Conjunctival lymphoma is a malignant tumor arising from the lymphoid tissue located in the conjunctiva, the thin membrane covering the white part of the eye and the inner eyelids. It represents a form of ocular adnexal lymphoma, most commonly derived from B‑lymphocytes that inhabit mucosa‑associated lymphoid tissue (MALT) of the conjunctiva. Patients often present with a slow‑growing, painless, salmon‑pink patch on the eye surface, reflecting the fleshy infiltrate of neoplastic lymphocytes beneath the conjunctival epithelium PMCPubMed.
Epidemiologically, approximately 5–15% of all extranodal lymphomas involve the ocular adnexa, and among these, about 25% occur in the conjunctiva. Nearly 98% of conjunctival lymphomas originate from B cells, with the remaining cases comprising rare T‑cell or natural killer cell variants PubMed. The average age at diagnosis is in the sixth decade of life, though cases span a broad age range. Because early signs are often subtle, diagnosis may be delayed by several months.
Pathophysiologically, chronic antigenic stimulation of conjunctival MALT can trigger clonal expansion of B cells. Genetic abnormalities—such as translocations involving the MALT1 gene—contribute to malignant transformation. Subtypes of the disease differ in aggressiveness and molecular profile, but all share the hallmark of uncontrolled lymphocyte proliferation in the conjunctival stroma Nature.
Types
Extranodal Marginal Zone B‑Cell Lymphoma (MALT Lymphoma):
This is the most frequent subtype, accounting for roughly 80% of conjunctival lymphomas. It arises from marginal zone B cells within conjunctival MALT and typically follows an indolent course. Characteristic histology shows small‑to‑medium lymphocytes with monocytoid appearance, often expressing CD20 and BCL2 but lacking CD10 and cyclin D1 PubMed.
Follicular Lymphoma:
Representing about 8% of cases, follicular lymphoma in the conjunctiva features neoplastic germinal center B cells forming follicle‑like structures. It tends to be low‑grade but may recur locally if not completely excised. Immunophenotyping shows CD10 and BCL6 positivity, with a characteristic t(14;18) translocation in many cases PubMed.
Diffuse Large B‑Cell Lymphoma (DLBCL):
A more aggressive subtype comprising roughly 3% of conjunctival lymphomas. These tumors consist of large transformed B cells with brisk mitotic activity and a tendency for rapid growth. DLBCL requires prompt systemic evaluation and aggressive therapy, often including combination immunochemotherapy PubMed.
Mantle Cell Lymphoma:
Also about 3% of conjunctival cases, mantle cell lymphoma arises from naïve mantle zone B cells and carries a cyclin D1 (CCND1) overexpression due to t(11;14). It has an intermediate to aggressive behavior and often necessitates systemic treatment rather than local therapies PubMed.
Causes and Risk Factors
1. Advanced Age:
The likelihood of conjunctival lymphoma increases with age, particularly in adults over 60 years. Age‑related decline in immune surveillance may permit neoplastic B‑cell clones to expand unchecked Verywell Health.
2. Male Sex:
Some studies report a slight male predominance in ocular adnexal lymphomas, suggesting hormonal or genetic influences on risk Verywell Health.
3. Immune Deficiency:
Conditions that impair immune function, such as HIV/AIDS or congenital immunodeficiencies, reduce tumor immunosurveillance and predispose to lymphoproliferative disorders, including conjunctival lymphoma Nature.
4. Autoimmune Diseases (e.g., Sjögren’s Syndrome):
Chronic autoimmune inflammation in disorders like Sjögren’s syndrome and Hashimoto’s thyroiditis promotes persistent antigenic stimulation of conjunctival MALT, increasing the risk of malignant transformation Nature.
5. IgG4‑Related Disease:
An immune‑mediated fibroinflammatory condition characterized by tissue infiltration with IgG4‑positive plasma cells. It has been implicated in the pathogenesis of certain MALT lymphomas, including those of the conjunctiva Nature.
6. Genetic Mutations:
Chromosomal aberrations—such as t(11;18)(q21;q21) involving the MALT1 gene, trisomy 3, and deletions in 6q—are frequently found in conjunctival MALT lymphomas, driving uncontrolled B‑cell proliferation Nature.
