Persistent Primitive Trigeminal Artery

The persistent primitive trigeminal artery (PPTA) is a rare condition where an artery, usually present during early fetal development, fails to disappear as it should. This artery connects the internal carotid artery (ICA) with the basilar artery (BA) in the brain. Normally, this artery regresses, but in some people, it persists into adulthood.

Types of PPTA

  1. Saltzman Type I: Direct connection between ICA and BA.
  2. Saltzman Type II: Connection involves the superior cerebellar artery.
  3. Saltzman Type III: Involves the posterior communicating artery.
  4. Other rare types: Uncommon variations in the anatomy.

Causes of PPTA

  1. Genetic factors
  2. Developmental anomalies during fetal growth
  3. Vascular malformations
  4. Incomplete regression of the primitive artery
  5. Hormonal influences during pregnancy
  6. Environmental factors during pregnancy
  7. Maternal infections
  8. Fetal exposure to toxins
  9. Inherited syndromes
  10. Chromosomal abnormalities
  11. Embryological development errors
  12. Structural heart defects
  13. Neurological developmental issues
  14. Fetal hypoxia
  15. Increased maternal age
  16. Maternal diabetes
  17. Autoimmune conditions in mother
  18. Maternal nutritional deficiencies
  19. Premature birth
  20. Unknown causes

Symptoms of PPTA

  1. Headaches
  2. Dizziness
  3. Visual disturbances
  4. Hearing problems
  5. Facial pain
  6. Tinnitus (ringing in ears)
  7. Nausea
  8. Vomiting
  9. Balance problems
  10. Coordination difficulties
  11. Weakness in limbs
  12. Numbness
  13. Speech difficulties
  14. Memory problems
  15. Cognitive impairment
  16. Seizures
  17. Syncope (fainting)
  18. Difficulty swallowing
  19. Pulsatile tinnitus
  20. Double vision

Diagnostic Tests for PPTA

  1. Magnetic Resonance Imaging (MRI): Detailed images of the brain.
  2. Magnetic Resonance Angiography (MRA): Visualizes blood vessels.
  3. Computed Tomography (CT) Scan: Cross-sectional images of the brain.
  4. CT Angiography (CTA): Combines CT scanning and dye to see blood vessels.
  5. Cerebral Angiography: X-ray imaging of brain’s blood vessels.
  6. Doppler Ultrasound: Measures blood flow in vessels.
  7. Electroencephalogram (EEG): Records brain wave patterns.
  8. Blood tests: Checks for underlying conditions.
  9. Genetic testing: Identifies genetic causes.
  10. Neurological examination: Assesses nerve function.
  11. Visual field test: Evaluates vision loss.
  12. Hearing test: Detects hearing impairments.
  13. Lumbar puncture: Analyzes cerebrospinal fluid.
  14. Evoked potentials: Measures electrical activity in brain.
  15. Transcranial Doppler: Evaluates blood flow in brain.
  16. Functional MRI (fMRI): Assesses brain activity.
  17. PET scan: Images metabolic activity in brain.
  18. SPECT scan: Shows blood flow in brain.
  19. Carotid ultrasound: Examines carotid arteries.
  20. Neuropsychological testing: Assesses cognitive functions.

Non-Pharmacological Treatments for PPTA

  1. Observation: Monitoring without immediate intervention.
  2. Lifestyle changes: Healthy diet and regular exercise.
  3. Stress management: Techniques like yoga and meditation.
  4. Physical therapy: Improves balance and coordination.
  5. Occupational therapy: Helps with daily activities.
  6. Speech therapy: Aids in communication skills.
  7. Cognitive therapy: Improves memory and thinking skills.
  8. Biofeedback: Controls bodily functions.
  9. Acupuncture: Reduces pain and stress.
  10. Chiropractic care: Aligns spine and relieves pain.
  11. Massage therapy: Relaxes muscles and reduces stress.
  12. Aromatherapy: Uses essential oils for relaxation.
  13. Hydrotherapy: Water-based treatments.
  14. Nutritional counseling: Optimizes diet for health.
  15. Yoga: Enhances flexibility and reduces stress.
  16. Pilates: Strengthens core muscles.
  17. Tai Chi: Improves balance and reduces stress.
  18. Mindfulness meditation: Reduces anxiety and improves focus.
  19. Breathing exercises: Enhances relaxation.
  20. Reiki: Energy healing technique.
  21. Herbal remedies: Uses plants for healing.
  22. Homeopathy: Treats symptoms with small doses of natural substances.
  23. Reflexology: Applies pressure to feet, hands, or ears.
  24. Art therapy: Uses creativity for healing.
  25. Music therapy: Uses music for emotional support.
  26. Dance therapy: Combines movement and therapy.
  27. Pet therapy: Uses animals to improve mood.
  28. Support groups: Provides emotional support.
  29. Counseling: Offers psychological support.
  30. Education: Informs about the condition and management.

