PUVA-Induced Acrobullous Dermatosis

Dr. Harun Ar Rashid, MD - Arthritis, Bones, Joints Pain, Trauma, and Internal Medicine Specialist Dr. Harun Ar Rashid, MD - Arthritis, Bones, Joints Pain, Trauma, and Internal Medicine Specialist
1 View
Rx Dermatology (A-Z)

PUVA-induced acrobullous dermatosis is a rare skin condition that can result from a medical treatment called PUVA therapy. This article will explain this condition in simple terms, including its types, causes, symptoms, diagnostic tests, and treatment options.

PUVA-induced acrobullous dermatosis is a skin problem that occurs as a side effect of PUVA therapy. PUVA stands for Psoralen plus Ultraviolet A, which is a medical treatment used to manage skin conditions like psoriasis and eczema. However, in some cases, PUVA therapy can lead to this dermatosis.

Types of PUVA-Induced Acrobullous Dermatosis

  1. Bullous Pemphigoid-Like PUVA Dermatosis: This type resembles another skin condition called Bullous Pemphigoid, which leads to blistering and itching.
  2. Pemphigus Vulgaris-Like PUVA Dermatosis: Similar to Pemphigus Vulgaris, this type causes painful blisters and sores on the skin.

Causes of PUVA-Induced Acrobullous Dermatosis

The primary cause of this condition is the use of PUVA therapy, but not everyone who undergoes PUVA treatment will develop it. Other factors that may contribute include:

  1. Genetic predisposition.
  2. Previous history of skin disorders.
  3. Long-term PUVA therapy.
  4. High doses of psoralen medication.

Symptoms of PUVA-Induced Acrobullous Dermatosis

The symptoms of this condition can vary, but common signs include:

  1. Blisters on the skin.
  2. Painful sores or ulcers.
  3. Itching and burning sensation.
  4. Redness and inflammation.
  5. Skin peeling.
  6. Difficulty in swallowing (in severe cases).
  7. Nail changes (in some cases).

Diagnostic Tests for PUVA-Induced Acrobullous Dermatosis

To diagnose this condition, doctors may perform the following tests:

  1. Skin biopsy: A small sample of affected skin is examined under a microscope.
  2. Blood tests: To rule out other autoimmune conditions.
  3. Immunofluorescence studies: Identifies specific antibodies in the skin.
  4. Direct immunofluorescence (DIF) test: Determines the presence of immune deposits in the skin.

Treatment Options for PUVA-Induced Acrobullous Dermatosis

Managing this condition involves a combination of treatments to relieve symptoms and address the underlying causes. Some options include:

  1. Discontinuing PUVA therapy: Stopping the treatment causing the condition is the first step.
  2. Topical steroids: Applied to the affected skin to reduce inflammation.
  3. Oral steroids: Prescribed for severe cases to suppress the immune response.
  4. Immunosuppressive drugs: To control the immune system’s overactivity.
  5. Wound care: Keeping blisters and sores clean to prevent infection.
  6. Pain management: Medications to alleviate discomfort.
  7. Phototherapy with UVB: A different light therapy that may be safer for some patients.
  8. Supportive measures: Adequate hydration and nutrition to aid healing.

Medications Used in PUVA-Induced Acrobullous Dermatosis

Doctors may prescribe various medications to treat the condition and its symptoms. Some of these drugs include:

  1. Prednisone: An oral steroid to reduce inflammation.
  2. Methotrexate: An immunosuppressive drug.
  3. Azathioprine: Another medication that suppresses the immune system.
  4. Topical corticosteroids: Creams or ointments to relieve skin inflammation.
  5. Pain relievers: Over-the-counter or prescription medications for pain management.

Conclusion:

PUVA-induced acrobullous dermatosis is a rare skin condition that can occur as a side effect of PUVA therapy. While it can be challenging to manage, with the right treatment and support, patients can find relief from its symptoms. If you suspect you have this condition or are experiencing any of the mentioned symptoms, consult a dermatologist for a proper diagnosis and treatment plan. Remember, early intervention is essential for better outcomes.

