Keratosis Palmoplantar Transgressions et Progressions

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 8 min read
Patient Tools

Read, save, and share this guide

Use these quick tools to make this medical article easier to read, print, save, or share with a family member.

On this page5 sections

Article Summary

Keratosis palmoplantaris, also known as palmoplantar keratoderma, is a skin condition that affects the palms of the hands and the soles of the feet. In this article, we will provide you with a simple, easy-to-understand guide to keratosis palmoplantaris, including its types, causes, symptoms, diagnostic tests, treatments, and medications. We aim to make this information accessible and comprehensible for everyone. Types of Keratosis Palmoplantar Transgressions...

Key Takeaways

  • This article explains Causes of Keratosis Palmoplantar Transgressions et Progressions in simple medical language.
  • This article explains Symptoms of Keratosis Palmoplantar Transgressions et Progressions in simple medical language.
  • This article explains Diagnostic Tests for Keratosis Palmoplantar Transgressions et Progressions in simple medical language.
  • This article explains Treatments forKeratosis Palmoplantar Transgressions et Progressions in simple medical language.
Educational health guideWritten for patient understanding and clinical awareness.
Reviewed content workflowUse writer and reviewer profiles for stronger trust.
Emergency safety firstUrgent warning signs are highlighted below.
Reading text size
Definition

Keratosis palmoplantaris, also known as palmoplantar keratoderma, is a skin condition that affects the palms of the hands and the soles of the feet. In this article, we will provide you with a simple, easy-to-understand guide to keratosis palmoplantaris, including its types, causes, symptoms, diagnostic tests, treatments, and medications. We aim to make this information accessible and comprehensible for everyone.

Types of Keratosis Palmoplantar Transgressions et Progressions

Keratosis palmoplantaris comes in various forms, with some common types being:

  1. Diffuse Palmoplantar Keratoderma: This type results in thickened skin on the entire palm and sole.
  2. Focal Palmoplantar Keratoderma: This type causes areas of thickened skin on the palms and soles.
  3. Punctate Palmoplantar Keratoderma: Small, hardened bumps or dots appear on the palms and soles.
  4. Striate Palmoplantar Keratoderma: Raised streaks or bands form on the skin of the palms and soles.
  5. Unna-Thost Palmoplantar Keratoderma: It is an form with painful fissures and thickened skin on the palms and soles.

Causes of Keratosis Palmoplantar Transgressions et Progressions

Understanding the causes of keratosis palmoplantaris can help manage and prevent its . Here are 20 common causes:

  1. Factors: Most types of keratosis palmoplantaris have a genetic basis, meaning they can be inherited from parents.
  2. Mutations in Specific Genes: Changes in certain genes can lead to the development of this condition.
  3. Environmental Factors: Excessive exposure to friction, pressure, or irritants on the palms and soles can trigger keratosis palmoplantaris.
  4. Occupational Factors: Certain jobs that involve repeated hand or foot movements may contribute to the condition.
  5. Infections: Some infections can exacerbate or trigger palmoplantar keratoderma.
  6. Nutritional Deficiencies: Lack of essential nutrients like vitamins A and C can affect skin health.
  7. Hormonal Changes: Hormonal imbalances, such as during pregnancy, can sometimes lead to palmoplantar keratoderma.
  8. Disorders: Conditions like and can increase the risk.
  9. Excessive Sweating: Profuse sweating on the palms and soles can worsen the condition.
  10. : Uncontrolled diabetes may contribute to palmoplantar keratoderma.
  11. Obesity: Carrying excess weight can increase pressure on the feet, leading to thickened skin.
  12. Excessive Friction: Frequent rubbing or pressure on the palms and soles can cause calluses.
  13. Allergies: Allergic reactions to certain substances can affect the skin.
  14. Medications: Some medications may have side effects that result in keratosis palmoplantaris.
  15. Autoimmune Diseases: Conditions like and can impact skin health.
  16. Exposure to Chemicals: Contact with harsh chemicals without protection can lead to skin issues.
  17. Inflammatory Skin Disorders: Conditions like can worsen keratosis palmoplantaris.
  18. Infections: Certain viruses can exacerbate symptoms.
  19. Disorders: Thyroid dysfunction can affect skin health.
  20. Inherited Syndromes: Some inherited syndromes may include palmoplantar keratoderma as a symptom.

