Familial Hibernian Fever

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 5 min read
Patient Tools

Read, save, and share this guide

Use these quick tools to make this medical article easier to read, print, save, or share with a family member.

Familial Hibernian Fever
Patient Mode

Understand this article easily

Switch between simple English and easy Bangla patient notes. This is for education and does not replace a doctor consultation.

Familial Hibernian fever, also known as Familial Mediterranean fever (FMF), TRAPS (TNF receptor-associated periodic syndrome), is a rare genetic disorder caused by mutations in the TNFRSF1A gene. This gene provides instructions for making a protein called tumor necrosis factor recepto is a rare hereditary autoimmune disease...

For severe symptoms, danger signs, pregnancy, child illness, or sudden worsening, seek urgent medical care.

বাংলা রোগী নোট এখনো যোগ করা হয়নি। পোস্ট এডিটরে “RX Bangla Patient Mode” বক্স থেকে সহজ বাংলা সারাংশ যোগ করুন।

এই তথ্য শিক্ষা ও সচেতনতার জন্য। এটি ডাক্তারি পরীক্ষা, রোগ নির্ণয় বা প্রেসক্রিপশনের বিকল্প নয়।

Article Summary

Familial Hibernian fever, also known as Familial Mediterranean fever (FMF), TRAPS (TNF receptor-associated periodic syndrome), is a rare genetic disorder caused by mutations in the TNFRSF1A gene. This gene provides instructions for making a protein called tumor necrosis factor recepto is a rare hereditary autoimmune disease characterized by recurrent episodes of fever, pain and swelling in the abdomen, chest or joints. It is an inherited disorder...

Key Takeaways

  • This article explains Causes in simple medical language.
  • This article explains Symptoms in simple medical language.
  • This article explains Diagnosis in simple medical language.
  • This article explains Treatment in simple medical language.
Educational health guideWritten for patient understanding and clinical awareness.
Reviewed content workflowUse writer and reviewer profiles for stronger trust.
Emergency safety firstUrgent warning signs are highlighted below.

Seek urgent medical care if you notice

These warning signs are general safety guidance. Local emergency numbers and clinical judgment should always come first.

  • Severe symptoms, breathing difficulty, fainting, confusion, or rapidly worsening illness.
  • New weakness, severe pain, high fever, or symptoms after a serious injury.
  • Any symptom that feels urgent, unusual, or unsafe for the patient.
1

Emergency now

Use emergency care for severe, sudden, rapidly worsening, or life-threatening symptoms.

2

See a doctor

Book a professional medical evaluation if symptoms persist, worsen, recur often, affect daily activities, or occur in a high-risk patient.

3

Learn safely

Use this article to understand possible causes, tests, treatment options, prevention, and questions to ask your clinician.

Before reading

RX Patient Tools

Use these quick guides before reading the article, or return to them when you need help preparing questions for a doctor.

Start here Choose the right pathway for symptoms, reports, medicines, or urgent warning signs. Disease article roadmap Read this topic step by step: meaning, symptoms, warning signs, diagnosis, treatment, prevention, and follow-up. Treatment planner Prepare questions about treatment choices, benefits, risks, side effects, and follow-up. Family & caregiver guide Organize symptoms, reports, medicines, questions, and follow-up safely. Nutrition & diet guide Prepare food, hydration, supplement, and medicine-timing questions safely. Prevention guide Organize risk factors, protective habits, screening, and warning signs. Recovery guide Prepare a safe plan for activity, rehabilitation, warning signs, and follow-up.
Definition

Familial Hibernian fever, also known as Familial Mediterranean fever (FMF), TRAPS (TNF receptor-associated periodic syndrome), is a rare genetic disorder caused by mutations in the TNFRSF1A gene. This gene provides instructions for making a protein called tumor necrosis factor recepto is a rare hereditary autoimmune disease characterized by recurrent episodes of fever, pain and swelling in the abdomen, chest or joints. It is an inherited disorder that is most commonly found in people of Mediterranean, Middle Eastern and Armenian descent. The exact cause of FMF is not known, but it is believed to be related to a genetic mutation in the MEFV gene, which regulates infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation in the body. The symptoms typically begin in childhood or early adulthood and may worsen over time. Treatment typically involves the use of anti-inflammatory medications, such as colchicine, to reduce the frequency and severity of symptoms.

