Midostaurin – Uses, Dosage, Side Effects, Interaction

Indications

• Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML) who are FLT3 mutation-positive, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL).
• Midostaurin is an antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
• Rydapt is indicated: in combination with standard daunorubicin and cytarabine induction and high dose cytarabine consolidation chemotherapy, and for patients in complete response followed by Rydapt single agent maintenance therapy, for adult patients with newly diagnosed acute myeloid leukemia (AML) who are FLT3 mutation-positive as monotherapy for the treatment of adult patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM AHN), or mast cell leukemia (MCL).
• Midostaurin is an orally available small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) which is used as an antineoplastic agent in the treatment of acute myeloid leukemia with FLT3 mutations.
• In combination with standard cytarabine and daunorubicin induction and cytarabine consolidation
  chemotherapy, for the treatment of adult patients with newly diagnosed acute myeloid leukemia (AML) who are FLT3
  mutation-positive, as detected by an FDA-approved test.
• Acute Myeloid Leukemia
• Aggressive Systemic Mastocytosis
• Mast Cell Leukemia (MCL)
• Systemic Mastocytosis

Use in Cancer

Midostaurin is approved to treat:

• Acute myeloid leukemia (AML). It is used with cytarabine and daunorubicin hydrochloride in newly diagnosed adults whose cancer has a mutation in the FLT3 gene.
• Aggressive systemic mastocytosis, systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia in adults.

Midostaurin is also being studied in the treatment of other conditions and types of cancer.

Contraindications

• abnormal EKG with QT changes from birth
• pregnancy
• a patient who is producing milk and breastfeeding
• lung tissue problem

Dosage

Strengths: 25 mg

Acute Myeloid Leukemia

• 50 mg orally twice a day at approximately 12-hour intervals on Days 8 to 21 of each cycle of induction AND on Days 8 to 21 of each cycle of consolidation.
• This drug is not indicated as single-agent induction therapy for acute myeloid leukemia (AML) patients.
• Information on FDA-approved tests for the detection of FLT3 mutation in AML is available at: http://www.fda.gov/CompanionDiagnostics

Systemic Mastocytosis

• 100 mg orally twice a day at approximately 12-hour intervals
• Monitor for toxicity at least weekly for the first 4 weeks, every other week for the next 8 weeks, and monthly thereafter while on treatment.
• Treatment should be continued until the disease progresses or has unacceptable toxicity.
• For the treatment of adult patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL)

Leukemia

• 100 mg orally twice a day at approximately 12-hour intervals
• Monitor for toxicity at least weekly for the first 4 weeks, every other week for the next 8 weeks, and monthly thereafter while on treatment.
• Treatment should be continued until the disease progresses or has unacceptable toxicity.
• For the treatment of adult patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL)

Dose Adjustments

FOR PATIENTS WITH SYSTEMIC MASTOCYTOSIS:

ABSOLUTE NEUTROPHIL COUNT (ANC) LESS THAN 1 x 10(9)/L WITHOUT MCL OR ANC LESS THAN 0.5 x 10(9)/L WITH BASELINE ANC VALUE of 0.5 to 1.5 x 10(9)/L:

• Interrupt treatment until ANC 1 x 10(9)/L or greater, then resume treatment at 50 mg twice a day; increase to 100 mg twice a day if tolerated.
• Discontinue treatment if low ANC persists for more than 21 days and is suspected to be drug-related.

PLATELET COUNT LESS THAN 50 X 10(9)/L WITHOUT MCL OR PLATELET COUNT LESS THAN 25 x 10(9)/L WITH BASELINE PLATELET COUNT of 25 to 75 x 10(9)/L:

• Interrupt treatment until platelet count 50 x 10(9)/L or greater, then resume treatment at 50 mg twice a day; increase to 100 mg twice a day if tolerated.
• Discontinue treatment if low platelet count persists for more than 21 days and is suspected to be drug-related.

HEMOGLOBIN LESS THAN 8 g/L WITHOUT MCL OR LIFE-THREATENING ANEMIA WITH BASELINE HEMOGLOBIN VALUE of 8 to 10 g/L:

• Interrupt treatment until hemoglobin 8 g/L or greater, then resume treatment at 50 mg twice a day; increase to 100 mg twice a day if tolerated.
• Discontinue treatment if low hemoglobin persists for more than 21 days and is suspected to be drug-related.

GRADE 3/4 NAUSEA AND/OR VOMITING DESPITE OPTIMAL ANTI-EMETIC THERAPY: Interrupt treatment for 3 days (6 doses), then resume treatment at 50 mg twice a day; increase to 100 mg twice a day if tolerated.

OTHER GRADE 3/4 NON-HEMATOLOGICAL TOXICITIES: Interrupt treatment until the event has resolved to Grade 2 or less, then resume treatment at 50 mg twice a day; increase to 100 mg twice a day if tolerated.

Side Effects

The Most Common

• nausea
• vomiting
• diarrhea
• headache
• nosebleeds
• tiredness
• weakness
• dizziness
• constipation
• hemorrhoids
• increased sweating
• stomach pain
• white patches or sores on the lips or in the mouth and throat
• swelling of the hands, feet, ankles, or lower legs
• back, bone, joint, limb, or muscle pain
• difficulty falling asleep or staying asleep
• fever, cough, sore throat, chills, and other signs of infection
• rapid, irregular, or pounding heartbeat
• shortness of breath
• chest pain
• flushing
• swelling of the lips, tongue, or throat
• difficulty breathing or swallowing
• hives
• rash
• itching
• new or worsening cough
• wheezing
• vomiting blood or vomiting material that looks like coffee grounds
• unusual bleeding or bruising
• burning or pain when urinating

More common

• Black, tarry stools
• bloody urine
• body aches or pain
• bone, joint, or muscle pain
• chest pain or tightness
• cough
• decreased frequency or amount of urine
• dizziness
• ear congestion
• fever or chills
• headache
• increased thirst
• loss of appetite
• loss of voice
• lower back or side pain
• nausea
• painful or difficult urination
• pale skin
• runny or stuffy nose
• sneezing
• sore throat
• stomach pain
• swelling of the face, fingers, or lower legs
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting
• weight gain

Rare

• Chills
• general feeling of discomfort or illness
• thickening of bronchial secretions
• Bloody nose
• blurred vision
• cracked lips
• diarrhea
• difficulty having a bowel movement (stool)
• difficulty with moving
• difficulty with swallowing
• dry mouth
• flushed, dry skin
• fruit-like breath odor
• headache
• increased hunger
• increased sweating
• increased thirst
• increased urination
• muscle stiffness
• small red or purple spots on the skin
• sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• sweating
• trouble sleeping
• unexplained weight loss

