Benign Symmetric Lipomatosis

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 12 min read
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Benign Symmetric Lipomatosis
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Benign symmetric lipomatosis, also known as Madelung's disease or Launois-Bensaude syndrome, is a rare condition characterized by the growth of multiple, symmetrical, benign fat deposits (lipomas) in the neck, shoulders, upper arms, and upper back. The exact cause of this condition is unknown, but it...

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বাংলা রোগী নোট এখনো যোগ করা হয়নি। পোস্ট এডিটরে “RX Bangla Patient Mode” বক্স থেকে সহজ বাংলা সারাংশ যোগ করুন।

এই তথ্য শিক্ষা ও সচেতনতার জন্য। এটি ডাক্তারি পরীক্ষা, রোগ নির্ণয় বা প্রেসক্রিপশনের বিকল্প নয়।

Article Summary

Benign symmetric lipomatosis, also known as Madelung's disease or Launois-Bensaude syndrome, is a rare condition characterized by the growth of multiple, symmetrical, benign fat deposits (lipomas) in the neck, shoulders, upper arms, and upper back. The exact cause of this condition is unknown, but it is believed to be related to an abnormal accumulation of fat cells in these areas. There are two main types...

Key Takeaways

  • This article explains Causes in simple medical language.
  • This article explains Symptoms in simple medical language.
  • This article explains Diagnosis in simple medical language.
  • This article explains Treatment in simple medical language.
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Definition

Benign symmetric lipomatosis, also known as Madelung’s disease or Launois-Bensaude syndrome, is a rare condition characterized by the growth of multiple, symmetrical, benign fat deposits (lipomas) in the neck, shoulders, upper arms, and upper back. The exact cause of this condition is unknown, but it is believed to be related to an abnormal accumulation of fat cells in these areas.

There are two main types of benign symmetric lipomatosis: the classical form and the acquired form.

Classical Form: The classical form of benign symmetric lipomatosis is also known as Launois-Bensaude syndrome. It is a congenital condition that is inherited in an autosomal dominant pattern, meaning that a person has a 50% chance of inheriting the condition from an affected parent. This form of condition is characterized by the gradual accumulation of fat deposits in the neck, shoulders, upper arms, and upper back. It is most commonly diagnosed in middle-aged men.

Acquired Form: The acquired form of benign symmetric lipomatosis is also known as Madelung’s disease. Unlike the classical form, this type is not inherited and can occur at any age. It is more common in men and is often associated with excessive alcohol consumption. The fat deposits in the acquired form are usually larger and more numerous than in the classical form.

Both forms of benign symmetric lipomatosis are benign, meaning that they do not spread to other parts of the body or become cancerous. However, the fat deposits can cause cosmetic concerns and can also interfere with movement and cause discomfort. In severe cases, the fat deposits can put pressure on the surrounding tissues and organs, leading to complications such as difficulty swallowing or breathing.

Causes

The exact cause of this condition is not known, but there are several theories and factors that have been proposed to explain its development. Here is a list of 20 possible causes of benign symmetric lipomatosis:

