Ixazomib Citrate – Uses, Dosage, Side Effects, Interaction

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 82 min read

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Article Summary

Ixazomib is an active metabolite of MLN9708, a second-generation, boron-containing peptide proteasome inhibitor (PI) or proteasome inhibitor with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of...

Key Takeaways

This article explains Mechanism of Action in simple medical language.
This article explains Indications in simple medical language.
This article explains Contraindications in simple medical language.
This article explains Dosage in simple medical language.

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Written byDr. Harun Ar Rashid, MD - Arthritis, Bones, Joints Pain, Trauma, and Internal Medicine Specialist

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Definition

Ixazomib is an active metabolite of MLN9708, a second-generation, boron-containing peptide proteasome inhibitor (PI) or proteasome inhibitor with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first-generation PIs, second-generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.

Ixazomib is a small-molecule proteasome inhibitor that is used in combination with other antineoplastic agents to treat refractory multiple myeloma. Ixazomib is associated with a low rate of serum enzyme elevations during treatment and with rare instances of clinically apparent, acute liver injury.

Ixazomib is a glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzene)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for the treatment of multiple myeloma. It has a role as an apoptosis inducer, an orphan drug, a proteasome inhibitor, a drug metabolite, and an antineoplastic agent. It is a member of benzamides, a dichlorobenzene, a glycine derivative and a member of boronic acids.

Ixazomib Citrate is the citrate salt form of ixazomib, an orally bioavailable second-generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first-generation PIs, second-generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.

Ixazomib citrate is a glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzene)glycine with the amino group of 2,2′-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid. A prodrug for ixazomib that is used in combination therapy for the treatment of multiple myeloma. It has a role as a prodrug, a proteasome inhibitor, an orphan drug, an antineoplastic agent, and an apoptosis inducer. It is a glycine derivative, a member of benzamides, a dichlorobenzene, an oxo dicarboxylic acid, and a 1,3,2-dioxaborolane. It is functionally related to an ixazomib.

Mechanism of Action

Ixazomib is an N-capped dipeptidyl leucine boronic acid that reversibly inhibits the CT-L proteolytic (β5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic β1 and β2 subunits and induce the accumulation of ubiquitinated proteins. In vitro studies have shown ixazomib to induce apoptosis in multiple myeloma cells sensitive or resistant to other conventional therapies. In mouse xenograft models, ixazomib induced tumor growth inhibition.

At therapeutic concentrations, ixazomib selectively and reversibly inhibits the protein proteasome subunit beta type-5 (PSMB5)^[rx] with a dissociation half-life of 18 minutes. This mechanism is the same as that of bortezomib, which has a much longer dissociation half-life of 110 minutes; the related drug carfilzomib, by contrast, blocks PSMB5 irreversibly. Proteasome subunits beta type-1 and type-2 are only inhibited at high concentrations reached in cell culture models.^[rx]

PSMB5 is part of the 20S proteasome complex and has an enzymatic activity similar to chymotrypsin. It induces apoptosis, a type of programmed cell death, in various cancer cell lines. A synergistic effect of ixazomib and lenalidomide has been found in a large number of myeloma cell lines. Ixazomib a second-generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy.

Indications

Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. It is used in combination with dexamethasone and lenalidomide in patients who have had one prior treatment, allowing patients to be on a fully oral regimen, which has been proven to have a progression-free survival benefit.[rx][rx]
Treatment of lymphoid malignancies (excluding multiple myeloma)
Ixazomib is a small-molecule proteasome inhibitor that is used in combination with other antineoplastic agents to treat refractory multiple myeloma
Treatment of systemic light chain amyloidosis.
Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.

Use in Cancer

Ixazomib citrate is approved to be used with lenalidomide and dexamethasone to treat:

Multiple myeloma in patients who have already received at least one other type of treatment.

Ixazomib citrate is also being studied in the treatment of other types of cancer.

Contraindications

decreased blood platelets
low levels of a type of white blood cell called neutrophils
a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
liver problems
fluid retention in the legs, feet, arms or hands
abnormal liver function tests
pregnancy
a patient who is producing milk and breastfeeding
chronic kidney disease stage 4 (severe)
chronic kidney disease stage 5 (failure)
kidney disease with likely reduction in kidney function
Child-Pugh class B liver impairment
Child-Pugh class C liver impairment

Dosage

Strengths: 2.3 mg; 3 mg; 4 mg

Multiple Myeloma

4 mg orally once a week on Days 1, 8, and 15 of a 28-day cycle
This drug is only given in combination with lenalidomide and dexamethasone.
For additional information regarding lenalidomide and dexamethasone, refer to their prescribing information.
Antiviral prophylaxis should be considered to decrease the risk of herpes zoster reactivation.
Prior to initiating a new cycle of therapy:
The absolute neutrophil count should be at least 1,000/mm3, the Platelet count should be at least 75,000/mm3, and Nonhematologic toxicities should, at physician discretion, generally be recovered to patient baseline condition or Grade 1 or lower
Treatment should be continued until the disease progresses or has unacceptable toxicity.
In combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy

Dose Adjustments

DOSE REDUCTIONS DUE TO ADVERSE REACTIONS:

Recommended starting dose: 4 mg
First reduction recommendation: 3 mg
Second reduction recommendation: 2.3 mg
Discontinue therapy

DOSE MODIFICATION GUIDELINES FOR THIS DRUG IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE:
THROMBOCYTOPENIA:
Platelet count less than 30,000/mm3:

Withhold this drug and lenalidomide until the platelet count is at least 30,000/mm3.
Following recovery, resume lenalidomide at the next lower dose according to its prescribing information and resume this drug at its most recent dose.
If the platelet count falls to less than 30,000/mm3 again, withhold this drug and lenalidomide until the platelet count is at least 30,000/mm3.
Following recovery, resume this drug at the next lower dose and resume lenalidomide at its most recent dose.

NEUTROPENIA:
Absolute neutrophil count less than 500/mm3:

Withhold this drug and lenalidomide until the absolute neutrophil count is at least 500/mm3. Consider adding granulocyte colony-stimulating factor (G-CSF) as per clinical guidelines.
Following recovery, resume lenalidomide at the next lower dose according to its prescribing information and resume this drug at its most recent dose.
If the absolute neutrophil count falls to less than 500/mm3 again, withhold this drug and lenalidomide until the absolute neutrophil count is at least 500/mm3.
Following recovery, resume this drug at the next lower dose and resume lenalidomide at its most recent dose.

NONHEMATOLOGIC TOXICITIES RECOMMENDED DOSE MODIFICATIONS:
Grade 2 or 3 rash:

Withhold lenalidomide until the rash recovers to Grade 1 or lower.
Following recovery, resume lenalidomide at the next lower dose according to its prescribing information.
If a Grade 2 or 3 rash occurs again, withhold this drug and lenalidomide until the rash recovers to Grade 1 or lower.
Following recovery, resume this drug at the next lower dose and resume lenalidomide at its most recent dose.

Grade 4 rash:

Discontinue therapy.

PERIPHERAL NEUROPATHY RECOMMENDED DOSE MODIFICATIONS:
Grade 1 peripheral neuropathy with pain or Grade 2 peripheral neuropathy:

Withhold this drug until peripheral neuropathy recovers to Grade 1 or lower without pain or the patient’s baseline.
Following recovery, resume this drug at its most recent dose.

Grade 2 peripheral neuropathy with pain or Grade 3 peripheral neuropathy:

Withhold this drug. Toxicities should, at the physician’s discretion, generally recover to the patient’s baseline condition or Grade 1 or lower prior to resuming this drug.
Following recovery, resume this drug at the next lower dose.

Grade 4 peripheral neuropathy:

Discontinue therapy.

OTHER NONHEMATOLOGIC TOXICITIES RECOMMENDED DOSE MODIFICATIONS:
Other Grade 3 or 4 nonhematological toxicities:

Withhold this drug. Toxicities should, at the physician’s discretion, generally recover to the patient’s baseline condition or Grade 1 or lower prior to resuming this drug.
If attributable to this drug, resume this drug at the next lower dose following recovery.

