The Auditory System – Anatomy, Blood and Nerve Supply

Structure of The Auditory System

Peripheral Auditory System: How sound reaches the brain.

Sounds are produced by energy waves. Energy waves travel through a medium by moving molecules. This causes increases and decreases in pressure (i.e., alternating compression and rarefaction) of air within the environment. The number of periods of compression and rarefaction within a specified amount of time is the frequency of a specific sound. We measure frequency in Hertz (Hz; cycles of compression and rarefaction per second). Humans typically hear within a frequency range of 20-20,000 Hz.

Sound waves reach the outer ear and travel down the external acoustic meatus to reach the eardrum (tympanic membrane). Contact between the eardrum and environmental pressure waves causes movement of the membrane. Movement of the tympanic membrane initiates vibration of 3 small bones within the middle ear: the malleus, incus, and stapes which transfer the vibration to the inner ear at the oval (vestibular) window.

The 3 middle ear bones amplify this energy and transfer it into the cochlea. Within the cochlea, mechanical energy converts to electrical energy by auditory receptor cells (hair cells). This conversion occurs within the cochlea of the inner ear. The cochlea is a fluid-filled (perilymph) structure that spirals 2 ½ turns around a central pillar (modiolus). In cross-section, each aspect of the cochlea has 3 sections: the scala tympani, scala vestibule, and scala media (Figure 2). The scala tympani lies within the outer portion of the cochlea. It is continuous with the scala vestibule (lining the inner portion of the cochlea) at the helicotrema. Between these fluid-filled areas is the scala media. Oscillation of the oval window induces waves through the scala tympani and then the scala vestibule of the cochlea. Waves from these regions press against and transmit wave energy to the scala media through the basilar membrane (within the floor of the scala media).

The Organ of Corti resides on the basilar membrane inside the scala media. It houses mechanical receptor cells: 3 rows of outer hair cells and one row of inner hair cells. The base of these cells is embedded within the basilar membrane. At the apex of each cell, stereocilia connect to a second membrane (tectorial membrane) within the scala media.

As the scala vestibule and scala tympani oscillate, the basilar membrane shifts with the tectorial membrane. This shift bends the stereocilia with respect to the cell body of the hair cells. Depending on the direction of the shift, the movement will mechanically open or closes potassium channels to facilitate activation or deactivation of the cell.

How the tectorial and basilar membranes move changes depending on the location within the cochlea. The anatomy of the region close to the oval window is stiffer and hair cell stereocilia shorter. Therefore, cells near the oval window (base of the cochlea) respond to high frequencies. As you move toward the apex of the cochlea, there is more flexibility within the cochlea and the stereocilia length is more than twice as long as hair cells at the base. [rx] This shift in flexibility and altered anatomy influences how the basilar and tectorial membranes move and cause the hair cells to respond to lower frequencies. [rx] In this way graded flexibility allows hair cells within the cochlea to respond to a specific range of frequencies from high at the base to low at the apex of the cochlea. This arrangement of cells is called a tonotopic gradient.

Unlike other cells within the brain, hair cells within the Organ of Corti of the cochlea do not have axons. Neurons within the spinal ganglion have peripheral axons that synapse at the base of the hair cell soma. These axons make up the auditory nerve. Most (90%) of auditory nerve fibers receive their input from the inner hair cells. [rx] Thus, the inner hair cells facilitate a majority of auditory processing.

Outer hair cells synapse on only 10% of the spiral ganglion neurons. These neurons are special in that they can contract the length of their cell body which alters the stiffness? of the basilar membrane. This form of stiffening can dampen the excitation of hair cells and thus alter what sound transmits through the auditory system. [rx] Because the outer hair cells receive input from cortex, the cortex can start these changes to protect the health of hair cells in the presence of loud environments. [rx][rx] One example would be when an individual goes to a loud concert. Cortical feedback would initiate conformational changes to the outer hair cells to decrease movement within the cochlea (i.e., dampen the noise). When the individual leaves the concert, they may experience a loss of normal hearing for a few minutes and then resume normal hearing function. This delay is caused by the time needed for the descending circuits to reset anatomical morphology for the optimal audition in the new quieter environment.

