Gestational Age Assessment – Indications, Contraindication

Gestational age assessment means figuring out the number of weeks of your pregnancy. A full-term pregnancy is usually 40 weeks. It’s important to assess if gestational age is uncertain or if your baby is smaller or larger than expected. The new Ballard score is commonly used to determine gestational age.

Gestational age is a key piece of data used by healthcare providers to determine the timing of various screening tests and assessments of the fetus and mother throughout pregnancy. Gestational age may be assessed at any time during pregnancy, and several modes of assessment exist, each requiring different equipment or skills and with varying degrees of accuracy. Obtaining more accurate estimates of gestational age through better diagnostic approaches may initiate more prompt medical management of a pregnant patient.

Embryologic age is the time elapsed from the date of conception to the date of delivery and is 2 weeks less than the gestational age. Women may estimate the date of conception based on their time of ovulation as identified by in-home hormonal testing and/or basal body temperature measurements. However, the date of conception is definitively known only when in vitro fertilization or other assisted reproductive techniques are used.

Estimations of gestational age can be based on

  • Date of conception
  • First day of the last menstrual period and cycle length
  • Fetal ultrasonography
  • Physical parameters after birth (eg, using the Ballard score)

The estimated date of confinement (EDC) is the date birth is expected (the due date). The EDC can be calculated as

  • The date of conception + 266 days
  • The last menstrual period (LMP) + 280 days (40 weeks) for women with regular, 28-day menstrual cycles
  • The LMP + 280 days + (cycle length – 28 days) for women with regular menstrual cycles other than 28 days duration

When periods are regular and recorded contemporaneously, the menstrual history is relatively reliable.

Anatomy and Physiology

The uterus is a pelvic organ that will nurture the developing fetus. Approximately 4 weeks after conception, the uterus will increase about 1 cm in size every week. Between 4.5 to 5 weeks of gestation, a gestational sac or intrauterine fluid collection will form. The next remarkable finding occurs between 5 to 6 weeks with the development of the yolk sac. This structure may remain present until 10 weeks. A fetal pole with cardiac activity can be detected between 5.5 to 6 weeks. After this period, the embryo further develops with more discernable organs and anatomical features. When using ultrasound to visualize anatomy, pelvic landmarks include the bladder, uterine wall, vaginal stripe, and rectum. The bladder is typically anterior and inferior to the uterus. The bladder wall will be circular with an anechoic (black) fluid-filled center. The bladder will range in size based on the amount of urine being retained. The uterus will have a thick muscular isoechoic (gray) wall with an anechoic (black) center where an intrauterine pregnancy at varying stages can be identified. Differentiating the bladder from the uterus can be done easily by looking at the thickness of the wall. The uterine wall is significantly thicker than the bladder wall. The vaginal stripe is posterior to the bladder. The rectum will be the most posterior circular structure, on pelvic ultrasound, with either an anechoic (black) or isoechoic (gray) center on the exam.

Indications

All pregnant patients should have a gestational age calculated for safe prenatal evaluation throughout the remainder of the pregnancy for both mother and fetus.

Contraindications

There are no specific contraindications to assessing a pregnant patient’s gestational age. However, the modality utilized to assess gestational age may not be appropriate for certain patients. A transvaginal ultrasound exam should not be performed in a pregnant patient with vaginal bleeding and known placenta previa, a pregnant patient with premature rupture of membranes, and a patient who refuses exam despite informed discussion. There are no specific contraindications to transabdominal ultrasound; however, scanning over an open wound would be suboptimal for patient care and image acquisition.

Equipment

Ultrasound machine with a phased array or curvilinear probe for the transabdominal approach. Endocavitary probe for the transvaginal approach.

Personnel

An experienced ultrasonographer should evaluate gestational age in a pregnant patient. Experience can include specific bedside hands-on training with an ultrasound-credentialed instructor, continuous medical education courses or seminars, or other ultrasound education. The healthcare provider performing the bedside ultrasound evaluation should have specific training for estimating gestational age and feel comfortable making a gestational age estimate based on their previous experience and own-assessment of their capabilities and skill level. For a more accurate assessment of gestational age, a pregnant patient should undergo an evaluation by a certified ultrasound technician.

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Preparation

Preparation for assessment of gestational age by ultrasound includes describing the procedure to the patient and the risks and benefits of using ultrasound to evaluate their pregnancy. Consent should be obtained from your patient before beginning. When performing a transvaginal ultrasound exam, an appropriate chaperone should be present. Patient comfort should be considered throughout the evaluation.