Patients take ixazomib by mouth; based on the drug approval study, it should be taken weekly on days 1, 8, and 15 of a 28-day cycle.[rx] The recommended dose is 4 mg, and for patients with moderate or severe hepatic impairment, renal impairment, or need dialysis, this dose is reduced to 3 mg. Ixazomib comes in three different capsule doses, which are 4 mg, 3 mg, and 2.3 mg.[rx]

It is also important to keep in mind that ixazomib should be given with dexamethasone and lenalidomide, which have their specific dosing schedules within a cycle. Both ixazomib and dexamethasone are given on days 1, 8, and 15; hence it is important to separate them since ixazomib should not be taken with food, whereas dexamethasone should be.[rx][rx]

Administration advice:

Capsules should not be opened or crushed.
This drug is cytotoxic and direct contact with the capsule contents should be avoided.
If contact occurs with the skin, wash thoroughly with soap and water.
If contact occurs with the eyes, flush thoroughly with water.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
The patient should be advised to read the approved patient labeling.
If a dose is delayed or missed, the dose should be taken only if the next scheduled dose is 72 hours away or more.
A missed dose should not be taken within 72 hours of the next scheduled dose.
A double dose should not be taken to make up for the missed dose.
If vomiting occurs after taking a dose, the patient should not repeat the dose. The patient should resume dosing at the time of the next scheduled dose.
Patients should be advised to take this drug exactly as prescribed.
Patients should be advised to take this drug at least 1 hour before or at least 2 hours after food.
Patients should be advised that this drug and dexamethasone should not be taken at the same time, because dexamethasone should be taken with food.
Patients should swallow the capsule whole with water. The capsule should not be crushed, chewed or opened.
Patients should be advised that direct contact with the capsule contents should be avoided.
Patients should be advised to wash thoroughly with soap and water If contact occurs with the skin and to flush thoroughly with water If contact occurs with the eyes.

Side Effects

The Most Common

diarrhea
constipation
nausea
new or worsening rash
back pain
unusual swelling of your arms or legs
weight gain due to swelling
blurred vision
dry eyes
pink eye
nausea
extreme tiredness
loss of appetite
flu-like symptoms
unusual bleeding or bruising
yellowing of your skin or eyes
pain in the upper right part of your stomach
burning, tingling, numbness, pain, or weakness in arms or legs
bloody or black, tarry stool

More common

Black, tarry stools
bloating or swelling of the face, arms, hands, lower legs, or feet
burning, numbness, tingling, or painful sensations
chills
cough
dark urine
diarrhea
dizziness
fever
headache
itching or rash
light-colored stools
loss of appetite
lower back or side pain
nausea
numbness, tingling, or pain in the hands or feet
painful or difficult urination
pale skin
rapid weight gain
rash with flat lesions or small raised lesions on the skin
redness or discoloration of the skin
sore throat
stomach pain
tingling of the hands or feet
ulcers, sores, or white spots in the mouth
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
vomiting of blood
weakness in the arms, hands, legs, or feet
yellow eyes or skin

Rare

Bleeding gums
blood in the urine or stools
pinpoint red spots on the skin
Blistering, peeling, or loosening of the skin
bloody nose
heavier menstrual periods
joint or muscle pain
red skin lesions, often with a purple center
red, irritated eyes
Back pain
blurred vision
body aches or pain
burning, dry, or itching eyes
difficulty having a bowel movement (stool)
discharge, excessive tearing
ear congestion
loss of voice
nasal congestion
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
sneezing

Drug Interaction

DRUG	INTERACTION
Abacavir	Abacavir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Abametapir	The serum concentration of Ixazomib can be increased when it is combined with Abametapir.
Abatacept	The metabolism of Ixazomib can be increased when combined with Abatacept.
Acalabrutinib	The metabolism of Ixazomib can be decreased when combined with Acalabrutinib.
Aceclofenac	Aceclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Acetaminophen	The metabolism of Ixazomib can be increased when combined with Acetaminophen.
Acetazolamide	The metabolism of Ixazomib can be decreased when combined with Acetazolamide.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Aclidinium	Aclidinium may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Acrivastine	Acrivastine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Adalimumab	The metabolism of Ixazomib can be increased when combined with Adalimumab.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Albendazole	The metabolism of Ixazomib can be decreased when combined with Albendazole.
Albutrepenona	Ixazomib may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac	Alclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Aldesleukin	The metabolism of Ixazomib can be decreased when combined with Aldesleukin.
Allopurinol	Allopurinol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Almasilate	Ixazomib may decrease the excretion rate of Almasilate which could result in a higher serum level.
Almotriptan	Almotriptan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Alogliptin	Alogliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Alpelisib	The metabolism of Ixazomib can be increased when combined with Alpelisib.
Alprazolam	Alprazolam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amantadine	Amantadine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amikacin	Ixazomib may decrease the excretion rate of Amikacin which could result in a higher serum level.
Amiloride	Amiloride may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Aminoglutethimide	The metabolism of Ixazomib can be increased when combined with Aminoglutethimide.
Aminophenazone	Aminophenazone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amiodarone	The metabolism of Ixazomib can be decreased when combined with Amiodarone.
Amitriptyline	Amitriptyline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ammonium chloride	Ammonium chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amobarbital	The metabolism of Ixazomib can be increased when combined with Amobarbital.
Amoxicillin	Amoxicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amphetamine	Amphetamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ampicillin	Ampicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Amprenavir	The metabolism of Ixazomib can be decreased when combined with Amprenavir.
Amrinone	Amrinone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Anakinra	The metabolism of Ixazomib can be increased when combined with Anakinra.
Ancestim	Ancestim may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Antihemophilic	Antihemophilic factor (recombinant), PEGylated may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Antipyrine	Antipyrine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Antithrombin III	Ixazomib may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
Antrafenine	Antrafenine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Apalutamide	The metabolism of Ixazomib can be increased when combined with Apalutamide.
Apremilast	The metabolism of Ixazomib can be increased when combined with Apremilast.
Aprepitant	The metabolism of Ixazomib can be decreased when combined with Aprepitant.
Arformoterol	Arformoterol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Armodafinil	The metabolism of Ixazomib can be increased when combined with Armodafinil.
Arsenic trioxide	Arsenic trioxide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Articaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Articaine.
Asciminib	The serum concentration of Ixazomib can be increased when it is combined with Asciminib.
Astemizole	The metabolism of Ixazomib can be decreased when combined with Astemizole.
Asunaprevir	The metabolism of Ixazomib can be increased when combined with Asunaprevir.
Atazanavir	The metabolism of Ixazomib can be decreased when combined with Atazanavir.
Atomoxetine	Atomoxetine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Auranofin	Auranofin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Aurothioglucose	Aurothioglucose may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Avacopan	The metabolism of Ixazomib can be decreased when combined with Avacopan.
Avanafil	The serum concentration of Avanafil can be increased when it is combined with Ixazomib.
Azacitidine	Azacitidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Azathioprine	Azathioprine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Azelaic acid	Azelaic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Azithromycin	The metabolism of Ixazomib can be decreased when combined with Azithromycin.
Aztreonam	Aztreonam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Bacitracin	Bacitracin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Baclofen	Baclofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Baricitinib	Ixazomib may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Beclomethasone d	The metabolism of Ixazomib can be increased when combined with Beclomethasone dipropionate.
Belzutifan	The serum concentration of Ixazomib can be decreased when it is combined with Belzutifan.
Bendroflumethi	Bendroflumethiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Benorilate	Benorilate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Benserazide	Ixazomib may decrease the excretion rate of Benserazide which could result in a higher serum level.
Benzatropine	Benzatropine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Benznidazole	Ixazomib may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Benzocaine.
Benzthiazide	Benzthiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Benzydamine	Benzydamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Benzyl alcohol.
Bepotastine	Bepotastine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Berotralstat	The serum concentration of Ixazomib can be increased when it is combined with Berotralstat.
Betamethasone	The metabolism of Ixazomib can be increased when combined with Betamethasone.
Betamethasone	The metabolism of Ixazomib can be increased when combined with Betamethasone phosphate.
Bexarotene	The metabolism of Ixazomib can be increased when combined with Bexarotene.
Bicalutamide	The metabolism of Ixazomib can be decreased when combined with Bicalutamide.
Bicisate	Ixazomib may decrease the excretion rate of Bicisate which could result in a higher serum level.
Bifonazole	The metabolism of Ixazomib can be decreased when combined with Bifonazole.
Bimekizumab	The metabolism of Ixazomib can be increased when combined with Bimekizumab.
Bismuth sub	Ixazomib may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
Bisoprolol	Bisoprolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Bisoxatin	Bisoxatin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Bleomycin	Bleomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Boceprevir	The metabolism of Ixazomib can be decreased when combined with Boceprevir.
Bosentan	The metabolism of Ixazomib can be increased when combined with Bosentan.
Bosutinib	The metabolism of Ixazomib can be decreased when combined with Bosutinib.
Brentuximab ve	The metabolism of Ixazomib can be decreased when combined with Brentuximab vedotin.
Brivaracetam	Brivaracetam may decrease the excretion rate of Ixazomib which could result in a higher serum level.

