Reticulate Acropigmentation of Dohi

Reticulate Acropigmentation of Dohi is a mouthful to say, but essentially, it’s a rare skin condition. Let’s break down the name. “Reticulate” means a net-like pattern, like the interwoven strands of a net. “Acropigmentation” points to color changes in the skin, particularly in the extremities like the hands and feet. Finally, “Dohi” refers to Dr. Takeshi Dohi, the dermatologist who first described this condition. So, in simpler terms, it’s a rare skin issue where net-like patterns and changes in skin color appear on the hands and feet

At its core, Reticulate Acropigmentation of Dohi (RAD) is a skin condition. The name might sound complex, but let’s break it down:

  • Reticulate: This word means net-like or in a pattern resembling a network. Imagine the fine lines or patterns that a fishnet might make.
  • Acropigmentation: “Acro” relates to extremities (like hands and feet), and “pigmentation” refers to the coloration of the skin. So, this term is talking about a color change on the extremities.
  • Dohi: This is simply the name of the doctor who first described the condition.

Putting it all together: RAD is a skin condition characterized by a net-like pattern of darker skin, mostly on the hands and feet, named after Dr. Dohi who first identified it.

Behind every skin condition, there’s a science story. While the exact cause of Reticulate Acropigmentation of Dohi remains a bit of a puzzle, researchers think there’s a genetic link. Genes, like tiny instruction manuals in your body, sometimes have typos. These typos can lead to various conditions, and Reticulate Acropigmentation of Dohi might be one of them. But remember, not everyone with these gene changes gets the condition. It’s like having a recipe with a mistake – the dish might turn out differently, but not always.


It’s crucial to note that the term “Reticulate Acropigmentation of Dohi” primarily describes one type of skin condition. However, the idea of “reticulate pigmentation” can be found in other conditions. Some of these include:

  1. Reticulate Acropigmentation of Kitamura: This is similar to Dohi’s condition but can also come with some small, raised skin lesions.
  2. Dyschromatosis Universalis Hereditaria: This one affects more areas than just the hands and feet. You might see mixed areas of dark and light skin.
  3. Dyschromatosis Symmetrica Hereditaria: This type leads to both dark and light spots but is typically restricted to the hands and feet.

Types of Reticulate Acropigmentation of Dohi:

This condition has a few types, each with its own unique features. Let’s break them down:

  1. Type 1: This is the classic type. It creates patterns that resemble a fishing net or a lace glove on your hands and feet. These patterns might be light or dark in color, depending on your skin tone.
  2. Type 2: Similar to Type 1, this type also forms net-like patterns. But here’s the twist: it can also create spots that look like little islands within the net. It’s like having a map of imaginary lands on your skin!
  3. Type 3: Now, this type is a bit different. Instead of nets or islands, it causes streaks of color on your skin. Picture brushstrokes of different shades, like a painter’s canvas on your hands and feet.


Potential causes of RAD, providing easy-to-understand explanations for each. Our aim is to make this complex topic accessible to everyone while optimizing it for search engines.

1. Genetic Factors

RAD can be linked to genetic factors, meaning it can be passed down from parents to their children. These genes play a role in how the skin’s pigmentation develops.

2. Mutation in the FAM111B Gene

A mutation in the FAM111B gene has been identified as a key contributor to RAD. This gene is responsible for providing instructions for the production of a specific protein important for skin pigmentation.

3. Autosomal Recessive Inheritance

RAD often follows an autosomal recessive inheritance pattern, which means both parents must carry a copy of the mutated gene for their child to develop the condition.

4. Consanguinity

When close relatives have children together, there is a higher likelihood of passing down mutated genes, potentially leading to RAD.

5. Ethnic Predisposition

Certain ethnic groups might have a higher susceptibility to RAD due to specific genetic traits that increase the risk of developing the condition.

6. Hormonal Imbalances

Changes in hormone levels can influence the pigmentation process in the skin, contributing to the development of RAD.

7. UV Exposure

Excessive exposure to ultraviolet (UV) radiation, such as from the sun, can trigger RAD in individuals who are genetically predisposed.

8. Environmental Triggers

Exposure to certain chemicals or environmental factors might interact with genetic susceptibility, leading to the onset of RAD.

9. Oxidative Stress

Increased oxidative stress on the skin cells can disrupt the pigmentation process, potentially causing RAD.