  1. Genetics: Studies have suggested that there may be a genetic component to the development of benign symmetric lipomatosis. Some families have been found to have multiple members affected by the condition, suggesting that there may be a hereditary component.
  2. Alcoholism: Alcoholism has been identified as a risk factor for the development of benign symmetric lipomatosis. Excessive alcohol consumption can cause fat to accumulate in the neck, shoulders, and upper arms, which can eventually lead to the development of the condition.
  3. Endocrine disorders: Certain endocrine disorders, such as thyroid gland makes too little hormone. সহজ বাংলা: থাইরয়েড হরমোন কম।" data-rx-term="hypothyroidism" data-rx-definition="Hypothyroidism means the thyroid gland makes too little hormone. সহজ বাংলা: থাইরয়েড হরমোন কম।">hypothyroidism, have been linked to the development of benign symmetric lipomatosis. This is thought to be due to hormonal imbalances that can cause fat to accumulate in certain areas of the body.
  4. Metabolic disorders: Metabolic disorders, such as insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">diabetes and obesity, have also been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of high insulin levels on fat storage and distribution.
  5. Nutritional deficiencies: Nutritional deficiencies, such as a lack of essential fatty acids, vitamins, and minerals, have been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of these deficiencies on fat storage and distribution.
  6. Chronic infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation: Chronic inflammation, such as that seen in conditions like stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।" data-rx-term="arthritis" data-rx-definition="Arthritis means joint inflammation causing pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।">arthritis: Rheumatoid arthritis is an autoimmune joint disease causing inflammation, pain, and swelling. সহজ বাংলা: রোগপ্রতিরোধ ব্যবস্থার ভুল আক্রমণে জয়েন্টের প্রদাহ।" data-rx-term="rheumatoid arthritis" data-rx-definition="Rheumatoid arthritis is an autoimmune joint disease causing inflammation, pain, and swelling. সহজ বাংলা: রোগপ্রতিরোধ ব্যবস্থার ভুল আক্রমণে জয়েন্টের প্রদাহ।">rheumatoid arthritis, has been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of inflammation on fat storage and distribution.
  7. Medications: Certain medications, such as corticosteroids, have been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of these medications on fat storage and distribution.
  8. Immune system disorders: Immune system disorders, such as autoimmune diseases, have been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of these disorders on fat storage and distribution.
  9. Infections: Certain infections, such as human immunodeficiency virus (HIV), have been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of these infections on the immune system and fat storage and distribution.
  10. Liver disease: Liver disease, such as cirrhosis, has been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of liver disease on fat storage and distribution.
  11. Kidney disease: Kidney disease, such as renal failure, has been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of kidney disease on fat storage and distribution.
  12. Cardiovascular disease: Cardiovascular disease, such as heart disease and stroke, has been linked to the development of benign symmetric lipomatosis. This is thought to be due to the effects of cardiovascular disease on fat storage and distribution.
  13. Tumor growth: Tumor growth, such as that seen in conditions like liposarcoma, has been linked

Symptoms

The condition is characterized by the growth of benign fat deposits in the neck, upper arms, and upper back. The following is a list of 20 common symptoms associated with benign symmetric lipomatosis:

  1. Swelling: The most common and noticeable symptom of benign symmetric lipomatosis is the presence of swelling or lumps in the neck, upper arms, and upper back. These lumps may be soft and rubbery to the touch, and they may grow slowly over time.
  2. Pain: Some people with benign symmetric lipomatosis may experience pain or discomfort in the areas where the lumps are growing.
  3. Numbness: Some individuals may experience numbness or tingling in the affected areas, which can be a sign of nerve compression caused by the growth of the fat deposits.
  4. Weakness: Some people with benign symmetric lipomatosis may experience weakness in the affected areas, which can make it difficult to perform daily activities.
  5. Difficulty swallowing: In some cases, the fat deposits in the neck may cause difficulty swallowing or breathing.
  6. Hoarseness: The growth of fat deposits in the neck may also cause hoarseness or changes in the voice.
  7. Loss of mobility: As the fat deposits grow and become more pronounced, they may limit the range of motion in the affected areas, making it difficult to perform certain activities.
  8. Breathing difficulties: In severe cases, the growth of fat deposits in the neck may cause breathing difficulties, which can be life-threatening.
  9. Fatigue: Some people with benign symmetric lipomatosis may experience fatigue or weakness, which can be a result of the body’s efforts to cope with the growth of the fat deposits.
  10. Weight loss: Some individuals may experience unintentional weight loss as a result of the growth of the fat deposits and the associated discomfort and difficulty in performing daily activities.
  11. Poor appetite: The growth of the fat deposits and associated discomfort may also lead to a loss of appetite and difficulty eating.
  12. Mood changes: Some individuals may experience mood changes, such as depression or anxiety, as a result of the physical and emotional toll of living with benign symmetric lipomatosis.
  13. Insomnia: The discomfort and pain associated with benign symmetric lipomatosis may cause insomnia or difficulty sleeping.
  14. Skin changes: The growth of fat deposits may cause changes in the skin, such as redness, itching, or thickening.
  15. Warm to the touch: The lumps associated with benign symmetric lipomatosis may feel warm to the touch, which can be a sign of inflammation.
  16. Increased sweating: Some individuals may experience increased sweating in the affected areas, which can be a result of the body’s efforts to cope with the growth of fat deposits.
  17. Limited range of motion: As the fat deposits grow, they may limit the range of motion in the affected areas, making it difficult to perform certain activities.
  18. Difficulty breathing: In severe cases, the growth of fat deposits in the neck may cause breathing difficulties, which can be life-threatening.
  19. Heart palpitations: In some cases, the growth of fat deposits in the neck may cause heart palpitations or changes in heart rate.
  20. Physical deformity: Over time, the growth of fat deposits may cause physical deformities in the affected areas, which can be noticeable and disfiguring.