Bromazepam	Bromazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Bromotheophy	Bromotheophylline may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Budesonide	The metabolism of Ixazomib can be increased when combined with Budesonide.
Bumadizone	Bumadizone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Bumetanide	Bumetanide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Bupivacaine.
Buprenorphine	The metabolism of Ixazomib can be decreased when combined with Buprenorphine.
Bupropion	Bupropion may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Buspirone	Buspirone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Butabarbital	Butabarbital may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Butacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Butacaine.
Butalbital	The metabolism of Ixazomib can be increased when combined with Butalbital.
Butamben	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Butamben.
Calcitriol	The metabolism of Ixazomib can be increased when combined with Calcitriol.
Canagliflozin	Canagliflozin may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Canakinumab	The metabolism of Ixazomib can be increased when combined with Canakinumab.
Candicidin	The metabolism of Ixazomib can be decreased when combined with Candicidin.
Cannabidiol	The metabolism of Ixazomib can be decreased when combined with Cannabidiol.
Canrenoic acid	Canrenoic acid may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Capecitabine	Capecitabine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Capreomycin	Ixazomib may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Capsaicin.
Carbamazepine	The metabolism of Ixazomib can be increased when combined with Carbamazepine.
Carbidopa	Carbidopa may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Carboplatin	Carboplatin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Carmustine	Carmustine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Carprofen	Carprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefaclor	Cefaclor may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefdinir	Cefdinir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefepime	Cefepime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefoperazone	Cefoperazone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefpirome	Cefpirome may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefradine	The metabolism of Ixazomib can be increased when combined with Cefradine.
Ceftaroline fosamil	Ceftaroline fosamil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceftolozane	Ceftolozane may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceftriaxone	Ceftriaxone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Celecoxib	Celecoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cenobamate	The serum concentration of Ixazomib can be decreased when it is combined with Cenobamate.
Cephalexin	The metabolism of Ixazomib can be decreased when combined with Cephalexin.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ceritinib	The metabolism of Ixazomib can be decreased when combined with Ceritinib.
Cerivastatin	The metabolism of Ixazomib can be increased when combined with Cerivastatin.
Certolizumab pegol	The metabolism of Ixazomib can be increased when combined with Certolizumab pegol.
Cetirizine	Cetirizine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cevimeline	Cevimeline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Chloral hydrate	Chloral hydrate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Chloramphenicol	The metabolism of Ixazomib can be decreased when combined with Chloramphenicol.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Chloroprocaine.
Chloroquine	Chloroquine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Chlorothiazide	Chlorothiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Chloroxylenol	Ixazomib may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
Chlorpromazine	The metabolism of Ixazomib can be increased when combined with Chlorpromazine.
Chlorpropamide	Chlorpropamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Chlorthalidone	Chlorthalidone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Chlorzoxazone	Chlorzoxazone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Choline C 11	Choline C 11 may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Choline magnesium	Choline magnesium trisalicylate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Choline salicylate	Ixazomib may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
Chondroitin sulfate	Chondroitin sulfate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Chromic chloride	Chromic chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Chromic nitrate	Ixazomib may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
Chromium	Ixazomib may decrease the excretion rate of Chromium which could result in a higher serum level.
Chromium gluco	Ixazomib may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
Chromium nicotin	Ixazomib may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
Chromous sulfate	Ixazomib may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
Cidofovir	Cidofovir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cilostazol	Cilostazol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cimetidine	The metabolism of Ixazomib can be decreased when combined with Cimetidine.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Cinchocaine.
Ciprofloxacin	The metabolism of Ixazomib can be decreased when combined with Ciprofloxacin.
Cisapride	The metabolism of Ixazomib can be decreased when combined with Cisapride.
Cisplatin	Ixazomib may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Citalopram	The metabolism of Ixazomib can be decreased when combined with Citalopram.
Clarithromycin	The metabolism of Ixazomib can be decreased when combined with Clarithromycin.
Clevidipine	The metabolism of Ixazomib can be increased when combined with Clevidipine.
Clobazam	The metabolism of Ixazomib can be increased when combined with Clobazam.
Clobetasol propio	The metabolism of Ixazomib can be increased when combined with Clobetasol propionate.
Clofarabine	Clofarabine may decre

Clofazimine	The metabolism of Ixazomib can be decreased when combined with Clofazimine.
Clofibrate	The metabolism of Ixazomib can be increased when combined with Clofibrate.
Clomipramine	Clomipramine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Clonazepam	Clonazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Clorazepic acid	Clorazepic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Clove oil	Ixazomib may decrease the excretion rate of Clove oil which could result in a higher serum level.
Clozapine	The metabolism of Ixazomib can be increased when combined with Clozapine.
Cobicistat	The metabolism of Ixazomib can be decreased when combined with Cobicistat.
Cobimetinib	The metabolism of Ixazomib can be decreased when combined with Cobimetinib.
Cocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Cocaine.
Colchicine	Colchicine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Colistimethate	Colistimethate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Colistin	Ixazomib may decrease the excretion rate of Colistin which could result in a higher serum level.
Conivaptan	The metabolism of Ixazomib can be decreased when combined with Conivaptan.
Conjugated	Conjugated estrogens may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Corifollitropin alfa	Corifollitropin alfa may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Corticotropin	The metabolism of Ixazomib can be increased when combined with Corticotropin.
Cortisone acetate	The metabolism of Ixazomib can be increased when combined with Cortisone acetate.
Crizotinib	The metabolism of Ixazomib can be decreased when combined with Crizotinib.
Curcumin	The metabolism of Ixazomib can be decreased when combined with Curcumin.
Cyanocobalamin	Cyanocobalamin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Cyclopenthiazide	Cyclopenthiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Cyclophosphamide	The metabolism of Ixazomib can be increased when combined with Cyclophosphamide.
Cyclosporine	The metabolism of Ixazomib can be decreased when combined with Cyclosporine.
Cyclothiazide	Cyclothiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Cyproterone acetate	The metabolism of Ixazomib can be decreased when combined with Cyproterone acetate.
Dabigatran etexilate	Dabigatran etexilate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dabrafenib	The serum concentration of Ixazomib can be decreased when it is combined with Dabrafenib.
Dacarbazine	Dacarbazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dacomitinib	The metabolism of Ixazomib can be decreased when combined with Dacomitinib.
Dalfampridine	Dalfampridine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dalfopristin	The metabolism of Ixazomib can be decreased when combined with Dalfopristin.
Danazol	The metabolism of Ixazomib can be decreased when combined with Danazol.
Dapagliflozin	Dapagliflozin may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Daptomycin	Daptomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Darbepoetin alfa	The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Ixazomib.
Darunavir	The serum concentration of Ixazomib can be increased when it is combined with Darunavir.
Dasatinib	The metabolism of Ixazomib can be decreased when combined with Dasatinib.
Daunorubicin	The metabolism of Ixazomib can be decreased when combined with Daunorubicin.
Deferasirox	The metabolism of Ixazomib can be increased when combined with Deferasirox.
Deferiprone	Deferiprone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Deflazacort	The metabolism of Ixazomib can be increased when combined with Deflazacort.
Delafloxacin	Ixazomib may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Delavirdine	The metabolism of Ixazomib can be decreased when combined with Delavirdine.
Desipramine	The metabolism of Ixazomib can be decreased when combined with Desipramine.
Desmopressin	Desmopressin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Desvenlafaxine	The metabolism of Ixazomib can be decreased when combined with Desvenlafaxine.
Deutetrabenazine	Ixazomib may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Dexamethasone	The metabolism of Ixazomib can be increased when combined with Dexamethasone.
Dexamethasone	The metabolism of Ixazomib can be increased when combined with Dexamethasone acetate.
Dexibuprofen	Dexibuprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dexketoprofen	Dexketoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dexmedetomidine	Dexmedetomidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dexpanthenol	Dexpanthenol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dexrazoxane	Dexrazoxane may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dextran	Dextran may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dextropropox	The metabolism of Ixazomib can be decreased when combined with Dextropropoxyphene.
Diatrizoate	Diatrizoate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Diazepam	Diazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dichlorobenzyl a	Ixazomib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Diclofenac	Diclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Diclofenamide	Diclofenamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Dicloxacillin	The metabolism of Ixazomib can be increased when combined with Dicloxacillin.
Dicyclomine	Dicyclomine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Didanosine	Didanosine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dienogest	Dienogest may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Diethylstilbestrol	The metabolism of Ixazomib can be decreased when combined with Diethylstilbestrol.
Diflunisal	Diflunisal may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Difluocortolone	The metabolism of Ixazomib can be increased when combined with Difluocortolone.
Digoxin	Ixazomib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Dihydroergocornine	The metabolism of Ixazomib can be decreased when combined with Dihydroergocornine.
Dihydroergocristine	The metabolism of Ixazomib can be decreased when combined with Dihydroergocristine.
Dihydroergotamine	The metabolism of Ixazomib can be decreased when combined with Dihydroergotamine.
Dihydrostreptomycin	Dihydrostreptomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Diltiazem	The metabolism of Ixazomib can be decreased when combined with Diltiazem.
Dimercaprol	Dimercaprol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dimethyl sulfoxide	The metabolism of Ixazomib can be decreased when combined with Dimethyl sulfoxide.
Diosmin	The metabolism of Ixazomib can be decreased when combined with Diosmin.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Diphenhydramine.
Disopyramide	Disopyramide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
DL-Methylephedrine	Ixazomib may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
Dobutamine	Dobutamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Docetaxel	The metabolism of Ixazomib can be decreased when combined with Docetaxel.
Dopamine	Dopamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Doripenem	Doripenem may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Doxacurium	Doxacurium may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Doxazosin	The metabolism of Ixazomib can be decreased when combined with Doxazosin.
Doxepin	Doxepin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Doxorubicin	The metabolism of Ixazomib can be decreased when combined with Doxorubicin.
Doxycycline	Doxycycline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Dronedarone	The serum concentration of Ixazomib can be increased when it is combined with Dronedarone.
Drospirenone	The metabolism of Ixazomib can be decreased when combined with Drospirenone.
Droxidopa	Droxidopa may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Duloxetine	Duloxetine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Duvelisib	The metabolism of Ixazomib can be decreased when combined with Duvelisib.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Dyclonine.
Dyphylline	Dyphylline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ebastine	The metabolism of Ixazomib can be decreased when combined with Ebastine.
Echinacea	The metabolism of Ixazomib can be increased when combined with Echinacea.
Edoxaban	Edoxaban may decrease the excretion rate of Ixazomib which could result in a higher serum level.