10. Melanocyte Dysfunction

Melanocytes are cells responsible for producing pigment. Dysfunction in these cells due to genetic factors or other triggers can lead to RAD.

11. Inflammatory Pathways

Inflammation within the skin can interfere with pigmentation, and chronic inflammation might be linked to RAD.

12. Abnormal Enzyme Activity

Enzymes play a role in various cellular processes, including pigmentation. Abnormalities in enzyme activity can contribute to RAD development.

13. Disrupted Melanin Production

RAD is characterized by irregular melanin production, the pigment responsible for skin color. Genetic mutations can disrupt this process.

14. Impaired DNA Repair Mechanisms

Defects in DNA repair mechanisms can lead to genetic mutations that increase the risk of RAD.

15. Immune System Interplay

The immune system’s response to various triggers could potentially impact melanocyte function, influencing RAD development.

16. Neurological Factors

Communication between the nervous system and skin cells might influence pigmentation and contribute to RAD.

17. Hormonal Changes during Pregnancy

Pregnancy-related hormonal changes can sometimes trigger or worsen RAD symptoms in predisposed individuals.

18. Medication-induced RAD

Certain medications might interfere with pigmentation processes, leading to RAD as a side effect.

19. Nutritional Deficiencies

Lack of essential nutrients required for healthy skin and pigmentation can contribute to RAD development.

20. Autoimmune Reactions

In some cases, autoimmune reactions targeting melanocytes can result in RAD.

21. Hormone-Related RAD in Adolescents

Hormonal fluctuations during adolescence can sometimes lead to the development or exacerbation of RAD.

22. Skin Trauma or Injury

Physical trauma or injury to the skin can potentially trigger RAD in individuals with a genetic predisposition.

23. Viral Infections

Certain viral infections might trigger an immune response that inadvertently affects pigmentation, contributing to RAD.

24. Hormone Replacement Therapy

Hormone replacement therapy, often used during menopause, can impact skin pigmentation and potentially lead to RAD.

25. Exposure to Toxins

Contact with toxins or pollutants might disrupt melanin production and increase the risk of RAD.

26. Occupational Exposures

Certain occupations that involve exposure to chemicals or environmental factors might increase the risk of RAD.

27. Immunosuppressive Conditions

Conditions that weaken the immune system can alter normal melanocyte function and contribute to RAD.

28. Psychological Stress

Chronic stress might influence hormonal changes that impact pigmentation processes, contributing to RAD.

29. Other Genetic Syndromes

RAD can sometimes be associated with other genetic syndromes, further complicating its development.

30. Unknown Triggers

Despite extensive research, some cases of RAD might have triggers that are not yet fully understood.


Symptoms explained in the simplest terms:

  1. Uneven Skin Color: Think of when you spill a bit of tea on a white shirt, and it leaves a stain. Some areas of the skin might look like they have small, dark ‘stains’.
  2. Dark Patches on the Hands and Feet: Imagine wearing gloves and socks made of a patchy tan. That’s how it may appear – darker patches mainly on the hands and feet.
  3. Freckle-like Spots: Some people have freckles, which are small, light brown spots. People with this condition might have similar spots, but they can look darker.
  4. Skin Lesions: A fancy term for when the skin’s appearance changes. Imagine a smooth road that has some patches or bumps – that’s what a lesion is like on the skin.
  5. Gradual Increase: Like a slow-moving train, these symptoms don’t appear overnight. Instead, they take their time and may become more noticeable over the years.
  6. Starts in Childhood: Imagine noticing these skin changes when you’re in elementary school, maybe around the age when you’d lose your first tooth.
  7. Limited to Certain Areas: Unlike a spilled glass of water that spreads everywhere, these skin changes usually stick to certain areas, mainly the hands, feet, and face.
  8. Clear Borders: Think of drawing with a sharp pencil versus a dull one. The sharp pencil leaves a clear line. Similarly, the dark patches on the skin have well-defined edges.
  9. No Pain or Itching: Thankfully, unlike a pesky mosquito bite, these skin changes don’t itch or hurt.
  10. No Redness or Swelling: Unlike when you stub your toe, and it becomes red and puffy, these skin spots don’t come with any redness or swelling.
  11. Thin Skin: The skin might seem a bit thinner in the affected areas, like a delicate piece of paper versus a regular one.
  12. Smooth Texture: Even though the color changes, the texture remains smooth. It’s like painting a wall a different color but keeping its smooth finish.
  13. Pigmentation Lightens with Age: Think of it as a fading tattoo. Over time, the dark spots might become lighter, but they don’t go away completely.
  14. Some Nails Appear Different: A few nails might seem ridged or rougher, kind of like a mountain range in miniature.
  15. Darkening in Folds: Places where the skin folds, like the inside of the wrist, may show more pronounced darkening. It’s as if those areas got a bit more ‘color’.
  16. Mild Sun Sensitivity: Like how some people might burn easily in the sun, the affected skin might be a bit more sensitive to sunlight.
  17. No Changes in Hair or Teeth: While the skin is the main ‘canvas’ of this condition, the hair and teeth remain unaffected. They stay as they are!
  18. No Effect on Overall Health: Think of it as a painting with a smudge. It might alter the painting’s appearance, but the canvas is still strong and sturdy. Similarly, this condition doesn’t affect a person’s overall health.
  19. Darker Patches Can Be Few or Many: Everyone is unique. Some might have only a few of these dark patches, while others could have many.
  20. Non-Contagious: You can’t ‘catch’ this condition like you would a cold. It’s not spread through touch or any other way.


