Disease A-Z Library

Degenerative Bones, Joints, and Spine Care (A – Z)

Browse plain-English disease and condition guides, including symptoms, causes, diagnosis, treatment options, prevention, and when to seek medical care.

3,214 articlesUpdated medical education library

Diseases A-Z

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Disease A-Z Library

Jarcho-Levin Syndrome

Jarcho-Levin syndrome is a genetic (inherited) condition that starts in early embryo life. The “body clock” that times the making of spinal segments does not work...

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Disease A-Z Library

Osteoclast-Poor Osteopetrosis

Osteoclast-poor osteopetrosis is a very rare, inherited bone disease. In this condition, the body cannot make enough working osteoclasts. Osteoclasts are the bone cells that remove...

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Hypophosphatemic Rickets

Hypophosphatemic rickets is a bone disease where the body loses too much phosphate in the urine. Phosphate is a mineral your bones need to harden and...

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Geroderma Osteodysplasticum (GO)

Geroderma osteodysplasticum (GO) is a rare, inherited condition that makes the skin loose and wrinkled and the bones fragile. Children are usually born looking small or...

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Cutis Laxa with Bone Dystrophy

Cutis laxa with bone dystrophy is a rare connective-tissue disorder in which the skin is loose, saggy, and less elastic because elastic fibers and related matrix proteins are...

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Osteosclerosis Fragilis

Osteosclerosis fragilis is an old, Latinized name that physicians used for a condition in which bones look very dense (sclerotic) but are paradoxically fragile. Today, this...

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Spondylolysis

Spondylolysis means there is a small break (a “stress fracture”) or a thinning/defect in a narrow bridge of bone at the back of a vertebra called...

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Aneurysm Osteoarthritis Syndrome (AOS)

Aneurysm-osteoarthritis syndrome is a rare, inherited connective-tissue disorder. It mainly causes bulging (aneurysms), stretching (tortuosity), or tearing (dissection) of arteries anywhere in the body, and it...

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Dysostosis

Dysostosis is a group of birth conditions that affect how certain bones form and join. The problem starts very early in pregnancy when the baby’s skeleton...

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Sesamoiditis

Sesamoiditis is an overuse injury characterized by inflammation of the two tiny sesamoid bones embedded under the big toe joint (the first metatarsophalangeal joint). These sesame‑seed–shaped...

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Infectious (Septic) Dactylitis

Infectious (Septic) Dactylitis is a specific form of dactylitis in which an invading pathogen—most often bacteria—infects the bone (osteomyelitis) and surrounding soft-tissue sheath (tenosynovitis) of an...

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