Edrophonium	Edrophonium may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Efavirenz	The metabolism of Ixazomib can be decreased when combined with Efavirenz.
Elexacaftor	The metabolism of Ixazomib can be decreased when combined with Elexacaftor.
Elvitegravir	The metabolism of Ixazomib can be decreased when combined with Elvitegravir.
Emapalumab	The metabolism of Ixazomib can be increased when combined with Emapalumab.
Enalaprilat	Enalaprilat may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Enasidenib	The metabolism of Ixazomib can be increased when combined with Enasidenib.
Enzalutamide	The serum concentration of Ixazomib can be decreased when it is combined with Enzalutamide.
Epinephrine	The metabolism of Ixazomib can be decreased when combined with Epinephrine.
Eplerenone	Eplerenone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Epoprostenol	Epoprostenol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ergotamine	The metabolism of Ixazomib can be decreased when combined with Ergotamine.
Erlotinib	The metabolism of Ixazomib can be decreased when combined with Erlotinib.
Ertapenem	Ertapenem may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ertugliflozin	Ertugliflozin may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Erythromycin	The metabolism of Ixazomib can be decreased when combined with Erythromycin.
Erythropoietin	The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Ixazomib.
Esketamine	The metabolism of Ixazomib can be increased when combined with Esketamine.
Eslicarbazepine	The metabolism of Ixazomib can be increased when combined with Eslicarbazepine.
Eslicarbazepine	The metabolism of Ixazomib can be increased when combined with Eslicarbazepine acetate.
Estazolam	Estazolam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Estetrol	The metabolism of Ixazomib can be decreased when combined with Estetrol.
Estradiol	Estradiol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Estradiol acetate	The metabolism of Ixazomib can be increased when combined with Estradiol acetate.
Estradiol benzoate	The metabolism of Ixazomib can be increased when combined with Estradiol benzoate.
Estradiol cypionate	The metabolism of Ixazomib can be increased when combined with Estradiol cypionate.
Estradiol dienanthate	The metabolism of Ixazomib can be increased when combined with Estradiol dienanthate.
Estradiol valerate	The metabolism of Ixazomib can be increased when combined with Estradiol valerate.
Estrone sulfate	Estrone sulfate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Eszopiclone	Eszopiclone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Etacrynic acid	Etacrynic acid may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Etafedrine	Ixazomib may decrease the excretion rate of Etafedrine which could result in a higher serum level.
Etanercept	The metabolism of Ixazomib can be increased when combined with Etanercept.
Ethambutol	The metabolism of Ixazomib can be decreased when combined with Ethambutol.
Ethanol	The metabolism of Ixazomib can be increased when combined with Ethanol.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Ethyl chloride.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Etidocaine.
Etodolac	Etodolac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Etomidate	Etomidate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Etonogestrel	Etonogestrel may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Etoricoxib	The metabolism of Ixazomib can be decreased when combined with Etoricoxib.
Etravirine	The metabolism of Ixazomib can be increased when combined with Etravirine.
Eucalyptus oil	Ixazomib may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
Ezogabine	Ezogabine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Felbamate	The metabolism of Ixazomib can be increased when combined with Felbamate.
Fenbufen	Fenbufen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fenofibrate	The metabolism of Ixazomib can be decreased when combined with Fenofibrate.
Fenofibric acid	Ixazomib may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
Fenoldopam	Fenoldopam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fentanyl	Fentanyl may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fesoterodine	Fesoterodine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fexinidazole	The metabolism of Ixazomib can be decreased when combined with Fexinidazole.
Finerenone	Finerenone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Flavoxate	Flavoxate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Floctafenine	Floctafenine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Florbetaben (18F)	Florbetaben (18F) may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Florbetapir (18F)	Florbetapir (18F) may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Floxuridine	Floxuridine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Flucloxacillin	The metabolism of Ixazomib can be increased when combined with Flucloxacillin.
Fluconazole	The metabolism of Ixazomib can be decreased when combined with Fluconazole.
Flucytosine	Flucytosine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fludeoxyglucose	Fludeoxyglucose (18F) may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Flumazenil	Flumazenil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Flunisolide	The metabolism of Ixazomib can be increased when combined with Flunisolide.
Fluocinolone a	The metabolism of Ixazomib can be increased when combined with Fluocinolone acetonide.
Fluocinonide	The metabolism of Ixazomib can be increased when combined with Fluocinonide.
Fluocortolone	The metabolism of Ixazomib can be increased when combined with Fluocortolone.
Fluoxetine	The metabolism of Ixazomib can be decreased when combined with Fluoxetine.
Flurazepam	Flurazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Flutamide	Flutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fluticasone	The metabolism of Ixazomib can be increased when combined with Fluticasone.
Fluticasone p	The metabolism of Ixazomib can be decreased when combined with Fluticasone propionate.
Fluvoxamine	The metabolism of Ixazomib can be decreased when combined with Fluvoxamine.
Folic acid	Folic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fomepizole	Fomepizole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fondaparinux	Fondaparinux may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Formestane	The metabolism of Ixazomib can be increased when combined with Formestane.
Fosamprenavir	The metabolism of Ixazomib can be decreased when combined with Fosamprenavir.
Fosaprepitant	The metabolism of Ixazomib can be increased when combined with Fosaprepitant.
Foscarnet	Foscarnet may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fosfomycin	Fosfomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fosinopril	Fosinopril may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Fosnetupitant	The metabolism of Ixazomib can be decreased when combined with Fosnetupitant.
Fosphenytoin	The metabolism of Ixazomib can be increased when combined with Fosphenytoin.
Fostamatinib	The metabolism of Ixazomib can be decreased when combined with Fostamatinib.
Framycetin	Framycetin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Furosemide	Furosemide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Fusidic acid	The metabolism of Ixazomib can be decreased when combined with Fusidic acid.
Gabapentin enac	Gabapentin enacarbil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gadobenic acid	Gadobenic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gadodiamide	Gadodiamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gadofosveset trisodium	Gadofosveset trisodium may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gadopentetic acid	Gadopentetic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gadoteric acid	Gadoteric acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gadoteridol	Gadoteridol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ganciclovir	Ganciclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gemcitabine	Gemcitabine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Gemfibrozil	Gemfibrozil may decrease the excretion rate of Ixazomib which could result in a higher serum level.