 

Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.

  1. https://medlineplus.gov/skinconditions.html
  2. https://www.aad.org/about/burden-of-skin-disease
  3. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  4. https://www.cdc.gov/niosh/topics/skin/default.html
  5. https://www.skincancer.org/
  6. https://illnesshacker.com/
  7. https://endinglines.com/
  8. https://www.jaad.org/
  9. https://www.psoriasis.org/about-psoriasis/
  10. https://books.google.com/books?
  11. https://www.niams.nih.gov/health-topics/skin-diseases
  12. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  13. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  14. https://dermnetnz.org/topics
  15. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  16. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  17. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  18. https://www.nibib.nih.gov/
  19. https://rxharun.com/rxharun/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/
  20. https://www.nei.nih.gov/
  21. https://en.wikipedia.org/wiki/List_of_skin_conditions
  22. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  23. https://en.wikipedia.org/wiki/Skin_condition
  24. https://oxfordtreatment.com/
  25. https://www.nidcd.nih.gov/health/
  26. https://consumer.ftc.gov/articles/w
  27. https://www.nccih.nih.gov/health
  28. https://catalog.ninds.nih.gov/
  29. https://www.aarda.org/diseaselist/
  30. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  31. https://www.nibib.nih.gov/
  32. https://www.nia.nih.gov/health/topics
  33. https://www.nichd.nih.gov/
  34. https://www.nimh.nih.gov/health/topics
  35. https://www.nichd.nih.gov/
  36. https://www.niehs.nih.gov
  37. https://www.nimhd.nih.gov/
  38. https://www.nhlbi.nih.gov/health-topics
  39. https://obssr.od.nih.gov/
  40. https://www.nichd.nih.gov/health/topics
  41. https://rarediseases.info.nih.gov/diseases
  42. https://beta.rarediseases.info.nih.gov/diseases
  43. https://orwh.od.nih.gov/

References

 

You Might Also Like This :

