Bleomycin – Uses, Dosage, Side Effects, Interaction

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 74 min read
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Bleomycin - Uses, Dosage, Side Effects, Interaction
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Bleomycin is a cytotoxic antibiotic that is used as an anticancer agent in the therapy of testicular and germ cell cancers, Hodgkin disease, lymphomas, and tumors of the head and neck. Therapy with bleomycin in combination with other agents is often associated with mild-to-moderate serum...

For severe symptoms, danger signs, pregnancy, child illness, or sudden worsening, seek urgent medical care.

বাংলা রোগী নোট এখনো যোগ করা হয়নি। পোস্ট এডিটরে “RX Bangla Patient Mode” বক্স থেকে সহজ বাংলা সারাংশ যোগ করুন।

এই তথ্য শিক্ষা ও সচেতনতার জন্য। এটি ডাক্তারি পরীক্ষা, রোগ নির্ণয় বা প্রেসক্রিপশনের বিকল্প নয়।

Article Summary

Bleomycin is a cytotoxic antibiotic that is used as an anticancer agent in the therapy of testicular and germ cell cancers, Hodgkin disease, lymphomas, and tumors of the head and neck. Therapy with bleomycin in combination with other agents is often associated with mild-to-moderate serum enzyme elevations but is a rare cause of clinically apparent liver injury. Bleomycin A2 is the primary bleomycin species in bleomycin...

Key Takeaways

  • This article explains Mechanism of Action in simple medical language.
  • This article explains Indications in simple medical language.
  • This article explains Contraindication in simple medical language.
  • This article explains Dosage in simple medical language.
Educational health guideWritten for patient understanding and clinical awareness.
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Emergency safety firstUrgent warning signs are highlighted below.

Seek urgent medical care if you notice

These warning signs are general safety guidance. Local emergency numbers and clinical judgment should always come first.

  • Severe symptoms, breathing difficulty, fainting, confusion, or rapidly worsening illness.
  • New weakness, severe pain, high fever, or symptoms after a serious injury.
  • Any symptom that feels urgent, unusual, or unsafe for the patient.
1

Emergency now

Use emergency care for severe, sudden, rapidly worsening, or life-threatening symptoms.

2

See a doctor

Book a professional medical evaluation if symptoms persist, worsen, recur often, affect daily activities, or occur in a high-risk patient.

3

Learn safely

Use this article to understand possible causes, tests, treatment options, prevention, and questions to ask your clinician.

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Definition

Bleomycin is a cytotoxic bacterial infections. সহজ বাংলা: ব্যাকটেরিয়ার সংক্রমণের ওষুধ।" data-rx-term="antibiotic" data-rx-definition="An antibiotic is a medicine used to treat bacterial infections. সহজ বাংলা: ব্যাকটেরিয়ার সংক্রমণের ওষুধ।">antibiotic that is used as an anticancer agent in the therapy of testicular and germ cell cancers, Hodgkin disease, lymphomas, and tumors of the head and neck. Therapy with bleomycin in combination with other agents is often associated with mild-to-moderate serum enzyme elevations but is a rare cause of clinically apparent liver injury.

Bleomycin A2 is the primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin A2 forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04)

Bleomycin Sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

Mechanism of Action

Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. As evident in _in vitro_ studies, the DNA-cleaving actions of bleomycin are dependent on oxygen and metal ions. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudonym that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.

or

The cytotoxic action of bleomycin results from its ability to cause fragmentation of DNA. Studies in vitro indicate that bleomycin causes the accumulation of cells in the G2 phase of the cell cycle, and many of these cells display chromosomal aberrations, incl chromatid breaks, gaps, and fragments, as well as translocations. Bleomycin appears to cause the scission of DNA by interacting with oxygen and iron(2+). In the presence of oxygen and a reducing agent, such as dithiothreitol, the metallobleomycin complex becomes activated and functions mechanistically as a ferrous oxidase, transferring electrons from iron(2) to molecular oxygen to produce activated species of oxygen. It has also been shown that metallobleomycin complexes can be activated by a reaction with the flavin enzyme, NADPH-cytochrome p450 reductase. Bleomycin binds to DNA through its amino-terminal peptide, and the activated complex generates free radicals that are responsible for the scission of the DNA chain.

Indications

  • For palliative treatment in the management of malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
  • Lymphoma, Hodgkins
  • Non-Hodgkin’s Lymphoma (NHL)
  • Pleural Effusion, Malignant
  • Squamous Cell Carcinoma (SCC)
  • Teratocarcinoma
  • Testicular Choriocarcinoma
  • Testicular Embryonal Carcinoma

Use in Cancer

Bleomycin sulfate is approved to be used alone or with other drugs as palliative treatment of:

Bleomycin sulfate is also approved to treat malignant pleural effusion and keep it from recurring (coming back).

Bleomycin sulfate is also being studied in the treatment of other types of cancer.

Contraindication

  • Hypersensitivity to the active component or any of the ingredients
  • a type of infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation of the lung called interstitial pneumonitis
  • a condition where there is a formation of fibrous tissue in the lung called pulmonary chronic injury or inflammation. সহজ বাংলা: অতিরিক্ত দাগের মতো টিস্যু তৈরি হওয়া।" data-rx-term="fibrosis" data-rx-definition="Fibrosis means excess scar-like tissue formation after chronic injury or inflammation. সহজ বাংলা: অতিরিক্ত দাগের মতো টিস্যু তৈরি হওয়া।">fibrosis
  • pregnancy
  • a patient who is producing milk and breastfeeding
  • chronic obstructive pulmonary disease
  • chronic kidney disease stage 3A (moderate)
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function

Dosage

Strengths: 15 units; 30 units; 15,000 intl units

Squamous Cell Carcinoma

  • 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a week
  • Squamous cell carcinoma sometimes requires 3 weeks before any improvement is noted.
  • When this drug is used in combination with other antineoplastic agents, pulmonary toxicities may occur at lower doses.

Non-Hodgkin’s Lymphoma

  • 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a week
  • Because of the possibility of an anaphylactic reaction, the manufacturer recommends that lymphoma patients be treated with 2 units or less for the first 2 doses. If no acute reaction occurs, then the regular dosage schedule may be followed.

Testicular Cancer

  • 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a weekHodgkin’s Disease
  • 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a week; after a 50% response, a maintenance dose of 1 unit daily or 5 units weekly IV or IM should be given

Malignant Pleural Effusion

  • 60 units administered as a single bolus intrapleural injection
  • When this drug is used in combination with other antineoplastic agents, pulmonary toxicities may occur at lower doses.

Renal Dose Adjustments

The manufacturer recommends the following dose adjustments in patients with renal impairment:

  • CrCl 50 mL/minute or greater: No adjustment is recommended.
  • CrCl 40 to 50 mL/minute: Administer 70% of the normal dose.
  • CrCl 30 to 40 mL/minute: Administer 60% of the normal dose.
  • CrCl 20 to 30 mL/minute: Administer 55% of the normal dose.
  • CrCl 10 to 20 mL/minute: Administer 45% of the normal dose.
  • CrCl 5 to 10 mL/minute: Administer 40% of the normal dose.

Side Effects

The Most Common

  • redness, blistering, pain when an area is touched or pressed. সহজ বাংলা: চাপ দিলে ব্যথা।" data-rx-term="tenderness" data-rx-definition="Tenderness means pain when an area is touched or pressed. সহজ বাংলা: চাপ দিলে ব্যথা।">tenderness, or thickening of the skin
  • darkened skin color
  • rash
  • hair loss
  • sores on the mouth or tongue
  • vomiting
  • loss of appetite
  • weight loss
  • sudden numbness or weakness of the face, arm, or leg on one side of the body
  • sudden confusion or trouble speaking or understanding
  • sudden dizziness. loss of balance or coordination
  • sudden severe pain in the head or upper neck. সহজ বাংলা: মাথাব্যথা।" data-rx-term="headache" data-rx-definition="Headache means pain in the head or upper neck. সহজ বাংলা: মাথাব্যথা।">headache
  • chest pain
  • decreased urination

More Common

  • appetite loss or weight loss
  • changes in fingernails or toenails
  • increased pigmentation of the skin
  • nausea and vomiting
  • skin rash; itching; colored bumps; or peeling of fingertips, elbows, or palms
  • sudden chest pain, shortness of breath, dry cough, tiredness;
  • a light-headed feeling, feeling like you might pass out;
  • loss of appetite, weight loss;
  • sudden numbness or weakness on one side of the body, problems with vision or speech;
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • unusual hardening of your skin; or
  • swelling, numbness, tingling or cold feeling in your fingers.
  • skin redness or tenderness
  • swelling or redness of the hands and feet
  • temporary loss of hair

Rare

  • signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of kidney problems (e.g., decreased urination, nausea, vomiting, swelling of the feet and ankles)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of lung inflammation (e.g., cough, shortness of breath, noisy breathing, decreased blood pressure)
  • sores in mouth and on lips
  • confusion
  • fever and chills occurring within 4 to 10 hours of dose; may last up to 48 hours
  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • sudden and severe chest pain
  • wheezing

Drug Interaction

Pregnancy and Lactation

FDA Pregnancy Category D 

Pregnancy

Studies of this medication have not been done with pregnant women. There is a possibility of birth defects if either the father or mother is using bleomycin at the time of conception, or if it is taken during pregnancy. Effective birth control should be practiced while using this medication. Tell the doctor immediately if you become pregnant while using this medication.

Lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence. Although no data are available to determine an appropriate period to withhold breastfeeding, the drug’s terminal half-life of 4 hours with normal kidney function suggests that withholding breastfeeding for at least 24 hours may be sufficient. This period may be longer in patients with impaired kidney function. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breast milk. Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.