Drug Interactions

DRUG	INTERACTION
1,2-Benzodiazepine	The metabolism of 1,2-Benzodiazepine can be decreased when combined with Midostaurin.
Abametapir	The serum concentration of Midostaurin can be increased when it is combined with Abametapir.
Abatacept	The metabolism of Midostaurin can be increased when combined with Abatacept.
Abemaciclib	The metabolism of Abemaciclib can be decreased when combined with Midostaurin.
Abiraterone	The metabolism of Abiraterone can be increased when combined with Midostaurin.
Acalabrutinib	The metabolism of Acalabrutinib can be decreased when combined with Midostaurin.
Acenocoumarol	The metabolism of Acenocoumarol can be decreased when combined with Midostaurin.
Acetaminophen	The metabolism of Acetaminophen can be decreased when combined with Midostaurin.
Acetazolamide	The metabolism of Midostaurin can be decreased when combined with Acetazolamide.
Adagrasib	The serum concentration of Adagrasib can be decreased when it is combined with Midostaurin.
Adalimumab	The metabolism of Midostaurin can be increased when combined with Adalimumab.
Albendazole	The metabolism of Albendazole can be decreased when combined with Midostaurin.
Aldesleukin	The metabolism of Midostaurin can be decreased when combined with Aldesleukin.
Alectinib	The metabolism of Alectinib can be decreased when combined with Midostaurin.
Alfentanil	The metabolism of Alfentanil can be decreased when combined with Midostaurin.
Alfuzosin	The metabolism of Alfuzosin can be decreased when combined with Midostaurin.
Aliskiren	The metabolism of Aliskiren can be decreased when combined with Midostaurin.
Almotriptan	The metabolism of Almotriptan can be decreased when combined with Midostaurin.
Alogliptin	The metabolism of Alogliptin can be decreased when combined with Midostaurin.
Alosetron	The metabolism of Alosetron can be decreased when combined with Midostaurin.
Alpelisib	The serum concentration of Alpelisib can be decreased when it is combined with Midostaurin.
Alprazolam	The metabolism of Alprazolam can be decreased when combined with Midostaurin.
Ambrisentan	The metabolism of Ambrisentan can be decreased when combined with Midostaurin.
Ambroxol	The metabolism of Ambroxol can be decreased when combined with Midostaurin.
Aminoglutethimide	The metabolism of Midostaurin can be increased when combined with Aminoglutethimide.
Aminophenazone	The metabolism of Aminophenazone can be decreased when combined with Midostaurin.
Aminophylline	The metabolism of Aminophylline can be decreased when combined with Midostaurin.
Amiodarone	The metabolism of Midostaurin can be decreased when combined with Amiodarone.
Amitriptyline	The metabolism of Amitriptyline can be decreased when combined with Midostaurin.
Amlodipine	The metabolism of Amlodipine can be decreased when combined with Midostaurin.
Amobarbital	The metabolism of Midostaurin can be increased when combined with Amobarbital.
Amprenavir	The metabolism of Midostaurin can be decreased when combined with Amprenavir.
Anakinra	The metabolism of Midostaurin can be increased when combined with Anakinra.
Antipyrine	The metabolism of Antipyrine can be decreased when combined with Midostaurin.
Apalutamide	The metabolism of Apalutamide can be decreased when combined with Midostaurin.
Apixaban	The metabolism of Apixaban can be decreased when combined with Midostaurin.
Apomorphine	The metabolism of Apomorphine can be increased when combined with Midostaurin.
Apremilast	The metabolism of Apremilast can be decreased when combined with Midostaurin.
Aprepitant	The metabolism of Aprepitant can be decreased when combined with Midostaurin.
Aripiprazole	The metabolism of Aripiprazole can be decreased when combined with Midostaurin.
Aripiprazole lau	The serum concentration of aripiprazole, an active metabolite of Midostaurin, can be decreased when used in combination with Aripiprazole lauroxil.
Armodafinil	The metabolism of Midostaurin can be increased when combined with Armodafinil.
Artemether	The metabolism of Artemether can be decreased when combined with Midostaurin.
Articaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Articaine.
Asciminib	The serum concentration of Asciminib can be increased when it is combined with Midostaurin.
Asenapine	The metabolism of Asenapine can be decreased when combined with Midostaurin.
Astemizole	The metabolism of Astemizole can be decreased when combined with Midostaurin.
Asunaprevir	The metabolism of Asunaprevir can be decreased when combined with Midostaurin.
Atazanavir	The metabolism of Midostaurin can be decreased when combined with Atazanavir.
Atogepant	The serum concentration of Atogepant can be increased when it is combined with Midostaurin.
Atorvastatin	The metabolism of Atorvastatin can be decreased when combined with Midostaurin.
Atovaquone	The metabolism of Atovaquone can be decreased when combined with Midostaurin.
Avacopan	The metabolism of Avacopan can be decreased when combined with Midostaurin.
Avanafil	The metabolism of Avanafil can be decreased when combined with Midostaurin.
Avapritinib	The metabolism of Avapritinib can be decreased when combined with Midostaurin.
Axitinib	The metabolism of Axitinib can be decreased when combined with Midostaurin.
Azelastine	The metabolism of Azelastine can be decreased when combined with Midostaurin.
Azithromycin	The metabolism of Azithromycin can be decreased when combined with Midostaurin.
Baricitinib	The metabolism of Baricitinib can be decreased when combined with Midostaurin.
Beclomethasone	The metabolism of Beclomethasone dipropionate can be decreased when combined with Midostaurin.
Bedaquiline	The metabolism of Bedaquiline can be decreased when combined with Midostaurin.
Belumosudil	The serum concentration of Belumosudil can be decreased when it is combined with Midostaurin.
Belzutifan	The serum concentration of Midostaurin can be decreased when it is combined with Belzutifan.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Benzocaine.
Benzphetamine	The metabolism of Benzphetamine can be decreased when combined with Midostaurin.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Benzyl alcohol.
Bepridil	The metabolism of Bepridil can be decreased when combined with Midostaurin.
Berotralstat	The serum concentration of Midostaurin can be increased when it is combined with Berotralstat.
Betamethasone	The metabolism of Betamethasone can be decreased when combined with Midostaurin.
Betamethasone	The metabolism of Betamethasone phosphate can be decreased when combined with Midostaurin.
Bexarotene	The metabolism of Bexarotene can be decreased when combined with Midostaurin.
Bezafibrate	The metabolism of Bezafibrate can be decreased when combined with Midostaurin.
Bicalutamide	The metabolism of Bicalutamide can be decreased when combined with Midostaurin.
Bictegravir	The metabolism of Bictegravir can be decreased when combined with Midostaurin.
Bifonazole	The metabolism of Midostaurin can be decreased when combined with Bifonazole.
Bimekizumab	The metabolism of Midostaurin can be increased when combined with Bimekizumab.
Bisoprolol	The metabolism of Bisoprolol can be decreased when combined with Midostaurin.
Boceprevir	The metabolism of Midostaurin can be decreased when combined with Boceprevir.
Bortezomib	The metabolism of Bortezomib can be increased when combined with Midostaurin.
Bosentan	The metabolism of Bosentan can be decreased when combined with Midostaurin.
Bosutinib	The metabolism of Bosutinib can be decreased when combined with Midostaurin.
Brentuximab vedo	The metabolism of Brentuximab vedotin can be decreased when combined with Midostaurin.
Brexpiprazole	The metabolism of Brexpiprazole can be decreased when combined with Midostaurin.
Brigatinib	The metabolism of Brigatinib can be decreased when combined with Midostaurin.
Brivaracetam	The metabolism of Brivaracetam can be decreased when combined with Midostaurin.
Bromocriptine	The serum concentration of Bromocriptine can be increased when it is combined with Midostaurin.
Budesonide	The metabolism of Budesonide can be decreased when combined with Midostaurin.
Bupivacaine	The metabolism of Bupivacaine can be decreased when combined with Midostaurin.
Buprenorphine	The metabolism of Buprenorphine can be decreased when combined with Midostaurin.
Buspirone	The metabolism of Buspirone can be decreased when combined with Midostaurin.
Busulfan	The metabolism of Busulfan can be decreased when combined with Midostaurin.
Butacaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Butacaine.
Butalbital	The metabolism of Midostaurin can be increased when combined with Butalbital.
Butamben	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Butamben.
Cabazitaxel	The metabolism of Cabazitaxel can be decreased when combined with Midostaurin.
Cabergoline	The metabolism of Cabergoline can be decreased when combined with Midostaurin.
Cabozantinib	The metabolism of Cabozantinib can be decreased when combined with Midostaurin.
Calcitriol	The metabolism of Calcitriol can be decreased when combined with Midostaurin.
Canagliflozin	The metabolism of Canagliflozin can be decreased when combined with Midostaurin.
Canakinumab	The metabolism of Midostaurin can be increased when combined with Canakinumab.

Candicidin	The metabolism of Midostaurin can be decreased when combined with Candicidin.
Cannabidiol	The metabolism of Cannabidiol can be decreased when combined with Midostaurin.
Capmatinib	The serum concentration of Capmatinib can be decreased when it is combined with Midostaurin.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Capsaicin.
Carbamazepine	The metabolism of Carbamazepine can be decreased when combined with Midostaurin.
Carbimazole	The therapeutic efficacy of Carbimazole can be decreased when used in combination with Midostaurin.
Cariprazine	The metabolism of Cariprazine can be decreased when combined with Midostaurin.
Carvedilol	The metabolism of Carvedilol can be decreased when combined with Midostaurin.
Cefradine	The metabolism of Midostaurin can be increased when combined with Cefradine.
Celecoxib	The metabolism of Celecoxib can be decreased when combined with Midostaurin.
Cenobamate	The serum concentration of Midostaurin can be decreased when it is combined with Cenobamate.
Cephalexin	The metabolism of Cephalexin can be decreased when combined with Midostaurin.
Ceritinib	The metabolism of Ceritinib can be decreased when combined with Midostaurin.
Cerivastatin	The metabolism of Cerivastatin can be decreased when combined with Midostaurin.
Certolizumab	The metabolism of Midostaurin can be increased when combined with Certolizumab pegol.
Cevimeline	The metabolism of Cevimeline can be decreased when combined with Midostaurin.
Chenodeoxycholic	The metabolism of Chenodeoxycholic acid can be decreased when combined with Midostaurin.
Chloramphenicol	The metabolism of Midostaurin can be decreased when combined with Chloramphenicol.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Chloroprocaine.
Chloroquine	The metabolism of Chloroquine can be decreased when combined with Midostaurin.
Chlorpheniramine	The metabolism of Chlorpheniramine can be decreased when combined with Midostaurin.
Chlorpromazine	The metabolism of Chlorpromazine can be decreased when combined with Midostaurin.
Chlorzoxazone	The metabolism of Chlorzoxazone can be decreased when combined with Midostaurin.
Cholecalciferol	The metabolism of Cholecalciferol can be decreased when combined with Midostaurin.
Ciclesonide	The metabolism of Ciclesonide can be decreased when combined with Midostaurin.
Cilostazol	The metabolism of Cilostazol can be decreased when combined with Midostaurin.
Cimetidine	The metabolism of Midostaurin can be decreased when combined with Cimetidine.
Cinacalcet	The metabolism of Cinacalcet can be decreased when combined with Midostaurin.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Cinchocaine.
Cinnarizine	The metabolism of Cinnarizine can be decreased when combined with Midostaurin.
Ciprofloxacin	The metabolism of Midostaurin can be decreased when combined with Ciprofloxacin.
Cisapride	The metabolism of Cisapride can be decreased when combined with Midostaurin.
Citalopram	The metabolism of Citalopram can be decreased when combined with Midostaurin.
Clarithromycin	The metabolism of Midostaurin can be decreased when combined with Clarithromycin.
Clevidipine	The metabolism of Clevidipine can be decreased when combined with Midostaurin.
Clindamycin	The metabolism of Clindamycin can be increased when combined with Midostaurin.
Clobazam	The metabolism of Clobazam can be decreased when combined with Midostaurin.
Clobetasol prop	The metabolism of Clobetasol propionate can be decreased when combined with Midostaurin.
Clofazimine	The metabolism of Midostaurin can be decreased when combined with Clofazimine.
Clofibrate	The metabolism of Clofibrate can be decreased when combined with Midostaurin.
Clomipramine	The metabolism of Clomipramine can be decreased when combined with Midostaurin.
Clonazepam	The metabolism of Clonazepam can be increased when combined with Midostaurin.
Clonidine	The metabolism of Clonidine can be decreased when combined with Midostaurin.
Clopidogrel	The metabolism of Clopidogrel can be decreased when combined with Midostaurin.
Clorazepic acid	The metabolism of Clorazepic acid can be decreased when combined with Midostaurin.
Clotiazepam	The metabolism of Clotiazepam can be decreased when combined with Midostaurin.
Clozapine	The serum concentration of Clozapine can be increased when it is combined with Midostaurin.
Cobicistat	The metabolism of Midostaurin can be decreased when combined with Cobicistat.
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Midostaurin.
Cocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Cocaine.
Codeine	The metabolism of Codeine can be decreased when combined with Midostaurin.
Colchicine	The metabolism of Colchicine can be decreased when combined with Midostaurin.
Conivaptan	The metabolism of Midostaurin can be decreased when combined with Conivaptan.
Conju estrogens	The metabolism of Conjugated estrogens can be decreased when combined with Midostaurin.
Copanlisib	The metabolism of Copanlisib can be decreased when combined with Midostaurin.
Corticotropin	The metabolism of Corticotropin can be decreased when combined with Midostaurin.
Cortisone acetate	The metabolism of Cortisone acetate can be decreased when combined with Midostaurin.
Crizotinib	The metabolism of Midostaurin can be decreased when combined with Crizotinib.
Curcumin	The metabolism of Midostaurin can be decreased when combined with Curcumin.
Cyclandelate	The metabolism of Cyclandelate can be decreased when combined with Midostaurin.
Cyclobenzaprine	The metabolism of Cyclobenzaprine can be decreased when combined with Midostaurin.
Cyclophosphamide	The metabolism of Cyclophosphamide can be decreased when combined with Midostaurin.
Cyclosporine	The metabolism of Cyclosporine can be decreased when combined with Midostaurin.
Cyproterone acetate	The metabolism of Cyproterone acetate can be decreased when combined with Midostaurin.
Dabrafenib	The serum concentration of Dabrafenib can be increased when it is combined with Midostaurin.
Daclatasvir	The metabolism of Daclatasvir can be decreased when combined with Midostaurin.
Dacomitinib	The metabolism of Dacomitinib can be decreased when combined with Midostaurin.
Dalfopristin	The metabolism of Midostaurin can be decreased when combined with Dalfopristin.
Danazol	The metabolism of Midostaurin can be decreased when combined with Danazol.
Dapagliflozin	The metabolism of Dapagliflozin can be decreased when combined with Midostaurin.
Dapsone	The metabolism of Dapsone can be decreased when combined with Midostaurin.
Darbepoetin alfa	The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Midostaurin.
Daridorexant	The metabolism of Daridorexant can be decreased when combined with Midostaurin.
Darifenacin	The metabolism of Darifenacin can be decreased when combined with Midostaurin.
Darolutamide	The serum concentration of Darolutamide can be decreased when it is combined with Midostaurin.
Darunavir	The serum concentration of Midostaurin can be increased when it is combined with Darunavir.
Dasabuvir	The metabolism of Dasabuvir can be decreased when combined with Midostaurin.
Dasatinib	The therapeutic efficacy of Dasatinib can be decreased when used in combination with Midostaurin.
Daunorubicin	The metabolism of Midostaurin can be decreased when combined with Daunorubicin.
Deferasirox	The metabolism of Midostaurin can be increased when combined with Deferasirox.
Deflazacort	The serum concentration of Deflazacort can be decreased when it is combined with Midostaurin.
Delamanid	The metabolism of Delamanid can be decreased when combined with Midostaurin.
Delavirdine	The metabolism of Midostaurin can be decreased when combined with Delavirdine.
Desipramine	The metabolism of Midostaurin can be decreased when combined with Desipramine.
Desogestrel	The metabolism of Desogestrel can be decreased when combined with Midostaurin.
Desoxycorticoster	The metabolism of Desoxycorticosterone acetate can be decreased when combined with Midostaurin.
Desvenlafaxine	The metabolism of Desvenlafaxine can be decreased when combined with Midostaurin.
Deutetrabenazine	The metabolism of Deutetrabenazine can be decreased when combined with Midostaurin.
Dexamethasone	The metabolism of Dexamethasone can be decreased when combined with Midostaurin.
Dexamethasone	The metabolism of Dexamethasone acetate can be decreased when combined with Midostaurin.
Dexchlorpheniramine	The metabolism of Dexchlorpheniramine maleate can be decreased when combined with Midostaurin.
Dexlansoprazole	The metabolism of Dexlansoprazole can be decreased when combined with Midostaurin.
Dextromethorphan	The metabolism of Dextromethorphan can be decreased when combined with Midostaurin.
Dextropropoxyphene	The metabolism of Dextropropoxyphene can be decreased when combined with Midostaurin.
Diazepam	The metabolism of Diazepam can be decreased when combined with Midostaurin.
Diclofenac	The metabolism of Diclofenac can be decreased when combined with Midostaurin.
Dicloxacillin	The metabolism of Midostaurin can be increased when combined with Dicloxacillin.
Dienogest	The metabolism of Dienogest can be increased when combined with Midostaurin.
Diethylstilbestrol	The metabolism of Diethylstilbestrol can be decreased when combined with Midostaurin.
Difluocortolone	The metabolism of Difluocortolone can be decreased when combined with Midostaurin.