7. Chronic Conjunctival Inflammation:
Long‑standing inflammatory conditions of the conjunctiva (e.g., phlyctenular keratoconjunctivitis) can create a microenvironment conducive to lymphoid hyperplasia and eventual neoplastic change Nature.
8. Infectious Agents – Chlamydia psittaci:
An intracellular bacterium linked to conjunctival MALT lymphoma in some regions. It may drive lymphomagenesis through chronic antigenic stimulation and genetic instability Nature.
9. Infectious Agents – Helicobacter pylori:
Although best known for gastric MALT lymphoma, H. pylori has been detected in some ocular adnexal lymphomas, suggesting a possible but inconsistent role in conjunctival cases Nature.
10. Infectious Agents – Hepatitis C Virus:
HCV infection has been associated with MALT lymphomas at various extranodal sites, including the ocular adnexa, possibly via chronic immune activation Nature.
11. Immunosuppressive Medications:
Therapies such as systemic corticosteroids or biologic agents that dampen immune responses may inadvertently reduce antitumor surveillance, increasing lymphoma risk Nature.
12. Organ Transplantation:
Solid organ transplant recipients require lifelong immunosuppression, which is strongly linked to post‑transplant lymphoproliferative disorders, including ocular adnexal lymphomas Verywell Health.
13. Radiation Exposure:
Therapeutic radiation to the head or neck region can induce DNA damage in conjunctival cells, potentially leading to malignant transformation years later Verywell Health.
14. Environmental Exposures (e.g., Benzene, Pesticides):
Occupational or environmental contact with solvents, benzene, and agricultural chemicals has been implicated in non‑Hodgkin lymphomas and may similarly affect conjunctival MALT Verywell Health.
15. Obesity:
Adiposity‑related chronic inflammation and altered immune regulation contribute to elevated lymphoma risk, including extranodal presentations such as conjunctival lymphoma Verywell Health.
Symptoms
Painless Salmon‑Pink Patch:
The most common presentation is a slowly enlarging, non‑tender, salmon‑pink conjunctival lesion, often best seen at the fornices WebEye.
Foreign Body Sensation:
Patients frequently report a scratching or gritty feeling, caused by the rough surface of the infiltrated conjunctiva rubbing against the cornea WebEye.
Ocular Irritation and Redness:
Local inflammation can produce mild irritation and conjunctival hyperemia, especially in low‑grade lymphomas with subtle vascular proliferation EyeWiki.
Tearing (Epiphora):
Tumor‑induced irritation or mechanical obstruction of the punctum may lead to increased tear production and overflow EyeWiki.
Dryness:
Altered tear film dynamics from chronic irritation can cause dryness and discomfort EyeWiki.
Ptosis:
When lymphomatous infiltrate involves the upper conjunctiva near the tarsal plate, it may drag down the eyelid, causing drooping EyeWiki.
Chemosis:
Localized conjunctival swelling can occur, giving a “boggy” appearance over the lesion Nature.
Hyperemia:
Prominent capillaries within the lymphoid mass may impart a deeper red hue to the lesion area Nature.
Discharge:
Mild mucoid discharge may accompany irritation, though frank purulence is rare Nature.
Diplopia:
Less commonly, large or orbital‑extending lesions can restrict extraocular muscle movement, resulting in double vision PMC.
Diagnostic Tests
Physical Examination Tests
1. Visual Acuity Test:
Measures the clarity of vision using standardized eye charts. While not diagnostic of lymphoma itself, reduced acuity can signal corneal involvement or secondary effects on the ocular surface WebEye.
2. Pupillary Light Reflex:
Assesses optic nerve and retinal function; normal in most conjunctival lymphomas but important to rule out broader ocular or neurological pathology WebEye.
3. Intraocular Pressure Measurement (Tonometry):
Evaluates for secondary glaucoma from tumor‑induced inflammation or angle involvement; typically normal in isolated conjunctival lymphoma American Academy of Ophthalmology.
Manual Tests
4. Eyelid Eversion and Fornix Inspection:
Manual eversion of the eyelid reveals hidden lesions in the fornices, where lymphomas often originate WebEye.
5. Palpation of Periocular Mass:
Gentle digital palpation over the orbital rims and eyelids helps assess tumor consistency and mobility WebEye.
6. Regional Lymph Node Palpation:
Examination of preauricular and submandibular nodes identifies possible regional spread WebEye.
