Autoimmune Diseases; Types, Symptoms, Treatment

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Autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases.[rx] Nearly any body part can be involved.[rx] Common symptoms include low-grade fever and feeling tired.[rx] Often symptoms come and go.[rx]

Types of Autoimmune Diseases

Acquired pure red cell aplasia

Synonyms: Idiopathic pure red cell aplasia, Adult pure red cell aplasia, Acquired PRCA
Addison’s disease

Synonyms: Addison disease, Adrenal hypoplasia, Hypoadrenocorticism familial, Adrenal aplasia, Adrenal gland hypofunction
Alopecia areata

Synonyms: AA, Diffuse alopecia, Patchy alopecia, Marginal alopecia, Alopecia Celsi, Alopecia Cicatrisata, Alopecia Circumscripta, Cazenave’s Vitiligo, Celsus’ Vitiligo, Jonston’s Alopecia
Alopecia universalis

Synonyms: Alopecia areata universalis, AU
Ankylosing spondylitis

Synonyms: Ankylosing spondyloarthritis, Bechterew syndrome, Marie-Strumpell spondylitis
Annular atrophic lichen planus

Synonyms: Annular atrophic LP
Annular lichen planus

Synonyms: Annular LP
Antiphospholipid syndrome

Synonyms: Familial antiphospholipid syndrome, Antiphospholipid antibody syndrome, Lupus anticoagulant, familial, APS, Hughes syndrome
Antisynthetase syndrome

Synonyms: Anti-Jo1 syndrome, AS syndrome
Artritis idiopática juvenil

Synonyms: Artritis juvenil crónica, Artritis juvenil reumatoide, Artritis reumatoide juvenil
Atrophic lichen planus

Synonyms: Atrophic LP
Autoimmune autonomic ganglionopathy

Synonyms: Autoimmune Autonomic Neuropathy
Autoimmune hemolytic anemia

Synonyms: Anemia hemolytic autoimmune, Acquired autoimmune hemolytic anemia, Idiopathic autoimmune hemolytic anemia, Familial auto-immune hemolytic anemia (subtype), Immuno-hemolytic anemia
Autoimmune hepatitis

Synonyms: Autoimmune chronic hepatitis, AIH
Autoimmune lymphoproliferative syndrome

Synonyms: ALPS, Canale-Smith syndrome, Autoimmune lymphoproliferative syndrome type 1, autosomal dominant, FAS deficiency
Autoimmune pancreatitis

Synonyms: Lymphoplasmocytic sclerosing pancreatitis
Autoimmune polyglandular syndrome type 1

Synonyms: APS 1, Autoimmune polyendocrine syndrome type 1, Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), Hypoadrenocorticism with hypoparathyroidism and superficial moniliasis, Autoimmune polyendocrinopathy syndrome type 1, Polyglandular autoimmune syndrome type 1, PGA 1, PGA-I, Whitaker syndrome, Type I Polyglandular Autoimmune Syndrome, Autoimmune polyglandular syndrome type I
Autoimmune polyglandular syndrome type 2

Synonyms: Diabetes mellitus, Addison’s disease, myxedema, Multiple endocrine deficiency syndrome, type 2, Polyglandular autoimmune syndrome, type 2, Autoimmune polyendocrine syndrome type 2, Schmidt syndrome, Schmidt’s syndrome, APS2, PGA 2, Polyglandular deficiency syndrome type 2, Autoimmune polyglandular syndrome type II, PGA-II
Autoimmune polyglandular syndrome type 3

Synonyms: Autoimmune polyendocrine syndrome type 3, APS3, Polyglandular autoimmune syndrome type 3, PAS3, Autoimmune polyglandular syndrome type III, PGA-III
Behçet disease

Synonyms: Behçet’s syndrome, Behçet syndrome, BD, Behcet syndrome, Behcet’s disease, Behçet’s disease, Behcet’s syndrome, Behçet’s disease
Blau syndrome