Technique

Prenatal Techniques

Non-Sonographic Methods for Determining Gestational Age

  • Naegele’s Rule  Establish the date of the last menstrual period by obtaining a history from the patient. From this date, add 1 year and 7 days, then subtract 3 months. This will approximate the estimated delivery date. The date of the last known menstrual period will give the approximate start date for age of the fetus.
  • Uterine Size  The uterus has been described as a soft and globular pelvic organ. In pregnancy, the uterus increases in size to accommodate the developing fetus. At approximately 12 weeks gestation the uterus becomes large enough to be palpable just above the pubic symphysis. At 16 weeks gestation, the fundus of the uterus can be palpated at the midpoint between the umbilicus and the pubic symphysis. At 20 weeks gestation, the fundus can be palpable at the level of the umbilicus. After 20 weeks of gestation, the pubic symphysis to fundal height in centimeters should correlate with the week of gestation.

Sonographic Methods for Determining Gestational Age

  • First Trimester Dating Sonographic assessment within the first 13 weeks and 6 days will provide the most accurate estimate of gestational age. Both transvaginal and transabdominal approaches may be used. However, the transvaginal approach may provide a more clear and accurate view of early embryonic structures. Although the gestational sac and yolk sac are the first measurable markers visible on ultrasound, these poorly correlate with gestational age.

    • The crown-rump length (CRL) is the most accurate measurement correlating with gestational age. Using the mean of three measurements, CRL can be determined by using the calipers on the ultrasound machine, measuring a straight line from the outer margin of the cephalic pole to the rump of the embryo. This measurement can be plugged into numerous validated tables and formulas that correlate well with gestational age.
  • Second Trimester Dating  If gestational age is not determined within the first trimester, alternate sonographic techniques may be used to estimate gestational age. These techniques are generally not recommended as first-line options for dating but are more helpful in determining if fetal size is within normal range. These measurements should not change the gestational age or delivery date if a previous CRL has been calculated within the first trimester.

    • Biparietal Diameter (BPD)  This biometric parameter is recommended as a strong modality for dating because it has been extensively studied and is well reproduced. The technique involves a transabdominal approach by positioning the phased array or curvilinear transducer perpendicular to the fetal parietal bones. The calvarium should appear as a hyperechoic (bright white) structure that is smooth and symmetric. The BPD is measured along a plane that intersects the third ventricle and the thalami. Using the caliper function, cursors are placed on the outer edge of the proximal skull and the inner edge of the distal skull. This value will give the biparietal diameter.
    • Head Circumference (HC)  This biometric parameter has been regarded as a good estimator of gestational age with some studies suggesting superiority to the biparietal diameter. This parameter may also be useful clinically in assessing for growth disorders. A similar sonographic approach as the BPD is used here. A phased array or curvilinear transducer is used to visualize a plane that intersects the third ventricle and thalami. However, to achieve the greatest anterior-posterior diameter, the cavum septum pellucidum must be visualized anteriorly, and the tentorial hiatus must be visualized posteriorly. The cerebellum and lateral ventricles should not be visualized in a standard HC view. Using the calipers, mark the cursors on the outer margins of the calvarium bilaterally. The ultrasound should have an elliptical measuring tool that will generate a measurement of the perimeter of the calvarium.
    • Femur Length (FL) The femur can be visualized as early as 10 weeks gestation due to its size and density on ultrasound. Using a phased array or curvilinear transducer, align along the long axis of the closest femur. Proximally, visualize either the femoral head or greater trochanter and distally, visualize the femoral condyle. Using the calipers, measure the length of the diaphysis, at the junction of bone and cartilage, taking care not to include the femoral head, greater trochanter, or femoral condyle.
    • Abdominal Circumference (AC) The biometric parameter is more difficult to measure and is less able to predict gestational age than the other described techniques accurately. However, it may be useful in fetuses with cranial or limb abnormalities and to estimate a fetal weight and note interval growth. Using the phased array or curvilinear transducer, position the transducer perpendicular to the fetal abdominal wall and visualize the symmetric appearance of the lower ribs. This view should be at the largest diameter of the fetal liver. Note, the fetal stomach is often visualized at this level. The umbilical portion of the left portal vein in its shortest view is another hallmark of appropriate positioning. Using the calipers, obtain four calibration points around the abdomen on the skin edge making sure not to include the rib cage. The elliptical tool may also be used to calculate the circumference.
  • Third Trimester Dating  If gestational age has not been determined by the third trimester multiple parameters are correlated with estimated age and fetal maturity. For example, femoral epiphyseal ossification centers are often noted at 32 weeks. Proximal tibial ossification centers are visualized at 35 weeks. The proximal humeral ossification centers appear in the late trimester and have been correlated with fetal lung maturity.