Laboratory and Pathological Tests
7. Conjunctival Biopsy and Histopathology:
A definitive diagnostic test wherein tissue is examined microscopically to identify malignant lymphoid cells PMC.
8. Immunohistochemistry (IHC):
Uses antibodies against markers such as CD20, CD3, CD5, and BCL2 to subtype lymphoma and guide therapy Lymphoma Research Foundation.
9. Flow Cytometry:
Analyzes cell surface antigens on fresh tissue to confirm clonality and B‑cell involvement PMC.
10. Polymerase Chain Reaction (PCR) for IgH Gene Rearrangement:
Detects clonal immunoglobulin heavy chain rearrangements, distinguishing lymphoma from reactive hyperplasia PMC.
11. Complete Blood Count (CBC) with Differential:
Helps rule out systemic involvement and assesses bone marrow function; though not diagnostic, it aids staging Cancer.org.
12. Lactate Dehydrogenase (LDH) Level:
An indirect marker of tumor burden; elevated levels correlate with higher-grade disease and poorer prognosis Cancer.org.
Electrodiagnostic Tests
13. Visual Evoked Potentials (VEP):
Measures electrical responses of the visual cortex to patterned stimuli, useful if optic pathway involvement is suspected NCBI.
14. Full‑Field Electroretinography (ffERG):
Assesses global retinal function by recording electrical responses to light flashes; typically normal in conjunctival lymphoma but valuable to exclude retinal diseases NCBI.
15. Electrooculography (EOG):
Evaluates retinal pigment epithelium function through corneo‑retinal standing potentials; rarely abnormal in conjunctival lymphoma but part of comprehensive ocular electrophysiology Wikipedia.
Imaging Tests
16. B‑Scan Ultrasonography:
High‑resolution ultrasound visualizes subepithelial masses and measures their depth and extent; a non‑invasive, rapid bedside tool PMC.
17. Ultrasound Biomicroscopy (UBM):
Uses high‑frequency ultrasound for detailed imaging of anterior segment structures, helping assess lesion infiltration into the fornix and sclera journal.opted.org.
18. Orbital Computed Tomography (CT) Scan:
Provides cross‑sectional images of the orbit, delineating mass density, bony remodeling, and involvement of adjacent orbital fat Radiopaedia.
19. Magnetic Resonance Imaging (MRI):
Offers superior soft tissue contrast to evaluate lesion extent, orbital extension, and possible intracranial involvement PMC.
20. Positron Emission Tomography–CT (PET‑CT):
Used in staging to detect systemic disease by highlighting areas of increased metabolic activity; sensitivities of 85% for PET and 70% for CT in ocular adnexal lymphoma EyeWiki.
Non-Pharmacological Supportive Therapies
Exercise Therapies
Supervised Aerobic Exercise
Description & Purpose: Structured walking or cycling sessions (≥150 min/week) improve cardiovascular fitness and reduce cancer-related fatigue.
Mechanism: Enhances mitochondrial function and reduces pro-inflammatory cytokines, ameliorating fatigue and boosting quality of life jons-online.comIMR Press.
Resistance Training
Description & Purpose: Twice-weekly weight or resistance band exercises to maintain muscle mass and strength.
Mechanism: Stimulates protein synthesis in skeletal muscle and attenuates treatment-related sarcopenia, improving functional status ScienceDirectCancer.gov.
Combined Aerobic + Resistance (Mixed Modality)
Description & Purpose: Integrates both exercise types in a single program to maximize physical function gains.
Mechanism: Synergistically reduces fatigue and enhances overall quality of life through cardiometabolic and musculoskeletal adaptations Wikipedia.
Flexibility & Stretching Program
Description & Purpose: Daily stretching routines to maintain joint range of motion and reduce stiffness.
Mechanism: Improves circulation and connective tissue elasticity, preventing secondary musculoskeletal issues.
Mindful Movement (Tai Chi)
Description & Purpose: Slow, deliberate movements improving balance and reducing fall risk.
Mechanism: Combines light aerobic activity with proprioceptive training, enhancing musculoskeletal integrity and mental well-being.
Yoga (Hatha/Mixed Styles)
Description & Purpose: 150 min/week of yoga postures and breathwork to reduce fatigue and improve sleep.
Mechanism: Modulates hypothalamic–pituitary–adrenal (HPA) axis and autonomic balance, lowering cortisol levels and reducing inflammatory markers Wikipedia.