Diagnoses and tests related to RAPD, explaining them in plain English to improve comprehension and search engine visibility.

1. Clinical Examination: A doctor will visually inspect the affected skin areas, looking for distinctive reticulated pigmentation patterns, which resemble a net-like appearance.

2. Dermatoscopy: Dermatoscopy involves using a special magnifying tool to closely examine the skin’s surface, helping to identify specific pigmentary patterns unique to RAPD.

3. Family History: A medical history review of family members can help establish if RAPD is inherited, as it tends to run in families.

4. Biopsy: A small skin sample is taken and analyzed under a microscope, aiding in confirming the diagnosis and ruling out other conditions.

5. Genetic Testing: DNA analysis can detect specific genetic mutations associated with RAPD, providing a definitive diagnosis.

6. Wood’s Lamp Examination: Using an ultraviolet light, the doctor can observe changes in skin color that might be indicative of RAPD.

7. Dermoscopy: Similar to dermatoscopy, dermoscopy provides a closer look at the skin’s surface using polarized light, assisting in identifying RAPD’s unique features.

8. Skin Patch Test: A small piece of skin is tested with various substances to check for allergic reactions, helping to differentiate RAPD from other skin disorders.

9. Histopathology: A skin sample is examined under a microscope to study tissue changes, which can help confirm the presence of RAPD.

10. Confocal Microscopy: This non-invasive imaging technique provides high-resolution images of skin layers, aiding in identifying RAPD-specific characteristics.

11. Immunohistochemistry: Through specific staining, this test can highlight particular proteins in skin samples, helping to distinguish RAPD from other conditions.

12. Electron Microscopy: High-resolution imaging is used to study cellular structures, aiding in diagnosing RAPD by revealing unique cellular changes.

13. Blood Tests: These tests can help rule out other medical conditions that might cause similar skin symptoms.

14. Polymerase Chain Reaction (PCR): PCR amplifies DNA from a skin sample, making it easier to detect specific genetic mutations linked to RAPD.

15. Physical Examination: A thorough physical assessment can help identify any associated physical abnormalities.

16. Skin Culture: A sample of skin cells is cultured to check for any microbial infections that might be affecting the skin’s appearance.

17. Dermatology Consultation: Seeking input from a dermatologist can help confirm the diagnosis and determine the best course of action.

18. X-ray Imaging: In some cases, X-rays might be conducted to check for underlying bone or joint abnormalities.

19. MRI Scan: MRI scans can provide detailed images of the skin and underlying tissues, assisting in ruling out other conditions.

20. Ultrasound: Ultrasound imaging can help assess the skin’s thickness and identify any deeper tissue changes.

21. Referral to Genetic Specialist: If genetic testing is needed, a referral to a genetic specialist can aid in accurate diagnosis and counseling.

22. Punch Biopsy: A small, round piece of skin is removed for microscopic examination, providing more detailed information.

23. Electron Probe Microanalysis (EPMA): This technique analyzes skin samples for specific chemical elements, contributing to the diagnosis of RAPD.