Gentamicin	Ixazomib may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gilteritinib	The metabolism of Ixazomib can be decreased when combined with Gilteritinib.
Gimeracil	Gimeracil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ginkgo biloba	The metabolism of Ixazomib can be decreased when combined with Ginkgo biloba.
Givosiran	Givosiran may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Glecaprevir	The metabolism of Ixazomib can be decreased when combined with Glecaprevir.
Glipizide	Glipizide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Glyburide	The metabolism of Ixazomib can be decreased when combined with Glyburide.
Glycerol phenyl	The metabolism of Ixazomib can be increased when combined with Glycerol phenylbutyrate.
Golimumab	The metabolism of Ixazomib can be increased when combined with Golimumab.
Golodirsen	Ixazomib may decrease the excretion rate of Golodirsen which could result in a higher serum level.
Goserelin	Goserelin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Griseofulvin	The metabolism of Ixazomib can be increased when combined with Griseofulvin.
Guanethidine	Guanethidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Guanfacine	Guanfacine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Ixazomib.
Hydralazine	The metabolism of Ixazomib can be decreased when combined with Hydralazine.
Hydrochlorothiazide	Hydrochlorothiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Hydrocortamate	The metabolism of Ixazomib can be increased when combined with Hydrocortamate.
Hydrocortisone	The metabolism of Ixazomib can be increased when combined with Hydrocortisone.
Hydrocortisone a	The metabolism of Ixazomib can be increased when combined with Hydrocortisone acetate.
Hydrocortisone	The metabolism of Ixazomib can be increased when combined with Hydrocortisone butyrate.
Hydrocortisone	The metabolism of Ixazomib can be increased when combined with Hydrocortisone succinate.
Hydroflumethiazide	Hydroflumethiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Hydromorphone	Hydromorphone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Hydroxocobalamin	Hydroxocobalamin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Hydroxyethyl Starch	Hydroxyethyl Starch may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ibuprofen	Ibuprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ibutilide	Ibutilide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Icatibant	Icatibant may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Icosapent	Icosapent may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Idarucizumab	Idarucizumab may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Idebenone	Idebenone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Idelalisib	The metabolism of Ixazomib can be decreased when combined with Idelalisib.
Ifosfamide	The metabolism of Ixazomib can be increased when combined with Ifosfamide.
Imatinib	The serum concentration of Ixazomib can be increased when it is combined with Imatinib.
Imipramine	Imipramine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Indapamide	Indapamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Indigotindisulfonic	Ixazomib may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
Indinavir	The metabolism of Ixazomib can be decreased when combined with Indinavir.
Indomethacin	Indomethacin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Infigratinib	The metabolism of Ixazomib can be decreased when combined with Infigratinib.
Infliximab	The metabolism of Ixazomib can be increased when combined with Infliximab.
Inosine pranobex	Ixazomib may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
Inositol	Ixazomib may decrease the excretion rate of Inositol which could result in a higher serum level.
Inotersen	Inotersen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Iobenguane sulfa	Iobenguane sulfate I-123 may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Iodixanol	Iodixanol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ioflupane I-123	Ioflupane I-123 may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Iopromide	Iopromide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Iothalamic acid	Iothalamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ioversol	Ioversol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ioxilan	Ioxilan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ipecac	Ixazomib may decrease the excretion rate of Ipecac which could result in a higher serum level.
Ipilimumab	Ipilimumab may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Irbesartan	The metabolism of Ixazomib can be decreased when combined with Irbesartan.
Isavuconazole	The metabolism of Ixazomib can be increased when combined with Isavuconazole.
Isavuconazonium	The metabolism of Ixazomib can be increased when combined with Isavuconazonium.
Isoniazid	The metabolism of Ixazomib can be decreased when combined with Isoniazid.
Isosorbide	Isosorbide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide mon	Isosorbide mononitrate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Isosulfan blue	Isosulfan blue may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Isotretinoin	Isotretinoin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Isoxicam	Isoxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Isradipine	The metabolism of Ixazomib can be decreased when combined with Isradipine.
Itraconazole	The metabolism of Ixazomib can be decreased when combined with Itraconazole.
Ivacaftor	The metabolism of Ixazomib can be decreased when combined with Ivacaftor.
Ivosidenib	The metabolism of Ixazomib can be increased when combined with Ivosidenib.
Kanamycin	Ixazomib may decrease the excretion rate of Kanamycin which could result in a higher serum level.
Ketamine	Ketamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ketazolam	The metabolism of Ixazomib can be decreased when combined with Ketazolam.
Ketoconazole	The metabolism of Ixazomib can be decreased when combined with Ketoconazole.
Ketoprofen	Ketoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ketorolac	Ketorolac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Labetalol	Labetalol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lacosamide	The metabolism of Ixazomib can be decreased when combined with Lacosamide.
Lamivudine	Lamivudine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lamotrigine	Lamotrigine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lanreotide	The metabolism of Ixazomib can be decreased when combined with Lanreotide.
Lapatinib	The metabolism of Ixazomib can be decreased when combined with Lapatinib.
Latamoxef	Latamoxef may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ledipasvir	Ledipasvir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lefamulin	The serum concentration of Ixazomib can be increased when it is combined with Lefamulin.
Lenalidomide	Lenalidomide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad	The metabolism of Ixazomib can be increased when combined with Lesinurad.
Letermovir	The metabolism of Ixazomib can be decreased when combined with Letermovir.
Leuprolide	Leuprolide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Levobupivacaine.
Levocarnitine	Levocarnitine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Levocetirizine	Levocetirizine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Levofloxacin	Levofloxacin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Levoketoconazole	The metabolism of Ixazomib can be decreased when combined with Levoketoconazole.
Levomilnacipran	Levomilnacipran may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Levosalbutamol	Ixazomib may decrease the excretion rate of Levosalbutamol which could result in a higher serum level.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Lidocaine.
Linagliptin	The metabolism of Ixazomib can be decreased when combined with Linagliptin.
Liothyronine	Liothyronine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lisinopril	Lisinopril may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lithium carbonate	Ixazomib may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate	Lithium citrate may decrease the excretion rate of Ixazomib which could result in a higher serum level.

Lixisenatide	Lixisenatide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lofexidine	Lofexidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lomitapide	The metabolism of Ixazomib can be decreased when combined with Lomitapide.
Lonafarnib	The metabolism of Ixazomib can be decreased when combined with Lonafarnib.
Lopinavir	The metabolism of Ixazomib can be decreased when combined with Lopinavir.
Loracarbef	Loracarbef may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lorazepam	Lorazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lorcaserin	Lorcaserin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lorlatinib	The metabolism of Ixazomib can be increased when combined with Lorlatinib.
Lornoxicam	Lornoxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lorpiprazole	Lorpiprazole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Losartan	The metabolism of Ixazomib can be decreased when combined with Losartan.
Lovastatin	The metabolism of Ixazomib can be decreased when combined with Lovastatin.
Loxoprofen	Loxoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lubiprostone	Lubiprostone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lumacaftor	The metabolism of Ixazomib can be increased when combined with Lumacaftor.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Macitentan	Macitentan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Magnesium carbo	Magnesium carbonate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Magnesium chloride	Magnesium chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Magnesium hyd	Magnesium hydroxide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Magnesium tris	Magnesium trisilicate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Mangafodipir	Mangafodipir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Manidipine	The metabolism of Ixazomib can be decreased when combined with Manidipine.
Mannitol	Mannitol may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline	Maprotiline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Mavacamten	The serum concentration of Ixazomib can be decreased when it is combined with Mavacamten.
Mecamylamine	Mecamylamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Medroxyprogester	The metabolism of Ixazomib can be increased when combined with Medroxyprogesterone acetate.
Mefenamic acid	Mefenamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Megestrol acetate	Megestrol acetate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Meloxicam.
Memantine	Memantine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Meperidine	The metabolism of Ixazomib can be decreased when combined with Meperidine.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Mepivacaine.
Meprednisone	The metabolism of Ixazomib can be increased when combined with Meprednisone.
Meropenem	Meropenem may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Metamfetamine	Metamfetamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Metamizole	Metamizole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Metaxalone	Metaxalone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Metformin	Metformin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Methadone	The metabolism of Ixazomib can be decreased when combined with Methadone.
Methazolamide	Methazolamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	The metabolism of Ixazomib can be decreased when combined with Methimazole.
Methotrexate	Methotrexate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Methoxsalen	Methoxsalen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Methoxy	The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Ixazomib.
Methyldopa	Methyldopa may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Methylene blue	The metabolism of Ixazomib can be decreased when combined with Methylene blue.
Methylergometrine	The metabolism of Ixazomib can be decreased when combined with Methylergometrine.
Methylnaltrexone	Methylnaltrexone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Methylphenobarbital	The metabolism of Ixazomib can be increased when combined with Methylphenobarbital.
Methylprednisolone	The metabolism of Ixazomib can be increased when combined with Methylprednisolone.
Methylprednisone	The metabolism of Ixazomib can be decreased when combined with Methylprednisone.
Methyltestosterone	Methyltestosterone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Methysergide	The metabolism of Ixazomib can be decreased when combined with Methysergide.
Meticrane	Meticrane may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Metoclopramide	Metoclopramide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Metolazone	Metolazone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Metoprolol	Metoprolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Metreleptin	The metabolism of Ixazomib can be increased when combined with Metreleptin.
Metronidazole	The metabolism of Ixazomib can be decreased when combined with Metronidazole.
Metyrapone	The metabolism of Ixazomib can be increased when combined with Metyrapone.
Miconazole	The metabolism of Ixazomib can be decreased when combined with Miconazole.
Midazolam	The metabolism of Ixazomib can be decreased when combined with Midazolam.
Midostaurin	The metabolism of Ixazomib can be decreased when combined with Midostaurin.
Mifepristone	The metabolism of Ixazomib can be increased when combined with Mifepristone.
Migalastat	Migalastat may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Milnacipran	The metabolism of Ixazomib can be decreased when combined with Milnacipran.
Milrinone	Milrinone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Miocamycin	The metabolism of Ixazomib can be decreased when combined with Miocamycin.
Mirabegron	Mirabegron may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Mirtazapine	The metabolism of Ixazomib can be decreased when combined with Mirtazapine.
Mitapivat	The metabolism of Ixazomib can be increased when combined with Mitapivat.
Mitotane	The metabolism of Ixazomib can be increased when combined with Mitotane.
Mobocertinib	The serum concentration of Ixazomib can be decreased when it is combined with Mobocertinib.
Modafinil	The metabolism of Ixazomib can be increased when combined with Modafinil.
Mometasone fur	The metabolism of Ixazomib can be increased when combined with Mometasone furoate.
Mosunetuzumab	The metabolism of Ixazomib can be decreased when combined with Mosunetuzumab.
Moxisylyte	Moxisylyte may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Muzolimine	Muzolimine may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Mycophenolate	Mycophenolate mofetil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Mycophenolic acid	Mycophenolic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
N-acetyltyrosine	Ixazomib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Nabumetone	Nabumetone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nadolol	Nadolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nafcillin	The metabolism of Ixazomib can be increased when combined with Nafcillin.
Naldemedine	Ixazomib may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Nalmefene	Nalmefene may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Naloxone	Naloxone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Naproxen	Naproxen may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nateglinide	Nateglinide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nedaplatin	Ixazomib may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Nedocromil	Nedocromil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nefazodone	The metabolism of Ixazomib can be decreased when combined with Nefazodone.
Nelfinavir	The metabolism of Ixazomib can be decreased when combined with Nelfinavir.
Neomycin	Ixazomib may decrease the excretion rate of Neomycin which could result in a higher serum level.
Netilmicin	Ixazomib may decrease the excretion rate of Netilmicin which could result in a higher serum level.