Causes

The MVK gene provides instructions for making an enzyme called mevalonate kinase, which is involved in the production of cholesterol and other important substances in the body.

When the MVK gene is mutated, it leads to a deficiency of mevalonate kinase and results in increased infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation and damage to various tissues in the body. This leads to the development of Familial Hibernian fever.

The specific causes of Familial Hibernian fever are still unknown, but it is thought to be related to a combination of genetic and environmental factors. Some common symptoms of the disease include:

Symptoms

Familial Hibernian fever, also known as TRAPS (TNF receptor-associated periodic syndrome), is a rare genetic autoimmune disease that affects multiple systems in the body. The main symptoms of TRAPS are:

  1. Fever: Recurrent fevers that can last for several days and can be accompanied by chills, fatigue, and body aches.
  2. infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">Inflammation: Inflammation in various parts of the body, including the abdomen, chest, skin, and joints.
  3. Abdominal pain: Severe abdominal pain that is usually accompanied by nausea, vomiting, and diarrhea.
  4. Joint pain: Pain and stiffness in the joints, which can lead to joint swelling and redness.
  5. Rash: A skin rash that is often accompanied by itching and burning.
  6. Eye infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation: Inflammation in the eyes that can cause redness, pain, and blurred vision.
  7. Mouth ulcers: Recurrent mouth ulcers that can be painful and cause difficulty eating and speaking.

These symptoms can occur unpredictably and can be severe, leading to hospitalization and disability in some cases. A proper diagnosis is important for effective treatment and management of TRAPS.

Diagnosis

Diagnosis of Familial Hibernian fever typically involves a combination of the following tests:

  1. Medical history and physical examination: The doctor will ask about the patient’s symptoms and any family history of similar conditions.
  2. Blood tests: Blood tests may be done to check for elevated levels of certain markers, such as C-reactive protein (CRP) or white blood cells (WBCs), that suggest inflammation.
  3. Genetic testing: A genetic test can confirm the presence of mutations in the TNFRSF1A gene, which is associated with TRAPS.
  4. Imaging studies: Imaging studies, such as X-rays or MRI, may be done to look for signs of joint damage or other abnormalities.
  5. Biopsy: In some cases, a biopsy of affected tissue may be done to confirm the diagnosis and help rule out other conditions.

A definitive diagnosis of Familial Hibernian fever requires a combination of clinical, laboratory, and genetic findings.

Treatment

The main treatment for FHf is non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, which can help reduce the symptoms of inflammation and fever.

In severe cases, corticosteroids may be used to reduce inflammation and suppress the immune system. Other medications that may be used include immunosuppressants such as azathioprine or methotrexate, which can help reduce the severity of symptoms and prevent flare-ups.

In some cases, antibiotics may be prescribed to treat any secondary infections that may occur as a result of the weakened immune system.

It is important for individuals with FHf to be closely monitored by a healthcare provider and to receive regular check-ups to monitor the progression of the condition and adjust treatment as needed.

It is also important for individuals with FHf to maintain a healthy diet, exercise regularly, and manage stress levels to help prevent flare-ups and manage symptoms.