Digitoxin	The metabolism of Digitoxin can be decreased when combined with Midostaurin.
Dihy ergocryptine	The metabolism of Dihydro-alpha-ergocryptine can be decreased when combined with Midostaurin.
Dihydrocodeine	The metabolism of Dihydrocodeine can be decreased when combined with Midostaurin.
Dihydroergocornine	The serum concentration of Dihydroergocornine can be increased when it is combined with Midostaurin.
Dihydroergocristine	The serum concentration of Dihydroergocristine can be increased when it is combined with Midostaurin.
Dihydroergotamine	The metabolism of Dihydroergotamine can be decreased when combined with Midostaurin.
Diltiazem	The metabolism of Diltiazem can be decreased when combined with Midostaurin.
Dimethyl sulfoxide	The metabolism of Midostaurin can be decreased when combined with Dimethyl sulfoxide.
Diosmin	The metabolism of Midostaurin can be decreased when combined with Diosmin.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Diphenhydramine.
Disopyramide	The metabolism of Disopyramide can be decreased when combined with Midostaurin.
Disulfiram	The metabolism of Disulfiram can be decreased when combined with Midostaurin.
Docetaxel	The metabolism of Docetaxel can be decreased when combined with Midostaurin.
Dofetilide	The metabolism of Dofetilide can be decreased when combined with Midostaurin.
Dolasetron	The metabolism of Dolasetron can be decreased when combined with Midostaurin.
Domperidone	The metabolism of Domperidone can be decreased when combined with Midostaurin.
Donepezil	The metabolism of Donepezil can be decreased when combined with Midostaurin.
Doravirine	The metabolism of Doravirine can be decreased when combined with Midostaurin.
Doxazosin	The metabolism of Doxazosin can be decreased when combined with Midostaurin.
Doxepin	The metabolism of Doxepin can be decreased when combined with Midostaurin.
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Midostaurin.
Dronabinol	The serum concentration of Dronabinol can be increased when it is combined with Midostaurin.
Dronedarone	The metabolism of Dronedarone can be decreased when combined with Midostaurin.
Drospirenone	The metabolism of Drospirenone can be decreased when combined with Midostaurin.
Dutasteride	The metabolism of Dutasteride can be increased when combined with Midostaurin.
Duvelisib	The metabolism of Duvelisib can be decreased when combined with Midostaurin.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Dyclonine.
Dydrogesterone	The metabolism of Dydrogesterone can be decreased when combined with Midostaurin.
Ebastine	The metabolism of Ebastine can be decreased when combined with Midostaurin.
Echinacea	The metabolism of Midostaurin can be increased when combined with Echinacea.
Efavirenz	The metabolism of Midostaurin can be decreased when combined with Efavirenz.
Elacestrant	The serum concentration of Elacestrant can be increased when it is combined with Midostaurin.
Elbasvir	The metabolism of Elbasvir can be decreased when combined with Midostaurin.
Eletriptan	The metabolism of Eletriptan can be decreased when combined with Midostaurin.
Elexacaftor	The serum concentration of Elexacaftor can be decreased when it is combined with Midostaurin.
Eliglustat	The metabolism of Eliglustat can be decreased when combined with Midostaurin.
Elvitegravir	The metabolism of Midostaurin can be decreased when combined with Elvitegravir.
Emapalumab	The metabolism of Midostaurin can be increased when combined with Emapalumab.
Enasidenib	The metabolism of Enasidenib can be decreased when combined with Midostaurin.
Encorafenib	The metabolism of Encorafenib can be decreased when combined with Midostaurin.
Enfortumab ved	The serum concentration of Enfortumab vedotin can be increased when it is combined with Midostaurin.
Entrectinib	The metabolism of Entrectinib can be increased when combined with Midostaurin.
Enzalutamide	The serum concentration of Midostaurin can be decreased when it is combined with Enzalutamide.
Epinastine	The metabolism of Epinastine can be decreased when combined with Midostaurin.
Epinephrine	The metabolism of Midostaurin can be decreased when combined with Epinephrine.
Eplerenone	The metabolism of Eplerenone can be decreased when combined with Midostaurin.
Eravacycline	The metabolism of Eravacycline can be decreased when combined with Midostaurin.
Erdafitinib	The metabolism of Erdafitinib can be decreased when combined with Midostaurin.
Ergoloid mesylate	The serum concentration of Ergoloid mesylate can be increased when it is combined with Midostaurin.
Ergometrine	The serum concentration of Ergometrine can be increased when it is combined with Midostaurin.
Ergotamine	The metabolism of Midostaurin can be decreased when combined with Ergotamine.
Erlotinib	The metabolism of Erlotinib can be decreased when combined with Midostaurin.
Erythromycin	The metabolism of Erythromycin can be decreased when combined with Midostaurin.
Erythropoietin	The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Midostaurin.
Escitalopram	The metabolism of Escitalopram can be decreased when combined with Midostaurin.
Esketamine	The metabolism of Esketamine can be decreased when combined with Midostaurin.
Eslicarbazepine	The metabolism of Midostaurin can be increased when combined with Eslicarbazepine.
Eslicarbazepine	The metabolism of Midostaurin can be increased when combined with Eslicarbazepine acetate.
Esomeprazole	The metabolism of Esomeprazole can be decreased when combined with Midostaurin.
Estazolam	The metabolism of Estazolam can be decreased when combined with Midostaurin.
Esterified estrogens	The metabolism of Esterified estrogens can be decreased when combined with Midostaurin.
Estetrol	The metabolism of Estetrol can be decreased when combined with Midostaurin.
Estradiol	The metabolism of Estradiol can be decreased when combined with Midostaurin.
Estradiol acetate	The metabolism of Estradiol acetate can be decreased when combined with Midostaurin.
Estradiol benzoate	The metabolism of Estradiol benzoate can be decreased when combined with Midostaurin.
Estradiol cypionate	The metabolism of Estradiol cypionate can be decreased when combined with Midostaurin.
Estradiol diena	The metabolism of Estradiol dienanthate can be decreased when combined with Midostaurin.
Estradiol valerate	The metabolism of Estradiol valerate can be decreased when combined with Midostaurin.
Estramustine	The metabolism of Estramustine can be decreased when combined with Midostaurin.
Estrone sulfate	The metabolism of Estrone sulfate can be decreased when combined with Midostaurin.
Eszopiclone	The serum concentration of Eszopiclone can be increased when it is combined with Midostaurin.
Etanercept	The metabolism of Midostaurin can be increased when combined with Etanercept.
Ethambutol	The metabolism of Midostaurin can be decreased when combined with Ethambutol.
Ethanol	The metabolism of Ethanol can be decreased when combined with Midostaurin.
Ethinylestradiol	The metabolism of Ethinylestradiol can be decreased when combined with Midostaurin.
Ethosuximide	The metabolism of Ethosuximide can be decreased when combined with Midostaurin.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Ethyl chloride.
Ethynodiol diac	The metabolism of Ethynodiol diacetate can be decreased when combined with Midostaurin.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Etidocaine.
Etonogestrel	The metabolism of Etonogestrel can be decreased when combined with Midostaurin.
Etoposide	The metabolism of Etoposide can be decreased when combined with Midostaurin.
Etoricoxib	The metabolism of Etoricoxib can be decreased when combined with Midostaurin.
Etravirine	The metabolism of Etravirine can be decreased when combined with Midostaurin.
Everolimus	The metabolism of Everolimus can be increased when combined with Midostaurin.
Exemestane	The metabolism of Exemestane can be increased when combined with Midostaurin.
Fedratinib	The metabolism of Fedratinib can be decreased when combined with Midostaurin.
Felbamate	The metabolism of Felbamate can be decreased when combined with Midostaurin.
Felodipine	The metabolism of Felodipine can be decreased when combined with Midostaurin.
Fenofibrate	The metabolism of Fenofibrate can be decreased when combined with Midostaurin.
Fentanyl	The metabolism of Fentanyl can be decreased when combined with Midostaurin.
Fesoterodine	The metabolism of Fesoterodine can be decreased when combined with Midostaurin.
Fexinidazole	The metabolism of Fexinidazole can be decreased when combined with Midostaurin.
Finasteride	The metabolism of Finasteride can be decreased when combined with Midostaurin.
Finerenone	The serum concentration of the active metabolites of Finerenone can be increased when Finerenone is used in combination with Midostaurin.
Fish oil	The metabolism of Fish oil can be decreased when combined with Midostaurin.
Flibanserin	The metabolism of Flibanserin can be decreased when combined with Midostaurin.
Flucloxacillin	The metabolism of Midostaurin can be increased when combined with Flucloxacillin.
Fluconazole	The metabolism of Midostaurin can be decreased when combined with Fluconazole.
Fludrocortisone	The metabolism of Fludrocortisone can be decreased when combined with Midostaurin.
Flumethasone	The metabolism of Flumethasone can be decreased when combined with Midostaurin.