Pilates
Description & Purpose: Core-strengthening exercises to support posture and ocular surface comfort in patients with eye irritation.
Mechanism: Enhances deep trunk muscle activation, improving spinal stability and reducing overall musculoskeletal strain.
Mind-Body Therapies
Mindfulness-Based Stress Reduction (MBSR)
Description & Purpose: 8-week program of mindfulness meditation and gentle yoga to reduce distress.
Mechanism: Improves emotional regulation and decreases rumination by enhancing prefrontal cortex activity, reducing anxiety and depression in cancer patients Wikipedia.
Guided Imagery
Description & Purpose: Employs positive mental visualization to cope with discomfort and treatment anxiety.
Mechanism: Activates parasympathetic pathways, reducing pain perception and stress hormone release.
Progressive Muscle Relaxation (PMR)
Description & Purpose: Sequential tensing and relaxing of muscle groups to alleviate physical tension.
Mechanism: Interrupts the stress-tension cycle and attenuates sympathetic overactivity.
Biofeedback
Description & Purpose: Real-time monitoring of physiological signals (e.g., heart rate) to teach self-regulation.
Mechanism: Enhances autonomic flexibility, reducing anxiety and improving quality of life.
Music Therapy
Description & Purpose: Structured and receptive music sessions to elevate mood and distract from discomfort.
Mechanism: Modulates limbic system activity, reducing perceived pain and emotional distress.
Art Therapy
Description & Purpose: Creative expression sessions to process emotions and reduce anxiety.
Mechanism: Provides nonverbal emotional outlet and activates reward pathways, improving coping.
Acupuncture
Description & Purpose: Meridian-based needle therapy to relieve ocular discomfort and systemic side effects.
Mechanism: Stimulates endorphin release and modulates neuroinflammatory signaling.
Educational Self-Management
Disease Education Workshops
Description & Purpose: Group seminars on understanding lymphoma, treatment options, and self-care strategies.
Mechanism: Increases patient self-efficacy and adherence by empowering with knowledge, reducing anxiety PubMedCancer Care Ontario.
Symptom Tracking Diaries
Description & Purpose: Daily logs of symptoms, medication side effects, and triggers.
Mechanism: Facilitates early detection of complications and tailored clinician interventions.
Fatigue Management Training
Description & Purpose: Teaches energy conservation techniques and pacing activities.
Mechanism: Optimizes activity-rest balance, improving functional capacity.
Pain Coping Skills
Description & Purpose: CBT-based modules to reframe pain perceptions and use relaxation strategies.
Mechanism: Alters pain processing pathways via cortical modulation, reducing pain catastrophizing.
Medication Adherence Support
Description & Purpose: Pillbox use, reminder systems, and counseling to ensure consistent drug intake.
Mechanism: Reduces risk of subtherapeutic dosing and disease progression.
Peer Support Groups
Description & Purpose: Facilitated patient groups for shared experiences and social support.
Mechanism: Enhances emotional well-being and reduces isolation through communal coping.
Systemic Drug Treatments
Rituximab (Monoclonal anti-CD20 antibody)
Dosage & Schedule: 375 mg/m² IV once weekly for 4 weeks Dove Medical Press.
Class: Anti-CD20 monoclonal antibody.
Side Effects: Infusion reactions, infection risk, cytopenias.
Chlorambucil
Dosage & Schedule: 0.1 mg/kg orally daily for 6–12 weeks.
Class: Alkylating agent.
Side Effects: Myelosuppression, nausea, secondary malignancies.
Bendamustine
Dosage & Schedule: 90 mg/m² IV days 1–2 every 28 days.
Class: Alkylating agent/antimetabolite hybrid.
Side Effects: Neutropenia, fatigue, rash.
R-CHOP (Rituximab + CHOP)
Fludarabine
Dosage & Schedule: 25 mg/m² IV days 1–5.
Class: Purine analog.
Side Effects: Immunosuppression, neurotoxicity.
Ibrutinib
Dosage & Schedule: 560 mg PO daily.
Class: Bruton’s tyrosine kinase inhibitor.
Side Effects: Diarrhea, bleeding risk, atrial fibrillation.
Lenalidomide
Dosage & Schedule: 25 mg PO days 1–21 of 28-day cycle.
Class: Immunomodulatory agent.