Netupitant	The metabolism of Ixazomib can be decreased when combined with Netupitant.
Niacin	The metabolism of Ixazomib can be decreased when combined with Niacin.
Nicardipine	The metabolism of Ixazomib can be decreased when combined with Nicardipine.
Nicorandil	Nicorandil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nifedipine	Nifedipine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nilotinib	The metabolism of Ixazomib can be decreased when combined with Nilotinib.
Nilutamide	Nilutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nilvadipine	The metabolism of Ixazomib can be decreased when combined with Nilvadipine.
Nimesulide	Nimesulide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nintedanib	The metabolism of Ixazomib can be decreased when combined with Nintedanib.
Nisoldipine	Nisoldipine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nitric Oxide	Nitric Oxide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nitrofurantoin	Nitrofurantoin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Nitroprusside	Nitroprusside may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Norethisterone	The metabolism of Ixazomib can be decreased when combined with Norethisterone.
Norgestimate	The metabolism of Ixazomib can be increased when combined with Norgestimate.
Noscapine	The metabolism of Ixazomib can be decreased when combined with Noscapine.
Octinoxate	Octinoxate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Octreotide	The serum concentration of Ixazomib can be increased when it is combined with Octreotide.
Olaparib	The metabolism of Ixazomib can be decreased when combined with Olaparib.
Olsalazine	Olsalazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Opium	Ixazomib may decrease the excretion rate of Opium which could result in a higher serum level.
Oritavancin	The metabolism of Ixazomib can be increased when combined with Oritavancin.
Orphenadrine	The metabolism of Ixazomib can be decreased when combined with Orphenadrine.
Oseltamivir	Oseltamivir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Osilodrostat	The metabolism of Ixazomib can be decreased when combined with Osilodrostat.
Osimertinib	The metabolism of Ixazomib can be decreased when combined with Osimertinib.
Oxacillin	Oxacillin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Oxaprozin	Oxaprozin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Oxazepam	Oxazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Oxcarbazepine	The metabolism of Ixazomib can be increased when combined with Oxcarbazepine.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Oxetacaine.
Oxybenzone	Oxybenzone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Oxybuprocaine.
Oxybutynin	The metabolism of Ixazomib can be decreased when combined with Oxybutynin.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Oxyquinoline	Ixazomib may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
Paclitaxel	The metabolism of Ixazomib can be increased when combined with Paclitaxel.
Pacritinib	The serum concentration of Ixazomib can be increased when it is combined with Pacritinib.
Palbociclib	The metabolism of Ixazomib can be decreased when combined with Palbociclib.
Paliperidone	Paliperidone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Palonosetron	Palonosetron may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pantoprazole	Pantoprazole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Parecoxib	Parecoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Paromomycin	Paromomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pasireotide	The metabolism of Ixazomib can be decreased when combined with Pasireotide.
Patent Blue	Ixazomib may decrease the excretion rate of Patent Blue which could result in a higher serum level.
Pazopanib	The metabolism of Ixazomib can be decreased when combined with Pazopanib.
Pegaptanib	Pegaptanib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Peginesatide	The risk or severity of Thrombosis can be increased when Peginesatide is combined with Ixazomib.
Pemetrexed	Ixazomib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Penbutolol	Penbutolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pentaerythritol t	Pentaerythritol tetranitrate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pentamidine	Pentamidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pentastarch	Pentastarch may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pentetic acid	Ixazomib may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Pentobarbital	The metabolism of Ixazomib can be increased when combined with Pentobarbital.
Pentostatin	Ixazomib may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Perampanel	The metabolism of Ixazomib can be increased when combined with Perampanel.
Perindopril	Perindopril may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Permethrin	Permethrin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Phenazopyridine	Phenazopyridine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Phenelzine	Phenelzine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Phenobarbital	The metabolism of Ixazomib can be increased when combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Phenol.
Phentolamine	Phentolamine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Phenylbutazone	The metabolism of Ixazomib can be increased when combined with Phenylbutazone.
Phenytoin	The metabolism of Ixazomib can be increased when combined with Phenytoin.
Pholcodine	Pholcodine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Phosphoric acid	Phosphoric acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Phylloquinone	Phylloquinone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Picosulfuric acid	Picosulfuric acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pimavanserin	The metabolism of Ixazomib can be decreased when combined with Pimavanserin.
Pimozide	The metabolism of Ixazomib can be decreased when combined with Pimozide.
Pindolol	Pindolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Piperacillin	Piperacillin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Piperaquine	The metabolism of Ixazomib can be decreased when combined with Piperaquine.
Piracetam	Piracetam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Piretanide	Piretanide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Piroxicam	Piroxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pitolisant	The serum concentration of Ixazomib can be decreased when it is combined with Pitolisant.
Plazomicin	Ixazomib may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Plerixafor	Plerixafor may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Polythiazide	Polythiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Pomalidomide	Pomalidomide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Posaconazole	The metabolism of Ixazomib can be decreased when combined with Posaconazole.
Potassium	Potassium may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Potassium acetate	Ixazomib may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
Potassium bic	Ixazomib may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
Potassium cation	Potassium cation may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Potassium chloride	Potassium chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Potassium citrate	Potassium citrate may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Potassium nitrate	Ixazomib may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
Potassium per	Potassium perchlorate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Potassium sulfate	Ixazomib may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
Pralatrexate	Pralatrexate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pralidoxime	Pralidoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pralsetinib	The metabolism of Ixazomib can be increased when combined with Pralsetinib