  1. https://www.ncbi.nlm.nih.gov/books/NBK11733/
  2. https://www.ncbi.nlm.nih.gov/books/NBK208/
  3. https://www.ncbi.nlm.nih.gov/books/NBK212/
  4. https://www.ncbi.nlm.nih.gov/books/NBK92761/
  5. https://www.ncbi.nlm.nih.gov/books/NBK11733/
  6. https://www.nccih.nih.gov/health/skin-conditions-at-a-glance
  7. https://www.aad.org/public/diseases/a-z
  8. https://medlineplus.gov/skinconditions.html
  9. https://www.aad.org/about/burden-of-skin-disease
  10. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  11. https://www.cdc.gov/niosh/topics/skin/default.html
  12. https://www.skincancer.org/
  13. https://www.jaad.org/
  14. https://www.psoriasis.org/about-psoriasis/
  15. https://books.google.com/books?
  16. https://www.niams.nih.gov/health-topics/skin-diseases
  17. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  18. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  19. https://dermnetnz.org/topics
  20. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  21. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  22. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  23. https://www.nibib.nih.gov/
  24. https://rxharun.com/resources/category/resources/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/
  25. https://www.nei.nih.gov/
  26. https://en.wikipedia.org/wiki/List_of_skin_conditions
  27. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  28. https://en.wikipedia.org/wiki/Skin_condition
  29. https://oxfordtreatment.com/
  30. https://www.nidcd.nih.gov/health/
  31. https://consumer.ftc.gov/articles/w
  32. https://www.nccih.nih.gov/health
  33. https://catalog.ninds.nih.gov/
  34. https://www.aarda.org/diseaselist/
  35. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  36. https://www.nibib.nih.gov/
  37. https://www.nia.nih.gov/health/topics
  38. https://www.nichd.nih.gov/
  39. https://www.nimh.nih.gov/health/topics
  40. https://www.nichd.nih.gov/
  41. https://www.niehs.nih.gov
  42. https://www.nimhd.nih.gov/
  43. https://www.nhlbi.nih.gov/health-topics
  44. https://obssr.od.nih.gov/
  45. https://www.nichd.nih.gov/health/topics
  46. https://rarediseases.info.nih.gov/diseases
  47. https://beta.rarediseases.info.nih.gov/diseases
  48. https://orwh.od.nih.gov/

Doctor visit helper

Prepare before seeing a doctor

A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

General physician, medicine specialist, pediatrician for children, or emergency care if severe.

What to tell the doctor

  • Write fever days, highest temperature, chills, rash, cough, urine burning, diarrhea, travel, dengue/malaria exposure.
  • Bring medicine history, especially antibiotics already taken.

Questions to ask

  • Is this likely viral, bacterial, dengue, malaria, typhoid, UTI, pneumonia, or another infection?
  • Which tests are needed today?
  • Do I need antibiotics, or should I avoid them?

Tests to discuss

  • Temperature and hydration assessment
  • CBC with platelet count when dengue or infection is suspected
  • Urine test if urinary symptoms
  • Malaria/dengue/typhoid/COVID tests depending on local risk and symptoms

Avoid these mistakes

  • Avoid self-starting antibiotics.
  • Avoid aspirin in suspected dengue or children unless a doctor advises.
  • Seek urgent care for confusion, breathing trouble, dehydration, stiff neck, seizure, or persistent very high fever.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Drink safe fluids and monitor temperature.
  • In dengue-prone areas, discuss CBC and platelet count when fever persists or warning signs appear.
  • Use tepid sponging for high fever discomfort; avoid ice-cold bathing.

OTC medicine safety

  • For fever, common fever medicine may be discussed with a clinician or pharmacist.
  • Avoid aspirin/ibuprofen-like medicines in suspected dengue unless a doctor says it is safe.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Fever with breathing difficulty, confusion, repeated vomiting, bleeding, severe weakness, stiff neck, or dehydration needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Medicine doctor / pediatrician for children / qualified clinician
Tests to discuss with doctor
  • Temperature chart and hydration assessment
  • CBC with platelet count if fever persists or dengue/other infection is possible
  • Urine test, malaria/dengue tests, chest evaluation, or blood culture only when clinically indicated
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?
  • Do I need antibiotics, or is this more likely viral?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Familial Hibernian Fever

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Very drowsy/confused, severe breathing difficulty, stiff neck, seizure, severe dehydration, or persistent vomiting
  • Bleeding, severe abdominal pain, very low urine, or dengue warning signs during fever season
Doctor / service to discuss: Medicine doctor, pediatrician for children, or qualified clinician.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Discuss temperature chart, hydration, CBC with platelet count when needed, urine test, dengue/malaria testing, or other tests based on local disease risk and examination.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.
  • Do not start antibiotics blindly for every fever; many fevers are viral and need correct assessment.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

RX Patient Help

Ask a health question safely

Write your symptom story. A health professional or site editor can review it before any answer is prepared. This box is not for emergency care.