Diagnosis

The exact cause of benign symmetric lipomatosis is unknown, but it is believed to be associated with hormonal imbalances, genetic predisposition, and certain metabolic disorders.

Here is a list of diagnoses and tests that can be used to diagnose and evaluate benign symmetric lipomatosis:

  1. Clinical evaluation: A thorough physical examination and medical history review by a doctor is usually the first step in diagnosing benign symmetric lipomatosis. The physician will look for the characteristic growths of adipose tissue and assess their size, location, and number.
  2. Imaging studies: Imaging studies such as X-rays, CT scans, MRI scans, and ultrasounds can help to confirm the diagnosis of benign symmetric lipomatosis and rule out other conditions with similar symptoms.
  3. Biopsy: A biopsy of the affected tissue can be performed to confirm the diagnosis and rule out malignancy. A biopsy involves removing a small sample of tissue for laboratory analysis.
  4. Lipid profile: A lipid profile test is used to measure the levels of cholesterol and other lipids in the blood. This test can help to identify any underlying lipid disorders that may be contributing to the development of benign symmetric lipomatosis.
  5. Hormonal evaluation: Hormonal evaluation may include tests for levels of hormones such as testosterone, estrogen, and insulin. Abnormal levels of these hormones can contribute to the development of benign symmetric lipomatosis.
  6. Genetic testing: Genetic testing can be performed to determine if there is a genetic predisposition to benign symmetric lipomatosis.
  7. Complete blood count (CBC): A CBC is a blood test that measures the levels of various components of the blood, such as red and white blood cells and platelets.
  8. Erythrocyte sedimentation rate (ESR): The erythrocyte sedimentation rate is a blood test that measures the rate at which red blood cells settle to the bottom of a test tube. An elevated ESR can indicate inflammation or infection.
  9. C-reactive protein (CRP) test: The CRP test is a blood test that measures the levels of a protein produced by the liver in response to inflammation.
  10. HbA1c test: The HbA1c test is a blood test that measures the average blood glucose levels over the past 2-3 months. It is used to diagnose and monitor diabetes.
  11. Insulin resistance test: The insulin resistance test measures how well the body uses insulin to control blood sugar levels.
  12. Thyroid function tests: Thyroid function tests are used to evaluate the function of the thyroid gland and to diagnose thyroid disorders.
  13. Adrenal gland function tests: Adrenal gland function tests are used to evaluate the function of the adrenal glands and to diagnose adrenal gland disorders.
  14. Liver function tests: Liver function tests are used to evaluate the function of the liver and to diagnose liver disorders.
  15. Kidney function tests: Kidney function tests are used to evaluate the function of the kidneys and to diagnose kidney disorders.
  16. Fasting glucose test: The fasting glucose test measures the levels of glucose in the blood after an overnight fast.

Treatment

There is currently no cure for benign symmetric lipomatosis, but there are various treatments that can help manage the symptoms and reduce the size of the lipomas. Here are 20 possible treatments:

