metabolism of Tivozanib can be increased when combined with Enasidenib.
Enfortumab vedotin	The serum concentration of Enfortumab vedotin can be increased when it is combined with Tivozanib.
Entrectinib	The serum concentration of Tivozanib can be increased when it is combined with Entrectinib.
Enzalutamide	The metabolism of Tivozanib can be increased when combined with Enzalutamide.
Erdafitinib	The serum concentration of Tivozanib can be increased when it is combined with Erdafitinib.
Ertugliflozin	Tivozanib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Erythromycin	The serum concentration of Tivozanib can be increased when it is combined with Erythromycin.
Erythropoietin	The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Tivozanib.
Esketamine	The metabolism of Tivozanib can be increased when combined with Esketamine.
Eslicarbazepine	The metabolism of Tivozanib can be increased when combined with Eslicarbazepine.
Eslicarbazepine acetate	The metabolism of Tivozanib can be increased when combined with Eslicarbazepine acetate.
Estradiol acetate	The metabolism of Tivozanib can be increased when combined with Estradiol acetate.
Estradiol benzoate	The metabolism of Tivozanib can be increased when combined with Estradiol benzoate.
Estradiol cypionate	The metabolism of Tivozanib can be increased when combined with Estradiol cypionate.
Estradiol dienanthate	The metabolism of Tivozanib can be increased when combined with Estradiol dienanthate.
Estradiol valerate	The metabolism of Tivozanib can be increased when combined with Estradiol valerate.
Ethanol	The metabolism of Tivozanib can be increased when combined with Ethanol.
Ethotoin	The metabolism of Tivozanib can be increased when combined with Ethotoin.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Ethyl chloride.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Etidocaine.
Etoposide	The metabolism of Tivozanib can be increased when combined with Etoposide.
Etravirine	The metabolism of Tivozanib can be increased when combined with Etravirine.
Everolimus	The serum concentration of Tivozanib can be increased when it is combined with Everolimus.
Ezetimibe	Tivozanib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Favipiravir	The serum concentration of Tivozanib can be increased when it is combined with Favipiravir.
Fedratinib	The serum concentration of Tivozanib can be increased when it is combined with Fedratinib.
Felbamate	The metabolism of Tivozanib can be increased when combined with Felbamate.
Fexofenadine	The serum concentration of Tivozanib can be increased when it is combined with Fexofenadine.
Flibanserin	The serum concentration of Tivozanib can be increased when it is combined with Flibanserin.
Flucloxacillin	The metabolism of Tivozanib can be increased when combined with Flucloxacillin.
Fluconazole	The serum concentration of Tivozanib can be increased when it is combined with Fluconazole.
Flunisolide	The metabolism of Tivozanib can be increased when combined with Flunisolide.
Fluocinolone acetonide	The metabolism of Tivozanib can be increased when combined with Fluocinolone acetonide.
Fluorouracil	Tivozanib may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Folic acid	Tivozanib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Follitropin	The therapeutic efficacy of Follitropin can be decreased when used in combination with Tivozanib.
Formestane	The metabolism of Tivozanib can be increased when combined with Formestane.
Fosaprepitant	The metabolism of Tivozanib can be increased when combined with Fosaprepitant.
Fosphenytoin	The metabolism of Tivozanib can be increased when combined with Fosphenytoin.
Fostemsavir	Tivozanib may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Futibatinib	The serum concentration of Futibatinib can be increased when it is combined with Tivozanib.
Gefitinib	Tivozanib may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Gemcitabine	The serum concentration of Gemcitabine can be increased when it is combined with Tivozanib.
Gilteritinib	The serum concentration of Gilteritinib can be increased when it is combined with Tivozanib.
Glasdegib	Tivozanib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Glecaprevir	Tivozanib may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Glyburide	Tivozanib may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glycerol phenylbutyrate	The metabolism of Tivozanib can be increased when combined with Glycerol phenylbutyrate.
Grazoprevir	The serum concentration of Tivozanib can be increased when it is combined with Grazoprevir.
Griseofulvin	The metabolism of Tivozanib can be increased when combined with Griseofulvin.
Hydrocortamate	The metabolism of Tivozanib can be increased when combined with Hydrocortamate.
Hydrocortisone	The metabolism of Tivozanib can be increased when combined with Hydrocortisone.
Hydrocortisone acetate	The metabolism of Tivozanib can be increased when combined with Hydrocortisone acetate.
Hydrocortisone	The metabolism of Tivozanib can be increased when combined with Hydrocortisone butyrate.
Hydrocortisone	The metabolism of Tivozanib can be increased when combined with Hydrocortisone probutate.
Hydrocortisone	The metabolism of Tivozanib can be increased when combined with Hydrocortisone succinate.
Hydrocortisone valerate	The metabolism of Tivozanib can be increased when combined with Hydrocortisone valerate.
Idelalisib	Tivozanib may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Ifosfamide	The metabolism of Tivozanib can be increased when combined with Ifosfamide.
Imatinib	Tivozanib may decrease the excretion rate of Imatinib which could result in a higher serum level.
Imipramine	The serum concentration of Imipramine can be increased when it is combined with Tivozanib.
Indacaterol	The serum concentration of Tivozanib can be increased when it is combined with Indacaterol.
Inotuzumab	The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Tivozanib.
Irinotecan	Tivozanib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Isavuconazole	The metabolism of Tivozanib can be increased when combined with Isavuconazole.
Isavuconazonium	The metabolism of Tivozanib can be increased when combined with Isavuconazonium.
Istradefylline	The serum concentration of Tivozanib can be increased when it is combined with Istradefylline.
Itraconazole	The serum concentration of Tivozanib can be increased when it is combined with Itraconazole.
Ivacaftor	The serum concentration of Tivozanib can be increased when it is combined with Ivacaftor.
Ivermectin	Tivozanib may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Ivosidenib	The metabolism of Tivozanib can be increased when combined with Ivosidenib.
Ixabepilone	The serum concentration of Tivozanib can be increased when it is combined with Ixabepilone.
Ketamine	The metabolism of Tivozanib can be increased when combined with Ketamine.
Ketoconazole	The serum concentration of Tivozanib can be increased when it is combined with Ketoconazole.
Lamivudine	Tivozanib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Lansoprazole	The metabolism of Tivozanib can be increased when combined with Lansoprazole.
Lapatinib	The serum concentration of Tivozanib can be increased when it is combined with Lapatinib.
Larotrectinib	The serum concentration of Larotrectinib can be increased when it is combined with Tivozanib.