Synonyms: Arthrocutaneouveal granulomatosis, ACUG, Granulomatosis, familial, Blau type, Granulomatous inflammatory arthritis, dermatitis, and uveitis, familial, Synovitis granulomatous with uveitis and cranial neuropathies, Granulomatosis, familial juvenile systemic, Jabs syndrome
Bullous pemphigoid

Synonyms: Senile Dermatitis Herpetiformis, Pemphigoid, Parapemphigus, Old Age Pemphigus, Benign Pemphigus
Castleman disease

Synonyms: Angiofollicular ganglionic hyperplasia, Angiofollicular lymph hyperplasia, Giant lymph node hyperplasia, Benign giant lymphoma
Catastrophic antiphospholipid syndrome

Synonyms: Catastrophic antiphospholipid antibody syndrome, Thrombotic storm
Chronic inflammatory demyelinating polyneuropathy

Synonyms: CIDP, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Chronic recurrent multifocal osteomyelitis

Synonyms: CRMO, Multifocal osteomyelitis, chronic, Chronic multifocal osteomyelitis, CMO, Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis, CNO/CRMO
Cicatricial pemphigoid

Synonyms: Benign mucosal pemphigoid, Benign mucous membrane pemphigoid
Cogan’s syndrome

Synonyms: Cogan syndrome
Cold agglutinin disease

Synonyms: Anemia, hemolytic, cold antibody, Cold antibody hemolytic anemia, Cold antibody disease, CAD
Complement component 2 deficiency

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Congenital heart block

Synonyms: Heart block congenital
Cutaneous lupus erythematosus

Synonyms: Lupus erythematosus, cutaneous
Demyelinating disease of central nervous system

Synonyms: Demyelinating CNS disease
Dermatitis herpetiformis familial

Synonyms: Dermatitis herpetiformis, Duhring-Brocq disease

Synonyms: Adult dermatomyositis
Eosinophilic enteropathy

Synonyms: Eosinophilic gastroenteritis, Eosinophilic gastritis, Eosinophilic enteritis, Eosinophilic gastroenteropathy, Eosinophilic esophagitis
Eosinophilic fasciitis

Synonyms: Shulman syndrome, EF
Eosinophilic granulomatosis with polyangiitis

Synonyms: CSS, Allergic granulomatous and angiitis, Allergic angiitis and granulomatosis, Allergic granulomatosis, Churg-Strauss vasculitis, Granulomatous allergic angiitis, Churg-Strauss syndrome, EGPA
Epidermolysis bullosa acquisita

Synonyms: EB acquisita, EBA, Acquired epidermolysis bullosa
Erythema nodosum, idiopathic

Synonyms: Idiopathic erythema nodosum, Erythema nodosum of unknown etiology
Evans syndrome

Synonyms: Autoimmune hemolytic anemia and autoimmune thrombocytopenia, Evan syndrome
Familial cold autoinflammatory syndrome

Synonyms: FCAS, Familial polymorphous cold eruption, Familial cold urticaria
Familial erythema nodosum

Synonyms: Erythema nodosum, familial
Febrile Ulceronecrotic Mucha-Habermann disease

Synonyms: FUMHD, Ulceronecrotic Mucha-Habermann disease, Variant of Mucha-Habermann disease
Felty’s syndrome

Synonyms: Felty syndrome, Rheumatoid arthritis, splenomegaly and neutropenia, Familial Felty’s syndrome
Fibrosis retroperitoneal

Synonyms: Enfermedad de Ormond
Giant cell arteritis

Synonyms: GCA, Temporal arteritis, Cranial arteritis, Horton’s disease, Horton’s arteritis, Horton’s giant cell arteritis, Horton’s syndrome, Horton’s temporal arteritis, Arteritis temporalis, Arteritis cranialis
Giant cell myocarditis