Flunarizine	The metabolism of Flunarizine can be decreased when combined with Midostaurin.
Flunisolide	The metabolism of Flunisolide can be decreased when combined with Midostaurin.
Flunitrazepam	The metabolism of Flunitrazepam can be decreased when combined with Midostaurin.
Fluocinolone	The metabolism of Fluocinolone acetonide can be decreased when combined with Midostaurin.
Fluocinonide	The metabolism of Fluocinonide can be decreased when combined with Midostaurin.
Fluocortolone	The metabolism of Fluocortolone can be decreased when combined with Midostaurin.
Fluoxetine	The metabolism of Midostaurin can be decreased when combined with Fluoxetine.
Fluprednisolone	The metabolism of Fluprednisolone can be decreased when combined with Midostaurin.
Flurazepam	The metabolism of Flurazepam can be decreased when combined with Midostaurin.
Fluspirilene	The metabolism of Fluspirilene can be decreased when combined with Midostaurin.
Flutamide	The metabolism of Flutamide can be decreased when combined with Midostaurin.
Fluticasone	The metabolism of Midostaurin can be increased when combined with Fluticasone.
Fluticasone fu	The metabolism of Fluticasone furoate can be decreased when combined with Midostaurin.
Fluticasone pr	The serum concentration of Fluticasone propionate can be increased when it is combined with Midostaurin.
Fluvastatin	The metabolism of Fluvastatin can be decreased when combined with Midostaurin.
Fluvoxamine	The metabolism of Fluvoxamine can be decreased when combined with Midostaurin.
Follitropin	The therapeutic efficacy of Follitropin can be decreased when used in combination with Midostaurin.
Formestane	The metabolism of Midostaurin can be increased when combined with Formestane.
Fosamprenavir	The metabolism of Fosamprenavir can be decreased when combined with Midostaurin.
Fosaprepitant	The metabolism of Fosaprepitant can be decreased when combined with Midostaurin.
Fosnetupitant	The metabolism of Fosnetupitant can be decreased when combined with Midostaurin.
Fosphenytoin	The metabolism of Fosphenytoin can be decreased when combined with Midostaurin.
Fostamatinib	The metabolism of Fostamatinib can be decreased when combined with Midostaurin.
Fostemsavir	The serum concentration of Fostemsavir can be decreased when it is combined with Midostaurin.
Fusidic acid	The metabolism of Fusidic acid can be decreased when combined with Midostaurin.
Futibatinib	The metabolism of Futibatinib can be decreased when combined with Midostaurin.
Galantamine	The metabolism of Galantamine can be decreased when combined with Midostaurin.
Ganaxolone	The metabolism of Ganaxolone can be increased when combined with Midostaurin.
Gefitinib	The metabolism of Gefitinib can be increased when combined with Midostaurin.
Gemfibrozil	The metabolism of Gemfibrozil can be decreased when combined with Midostaurin.
Gestrinone	The metabolism of Gestrinone can be decreased when combined with Midostaurin.
Gilteritinib	The metabolism of Gilteritinib can be decreased when combined with Midostaurin.
Ginkgo biloba	The metabolism of Midostaurin can be decreased when combined with Ginkgo biloba.
Glasdegib	The serum concentration of Glasdegib can be increased when it is combined with Midostaurin.
Glecaprevir	The metabolism of Midostaurin can be decreased when combined with Glecaprevir.
Glyburide	The metabolism of Glyburide can be decreased when combined with Midostaurin.
Glycerol phen	The metabolism of Midostaurin can be increased when combined with Glycerol phenylbutyrate.
Golimumab	The metabolism of Midostaurin can be increased when combined with Golimumab.
Granisetron	The metabolism of Granisetron can be decreased when combined with Midostaurin.
Grapefruit	The metabolism of Midostaurin can be decreased when combined with Grapefruit.
Grazoprevir	The metabolism of Grazoprevir can be decreased when combined with Midostaurin.
Grepafloxacin	The metabolism of Grepafloxacin can be decreased when combined with Midostaurin.
Griseofulvin	The metabolism of Midostaurin can be increased when combined with Griseofulvin.
Guanfacine	The metabolism of Guanfacine can be decreased when combined with Midostaurin.
Halofantrine	The metabolism of Halofantrine can be decreased when combined with Midostaurin.
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Midostaurin.
Hydralazine	The metabolism of Midostaurin can be decreased when combined with Hydralazine.
Hydrocodone	The metabolism of Hydrocodone can be increased when combined with Midostaurin.
Hydrocortamate	The metabolism of Midostaurin can be increased when combined with Hydrocortamate.
Hydrocortisone	The metabolism of Hydrocortisone can be decreased when combined with Midostaurin.
Hydrocortisone ace	The metabolism of Hydrocortisone acetate can be decreased when combined with Midostaurin.
Hydrocortisone buty	The metabolism of Hydrocortisone butyrate can be decreased when combined with Midostaurin.
Hydrocortisone cypi	The metabolism of Hydrocortisone cypionate can be decreased when combined with Midostaurin.
Hydrocortisone pho	The metabolism of Hydrocortisone phosphate can be decreased when combined with Midostaurin.
Hydrocortisone succi	The metabolism of Hydrocortisone succinate can be decreased when combined with Midostaurin.
Hydroxychloroquine	The metabolism of Hydroxychloroquine can be decreased when combined with Midostaurin.
Hydroxyprogesterone	The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Midostaurin.
Hydroxyzine	The metabolism of Hydroxyzine can be decreased when combined with Midostaurin.
Ibrexafungerp	The serum concentration of Ibrexafungerp can be decreased when it is combined with Midostaurin.
Ibrutinib	The metabolism of Ibrutinib can be decreased when combined with Midostaurin.
Ibuprofen	The metabolism of Ibuprofen can be decreased when combined with Midostaurin.
Idelalisib	The metabolism of Idelalisib can be decreased when combined with Midostaurin.
Ifosfamide	The metabolism of Ifosfamide can be increased when combined with Midostaurin.
Iloperidone	The metabolism of Iloperidone can be decreased when combined with Midostaurin.
Imatinib	The metabolism of Imatinib can be increased when combined with Midostaurin.
Imipramine	The metabolism of Imipramine can be decreased when combined with Midostaurin.
Indacaterol	The metabolism of Indacaterol can be decreased when combined with Midostaurin.
Indapamide	The metabolism of Indapamide can be decreased when combined with Midostaurin.
Indinavir	The metabolism of Midostaurin can be decreased when combined with Indinavir.
Infigratinib	The metabolism of Infigratinib can be decreased when combined with Midostaurin.
Infliximab	The metabolism of Midostaurin can be increased when combined with Infliximab.
Ipecac	The metabolism of Ipecac can be decreased when combined with Midostaurin.
Irbesartan	The metabolism of Midostaurin can be decreased when combined with Irbesartan.
Irinotecan	The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Midostaurin.
Isavuconazole	The metabolism of Isavuconazole can be decreased when combined with Midostaurin.
Isavuconazonium	The metabolism of Isavuconazonium can be decreased when combined with Midostaurin.
Isoniazid	The metabolism of Midostaurin can be decreased when combined with Isoniazid.
Isotretinoin	The metabolism of Isotretinoin can be decreased when combined with Midostaurin.
Isradipine	The metabolism of Isradipine can be decreased when combined with Midostaurin.
Istradefylline	The metabolism of Istradefylline can be decreased when combined with Midostaurin.
Itraconazole	The metabolism of Midostaurin can be decreased when combined with Itraconazole.
Ivabradine	The metabolism of Ivabradine can be decreased when combined with Midostaurin.
Ivacaftor	The serum concentration of Ivacaftor can be decreased when it is combined with Midostaurin.
Ivermectin	The metabolism of Ivermectin can be decreased when combined with Midostaurin.
Ivosidenib	The metabolism of Ivosidenib can be increased when combined with Midostaurin.
Ixabepilone	The metabolism of Ixabepilone can be increased when combined with Midostaurin.
Ixazomib	The metabolism of Ixazomib can be decreased when combined with Midostaurin.
Ketamine	The metabolism of Ketamine can be decreased when combined with Midostaurin.
Ketazolam	The metabolism of Ketazolam can be decreased when combined with Midostaurin.
Ketoconazole	The metabolism of Midostaurin can be decreased when combined with Ketoconazole.
Lacidipine	The metabolism of Lacidipine can be decreased when combined with Midostaurin.
Lacosamide	The metabolism of Lacosamide can be decreased when combined with Midostaurin.
Lanreotide	The metabolism of Midostaurin can be decreased when combined with Lanreotide.
Lansoprazole	The metabolism of Lansoprazole can be decreased when combined with Midostaurin.
Lapatinib	The metabolism of Lapatinib can be decreased when combined with Midostaurin.
Larotrectinib	The metabolism of Larotrectinib can be decreased when combined with Midostaurin.
Lefamulin	The serum concentration of Lefamulin can be increased when it is combined with Midostaurin.
Lemborexant	The serum concentration of Lemborexant can be decreased when it is combined with Midostaurin.
Lercanidipine	The metabolism of Lercanidipine can be decreased when combined with Midostaurin.
Lesinurad	The metabolism of Midostaurin can be increased when combined with Lesinurad.