  1. PUVA Lentigines PUVA lentigines are a skin condition characterized by the development of dark, flat, and benign pigmented spots on the skin. In this article, we will break down PUVA lentigines into simple terms, explaining what they are, their causes, symptoms, diagnostic tests, treatment options, and relevant drugs. Our goal is to make this information easy to […]...
  2. PUVA Keratosis PUVA keratosis, also known as Actinic Keratosis (AK), is a common skin condition caused by long-term sun exposure. This article will simplify complex medical jargon and provide you with easy-to-understand information about PUVA keratosis, including its types, causes, symptoms, diagnostic tests, treatments, and medications. Types of PUVA Keratosis: Actinic Cheilitis: AK affecting the lips. Hypertrophic […]...
  3. Persistent Acantholytic Dermatosis Persistent acantholytic dermatosis is a rare skin condition that is characterized by the formation of persistent, irregularly shaped blisters or erosions on the skin. The blisters are caused by a breakdown in the cohesion of the skin cells, leading to a separation of the cells and the formation of fluid-filled spaces. This condition is often […]...
  4. Benign Papular Acantholytic Dermatosis (BPAD) Benign papular acantholytic dermatosis (BPAD) is a skin condition that is characterized by the formation of small, benign (non-cancerous) papules (raised bumps) on the skin. The papules are usually round, red, or skin-colored and can occur in various sizes and numbers. BPAD is a type of acantholytic dermatosis, which means that the skin cells (acantholysis) […]...
  5. Neutrophilic Dermatosis of the Dorsal Hands Neutrophilic dermatosis of the dorsal hands, often referred to as Sweet’s syndrome, is a rare and perplexing skin condition. It can cause uncomfortable symptoms and may be challenging to diagnose and manage. In this article, we’ll break down the essential information about this condition in simple, easy-to-understand language. We’ll discuss the types, causes, symptoms, diagnostic […]...
  6. Transient Acantholytic Dermatosis (TAD) Transient acantholytic dermatosis (TAD) is a skin condition characterized by the formation of blisters and erosions on the skin that can be itchy and painful. The word “transient” refers to the temporary nature of the condition, while “acantholytic” refers to the loss of the protective outer layer of skin cells. The “dermatosis” part of the […]...
  7. Ichthyosiform Dermatosis Ichthyosiform dermatosis is a group of rare skin disorders characterized by dry, scaly skin. These conditions can be challenging to understand, so let’s break it down into simple terms. In this article, we’ll explore different types of ichthyosiform dermatosis, what causes them, their symptoms, how doctors diagnose them, available treatments, and medications used to manage […]...
  8. Digitate Dermatosis Digitate dermatosis is a skin condition that can cause discomfort and concern. In this article, we’ll explore digitate dermatosis, its various types, what causes it, the symptoms to watch out for, how it’s diagnosed, and the available treatment options. We’ll also discuss some common medications used to manage this condition. Our goal is to provide […]...
  9. Linear IgA Bullous Dermatosis Linear IgA bullous dermatosis (LABD) is a rare autoimmune skin disorder that can cause uncomfortable and sometimes painful skin blisters. This article aims to provide a clear and simple explanation of LABD, covering its types, potential causes, common symptoms, diagnostic tests, available treatments, and medications. By breaking down complex medical jargon into plain English, we […]...
  10. Dermatosis Cinecienta Dermatosis Cinecienta, although not a recognized medical term, appears to be a fictional or hypothetical condition for the purpose of this article. While we cannot provide actual medical information about this condition, we can create a fictitious scenario to help you understand how information about types, causes, symptoms, diagnostic tests, treatments, and medications might be […]...
  11. Acquired Perforating Dermatosis Acquired perforating dermatosis is a skin condition characterized by the formation of perforations or holes in the skin. It is a relatively uncommon condition that can affect people of all ages and races. The condition is not hereditary and is acquired through various factors such as excessive sun exposure, aging, and certain underlying medical conditions. […]...
  12. Ashy Dermatosis Ashy dermatosis, also known as erythema dyschromicum perstans, is a rare skin condition that can affect people of all ages and ethnic backgrounds. This article aims to provide simple, plain English explanations of ashy dermatosis, its types, causes, symptoms, diagnostic tests, treatments, and related drugs. We’ll break down complex medical terminology to enhance readability and […]...
  13. Neutrophilic Dermatosis Neutrophilic dermatosis is a group of skin conditions characterized by inflammation and the presence of a type of white blood cell called neutrophils in the skin. These conditions can cause various symptoms, and their causes can vary. In this article, we will explore the different types of neutrophilic dermatosis, potential causes, common symptoms, diagnostic tests, […]...
  14. Linear IgM Dermatosis of Pregnancy Linear IgM dermatosis of pregnancy, also known as gestational pemphigoid, is a rare skin condition that can occur during pregnancy. In this article, we will provide simple and clear explanations for various aspects of this condition, including its types, causes, symptoms, diagnostic tests, treatments, and drugs. Our goal is to make this information easy to […]...
  15. Pellagra-Like Dermatosis Pellagra-like dermatosis is a condition that resembles pellagra, a nutritional deficiency disease caused by a lack of niacin (vitamin B3) in the diet. However, pellagra-like dermatosis can have various underlying causes and may not be directly related to niacin deficiency. In this article, we will explore the different types of pellagra-like dermatosis, its causes, symptoms, […]...

To Get Daily Health Newsletter

We don’t spam! Read our privacy policy for more info.

Terms and Conditions of Use
Privacy Policy
Cookie Policy
Editorial Policy
Advertising Policy
EU User Consent Policy
Correction Policy
Citation Policy
Ethics and Logical Policies
About Us
Contact Us
Newsletter
Career
Sitemap
Advertise with us
Editorial Board Members
Review Board Member
Team RxHarun
Web Developers Team
Guest Posts and Sponsored Posts
Request for Board Member
Women Writers
Download Mobile Apps
Follow us on Social Media
© 2012 - 2025; All rights reserved by authors. Powered by Mediarx International LTD, a subsidiary company of Rx Foundation.
RxHarun
Logo