Lasmiditan	The serum concentration of Tivozanib can be increased when it is combined with Lasmiditan.
Ledipasvir	The serum concentration of Tivozanib can be increased when it is combined with Ledipasvir.
Lefamulin	The serum concentration of Lefamulin can be increased when it is combined with Tivozanib.
Leflunomide	Tivozanib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Lemborexant	The serum concentration of Lemborexant can be increased when it is combined with Tivozanib.
Lenvatinib	Tivozanib may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Levobupivacaine.
Levoketoconazole	The serum concentration of Tivozanib can be increased when it is combined with Levoketoconazole.
Levothyroxine	The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Tivozanib.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Lidocaine.
Linagliptin	The serum concentration of Tivozanib can be increased when it is combined with Linagliptin.
Liothyronine	The therapeutic efficacy of Liothyronine can be decreased when used in combination with Tivozanib.
Liotrix	The therapeutic efficacy of Liotrix can be decreased when used in combination with Tivozanib.
Lomitapide	The serum concentration of Tivozanib can be increased when it is combined with Lomitapide.
Lonafarnib	The serum concentration of Tivozanib can be increased when it is combined with Lonafarnib.
Loncastuximab	The serum concentration of Loncastuximab tesirine can be increased when it is combined with Tivozanib.
Loperamide	The serum concentration of Tivozanib can be increased when it is combined with Loperamide.
Lopinavir	The serum concentration of Tivozanib can be increased when it is combined with Lopinavir.
Lorlatinib	The metabolism of Tivozanib can be increased when combined with Lorlatinib.
Loxapine	The serum concentration of Tivozanib can be increased when it is combined with Loxapine.
Lumacaftor	The metabolism of Tivozanib can be increased when combined with Lumacaftor.
Lusutrombopag	Tivozanib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Mannitol	The serum concentration of Tivozanib can be increased when it is combined with Mannitol.
Maribavir	The serum concentration of Tivozanib can be increased when it is combined with Maribavir.
Medroxyproge	The metabolism of Tivozanib can be increased when combined with Medroxyprogesterone acetate.
Mefloquine	The serum concentration of Tivozanib can be increased when it is combined with Mefloquine.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Meloxicam.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Mepivacaine.
Methimazole	The therapeutic efficacy of Methimazole can be decreased when used in combination with Tivozanib.
Methotrexate	Tivozanib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Methoxy	The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tivozanib.
Methylene blue	The serum concentration of Tivozanib can be increased when it is combined with Methylene blue.
Methylphenobarbital	The metabolism of Tivozanib can be increased when combined with Methylphenobarbital.
Methylprednisolone	The metabolism of Tivozanib can be increased when combined with Methylprednisolone.
Metyrapone	The metabolism of Tivozanib can be increased when combined with Metyrapone.
Midostaurin	The metabolism of Tivozanib can be increased when combined with Midostaurin.
Mifepristone	The metabolism of Tivozanib can be increased when combined with Mifepristone.
Mirabegron	The serum concentration of Tivozanib can be increased when it is combined with Mirabegron.
Mitapivat	The metabolism of Tivozanib can be increased when combined with Mitapivat.
Mitotane	The metabolism of Tivozanib can be increased when combined with Mitotane.
Mitoxantrone	Tivozanib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Modafinil	The metabolism of Tivozanib can be increased when combined with Modafinil.
Morphine	The serum concentration of Tivozanib can be increased when it is combined with Morphine.
Mycophenolate	Tivozanib may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
Nafcillin	The metabolism of Tivozanib can be increased when combined with Nafcillin.
Neratinib	The serum concentration of Tivozanib can be increased when it is combined with Neratinib.
Netupitant	The serum concentration of Tivozanib can be increased when it is combined with Netupitant.
Nifedipine	The metabolism of Tivozanib can be increased when combined with Nifedipine.
Nilotinib	Tivozanib may decrease the excretion rate of Nilotinib which could result in a higher serum level.