Side Effects: Cytopenias, thromboembolism, rash.
Bortezomib
Dosage & Schedule: 1.3 mg/m² SC days 1,4,8,11 every 21 days.
Class: Proteasome inhibitor.
Side Effects: Peripheral neuropathy, thrombocytopenia.
Methotrexate (High-dose for CNS prophylaxis)
Dosage & Schedule: 1 g/m² IV every 2 weeks.
Class: Antimetabolite.
Side Effects: Mucositis, hepatotoxicity, renal injury.
Cyclophosphamide (Monotherapy)
Dosage & Schedule: 100 mg/m² PO days 1–5 every 28 days.
Class: Alkylating agent.
Side Effects: Myelosuppression, hemorrhagic cystitis.
Dietary Molecular Supplements
Curcumin
Dosage: 2,000–6,000 mg/day oral PMCAACR Journals.
Function & Mechanism: Induces lymphoma cell apoptosis via NF-κB inhibition and caspase activation.
Epigallocatechin-3-Gallate (EGCG)
Resveratrol
Vitamin D
Dosage: 2,000 IU/day.
Function & Mechanism: Regulates cell cycle and immune surveillance via VDR signaling.
Omega-3 Fatty Acids
Dosage: 2–4 g/day EPA/DHA.
Function & Mechanism: Anti-inflammatory through eicosanoid modulation.
Selenium
Dosage: 200 µg/day.
Function & Mechanism: Antioxidant enzyme cofactor, reduces oxidative DNA damage.
Quercetin
Dosage: 500 mg/day.
Function & Mechanism: Inhibits PI3K/Akt and ERK pathways, inducing cell cycle arrest.
Melatonin
Dosage: 3–10 mg/day at bedtime.
Function & Mechanism: Modulates circadian-immune axis, enhances chemotherapy sensitivity.
Probiotics (Lactobacillus spp.)
Dosage: ≥10⁹ CFU/day.
Function & Mechanism: Supports mucosal immunity and reduces gastrointestinal toxicity.
Beta-Glucans
Dosage: 250 mg/day.
Function & Mechanism: Stimulates macrophage and NK cell activity.
Regenerative & Stem-Cell–Based Therapies
Filgrastim (G-CSF)
Dosage: 10 µg/kg SC daily × 5 days for stem cell mobilization NatureScienceDirect.
Function & Mechanism: Stimulates neutrophil and CD34⁺ mobilization from bone marrow.
Pegfilgrastim
Dosage: 6 mg SC once per cycle.
Function & Mechanism: Long-acting G-CSF analog for stem cell mobilization.
Plerixafor (AMD3100)
Dosage: 0.24 mg/kg SC single dose, often with G-CSF Wikipedia.
Function & Mechanism: CXCR4 antagonist rapidly mobilizes CD34⁺ cells.
Axicabtagene Ciloleucel (Yescarta®)
Dosage: 2 × 10⁶ CAR⁺ T cells/kg, max 2 × 10⁸ cells U.S. Food and Drug Administration.
Function & Mechanism: Anti-CD19 CAR T-cell therapy inducing targeted lymphoma cell lysis.
Tisagenlecleucel (Kymriah®)
Dosage: 3 × 10⁶ CAR⁺ T cells/kg (range 0.2–6 × 10⁶) New England Journal of Medicine.
Function & Mechanism: Anti-CD19 CAR T cells that eradicate B-cell lymphoma clones.
Lisocabtagene Maraleucel (Breyanzi®)
Dosage: 1 × 10⁶ CAR⁺ T cells/kg Medscape Reference.
Function & Mechanism: Defined CD4⁺/CD8⁺ CAR T-cell product targeting CD19⁺ lymphoma cells.
Surgical Procedures
Incisional Biopsy
Procedure: Removal of a lesion wedge for histopathologic diagnosis.
Benefits: Minimal tissue loss, accurate grading. PMC
Excisional Biopsy
Procedure: Complete removal of small conjunctival lesion.
Benefits: Provides both diagnosis and local disease control. PMC
Local Surgical Excision with Margin
Procedure: Excision of lesion plus healthy margin, often combined with cryotherapy.
Benefits: Reduces local recurrence while preserving ocular surface. PMC
Cryotherapy-Assisted Excision
Procedure: Liquid nitrogen spray to freeze tumor margins after excision.
