Chemotherapy-Induced Acral Erythema

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 8 min read
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Chemotherapy-induced acral erythema is a skin condition that can develop as a side effect of chemotherapy. It often affects the palms of the hands and soles of the feet, causing discomfort and potential complications. In this article, we'll break down the key aspects of chemotherapy-induced...

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Article Summary

Chemotherapy-induced acral erythema is a skin condition that can develop as a side effect of chemotherapy. It often affects the palms of the hands and soles of the feet, causing discomfort and potential complications. In this article, we'll break down the key aspects of chemotherapy-induced acral erythema, making it easy to understand for everyone. Chemotherapy-induced acral erythema, also known as hand-foot syndrome, is a skin...

Key Takeaways

  • This article explains Types of Chemotherapy-Induced Acral Erythema in simple medical language.
  • This article explains Common Causes of Chemotherapy-Induced Acral Erythema in simple medical language.
  • This article explains Symptoms of Chemotherapy-Induced Acral Erythema in simple medical language.
  • This article explains Diagnostic Tests for Chemotherapy-Induced Acral Erythema in simple medical language.
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Definition

Chemotherapy-induced acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema is a skin condition that can develop as a side effect of chemotherapy. It often affects the palms of the hands and soles of the feet, causing discomfort and potential complications. In this article, we’ll break down the key aspects of chemotherapy-induced acral erythema, making it easy to understand for everyone.

Chemotherapy-induced acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema, also known as hand-foot syndrome, is a skin reaction that can occur as a result of chemotherapy treatment. It mainly affects the palms of the hands and the soles of the feet. This condition can be painful and uncomfortable, but understanding its causes, symptoms, diagnosis, and treatment options can help individuals manage it effectively.

Types of Chemotherapy-Induced Acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">Erythema

There is one main type of chemotherapy-induced acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema:

  1. Classic Type: This is the most common form, characterized by redness, swelling, and sometimes blistering on the palms and soles.
  2. Classic Type: This is the more common type and typically appears within days to weeks of starting chemotherapy.
  3. Symmetrical Peripheral Gangrene (SPG): This is a rarer, more severe form that can lead to tissue death in the affected areas.

Common Causes of Chemotherapy-Induced Acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">Erythema

Chemotherapy-induced acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema can be triggered by various chemotherapy drugs. Here are some common causes:

  1. 5-Fluorouracil: This chemotherapy drug is known to frequently cause acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  2. Capecitabine: Another drug often linked to this condition.
  3. Doxorubicin: It can lead to acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema in some cases.
  4. Sorafenib: This targeted therapy drug can also be a cause.
  5. Sunitinib: Used in cancer treatment, it may lead to this skin condition.
  6. Pazopanib: Another targeted therapy drug associated with acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  7. Cytarabine: Commonly used in leukemia treatment, it can cause hand-foot syndrome.
  8. Docetaxel: A chemotherapy drug known for its potential to trigger acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  9. Erlotinib: This targeted therapy drug can lead to this skin reaction.
  10. Pemetrexed: Used in lung cancer treatment, it’s associated with hand-foot syndrome.
  11. Vemurafenib: This targeted therapy drug may also cause acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  12. Lenvatinib: Used in thyroid cancer treatment, it can lead to hand-foot syndrome.
  13. Regorafenib: Another targeted therapy drug that can trigger this condition.
  14. Trifluridine and Tipiracil: Often used in colorectal cancer treatment, they may cause acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  15. Axitinib: Linked to hand-foot syndrome in some patients.
  16. Cabozantinib: Used for kidney and liver cancer treatment, it can cause acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  17. Methotrexate: This chemotherapy drug is occasionally associated with this skin condition.
  18. Fluorouracil cream: Topical application of this medication can lead to hand-foot syndrome.
  19. Paclitaxel: While not as common, it may still trigger acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">erythema.
  20. Irinotecan: In some cases, this chemotherapy drug can result in this skin reaction.