Nintedanib	The serum concentration of Tivozanib can be increased when it is combined with Nintedanib.
Nitrofurantoin	Tivozanib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Norgestimate	The metabolism of Tivozanib can be increased when combined with Norgestimate.
Nortriptyline	The serum concentration of Nortriptyline can be increased when it is combined with Tivozanib.
Omadacycline	The serum concentration of Omadacycline can be increased when it is combined with Tivozanib.
Ombitasvir	Tivozanib may decrease the excretion rate of Ombitasvir which could result in a higher serum level.
Omeprazole	The metabolism of Tivozanib can be increased when combined with Omeprazole.
Oritavancin	The metabolism of Tivozanib can be increased when combined with Oritavancin.
Osimertinib	Tivozanib may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Oxaliplatin	Tivozanib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Oxcarbazepine	The metabolism of Tivozanib can be increased when combined with Oxcarbazepine.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Oxetacaine.
Oxiconazole	The metabolism of Tivozanib can be increased when combined with Oxiconazole.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Oxybuprocaine.
Ozanimod	Tivozanib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Paclitaxel	The metabolism of Tivozanib can be increased when combined with Paclitaxel.
Pacritinib	The serum concentration of Tivozanib can be increased when it is combined with Pacritinib.
Palbociclib	Tivozanib may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Paliperidone	The serum concentration of Tivozanib can be increased when it is combined with Paliperidone.
Panobinostat	The serum concentration of Panobinostat can be increased when it is combined with Tivozanib.
Parathyroid hormone	The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Tivozanib.
Paritaprevir	The serum concentration of Tivozanib can be increased when it is combined with Paritaprevir.
Pazopanib	Tivozanib may decrease the excretion rate of Pazopanib which could result in a higher serum level.
Peginesatide	The risk or severity of Thrombosis can be increased when Peginesatide is combined with Tivozanib.
Pegvisomant	The metabolism of Tivozanib can be increased when combined with Pegvisomant.
Pentobarbital	The metabolism of Tivozanib can be increased when combined with Pentobarbital.
Perampanel	The metabolism of Tivozanib can be increased when combined with Perampanel.
Phenobarbital	The metabolism of Tivozanib can be increased when combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Phenol.
Phenylbutazone	The metabolism of Tivozanib can be increased when combined with Phenylbutazone.
Phenytoin	The metabolism of Tivozanib can be increased when combined with Phenytoin.
Pibrentasvir	Tivozanib may decrease the excretion rate of Pibrentasvir which could result in a higher serum level.
Pitavastatin	Tivozanib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Pitolisant	The metabolism of Tivozanib can be increased when combined with Pitolisant.
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with Tivozanib.
Ponatinib	Tivozanib may decrease the excretion rate of Ponatinib which could result in a higher serum level.
Posaconazole	The serum concentration of Tivozanib can be increased when it is combined with Posaconazole.
Potassium Iodide	The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Tivozanib.
Potassium perchlorate	The therapeutic efficacy of Potassium perchlorate can be decreased when used in combination with Tivozanib.
Pralatrexate	Tivozanib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Pralsetinib	The metabolism of Tivozanib can be increased when combined with Pralsetinib.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Pramocaine.
Pravastatin	Tivozanib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Prazosin	Tivozanib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Prednicarbate	The metabolism of Tivozanib can be increased when combined with Prednicarbate.
Prednisolone	The metabolism of Tivozanib can be increased when combined with Prednisolone.
Prednisolone acetate	The metabolism of Tivozanib can be increased when combined with Prednisolone acetate.
Prednisolone phosphate	The serum concentration of Prednisolone phosphate can be increased when it is combined with Tivozanib.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Prilocaine.
Primidone	The metabolism of Tivozanib can be increased when combined with Primidone.
Probenecid	The metabolism of Tivozanib can be increased when combined with Probenecid.

Procaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Procaine.
Progesterone	The metabolism of Tivozanib can be increased when combined with Progesterone.
Propafenone	The serum concentration of Tivozanib can be increased when it is combined with Propafenone.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Proparacaine.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Propoxycaine.
Propylthiouracil	The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Tivozanib.
Protirelin	The therapeutic efficacy of Protirelin can be decreased when used in combination with Tivozanib.
Quinidine	The serum concentration of Tivozanib can be increased when it is combined with Quinidine.
Quinine	The metabolism of Tivozanib can be increased when combined with Quinine.
Raloxifene	Tivozanib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Ranolazine	The serum concentration of Tivozanib can be increased when it is combined with Ranolazine.
Regorafenib	The serum concentration of Tivozanib can be increased when it is combined with Regorafenib.
Relugolix	The serum concentration of Relugolix can be increased when it is combined with Tivozanib.
Reserpine	The serum concentration of Tivozanib can be increased when it is combined with Reserpine.
Revefenacin	Tivozanib may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Rifabutin	The metabolism of Tivozanib can be increased when combined with Rifabutin.
Rifampicin	The metabolism of Tivozanib can be increased when combined with Rifampicin.
Rifamycin	The metabolism of Tivozanib can be increased when combined with Rifamycin.
Rifapentine	The metabolism of Tivozanib can be increased when combined with Rifapentine.
Rifaximin	The metabolism of Tivozanib can be increased when combined with Rifaximin.
Riluzole	Tivozanib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Rimegepant	The serum concentration of Rimegepant can be increased when it is combined with Tivozanib.
Rimexolone	The metabolism of Tivozanib can be increased when combined with Rimexolone.
Riociguat	Tivozanib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Ripretinib	Tivozanib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Ritonavir	Tivozanib may decrease the excretion rate of Ritonavir which could result in a higher serum level.
Rivaroxaban	Tivozanib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Rofecoxib	The metabolism of Tivozanib can be increased when combined with Rofecoxib.
Rolapitant	The serum concentration of Tivozanib can be increased when it is combined with Rolapitant.
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with Tivozanib.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Ropivacaine.
Rosuvastatin	Tivozanib may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Rucaparib	Tivozanib may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Rufinamide	The metabolism of Tivozanib can be increased when combined with Rufinamide.
Salmon calcitonin	The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Tivozanib.
Sapropterin	The serum concentration of Tivozanib can be increased when it is combined with Sapropterin.
Saquinavir	The serum concentration of Tivozanib can be increased when it is combined with Saquinavir.
Sarecycline	The serum concentration of Tivozanib can be increased when it is combined with Sarecycline.
Sarilumab	The metabolism of Tivozanib can be increased when combined with Sarilumab.
Secobarbital	The metabolism of Tivozanib can be increased when combined with Secobarbital.
Selexipag	The serum concentration of Tivozanib can be increased when it is combined with Selexipag.
Selumetinib	Tivozanib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Sildenafil	The serum concentration of Tivozanib can be increased when it is combined with Sildenafil.
Silodosin	The serum concentration of Tivozanib can be increased when it is combined with Silodosin.
Siltuximab	The metabolism of Tivozanib can be increased when combined with Siltuximab.
Simeprevir	Tivozanib may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Simvastatin	The serum concentration of Tivozanib can be increased when it is combined with Simvastatin.
Sirolimus	The serum concentration of Sirolimus can be increased when it is combined with Tivozanib.
Sitagliptin	The serum concentration of Tivozanib can be increased when it is combined with Sitagliptin.
Sofosbuvir	Tivozanib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Sorafenib	Tivozanib may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Sotagliflozin	The serum concentration of Tivozanib can be increased when it is combined with Sotagliflozin.
Sotorasib	The serum concentration of Tivozanib can be increased when it is combined with Sotorasib.
St. John’s Wort	The metabolism of Tivozanib can be increased when combined with St. John’s Wort.
Stiripentol	The excretion of Tivozanib can be decreased when combined with Stiripentol.
Sulfasalazine	Tivozanib may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Sulfinpyrazone	The metabolism of Tivozanib can be increased when combined with Sulfinpyrazone.
Sumatriptan	Tivozanib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Suvorexant	The serum concentration of Tivozanib can be increased when it is combined with Suvorexant.
Tacrolimus	The serum concentration of Tivozanib can be increased when it is combined with Tacrolimus.
Talazoparib	Tivozanib may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Tamoxifen	The metabolism of Tivozanib can be increased when combined with Tamoxifen.
Tazemetostat	Tivozanib may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Technetium	The serum concentration of Tivozanib can be increased when it is combined with Technetium Tc-99m sestamibi.
Tecovirimat	The metabolism of Tivozanib can be increased when combined with Tecovirimat.
Tegaserod	Tivozanib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Telaprevir	The serum concentration of Tivozanib can be increased when it is combined with Telaprevir.
Temsirolimus	The serum concentration of Tivozanib can be increased when it is combined with Temsirolimus.
Teniposide	Tivozanib may decrease the excretion rate of Teniposide which could result in a higher serum level.
Tenofovir alafenamide	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Tivozanib.
Tenofovir disoproxil	The serum concentration of Tivozanib can be increased when it is combined with Tenofovir disoproxil.
Tepotinib	The serum concentration of Tivozanib can be increased when it is combined with Tepotinib.
Terbinafine	The metabolism of Tivozanib can be increased when combined with Terbinafine.
Teriflunomide	Tivozanib may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Teriparatide	The therapeutic efficacy of Teriparatide can be decreased when used in combination with Tivozanib.
Testosterone	The metabolism of Tivozanib can be increased when combined with Testosterone.
Testosterone cypionate	The metabolism of Tivozanib can be increased when combined with Testosterone cypionate.
Testosterone enanthate	The metabolism of Tivozanib can be increased when combined with Testosterone enanthate.
Testosterone	The metabolism of Tivozanib can be increased when combined with Testosterone undecanoate.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Tivozanib is combined with Tetracaine.
Tezacaftor	The serum concentration of Tivozanib can be increased when it is combined with Tezacaftor.
Thiopental	The metabolism of Tivozanib can be increased when combined with Thiopental.
Thyroid, porcine	The therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Tivozanib.
Thyrotropin alfa	The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Tivozanib.
Ticagrelor	The serum concentration of Tivozanib can be increased when it is combined with Ticagrelor.
Tipranavir	The serum concentration of Tivozanib can be increased when it is combined with Tipranavir.
Tocilizumab	The metabolism of Tivozanib can be increased when combined with Tocilizumab.
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Tivozanib.
Topotecan	Tivozanib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Toremifene	The serum concentration of Tivozanib can be increased when it is combined with Toremifene.
Trametinib	The metabolism of Tivozanib can be increased when combined with Trametinib.
Trastuzumab	The serum concentration of Trastuzumab emtansine can be increased when it is combined with Tivozanib.
Triamcinolone	The metabolism of Tivozanib can be increased when combined with Triamcinolone.
Trilaciclib	Tivozanib may decrease the excretion rate of Trilaciclib which could result in a higher serum level.
Trimipramine	The serum concentration of Trimipramine can be increased when it is combined with Tivozanib.
Troglitazone	The metabolism of Tivozanib can be increased when combined with Troglitazone.
Tucatinib	Tucatinib may decrease the excretion rate of Tivozanib which could result in a higher serum level.
Ubrogepant	The serum concentration of Ubrogepant can be increased when it is combined with Tivozanib.
Umbralisib	The serum concentration of Tivozanib can be increased when it is combined with Umbralisib.
Umeclidinium	The serum concentration of Tivozanib can be increased when it is combined with Umeclidinium.

