What is Chagas Disease
Chagas disease is caused by a parasite called Trypanosoma cruzi, sometimes called a kissing bug and related to the African trypanosome that causes sleeping sickness. It is one of the major health ...
Rx Autoimmune, Genetic and Rare Diseases (A – Z)
What is Castleman Disease (CD)
Castleman disease (CD) is a rare disease of lymph nodes and related tissues. It is also called giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH). Castleman disease can ...
What Is Bullous Pemphigoid
Bullous pemphigoid is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Bullous pemphigoid ...
Benign Mucosal Pemphigoid
Cicatricial pemphigoid (also known as benign mucosal pemphigoid, mucous membrane pemphigoid, or benign mucous membrane pemphigoid) is a rare chronic autoimmune blistering disease characterized by ...
Behcet’s Disease
Behcet’s disease is a chronic, multisystem autoimmune disease involving inflammation of blood vessels, called vasculitis, throughout the body. It is a rare disease, most commonly found in the Eastern ...
What is Baló Disease
Baló’s concentric sclerosis (BCS) is a rare disorder usually considered a variant of multiple sclerosis (MS). However, its correlation with MS remains unclear and controversial. Balo’s disease is a ...
X-Linked Agammaglobulinemia
X-linked agammaglobulinemia (a-gam-uh-glob-u-lih-NEE-me-uh) — also called XLA — is an inherited (genetic) immune system disorder that reduces your ability to fight infections. People ...
Addison’s Disease
Addison’s disease is an uncommon autoimmune disease, characterized by chronic and insufficient functioning of the outer layer of the adrenal gland. The adrenal glands are located atop each kidney and ...
Achalasia
Achalasia is a rare disorder that makes it difficult for food and liquid to pass into your stomach. Achalasia occurs when nerves in the tube connecting your mouth and stomach (esophagus) become ...
Lichen Amyloidosis
Lichen amyloidosis may sound complicated, but we're here to break it down for you in simple terms. In this article, we'll explain what lichen amyloidosis is, its types, causes, symptoms, diagnostic ...
Lesch-Nyhan Syndrome
Lesch-Nyhan Syndrome (LNS) is a rare and complex genetic disorder that affects a person's ability to control their muscle movements and can lead to a range of physical and behavioral symptoms. In ...
Lafora Disease
Lafora disease is a rare and devastating genetic disorder that affects the brain. In this article, we will break down the complex aspects of Lafora disease into simple, easy-to-understand language. ...
Idiopathic Scrotal Calcinosis
Idiopathic scrotal calcinosis is a rare condition that affects the scrotum, causing the development of small, painless nodules or lumps made up of calcium deposits. Despite its somewhat intimidating ...
Iatrogenic Calcinosis Cutis
Iatrogenic calcinosis cutis is a condition where calcium deposits build up in the skin due to medical treatments or interventions. This article aims to explain this condition in simple terms, ...
Mucopolysaccharidosis Type IX (MPS IX)
Mucopolysaccharidosis Type IX, commonly known as MPS IX, is a rare genetic disorder that affects the body's ability to break down and recycle certain substances. In this article, we will provide you ...
Hyaluronidase Deficiency
Hyaluronidase deficiency is a rare genetic disorder that affects the body's ability to break down a substance called hyaluronic acid. This deficiency can lead to various health problems, and ...
Mucopolysaccharidosis Type I H-S
Mucopolysaccharidosis Type I H-S, often abbreviated as MPS I H-S, is a rare genetic disorder that affects the body's ability to break down certain substances. In this article, we will provide you ...
Hurler-Scheie Syndrome
Hurler-Scheie syndrome, a rare genetic disorder, affects various aspects of a person's health. In this simplified guide, we will explore what Hurler-Scheie syndrome is, its types, causes, symptoms, ...
Mucopolysaccharidosis Type I (MPS I)
Mucopolysaccharidosis Type I, often referred to as MPS I, is a rare genetic disorder that affects the body's ability to break down certain substances. This article aims to provide a clear and ...