Letermovir	The metabolism of Midostaurin can be decreased when combined with Letermovir.
Letrozole	The metabolism of Letrozole can be decreased when combined with Midostaurin.
Levacetylmethadol	The metabolism of Levacetylmethadol can be decreased when combined with Midostaurin.
Levamlodipine	The serum concentration of Levamlodipine can be increased when it is combined with Midostaurin.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Levobupivacaine.
Levocetirizine	The metabolism of Levocetirizine can be decreased when combined with Midostaurin.
Levoketoconazole	The metabolism of Midostaurin can be decreased when combined with Levoketoconazole.
Levomenthol	The metabolism of Levomenthol can be decreased when combined with Midostaurin.
Levomilnacipran	The metabolism of Levomilnacipran can be decreased when combined with Midostaurin.
Levonorgestrel	The metabolism of Levonorgestrel can be decreased when combined with Midostaurin.
Levothyroxine	The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Midostaurin.
Lidocaine	The metabolism of Lidocaine can be decreased when combined with Midostaurin.
Lidoflazine	The metabolism of Lidoflazine can be decreased when combined with Midostaurin.
Linagliptin	The metabolism of Linagliptin can be decreased when combined with Midostaurin.
Liothyronine	The therapeutic efficacy of Liothyronine can be decreased when used in combination with Midostaurin.
Liotrix	The metabolism of Liotrix can be decreased when combined with Midostaurin.
Lisuride	The serum concentration of Lisuride can be increased when it is combined with Midostaurin.
Lomitapide	The metabolism of Lomitapide can be decreased when combined with Midostaurin.
Lonafarnib	The metabolism of Midostaurin can be decreased when combined with Lonafarnib.
Loperamide	The metabolism of Loperamide can be decreased when combined with Midostaurin.
Lopinavir	The metabolism of Midostaurin can be decreased when combined with Lopinavir.
Loratadine	The metabolism of Loratadine can be decreased when combined with Midostaurin.
Lorazepam	The metabolism of Lorazepam can be decreased when combined with Midostaurin.
Lorcaserin	The metabolism of Lorcaserin can be decreased when combined with Midostaurin.
Lorlatinib	The metabolism of Lorlatinib can be decreased when combined with Midostaurin.
Lorpiprazole	The metabolism of Lorpiprazole can be decreased when combined with Midostaurin.
Losartan	The metabolism of Losartan can be decreased when combined with Midostaurin.
Lovastatin	The serum concentration of Lovastatin can be increased when it is combined with Midostaurin.
Lumacaftor	The serum concentration of Lumacaftor can be increased when it is combined with Midostaurin.
Lumateperone	The serum concentration of Lumateperone can be decreased when it is combined with Midostaurin.
Lumefantrine	The metabolism of Lumefantrine can be decreased when combined with Midostaurin.
Lurasidone	The metabolism of Lurasidone can be decreased when combined with Midostaurin.
Lurbinectedin	The serum concentration of Lurbinectedin can be decreased when it is combined with Midostaurin.
Lynestrenol	The metabolism of Lynestrenol can be decreased when combined with Midostaurin.
Macimorelin	The metabolism of Macimorelin can be decreased when combined with Midostaurin.
Macitentan	The metabolism of Macitentan can be decreased when combined with Midostaurin.
Manidipine	The metabolism of Manidipine can be decreased when combined with Midostaurin.
Maraviroc	The metabolism of Maraviroc can be decreased when combined with Midostaurin.
Maribavir	The serum concentration of Maribavir can be decreased when it is combined with Midostaurin.
Mavacamten	The serum concentration of Mavacamten can be increased when it is combined with Midostaurin.
Medrogestone	The metabolism of Medrogestone can be decreased when combined with Midostaurin.
Medroxyprogestero	The metabolism of Medroxyprogesterone acetate can be decreased when combined with Midostaurin.
Mefloquine	The metabolism of Mefloquine can be decreased when combined with Midostaurin.
Megestrol acetate	The metabolism of Megestrol acetate can be decreased when combined with Midostaurin.
Meloxicam	The metabolism of Meloxicam can be decreased when combined with Midostaurin.
Meperidine	The metabolism of Meperidine can be decreased when combined with Midostaurin.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Mepivacaine.
Meprednisone	The metabolism of Meprednisone can be decreased when combined with Midostaurin.
Mestranol	The metabolism of Mestranol can be decreased when combined with Midostaurin.
Metergoline	The serum concentration of Metergoline can be increased when it is combined with Midostaurin.
Methadone	The metabolism of Methadone can be decreased when combined with Midostaurin.
Methimazole	The metabolism of Midostaurin can be decreased when combined with Methimazole.
Methotrexate	The metabolism of Methotrexate can be decreased when combined with Midostaurin.
Methoxy polyeth	The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Midostaurin.
Methylene blue	The metabolism of Midostaurin can be decreased when combined with Methylene blue.
Methylergometrine	The serum concentration of Methylergometrine can be increased when it is combined with Midostaurin.
Methylphenobarbital	The metabolism of Midostaurin can be increased when combined with Methylphenobarbital.
Methylprednisolone	The metabolism of Methylprednisolone can be decreased when combined with Midostaurin.
Methylprednisone	The metabolism of Methylprednisone can be decreased when combined with Midostaurin.
Methyltestosterone	The metabolism of Methyltestosterone can be decreased when combined with Midostaurin.
Methysergide	The serum concentration of Methysergide can be increased when it is combined with Midostaurin.
Metoclopramide	The metabolism of Metoclopramide can be decreased when combined with Midostaurin.
Metreleptin	The metabolism of Midostaurin can be increased when combined with Metreleptin.
Metronidazole	The metabolism of Midostaurin can be decreased when combined with Metronidazole.
Metyrapone	The metabolism of Midostaurin can be increased when combined with Metyrapone.
Mexiletine	The metabolism of Mexiletine can be decreased when combined with Midostaurin.
Mianserin	The metabolism of Mianserin can be decreased when combined with Midostaurin.
Miconazole	The metabolism of Midostaurin can be decreased when combined with Miconazole.
Midazolam	The serum concentration of Midazolam can be increased when it is combined with Midostaurin.
Mifepristone	The metabolism of Mifepristone can be decreased when combined with Midostaurin.
Milnacipran	The metabolism of Milnacipran can be decreased when combined with Midostaurin.
Miocamycin	The metabolism of Midostaurin can be decreased when combined with Miocamycin.
Mirabegron	The metabolism of Mirabegron can be decreased when combined with Midostaurin.
Mirtazapine	The metabolism of Mirtazapine can be decreased when combined with Midostaurin.
Mirvetuximab s	The serum concentration of Mirvetuximab Soravtansine can be increased when it is combined with Midostaurin.
Mitapivat	The metabolism of Mitapivat can be decreased when combined with Midostaurin.
Mitotane	The metabolism of Midostaurin can be increased when combined with Mitotane.
Mobocertinib	The serum concentration of Mobocertinib can be decreased when it is combined with Midostaurin.
Modafinil	The metabolism of Modafinil can be decreased when combined with Midostaurin.
Mometasone furoate	The metabolism of Mometasone furoate can be decreased when combined with Midostaurin.
Montelukast	The metabolism of Montelukast can be decreased when combined with Midostaurin.
Morphine	The metabolism of Morphine can be decreased when combined with Midostaurin.
Mosunetuzumab	The metabolism of Midostaurin can be decreased when combined with Mosunetuzumab.
Mycophenolate mol	The metabolism of Mycophenolate mofetil can be decreased when combined with Midostaurin.
Nabilone	The metabolism of Nabilone can be decreased when combined with Midostaurin.
Nafcillin	The metabolism of Midostaurin can be increased when combined with Nafcillin.
Naloxegol	The metabolism of Naloxegol can be decreased when combined with Midostaurin.
Nateglinide	The metabolism of Nateglinide can be decreased when combined with Midostaurin.
Nebivolol	The metabolism of Nebivolol can be decreased when combined with Midostaurin.
Nefazodone	The metabolism of Midostaurin can be decreased when combined with Nefazodone.
Nelfinavir	The metabolism of Midostaurin can be decreased when combined with Nelfinavir.
Neratinib	The serum concentration of Neratinib can be increased when it is combined with Midostaurin.
Netupitant	The metabolism of Netupitant can be decreased when combined with Midostaurin.
Nevirapine	The metabolism of Nevirapine can be decreased when combined with Midostaurin.
Niacin	The metabolism of Midostaurin can be decreased when combined with Niacin.
Nicardipine	The metabolism of Nicardipine can be decreased when combined with Midostaurin.
Nicergoline	The serum concentration of Nicergoline can be increased when it is combined with Midostaurin.
Nifedipine	The metabolism of Nifedipine can be decreased when combined with Midostaurin.
Nilotinib	The metabolism of Nilotinib can be decreased when combined with Midostaurin.
Nilvadipine	The metabolism of Nilvadipine can be decreased when combined with Midostaurin.