24. Infrared Imaging: Infrared technology can reveal changes in blood flow and skin temperature, aiding in diagnosis.

25. Reflectance Confocal Microscopy: This advanced imaging method provides high-resolution images of skin layers, helping to identify microscopic RAPD features.

26. Laser Doppler Imaging: Used to assess blood circulation, this test can provide insights into the vascular changes associated with RAPD.

27. High-Frequency Ultrasonography: This technique provides detailed images of the skin’s layers, assisting in identifying structural changes.

28. Skin Symptom Assessment: A detailed analysis of the type and distribution of skin symptoms can aid in diagnosis.

29. Symptom Timeline Analysis: Understanding when symptoms appeared and how they’ve evolved can provide diagnostic clues.

30. Second Opinion: Seeking a second medical opinion can help confirm the initial diagnosis and explore other possible explanations.


Treatments for RAD. For those searching for clear, SEO-optimized content, you’ve come to the right place. Let’s get started!

1. Sunscreen: Before going outdoors, always apply sunscreen. This isn’t just for the beach. Sun exposure can worsen RAD, so keep your skin protected.

2. Topical Steroids: Creams or ointments that help reduce inflammation. They’re not for prolonged use but can offer relief.

3. Hydroquinone: A cream that lightens the skin. It’s often prescribed to even out skin tone, but remember, a little goes a long way.

4. Tretinoin: A vitamin A-derived cream. It boosts skin cell turnover, helping with discoloration.

5. Chemical Peels: These remove the top skin layer, promoting new, more evenly pigmented skin to come through.

6. Microdermabrasion: A procedure using tiny crystals to exfoliate your skin. Think of it as a deep scrub leading to fresher skin.

7. Laser Therapy: Precise beams of light target the discolored areas, breaking down the pigment, and making skin look clearer.

8. Cryotherapy: This involves freezing the affected area with liquid nitrogen. Sounds chilly, but it can help in reducing pigmentation.

9. Azelaic Acid: A cream that has dual benefits – reduces inflammation and lightens the skin.

10. Glycolic Acid: Used in creams and peels, this acid exfoliates the skin, making way for new skin cells.

11. Vitamin C Serums: They brighten and promote an even skin tone.

12. Moisturizers: Hydrated skin heals better. Moisturize daily.

13. Oral Antioxidants: Think of vitamins like C and E. They help your body fight oxidative stress, potentially slowing down RAD progression.

14. Mineral Makeup: It covers pigmentation while also protecting the skin from sun damage.

15. Broad-brimmed Hats: Extra sun protection when outdoors. Fashion meets function!

16. Avoidance of Irritants: If something irritates your skin, avoid it. This can prevent the worsening of RAD.

17. Primrose Oil: Some experts believe it can improve skin health, though it’s not a mainstream RAD treatment.

18. Wear Protective Clothing: Long sleeves and pants can shield your skin from harmful UV rays.

19. Consultation: Regularly check with a dermatologist. They’ll offer guidance tailored to you.

20. LED Light Therapy: Some believe exposing the skin to specific LED light wavelengths can reduce pigmentation.

21. Microneedling: A procedure where tiny needles stimulate your skin, promoting healing and reducing discoloration.

22. Tranexamic Acid: A newer treatment. Oral or topical, it’s believed to help with pigmentation issues.

23. Kojic Acid: Often found in skin-lightening products, it can reduce pigmentation.

24. Arbutin: Derived from berries, this natural ingredient can lighten the skin.

25. Niacinamide: Also known as Vitamin B3, it can reduce inflammation and lighten dark spots.

26. Salicylic Acid: Popular in acne treatments, it also exfoliates, aiding in pigmentation issues.

27. Licorice Extract: A natural ingredient, believed to lighten and brighten the skin.

28. Aloe Vera: This soothing plant can help with inflammation and has mild skin-lightening properties.

29. Stay Informed: New treatments emerge. Keep researching and talking to experts.

30. Join Support Groups: Talking to others with RAD can provide emotional support and insights into new treatments.

In Conclusion

Reticulate Acropigmentation of Dohi may sound complicated, but there’s hope with numerous treatments available. From daily skincare routines, natural remedies, to more intensive procedures, there’s something for everyone. Remember, a personal approach is essential. What works for one might not work for another. Stay positive, informed, and seek guidance from professionals.