Vandetanib	The serum concentration of Tivozanib can be increased when it is combined with Vandetanib.
Vardenafil	The serum concentration of Tivozanib can be increased when it is combined with Vardenafil.
Velpatasvir	Tivozanib may decrease the excretion rate of Velpatasvir which could result in a higher serum level.
Vemurafenib	The metabolism of Tivozanib can be increased when combined with Vemurafenib.
Venetoclax	Tivozanib may decrease the excretion rate of Venetoclax which could result in a higher serum level.
Verapamil	The serum concentration of Tivozanib can be increased when it is combined with Verapamil.
Vinblastine	The metabolism of Tivozanib can be increased when combined with Vinblastine.
Vincristine	Tivozanib may decrease the excretion rate of Vincristine which could result in a higher serum level.
Vinflunine	The serum concentration of Vinflunine can be increased when it is combined with Tivozanib.
Vitamin E	The metabolism of Tivozanib can be increased when combined with Vitamin E.
Voclosporin	The serum concentration of Tivozanib can be increased when it is combined with Voclosporin.
Vorapaxar	The serum concentration of Tivozanib can be increased when it is combined with Vorapaxar.
Voriconazole	The serum concentration of Tivozanib can be increased when it is combined with Voriconazole.
Voxilaprevir	Tivozanib may decrease the excretion rate of Voxilaprevir which could result in a higher serum level.
Warfarin	The metabolism of Tivozanib can be increased when combined with Warfarin.
Zidovudine	Tivozanib may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Zonisamide	The serum concentration of Tivozanib can be increased when it is combined with Zonisamide.