Nimesulide	The metabolism of Nimesulide can be decreased when combined with Midostaurin.
Nimodipine	The metabolism of Nimodipine can be decreased when combined with Midostaurin.
Nintedanib	The metabolism of Nintedanib can be decreased when combined with Midostaurin.
Nirmatrelvir	The metabolism of Nirmatrelvir can be decreased when combined with Midostaurin.
Nisoldipine	The metabolism of Nisoldipine can be decreased when combined with Midostaurin.
Nitrazepam	The metabolism of Nitrazepam can be decreased when combined with Midostaurin.
Nitrendipine	The metabolism of Nitrendipine can be decreased when combined with Midostaurin.
Nomegestrol	The metabolism of Nomegestrol can be decreased when combined with Midostaurin.
Nomegestrol ac	The metabolism of Nomegestrol acetate can be decreased when combined with Midostaurin.
Norelgestromin	The metabolism of Norelgestromin can be decreased when combined with Midostaurin.
Norethisterone	The metabolism of Norethisterone can be decreased when combined with Midostaurin.
Norethynodrel	The metabolism of Norethynodrel can be decreased when combined with Midostaurin.
Norgestimate	The metabolism of Norgestimate can be decreased when combined with Midostaurin.
Norgestrel	The metabolism of Norgestrel can be decreased when combined with Midostaurin.
Nortriptyline	The metabolism of Nortriptyline can be decreased when combined with Midostaurin.
Noscapine	The metabolism of Midostaurin can be decreased when combined with Noscapine.
Nylidrin	The metabolism of Nylidrin can be decreased when combined with Midostaurin.
Octreotide	The serum concentration of Midostaurin can be increased when it is combined with Octreotide.
Olaparib	The metabolism of Olaparib can be increased when combined with Midostaurin.
Oliceridine	The serum concentration of Oliceridine can be increased when it is combined with Midostaurin.
Olutasidenib	The therapeutic efficacy of Olutasidenib can be decreased when used in combination with Midostaurin.
Omaveloxolone	The serum concentration of Omaveloxolone can be increased when it is combined with Midostaurin.
Ondansetron	The metabolism of Ondansetron can be decreased when combined with Midostaurin.
Opium	The metabolism of Opium can be decreased when combined with Midostaurin.
Oritavancin	The metabolism of Midostaurin can be increased when combined with Oritavancin.
Orphenadrine	The metabolism of Orphenadrine can be decreased when combined with Midostaurin.
Osilodrostat	The serum concentration of Osilodrostat can be increased when it is combined with Midostaurin.
Osimertinib	The metabolism of Osimertinib can be increased when combined with Midostaurin.
Ospemifene	The metabolism of Ospemifene can be decreased when combined with Midostaurin.
Oxcarbazepine	The metabolism of Midostaurin can be increased when combined with Oxcarbazepine.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Oxetacaine.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Oxybuprocaine.
Oxybutynin	The metabolism of Oxybutynin can be decreased when combined with Midostaurin.
Oxycodone	The metabolism of Oxycodone can be decreased when combined with Midostaurin.
Oxymorphone	The metabolism of Oxymorphone can be decreased when combined with Midostaurin.
Paclitaxel	The metabolism of Paclitaxel can be decreased when combined with Midostaurin.
Pacritinib	The serum concentration of Pacritinib can be increased when it is combined with Midostaurin.
Palbociclib	The metabolism of Palbociclib can be decreased when combined with Midostaurin.
Paliperidone	The metabolism of Paliperidone can be decreased when combined with Midostaurin.
Palonosetron	The metabolism of Palonosetron can be decreased when combined with Midostaurin.
Palovarotene	The serum concentration of Palovarotene can be increased when it is combined with Midostaurin.
Panobinostat	The metabolism of Panobinostat can be decreased when combined with Midostaurin.
Pantoprazole	The metabolism of Pantoprazole can be decreased when combined with Midostaurin.
Paramethadione	The metabolism of Paramethadione can be decreased when combined with Midostaurin.
Parathyroid ho	The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Midostaurin.
Parecoxib	The metabolism of Parecoxib can be decreased when combined with Midostaurin.
Paricalcitol	The metabolism of Paricalcitol can be decreased when combined with Midostaurin.
Paritaprevir	The metabolism of Paritaprevir can be decreased when combined with Midostaurin.
Paroxetine	The metabolism of Paroxetine can be decreased when combined with Midostaurin.
Pasireotide	The metabolism of Midostaurin can be decreased when combined with Pasireotide.
Pazopanib	The metabolism of Pazopanib can be decreased when combined with Midostaurin.
Peginesatide	The risk or severity of Thrombosis can be increased when Peginesatide is combined with Midostaurin.
Pemigatinib	The metabolism of Pemigatinib can be increased when combined with Midostaurin.
Pentamidine	The metabolism of Pentamidine can be increased when combined with Midostaurin.
Pentobarbital	The metabolism of Midostaurin can be increased when combined with Pentobarbital.
Perampanel	The metabolism of Perampanel can be increased when combined with Midostaurin.
Pergolide	The serum concentration of Pergolide can be increased when it is combined with Midostaurin.
Perhexiline	The metabolism of Perhexiline can be decreased when combined with Midostaurin.
Pexidartinib	The metabolism of Pexidartinib can be increased when combined with Midostaurin.
Phenobarbital	The metabolism of Midostaurin can be increased when combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Phenol.
Phenprocoumon	The metabolism of Phenprocoumon can be decreased when combined with Midostaurin.
Phentermine	The metabolism of Phentermine can be decreased when combined with Midostaurin.
Phenylbutazone	The metabolism of Midostaurin can be increased when combined with Phenylbutazone.
Phenytoin	The metabolism of Phenytoin can be decreased when combined with Midostaurin.
Pimavanserin	The metabolism of Pimavanserin can be increased when combined with Midostaurin.
Pimozide	The metabolism of Pimozide can be decreased when combined with Midostaurin.
Pinacidil	The metabolism of Pinacidil can be decreased when combined with Midostaurin.
Pinaverium	The metabolism of Pinaverium can be decreased when combined with Midostaurin.
Pioglitazone	The metabolism of Pioglitazone can be decreased when combined with Midostaurin.
Piperaquine	The metabolism of Piperaquine can be decreased when combined with Midostaurin.
Pipotiazine	The metabolism of Pipotiazine can be decreased when combined with Midostaurin.
Pirtobrutinib	The serum concentration of Pirtobrutinib can be increased when it is combined with Midostaurin.
Pitolisant	The metabolism of Pitolisant can be increased when combined with Midostaurin.
Polatuzumab ve	The risk or severity of adverse effects can be increased when Midostaurin is combined with Polatuzumab vedotin.
Pomalidomide	The metabolism of Pomalidomide can be decreased when combined with Midostaurin.
Ponatinib	The metabolism of Ponatinib can be decreased when combined with Midostaurin.
Ponesimod	The metabolism of Ponesimod can be decreased when combined with Midostaurin.
Posaconazole	The metabolism of Midostaurin can be decreased when combined with Posaconazole.
Potassium Iodide	The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Midostaurin.
Potassium perch	The therapeutic efficacy of Potassium perchlorate can be decreased when used in combination with Midostaurin.
Pralsetinib	The serum concentration of Pralsetinib can be increased when it is combined with Midostaurin.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Pramocaine.
Prazepam	The metabolism of Prazepam can be decreased when combined with Midostaurin.
Praziquantel	The metabolism of Praziquantel can be increased when combined with Midostaurin.
Prednisolone	The metabolism of Prednisolone can be decreased when combined with Midostaurin.
Prednisolone acet	The metabolism of Prednisolone acetate can be decreased when combined with Midostaurin.
Prednisolone pho	The metabolism of Prednisolone phosphate can be decreased when combined with Midostaurin.
Prednisone	The metabolism of Prednisone can be decreased when combined with Midostaurin.
Prednisone acetate	The metabolism of Midostaurin can be increased when combined with Prednisone acetate.
Pregnenolone	The metabolism of Pregnenolone can be decreased when combined with Midostaurin.
Prenylamine	The metabolism of Prenylamine can be decreased when combined with Midostaurin.
Pretomanid	The serum concentration of Pretomanid can be decreased when it is combined with Midostaurin.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Prilocaine.
Primaquine	The metabolism of Primaquine can be decreased when combined with Midostaurin.
Primidone	The metabolism of Midostaurin can be increased when combined with Primidone.
Probenecid	The metabolism of Midostaurin can be increased when combined with Probenecid.
Procaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Procaine.
Prochlorperazine	The metabolism of Prochlorperazine can be decreased when combined with Midostaurin.
Progesterone	The metabolism of Progesterone can be decreased when combined with Midostaurin.