How should this medicine be used?

Bleomycin comes as a powder to be mixed with liquid and injected intravenously (into a vein), intramuscularly (into a muscle), or subcutaneously (under the skin) by a doctor or nurse in a medical office or hospital outpatient department. It is usually injected once or twice a week. When bleomycin is used to treat pleural effusions, it is mixed with liquid and placed in the chest cavity through a chest tube (plastic tube that is placed in the chest cavity through a cut in the skin).

What special precautions should I follow?

Before taking bleomycin,

  • tell your doctor and pharmacist if you are allergic to bleomycin or any of the ingredients in bleomycin injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements, you are taking or plan to take. Your doctor may need to monitor you carefully for side effects.
  • tell your doctor if you have or have ever had kidney or lung disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not become pregnant while you are receiving bleomycin injections. If you become pregnant while receiving bleomycin, call your doctor. Bleomycin may harm the fetus.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving bleomycin.

References

Doctor visit helper

Prepare before seeing a doctor

A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
  • Bring old prescriptions, investigation reports, and current medicines.
  • Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
  • Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

  • What is the most likely cause of my symptoms?
  • Which danger signs mean I should go to hospital quickly?
  • Which tests are necessary now, and which can wait?
  • How should I take medicines safely and what side effects should I watch for?
  • When should I come for follow-up?

Tests to discuss

  • Vital signs: temperature, pulse, blood pressure, oxygen saturation
  • Basic physical examination by a clinician
  • CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

  • Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
  • Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
  • Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Avoid heavy lifting, sudden bending, and prolonged bed rest.
  • Use comfortable posture and gentle movement as tolerated.
  • Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
  • Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Medicine doctor / pediatrician for children / qualified clinician
Tests to discuss with doctor
  • Temperature chart and hydration assessment
  • CBC with platelet count if fever persists or dengue/other infection is possible
  • Urine test, malaria/dengue tests, chest evaluation, or blood culture only when clinically indicated
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?
  • Do I need antibiotics, or is this more likely viral?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Bleomycin – Uses, Dosage, Side Effects, Interaction

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

RX Patient Help

Ask a health question safely

Write your symptom story. A health professional or site editor can review it before any answer is prepared. This box is not for emergency care.

Emergency first: Severe chest pain, breathing trouble, unconsciousness, stroke signs, severe injury, heavy bleeding, or rapidly worsening symptoms need urgent local medical care now.

