Brinzolamide – Uses, Dosage, Side Effects, Interactions

Contraindications of Brinzolamide

• depression
• a disorder of the blood vessels of the brain
• Raynaud’s phenomenon, a condition where blood vessels constrict too much with coldness or stress
• Buerger’s disease
• orthostatic hypotension?, a form of low blood pressure
• severe? renal? impairment

Dosage? of Brinzolamide

Strengths: 1%

Intraocular Hypertension

• One drop in the affected eye(s) three times a day

Glaucoma (Open Angle)

• One drop in the affected eye(s) three times a day

MAXIMUM DOSAGE

• 3 drops/day ophthalmic solution in each affected eye.

• 3 drops/day ophthalmic solution in each affected eye.

• Safety and efficacy have not been established.

• Safety and efficacy have not been established.

Side Effects 0f Brinzolamide

More common

• Blurred vision?
• Discharge from the eye
• dry eyes
• redness, soreness, irritation, or pain? of the eye or eyelid
• skin rash?
• eye pain, redness, or swelling?;
• sensitivity to light;
• the feeling of something is in your eye;
• stomach pain? (upper right side);
• jaundice? (yellowing of your skin or eyes); or
• signs of eye infection?–swelling, redness, severe discomfort, crusting or drainage.

Common

• Chest pain?
• cough?
• crusting in the corner of the eye
• difficulty with swallowing
• dizziness?
• double vision?
• excessive muscle tone
• eye redness, irritation, or pain
• fast heartbeat
• hives?
• itching?, swelling, or other signs of eye or eyelid irritation
• kidney? pain
• muscle stiffness?
• muscle tension or tightness
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seeing double
• shortness of breath?
• sore throat?
• tightness in the chest
• unusual tiredness or weakness
• wheezing?

Rare

• Abdominal or stomach pain
• blistering, peeling, or loosening of the skin
• chills?
• clay-colored stools
• dark urine
• diarrhea
• fever with or without chills
• a general feeling of tiredness or weakness
• headache
• hoarseness
• joint or muscle pain
• loss of appetite
• lower back or side pain
• nausea
• painful or difficult urination
• red or irritated eyes
• red skin lesions, often with a purple center
• sores, ulcers, or white spots on the lips or in the mouth
• swollen or painful glands
• unpleasant breath odor
• unusual bleeding or bruising
• vomiting of blood
• yellow eyes or skin
• Confusion
• irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• seizures
• trembling
• weakness and heaviness of the legs

Drug Interactions of Brinzolamide

• acetazolamide
• aspirin
• bismuth subsalicylate
• choline salicylate
• dichlorphenamide
• diflunisal
• magnesium salicylate
• methazolamide
• salsalate
• sodium salicylate
• sodium thiosalicylate
• topiramate
• zonisamide

Pregnancy Category

• AU TGA pregnancy category – B3
• US FDA pregnancy category – C

• Brinzolamide is classified in FDA pregnancy category C. There are no adequate and well-controlled studies in pregnant women. According to the manufacturer, brinzolamide should be used during pregnancy only if the potential benefit to the mother outweighs the potential risk to the fetus.
• Drugs have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.

• According to the manufacturer, a decision should be made whether to discontinue nursing or to discontinue brinzolamide. It is not known whether this drug is excreted in human milk. It may be prudent to consider an alternative glaucoma therapy in a woman who is breastfeeding, such as dorzolamide and acetazolamide (see individual monographs). Consider the benefits of breastfeeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breastfeeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.
• Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant the use of the drug in pregnant women despite potential risks.

References