Intravitreal Injection – Indications, Procedure, Risk

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Retinal vein occlusion-intravitreal injection; Triamcinolone-intravitreal injection; Dexamethasone-intravitreal injection; Lucentis-intravitreal injection; Avastin-intravitreal injection; Bevacizumab-intravitreal injection; Ranibizumab-intravitreal injection; Anti-VEGF medications-intravitreal injection An intravitreal injection is a shot of medicine into the eye. The inside of the eye is filled with a jelly-like fluid (vitreous). During this procedure, your health care provider injects medicine into the vitreous, near the retina at the back of the eye. The medicine...

Key Takeaways

  • This article explains Description in simple medical language.
  • This article explains Why the Procedure is Performed in simple medical language.
  • This article explains Risks in simple medical language.
  • This article explains Before the Procedure in simple medical language.
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Definition

Retinal occlusion-intravitreal injection; Triamcinolone-intravitreal injection; Dexamethasone-intravitreal injection; Lucentis-intravitreal injection; Avastin-intravitreal injection; Bevacizumab-intravitreal injection; Ranibizumab-intravitreal injection; Anti-VEGF medications-intravitreal injection

An intravitreal injection is a shot of medicine into the eye. The inside of the eye is filled with a jelly-like fluid (vitreous). During this procedure, your health care provider injects medicine into the vitreous, near the at the back of the eye. The medicine can treat certain eye problems and help protect your vision.

Description

The procedure is done in your health care provider’s office. It takes about 15 to 30 minutes.

  • Drops will be placed in your eyes to widen (dilate) the pupils.
  • You will lie face up in a comfortable position.
  • Your eyes and eyelids will be cleaned.
  • Numbing drops will be placed in your eye.
  • A small device will keep your eyelids open during the procedure.
  • You will be asked to look toward the other eye.
  • Medicine will be injected into your eye with a small needle. You may feel pressure, but not .
  • drops may be placed in your eye.

Why the Procedure is Performed

You may have this procedure if you have:

  • Macular degeneration: An eye disorder that slowly destroys sharp, central vision
  • Macular : or thickening of the macula, the part of your eye that provides sharp, central vision
  • Diabetic retinopathy, can cause new, abnormal blood vessels to grow in the retina, the back part of your eye
  • Swelling and within the eyeball (uveitis)
  • Retinal vein occlusion: A blockage of the that carry blood away from the retina and out of the eye
  • Infections in the inside of the eye (endophthalmitis)

Risks

Side effects are rare, and many can be managed. They may include:

  • Increased pressure in the eye
  • Inflammation
  • Bleeding
  • Damage to the retina or surrounding nerves or structures
  • Vision loss
  • Loss of the eye (very rare)
  • Side effects from the medicines that are used

Discuss the risks of specific medicines used in your eye with your provider.

Before the Procedure

Tell your provider about:

  • Any health problems
  • Medicines you take, including any over-the-counter medicines
  • Any allergies
  • Any bleeding tendencies

After the Procedure

  • You may feel a few sensations in the eye such as pressure and grittiness, but there should not be a pain.
  • Sometimes a little bleeding can occur on the white of the eye. This is normal and will go away.
  • You may see eye floaters in your vision. They will improve over time.
  • DO NOT rub your eyes for several days.
  • Avoid swimming for at least 3 days.
  • Use eye drop medicine as directed.

Report any eye pain or discomfort, redness, sensitivity to light, or changes in your vision to your provider right away.

Schedule a follow-up appointment with your provider as directed.

Outlook ()

Your vision may remain stable or improve after the procedure. You may need more than one injection.

 

American Academy of Ophthalmology. How to give intravitreal injections. 2013. www.aao.org/publications/eyenet/201304/upload/April-2013-Ophthalmic-Pearls-How-to-Give-Intravitreal-Injections.pdf. Accessed Oct. 6, 2014.

American Academy of Ophthalmology Retina/Vitreous Panel. Preferred Practice Pattern Guidelines. Age-Related Macular Degeneration. San Francisco, CA: American Academy of Ophthalmology; 2014. Available at: www.aao.org/ppp. Accessed August 29, 2013.

Mitchell P, Wong TY, Diabetic Macular Edema Treatment Guideline Working Group. Management paradigms for diabetic macular edema. Am J Ophthalmol . 2014 Mar;157(3):505-13.e1-8. PMID: 24269850 www.ncbi.nlm.nih.gov/pubmed/24269850 .

Peyman GA, Lad EM, Moshfeghi DM. Intravitreal injection of agents. Retina. 2009;29(7):875-912.PMID: 19584648 www.ncbi.nlm.nih.gov/pubmed/19584648 .

Sanborn GE, Magargal LE. Venous Occusive Disease of the Retina. In: Tasman W, Jaeger EA, eds. Duane’s Ophthalmology . 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol 3;chap 15.

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A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
  • Bring old prescriptions, investigation reports, and current medicines.
  • Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
  • Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

  • What is the most likely cause of my symptoms?
  • Which danger signs mean I should go to hospital quickly?
  • Which tests are necessary now, and which can wait?
  • How should I take medicines safely and what side effects should I watch for?
  • When should I come for follow-up?

Tests to discuss

  • Vital signs: temperature, pulse, blood pressure, oxygen saturation
  • Basic physical examination by a clinician
  • CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

  • Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
  • Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
  • Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Avoid heavy lifting, sudden bending, and prolonged bed rest.
  • Use comfortable posture and gentle movement as tolerated.
  • Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
  • Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

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Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Doctor / qualified healthcare provider
Tests to discuss with doctor
  • Basic vital signs: temperature, pulse, blood pressure, oxygen level if needed
  • Relevant blood, urine, imaging, or specialist tests only after clinical assessment
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Intravitreal Injection – Indications, Procedure, Risk

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.