Drugs for PPTA

  1. Pain relievers: E.g., acetaminophen, ibuprofen.
  2. Antidepressants: E.g., fluoxetine, sertraline.
  3. Anticonvulsants: E.g., valproate, topiramate.
  4. Beta-blockers: E.g., propranolol.
  5. Calcium channel blockers: E.g., verapamil.
  6. Antiemetics: E.g., ondansetron.
  7. Anti-anxiety medications: E.g., diazepam.
  8. Corticosteroids: E.g., prednisone.
  9. Antihypertensives: E.g., lisinopril.
  10. Diuretics: E.g., furosemide.
  11. Anticoagulants: E.g., warfarin.
  12. Antiplatelet agents: E.g., aspirin.
  13. Nasal decongestants: E.g., pseudoephedrine.
  14. Antihistamines: E.g., diphenhydramine.
  15. Muscle relaxants: E.g., cyclobenzaprine.
  16. Vasodilators: E.g., nitroglycerin.
  17. Triptans: E.g., sumatriptan.
  18. ACE inhibitors: E.g., enalapril.
  19. Angiotensin II receptor blockers: E.g., losartan.
  20. Statins: E.g., atorvastatin.

Surgeries for PPTA

  1. Endovascular coiling: Blocks the artery with coils.
  2. Surgical clipping: Closes the artery with a clip.
  3. Bypass surgery: Redirects blood flow around the artery.
  4. Stenting: Keeps the artery open with a stent.
  5. Embolization: Blocks the artery with a substance.
  6. Decompression surgery: Relieves pressure on the nerve.
  7. Aneurysm repair: Fixes a bulging artery.
  8. Microsurgical resection: Removes abnormal vessels.
  9. Gamma Knife surgery: Uses radiation to treat the artery.
  10. Balloon angioplasty: Expands the artery with a balloon.

Preventions for PPTA

  1. Regular check-ups: Monitor for vascular issues.
  2. Healthy diet: Reduces risk of vascular problems.
  3. Exercise regularly: Keeps blood vessels healthy.
  4. Avoid smoking: Prevents vascular damage.
  5. Limit alcohol: Reduces vascular risks.
  6. Manage stress: Reduces blood pressure.
  7. Control blood pressure: Prevents vessel damage.
  8. Manage diabetes: Keeps blood vessels healthy.
  9. Maintain healthy weight: Reduces vascular strain.
  10. Regular screenings: Early detection of problems.

When to See a Doctor

  • Severe headaches
  • Dizziness
  • Vision changes
  • Hearing loss
  • Facial pain
  • Tinnitus
  • Nausea and vomiting
  • Balance issues
  • Coordination problems
  • Weakness or numbness
  • Speech difficulties
  • Memory issues
  • Cognitive impairment
  • Seizures
  • Fainting
  • Swallowing difficulties
  • Double vision

Conclusion

Understanding PPTA, its causes, symptoms, and treatments, can help manage this rare condition effectively. Regular check-ups and lifestyle changes are crucial for prevention and early detection. If you experience any concerning symptoms, seek medical advice promptly.

 

Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, geological location, weather and previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.

  1. https://www.ncbi.nlm.nih.gov/books/NBK532297/
  2. https://www.ncbi.nlm.nih.gov/books/NBK549894/
  3. https://pubmed.ncbi.nlm.nih.gov/32119229/
  4. https://pubmed.ncbi.nlm.nih.gov/2644925/
  5. https://pubmed.ncbi.nlm.nih.gov/19514525/
  6. https://pubmed.ncbi.nlm.nih.gov/37988502/
  7. https://www.ncbi.nlm.nih.gov/books/NBK361950/
  8. https://www.ncbi.nlm.nih.gov/books/NBK223475/
  9. https://pubmed.ncbi.nlm.nih.gov/27227247/
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117533/
  11. https://pubmed.ncbi.nlm.nih.gov/32951666/
  12. https://www.ncbi.nlm.nih.gov/books/NBK20369/
  13. https://www.ncbi.nlm.nih.gov/books/NBK597504/
  14. https://medlineplus.gov/skinconditions.html
  15. https://www.aad.org/about/burden-of-skin-disease
  16. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  17. https://www.cdc.gov/niosh/topics/skin/default.html
  18. https://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/syc-20350084
  19. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understanding-Sleep
  20. https://www.cdc.gov/traumaticbraininjury/index.html
  21. https://www.skincancer.org/
  22. https://illnesshacker.com/
  23. https://endinglines.com/
  24. https://www.jaad.org/
  25. https://www.psoriasis.org/about-psoriasis/
  26. https://books.google.com/books?
  27. https://www.niams.nih.gov/health-topics/skin-diseases
  28. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  29. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  30. https://dermnetnz.org/topics
  31. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  32. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  33. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  34. https://www.nibib.nih.gov/
  35. https://rxharun.com/rxharun/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/
  36. https://www.nei.nih.gov/
  37. https://en.wikipedia.org/wiki/List_of_skin_conditions
  38. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  39. https://en.wikipedia.org/wiki/Skin_condition
  40. https://oxfordtreatment.com/
  41. https://www.nidcd.nih.gov/health/
  42. https://consumer.ftc.gov/articles/w
  43. https://www.nccih.nih.gov/health
  44. https://catalog.ninds.nih.gov/
  45. https://www.aarda.org/diseaselist/
  46. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  47. https://www.nibib.nih.gov/
  48. https://www.nia.nih.gov/health/topics
  49. https://www.nichd.nih.gov/
  50. https://www.nimh.nih.gov/health/topics
  51. https://www.nichd.nih.gov/
  52. https://www.niehs.nih.gov
  53. https://www.nimhd.nih.gov/
  54. https://www.nhlbi.nih.gov/health-topics
  55. https://obssr.od.nih.gov/
  56. https://www.nichd.nih.gov/health/topics
  57. https://rarediseases.info.nih.gov/diseases
  58. https://beta.rarediseases.info.nih.gov/diseases
  59. https://orwh.od.nih.gov/

References