Pregnancy and Lactation

US FDA pregnancy category: Not assigned.

Pregnancy

Based on findings in animal studies and its mechanism of action, this drug can cause fetal harm when administered during pregnancy. This drug can harm a developing fetus. Adequate methods of contraception should be encouraged. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.  Advise females of reproductive potential to use effective contraception during therapy and for 1 month after. Advise males with female partners of reproductive potential to use effective contraception during therapy and for 1 month after. This drug can impair fertility in females and males of reproductive potential.

Lactation

• Use is not recommended.
• Excreted into human milk: Unknown
• Excreted into animal milk: Data not available
• Because of the potential for serious adverse reactions in a breastfed child, advise a lactating woman not to breastfeed during therapy and for 1 month after the last dose.

How should this medicine be used?

Tivozanib comes as a capsule to take by mouth. It is usually taken once daily with or without food for the first 21 days of a 28-day cycle. The cycle may be repeated as recommended by your doctor. Take tivozanib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tivozanib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a glass of water; do not open them.

Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with tivozanib.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking tivozanib,

• tell your doctor and pharmacist if you are allergic to tivozanib, aspirin, tartrazine (a yellow dye in some processed foods and drugs), any other medications, or any of the ingredients in tivozanib capsules. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: apalutamide (Erleada), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), enzalutamide (Xtandi), phenytoin (Dilantin, Phenytek), and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor and pharmacist what herbal products you are taking, especially St. John’s wort. Do not take St. John’s wort while taking tivozanib.
• tell your doctor if you have an unhealed wound or if you have or have ever had a bleeding problem; a blood clot; heart failure; a heart attack; high blood pressure; seizures; or heart, thyroid, kidney or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are taking tivozanib. If you are female, you will need to have a pregnancy test before you start treatment, and you should use birth control to prevent pregnancy during your tivozanib treatment and for 1 month after your final dose. If you are male, you and your partner should use birth control to prevent pregnancy during your treatment with tivozanib and for 1 month after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. Tivozanib may decrease fertility in men and women. However, you should not assume that you or your partner cannot become pregnant. If you or your partner become pregnant while taking tivozanib, call your doctor. Tivozanib may harm the fetus.
• tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with tivozanib and for 1 month after your final dose.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tivozanib. Your doctor will probably tell you to stop taking tivozanib at least 24 days before your scheduled surgery because it can affect wound healing. Your doctor will tell you when to start taking tivozanib again after your surgery.
• you should know that tivozanib may cause high blood pressure. Your blood pressure should be checked regularly while you are taking tivozanib.

References

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