Benefits: Kills residual malignant cells and lowers recurrence rates to ~2% PubMed
Conjunctival Reconstruction (Amniotic Membrane Graft)
Procedure: Grafting after wide excision to restore ocular surface.
Benefits: Promotes healing, maintains tear film and comfort University of Miami Health System
Prevention Strategies
Treat Chlamydia psittaci Infection with doxycycline (100 mg PO BID × 3 weeks) to reduce antigenic stimulation Annals of Oncology.
Manage Hepatitis C aggressively with antiviral therapy to lower lymphoma risk PMC.
Avoid Tobacco: Eliminates carcinogens linked to systemic immune dysregulation World Health Organization.
Protect Against UV: Wear UV-blocking eyewear to reduce ocular surface inflammation World Health Organization.
Maintain Healthy Weight & Diet: Follow plant-forward, anti-inflammatory diet rich in whole grains, fruits, and vegetables World Cancer Research Fund.
Regular Physical Activity: ≥150 min/week to support immune surveillance epi.grants.cancer.gov.
Limit Alcohol: No more than one drink/day to reduce immunosuppressive effects World Health Organization.
Good Ocular Hygiene: Avoid eye rubbing; use clean towels and makeup tools Medical News Today.
Regular Eye Exams: Annual slit-lamp exam to detect early lesions University of Miami Health System.
Manage Autoimmune Conditions: Control Sjögren’s or thyroid eye disease to prevent chronic inflammation.
When to See a Doctor
Persistent “salmon-patch” lesion lasting >2 weeks Verywell Health
New lumps or thickening on conjunctiva
Visual changes (blur, double vision)
Eye pain or photophobia PMC
Unexplained conjunctival bleeding
Systemic symptoms (fever, weight loss)
“Do’s” & “Don’ts”
Do follow all treatment appointments and imaging schedules.
Do wear sunglasses with 100% UV protection when outdoors World Health Organization.
Do use preservative-free artificial tears to soothe irritation.
Do keep a symptom diary and report new changes.
Do maintain balanced nutrition and moderate exercise Cancer.org.
Avoid smoking and secondhand smoke World Health Organization.
Avoid rubbing or pressing on the eyes Medical News Today.
Avoid tanning beds or UV lamps.
Avoid unapproved supplements without physician approval.
Avoid missing follow-up ophthalmology appointments.
Frequently Asked Questions
What is conjunctival lymphoma?
A slow-growing B-cell malignancy of the conjunctiva’s lymphoid tissue journal.opted.org.Is it curable?
Yes—localized disease treated with radiotherapy or excision often yields >90% remission journal.opted.org.What are common symptoms?
Painless red “salmon patch,” irritation, occasional tearing.How is it diagnosed?
Biopsy (incisional/excisional) with histopathology and immunophenotyping PMC.What imaging is used?
CT/MRI of orbits and systemic staging (PET/CT) to rule out spread.What are treatment options?
Observation, surgical excision, cryotherapy, radiotherapy, immunochemotherapy PMCjournal.opted.org.What are side effects of radiotherapy?
Dry eye, cataract, rare retinopathy.Can it recur?
Recurrence rates <10% with combined modality; long-term follow-up essential.Is systemic therapy ever required?
Yes—if multicentric or disseminated disease, CHOP-based or immunotherapy regimens are used Dove Medical Press.How long is follow-up?
At least 5 years with periodic ophthalmic and systemic evaluation.Can it transform to high-grade lymphoma?
Rare (<5%), but surveillance biopsy may be needed if progression.Are there genetic markers?
t(11;18)(q21;q21) API2-MALT1 fusion seen in some cases.What lifestyle changes help?
Healthy diet, regular exercise, ocular hygiene, UV protection Mayo Clinic.Can supportive therapies help?
Exercise, mindfulness, self-management improve quality of life and may modulate immunity IMR PressWikipedia.When should I worry about systemic spread?
New lymphadenopathy, B symptoms, or bilateral ocular involvement warrant systemic work-up.
Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, geological location, weather and previous medical history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. Regular check-ups and awareness can help to manage and prevent complications associated with these diseases conditions. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. We always try to ensure that the content is regularly updated to reflect the latest medical research and treatment options. Thank you for giving your valuable time to read the article.
The article is written by Team RxHarun and reviewed by the Rx Editorial Board Members
Last Updated: July 19, 2025.