Gargoylism
Gargoylism, also known as Hurler syndrome or mucopolysaccharidosis type I, is a rare genetic disorder that affects various parts of the body, leading to a range of physical and developmental ...
Hurler Syndrome
Hurler Syndrome is a rare genetic disorder that primarily affects children. It falls under a group of disorders called mucopolysaccharidoses (MPS), which are characterized by the buildup of harmful ...
What is Hunter Syndrome?
Hunter syndrome, also known as mucopolysaccharidosis II (MPS II), is a rare genetic disorder that primarily affects boys. This condition can be complex, but in this article, we'll break it down into ...
Hereditary Gelsolin Amyloidosis
Hereditary Gelsolin Amyloidosis (HGA) is a rare genetic disorder that affects a person's ability to properly break down a protein called gelsolin. This condition can lead to the buildup of abnormal ...
Hereditary Coproporphyria (HCP)
Hereditary coproporphyria (HCP) is a rare genetic disorder that affects the way your body produces heme, a crucial component of hemoglobin. Hemoglobin is the protein responsible for carrying oxygen ...
Hemodialysis-Associated Amyloidosis
Hemodialysis-associated amyloidosis, often referred to as HAA, is a condition that can develop in people who undergo long-term hemodialysis treatment. This article aims to explain HAA in simple, ...
Hartnup Disease
Hartnup disease is a rare genetic disorder that affects the body's ability to absorb certain nutrients, primarily amino acids, and can lead to a range of symptoms. In this article, we'll break down ...
Gaucher’s Disease
Gaucher's disease is a rare genetic disorder that affects a person's ability to break down certain fatty substances in the body. In this article, we will provide clear and concise explanations for ...
Fibrocytic Dysmucopolysaccharidosis
Fibrocytic dysmucopolysaccharidosis might sound complex, but we'll break it down in simple terms. This is a rare genetic disorder that affects how our bodies process certain substances. In this ...
Farber Disease
Farber disease is a rare genetic disorder that affects various aspects of a person's health. This article aims to provide a clear and concise overview of Farber disease, its types, causes, symptoms, ...
Tangier Disease
Tangier Disease is a rare genetic disorder that affects the body's ability to process fats properly. In this article, we will break down what Tangier Disease is, its types, causes, symptoms, ...
Gunther’s Disease
Gunther's disease, also known as congenital erythropoietic porphyria (CEP), is a rare genetic disorder that affects the production of heme, an essential component of hemoglobin. Hemoglobin is ...
Adrenoleukodystrophy
Adrenoleukodystrophy (ALD) is a rare genetic disorder that affects the nervous system. In this article, we will provide simple explanations for various aspects of ALD, including its types, causes, ...
Pyogenic Arthritis–Pyoderma Gangrenosum–Acne Syndrome
Pyogenic Arthritis–Pyoderma Gangrenosum–Acne Syndrome, often referred to as PAPA syndrome, is a rare genetic disorder that affects the skin and joints. This article aims to provide a simplified, ...
Neutrophilic Eccrine Hidradenitis (NEH)
Neutrophilic Eccrine Hidradenitis (NEH) is a rare skin condition that can cause discomfort and distress. In this article, we will break down NEH into simple terms to help you understand its types, ...
Neutrophilic Dermatosis
Neutrophilic dermatosis is a group of skin conditions characterized by inflammation and the presence of a type of white blood cell called neutrophils in the skin. These conditions can cause various ...
Marshall Syndrome
Marshall Syndrome is a rare genetic disorder that affects various parts of the body. In this article, we will break down the complex medical jargon into simple language to help you understand ...
Richner-Hanhart Syndrome
Richner-Hanhart syndrome, also known as Tyrosinemia Type II, is a rare genetic disorder that affects how the body processes an amino acid called tyrosine. This condition can lead to various health ...
