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The exact mechanism leading to ureteritis cystica remains unclear, but it is believed to result from chronic infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation or irritation of the urothelium (the lining of the urinary tract). This persistent inflammation may cause the epithelial cells to proliferate and form cystic structures.
Structure, Blood Supply, and Nerve Supply of the Ureters
Each ureter is a muscular tube approximately 25–30 cm long that transports urine from the kidney to the bladder. The wall of the ureter consists of three layers:
- Mucosa: The innermost layer, lined with transitional epithelium.
- Muscularis: A middle layer of smooth muscle fibers that facilitate peristalsis.
- Adventitia: The outermost layer, composed of connective tissue.
The ureters receive their blood supply from various arteries, including the renal, gonadal, and common iliac arteries. Venous drainage corresponds to these arterial sources. The nerve supply is derived from the autonomic nervous system, with sympathetic input from the lower thoracic and upper lumbar spinal segments and parasympathetic input from the sacral spinal segments.
Types of Ureteritis
Ureteritis can be classified based on its characteristics:
- Ureteritis Cystica: Characterized by multiple small cysts within the ureteral wall.
- Ureteritis Glandularis: Involves glandular metaplasia of the urothelium, where the epithelial cells transform into a gland-like structure
- Eosinophilic Ureteritis: Marked by eosinophilic infiltration, often associated with allergic reactions or parasitic infections.
- IgG4-Related Ureteritis: A rare form associated with IgG4-related disease, characterized by lymphoplasmacytic infiltration and chronic injury or inflammation. সহজ বাংলা: অতিরিক্ত দাগের মতো টিস্যু তৈরি হওয়া।" data-rx-term="fibrosis" data-rx-definition="Fibrosis means excess scar-like tissue formation after chronic injury or inflammation. সহজ বাংলা: অতিরিক্ত দাগের মতো টিস্যু তৈরি হওয়া।">fibrosis.
Causes
The exact cause of ureteritis cystica is not well-defined, but several factors may contribute:
- Chronic Urinary Tract Infections (UTIs): Repeated infections can lead to persistent infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
- Mechanical Irritation: Conditions like kidney stones can cause continuous irritation.
- Obstruction: Blockages in the urinary tract can result in infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
- Tumors: Although less common, tumors can cause local irritation and infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
- Foreign Bodies: The presence of foreign materials can induce an inflammatory response.
- Endometriosis: Tissue similar to the uterine lining grows outside the uterus, including on the ureters, leading to infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
- Radiation Therapy: Previous radiation can damage tissues and cause infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
- Chemotherapy: Certain drugs can have inflammatory side effects.
- Autoimmune Diseases: Conditions like lupus can involve the urinary tract.
- IgG4-Related Disease: A systemic condition that can affect various organs, including the ureters
- Parasitic Infections: Though rare, parasites can cause ureteral infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
- Allergic Reactions: Hypersensitivity to certain substances can lead to inflammation.
- Metabolic Disorders: Conditions like diabetes can increase the risk of infections and inflammation.
- Congenital Abnormalities: Structural defects present from birth can lead to chronic irritation.
- Neurogenic Bladder: Dysfunction in bladder nerve supply can cause urinary stasis and inflammation.
- Prolonged Catheterization: Long-term use of urinary catheters can introduce infections.
- Bladder Exstrophy: A rare condition where the bladder is exposed outside the abdomen, leading to chronic inflammation.
- Urethral Strictures: Narrowing of the urethra can cause urinary retention and inflammation.
- Pelvic Inflammatory Disease: Infections of the reproductive organs can spread to the urinary tract.
- Renal Tuberculosis: A rare form of tuberculosis that affects the kidneys and ureters.