Central Auditory System

Information from the peripheral auditory system reaches central auditory nuclei via the auditory nerve. The auditory nerve transmits auditory information up a series of nuclei to the cortex where perception occurs. These nuclei include

• 1) cochlear nucleus,
• 2) superior olivary nuclei,
• 3) lateral lemniscus,
• 4) inferior colliculus, and
• 5) medial geniculate nuclei. [rx] Auditory information ascending through the auditory pathways start at the auditory nerve. These nerves synapse within the cochlear nucleus. A majority of auditory information is then transmitted through crossing fibers into the superior olivary complex. From there, the information ascends through the contralateral side of the brainstem and brain to the cortex. It is of note that a significant number of neurons within the auditory system have crossing fibers at every level of the auditory system. This is likely due to the need for both ipsilateral and contralateral information for many aspects of auditory processing. Therefore, all levels of the central auditory system receive and process information from both the ipsilateral and contralateral sides.

Types of Processing

Different aspects of environmental sounds (e.g., attenuation: how loud the sound is; location in space; frequency, and combination sensitivity) are processed in each of the central auditory areas. Most of the auditory nuclei throughout the brain are tonotopically arranged. In this way, auditory signals ascending to the cortex can preserve the frequency information from the environment. [rx]

Attenuation (the intensity of a sound), is processed within the auditory system by neurons that fire action potentials at different rates based on the sound intensity. Most neurons respond by increasing their firing rate in response to increased attenuation. More specialized neurons respond maximally to environmental sounds within specific intensity ranges. [rx]

The brain processes the location of a sound in space by comparing differences in attenuation and timing of inputs from both ears within the superior olivary complex. If a sound is directly midline (i.e., front or back of the head), it would reach both ears at the same time. If it is to the right or left of midline, a temporal delay occurs between the inputs for the two ears. Within the superior olivary complex, specialized neurons receive input from both ears and can code for this temporal delay (i.e., binaural processing). [rx]

Combination-sensitive neurons are another subset of neurons within the auditory system that have either enhanced or inhibited responses specifically to 2 or more sounds with a specific temporal delay. Combination-sensitive neurons are located within the inferior colliculus, lateral lemniscus, medial geniculate, and auditory cortex. [rx][rx][rx][rx][rx] Because most sounds in the environment are not pure tones, these types of combination-sensitive neurons are thought to facilitate the enhancement of processing for combinations of sounds that may be important to the individual (e.g., speech, communication sounds). [rx]

Descending Circuits

It was once thought that auditory processing was a simple relay from the environmental signals up to the cortex. We now know that there is a significant descending system of circuits within the auditory system that helps to modulate auditory processing at every level. The auditory cortex has bilateral direct projections back to the inferior colliculus, superior olivary complex, and cochlear nucleus. [rx][rx][rx][rx][rx][rx][rx] These circuits contact neurons in these nuclei that project to every level of the central auditory system and to the cochlea (to modulate outer hair cells) within the peripheral auditory system. Connections between descending, ascending, and crossing fibers make the auditory system highly interconnected (Figure 1D). These descending circuits help to modulate auditory attention based on the relevance, attention, learned behaviors, and emotional state of an individual. Such higher-order functions originate from many regions of the brain (e.g., prefrontal cortex, hippocampus, nucleus basalis of Meynert, and limbic circuits) that have either direct and indirect connections with each other and auditory cortex. [rx][rx][rx][rx][rx][rx][rx]

Blood Supply of The Auditory System

Blood supply [rx] (Standring, 2008):

External ear

• Posterior auricular branch of the external carotid artery

Middle ear

• Mastoid branches from the posterior auricular arteries
• Occipital arteries
• Deep auricular arteries

Inner ear

• Anterior tympanic branch of the maxillary artery
• Stylomastoid branch of the posterior auricular artery
• Petrosal branch of the middle meningeal artery
• Labyrinthine artery (branch of the basilar or anterior inferior cerebellar artery)

Lymphatics of the ear

External ear

• Pre-auricular lymph nodes [rx]

Middle ear

• Retroauricular and junctional lymph nodes [rx]

Inner ear

• It is unclear whether the inner ear drains via a normal lymphatic system. Salt and Hirose [rx] proposed that the inner ear drains diffusely through the perilymph and bone.

Muscles of The Auditory System

There are no muscles within the auditory system. Two muscles (levator veli palatini and tensor veli palatini) assist with opening the auditory tube.

References