Frequently Asked Questions

Mechanism of Action Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. As evident in _in vitro_ studies, the DNA-cleaving actions of bleomycin are dependent on oxygen and metal ions. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudonym that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. or The cytotoxic action of bleomycin results from its ability to cause fragmentation of DNA. Studies in vitro indicate that bleomycin causes the accumulation of cells in the G2 phase of the cell cycle, and many of these cells display chromosomal aberrations, incl chromatid breaks, gaps, and fragments, as well as translocations. Bleomycin appears to cause the scission of DNA by interacting with oxygen and iron(2+). In the presence of oxygen and a reducing agent, such as dithiothreitol, the metallobleomycin complex becomes activated and functions mechanistically as a ferrous oxidase, transferring electrons from iron(2) to molecular oxygen to produce activated species of oxygen. It has also been shown that metallobleomycin complexes can be activated by a reaction with the flavin enzyme, NADPH-cytochrome p450 reductase. Bleomycin binds to DNA through its amino-terminal peptide, and the activated complex generates free radicals that are responsible for the scission of the DNA chain. Indications For palliative treatment in the management of malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas. Lymphoma, Hodgkins Non-Hodgkin's Lymphoma (NHL) Pleural Effusion, Malignant Squamous Cell Carcinoma (SCC) Teratocarcinoma Testicular Choriocarcinoma Testicular Embryonal Carcinoma Use in Cancer Bleomycin sulfate is approved to be used alone or with other drugs as palliative treatment of: Hodgkin lymphoma. Non-Hodgkin lymphoma (NHL). Squamous cell carcinoma of the penis. Squamous cell carcinoma of the cervix. Squamous cell carcinoma of the head and neck (SCCHN). Squamous cell carcinoma of the vulva. Testicular cancer. Bleomycin sulfate is also approved to treat malignant pleural effusion and keep it from recurring (coming back). Bleomycin sulfate is also being studied in the treatment of other types of cancer. Contraindication Hypersensitivity to the active component or any of the ingredients a type of inflammation of the lung called interstitial pneumonitis a condition where there is a formation of fibrous tissue in the lung called pulmonary fibrosis pregnancy a patient who is producing milk and breastfeeding chronic obstructive pulmonary disease chronic kidney disease stage 3A (moderate) chronic kidney disease stage 3B (moderate) chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure) kidney disease with likely reduction in kidney function Dosage Strengths: 15 units; 30 units; 15,000 intl units Squamous Cell Carcinoma 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a week Squamous cell carcinoma sometimes requires 3 weeks before any improvement is noted. When this drug is used in combination with other antineoplastic agents, pulmonary toxicities may occur at lower doses. Non-Hodgkin's Lymphoma 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a week Because of the possibility of an anaphylactic reaction, the manufacturer recommends that lymphoma patients be treated with 2 units or less for the first 2 doses. If no acute reaction occurs, then the regular dosage schedule may be followed. Testicular Cancer 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a weekHodgkin's Disease 0.25 to 0.5 units/kg (10 to 20 units/m2) IV, IM, or subcutaneously 1 to 2 times a week; after a 50% response, a maintenance dose of 1 unit daily or 5 units weekly IV or IM should be given Malignant Pleural Effusion 60 units administered as a single bolus intrapleural injection When this drug is used in combination with other antineoplastic agents, pulmonary toxicities may occur at lower doses. Renal Dose Adjustments The manufacturer recommends the following dose adjustments in patients with renal impairment: CrCl 50 mL/minute or greater: No adjustment is recommended. CrCl 40 to 50 mL/minute: Administer 70% of the normal dose. CrCl 30 to 40 mL/minute: Administer 60% of the normal dose. CrCl 20 to 30 mL/minute: Administer 55% of the normal dose. CrCl 10 to 20 mL/minute: Administer 45% of the normal dose. CrCl 5 to 10 mL/minute: Administer 40% of the normal dose. Side Effects The Most Common redness, blistering, tenderness, or thickening of the skin darkened skin color rash hair loss sores on the mouth or tongue vomiting loss of appetite weight loss sudden numbness or weakness of the face, arm, or leg on one side of the body sudden confusion or trouble speaking or understanding sudden dizziness. loss of balance or coordination sudden severe headache chest pain decreased urination More Common appetite loss or weight loss changes in fingernails or toenails increased pigmentation of the skin nausea and vomiting skin rash; itching; colored bumps; or peeling of fingertips, elbows, or palms sudden chest pain, shortness of breath, dry cough, tiredness; a light-headed feeling, feeling like you might pass out; loss of appetite, weight loss; sudden numbness or weakness on one side of the body, problems with vision or speech; blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; unusual hardening of your skin; or swelling, numbness, tingling or cold feeling in your fingers. skin redness or tenderness swelling or redness of the hands and feet temporary loss of hair Rare signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness) signs of kidney problems (e.g., decreased urination, nausea, vomiting, swelling of the feet and ankles) signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools) signs of lung inflammation (e.g., cough, shortness of breath, noisy breathing, decreased blood pressure) sores in mouth and on lips confusion fever and chills occurring within 4 to 10 hours of dose; may last up to 48 hours signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat) sudden and severe chest pain wheezing Drug Interaction DRUG INTERACTION Abacavir Bleomycin may decrease the excretion rate of Abacavir which could result in a higher serum level. Abatacept The risk or severity of adverse effects can be increased when Bleomycin is combined with Abatacept. Aceclofenac Aceclofenac may decrease the excretion rate of Bleomycin which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Acetaminophen Bleomycin may decrease the excretion rate of Acetaminophen which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Acetyldigitoxin Acetyldigitoxin may decrease the cardiotoxic activities of Bleomycin. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Bleomycin which could result in a higher serum level. Aclidinium Bleomycin may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Bleomycin may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Bleomycin which could result in a higher serum level. Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Bleomycin. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Bleomycin which could result in a higher serum level. Adenovirus type 7 The risk or severity of infection can be increased when Adenovirus type 7 vaccine live is combined with Bleomycin. Albutrepenonacog alfa Bleomycin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. Alclofenac Alclofenac may decrease the excretion rate of Bleomycin which could result in a higher serum level. Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Bleomycin. Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Bleomycin. Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Bleomycin. Allogeneic processed The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Bleomycin. Allopurinol Bleomycin may decrease the excretion rate of Allopurinol which could result in a higher serum level. Almasilate Bleomycin may decrease the excretion rate of Almasilate which could result in a higher serum level. Almotriptan Bleomycin may decrease the excretion rate of Almotriptan which could result in a higher serum level. Alogliptin Bleomycin may decrease the excretion rate of Alogliptin which could result in a higher serum level. Alprazolam Bleomycin may decrease the excretion rate of Alprazolam which could result in a higher serum level. Altretamine The risk or severity of adverse effects can be increased when Bleomycin is combined with Altretamine. Amantadine Bleomycin may decrease the excretion rate of Amantadine which could result in a higher serum level. Amikacin Bleomycin may decrease the excretion rate of Amikacin which could result in a higher serum level. Amiloride Amiloride may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Aminophenazone Aminophenazone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Amitriptyline Bleomycin may decrease the excretion rate of Amitriptyline which could result in a higher serum level. Ammonium chloride Bleomycin may decrease the excretion rate of Ammonium chloride which could result in a higher serum level. Amoxicillin Bleomycin may decrease the excretion rate of Amoxicillin which could result in a higher serum level. Amphetamine Amphetamine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Amphotericin B Amphotericin B may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ampicillin Bleomycin may decrease the excretion rate of Ampicillin which could result in a higher serum level. Amrinone Bleomycin may decrease the excretion rate of Amrinone which could result in a higher serum level. Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Bleomycin. Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Bleomycin. Anastrozole The risk or severity of cardiotoxicity can be increased when Bleomycin is combined with Anastrozole. Ancestim Bleomycin may decrease the excretion rate of Ancestim which could result in a higher serum level. Anifrolumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Anifrolumab. Anthrax immune The therapeutic efficacy of Anthrax immune globulin human can be decreased when used in combination with Bleomycin. Anthrax vaccine The risk or severity of infection can be increased when Anthrax vaccine is combined with Bleomycin. Antihemophilic Bleomycin may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level. Antilymphocyte The risk or severity of adverse effects can be increased when Bleomycin is combined with Antilymphocyte immunoglobulin (horse). Antipyrine Antipyrine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Antithrombin III Bleomycin may decrease the excretion rate of Antithrombin III human which could result in a higher serum level. Antithymocyte The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Bleomycin. Antrafenine Antrafenine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Apalutamide Bleomycin may decrease the excretion rate of Apalutamide which could result in a higher serum level. Apremilast The risk or severity of adverse effects can be increased when Bleomycin is combined with Apremilast. Arformoterol Bleomycin may decrease the excretion rate of Arformoterol which could result in a higher serum level. Arsenic trioxide The risk or severity of adverse effects can be increased when Bleomycin is combined with Arsenic trioxide. Articaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Articaine. Ascorbic acid The therapeutic efficacy of Bleomycin can be decreased when used in combination with Ascorbic acid.  COVID-19 Vaccine The therapeutic efficacy of AstraZeneca COVID-19 Vaccine can be decreased when used in combination with Bleomycin. Atazanavir Atazanavir may decrease the excretion rate of Bleomycin which could result in a higher serum level. Atomoxetine Atomoxetine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Auranofin Bleomycin may decrease the excretion rate of Auranofin which could result in a higher serum level. Aurothioglucose Bleomycin may decrease the excretion rate of Aurothioglucose which could result in a higher serum level. Azacitidine The risk or severity of adverse effects can be increased when Bleomycin is combined with Azacitidine. Azathioprine The risk or severity of adverse effects can be increased when Bleomycin is combined with Azathioprine. Azelaic acid Bleomycin may decrease the excretion rate of Azelaic acid which could result in a higher serum level. Aztreonam Bleomycin may decrease the excretion rate of Aztreonam which could result in a higher serum level. Bacillus  antigen The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Bleomycin. Bacillus calmette- The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Bleomycin. Bacillus The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Bleomycin. Bacitracin Bacitracin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Baclofen Baclofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Balsalazide Balsalazide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Baricitinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Baricitinib. Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Bleomycin. BCG vaccine The risk or severity of infection can be increased when BCG vaccine is combined with Bleomycin. Beclomethasone The risk or severity of adverse effects can be increased when Bleomycin is combined with Beclomethasone dipropionate. Belatacept The risk or severity of adverse effects can be increased when Bleomycin is combined with Belatacept. Belimumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Belimumab. Belinostat The risk or severity of adverse effects can be increased when Bleomycin is combined with Belinostat. Belumosudil The risk or severity of adverse effects can be increased when Bleomycin is combined with Belumosudil. Bendamustine The risk or severity of adverse effects can be increased when Bleomycin is combined with Bendamustine. Bendroflumethiazide Bendroflumethiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Benorilate Benorilate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Benoxaprofen Benoxaprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Benserazide Bleomycin may decrease the excretion rate of Benserazide which could result in a higher serum level. Benzatropine Benzatropine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Benznidazole Bleomycin may decrease the excretion rate of Benznidazole which could result in a higher serum level. Benzocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Benzocaine. Benzthiazide Benzthiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Benzydamine Benzydamine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Benzyl alcohol. Bepotastine Bleomycin may decrease the excretion rate of Bepotastine which could result in a higher serum level. Betamethasone The risk or severity of adverse effects can be increased when Bleomycin is combined with Betamethasone. Bevacizumab The risk or severity of cardiotoxicity can be increased when Bevacizumab is combined with Bleomycin. Bexarotene The risk or severity of adverse effects can be increased when Bleomycin is combined with Bexarotene. Bicisate Bleomycin may decrease the excretion rate of Bicisate which could result in a higher serum level. Bimekizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Bimekizumab. Bismuth subgallate Bleomycin may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. Bisoprolol Bleomycin may decrease the excretion rate of Bisoprolol which could result in a higher serum level. Bisoxatin Bleomycin may decrease the excretion rate of Bisoxatin which could result in a higher serum level. Blinatumomab The risk or severity of adverse effects can be increased when Bleomycin is combined with Blinatumomab. Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Bleomycin. Bosutinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Bosutinib. Brentuximab vedotin The risk or severity of pulmonary toxicity can be increased when Brentuximab vedotin is combined with Bleomycin. Brivaracetam Bleomycin may decrease the excretion rate of Brivaracetam which could result in a higher serum level. Brodalumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Brodalumab. Bromazepam Bleomycin may decrease the excretion rate of Bromazepam which could result in a higher serum level. Bromotheophylline Bromotheophylline may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Budesonide The risk or severity of adverse effects can be increased when Bleomycin is combined with Budesonide. Bumadizone Bumadizone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Bumetanide Bumetanide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Bupivacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Bupivacaine. Bupropion Bleomycin may decrease the excretion rate of Bupropion which could result in a higher serum level. Buspirone Bleomycin may decrease the excretion rate of Buspirone which could result in a higher serum level. Busulfan The risk or severity of adverse effects can be increased when Bleomycin is combined with Busulfan. Butabarbital Butabarbital may decrease the excretion rate of Bleomycin which could result in a higher serum level. Butacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Butacaine. Butamben The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Butamben. Cabazitaxel The risk or severity of adverse effects can be increased when Bleomycin is combined with Cabazitaxel. Calcium ascorbate The therapeutic efficacy of Bleomycin can be decreased when used in combination with Calcium ascorbate. Canagliflozin Canagliflozin may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Canakinumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Canakinumab. Canrenoic Canrenoic acid may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Capecitabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Capecitabine. Capreomycin Bleomycin may decrease the excretion rate of Capreomycin which could result in a higher serum level. Capsaicin The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Capsaicin. Carbamazepine The risk or severity of adverse effects can be increased when Bleomycin is combined with Carbamazepine. Carbidopa Carbidopa may decrease the excretion rate of Bleomycin which could result in a higher serum level. Carboplatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Carboplatin. Carfilzomib The risk or severity of adverse effects can be increased when Bleomycin is combined with Carfilzomib. Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Bleomycin. Carprofen Carprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefaclor Cefaclor may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefadroxil Cefadroxil may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefalotin Cefalotin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefamandole Cefamandole may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefapirin Cefapirin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefazolin Cefazolin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefdinir Bleomycin may decrease the excretion rate of Cefdinir which could result in a higher serum level. Cefditoren Cefditoren may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefepime Cefepime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefmenoxime Cefmenoxime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefmetazole Cefmetazole may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefonicid Cefonicid may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefoperazone Cefoperazone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceforanide Ceforanide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefotaxime Cefotaxime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefotetan Cefotetan may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefotiam Cefotiam may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefoxitin Cefoxitin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefpiramide Cefpiramide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefpirome Cefpirome may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefpodoxime Cefpodoxime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefprozil Cefprozil may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefradine Cefradine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceftazidime Ceftazidime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceftibuten Ceftibuten may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceftizoxime Ceftizoxime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceftobiprole Ceftobiprole may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ceftolozane Bleomycin may decrease the excretion rate of Ceftolozane which could result in a higher serum level. Ceftriaxone Ceftriaxone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cefuroxime Cefuroxime may decrease the excretion rate of Bleomycin which could result in a higher serum level. Celecoxib Celecoxib may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cephalexin Cephalexin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cephaloglycin Cephaloglycin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Certolizumab pegol The risk or severity of adverse effects can be increased when Bleomycin is combined with Certolizumab pegol. Cetirizine Bleomycin may decrease the excretion rate of Cetirizine which could result in a higher serum level. Cevimeline Cevimeline may decrease the excretion rate of Bleomycin which could result in a higher serum level. Chloral hydrate Bleomycin may decrease the excretion rate of Chloral hydrate which could result in a higher serum level. Chlorambucil The risk or severity of adverse effects can be increased when Bleomycin is combined with Chlorambucil. Chloramphenicol The risk or severity of adverse effects can be increased when Bleomycin is combined with Chloramphenicol. Chloroprocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Chloroprocaine. Chloroquine Bleomycin may decrease the excretion rate of Chloroquine which could result in a higher serum level. Chlorothiazide Chlorothiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Chloroxylenol Bleomycin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. Chlorpromazine Bleomycin may decrease the excretion rate of Chlorpromazine which could result in a higher serum level. Chlorpropamide Bleomycin may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. Chlorthalidone Chlorthalidone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Chlorzoxazone Bleomycin may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level. Choline C 11 Bleomycin may decrease the excretion rate of Choline C 11 which could result in a higher serum level. Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Choline salicylate Bleomycin may decrease the excretion rate of Choline salicylate which could result in a higher serum level. Chondroitin sulfate Bleomycin may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Chromic chloride Bleomycin may decrease the excretion rate of Chromic chloride which could result in a higher serum level. Chromic nitrate Bleomycin may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. Chromium Bleomycin may decrease the excretion rate of Chromium which could result in a higher serum level. Chromium gluconate Bleomycin may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. Chromium nicotinate Bleomycin may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. Chromous sulfate Bleomycin may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. Ciclesonide The risk or severity of adverse effects can be increased when Bleomycin is combined with Ciclesonide. Cidofovir Cidofovir may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cilostazol Bleomycin may decrease the excretion rate of Cilostazol which could result in a higher serum level. Cimetidine Bleomycin may decrease the excretion rate of Cimetidine which could result in a higher serum level. Cinchocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Cinchocaine. Ciprofloxacin Bleomycin may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level. Cisplatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Cisplatin. Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Bleomycin. Clevidipine Bleomycin may decrease the excretion rate of Clevidipine which could result in a higher serum level. Clobazam Bleomycin may decrease the excretion rate of Clobazam which could result in a higher serum level. Clobetasol propionate The risk or severity of adverse effects can be increased when Bleomycin is combined with Clobetasol propionate. Clofarabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Clofarabine. Clomipramine Bleomycin may decrease the excretion rate of Clomipramine which could result in a higher serum level. Clonazepam Bleomycin may decrease the excretion rate of Clonazepam which could result in a higher serum level. Clorazepic acid Bleomycin may decrease the excretion rate of Clorazepic acid which could result in a higher serum level. Clostridium tetani The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Bleomycin. Clove oil Bleomycin may decrease the excretion rate of Clove oil which could result in a higher serum level. Clozapine Bleomycin may decrease the excretion rate of Clozapine which could result in a higher serum level. Cocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Cocaine. Colchicine Bleomycin may decrease the excretion rate of Colchicine which could result in a higher serum level. Colistimethate Colistimethate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Colistin Bleomycin may decrease the excretion rate of Colistin which could result in a higher serum level. Conivaptan Conivaptan may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Conjugated estrogens Conjugated estrogens may decrease the excretion rate of Bleomycin which could result in a higher serum level. Corifollitropin alfa Bleomycin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. Corticotropin The risk or severity of adverse effects can be increased when Bleomycin is combined with Corticotropin. Cortisone acetate The risk or severity of adverse effects can be increased when Bleomycin is combined with Cortisone acetate. Corynebacterium The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Bleomycin. Cyanocobalamin Cyanocobalamin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Cyclopenthiazide Cyclopenthiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Cyclophosphamide The risk or severity of adverse effects can be increased when Bleomycin is combined with Cyclophosphamide. Cyclosporine Bleomycin may increase the immunosuppressive activities of Cyclosporine. Cyclothiazide Cyclothiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Cytarabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Cytarabine. Dabigatran etexilate Bleomycin may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level. Dacarbazine The risk or severity of adverse effects can be increased when Bleomycin is combined with Dacarbazine. Dactinomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Dactinomycin. Dalfampridine Bleomycin may decrease the excretion rate of Dalfampridine which could result in a higher serum level. Dapagliflozin Dapagliflozin may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Daptomycin Daptomycin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bleomycin. Dasatinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Dasatinib. Daunorubicin The risk or severity of adverse effects can be increased when Bleomycin is combined with Daunorubicin. Decitabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Decitabine. Deferiprone Bleomycin may decrease the excretion rate of Deferiprone which could result in a higher serum level. Deflazacort The risk or severity of adverse effects can be increased when Bleomycin is combined with Deflazacort. Delafloxacin Bleomycin may decrease the excretion rate of Delafloxacin which could result in a higher serum level. Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Bleomycin. Desipramine Bleomycin may decrease the excretion rate of Desipramine which could result in a higher serum level. Deslanoside Deslanoside may decrease the cardiotoxic activities of Bleomycin. Desmopressin Desmopressin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Desoximetasone The risk or severity of adverse effects can be increased when Bleomycin is combined with Desoximetasone. Desvenlafaxine Bleomycin may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level. Deucravacitinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Deucravacitinib. Deutetrabenazine Bleomycin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. Dexamethasone The risk or severity of adverse effects can be increased when Bleomycin is combined with Dexamethasone. Dexibuprofen Dexibuprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Dexketoprofen Dexketoprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Dexmedetomidine Bleomycin may decrease the excretion rate of Dexmedetomidine which could result in a higher serum level. Dexpanthenol Bleomycin may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Dexrazoxane The risk or severity of adverse effects can be increased when Bleomycin is combined with Dexrazoxane. Dextran Bleomycin may decrease the excretion rate of Dextran which could result in a higher serum level. Diatrizoate Diatrizoate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Diazepam Bleomycin may decrease the excretion rate of Diazepam which could result in a higher serum level. Dichlorobenzyl alcohol Bleomycin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. Diclofenac Diclofenac may decrease the excretion rate of Bleomycin which could result in a higher serum level. Diclofenamide Diclofenamide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Dicyclomine Bleomycin may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Didanosine Bleomycin may decrease the excretion rate of Didanosine which could result in a higher serum level. Dienogest Bleomycin may decrease the excretion rate of Dienogest which could result in a higher serum level. Diflunisal Diflunisal may decrease the excretion rate of Bleomycin which could result in a higher serum level. Difluocortolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Difluocortolone. Digitoxin Digitoxin may decrease the cardiotoxic activities of Bleomycin. Digoxin Bleomycin may decrease the excretion rate of Digoxin which could result in a higher serum level. Dihydrostreptomycin Dihydrostreptomycin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Dimercaprol Bleomycin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. Dimethyl fumarate The risk or severity of adverse effects can be increased when Bleomycin is combined with Dimethyl fumarate. Dimethyl sulfoxide Bleomycin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level. Dinutuximab The risk or severity of adverse effects can be increased when Bleomycin is combined with Dinutuximab. Diphenhydramine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Diphenhydramine. Diroximel fumarate The risk or severity of adverse effects can be increased when Bleomycin is combined with Diroximel fumarate. Disopyramide Disopyramide may decrease the excretion rate of Bleomycin which could result in a higher serum level. DL-Methylephedrine Bleomycin may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level. Dobutamine Bleomycin may decrease the excretion rate of Dobutamine which could result in a higher serum level. Docetaxel The risk or severity of adverse effects can be increased when Bleomycin is combined with Docetaxel. Dopamine Bleomycin may decrease the excretion rate of Dopamine which could result in a higher serum level. Doripenem Bleomycin may decrease the excretion rate of Doripenem which could result in a higher serum level. Doxacurium Bleomycin may decrease the excretion rate of Doxacurium which could result in a higher serum level. Doxepin Bleomycin may decrease the excretion rate of Doxepin which could result in a higher serum level. Doxorubicin The risk or severity of adverse effects can be increased when Bleomycin is combined with Doxorubicin. Doxycycline Doxycycline may decrease the excretion rate of Bleomycin which could result in a higher serum level. Drospirenone Drospirenone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Droxidopa Bleomycin may decrease the excretion rate of Droxidopa which could result in a higher serum level. Duloxetine Bleomycin may decrease the excretion rate of Duloxetine which could result in a higher serum level. Dyclonine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Dyclonine. Dyphylline Bleomycin may decrease the excretion rate of Dyphylline which could result in a higher serum level. Ebola The therapeutic efficacy of Ebola Zaire vaccine (live, attenuated) can be decreased when used in combination with Bleomycin. Eculizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Eculizumab. Edoxaban Bleomycin may decrease the excretion rate of Edoxaban which could result in a higher serum level. Edrophonium Bleomycin may decrease the excretion rate of Edrophonium which could result in a higher serum level. Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Bleomycin. Emapalumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Emapalumab. Enalaprilat Bleomycin may decrease the excretion rate of Enalaprilat which could result in a higher serum level. Enzalutamide Bleomycin may decrease the excretion rate of Enzalutamide which could result in a higher serum level. Epirubicin The risk or severity of adverse effects can be increased when Bleomycin is combined with Epirubicin. Eplerenone Eplerenone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Epoprostenol Bleomycin may decrease the excretion rate of Epoprostenol which could result in a higher serum level. Eribulin The risk or severity of adverse effects can be increased when Bleomycin is combined with Eribulin. Ertapenem Bleomycin may decrease the excretion rate of Ertapenem which could result in a higher serum level. Ertugliflozin Ertugliflozin may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Estradiol Bleomycin may decrease the excretion rate of Estradiol which could result in a higher serum level. Estradiol acetate Bleomycin may decrease the excretion rate of Estradiol acetate which could result in a higher serum level. Estradiol cypionate Bleomycin may decrease the excretion rate of Estradiol cypionate which could result in a higher serum level. Estradiol dienanthate Bleomycin may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level. Estradiol valerate Bleomycin may decrease the excretion rate of Estradiol valerate which could result in a higher serum level. Estramustine The risk or severity of adverse effects can be increased when Bleomycin is combined with Estramustine. Estrone sulfate Bleomycin may decrease the excretion rate of Estrone sulfate which could result in a higher serum level. Eszopiclone Bleomycin may decrease the excretion rate of Eszopiclone which could result in a higher serum level. Etacrynic acid Etacrynic acid may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Etafedrine Bleomycin may decrease the excretion rate of Etafedrine which could result in a higher serum level. Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Bleomycin. Ethambutol Bleomycin may decrease the excretion rate of Ethambutol which could result in a higher serum level. Ethyl chloride The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Ethyl chloride. Etidocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Etidocaine. Etodolac Etodolac may decrease the excretion rate of Bleomycin which could result in a higher serum level. Etomidate Bleomycin may decrease the excretion rate of Etomidate which could result in a higher serum level. Etonogestrel Bleomycin may decrease the excretion rate of Etonogestrel which could result in a higher serum level. Etoposide The risk or severity of adverse effects can be increased when Bleomycin is combined with Etoposide. Etoricoxib Etoricoxib may decrease the excretion rate of Bleomycin which could result in a higher serum level. Eucalyptus oil Bleomycin may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. Everolimus The risk or severity of adverse effects can be increased when Bleomycin is combined with Everolimus. Ezogabine Bleomycin may decrease the excretion rate of Ezogabine which could result in a higher serum level. Fenbufen Fenbufen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Fenofibrate Bleomycin may decrease the excretion rate of Fenofibrate which could result in a higher serum level. Fenofibric acid Bleomycin may decrease the excretion rate of Fenofibric acid which could result in a higher serum level. Fenoldopam Bleomycin may decrease the excretion rate of Fenoldopam which could result in a higher serum level. Fenoprofen Fenoprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Fentanyl Bleomycin may decrease the excretion rate of Fentanyl which could result in a higher serum level. Fesoterodine Bleomycin may decrease the excretion rate of Fesoterodine which could result in a higher serum level. Filgotinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Filgotinib. Filgrastim The risk or severity of pulmonary toxicity can be increased when Filgrastim is combined with Bleomycin. Finerenone Finerenone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Fingolimod Bleomycin may increase the immunosuppressive activities of Fingolimod. Flavoxate Bleomycin may decrease the excretion rate of Flavoxate which could result in a higher serum level. Floctafenine Floctafenine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Florbetaben (18F) Bleomycin may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level. Florbetapir (18F) Bleomycin may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level. Floxuridine The risk or severity of adverse effects can be increased when Bleomycin is combined with Floxuridine. Fluconazole Fluconazole may decrease the excretion rate of Bleomycin which could result in a higher serum level. Flucytosine The risk or severity of adverse effects can be increased when Bleomycin is combined with Flucytosine. Fludarabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Fludarabine. Fludeoxyglucose (18F) Bleomycin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level. Fludrocortisone The risk or severity of adverse effects can be increased when Bleomycin is combined with Fludrocortisone. Flumazenil Bleomycin may decrease the excretion rate of Flumazenil which could result in a higher serum level. Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Bleomycin. Fluocinolone acetonide The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluocinolone acetonide. Fluocinonide The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluocinonide. Fluocortolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluocortolone. Fluorometholone The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluorometholone. Fluorouracil The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluorouracil. Fluprednisolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluprednisolone. Flurazepam Bleomycin may decrease the excretion rate of Flurazepam which could result in a higher serum level. Flurbiprofen Flurbiprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Flutamide Bleomycin may decrease the excretion rate of Flutamide which could result in a higher serum level. Fluticasone The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluticasone. Fluticasone furoate The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluticasone furoate. Fluticasone propionate The risk or severity of adverse effects can be increased when Bleomycin is combined with Fluticasone propionate. Fluvoxamine Fluvoxamine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Folic acid Folic acid may decrease the excretion rate of Bleomycin which could result in a higher serum level. Fomepizole Bleomycin may decrease the excretion rate of Fomepizole which could result in a higher serum level. Fondaparinux Bleomycin may decrease the excretion rate of Fondaparinux which could result in a higher serum level. Formestane Bleomycin may decrease the excretion rate of Formestane which could result in a higher serum level. Foscarnet Foscarnet may decrease the excretion rate of Bleomycin which could result in a higher serum level. Fosfomycin Bleomycin may decrease the excretion rate of Fosfomycin which could result in a higher serum level. Fosinopril Bleomycin may decrease the excretion rate of Fosinopril which could result in a higher serum level. Fosphenytoin The serum concentration of Fosphenytoin can be decreased when it is combined with Bleomycin. Framycetin Framycetin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Furosemide Furosemide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Gabapentin enacarbil Bleomycin may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level. Gadobenic acid Bleomycin may decrease the excretion rate of Gadobenic acid which could result in a higher serum level. Gadodiamide Gadodiamide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Gadofosveset trisodium Bleomycin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level. Gadopentetic acid Bleomycin may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level. Gadoteric acid Bleomycin may decrease the excretion rate of Gadoteric acid which could result in a higher serum level. Gadoteridol Bleomycin may decrease the excretion rate of Gadoteridol which could result in a higher serum level. Gallium nitrate The risk or severity of adverse effects can be increased when Bleomycin is combined with Gallium nitrate. Ganciclovir Bleomycin may decrease the excretion rate of Ganciclovir which could result in a higher serum level. Gemcitabine The risk or severity of pulmonary toxicity can be increased when Gemcitabine is combined with Bleomycin. Gemfibrozil Bleomycin may decrease the excretion rate of Gemfibrozil which could result in a higher serum level. Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Bleomycin. Gentamicin Bleomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level. Gimeracil Bleomycin may decrease the excretion rate of Gimeracil which could result in a higher serum level. Givosiran Givosiran may decrease the excretion rate of Bleomycin which could result in a higher serum level. Glatiramer The risk or severity of adverse effects can be increased when Bleomycin is combined with Glatiramer. Glipizide Bleomycin may decrease the excretion rate of Glipizide which could result in a higher serum level. Glycerol phenylbutyrate Bleomycin may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level. Golimumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Golimumab. Golodirsen Bleomycin may decrease the excretion rate of Golodirsen which could result in a higher serum level. Goserelin Goserelin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Guanethidine Bleomycin may decrease the excretion rate of Guanethidine which could result in a higher serum level. Guanfacine Bleomycin may decrease the excretion rate of Guanfacine which could result in a higher serum level. Guselkumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Guselkumab. Iopromide Bleomycin may decrease the excretion rate of Iopromide which could result in a higher serum level. Iothalamic acid Bleomycin may decrease the excretion rate of Iothalamic acid which could result in a higher serum level. Ioversol Bleomycin may decrease the excretion rate of Ioversol which could result in a higher serum level. Ioxilan Bleomycin may decrease the excretion rate of Ioxilan which could result in a higher serum level. Ipecac Bleomycin may decrease the excretion rate of Ipecac which could result in a higher serum level. Ipilimumab Bleomycin may decrease the excretion rate of Ipilimumab which could result in a higher serum level. Irinotecan The risk or severity of adverse effects can be increased when Bleomycin is combined with Irinotecan. Isoniazid Bleomycin may decrease the excretion rate of Isoniazid which could result in a higher serum level. Isosorbide Isosorbide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Isosorbide mononitrate Bleomycin may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. Isosulfan blue Bleomycin may decrease the excretion rate of Isosulfan blue which could result in a higher serum level. Isotretinoin Bleomycin may decrease the excretion rate of Isotretinoin which could result in a higher serum level. Isoxicam Isoxicam may decrease the excretion rate of Bleomycin which could result in a higher serum level. Isradipine Isradipine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ixabepilone The risk or severity of adverse effects can be increased when Bleomycin is combined with Ixabepilone. Ixazomib Bleomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. Ixekizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Ixekizumab. COVID-19 Vaccine The therapeutic efficacy of Janssen COVID-19 Vaccine can be decreased when used in combination with Bleomycin. Japanese encephalitis The therapeutic efficacy of Japanese encephalitis virus strain sa 14-14-2 antigen (formaldehyde inactivated) can be decreased when used in combination with Bleomycin. Kanamycin Bleomycin may decrease the excretion rate of Kanamycin which could result in a higher serum level. Ketamine Bleomycin may decrease the excretion rate of Ketamine which could result in a higher serum level. Ketazolam Bleomycin may decrease the excretion rate of Ketazolam which could result in a higher serum level. Ketoprofen Ketoprofen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ketorolac Ketorolac may decrease the excretion rate of Bleomycin which could result in a higher serum level. Labetalol Bleomycin may decrease the excretion rate of Labetalol which could result in a higher serum level. Lamivudine Bleomycin may decrease the excretion rate of Lamivudine which could result in a higher serum level. Lamotrigine Bleomycin may decrease the excretion rate of Lamotrigine which could result in a higher serum level. Latamoxef Latamoxef may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ledipasvir Bleomycin may decrease the excretion rate of Ledipasvir which could result in a higher serum level. Leflunomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Leflunomide. Lenalidomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Lenalidomide. Lesinurad Bleomycin may decrease the excretion rate of Lesinurad which could result in a higher serum level. Leuprolide Leuprolide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Levobupivacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Levobupivacaine. Levocarnitine Bleomycin may decrease the excretion rate of Levocarnitine which could result in a higher serum level. Levocetirizine Bleomycin may decrease the excretion rate of Levocetirizine which could result in a higher serum level. Levofloxacin Bleomycin may decrease the excretion rate of Levofloxacin which could result in a higher serum level. Levomilnacipran Bleomycin may decrease the excretion rate of Levomilnacipran which could result in a higher serum level. Levosalbutamol Bleomycin may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. Lidocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Lidocaine. Linezolid The risk or severity of adverse effects can be increased when Bleomycin is combined with Linezolid. Liothyronine Liothyronine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Lisinopril Bleomycin may decrease the excretion rate of Lisinopril which could result in a higher serum level. Lithium carbonate Bleomycin may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. Lithium citrate Lithium citrate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Meperidine Bleomycin may decrease the excretion rate of Meperidine which could result in a higher serum level. Mepivacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Mepivacaine. Mepolizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Mepolizumab. Meprednisone The risk or severity of adverse effects can be increased when Bleomycin is combined with Meprednisone. Mercaptopurine The risk or severity of adverse effects can be increased when Bleomycin is combined with Mercaptopurine. Meropenem Bleomycin may decrease the excretion rate of Meropenem which could result in a higher serum level. Mesalazine Mesalazine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Metamfetamine Bleomycin may decrease the excretion rate of Metamfetamine which could result in a higher serum level. Metamizole Metamizole may decrease the excretion rate of Bleomycin which could result in a higher serum level. Metaxalone Bleomycin may decrease the excretion rate of Metaxalone which could result in a higher serum level. Metformin Bleomycin may decrease the excretion rate of Metformin which could result in a higher serum level. Methadone Bleomycin may decrease the excretion rate of Methadone which could result in a higher serum level. Methazolamide Methazolamide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Methimazole The risk or severity of adverse effects can be increased when Bleomycin is combined with Methimazole. Methotrexate The risk or severity of adverse effects can be increased when Bleomycin is combined with Methotrexate. Methoxsalen Bleomycin may decrease the excretion rate of Methoxsalen which could result in a higher serum level. Methoxy polyethylene The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bleomycin. Methyldopa Bleomycin may decrease the excretion rate of Methyldopa which could result in a higher serum level. Methylene blue Bleomycin may decrease the excretion rate of Methylene blue which could result in a higher serum level. Methylnaltrexone Bleomycin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. Methylprednisolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Methylprednisolone. Methyltestosterone Bleomycin may decrease the excretion rate of Methyltestosterone which could result in a higher serum level. Meticrane Meticrane may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Metoclopramide Bleomycin may decrease the excretion rate of Metoclopramide which could result in a higher serum level. Metolazone Metolazone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Metoprolol Metoprolol may decrease the excretion rate of Bleomycin which could result in a higher serum level. Metyrapone Bleomycin may decrease the excretion rate of Metyrapone which could result in a higher serum level. Midazolam Bleomycin may decrease the excretion rate of Midazolam which could result in a higher serum level. Migalastat Bleomycin may decrease the excretion rate of Migalastat which could result in a higher serum level. Milnacipran Bleomycin may decrease the excretion rate of Milnacipran which could result in a higher serum level. Milrinone Milrinone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Mirabegron Bleomycin may decrease the excretion rate of Mirabegron which could result in a higher serum level. Mitomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Mitomycin. Mitoxantrone The risk or severity of adverse effects can be increased when Bleomycin is combined with Mitoxantrone. COVID-19 Vaccine The therapeutic efficacy of Moderna COVID-19 Vaccine can be decreased when used in combination with Bleomycin.  vaccinia Ankara The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Bleomycin. Mometasone furoate The risk or severity of adverse effects can be increased when Bleomycin is combined with Mometasone furoate. Monomethyl fumarate The risk or severity of adverse effects can be increased when Bleomycin is combined with Monomethyl fumarate. Mosunetuzumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Mosunetuzumab. Moxisylyte Bleomycin may decrease the excretion rate of Moxisylyte which could result in a higher serum level. Mumps virus strain B The therapeutic efficacy of Mumps virus strain B level jeryl lynn live antigen can be decreased when used in combination with Bleomycin. Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Bleomycin. Muzolimine Muzolimine may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Mycophenolate mofetil The risk or severity of adverse effects can be increased when Bleomycin is combined with Mycophenolate mofetil. Mycophenolic acid The risk or severity of adverse effects can be increased when Bleomycin is combined with Mycophenolic acid. N-acetyltyrosine Bleomycin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. Nabumetone Nabumetone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Nadolol Bleomycin may decrease the excretion rate of Nadolol which could result in a higher serum level. Naldemedine Bleomycin may decrease the excretion rate of Naldemedine which could result in a higher serum level. Nalmefene Bleomycin may decrease the excretion rate of Nalmefene which could result in a higher serum level. Naloxone Bleomycin may decrease the excretion rate of Naloxone which could result in a higher serum level. Naproxen Naproxen may decrease the excretion rate of Bleomycin which could result in a higher serum level. Natalizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Natalizumab. Nateglinide Bleomycin may decrease the excretion rate of Nateglinide which could result in a higher serum level. Nedaplatin Bleomycin may decrease the excretion rate of Nedaplatin which could result in a higher serum level. Nedocromil Bleomycin may decrease the excretion rate of Nedocromil which could result in a higher serum level. Nefazodone Bleomycin may decrease the excretion rate of Nefazodone which could result in a higher serum level. Nelarabine The risk or severity of adverse effects can be increased when Bleomycin is combined with Nelarabine. Neomycin Bleomycin may decrease the excretion rate of Neomycin which could result in a higher serum level. Netilmicin Bleomycin may decrease the excretion rate of Netilmicin which could result in a higher serum level. Niacinamide The therapeutic efficacy of Bleomycin can be decreased when used in combination with Niacinamide ascorbate. Nicorandil Bleomycin may decrease the excretion rate of Nicorandil which could result in a higher serum level. Nifedipine Bleomycin may decrease the excretion rate of Nifedipine which could result in a higher serum level. Nilotinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Nilotinib. Nilutamide Bleomycin may decrease the excretion rate of Nilutamide which could result in a higher serum level. Nimesulide Nimesulide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Nisoldipine Bleomycin may decrease the excretion rate of Nisoldipine which could result in a higher serum level. Nitric Oxide Bleomycin may decrease the excretion rate of Nitric Oxide which could result in a higher serum level. Nitrofurantoin Bleomycin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. Obinutuzumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Obinutuzumab. Ocrelizumab Ocrelizumab may increase the immunosuppressive activities of Bleomycin. Octinoxate Bleomycin may decrease the excretion rate of Octinoxate which could result in a higher serum level. Ofatumumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Ofatumumab. Olaparib The risk or severity of adverse effects can be increased when Bleomycin is combined with Olaparib. Olsalazine Olsalazine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Opium Bleomycin may decrease the excretion rate of Opium which could result in a higher serum level. Oseltamivir Oseltamivir may decrease the excretion rate of Bleomycin which could result in a higher serum level. Ouabain Ouabain may decrease the cardiotoxic activities of Bleomycin. Oxacillin Bleomycin may decrease the excretion rate of Oxacillin which could result in a higher serum level. Oxaliplatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Oxaliplatin. Oxaprozin Oxaprozin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Oxazepam Bleomycin may decrease the excretion rate of Oxazepam which could result in a higher serum level. Oxetacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Oxetacaine. Oxybenzone Bleomycin may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Oxybuprocaine. Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Oxyquinoline Bleomycin may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. Ozanimod The risk or severity of adverse effects can be increased when Bleomycin is combined with Ozanimod. Paclitaxel The risk or severity of adverse effects can be increased when Bleomycin is combined with Paclitaxel. Palbociclib The risk or severity of adverse effects can be increased when Bleomycin is combined with Palbociclib. Paliperidone Bleomycin may decrease the excretion rate of Paliperidone which could result in a higher serum level. Palonosetron Bleomycin may decrease the excretion rate of Palonosetron which could result in a higher serum level. Pamidronic acid Pamidronic acid may decrease the excretion rate of Bleomycin which could result in a higher serum level. Panobinostat The risk or severity of adverse effects can be increased when Bleomycin is combined with Panobinostat. Pantoprazole Pantoprazole may decrease the excretion rate of Bleomycin which could result in a higher serum level. Parecoxib Parecoxib may decrease the excretion rate of Bleomycin which could result in a higher serum level. Paromomycin Paromomycin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Patent Blue Bleomycin may decrease the excretion rate of Patent Blue which could result in a higher serum level. Pazopanib The risk or severity of adverse effects can be increased when Bleomycin is combined with Pazopanib. Pegaptanib Bleomycin may decrease the excretion rate of Pegaptanib which could result in a higher serum level. Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Bleomycin. Pegcetacoplan The risk or severity of adverse effects can be increased when Bleomycin is combined with Pegcetacoplan. Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Bleomycin. Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Bleomycin. Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Bleomycin. Peginterferon beta-1a The risk or severity of adverse effects can be increased when Bleomycin is combined with Peginterferon beta-1a. Pemetrexed The risk or severity of adverse effects can be increased when Bleomycin is combined with Pemetrexed. Penbutolol Bleomycin may decrease the excretion rate of Penbutolol which could result in a higher serum level. Penicillamine The risk or severity of adverse effects can be increased when Bleomycin is combined with Penicillamine. Pentaerythritol tetranitrate Bleomycin may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level. Pentamidine Pentamidine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Pentastarch Bleomycin may decrease the excretion rate of Pentastarch which could result in a higher serum level. Pentetic acid Bleomycin may decrease the excretion rate of Pentetic acid which could result in a higher serum level. Pentobarbital Bleomycin may decrease the excretion rate of Pentobarbital which could result in a higher serum level. Pentostatin The risk or severity of adverse effects can be increased when Bleomycin is combined with Pentostatin. Pentoxifylline Bleomycin may decrease the excretion rate of Pentoxifylline which could result in a higher serum level. Perindopril Bleomycin may decrease the excretion rate of Perindopril which could result in a higher serum level. Permethrin Bleomycin may decrease the excretion rate of Permethrin which could result in a higher serum level. Pertussis vaccine The therapeutic efficacy of Pertussis vaccine can be decreased when used in combination with Bleomycin. Pertuzumab The risk or severity of cardiotoxicity can be increased when Bleomycin is combined with Pertuzumab. Phenazopyridine Phenazopyridine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Phenelzine Bleomycin may decrease the excretion rate of Phenelzine which could result in a higher serum level. Phenol The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Phenol. Phentolamine Bleomycin may decrease the excretion rate of Phentolamine which could result in a higher serum level. Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Bleomycin. Phenylbutazone Phenylbutazone may decrease the excretion rate of Bleomycin which could result in a higher serum level. Phenytoin The serum concentration of Phenytoin can be decreased when it is combined with Bleomycin. Pholcodine Bleomycin may decrease the excretion rate of Pholcodine which could result in a higher serum level. Phosphoric acid Bleomycin may decrease the excretion rate of Phosphoric acid which could result in a higher serum level. Phylloquinone Bleomycin may decrease the excretion rate of Phylloquinone which could result in a higher serum level. Picosulfuric acid Bleomycin may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level. Pimecrolimus The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Bleomycin. Pindolol Bleomycin may decrease the excretion rate of Pindolol which could result in a higher serum level. Piperacillin Bleomycin may decrease the excretion rate of Piperacillin which could result in a higher serum level. Piracetam Bleomycin may decrease the excretion rate of Piracetam which could result in a higher serum level. Piretanide Piretanide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Pirfenidone The risk or severity of adverse effects can be increased when Bleomycin is combined with Pirfenidone. Piroxicam Piroxicam may decrease the excretion rate of Bleomycin which could result in a higher serum level. Pitolisant Bleomycin may decrease the excretion rate of Pitolisant which could result in a higher serum level. Plazomicin Bleomycin may decrease the excretion rate of Plazomicin which could result in a higher serum level. Plerixafor Bleomycin may decrease the excretion rate of Plerixafor which could result in a higher serum level. Polythiazide Polythiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Pomalidomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Pomalidomide. Ponatinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Ponatinib. Ponesimod The risk or severity of adverse effects can be increased when Bleomycin is combined with Ponesimod. Potassium Potassium may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Potassium acetate Bleomycin may decrease the excretion rate of Potassium acetate which could result in a higher serum level. Potassium bicarbonate Bleomycin may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. Potassium cation Potassium cation may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Potassium chloride Bleomycin may decrease the excretion rate of Potassium chloride which could result in a higher serum level. Potassium citrate Potassium citrate may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Potassium nitrate Bleomycin may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. Potassium perchlorate Bleomycin may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level. Potassium sulfate Bleomycin may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. Pralatrexate The risk or severity of adverse effects can be increased when Bleomycin is combined with Pralatrexate. Pralidoxime Bleomycin may decrease the excretion rate of Pralidoxime which could result in a higher serum level. Pramipexole Bleomycin may decrease the excretion rate of Pramipexole which could result in a higher serum level. Pramocaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Pramocaine. Prasugrel Bleomycin may decrease the excretion rate of Prasugrel which could result in a higher serum level. Prednisolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Prednisolone. Prednisone The risk or severity of adverse effects can be increased when Bleomycin is combined with Prednisone. Pregabalin Pregabalin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Procarbazine The risk or severity of adverse effects can be increased when Bleomycin is combined with Procarbazine. Promethazine Bleomycin may decrease the excretion rate of Promethazine which could result in a higher serum level. Propantheline Bleomycin may decrease the excretion rate of Propantheline which could result in a higher serum level. Proparacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Proparacaine. Propiverine Bleomycin may decrease the excretion rate of Propiverine which could result in a higher serum level. Propoxycaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Propoxycaine. Propranolol Bleomycin may decrease the excretion rate of Propranolol which could result in a higher serum level. Propylthiouracil The risk or severity of adverse effects can be increased when Bleomycin is combined with Propylthiouracil. Prucalopride Bleomycin may decrease the excretion rate of Prucalopride which could result in a higher serum level. Pyrantel Bleomycin may decrease the excretion rate of Pyrantel which could result in a higher serum level. Pyrazinamide Bleomycin may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Pyrithione Bleomycin may decrease the excretion rate of Pyrithione which could result in a higher serum level. Quetiapine Bleomycin may decrease the excretion rate of Quetiapine which could result in a higher serum level. Quinethazone Quinethazone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Quinidine Bleomycin may decrease the excretion rate of Quinidine which could result in a higher serum level. Rabeprazole Bleomycin may decrease the excretion rate of Rabeprazole which could result in a higher serum level. Rabies immune The therapeutic efficacy of Rabies immune globulin, human can be decreased when used in combination with Bleomycin. Rabies virus The therapeutic efficacy of Rabies virus inactivated antigen, A can be decreased when used in combination with Bleomycin. Rabies virus The therapeutic efficacy of Rabies virus inactivated antigen, B can be decreased when used in combination with Bleomycin. Raltitrexed The risk or severity of adverse effects can be increased when Bleomycin is combined with Raltitrexed. Ramelteon Bleomycin may decrease the excretion rate of Ramelteon which could result in a higher serum level. Ranitidine Bleomycin may decrease the excretion rate of Ranitidine which could result in a higher serum level. Ranolazine Ranolazine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Rasagiline Bleomycin may decrease the excretion rate of Rasagiline which could result in a higher serum level. Ravulizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Ravulizumab. Reserpine Reserpine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Resorcinol Bleomycin may decrease the excretion rate of Resorcinol which could result in a higher serum level. Ribavirin Bleomycin may decrease the excretion rate of Ribavirin which could result in a higher serum level. Ribostamycin Bleomycin may decrease the excretion rate of Ribostamycin which could result in a higher serum level. Rilonacept The risk or severity of adverse effects can be increased when Bleomycin is combined with Rilonacept. Risankizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Risankizumab. Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Bleomycin. Rivaroxaban Bleomycin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. Rizatriptan Bleomycin may decrease the excretion rate of Rizatriptan which could result in a higher serum level. Rofecoxib Rofecoxib may decrease the excretion rate of Bleomycin which could result in a higher serum level. Roflumilast Roflumilast may increase the immunosuppressive activities of Bleomycin. Ropeginterferon The risk or severity of adverse effects can be increased when Bleomycin is combined with Ropeginterferon alfa-2b. Ropivacaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Ropivacaine. Rosiglitazone Bleomycin may decrease the excretion rate of Rosiglitazone which could result in a higher serum level. Rotavirus vaccine The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Bleomycin. Rubella virus vaccine The risk or severity of infection can be increased when Rubella virus vaccine is combined with Bleomycin. Ruxolitinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Ruxolitinib. Sacubitril Bleomycin may decrease the excretion rate of Sacubitril which could result in a higher serum level. Salbutamol Bleomycin may decrease the excretion rate of Salbutamol which could result in a higher serum level. Salicylamide Salicylamide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Salicylic acid Salicylic acid may decrease the excretion rate of Bleomycin which could result in a higher serum level. Salmon calcitonin Salmon calcitonin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Salsalate Salsalate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Sargramostim The risk or severity of adverse effects can be increased when Sargramostim is combined with Bleomycin. Sarilumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Sarilumab. Satralizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Satralizumab. Saxagliptin Bleomycin may decrease the excretion rate of Saxagliptin which could result in a higher serum level. Secobarbital Bleomycin may decrease the excretion rate of Secobarbital which could result in a higher serum level. Secukinumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Secukinumab. Selenious acid Bleomycin may decrease the excretion rate of Selenious acid which could result in a higher serum level. Selenium Bleomycin may decrease the excretion rate of Selenium which could result in a higher serum level. Sibutramine Bleomycin may decrease the excretion rate of Sibutramine which could result in a higher serum level. Siltuximab The risk or severity of adverse effects can be increased when Bleomycin is combined with Siltuximab. Siponimod The risk or severity of adverse effects can be increased when Bleomycin is combined with Siponimod. Sipuleucel-T The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Bleomycin. Sirolimus The risk or severity of adverse effects can be increased when Bleomycin is combined with Sirolimus. Sitagliptin Bleomycin may decrease the excretion rate of Sitagliptin which could result in a higher serum level. Smallpox (Vaccinia) The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Bleomycin. Sodium acetate Bleomycin may decrease the excretion rate of Sodium acetate which could result in a higher serum level. Sodium ascorbate The therapeutic efficacy of Bleomycin can be decreased when used in combination with Sodium ascorbate. Sodium aurothiomalate Bleomycin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium fluoride Bleomycin may decrease the excretion rate of Sodium fluoride which could result in a higher serum level. Sodium sulfate Bleomycin may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Sofosbuvir