Synonyms: GCM, Idiopathic giant-cell myocarditis

Synonyms: Bright’s disease
Goodpasture syndrome

Synonyms: Rapidly progressive glomerulonephritis with pulmonary hemorrhage, Anti-glomerular basement membrane antibody disease, Glomerulonephritis – pulmonary hemorrhage, Pulmonary renal syndrome
Granulomatosis with polyangiitis

Synonyms: GPA, WG, Wegener granulomatosis, Midline granulomatosis
Graves disease

Synonyms: Basedow disease, Exophthalmic goiter, Parry disease, Graves’ hyperthyroidism
Guillain-Barre syndrome

Synonyms: Acute autoimmune peripheral neuropathy, GBS, Acute immune-mediated polyneuropathy, Acute inflammatory demyelinating polyneuropathy, Acute inflammatory demyelinating polyradiculoneuropathy, Acute inflammatory neuropathy, Acute inflammatory polyneuropathy, Landry-Guillain-Barre-Strohl syndrome, Landry’s ascending paralysis, Post-infective polyneuritis, Guillain-Barré syndrome, Guillain-Barré-Strohl syndrome
Hashimoto encephalopathy

Synonyms: Hashimoto’s encephalopathy, Steroid-responsive encephalopathy associated with autoimmune thyroiditis
Hashimoto’s syndrome

Synonyms: Autoimmune thyroiditis, Hashimoto’s disease, Thyroiditis, chronic, Hashimoto’s struma, Chronic lymphocytic thyroiditis, Hashimoto’s thyroiditis
Henoch-Schonlein purpura

Synonyms: Purpura, Schonlein-Henoch, Anaphylactoid purpura, Vascular purpura, Henoch Schonlein purpura, Immunoglobulin A vasculitis, Immunoglobulin-A vasculitis
Hyper IgE syndrome

Synonyms: Hyperimmunoglobulin E syndrome, HIES, Hyper-IgE recurrent infection syndrome
Idiopathic pulmonary fibrosis

Synonyms: Fibrosing alveolitis, cryptogenic, Familial idiopathic pulmonary fibrosis, Fibrocystic pulmonary dysplasia, Fibrosing alveolitis
Idiopathic thrombocytopenic purpura

Synonyms: ITP, Autoimmune thrombocytopenic purpura, Thrombocytopenic purpura autoimmune
IgA nephropathy

Synonyms: Nephritis, IGA type, IGAN, Glomerulonephritis, IGA, Berger’s disease, Berger disease
IgG4-related dacryoadenitis and sialadenitis

Synonyms: Mikulicz’s disease (former), Mikulicz disease (former), Mikulicz syndrome (former), Chronic dacryoadenitis and sialadenitis
Inclusion body myositis

Synonyms: IBM, Inflammatory myopathy, Sporadic inclusion body myositis
Insulin autoimmune syndrome

Synonyms: Hirata disease, Insulin autoimmune hypoglycemia
Interstitial cystitis

Synonyms: IC, Pelvic pain syndrome, Trigonitis, Painful bladder syndrome, PBS, Bladder pain syndrome, IC/BPS, IC/PBS, Interstitial cystitis/bladder pain syndrome, Interstitial cystitis/painful bladder syndrome
Juvenile dermatomyositis

Synonyms: JDM, Juvenile myositis, JPM
Juvenile idiopathic arthritis

Synonyms: Juvenile rheumatoid arthritis, Arthritis, juvenile rheumatoid, Juvenile chronic arthritis, Juvenile arthritis
Kawasaki disease

Synonyms: Mucocutaneous lymph node syndrome, Kawasaki syndrome
Lambert Eaton myasthenic syndrome

Synonyms: LEMS, Eaton Lambert syndrome, Lambert Eaton syndrome, Myasthenic syndrome of Lambert-Eaton, Myasthenic-Myopathic syndrome of Lambert-Eaton
Lichen planopilaris

Synonyms: Follicular lichen planus, Frontal fibrosing alopecia (subtype), Kossard disease, Lichen planopilaris classic type, LPP, Lichen planus follicularis, Lichen follicularis
Lichen planus pemphigoides