Symptoms of Chemotherapy-Induced Acral allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।" data-rx-term="erythema" data-rx-definition="Erythema means skin redness, often from irritation, allergy, infection, or inflammation. সহজ বাংলা: চামড়া লাল হয়ে যাওয়া।">Erythema

Recognizing the symptoms of chemotherapy-induced acral erythema is crucial for early intervention. Common symptoms include:

  1. Redness: The affected areas of the hands and feet become red or pink.
  2. Swelling: Swelling may occur, making it difficult to wear shoes or use hands comfortably.
  3. Tenderness: The skin can become tender, making simple tasks painful.
  4. Blisters: In more severe cases, blisters may form, leading to open sores.
  5. Peeling or Flaking: The skin may peel or flake, causing discomfort.
  6. Burning Sensation: A burning or tingling sensation in the affected areas.
  7. Pain: Pain can range from mild discomfort to severe, affecting daily activities.
  8. Itching: Itching may accompany the other symptoms.
  9. Warmth: The affected areas can feel warmer than usual.
  10. Difficulty Walking: Severe cases can make walking painful and challenging.
  11. Difficulty Using Hands: Simple tasks like gripping objects can become difficult.
  12. Numbness: Some individuals may experience numbness in the affected areas.
  13. Cracked Skin: Skin on the hands and feet may crack, leading to further discomfort.
  14. Ulcers: In rare cases, ulcers may develop, requiring medical attention.
  15. Painful Nails: Nails may become painful and discolored.
  16. Changes in Skin Texture: The skin may become thicker or harder.
  17. Increased Sensitivity to Temperature: Affected areas may be more sensitive to hot or cold temperatures.
  18. Difficulty Sleeping: Pain and discomfort can affect sleep quality.
  19. Emotional Impact: The condition can cause emotional distress and anxiety.
  20. Impaired Quality of Life: Overall, chemotherapy-induced acral erythema can significantly impact the quality of life.

Diagnostic Tests for Chemotherapy-Induced Acral Erythema

Diagnosing chemotherapy-induced acral erythema typically involves a physical examination by a healthcare provider. However, additional tests may be needed to rule out other conditions and assess the severity. Common diagnostic tests include:

  1. Clinical Examination: A healthcare provider will visually inspect the affected areas to identify characteristic symptoms.
  2. Medical History: Discussing the patient’s chemotherapy treatment history is crucial for diagnosis.
  3. Biopsy: In rare cases, a skin biopsy may be performed to confirm the diagnosis and rule out other skin conditions.
  4. Imaging: Imaging tests like X-rays may be used if there are concerns about bone involvement.
  5. Blood Tests: Blood tests can help assess the overall health and rule out other potential causes of similar symptoms.
  6. Electromyography (EMG): EMG may be used to assess nerve function in severe cases.

Treatment Options for Chemotherapy-Induced Acral Erythema

Managing chemotherapy-induced acral erythema focuses on relieving symptoms and improving quality of life. Treatment options include:

  1. Topical Creams: Topical creams containing steroids or urea can help reduce inflammation and relieve discomfort.
  2. Pain Medications: Over-the-counter or prescription pain medications can alleviate pain and discomfort.
  3. Emollients: Using moisturizers and emollients can prevent dryness and skin cracking.
  4. Cool Compresses: Applying cool compresses to the affected areas can soothe burning sensations.
  5. Avoiding Triggers: Identifying and avoiding triggers such as friction or heat can prevent worsening of symptoms.
  6. Orthopedic Shoes: Wearing orthopedic shoes or cushioned insoles can ease foot pain.
  7. Elevation: Elevating the feet when resting can reduce swelling.
  8. Hand and Foot Care: Practicing gentle hand and foot care to prevent infection and further damage.
  9. Dose Adjustment: In some cases, chemotherapy doses may need to be adjusted or temporarily stopped.
  10. Alternative Chemotherapy: Switching to a different chemotherapy drug with a lower risk of acral erythema may be considered.
  11. Corticosteroid Injections: In severe cases, corticosteroid injections may be administered.
  12. Oral Medications: Certain oral medications, such as pyridoxine (vitamin B6), may be prescribed to manage symptoms.
  13. Physical Therapy: Physical therapy can help improve mobility and reduce pain.
  14. Laser Therapy: Laser therapy may be used to treat severe cases.
  15. Wound Care: Proper wound care is essential for preventing infection in cases with open sores.
  16. Nail Care: Specialized nail care may be needed if the nails are affected.
  17. Psychological Support: Counseling or support groups can help individuals cope with the emotional impact of the condition.
  18. Hydration: Staying well-hydrated can help prevent skin dryness.
  19. Sun Protection: Protecting the skin from the sun can prevent further irritation.
  20. Rest: Resting and avoiding excessive physical activity can promote healing.