Sybert Keratoderma
Sybert Keratoderma, also known as palmoplantar keratoderma type 1 (PPK1), is a rare genetic skin condition that primarily affects the palms of the hands and the soles of the feet. In this article, we ...
Greither Syndrome
Greither syndrome, also known as Greither's syndrome or lipodystrophy type 4, is a rare genetic disorder that affects the way the body stores and uses fat. This condition can lead to a variety of ...
Jackson–Sertoli Syndrome
Jackson–Sertoli Syndrome, also known as JSS, is a rare medical condition that primarily affects males. This condition can lead to a variety of symptoms and complications. In this article, we will ...
Naxos Syndrome
Naxos syndrome is a rare genetic condition that primarily affects the skin, hair, and heart. In this article, we'll break down Naxos syndrome in simple terms, explaining its types, causes, symptoms, ...
Keratitis–Ichthyosis–Deafness Syndrome (KID Syndrome)
Keratitis–ichthyosis–deafness syndrome, also known as KID syndrome, is a rare genetic disorder that affects various parts of the body, including the skin, eyes, and ears. In this simplified article, ...
Keratosis Davis Colley Disease
Keratosis Davis Colley Disease, also known as KDC disease, is a rare skin condition that can cause various symptoms and discomfort. In this article, we will provide you with a clear and simple ...
Keratoderma Haxthausen’s Disease
Keratoderma Haxthausen's disease, also known as palmoplantar keratoderma (PPK), is a rare skin disorder that affects the palms of the hands and soles of the feet. In this article, we will provide ...
Hystrix-Like Ichthyosis-Deafness Syndrome
Hystrix-Like Ichthyosis-Deafness Syndrome is a rare genetic condition that affects the skin and hearing abilities of individuals. In this article, we will provide simplified explanations of its ...
Hystrix-Like Ichthyosis
Hystrix-like ichthyosis is a rare skin condition that can cause significant discomfort and affect a person's quality of life. In this article, we will simplify the complex medical jargon to provide ...
Palmoplantar Keratoderma Tylosis
Tylosis is a rare genetic condition that affects the skin, mouth, and esophagus. In this article, we'll explain tylosis in simple terms, covering its types, causes, symptoms, diagnostic tests, ...
Palmoplantar Keratoderma Associated with Esophageal Cancer
Palmoplantar keratoderma (PPK) is a condition that affects the skin on the palms of your hands and the soles of your feet, making them thick and hard. In some cases, PPK can be associated with ...
Howel-Evans Syndrome
Howel-Evans syndrome is a rare genetic disorder that affects the skin and can increase the risk of developing certain types of cancer. In this article, we'll provide simple explanations for the ...
Fischer-Jacobsen-Clouston Syndrome
Fischer-Jacobsen-Clouston syndrome is a rare genetic disorder that can affect various parts of the body. In this article, we'll break down what this syndrome is, its types, causes, symptoms, ...
Clouston’s Hidrotic Ectodermal Dysplasia
Clouston's Hidrotic Ectodermal Dysplasia (HED) is a rare genetic disorder that affects various parts of the body. In this article, we'll provide clear and concise explanations for key aspects of HED, ...
What Is Clouston Syndrome
Clouston Syndrome is a rare genetic condition that affects a person's hair, nails, and skin. This article aims to provide simple explanations for different aspects of Clouston Syndrome, making it ...
Arachnodactyly
Arachnodactyly is a medical condition that affects the fingers and toes, causing them to appear long and slender, resembling spider legs. In this article, we will provide simple explanations for what ...
Acro-Osteolysis
Acro-osteolysis is a medical condition that affects the bones in your fingers and toes. In this article, we will break down what acro-osteolysis is and provide simple explanations for its types, ...
Haim-Munk Syndrome
Haim-Munk Syndrome is a rare genetic disorder that affects various parts of the body, including the skin, nails, and bones. In this article, we will provide simple explanations for the types, causes, ...
Corneodermatoosseous Syndrome
Corneodermatoosseous syndrome is a genetic disorder that impacts multiple systems within the body. It falls under a group of conditions called ectodermal dysplasias, which affect tissues derived from ...
