Mistletoe, Mystyldene, Devil’s Fuge, European mistletoe, Viscum, Birdlime

Mistletoe is the species of parasitic plants of Loranthaceae, Santalaceae, and Misodendraceae families. The species are used for decorations during Christmas and are related to the holiday tradition of kissing. It is a popular plant sprig where people kiss beneath at the time of Christmas. For centuries, Mistletoe has been used as an all-purpose herbal aid.

Mistletoe is grown on several woody hosts in an array of wooded habitats that extends from tropics to temperate regions. Besides its geographical range, it is available on gymnosperms and broadleaved trees. Its common hosts are poplar, apple, lime, and hawthorn in the UK. Commonly it is hemiparasitic meaning it depends on its host for mineral nutrients and water. It has the ability to photosynthesize due to the presence of green leaves and stems. Viscum album is dioecious and produces male and female flowers on separate plants.

History

Mistletoes are used in Europe for medicinal purposes for centuries as a treatment for infertility, epilepsy, pain?, swelling?, stiffness?, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।" data-rx-term="arthritis" data-rx-definition="Arthritis means joint inflammation causing pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।">arthritis? and hypertension?. According to naturalist Gaius Plinius Secundus and Roman author, Druids (Celtic priests) revered oak tree and mistletoe that grew upon it. Except for green boughs of Mistletoes, all sacred oaks were bare at the winter celebration of Samhain which was considered as a sign of eternal fertility. A sprig of Mistletoe was placed by Celts above the door of their houses. The Austrian anthroposophical spiritual leader in 1921 reported that Mistletoe is used for treating cancer.

Plant

Mistletoe is an evergreen and woody plant which grows up to the height of 1 m with abundant and regularly forked branches. Stems are (12-39 inches)30-100 centimeters long with dichotomous branching. The leaves occur in pairs. Leaves measures about 5 to 7 cm long, 0.8 to 2.5 cm (0.31–0.98 inches) broad which is narrowly oval with slightly curved in outline. Leaves are leathery textured and are matt yellowish to green in color. The plant bears flowers from February to April. Flowers have yellowish-green, four small petals. Flowers give way to white berries which are 1 cm in diameter and ripens in November and December. Fruit have sticky and glutinous pulp. The flowers are pollinated by insects and seeds are dispersed by birds.

Flower and Fruit

Flowers are yellowish to green in color which appears in small, insignificant and 3 to 5 flowered clusters. Stamens are fused with tips. Female flowers is small, have four tepals along with a thick stigma on-die short style. The fruit becomes white to yellowish or orange when ripened with one to two oval or angular seeds.

Leaves

Leaves are alternate, evergreen, coriaceous, sessile, and lanceolate or lanceolate to spatulate in shape. It is matt yellowish to green and measures about 5 to 7 cm long.

Health Benefits of Mistletoe

A mistletoe is a hemiparasitic plant that penetrates into branches and absorbs water and nutrients to survive. There are more than 900 species that belong to 73 different genera. Mistletoe extract has organic compounds and chemicals which have been used for treating cancer in these recent years. Recent studies have shown its anticancer effects. Mistletoe helps to treat nervous conditions and epilepsy. The calming effects in Mistletoe help to lower blood pressure. It is a parasitic shrub that grows on the stem of broad-leaved ones such as apple, lime, and poplar trees. Scientifically known as Viscum Album, this species is used for medicinal purposes. It is used to make tinctures and also drunk as tea. Medically, it is also used in injectable form. The extracts have a low content of Mistletoe which lowers the chances of toxicity.

1. Cancer treatment

The extracts of Mistletoe are used as a medicine for cancer. Its extracts contain solubilized triterpene acids or lectins which inhibit cell proliferation and also induced apoptosis. Research shows direct association of its extract with anti-cancer activity. It causes apoptosis in cancer cells. Research has associated Mistletoe extract for higher overall quality of life for patients, healthier blood counts, and tumor reduction. (1)

2. Cure for insulin? is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">diabetes?

Mistletoe is the species of the Santalaceae family that possess therapeutic properties for several health problems such as insulin? is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">diabetes?. The study was conducted on rat model with diabetes-induced streptozotocin in order to evaluate the effect of Mistletoe on an antioxidant system and lipid peroxidation. Research shows that it is able to reduce levels of blood glucose and stimulate the production of insulin in pancreatic cells, lessens the severity of the disorder and regulates the levels. It is an aid for those that suffer from diabetes. (2)

3. Relaxes muscles

Mistletoe has an inhibitory effect on smooth muscles. This plant is effective to manage cardiovascular disorders and hyperactive gut. The conducted study shows a pharmacological base of smooth muscle relaxant effect of Mistletoe in gut and also vascular preparations. Viscum album has vasodilatory and antispasmodic effects. The current study shows the medicinal use of Mistletoe in diarrhea?, colic and hypertension?. Still further studies need to be conducted to know underlying molecular mechanisms. Apply this herb as a poultice which helps to provide relief from pain? and is also useful to aid painful and inflammatory health conditions such as gout and sciatica?. It has good effect on muscles found in arteries, intestines and uterus. These properties help to calm muscles which assist in health conditions such as indigestion and dyspepsia. (3)

4. Cardiovascular health

Besides vasorelaxant and antihypertensive activity, it possesses cardiovascular effects and Nitric oxide pathway upregulation has been suggested to be the underlying mechanism. Nitric oxide has a vital role in the pathophysiology of heart failure. The effects on cardiac systolic function are still unclear. Mistletoe helps to lower blood pressure that prevents pressure on the cardiovascular system which prevents the chances of shrinkage of arteries that induce atherosclerosis. It reduces the chances of lethal conditions such as coronary heart disease and stroke?. (4)

