Dibucaine is a quinoline derivative and amino amide with anesthetic activity. Dibucaine reversibly binds to and inactivates sodium channels in the neuronal cell membrane. Inhibition of sodium channels prevents the depolarization of nerve cell membranes and inhibits subsequent propagation of impulses along the course of the nerve, thereby limiting the excitation of nerve endings. This results in loss of sensation.
Another Name of Cinchocaine
- Dibucaine hydrochloride
- Dibucaine HCl
- Cinchocaine HCL
- Cinchocaine hydrochloride
- cinchoninamide
- cinchoninamide
- cinchoninamide
- ethyl-4-quinoline carboxamide
- 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
- 2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide
- 2-N-butoxy-N-(2-diethyl aminoethyl cinchoninamide
- Cinchocaine
- Cinchocainum
- Cincocainio
- Dibucaine
- butoxycinchoninamide
- α-butyloxycinchonic acid-γ-diethylethylenediamine
- α-butyloxycinchoninic acid diethylethylenediamide
Mechanism of Action of Cinchocaine
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Indications of Cinchocaine
- For the production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
- The monohydrochloride salt of cinchocaine. It is used in creams, ointments, and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
- Topical anesthetics are indicated to relieve pain, pruritus, and inflammation associated with minor skin disorders, including burns, minor, including sunburn; bites (or stings), insect; dermatitis, contact, including poison ivy, poison oak, or poison sumac; wounds, minor such as cuts and scratches.
- Epidural anesthesia can be performed in the sacral hiatus (caudal anesthesia) or in the lumbar, thoracic, or cervical regions of the spine.
- Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
- Hemorrhoids
- Pruritis of the skin
- Pruritus Ani
- Skin Irritation
How to use it
- The standard dose for this medicine is up to three times a day (eg after your morning bowel motion, noon and evening) or as your doctor or pharmacist tells you.
- Your doctor may have prescribed a different dose.
- Ask your doctor or pharmacist if you are unsure of the correct dose for you.
- They will tell you exactly how much to use. Follow the instructions they give you. If you use the wrong dose
- May not work as well and your problem may not improve.
How to use it
Ointment
- If the affected area is on the surface, use your finger to apply just enough ointment to cover the painful area.
- If you need to apply ointment deeper, first screw the plastic nozzle & cap (which are supplied in the carton) tightly on to the tube, removing the cap immediately before use.
- Then gently insert the nozzle all the way into the rectum (back passage) and squeeze the tube from the lower end, while at the same time withdrawing it from the rectum.
- After use, wash the nozzle with warm, soapy water then recap the nozzle.
Suppositories
- Remove the suppository from its packaging.
- Moisten the suppository by dipping it briefly in cool water.
- Put one foot on the side of the bath or toilet, raising the knee to the chest.
- Insert the suppository gently into the rectum (back passage).
- Try not to go to the toilet for at least one hour to allow the suppository time to work.
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References
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