Pramipexole	Pramipexole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Pramocaine.
Prasugrel	Prasugrel may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Prednisolone	The metabolism of Ixazomib can be increased when combined with Prednisolone.
Prednisolone ac	The metabolism of Ixazomib can be increased when combined with Prednisolone acetate.
Prednisolone	The metabolism of Ixazomib can be increased when combined with Prednisolone phosphate.
Prednisone	Prednisone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Prednisone acet	The metabolism of Ixazomib can be increased when combined with Prednisone acetate.
Pregabalin	Pregabalin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pretomanid	The metabolism of Ixazomib can be decreased when combined with Pretomanid.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Prilocaine.
Primaquine	The metabolism of Ixazomib can be decreased when combined with Primaquine.
Primidone	The metabolism of Ixazomib can be increased when combined with Primidone.
Probenecid	The metabolism of Ixazomib can be increased when combined with Probenecid.
Procainamide	Ixazomib may decrease the excretion rate of Procainamide which could result in a higher serum level.
Procaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Procaine.
Procaine benz	Procaine benzylpenicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Promethazine	Promethazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Propantheline	Propantheline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Proparacaine.
Propiverine	Ixazomib may decrease the excretion rate of Propiverine which could result in a higher serum level.
Propofol	The metabolism of Ixazomib can be decreased when combined with Propofol.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Propoxycaine.
Propranolol	Propranolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Prucalopride	Prucalopride may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pyrantel	Ixazomib may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Pyrazinamide	Pyrazinamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pyridoxine	Pyridoxine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Pyrithione	Pyrithione may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Quetiapine	Quetiapine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Quinethazone	Quinethazone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine	The metabolism of Ixazomib can be decreased when combined with Quinidine.
Quinine	The metabolism of Ixazomib can be increased when combined with Quinine.
Quinupristin	The metabolism of Ixazomib can be decreased when combined with Quinupristin.
Rabeprazole	Rabeprazole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Raloxifene	The metabolism of Ixazomib can be decreased when combined with Raloxifene.
Ramelteon	Ramelteon may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ranitidine	Ranitidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ranolazine	The metabolism of Ixazomib can be decreased when combined with Ranolazine.
Rasagiline	Rasagiline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Remdesivir	The metabolism of Ixazomib can be decreased when combined with Remdesivir.
Reserpine	Reserpine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Resorcinol	Ixazomib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ribavirin	Ribavirin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ribociclib	The metabolism of Ixazomib can be decreased when combined with Ribociclib.
Ribostamycin	Ixazomib may decrease the excretion rate of Ribostamycin which could result in a higher serum level.
Rifabutin	The metabolism of Ixazomib can be increased when combined with Rifabutin.
Rifampicin	The metabolism of Ixazomib can be increased when combined with Rifampicin.
Rifamycin	The metabolism of Ixazomib can be increased when combined with Rifamycin.
Rifapentine	The metabolism of Ixazomib can be increased when combined with Rifapentine.
Rilonacept	The metabolism of Ixazomib can be increased when combined with Rilonacept.
Rilpivirine	The metabolism of Ixazomib can be decreased when combined with Rilpivirine.
Ritonavir	The serum concentration of Ixazomib can be increased when it is combined with Ritonavir.
Rivaroxaban	Rivaroxaban may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rizatriptan	Rizatriptan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rofecoxib	The metabolism of Ixazomib can be increased when combined with Rofecoxib.
Roflumilast	The metabolism of Ixazomib can be decreased when combined with Roflumilast.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Ropivacaine.
Rosiglitazone	Rosiglitazone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rosuvastatin	The metabolism of Ixazomib can be decreased when combined with Rosuvastatin.
Roxithromycin	The metabolism of Ixazomib can be decreased when combined with Roxithromycin.
Rucaparib	The metabolism of Ixazomib can be decreased when combined with Rucaparib.
Rufinamide	The metabolism of Ixazomib can be increased when combined with Rufinamide.
Ruxolitinib	Ruxolitinib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sacubitril	Sacubitril may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Salbutamol	Salbutamol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Salicylamide	Salicylamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Salmon calcitonin	Salmon calcitonin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Saquinavir	The metabolism of Ixazomib can be decreased when combined with Saquinavir.
Sarilumab	The metabolism of Ixazomib can be increased when combined with Sarilumab.
Satralizumab	The serum concentration of Ixazomib can be decreased when it is combined with Satralizumab.
Saxagliptin	Saxagliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Secobarbital	The metabolism of Ixazomib can be increased when combined with Secobarbital.
Secukinumab	The metabolism of Ixazomib can be increased when combined with Secukinumab.
Selenious acid	Ixazomib may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Selenium	Ixazomib may decrease the excretion rate of Selenium which could result in a higher serum level.
Sibutramine	Sibutramine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Siltuximab	The metabolism of Ixazomib can be increased when combined with Siltuximab.
Simeprevir	The metabolism of Ixazomib can be decreased when combined with Simeprevir.
Siponimod	The metabolism of Ixazomib can be decreased when combined with Siponimod.
Sitagliptin	Sitagliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sitaxentan	The metabolism of Ixazomib can be decreased when combined with Sitaxentan.
Sodium acetate	Sodium acetate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sodium auroth	Sodium aurothiomalate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sodium fluoride	Sodium fluoride may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sodium sulfate	Sodium sulfate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sofosbuvir	Sofosbuvir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Solriamfetol	Ixazomib may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Somatostatin	The metabolism of Ixazomib can be decreased when combined with Somatostatin.
Somatrogon	The metabolism of Ixazomib can be increased when combined with Somatrogon.
Sorafenib	Sorafenib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sorbitol	Sorbitol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sotorasib	The serum concentration of Ixazomib can be decreased when it is combined with Sotorasib.
Spironolactone	Spironolactone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
St. John’s Wort	The metabolism of Ixazomib can be increased when combined with St. John’s Wort.
Stiripentol	The metabolism of Ixazomib can be decreased when combined with Stiripentol.
Streptomycin	Ixazomib may decrease the excretion rate of Streptomycin which could result in a higher serum level.
Strontium chloride	Ixazomib may decrease the excretion rate of Strontium chloride which could result in a higher serum level.

Sucralfate	Sucralfate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sulbactam	Sulbactam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sulfadiazine	Sulfadiazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sulfamethoxazole	The metabolism of Ixazomib can be decreased when combined with Sulfamethoxazole.
Sulfasalazine	Sulfasalazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sulfinpyrazone	The metabolism of Ixazomib can be increased when combined with Sulfinpyrazone.
Sulindac	Sulindac may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sumatriptan	Sumatriptan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Suvorexant	The metabolism of Ixazomib can be decreased when combined with Suvorexant.
Sy Estrogens, A	Synthetic Conjugated Estrogens, A may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Sy Estrogens, B	Synthetic Conjugated Estrogens, B may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tacrolimus	The metabolism of Ixazomib can be decreased when combined with Tacrolimus.
Tadalafil	Tadalafil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tamoxifen	The metabolism of Ixazomib can be increased when combined with Tamoxifen.
Tamsulosin	Tamsulosin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tasimelteon	The metabolism of Ixazomib can be decreased when combined with Tasimelteon.
Tazemetostat	The metabolism of Ixazomib can be decreased when combined with Tazemetostat.
Technetium Tc-99m	Technetium Tc-99m exametazime may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Technetium Tc	Technetium Tc-99m mebrofenin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Technetium	Technetium Tc-99m oxidronate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Technetium	Technetium Tc-99m pyrophosphate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tecovirimat	The metabolism of Ixazomib can be increased when combined with Tecovirimat.
Teduglutide	Teduglutide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tegafur	Tegafur may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Telaprevir	The metabolism of Ixazomib can be decreased when combined with Telaprevir.
Telavancin	Telavancin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Telithromycin	The metabolism of Ixazomib can be decreased when combined with Telithromycin.
Telotristat ethyl	The serum concentration of Ixazomib can be decreased when it is combined with Telotristat ethyl.
Temazepam	Temazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Temozolomide	Temozolomide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Teniposide	The metabolism of Ixazomib can be decreased when combined with Teniposide.
Tenofovir alafe	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Ixazomib.
Tenofovir diso	Tenofovir disoproxil may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tenoxicam	Tenoxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Terbinafine	The metabolism of Ixazomib can be increased when combined with Terbinafine.
Terbutaline	Terbutaline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Terfenadine	The metabolism of Ixazomib can be decreased when combined with Terfenadine.
Testolactone	Testolactone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Testosterone	The metabolism of Ixazomib can be increased when combined with Testosterone.
Testosterone	Ixazomib may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
Testosterone ena	Ixazomib may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
Testosterone prop	Testosterone propionate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Testosterone unde	Ixazomib may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Tetracaine.
Tetracycline	The metabolism of Ixazomib can be decreased when combined with Tetracycline.
Tetradecyl hydrog	Ixazomib may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
Thiabendazole	Thiabendazole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Thiamylal	The metabolism of Ixazomib can be increased when combined with Thiamylal.
Thiethylperazine	Thiethylperazine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Ticagrelor	The metabolism of Ixazomib can be decreased when combined with Ticagrelor.
Ticlopidine	Ticlopidine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tiludronic acid	Tiludronic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Timolol	Timolol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tinidazole	Tinidazole may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tiopronin	Tiopronin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tiotropium	Tiotropium may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tipranavir	The metabolism of Ixazomib can be decreased when combined with Tipranavir.
Tirofiban	Tirofiban may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tixocortol	Tixocortol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tobramycin	Ixazomib may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Tocilizumab	The metabolism of Ixazomib can be increased when combined with Tocilizumab.
Tocopherol	Ixazomib may decrease the excretion rate of Tocopherol which could result in a higher serum level.
Tolazamide	Tolazamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tolbutamide	Tolbutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tolcapone	Tolcapone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tolfenamic acid	Tolfenamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tolterodine	Tolterodine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tolvaptan	Tolvaptan may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Topiramate	The metabolism of Ixazomib can be increased when combined with Topiramate.
Topotecan	Topotecan may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Torasemide	Torasemide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Tositumomab	Tositumomab may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Tramadol	Tramadol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Trametinib	Trametinib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Triamcinolone	The metabolism of Ixazomib can be increased when combined with Triamcinolone.
Triamterene	Triamterene may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam	Triazolam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Trichlormethiazide	Trichlormethiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Triclabendazole	The metabolism of Ixazomib can be decreased when combined with Triclabendazole.
Triethylenetetramine	Triethylenetetramine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Trifluridine	Trifluridine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Trimebutine	Trimebutine may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Trimethoprim	Trimethoprim may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Trimetrexate	Trimetrexate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Troglitazone	The metabolism of Ixazomib can be increased when combined with Troglitazone.
Troleandomycin	The metabolism of Ixazomib can be decreased when combined with Troleandomycin.
Tropisetron	Ixazomib may decrease the excretion rate of Tropisetron which could result in a higher serum level.
Tucatinib	The metabolism of Tucatinib can be decreased when combined with Ixazomib.
Vaborbactam	Ixazomib may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
Valaciclovir	Valaciclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Valbenazine	Ixazomib may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Valdecoxib	Valdecoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Valganciclovir	Valganciclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Valproic acid	The metabolism of Ixazomib can be decreased when combined with Valproic acid.
Vancomycin	Ixazomib may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Varenicline	Varenicline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Vemurafenib	The metabolism of Ixazomib can be increased when combined with Vemurafenib.
Venetoclax	The metabolism of Ixazomib can be decreased when combined with Venetoclax.

