Alpha-1 antitrypsin is a laboratory test to measure the amount of alpha-1 antitrypsin (A1AT) in your blood.
How the Test is Performed
A blood sample is needed.
How to Prepare for the Test
There is no special preparation.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
This test is helpful in identifying a rare form of emphysema in adults and a rare form of liver disease (cirrhosis) in children and adults caused by an A1AT deficiency . A1AT deficiency is passed down through families. The condition causes the liver to make too little of a protein that protects the lungs and liver from damage.
Everyone has two copies of the gene that makes A1AT. Most people with a lower-than-normal level of A1AT have one normal gene for A1AT, and one abnormal gene. People with two abnormal copies of the gene have more severe disease.
Normal Results
Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.
What Abnormal Results Mean
A lower-than-normal level of A1AT may be associated with:
- Damage of the large airways in the lungs ( bronchiectasis )
- Scarring of the liver ( cirrhosis )
- Chronic obstructive pulmonary disease (COPD)
- Liver tumors
- Yellowing of the skin and eyes due to blocked bile flow ( obstructive jaundice )
- High blood pressure in the large vein leads to the liver (portal hypertension )
Risks
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one person to another, and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Dr. Md. Harun Ar Rashid, MPH, MD, PhD, is a highly respected medical specialist celebrated for his exceptional clinical expertise and unwavering commitment to patient care. With advanced qualifications including MPH, MD, and PhD, he integrates cutting-edge research with a compassionate approach to medicine, ensuring that every patient receives personalized and effective treatment. His extensive training and hands-on experience enable him to diagnose complex conditions accurately and develop innovative treatment strategies tailored to individual needs. In addition to his clinical practice, Dr. Harun Ar Rashid is dedicated to medical education and research, writing and inventory creative thinking, innovative idea, critical care managementing make in his community to outreach, often participating in initiatives that promote health awareness and advance medical knowledge. His career is a testament to the high standards represented by his credentials, and he continues to contribute significantly to his field, driving improvements in both patient outcomes and healthcare practices.