Promazine	The metabolism of Promazine can be decreased when combined with Midostaurin.
Propafenone	The metabolism of Propafenone can be decreased when combined with Midostaurin.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Proparacaine.
Propiverine	The metabolism of Propiverine can be decreased when combined with Midostaurin.
Propofol	The metabolism of Midostaurin can be decreased when combined with Propofol.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Propoxycaine.
Propranolol	The metabolism of Propranolol can be decreased when combined with Midostaurin.
Propylthiouracil	The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Midostaurin.
Protirelin	The therapeutic efficacy of Protirelin can be decreased when used in combination with Midostaurin.
Prucalopride	The metabolism of Prucalopride can be decreased when combined with Midostaurin.
Quazepam	The metabolism of Quazepam can be decreased when combined with Midostaurin.
Quetiapine	The serum concentration of Quetiapine can be increased when it is combined with Midostaurin.
Quinidine	The metabolism of Quinidine can be decreased when combined with Midostaurin.
Quinine	The metabolism of Quinine can be decreased when combined with Midostaurin.
Quinupristin	The metabolism of Midostaurin can be decreased when combined with Quinupristin.
Raloxifene	The metabolism of Midostaurin can be decreased when combined with Raloxifene.
Ramelteon	The metabolism of Ramelteon can be decreased when combined with Midostaurin.
Ranolazine	The metabolism of Ranolazine can be decreased when combined with Midostaurin.
Reboxetine	The metabolism of Reboxetine can be decreased when combined with Midostaurin.
Regorafenib	The metabolism of Regorafenib can be decreased when combined with Midostaurin.
Relugolix	The serum concentration of Relugolix can be decreased when it is combined with Midostaurin.
Remdesivir	The metabolism of Remdesivir can be decreased when combined with Midostaurin.
Repaglinide	The metabolism of Repaglinide can be decreased when combined with Midostaurin.
Retapamulin	The metabolism of Retapamulin can be decreased when combined with Midostaurin.
Ribociclib	The metabolism of Ribociclib can be decreased when combined with Midostaurin.
Rifabutin	The metabolism of Rifabutin can be decreased when combined with Midostaurin.
Rifampicin	The metabolism of Midostaurin can be increased when combined with Rifampicin.
Rifamycin	The metabolism of Midostaurin can be increased when combined with Rifamycin.
Rifapentine	The metabolism of Rifapentine can be decreased when combined with Midostaurin.
Rilonacept	The metabolism of Midostaurin can be increased when combined with Rilonacept.
Rilpivirine	The serum concentration of Rilpivirine can be decreased when it is combined with Midostaurin.
Rimegepant	The metabolism of Rimegepant can be decreased when combined with Midostaurin.
Rimonabant	The metabolism of Rimonabant can be decreased when combined with Midostaurin.
Riociguat	The serum concentration of Riociguat can be increased when it is combined with Midostaurin.
Ripretinib	The serum concentration of Ripretinib can be decreased when it is combined with Midostaurin.
Risperidone	The metabolism of Risperidone can be decreased when combined with Midostaurin.
Ritonavir	The serum concentration of Midostaurin can be increased when it is combined with Ritonavir.
Rivaroxaban	The metabolism of Rivaroxaban can be decreased when combined with Midostaurin.
Rofecoxib	The metabolism of Rofecoxib can be decreased when combined with Midostaurin.
Roflumilast	The serum concentration of Roflumilast can be increased when it is combined with Midostaurin.
Rolapitant	The metabolism of Rolapitant can be decreased when combined with Midostaurin.
Romidepsin	The metabolism of Romidepsin can be decreased when combined with Midostaurin.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Ropivacaine.
Rosiglitazone	The metabolism of Rosiglitazone can be decreased when combined with Midostaurin.
Rosuvastatin	The metabolism of Rosuvastatin can be decreased when combined with Midostaurin.
Rotigotine	The metabolism of Rotigotine can be decreased when combined with Midostaurin.
Roxithromycin	The metabolism of Roxithromycin can be decreased when combined with Midostaurin.
Rucaparib	The metabolism of Midostaurin can be decreased when combined with Rucaparib.
Rufinamide	The metabolism of Midostaurin can be increased when combined with Rufinamide.
Rupatadine	The metabolism of Rupatadine can be decreased when combined with Midostaurin.
Ruxolitinib	The metabolism of Ruxolitinib can be decreased when combined with Midostaurin.
Safinamide	The metabolism of Safinamide can be decreased when combined with Midostaurin.
Salmeterol	The metabolism of Salmeterol can be decreased when combined with Midostaurin.
Salmon calcit	The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Midostaurin.
Samidorphan	The metabolism of Samidorphan can be decreased when combined with Midostaurin.
Saquinavir	The metabolism of Midostaurin can be decreased when combined with Saquinavir.
Sarilumab	The metabolism of Midostaurin can be increased when combined with Sarilumab.
Satralizumab	The serum concentration of Midostaurin can be decreased when it is combined with Satralizumab.
Saxagliptin	The metabolism of Saxagliptin can be decreased when combined with Midostaurin.
Scopolamine	The metabolism of Scopolamine can be decreased when combined with Midostaurin.
Secobarbital	The metabolism of Midostaurin can be increased when combined with Secobarbital.
Secukinumab	The metabolism of Midostaurin can be increased when combined with Secukinumab.
Segesterone aceta	The metabolism of Segesterone acetate can be increased when combined with Midostaurin.
Selegiline	The metabolism of Selegiline can be decreased when combined with Midostaurin.
Selexipag	The metabolism of Selexipag can be decreased when combined with Midostaurin.
Selinexor	The metabolism of Selinexor can be decreased when combined with Midostaurin.
Selpercatinib	The serum concentration of Selpercatinib can be decreased when it is combined with Midostaurin.
Selumetinib	The serum concentration of Selumetinib can be increased when it is combined with Midostaurin.
Sertindole	The metabolism of Sertindole can be decreased when combined with Midostaurin.
Sertraline	The metabolism of Sertraline can be decreased when combined with Midostaurin.
Sibutramine	The metabolism of Sibutramine can be decreased when combined with Midostaurin.
Sildenafil	The metabolism of Sildenafil can be decreased when combined with Midostaurin.
Silodosin	The metabolism of Silodosin can be decreased when combined with Midostaurin.
Siltuximab	The metabolism of Midostaurin can be increased when combined with Siltuximab.
Simeprevir	The metabolism of Simeprevir can be decreased when combined with Midostaurin.
Simvastatin	The risk or severity of myopathy and rhabdomyolysis can be increased when Midostaurin is combined with Simvastatin.
Siponimod	The risk or severity of adverse effects can be increased when Midostaurin is combined with Siponimod.
Sirolimus	The metabolism of Sirolimus can be decreased when combined with Midostaurin.
Sitagliptin	The metabolism of Sitagliptin can be decreased when combined with Midostaurin.
Sitaxentan	The metabolism of Midostaurin can be decreased when combined with Sitaxentan.
Solifenacin	The metabolism of Solifenacin can be decreased when combined with Midostaurin.
Somatostatin	The metabolism of Midostaurin can be decreased when combined with Somatostatin.
Somatrogon	The metabolism of Midostaurin can be increased when combined with Somatrogon.
Sonidegib	The metabolism of Sonidegib can be decreased when combined with Midostaurin.
Sorafenib	The metabolism of Sorafenib can be increased when combined with Midostaurin.
Sotagliflozin	The serum concentration of Sotagliflozin can be decreased when it is combined with Midostaurin.
Sotorasib	The serum concentration of Sotorasib can be decreased when it is combined with Midostaurin.
Sparsentan	The serum concentration of Sparsentan can be increased when it is combined with Midostaurin.
St. John’s Wort	The metabolism of St. John’s Wort can be decreased when combined with Midostaurin.
Stiripentol	The metabolism of Midostaurin can be decreased when combined with Stiripentol.
Sufentanil	The metabolism of Sufentanil can be decreased when combined with Midostaurin.
Sulfadiazine	The metabolism of Sulfadiazine can be decreased when combined with Midostaurin.
Sulfamethoxazole	The metabolism of Midostaurin can be decreased when combined with Sulfamethoxazole.
Sulfinpyrazone	The metabolism of Sulfinpyrazone can be decreased when combined with Midostaurin.
Sunitinib	The metabolism of Sunitinib can be decreased when combined with Midostaurin.
Suvorexant	The metabolism of Suvorexant can be decreased when combined with Midostaurin.
Syn Estrogens, A	The metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Midostaurin.
Synth  Estrogens, B	The metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Midostaurin.
Tacrolimus	The serum concentration of Tacrolimus can be increased when it is combined with Midostaurin.
Tadalafil	The serum concentration of Tadalafil can be increased when it is combined with Midostaurin.