Postnatal Techniques

  • Dubowitz Method – This was the historically standard method of determining postnatal gestational age based on 34 physical and neurologic assessments. These assessments are divided into 6 categories: tone, tone patterns, reflexes, movements, abnormal signs, and behaviors. Scores are assigned based on a detailed illustration sheet. Higher scores correlate with greater maturity. The total score can be plotted on a graph that also correlates with gestational age.
  • New Ballard Score – This improved scoring system is used to determine postnatal gestational age in infants as preterm as 20 weeks. The system is divided into 6 physical maturity components and six neuromuscular components. The physical maturity components include skin, lanugo, plantar creases, breast, ear/eye, and genitals. The neuromuscular components include posture, square window/wrist, arm recoil, popliteal angle, scarf sign, and heel to ear. Detailed illustrations have been created to assist the examiner in determining appropriate scores that correlate with gestational age. This exam is quicker to perform and maybe more tolerable for sicker infants.

How is physical maturity assessed?

The physical assessment includes an exam of the following physical characteristics:

  • Skin texture – Skin may be sticky, smooth, or peeling.
  • Lanugo – This is the soft downy hair on a baby’s body. It’s absent in premature babies. It’s present in full-term babies, but not in babies born late.
  • Plantar creases – These are the creases on the soles of the feet. They range from absent to covering the entire foot.
  • Breast – The thickness and size of the breast tissue and the areola (the darkened area around each nipple) are assessed.
  • Eyes and ears –  Eyelids are checked to see if they are open or fused shut (more likely in a premature baby). The amount of cartilage and stiffness of the ear tissue are also noted.
  • Male genitals – The presence of testes and the look of the scrotum, from smooth to wrinkled, is verified.
  • Female genitals – The appearance and size of the clitoris and the labia are noted.
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How is neuromuscular maturity assessed?

The neuromuscular assessment includes an exam of the following:

  • Posture – How the baby holds his or her arms and legs.
  • Square window – How far the baby’s hands can be flexed toward the wrist.
  • Arm recoil – How well the baby’s arms spring back to a flexed position.
  • Popliteal angle – How well the baby’s knees bend and straighten.
  • Scarf sign – How far the elbows can be moved across the baby’s chest.
  • Heel to ear – How close the baby’s feet can be moved to the ears.

Gestational age assessment is an important way to learn about your baby’s well-being at birth. By identifying any problems, your baby’s healthcare provider can plan the best possible care.

Complications

Prenatal Techniques
Non-Sonographic Methods for Determining Gestational Age
  • Naegele’s Rule –  This rule assumes a standardized 28-day menstrual cycle with fertilization occurring on day 14. However, many women have irregular cycles with variability in the length of the follicular phase affecting ovulation. History of last menstrual period may be confounded by early pregnancy bleeding, hormonal contraceptive use, or incorrect recall of last menstrual period date.
  • Uterine Size  This finding primarily relies on the provider’s physical examination. This may be confounded by maternal factors including but not limited to obesity, multiple gestation, leiomyoma, and fibroids. The mother may also have a retroverted uterus which will alter normal progressive landmarks. Individual practitioner skill and experience make findings less reliable and reproducible.
Sonographic Methods for Determining Gestational Age
  • Crown-rump length (CRL)  This parameter becomes less accurate for predicting gestational age and delivery date with the advancement of gestation due to normal embryonic development and variability in anatomic positioning. Once the CRL exceeds 84 mm, the BDP serves as a better indicator for gestational age.
  • Biparietal Diameter (BPD) – This parameter becomes limited after 22 weeks gestation due to normal biologic development with variations in fetal size and shape. If there is a physiologic or pathologic cause for the skull size and shape to be altered, the BPD may produce false measurements.
  • Head Circumference (HC)  This parameter is useful for obtaining gestation age, but multiple landmarks need to be identified before taking measurements. After 22 weeks, there is significant variation due to normal development affecting size and shape.
  • Femur Length (FC) – Multiple errors may occur when obtaining this parameter including but not limited to, non-ossified portions of the femur and not visualizing the full femur. This can lead to incorrect gestational age calculations. Average femur lengths may differ among certain ethnic groups or can be indicative of pathology. Again, this parameter does have variability after 22 weeks due to normal biologic development.
  • Abdominal Circumference (AC)  This parameter has a wide margin of error for determining gestational age due to multiple factors including asymmetry of the abdomen, changes with respiration and movement, and user skills. Like the other parameters, significant variability is seen after 22 weeks.
  • Ossification Centers These parameters do not directly correlate with exact gestational age. The presence of these ossified centers are rather markers of fetal maturity which is seen later in pregnancy.

Postnatal Techniques

  • Dubowitz Method  Due to a large number of criteria needed to perform the exam, this method may be more difficult to perform on sick and preterm infants. Also, it can take up to 20 minutes to perform this exam. Studies have shown that this method tends to overestimate the gestational age.
  • New Ballard Score  Although this exam is quicker to perform, studies have shown that this system can overestimate gestational age in preterm infants.

References

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