Cefetamet is a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Cefetamet binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Mechanism of Action of Cefetamet
The bactericidal activity of cefetamet results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefetamet highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. Cefetamet is a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Cefetamet binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Indications of Cefetamet
For the treatment of infections due to susceptible strains of microorganisms.
- Intra-Abdominal
- For the treatment of serious infections caused by susceptible strains microorganisms.
- Lower respiratory tract infections, including pneumonia and lung abscess,s
- Urinary tract infections caused by Escherichia coli, Klebsiella species,
- Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
- Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory disease caused
- Bacterial Infections
- Bloodstream Infections
- Otitis media,
- Sinusitis,
- Pharyngotonsillitis,
- Lower respiratory tract infections,
- Acute bacterial exacerbation of chronic bronchitis,
- Tracheobronchitis,
- Pneumonia,
- Urinary tract infections,
- Gonococcal urethritis in men
- Bone and Joint Infections
- Aspiration Pneumonia Cesarean Section
- Bronchitis
- Tonsillitis
Contra-Indications of Cefetamet
- Hemolytic anemia
- Liver problems
- Interstitial nephritis
- Subacute cutaneous lupus erythematosus
- Systemic lupus erythematosus
- Allergies cephalosporins & beta-lactams
Dosage of Cefetamet
Strengths: 500 mg
Adult: 500 mg bid.
Side Effects of Cefetamet
The most common
- mild nausea
- loss of appetite
- vaginal discharge and itching
- swelling of feet or legs
- chest pain
- constipation
- local tenderness or pain at the site of injection
- skin color change, mild diarrhea
- a cough
- diarrhea or loose stools
- difficulty with breathing
- dizziness
- heartburn
More common
- Abdominal or stomach pain, discomfort, or tenderness
- chills or fever
- difficulty with moving
- a headache, severe and throbbing
- joint or back pain
- muscle aching or cramping
- muscle pains or stiffness
- chest pressure or squeezing pain in the chest
- excessive sweating
- feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
- sudden tingling or coldness in an arm or leg
- sudden slow or difficult speech
- sudden drowsiness or need to sleep
- fast breathing
- sharp pain when taking a deep breath
- fast or slow heartbeat
- coughing up blood
- rust colored urine
- decreased amount of urine
Rare
- Anxiety
- change in vision
- seizures
- abnormal or fast heart rate
- tremors
- weight loss
- chest pain or tightness
- confusion
- a cough
- Agitation
- arm, back, or jaw pain
- blurred vision
- chest pain or discomfort
- convulsions
- extra heartbeats
- fainting
- hallucinations
- headache
- irritability
- lightheadedness
- mood or mental changes
- muscle pain or cramps
Drug Interactions of Cefetamet
Cefetamet may interact with the following drugs, supplements, & may change the efficacy of drugs
- aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
- probenecid
- typhoid vaccine
- cholera vaccine,
- amoxicillin
- BCG vaccine
- Aspirin Low Strength (aspirin)
- Diphenhydramine
- Rosuvastatin
- Duloxetine
- Albuterol
- Topiramate
- Carbamazepine
- Vitamin D3 (cholecalciferol)
- Alprazolam
- Cetirizine
- Phenprocoumon
- Picosulfuric acid
- Warfarin
Pregnancy Catagory of Cefetamet
FDA Pregnancy Category B
Pregnancy
It is not known if Cefetamet is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Lactation
This medication may pass into breast milk. If you are a breastfeeding mother and are taking cefetamet it may affect your baby. Talk to your doctor about whether you should continue breastfeeding. It is not known if cefetamet is safe for children under 6 months of age.
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