Palmoplantar Keratoderma with Knuckle Pads, Leukonychia, and Deafness
Palmoplantar keratoderma (PPK) with knuckle pads, leukonychia, and deafness is a rare genetic disorder that affects the skin, nails, and hearing. In this article, we will provide simple and clear ...
X-Linked Neutropenia
X-Linked Neutropenia is a rare genetic condition that affects the immune system. This article aims to provide simple, easy-to-understand explanations for its types, causes, symptoms, diagnostic ...
Duncan’s Disease
Duncan's Disease is a relatively uncommon medical condition that can affect people of all ages. In this article, we will simplify the complex medical jargon and provide clear, easy-to-understand ...
X-Linked Lymphoproliferative Disease (XLP)
X-linked lymphoproliferative Disease (XLP) is a rare genetic disorder that affects the immune system, primarily in males. This article aims to provide a simplified overview of XLP, including its ...
X-Linked Hypogammaglobulinemia (XLA)
X-Linked Hypogammaglobulinemia (XLA), also known as Bruton's agammaglobulinemia, is a rare genetic disorder that affects the immune system. This article will provide simplified definitions and ...
X-Linked Hyper-IgM Syndrome
X-Linked Hyper-IgM Syndrome (XHIGM) is a rare genetic disorder that affects the immune system. This condition primarily affects males and can lead to recurrent infections and other health problems. ...
X-Linked Agammaglobulinemia
Sex-linked agammaglobulinemia, also known as X-linked agammaglobulinemia (XLA), is a rare genetic disorder that affects the immune system. This condition primarily affects males and leads to a ...
Bruton Syndrome
Bruton syndrome, also known as X-linked agammaglobulinemia (XLA), is a rare genetic disorder that affects the immune system. In this article, we will provide simple explanations for various aspects ...
X-Linked Agammaglobulinemia (XLA)
X-Linked Agammaglobulinemia (XLA), also known as Bruton's agammaglobulinemia, is a rare genetic disorder that affects the immune system. In this article, we will explain XLA in simple, plain English, ...
Wiskott-Aldrich Syndrome (WAS)
Wiskott-Aldrich Syndrome (WAS) is a rare genetic disorder that affects the immune system and blood-clotting ability. In this article, we will provide simple, easy-to-understand explanations for ...
WHIM Syndrome
WHIM syndrome is a rare immune disorder that can affect various aspects of a person's health. This article aims to provide a straightforward explanation of WHIM syndrome, including its types, causes, ...
Myelokathexis Syndrome
Myelokathexis syndrome is a rare and complex condition that affects the bone marrow and can lead to various health problems. In this article, we will provide simple explanations for different aspects ...
Warts Hypogammaglobulinemia Infections
Warts, hypogammaglobulinemia, and infections are health conditions that can affect people of all ages. In this comprehensive guide, we will break down these topics into simple, easy-to-understand ...
Transient Hypogammaglobulinemia of Infancy (THI)
Transient Hypogammaglobulinemia of Infancy (THI) is a temporary condition that affects young children. It can make their immune systems weaker for a while, making them more vulnerable to infections. ...
Good Syndrome
Good Syndrome is a rare medical condition that affects the immune system. It's essential to understand the various aspects of Good Syndrome, including its types, causes, symptoms, diagnostic tests, ...
Thymoma with Immunodeficiency
Thymoma with immunodeficiency is a rare condition that affects the thymus gland, a small organ located in the chest, and can lead to a weakened immune system. In this article, we will provide ...
Shwachman Bodian Diamond Syndrome
Shwachman–Bodian–Diamond Syndrome, often abbreviated as SBDS, is a rare genetic disorder that affects various parts of the body, particularly the bone marrow, pancreas, and skeletal system. This ...
Thymic Alymphoplasia
Thymic alymphoplasia, also known as DiGeorge syndrome, is a rare genetic disorder that affects the immune system's development. It occurs when the thymus gland, a vital part of the immune system, ...