Pregnancy and Lactation

AU TGA pregnancy category: C
US FDA pregnancy category: Not assigned.

Pregnancy

This drug can cause fetal harm when administered to a pregnant woman. Females of reproductive potential should be advised to avoid becoming pregnant while being treated with this drug. Male and female patients of reproductive potential should use effective contraceptive measures during and for 90 days following therapy with this drug. Females using oral hormonal contraceptives should additionally use a barrier method of contraception. Based on animals and the drug mechanism of action, this drug can cause fetal harm.

Lactation

No information is available on the clinical use of ixazomib during breastfeeding. Because its half-life is about 9.5 days, it is likely to accumulate in the infant. It is also given in combination with leflunomide and dexamethasone, which may increase the risk to the infant. The manufacturer recommends that breastfeeding be discontinued during ixazomib therapy and for 90 days after the last dose.

Why is this medication prescribed?

Ixazomib is used in combination with lenalidomide (Revlimid) and dexamethasone to treat multiple myeloma (cancer of the plasma cells in the bone marrow) that has worsened after treatment with other chemotherapy medications. Ixazomib is in a class of medications called proteasome inhibitors. It works by helping to kill cancer cells.

How should this medicine be used?

Ixazomib comes as a capsule to take by mouth. It is usually taken with water on an empty stomach, at least 1 hour before or 2 hours after eating. It is taken on days 1,8, and 15 of a 28 day treatment cycle. Take ixazomib at around the same time on every day that you take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ixazomib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not take ixazomib and dexamethasone at the same time because you should take dexamethasone with food.

Swallow the capsules whole; do not split, chew, or crush them.

Be careful when handling ixazomib capsules. Do not allow your skin, eyes, mouth, or nose to come into contact with broken or crushed ixazomib capsules. If such contact occurs, wash your skin well with soap and water or rinse your eyes well with plain water.

If you vomit after taking ixazomib, do not repeat the dose. Take your next dose of ixazomib on the next scheduled day that you are supposed to take it.

Your doctor may need to temporarily or permanently stop your treatment or decrease your dose of ixazomib, or of the other medications that you are taking, depending on the side effects that you experience. Be sure to talk to your doctor about how you are feeling during your treatment. Do not stop taking ixazomib without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking ixazomib,

tell your doctor and pharmacist if you are allergic to ixazomib, any other medications, or any of the ingredients in ixazomib capsules. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Epitol, Equetro, Carbatrol, Tegretol, Teril), efavirenz (Sustiva, in Atripla), nevirapine (Viramune), phenobarbital, pioglitazone (Actos, in Actoplus, Duetact, Oseni), phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), and rifampin (Rifadin, Rimactane, in Rifamate, Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor what herbal products you are taking, especially St. John’s wort.
tell your doctor if you have or have ever had liver or kidney disease.
tell your doctor if you are pregnant or plan to become pregnant, or plan to father a child. You should not become pregnant while you are taking ixazomib. Use effective birth control during your treatment with ixazomib and for 90 days after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for 90 days after your final dose. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while taking ixazomib, call your doctor immediately. Ixazomib can harm the fetus.
tell your doctor if you are breastfeeding. You should not breastfeed while you are taking ixazomib.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is within 72 hours (3 days) of your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

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Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

Write when the problem started and how it changed.
Bring old prescriptions, investigation reports, and current medicines.
Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

What is the most likely cause of my symptoms?
Which danger signs mean I should go to hospital quickly?
Which tests are necessary now, and which can wait?
How should I take medicines safely and what side effects should I watch for?
When should I come for follow-up?

Tests to discuss

Vital signs: temperature, pulse, blood pressure, oxygen saturation
Basic physical examination by a clinician
CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

Avoid heavy lifting, sudden bending, and prolonged bed rest.
Use comfortable posture and gentle movement as tolerated.
Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

Do not start antibiotics without a proper medical decision.
Do not use steroid tablets or injections casually for quick relief.
Do not delay emergency care because of home remedies.

Get urgent help if

Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.

Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Orthopedic / spine specialist, physical medicine doctor, or qualified clinician

Tests to discuss with doctor

Neurological examination for leg power, sensation, reflexes, and straight leg raise
X-ray only if injury, deformity, long-lasting pain, or doctor suspects bone problem
MRI discussion if severe nerve symptoms, weakness, bladder/bowel problem, or persistent symptoms

Questions to ask

What is the most likely cause of my symptoms?
Which warning signs mean I should go to emergency care?
Which tests are really needed now?
Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?
Is physiotherapy, posture correction, or activity modification needed?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Go to emergency care if you notice:

Severe or rapidly worsening symptoms
Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration

Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.

Step 1
Check danger signs first

If danger signs are present, seek emergency care and do not wait for online information.
Step 2
Record the symptom story

Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.
Step 3
Visit a qualified clinician

A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.
Step 4
Do only useful tests

Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.
Step 5
Follow up and return early if worse

If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips

Take a written symptom diary and all previous prescriptions/test reports.
Do not hide medicines already taken, even herbal or over-the-counter medicines.
Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

Internal learning pathway

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Article Summary

Key Takeaways

RX Patient Tools

Mechanism of Action

Indications

Use in Cancer

Contraindications

Dosage?

Multiple Myeloma

Dose Adjustments

Side Effects

The Most Common

More common

Rare

Drug Interaction

Pregnancy and Lactation

Pregnancy

Lactation

Why is this medication prescribed?

How should this medicine be used?

What special precautions should I follow?

Before taking ixazomib,

What should I do if I forget a dose?

Related medical topics

Related Articles

Prepare before seeing a doctor

Which doctor may help?

What to tell the doctor

Questions to ask

Tests to discuss

Avoid these mistakes

Medicine safety and first-aid guide

Safe first steps

OTC medicine safety

Avoid these mistakes

Get urgent help if

Patient health record and symptom diary

Care roadmap for: Ixazomib Citrate – Uses, Dosage, Side Effects, Interaction

Check danger signs first

Record the symptom story

Visit a qualified clinician

Do only useful tests

Follow up and return early if worse

Explore related RX articles

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