Synonyms: LP pemphigoides
Lichen sclerosus

Synonyms: Lichen sclerosis, Lichen sclerosis et atrophicus, Lichen sclerosus et atrophicus
Limited cutaneous systemic sclerosis

Synonyms: Limited cutaneous systemic scleroderma
Linear IgA disease

Synonyms: Linear IgA dermatosis, Linear immunoglobulin A (IgA) dermatosis, LAD, Linear IgA bullous dermatosis
Linear lichen planus

Synonyms: Blaschkoid LP, Blaschkoid lichen planus, Linear LP, LLP

Synonyms: Systemic lupus erythematosus, Disseminated lupus erythematosus, Lupus erythematosus, Discoid lupus, Subacute cutaneous lupus, SLE
Mannose-binding lectin protein deficiency

Synonyms: MBL deficiency, Mannose-binding protein deficiency
Ménière’s disease

Synonyms: Meniere’s disease, Meniere disease
Microscopic polyangiitis

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Mixed connective tissue disease

Synonyms: MCTD, Sharp syndrome
Multiple sclerosis

Synonyms: MS
Myasthenia gravis congenital

Synonyms: Congenital MG, Myasthenia gravis pseudoparalytica, Erb-Goldflam syndrome

Synonyms: Narcoleptic syndrome, Gelineau syndrome, Gelineau’s syndrome, Narcolepsy-cataplexy syndrome, Paroxysmal sleep
Neonatal systemic lupus erythematosus

Synonyms: Neonatal SLE, Neonatal lupus syndrome, Neonatal lupus, Congenital lupus erythematosus, Congenital lupus
Neuromyelitis optica

Synonyms: Devic syndrome, NMO, Devic’s neuromyelitis optica, Devic disease, NMO spectrum disorder
Ocular cicatricial pemphigoid

Synonyms: Cicatricial pemphigoid, ocular, Pemphigoid, ocular cicatricial
Palindromic rheumatism

Synonyms: Palindromic rheumatism syndrome, Hench-Rosenberg syndrome, Hench’s syndrome
Paroxysmal nocturnal hemoglobinuria

Synonyms: PNH, Marchiafava-Micheli disease
Pars planitis

Synonyms: Intermediate uveitis, Peripheral retinal inflammation, Vitritis
Parsonage Turner syndrome

Synonyms: Acute brachial neuritis, Acute brachial neuritis syndrome, Acute brachial radiculitis syndrome, Acute shoulder neuritis, Idiopathic neuralgic amyotrophy
Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections

Synonyms: PANDAS, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, Pediatric autoimmune disorders associated with Streptococcus infections
Pernicious anemia

Synonyms: Acquired pernicious anemia, Biermer anemia, Addison-Biermer anemia, Addisonian anemia, Juvenile onset pernicious anemia, Biermer’s disease
POEMS syndrome

Synonyms: Polyneuropathy organomegaly, Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin changes syndrome, Crow-Fukase syndrome
Polyarteritis nodosa

Synonyms: PAN, Periarteritis, Polyarteritis
Primary agammaglobulinemia

Synonyms: Antibody Deficiency, Gammaglobulin Deficiency, Immunoglobulin Deficiency
Primary biliary cholangitis

Synonyms: PBC, Familial primary biliary cirrhosis, Primary Biliary Cirrhosis
Primary sclerosing cholangitis

Synonyms: Cholangitis, primary sclerosing, Sclerosing cholangitis
Progressive hemifacial atrophy

Synonyms: Parry-Romberg syndrome, Hemifacial atrophy, progressive, Romberg hemi-facial atrophy
Psoriatic juvenile idiopathic arthritis

Synonyms: Juvenile psoriatic arthritis, Psoriasis-related JIA, Psoriasis-related juvenile idiopathic arthritis
Pure red cell aplasia