Severe Mixed Immunodeficiency Syndrome (SMIDS)
Severe Mixed Immunodeficiency Syndrome (SMIDS) is a rare and serious medical condition that affects the immune system's ability to defend the body against infections. In this article, we will break ...
Glanzmann-Riniker Syndrome
Glanzmann-Riniker Syndrome, often called Glanzmann-Thrombasthenia, is a rare genetic disorder that affects your blood's ability to clot properly. In this easy-to-understand guide, we will break down ...
Alymphocytosis
Alymphocytosis is a condition characterized by a decrease in the number of lymphocytes in the blood. Lymphocytes are a type of white blood cell that plays a crucial role in our immune system. When ...
Severe Combined Immunodeficiency (SCID)
Severe Combined Immunodeficiency (SCID) is a rare but serious medical condition that affects the immune system. In this article, we will provide clear and straightforward explanations of what SCID ...
Purine Nucleoside Phosphorylase Deficiency
Purine Nucleoside Phosphorylase Deficiency, or PNP deficiency for short, is a rare genetic disorder that affects the way our body processes certain molecules called purines. In this article, we'll ...
Omenn Syndrome
Omenn syndrome is a rare and severe genetic disorder that affects the immune system. In this article, we will break down everything you need to know about Omenn syndrome in plain, simple language. We ...
Thymic Dysplasia with Normal Immunoglobulins
Thymic dysplasia with normal immunoglobulins is a rare medical condition that affects the thymus, a crucial organ for our immune system. In this article, we will explain this condition in plain and ...
Nezelof Syndrome
Nezelof syndrome, also known as Severe Combined Immunodeficiency (SCID) with microcephaly and growth retardation, is a rare genetic disorder that affects the immune system, growth, and development of ...
Neutrophil Immunodeficiency Syndrome
Neutrophil Immunodeficiency Syndrome is a rare medical condition that affects the body's ability to fight off infections. In this article, we will break down this complex topic into ...
Myeloperoxidase Deficiency
Myeloperoxidase deficiency is a rare genetic condition that affects the immune system. People with this condition have lower levels of a protein called myeloperoxidase, which plays a crucial role in ...
LIG4 Syndrome
LIG4 syndrome is a rare genetic disorder that affects the body's ability to repair damaged DNA. In this article, we will provide simple and easy-to-understand explanations of LIG4 syndrome, including ...
Leukocyte Adhesion Deficiency
Leukocyte Adhesion Deficiency (LAD) is a rare genetic disorder that affects the body's ability to fight off infections. In simple terms, it makes the body's defense system less effective in warding ...
Janus Kinase 3 Deficiency
Janus kinase 3 deficiency, also known as JAK3 deficiency, is a rare genetic disorder that affects the immune system's ability to function properly. This condition can lead to various health problems ...
Isolated Primary IgM Deficiency
Isolated Primary IgM Deficiency (IPID) is a relatively rare immune system disorder that affects a person's ability to produce a type of antibody called Immunoglobulin M (IgM). In this article, we ...
Isolated IgA Deficiency
Isolated IgA deficiency is a rare immune system disorder where your body doesn't produce enough IgA antibodies, which are crucial for fighting infections. In this article, we'll break down the types, ...
Facial Anomalies Syndrome
Facial anomalies syndrome, also known as craniofacial anomalies or facial dysmorphology syndrome, encompasses a wide range of conditions that affect the appearance and structure of a person's face. ...
Immunodeficiency-Centromeric Instability (ICI)
Immunodeficiency-centromeric instability (ICI) is a rare genetic disorder that affects the immune system. In this article, we'll break down ICI into simple terms, explaining its types, causes, ...
Immunodeficiency with Hyper-IgM
Immunodeficiency with Hyper-IgM (HIgM) is a rare genetic disorder that affects the immune system. In this article, we will break down the complex aspects of HIgM into simple, easy-to-understand ...