Tamoxifen	The metabolism of Tamoxifen can be decreased when combined with Midostaurin.
Tamsulosin	The metabolism of Tamsulosin can be decreased when combined with Midostaurin.
Tasimelteon	The metabolism of Tasimelteon can be decreased when combined with Midostaurin.
Tazemetostat	The metabolism of Tazemetostat can be decreased when combined with Midostaurin.
Tecovirimat	The metabolism of Midostaurin can be increased when combined with Tecovirimat.
Tegafur	The metabolism of Tegafur can be increased when combined with Midostaurin.
Telaprevir	The metabolism of Midostaurin can be decreased when combined with Telaprevir.
Telithromycin	The metabolism of Midostaurin can be decreased when combined with Telithromycin.
Telotristat ethyl	The serum concentration of Midostaurin can be decreased when it is combined with Telotristat ethyl.
Temsirolimus	The metabolism of Temsirolimus can be decreased when combined with Midostaurin.
Teniposide	The metabolism of Teniposide can be decreased when combined with Midostaurin.
Tenofovir alaf	The metabolism of Tenofovir alafenamide can be decreased when combined with Midostaurin.
Tepotinib	The serum concentration of Tepotinib can be increased when it is combined with Midostaurin.
Terbinafine	The metabolism of Terbinafine can be decreased when combined with Midostaurin.
Terfenadine	The metabolism of Midostaurin can be decreased when combined with Terfenadine.
Teriparatide	The therapeutic efficacy of Teriparatide can be decreased when used in combination with Midostaurin.
Testosterone	The metabolism of Testosterone can be decreased when combined with Midostaurin.
Testosterone cypi	The metabolism of Testosterone cypionate can be decreased when combined with Midostaurin.
Testosterone enan	The metabolism of Testosterone enanthate can be decreased when combined with Midostaurin.
Testosterone prop	The metabolism of Testosterone propionate can be decreased when combined with Midostaurin.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Midostaurin is combined with Tetracaine.
Tetracycline	The metabolism of Tetracycline can be decreased when combined with Midostaurin.
Tezacaftor	The metabolism of Tezacaftor can be decreased when combined with Midostaurin.
Thalidomide	The metabolism of Thalidomide can be decreased when combined with Midostaurin.
Theophylline	The metabolism of Theophylline can be decreased when combined with Midostaurin.
Thiamylal	The metabolism of Thiamylal can be decreased when combined with Midostaurin.
Thiotepa	The metabolism of Thiotepa can be decreased when combined with Midostaurin.
Thyroid, porcine	The therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Midostaurin.
Thyrotropin alfa	The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Midostaurin.
Tiagabine	The metabolism of Tiagabine can be decreased when combined with Midostaurin.
Ticagrelor	The metabolism of Ticagrelor can be increased when combined with Midostaurin.
Tinidazole	The metabolism of Tinidazole can be decreased when combined with Midostaurin.
Tiotropium	The metabolism of Tiotropium can be decreased when combined with Midostaurin.
Tipranavir	The metabolism of Midostaurin can be decreased when combined with Tipranavir.
Tisotumab vedotin	The metabolism of Tisotumab vedotin can be decreased when combined with Midostaurin.
Tivozanib	The metabolism of Tivozanib can be increased when combined with Midostaurin.
Tocilizumab	The metabolism of Midostaurin can be increased when combined with Tocilizumab.
Tocofersolan	The metabolism of Tocofersolan can be decreased when combined with Midostaurin.
Tocopherol	The metabolism of Tocopherol can be decreased when combined with Midostaurin.
Tofacitinib	The metabolism of Tofacitinib can be decreased when combined with Midostaurin.
Tolfenamic acid	The metabolism of Tolfenamic acid can be decreased when combined with Midostaurin.
Tolterodine	The serum concentration of Tolterodine can be increased when it is combined with Midostaurin.
Tolvaptan	The metabolism of Tolvaptan can be decreased when combined with Midostaurin.
Topiramate	The metabolism of Midostaurin can be increased when combined with Topiramate.
Toremifene	The metabolism of Toremifene can be decreased when combined with Midostaurin.
Trabectedin	The metabolism of Trabectedin can be decreased when combined with Midostaurin.
Tramadol	The metabolism of Tramadol can be decreased when combined with Midostaurin.
Trastuzumab emta	The metabolism of Trastuzumab emtansine can be decreased when combined with Midostaurin.
Trazodone	The serum concentration of Trazodone can be increased when it is combined with Midostaurin.
Tretinoin	The metabolism of Tretinoin can be decreased when combined with Midostaurin.
Triamcinolone	The metabolism of Triamcinolone can be decreased when combined with Midostaurin.
Triazolam	The metabolism of Triazolam can be decreased when combined with Midostaurin.
Triclabendazole	The metabolism of Triclabendazole can be decreased when combined with Midostaurin.
Trilostane	The metabolism of Trilostane can be decreased when combined with Midostaurin.
Trimebutine	The metabolism of Trimebutine can be decreased when combined with Midostaurin.
Trimethadione	The metabolism of Trimethadione can be decreased when combined with Midostaurin.
Trimethoprim	The metabolism of Trimethoprim can be decreased when combined with Midostaurin.
Trofinetide	The metabolism of Midostaurin can be decreased when combined with Trofinetide.
Troglitazone	The metabolism of Midostaurin can be increased when combined with Troglitazone.
Troleandomycin	The metabolism of Midostaurin can be decreased when combined with Troleandomycin.
Tucatinib	The metabolism of Tucatinib can be increased when combined with Midostaurin.
Ubrogepant	The serum concentration of Ubrogepant can be increased when it is combined with Midostaurin.
Udenafil	The metabolism of Udenafil can be decreased when combined with Midostaurin.
Ulipristal	The metabolism of Ulipristal can be increased when combined with Midostaurin.
Upadacitinib	The metabolism of Upadacitinib can be increased when combined with Midostaurin.
Valbenazine	The metabolism of Valbenazine can be decreased when combined with Midostaurin.
Valdecoxib	The metabolism of Valdecoxib can be decreased when combined with Midostaurin.
Valproic acid	The metabolism of Midostaurin can be decreased when combined with Valproic acid.
Vandetanib	The metabolism of Vandetanib can be decreased when combined with Midostaurin.
Vardenafil	The metabolism of Vardenafil can be decreased when combined with Midostaurin.
Velpatasvir	The metabolism of Velpatasvir can be decreased when combined with Midostaurin.
Vemurafenib	The metabolism of Vemurafenib can be decreased when combined with Midostaurin.
Venetoclax	The metabolism of Venetoclax can be decreased when combined with Midostaurin.
Venlafaxine	The metabolism of Venlafaxine can be decreased when combined with Midostaurin.
Verapamil	The metabolism of Verapamil can be decreased when combined with Midostaurin.
Vilanterol	The metabolism of Vilanterol can be decreased when combined with Midostaurin.
Vilazodone	The metabolism of Vilazodone can be decreased when combined with Midostaurin.
Viloxazine	The metabolism of Midostaurin can be decreased when combined with Viloxazine.
Vinblastine	The metabolism of Vinblastine can be decreased when combined with Midostaurin.
Vincristine	The metabolism of Vincristine can be decreased when combined with Midostaurin.
Vindesine	The metabolism of Vindesine can be decreased when combined with Midostaurin.
Vinflunine	The metabolism of Vinflunine can be decreased when combined with Midostaurin.
Vinorelbine	The metabolism of Vinorelbine can be decreased when combined with Midostaurin.
Vismodegib	The metabolism of Vismodegib can be decreased when combined with Midostaurin.
Vitamin D	The metabolism of Vitamin D can be decreased when combined with Midostaurin.
Vitamin E	The metabolism of Vitamin E can be decreased when combined with Midostaurin.
Voclosporin	The metabolism of Voclosporin can be decreased when combined with Midostaurin.
Vonoprazan	The therapeutic efficacy of Vonoprazan can be decreased when used in combination with Midostaurin.
Vorapaxar	The metabolism of Vorapaxar can be decreased when combined with Midostaurin.
Voriconazole	The serum concentration of Midostaurin can be increased when it is combined with Voriconazole.
Vortioxetine	The metabolism of Vortioxetine can be increased when combined with Midostaurin.
Voxelotor	The serum concentration of Midostaurin can be increased when it is combined with Voxelotor.
Voxilaprevir	The metabolism of Voxilaprevir can be decreased when combined with Midostaurin.
Warfarin	The metabolism of Warfarin can be decreased when combined with Midostaurin.
Yohimbine	The metabolism of Yohimbine can be decreased when combined with Midostaurin.
Zafirlukast	The metabolism of Midostaurin can be decreased when combined with Zafirlukast.
Zaleplon	The metabolism of Zaleplon can be decreased when combined with Midostaurin.
Zanubrutinib	The metabolism of Zanubrutinib can be increased when combined with Midostaurin.
Zidovudine	The metabolism of Zidovudine can be decreased when combined with Midostaurin.
Zileuton	The metabolism of Zileuton can be decreased when combined with Midostaurin.

Drug-Food Interactions

Pregnancy and Lactations

AU TGA pregnancy category: D
US FDA pregnancy category: Not Assigned

Pregnancy

Lactation

No information is available on the clinical use of midostaurin during breastfeeding. Because midostaurin and its active metabolites are 99.8% bound to plasma proteins, the amount in milk is likely to be low. The manufacturer recommends that breastfeeding be discontinued during midostaurin therapy and for at least 4 months after the last dose. Avoiding breastfeeding is particularly important when midostaurin is given with other cancer chemotherapy agents.

Why is this medication prescribed?

Midostaurin is used with other chemotherapy drugs to treat certain types of acute myeloid leukemia (AML; a type of cancer of the white blood cells). Midostaurin is also used to certain types of mastocytosis (a blood disorder in which there are too many mast cells [a certain kind of white blood cell]). Midostaurin is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of mast and cancer cells.

How should this medicine be used?

Midostaurin comes as a capsule to take by mouth. It is usually taken with food twice a day. Take midostaurin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take midostaurin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open or crush them.

If you vomit after taking midostaurin, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose of midostaurin or tell you to stop taking midostaurin for a period of time or permanently during your treatment. This depends on the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take midostaurin even if you feel well. Do not stop taking midostaurin without talking to your doctor.

Your doctor may tell you to take medication to prevent nausea and vomiting before each dose of midostaurin.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking midostaurin,

• tell your doctor and pharmacist if you are allergic to midostaurin, any other medications, or any of the ingredients in midostaurin capsules. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: boceprevir (no longer available in the U.S.; Victrelis); carbamazepine (Carbatrol, Equetro, Tegretol, others); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Cartia, Tiazac, others); enzalutamide (Xtandi); idelalisib (Zydelig); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); medications used to treat human immunodeficiency virus (HIV) such as cobicistat (Tybost, in Evotaz, in Genvoya, in Prezcobix, in Stribild), elvitegravir (Vitekta), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Technivie, in Viekira), saquinavir (Invirase) and tipranavir (Aptivus); mitotane (Lysodren); nefazodone; phenytoin (Dilantin, Phenytek); posaconazole (Noxafil); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); troleandomycin (not available in the U.S.); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with midostaurin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
• tell your doctor what herbal products you are taking, especially St. John’s wort.
• tell your doctor if you have or have ever had an irregular heartbeat, QT prolongation (a heart problem that may cause irregular heartbeat, fainting, or sudden death), lung, liver, or kidney disease.
• tell your doctor if you are pregnant or plan to become pregnant. If you are a female, you should not become pregnant while you are taking midostaurin and for up to 4 months after your final dose. You will need to have a negative pregnancy test within 7 days before you start taking midostaurin. Talk to your doctor about birth control methods that will work for you. If you are male, you and your female partner should use birth control during your treatment and continue to use birth control for 4 months after your final dose. If you or your partner become pregnant while taking midostaurin, call your doctor immediately. Midostaurin may harm the fetus.
• tell your doctor if you are breastfeeding. You should not breastfeed while you are taking midostaurin and for 4 months after your final dose.
• you should know that this medication may decrease fertility in men and women.

References