Emergency first: Severe chest pain, breathing trouble, unconsciousness, stroke signs, severe injury, heavy bleeding, or rapidly worsening symptoms need urgent local medical care now.

Frequently Asked Questions

Is this article a replacement for a doctor?

No. It is educational content only. Patients should consult a qualified clinician for diagnosis and treatment.

When should I seek urgent care?

Seek urgent care for severe symptoms, rapidly worsening condition, breathing difficulty, severe pain, neurological changes, or any emergency warning sign.

Continue exploring

Explore this topic across the RX Medical Library

Open a focused A–Z pathway or continue with closely related indexed articles. These links are educational and do not replace personal medical care.

Search this topic
Diseases A–Z Drugs A–Z Lab Tests A–Z Cancer A–Z
Diseases A–Z

Abdominal Fascia Infection

Abdominal fascia infection is a serious condition that involves the inflammation or infection of the connective…

More from this topic
  1. High Scapula

    DefinitionHigh scapula is a condition where one shoulder blade sits higher than normal on the back from birth. Doctors usually call it Sprengel deformity, congenital? high...

    April 2, 2026 • Degenerative Bones, Joints, and Spine Care (A - Z)
  2. Congenital Elevation of Scapula

    DefinitionCongenital? elevation of scapula means a baby is born with one shoulder blade sitting higher than normal. The shoulder blade is called the scapula. In this...

    April 2, 2026 • Degenerative Bones, Joints, and Spine Care (A - Z)
  3. Isolated Congenital Elbow Dislocation

    DefinitionIsolated congenital? elbow dislocation is a very rare condition present from birth. In most medical papers, the more exact name is congenital? radial head dislocation, because...

    April 2, 2026 • Gastrointestinal, Pelvic & Liver Disease, (A - Z)
  4. Congenital Radial Head Dislocation

    DefinitionCongenital? radial head dislocation means the top part of the radius bone, called the radial head, is out of its normal place at the elbow from...

    April 2, 2026 • Degenerative Bones, Joints, and Spine Care (A - Z)
  5. Congenital Elbow Dislocation

    DefinitionCongenital? elbow dislocation usually means a baby is born with abnormal alignment around the elbow joint, most often a congenital? radial head dislocation. It is rare,...

    April 2, 2026 • Degenerative Bones, Joints, and Spine Care (A - Z)
  6. Congenital Dyserythropoietic Anemia, Type III

    DefinitionCongenital? dyserythropoietic anemia?, type III, also called CDA type III, is a very rare inherited blood disease. In this disease, the bone marrow tries to make...

    April 2, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  7. Congenital Dyshaematopoietic Anemia

    DefinitionCongenital? dyshaematopoietic anemia? is more commonly called congenital? dyserythropoietic anemia?, or CDA. It is a rare inherited blood disorder. In this disease, the bone marrow makes...

    April 1, 2026 • Rx Blood, Metabolism, and Infectious Diseases (A - Z)
  8. GUCY2C Congenital Diarrhea

    DefinitionGUCY2C congenital? diarrhea? is a very rare inherited bowel disease that usually starts before birth or in the first days or weeks of life. It happens...

    March 31, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  9. Congenital Diarrhea Caused by Mutation in GUCY2C

    DefinitionCongenital? diarrhea? caused by mutation in GUCY2C is a very rare inherited bowel disease in which a change in the GUCY2C gene makes the intestine send...

    March 31, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  10. Chronic Infantile Diarrhea Due to Guanylate Cyclase 2C Overactivity

    DefinitionChronic? infantile diarrhea? due to guanylate cyclase 2C overactivity is a very rare inherited bowel disease. It usually starts very early in life, often in infancy,...

    March 31, 2026 • Gastrointestinal, Pelvic & Liver Disease, (A - Z)