Bleomycin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. Solriamfetol Bleomycin may decrease the excretion rate of Solriamfetol which could result in a higher serum level. Sorafenib The risk or severity of adverse effects can be increased when Bleomycin is combined with Sorafenib. Sorbitol Bleomycin may decrease the excretion rate of Sorbitol which could result in a higher serum level. Spesolimab The risk or severity of adverse effects can be increased when Bleomycin is combined with Spesolimab. Spironolactone Spironolactone may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Stiripentol Bleomycin may decrease the excretion rate of Stiripentol which could result in a higher serum level. Streptomycin Bleomycin may decrease the excretion rate of Streptomycin which could result in a higher serum level. Streptozocin The risk or severity of adverse effects can be increased when Bleomycin is combined with Streptozocin. Strontium chloride Bleomycin may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Sucralfate Bleomycin may decrease the excretion rate of Sucralfate which could result in a higher serum level. Sulbactam Bleomycin may decrease the excretion rate of Sulbactam which could result in a higher serum level. Sulfadiazine Bleomycin may decrease the excretion rate of Sulfadiazine which could result in a higher serum level. Sulfamethoxazole The risk or severity of myelosuppression can be increased when Sulfamethoxazole is combined with Bleomycin. Sulfasalazine The risk or severity of adverse effects can be increased when Bleomycin is combined with Sulfasalazine. Sulindac Sulindac may decrease the excretion rate of Bleomycin which could result in a higher serum level. Sumatriptan Bleomycin may decrease the excretion rate of Sumatriptan which could result in a higher serum level. Sunitinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Sunitinib. Estrogens, A Bleomycin may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level. Conjugated Estrogens, B Bleomycin may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level. Tacrolimus Tacrolimus may increase the immunosuppressive activities of Bleomycin. Tadalafil Bleomycin may decrease the excretion rate of Tadalafil which could result in a higher serum level. Tamoxifen The risk or severity of cardiotoxicity can be increased when Bleomycin is combined with Tamoxifen. Tamsulosin Bleomycin may decrease the excretion rate of Tamsulosin which could result in a higher serum level. Tasimelteon Bleomycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level. Telavancin Bleomycin may decrease the excretion rate of Telavancin which could result in a higher serum level. Temazepam Temazepam may decrease the excretion rate of Bleomycin which could result in a higher serum level. Temozolomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Temozolomide. Temsirolimus The risk or severity of adverse effects can be increased when Bleomycin is combined with Temsirolimus. Teniposide The risk or severity of adverse effects can be increased when Bleomycin is combined with Teniposide. Tenofovir alafenamide Tenofovir alafenamide may decrease the excretion rate of Bleomycin which could result in a higher serum level. Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Bleomycin which could result in a higher serum level. Tenoxicam Tenoxicam may decrease the excretion rate of Bleomycin which could result in a higher serum level. Teprotumumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Teprotumumab. Terbutaline Bleomycin may decrease the excretion rate of Terbutaline which could result in a higher serum level. Teriflunomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Teriflunomide. Testolactone Bleomycin may decrease the excretion rate of Testolactone which could result in a higher serum level. Testosterone Bleomycin may decrease the excretion rate of Testosterone which could result in a higher serum level. Testosterone cypionate Bleomycin may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level. Testosterone enanthate Bleomycin may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level. Testosterone propionate Bleomycin may decrease the excretion rate of Testosterone propionate which could result in a higher serum level. Testosterone undecanoate Bleomycin may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level. Tetracaine The risk or severity of methemoglobinemia can be increased when Bleomycin is combined with Tetracaine. Tetracycline Bleomycin may decrease the excretion rate of Tetracycline which could result in a higher serum level. Tetradecyl hydrogen Bleomycin may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. Thalidomide The risk or severity of adverse effects can be increased when Bleomycin is combined with Thalidomide. Thiabendazole Bleomycin may decrease the excretion rate of Thiabendazole which could result in a higher serum level. Thiethylperazine Bleomycin may decrease the excretion rate of Thiethylperazine which could result in a higher serum level. Thiotepa The risk or severity of adverse effects can be increased when Bleomycin is combined with Thiotepa. Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Bleomycin which could result in a higher serum level. encephalitis vaccine The therapeutic efficacy of Tick-borne encephalitis vaccine (whole virus, inactivated) can be decreased when used in combination with Bleomycin. Ticlopidine Ticlopidine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Tiludronic acid Bleomycin may decrease the excretion rate of Tiludronic acid which could result in a higher serum level. Timolol Bleomycin may decrease the excretion rate of Timolol which could result in a higher serum level. Tinidazole Bleomycin may decrease the excretion rate of Tinidazole which could result in a higher serum level. Tioguanine The risk or severity of adverse effects can be increased when Bleomycin is combined with Tioguanine. Tiopronin Bleomycin may decrease the excretion rate of Tiopronin which could result in a higher serum level. Tiotropium Bleomycin may decrease the excretion rate of Tiotropium which could result in a higher serum level. Tirofiban Bleomycin may decrease the excretion rate of Tirofiban which could result in a higher serum level. Tixocortol The risk or severity of adverse effects can be increased when Bleomycin is combined with Tixocortol. Tobramycin Bleomycin may decrease the excretion rate of Tobramycin which could result in a higher serum level. Tocilizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Tocilizumab. Tocopherol Bleomycin may decrease the excretion rate of Tocopherol which could result in a higher serum level. Tofacitinib Bleomycin may increase the immunosuppressive activities of Tofacitinib. Tolazamide Bleomycin may decrease the excretion rate of Tolazamide which could result in a higher serum level. Tolbutamide Bleomycin may decrease the excretion rate of Tolbutamide which could result in a higher serum level. Tolcapone Bleomycin may decrease the excretion rate of Tolcapone which could result in a higher serum level. Tolfenamic acid Tolfenamic acid may decrease the excretion rate of Bleomycin which could result in a higher serum level. Tolmetin Tolmetin may decrease the excretion rate of Bleomycin which could result in a higher serum level. Tolterodine Bleomycin may decrease the excretion rate of Tolterodine which could result in a higher serum level. Tolvaptan Tolvaptan may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Topiramate Topiramate may decrease the excretion rate of Bleomycin which could result in a higher serum level. Topotecan The risk or severity of adverse effects can be increased when Bleomycin is combined with Topotecan. Torasemide Torasemide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Bleomycin. Trabectedin The risk or severity of adverse effects can be increased when Bleomycin is combined with Trabectedin. Tramadol Tramadol may decrease the excretion rate of Bleomycin which could result in a higher serum level. Trametinib Bleomycin may decrease the excretion rate of Trametinib which could result in a higher serum level. Trastuzumab Trastuzumab may increase the neutropenic activities of Bleomycin. Trastuzumab emtansine The risk or severity of adverse effects can be increased when Bleomycin is combined with Trastuzumab emtansine. Tretinoin The risk or severity of adverse effects can be increased when Bleomycin is combined with Tretinoin. Triamcinolone The risk or severity of adverse effects can be increased when Bleomycin is combined with Triamcinolone. Triamterene Triamterene may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Triazolam Bleomycin may decrease the excretion rate of Triazolam which could result in a higher serum level. Trichlormethiazide Trichlormethiazide may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy. Triethylenetetramine Bleomycin may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level. Trifluridine The risk or severity of adverse effects can be increased when Bleomycin is combined with Trifluridine. Trilostane The risk or severity of adverse effects can be increased when Bleomycin is combined with Trilostane. Trimebutine Bleomycin may decrease the excretion rate of Trimebutine which could result in a higher serum level. Trimethoprim Bleomycin may decrease the excretion rate of Trimethoprim which could result in a higher serum level. Trimetrexate Bleomycin may decrease the excretion rate of Trimetrexate which could result in a higher serum level. Tropisetron Bleomycin may decrease the excretion rate of Tropisetron which could result in a higher serum level. Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Bleomycin. Typhoid Vaccine Live The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Bleomycin. polysaccharide vaccine The therapeutic efficacy of Typhoid Vi polysaccharide vaccine can be decreased when used in combination with Bleomycin. Upadacitinib The risk or severity of adverse effects can be increased when Bleomycin is combined with Upadacitinib. Vaborbactam Bleomycin may decrease the excretion rate of Vaborbactam which could result in a higher serum level. Valaciclovir Valaciclovir may decrease the excretion rate of Bleomycin which could result in a higher serum level. Valbenazine Bleomycin may decrease the excretion rate of Valbenazine which could result in a higher serum level. Valdecoxib Valdecoxib may decrease the excretion rate of Bleomycin which could result in a higher serum level. Valganciclovir Bleomycin may decrease the excretion rate of Valganciclovir which could result in a higher serum level. Valproic acid The serum concentration of Valproic acid can be decreased when it is combined with Bleomycin. Vancomycin Bleomycin may decrease the excretion rate of Vancomycin which could result in a higher serum level. Varenicline Bleomycin may decrease the excretion rate of Varenicline which could result in a higher serum level. Varicella zoster The risk or severity of infection can be increased when Varicella zoster vaccine (live/attenuated) is combined with Bleomycin. Varicella zoster The therapeutic efficacy of Varicella zoster vaccine (recombinant) can be decreased when used in combination with Bleomycin. Vedolizumab The risk or severity of adverse effects can be increased when Bleomycin is combined with Vedolizumab. Venlafaxine Venlafaxine may decrease the excretion rate of Bleomycin which could result in a higher serum level. Verapamil Bleomycin may decrease the excretion rate of Verapamil which could result in a higher serum level. Vibrio cholerae The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Bleomycin. Vilanterol The risk or severity of adverse effects can be increased when Bleomycin is combined with Vilanterol. Viloxazine Bleomycin may decrease the excretion rate of Viloxazine which could result in a higher serum level. Vinblastine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vinblastine. Vincristine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vincristine. Vindesine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vindesine. Vinorelbine The risk or severity of adverse effects can be increased when Bleomycin is combined with Vinorelbine. Voclosporin The risk or severity of adverse effects can be increased when Bleomycin is combined with Voclosporin. Vorinostat The risk or severity of adverse effects can be increased when Bleomycin is combined with Vorinostat. Vortioxetine Bleomycin may decrease the excretion rate of Vortioxetine which could result in a higher serum level. Warfarin Bleomycin may decrease the excretion rate of Warfarin which could result in a higher serum level. Pregnancy and Lactation FDA Pregnancy Category D  Pregnancy Studies of this medication have not been done with pregnant women. There is a possibility of birth defects if either the father or mother is using bleomycin at the time of conception, or if it is taken during pregnancy. Effective birth control should be practiced while using this medication. Tell the doctor immediately if you become pregnant while using this medication. Lactation Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence. Although no data are available to determine an appropriate period to withhold breastfeeding, the drug's terminal half-life of 4 hours with normal kidney function suggests that withholding breastfeeding for at least 24 hours may be sufficient. This period may be longer in patients with impaired kidney function. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breast milk. Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant. How should this medicine be used?

Bleomycin comes as a powder to be mixed with liquid and injected intravenously (into a vein), intramuscularly (into a muscle), or subcutaneously (under the skin) by a doctor or nurse in a medical office or hospital outpatient department. It is usually injected once or twice a week. When bleomycin is used to treat pleural effusions, it is mixed with liquid and placed in the chest cavity through a chest tube (plastic tube that is placed in the chest cavity through…

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