Drugs and Medications for Chemotherapy-Induced Acral Erythema

Several drugs and medications may be prescribed to manage the symptoms of chemotherapy-induced acral erythema. These include:

  1. Corticosteroid Creams: Topical creams with corticosteroids can reduce inflammation and itching.
  2. Urea Creams: Urea-containing creams can help moisturize and soften the skin.
  3. Pain Relievers: Over-the-counter pain relievers like ibuprofen or acetaminophen may be recommended.
  4. Antihistamines: Antihistamines can relieve itching.
  5. Vitamin B6 (Pyridoxine): This vitamin can be prescribed to alleviate symptoms.
  6. Pain Medications: Prescription pain medications may be necessary for severe pain.
  7. Antibiotics: If open sores or ulcers develop, antibiotics may be prescribed to prevent infection.
  8. Laser Therapy Medications: Medications may be used in conjunction with laser therapy for treatment.
  9. Immunomodulatory Agents: These medications may be considered in severe cases.
  10. Emollients and Moisturizers: These products help maintain skin hydration.
  11. Anti-inflammatory Medications: Prescription anti-inflammatory drugs can reduce swelling.
  12. Nerve Pain Medications: Medications that target nerve pain may be prescribed.
  13. Biologics: In certain cases, biological drugs may be used.
  14. Calcium Channel Blockers: These medications can help manage symptoms.
  15. Wound Dressings: Specialized wound dressings may be used for open sores.
  16. Vasoactive Agents: These drugs can help improve blood flow in the affected areas.
  17. Immune Suppressive Medications: In severe cases, medications that suppress the immune system may be considered.
  18. Anti-VEGF Agents: Some targeted therapy drugs may be used in combination with other treatments.
  19. Analgesic Creams: Topical analgesic creams can provide pain relief.
  20. Antifungal Medications: If fungal infections develop, antifungal medications may be necessary.

Conclusion

Chemotherapy-induced acral erythema can be a challenging side effect of cancer treatment, but with the right approach, it can be managed effectively. Recognizing the causes, symptoms, diagnosis, and treatment options is essential for individuals undergoing chemotherapy and their caregivers. If you or a loved one experiences symptoms of chemotherapy-induced acral erythema, don’t hesitate to seek medical advice and explore the available treatments to improve your comfort and quality of life during this challenging time.

Disclaimer: Each person’s journey is unique, always seek the advice of a medical professional before trying any treatments to ensure to find the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this page or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.

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Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

RX Patient Help

Ask a health question safely

Write your symptom story. A health professional or site editor can review it before any answer is prepared. This box is not for emergency care.

Emergency first: Severe chest pain, breathing trouble, unconsciousness, stroke signs, severe injury, heavy bleeding, or rapidly worsening symptoms need urgent local medical care now.

Frequently Asked Questions

Is this article a replacement for a doctor?

No. It is educational content only. Patients should consult a qualified clinician for diagnosis and treatment.

When should I seek urgent care?

Seek urgent care for severe symptoms, rapidly worsening condition, breathing difficulty, severe pain, neurological changes, or any emergency warning sign.

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