  1. Observation: In some cases, lipomas may not cause any symptoms or complications and may not require treatment. In such cases, a doctor may simply observe the growth of the lipomas over time.
  2. Liposuction: Liposuction is a surgical procedure that involves removing fat deposits using a suction device. This can be an effective treatment for lipomas that are small and cause no symptoms.
  3. Excision: Excision is a surgical procedure in which the entire lipoma is removed along with a margin of healthy tissue. This is typically recommended for larger lipomas that are causing discomfort or affecting mobility.
  4. Radiation therapy: Radiation therapy uses high-energy beams to shrink or kill the cells in a lipoma. This treatment is typically recommended for people who are not candidates for surgery or have multiple lipomas that cannot be surgically removed.
  5. Cryotherapy: Cryotherapy involves freezing the lipoma using liquid nitrogen. This can cause the lipoma to shrink or disappear completely.
  6. Chemotherapy: Chemotherapy involves using drugs to shrink or kill the cells in a lipoma. This treatment is typically recommended for people with advanced cases of benign symmetric lipomatosis.
  7. Lipotherapy: Lipotherapy is a minimally invasive procedure that involves injecting a solution into the lipoma to shrink it. This can be an effective treatment for small lipomas.
  8. Laser therapy: Laser therapy uses high-energy light to shrink or destroy the cells in a lipoma. This treatment is typically recommended for people with small lipomas that are causing discomfort.
  9. Electrodessication and curettage (ED&C): ED&C is a procedure that involves using an electric current to destroy the cells in a lipoma and then removing the remaining tissue using a curette. This can be an effective treatment for small lipomas.
  10. Sclerotherapy: Sclerotherapy involves injecting a solution into the lipoma to shrink it. This treatment is typically recommended for people with small lipomas that are causing discomfort.
  11. Ethanol injection: Ethanol injection involves injecting alcohol into the lipoma to shrink it. This treatment is typically recommended for people with small lipomas that are causing discomfort.
  12. Platelet-rich plasma (PRP) therapy: PRP therapy involves injecting a concentrate of platelets into the lipoma to promote healing and reduce inflammation. This treatment is typically recommended for people with small lipomas that are causing discomfort.
  13. High-intensity focused ultrasound (HIFU): HIFU is a non-invasive procedure that uses high-energy sound waves to destroy the cells in a lipoma. This treatment is typically recommended for people with small lipomas that are causing discomfort.
  14. Stem cell therapy: Stem cell therapy involves injecting stem cells into the lipoma to promote healing and reduce inflammation. This treatment is typically recommended for people with small lipomas that are causing discomfort.
  15. Herbal remedies: Some people use herbal remedies, such as turmeric, ginger, and green tea, to manage

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  9. https://www.aad.org/about/burden-of-skin-disease
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What to tell the doctor

  • Write when the problem started and how it changed.
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Questions to ask

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OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
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Avoid these mistakes

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Doctor to discuss: Doctor / qualified healthcare provider
Tests to discuss with doctor
  • Basic vital signs: temperature, pulse, blood pressure, oxygen level if needed
  • Relevant blood, urine, imaging, or specialist tests only after clinical assessment
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Benign Symmetric Lipomatosis

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

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Frequently Asked Questions

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    February 28, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  5. Common Variable Agammaglobulinemia

    DefinitionCommon variable agammaglobulinemia is usually used to describe common variable immunodeficiency (CVID) – a primary immune system disease where the body makes very low levels of...

    February 26, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  6. Multiple Pituitary Hormone Deficiencies (MPHD)

    DefinitionMultiple pituitary hormone deficiencies (MPHD) means that the pituitary gland is not making several different hormones at the same time, not just one. The pituitary is...

    February 26, 2026 • Rx Endocrinology, Enzymes and Hormonal Diseases (A - Z)
  7. Combined Pituitary Hormone Deficiency (CPHD)

    DefinitionCombined pituitary hormone deficiency (CPHD) is a health problem where the pituitary gland does not make enough of more than one of its hormones at the...

    February 25, 2026 • Rx Endocrinology, Enzymes and Hormonal Diseases (A - Z)
  8. Epistaxis

    DefinitionEpistaxis is the medical word for a nosebleed. It means that blood is coming out from inside the nose, from small blood vessels in the lining...

    February 25, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  9. Nose Bleed

    DefinitionA nosebleed is when blood comes out from inside the nose because tiny blood vessels (capillaries) in the nose lining break and leak. Doctors call this...

    February 24, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  10. Combined Oxidative Phosphorylation Defect Type 14

    DefinitionCombined oxidative phosphorylation defect type 14 (often written as COXPD14) is a very rare, serious genetic disease that affects how the tiny “power stations” inside our...

    February 19, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)