5. Treat DNA damage

Mistletoe is a semiparasitic plant which is grown on trees and used for treating diseases in complementary and traditional therapy. Some activities of Mistletoe depend on host trees such as apoptosis-inducing, antioxidant and anticancer activities. The present study examines the comparative effects of methanolic extracts of Mistletoe which is grown on lime trees, locust trees and hedge maple tree. Mistletoe extracts help to induce significantly. All the extracts are protected against nuclear DNA damage. Results show that methanolic extracts of Mistletoe prevent oxidative DNA damage and its activity is dependent on a host tree. (5)

6. Neutralizes tumor

Results of the study provide anti-cancer effects of preparations of Mistletoe. Additionally, the results acquired with the Vitro assay point to the possible role for Mistletoe lectins to counteract tumor-induced immunosuppression. Further studies are still need to be conducted to clarify it. (6)

7. Normalizes blood pressure

Mistletoe extract helps to lower blood pressure that assist to ease stress and tendon?. সহজ বাংলা: মাংসপেশি/টেনডনে টান।" data-rx-term="strain" data-rx-definition="A strain is injury to a muscle or tendon. সহজ বাংলা: মাংসপেশি/টেনডনে টান।">strain? on cardiovascular system. It also lowers the chances of atherosclerosis. An extract of Mistletoe prevents the chances of heart attacks, strokes, and coronary heart disease. It slows pulse which reduces heart exertion. Its affects blood pressure which helps to treat hypertension?. It prevents the chances of atherosclerosis and plaque? buildup in arteries that results in life-threatening and dangerous heart conditions.

8. Promote sound sleep

Mistletoe has a nervine agent and is helpful for those who suffer from restlessness or insomnia. Mistletoe impact has chemical components which have an impact on the release of neurotransmitters that helps to calm and soothe the nervous system and also provides sound sleep.

9. Respiratory problems

Mistletoe has nerve soothing properties that calm the respiratory system in cause of irritation and distress. Mistletoe is able to calm sore throats, bronchial infection?, or irritation, often causing pain?, swelling?, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation?, and coughing. It also lowers tightness in the chest and lowers discomfort. Wheezing and coughing occur in asthmatic attacks and mental distress and panic. It bothers neural connections and soothes the body and mind. Historically it has been used to soothe distress and irritation in the respiratory system. It is useful for bronchitis and chest tightness. It calms the symptoms of mental anxiety and distress.

10. Strengthen immunity?

Mistletoe is helpful for enhancing immune system. The herb is appreciated for treatment of cancer. It boosts immunity? and prevents the chances of outside illness. The antioxidant, antibacterial and antiviral activities of Mistletoe herb defense the body from illness and maintain immune health. It also prevents further illness. A strong immune system maintains overall health and is able to improve the natural defenses of the body.

Traditional uses

• Mistletoes are well known as a cardiac depressant.
• It is used for treating arteriosclerosis, high blood pressure, hypertensive pain? in the head or upper neck. সহজ বাংলা: মাথাব্যথা।" data-rx-term="headache" data-rx-definition="Headache means pain in the head or upper neck. সহজ বাংলা: মাথাব্যথা।">headache?, nervous tachycardia?, hysteria, and chorea.
• The preparations of Mistletoes are used as a treatment for various types of cancer.
• It is used for lowering blood pressure, heart rate, promoting sleep, and ease anxiety.
• If used in low doses, it provides relief from headaches, panic attacks and improves concentration.
• The mistletoe plant is used to cure internal hemorrhages, treat cancers of the ovaries, lungs, and stomach.
• Use it externally for treating rheumatism, pain?, swelling?, stiffness?, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।" data-rx-term="arthritis" data-rx-definition="Arthritis means joint inflammation causing pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।">arthritis?, varicose veins, leg ulcers and chilblains.
• An extract of Mistletoe affects the immune system in HIV patients.
• It is useful for rheumatism, bronchitis, preventing capillary hemorrhage and chronic? skin disorders.
• Apply it externally for milk scall in children and mild seborrheic skin diseases.
• It has been used for treating cancer for decades.
• Mistletoe is useful for treating coughs, headaches, menopausal symptoms, hypertension?, rheumatism, stiffness?, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।" data-rx-term="arthritis" data-rx-definition="Arthritis means joint inflammation causing pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।">arthritis? and epileptic seizures.
• It inhibits thrombosis formation and decreases platelet aggregation.
• Mistletoe tea helps to lower blood pressure and circulatory problems such as arteriosclerosis and a weak heart.
• It strengthens metabolism and the digestive system.
• Use the cold infusion made from Mistletoe as poultice and bathing.
• It is helpful for ulcers of the lower legs and varicose veins.
• Mistletoe infusions are used to treat eczema.

Precautions  

• Mistletoe should not be used in case of allergy, high fever, acute inflammatory conditions, chronic progressive conditions such as tuberculosis.
• An injection of Mistletoe can increase the body temperature.
• It should not be used by breastfeeding mothers and pregnant women as it stimulates uterine contractions.
• It might cause hepatitis.
• It could interfere with allopathic drugs for heart disease, high blood pressure, anticoagulants and antidepressants.
• The tuberculosis patients and allergic people should avoid its use.
• Its common side effects are chills, fever, reaction at injection site, elevated white blood cell count and hypersensitivity.
• Vomiting, diarrhea, low blood pressure, headache, fainting or passing out, low heart rate, itching, increased blood sugar and rash indicates toxicity.
• Leaves, berries and stems of Mistletoe could be harmful for humans if ingested.
• Side effects are mild fever, change in pupil size, slow pulse, dehydration from diarrhea, nausea, hallucinations, seizures and delirium.

References