Job Syndrome
Job syndrome, also known as Hyper IgE syndrome (HIES), is a rare genetic disorder that affects the immune system. In this article, we'll break down Job syndrome in simple terms to help you understand ...
Buckley Syndrome
Buckley syndrome is a rare medical condition that affects the immune system, making it weaker than normal. In this article, we will break down the syndrome's types, causes, symptoms, diagnostic ...
Hyper-IgE Syndrome
Hyper-IgE syndrome, also known as Job's syndrome, is a rare genetic disorder that affects the immune system. People with this condition have elevated levels of a type of antibody called ...
Griscelli Syndrome
Griscelli syndrome is a rare genetic disorder that affects a person's ability to produce and distribute pigment in their body. This condition can lead to various health issues, and it's important to ...
Graft-Versus-Host Disease
Graft-versus-host disease (GVHD) is a complex medical condition that can occur after a bone marrow or stem cell transplant. In GVHD, the newly transplanted cells (graft) attack the recipient's body ...
DiGeorge Anomaly
DiGeorge anomaly, also known as 22q11.2 deletion syndrome or velocardiofacial syndrome, is a rare genetic disorder that can affect various parts of the body. This article aims to provide a ...
DiGeorge Syndrome
DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a genetic disorder that affects various parts of the body. In this article, we will break down this complex condition into simple, ...
Acquired Hypogammaglobulinemia
Acquired hypogammaglobulinemia is a condition where the body doesn't produce enough antibodies to fight off infections. In simple terms, it weakens your immune system. In this article, we'll break ...
Common Variable Immunodeficiency
Common Variable Immunodeficiency (CVID) is a condition that affects the immune system, making it less effective in fighting off infections. In this article, we will provide you with straightforward ...
Granulomatous Quie Syndrome
Granulomatous Quie Syndrome, often referred to as GQS, is a condition that impacts the immune system's ability to function properly. It falls under a category of illnesses known as primary ...
Chronic Granulomatous Disease (CGD):
Chronic Granulomatous Disease, or CGD for short, is a rare genetic disorder that affects the immune system's ability to fight off infections. In this article, we will break down the essential ...
Bridges-Good Syndrome:
Bridges-Good syndrome is a rare medical condition that affects the immune system. In this article, we'll break down Bridges-Good syndrome into simple terms to help you understand its types, causes, ...
Bare Lymphocyte Syndrome
Bare Lymphocyte Syndrome (BLS) is a rare immune system disorder that affects a person's ability to fight off infections. In this article, we will simplify and explain BLS in plain English, covering ...
Riley-Day syndrome
Riley-Day syndrome, also known as familial dysautonomia (FD), is a rare genetic disorder that affects the autonomic nervous system. In this article, we'll break down this complex condition into ...
Roth-Bernhardt Disease
Roth-Bernhardt disease, also known as RBD, is a rare medical condition that affects the body's ability to process and utilize certain nutrients. In this article, we will provide a simple and clear ...
Orodynia
Orodynia is a medical term that refers to pain or discomfort in the mouth or oral cavity. This condition can be caused by various factors and can manifest in different ways. In this article, we will ...
Jadassohn–Dosseker Syndrome
Jadassohn–Dosseker syndrome, also known as Jadassohn–Dosseker type of incontinentia pigmenti (IP), is a rare genetic disorder that affects the skin, hair, nails, and teeth. In this article, we'll ...
Montgomery Syndrome
Montgomery syndrome is a rare genetic disorder that affects various aspects of a person's health. In this article, we will break down the different types of Montgomery syndrome, explore its causes, ...
Darier-Roussy Disease
Darier-Roussy disease, also known as Darier's disease or keratosis follicularis, is a rare genetic skin disorder that affects the way skin cells behave. In this article, we will provide simple, ...
Non-X Histiocytosis
Non-X histiocytosis is a rare group of disorders that affect the body's immune system, specifically a type of white blood cell called histiocytes. These disorders can have a variety of causes, ...