Synonyms: PRCA
Rare lichen planus

Synonyms: Rare LP
Reactive arthritis

Synonyms: Post-infectious arthritis, Post-infectious reactive arthropathy, PIRA, Reiter syndrome, Reiter’s syndrome
Relapsing polychondritis

Synonyms: Chronic atrophic polychondritis, Recurrent polychondritis, Polychondropathia
Restless legs syndrome, susceptibility to, 6

Synonyms: RLS6, Periodic limb movements in sleep
Retroperitoneal fibrosis

Synonyms: Idiopathic retroperitoneal fibrosis, Ormond’s disease, IgG4-related retroperitoneal fibrosis, Ormond disease
Rheumatic Fever

Synonyms: Acute Rheumatic Fever, Inflammatory Rheumatism

Synonyms: Sarcoid of Boeck, Schaumann’s disease

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Selective IgA deficiency

Synonyms: IGAD1, Immunoglobulin A, selective deficiency of, IgA, selective deficiency of, Gamma-A-globulin, selective deficiency of, Immunoglobulin A deficiency 1
Síndrome de Guillain-Barré

Synonyms: Síndrome de Guillain-Barré-Strohl
Sjogren syndrome

Synonyms: Sicca syndrome, Sjogren-Gougerot syndrome
Stiff person syndrome

Synonyms: Stiff man syndrome, Morsch Woltman syndrome, SPS, Moersch-Woltman syndrome, SMS, Stiff person syndrome and related disorders
Subacute cerebellar degeneration

Synonyms: Cerebellar degeneration, subacute, SCD, Alcoholic cerebellar degeneration, Nutritional cerebellar degeneration
Susac syndrome

Synonyms: Retinocochleocerebral vasculopathy, SICRET (small infarction of cochlear, retinal, and encephalic tissue) syndrome
Takayasu arteritis

Synonyms: TA, Young female arteritis, Takayasu disease, Pulseless disease, Aortic arch syndrome
Tolosa Hunt syndrome

Synonyms: THS, Painful ophthalmoplegia, Nonspecific inflammation of the cavernous sinus or superior orbital fissure, Tolosa-Hunt syndrome
Undifferentiated connective tissue disease 

Synonyms: Undifferentiated connective tissue syndrome, UCTD
Unicentric Castleman disease

Synonyms: Unicentric angiofollicular ganglionic hyperplasia, Unicentric angiofollicular lymph hyperplasia, Localized Castleman disease

Synonyms: Vasculitis, autoimmune, Angiitis, Autoimmune vasculitis
Vogt-Koyanagi-Harada disease

Synonyms: VKH syndrome, Vogt-Koyanagi-Harada syndrome, Uveomenigitic syndrome, VKH disease
Warm antibody hemolytic anemia

Synonyms: Warm-reacting-antibody hemolytic anemia, Warm antibody autoimmune hemolytic anemia, Warm antibody AIHA
Wells syndrome

Synonyms: Eosinophilic cellulitis, Bullous cellulitis with eosinophilia, Wells’ syndrome

Symptoms of Autoimmune Diseases

Autoimmune diseases have a wide variety of different effects. They do tend to have one of three characteristic pathological effects which characterize them as autoimmune diseases:[rx]

  1. Damage to or destruction of tissues
  2. Altered organ growth
  3. Altered organ function

It has been estimated that autoimmune diseases are among the leading causes of death among women in the United States in all age groups up to 65 years.[rx] A substantial minority of the population suffers from these diseases, which are often chronic, debilitating, and life-threatening. There are more than 80 illnesses caused by autoimmunity.[rx]

Causes of Autoimmune Diseases

The cause is generally unknown.[rx] Some autoimmune diseases such as lupus run in families, and certain cases may be triggered by infections or other environmental factors.[rx] There are more than 100 autoimmune diseases.[rx]Some common diseases that are generally considered autoimmune include celiac disease, diabetes mellitus type 1, Graves’ disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.[rx][rx]


Autoimmune diseases

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