Symptoms of Keratosis Palmoplantar Transgressions et Progressions

Identifying the symptoms of keratosis palmoplantaris is crucial for early and management. Here are 20 common symptoms:

  1. Thickened Skin: Palms and soles become thicker than usual.
  2. Hardened Areas: The affected areas may feel tough and rough.
  3. Calluses: The formation of calluses on the palms and soles.
  4. Scaling: Skin may develop a scaly or flaky appearance.
  5. Cracks and Fissures: Painful cracks or fissures can occur.
  6. Redness: The skin may appear red or irritated.
  7. or Discomfort: Some individuals experience pain or discomfort when walking or using their hands.
  8. : Itchiness on the affected areas.
  9. Blisters: Fluid-filled blisters can develop.
  10. Yellowish Tinge: Skin may take on a yellowish color.
  11. : Swelling of the palms or soles may occur.
  12. Burning Sensation: Some people report a burning sensation.
  13. Palm and Sole Lines: The normal lines on palms and soles may become less visible.
  14. Sensitivity: Increased sensitivity to touch in affected areas.
  15. Nail Changes: Nails on fingers and toes may become thickened or discolored.
  16. Palmoplantar : Redness specifically on the palms and soles.
  17. Peeling Skin: Skin may peel, especially after prolonged exposure to water.
  18. Unpleasant Odor: Odor due to the accumulation of dead skin.
  19. Difficulty Walking: cases may make walking difficult.
  20. Psychological Impact: Emotional distress due to cosmetic concerns.

Diagnostic Tests for Keratosis Palmoplantar Transgressions et Progressions

Accurate diagnosis is essential for appropriate treatment. Here are 20 common diagnostic tests:

  1. Examination: A dermatologist visually assesses the skin’s condition.
  2. Patient History: Discussing symptoms, , and potential triggers.
  3. : A small skin sample is examined under a microscope.
  4. Genetic Testing: Identifying specific gene mutations.
  5. Blood Tests: Checking for underlying conditions like diabetes or thyroid disorders.
  6. Skin Scraping: Scraping off a small layer of skin for examination.
  7. X-rays: To rule out bone abnormalities.
  8. Dermatoscopy: Close-up examination using a dermatoscope.
  9. Patch Testing: To identify potential allergens.
  10. Skin Culture: Testing for or infections.
  11. Nail Clippings: Examination of nail changes.
  12. Electron Microscopy: High-resolution imaging of skin samples.
  13. Testing: Identifying allergens triggering symptoms.
  14. Immunohistochemistry: Using antibodies to detect specific proteins in skin cells.
  15. Skin pH Testing: Measuring the skin’s acidity levels.
  16. : In rare cases, to assess deeper tissue involvement.
  17. Dermoscopy: Close examination of skin using a handheld device.
  18. Skin Biopsy with Genetic Testing: Combining both to confirm diagnosis.
  19. Wood’s Lamp Examination: Using ultraviolet light to assess skin changes.
  20. Electrodiagnostic Tests: Measuring nerve function in affected areas.

Treatments forKeratosis Palmoplantar Transgressions et Progressions

Managing keratosis palmoplantaris involves various treatments to relieve symptoms. Here are 30 common treatment options:

  1. Emollients: Regular application of moisturizers to soften the skin.
  2. Topical Creams: creams containing salicylic acid or urea.
  3. Keratolytics: Medications that help remove thickened skin.
  4. Oral Medications: For severe cases, oral retinoids may be prescribed.
  5. : Exercises to improve hand and foot function.
  6. Orthotic Devices: Custom insoles or shoe modifications for comfort.
  7. Corticosteroids: Topical or injected to reduce inflammation.
  8. Phototherapy: UV light treatment under medical supervision.
  9. Chemical Peels: Using acids to exfoliate and soften the skin.
  10. Cryotherapy: Freezing therapy to remove hardened skin.
  11. Laser Therapy: Targeted laser treatment for symptom relief.
  12. Electrolysis: Electric current to remove thickened skin.
  13. Keratoplasty: Surgical removal of thickened skin patches.
  14. Tissue Softening Agents: To break down hardened skin.
  15. Pain Management: Over-the-counter pain relievers if needed.
  16. Physical Barrier Protection: Using gloves and socks to protect the skin.
  17. Moisture Control: Keeping the skin dry to prevent worsening.
  18. Avoiding Irritants: Identifying and avoiding triggers.
  19. Pedicures and Manicures: Professional care for nails.
  20. Massage Therapy: To improve blood circulation.
  21. Foot Baths: Soaking in warm water with Epsom salts.
  22. Nutritional Supplements: If deficiencies are detected.
  23. Lifestyle Modifications: Adjusting activities to reduce friction.
  24. Stress Management: Stress reduction techniques to prevent flare-ups.
  25. Hydration: Drinking plenty of water to keep skin hydrated.
  26. Adequate Rest: Ensuring enough sleep for skin repair.
  27. Wound Care: Proper cleaning and dressing for open sores.
  28. Psychological Support: Counseling for emotional well-being.
  29. Supportive Footwear: Comfortable shoes with cushioning.
  30. Consultation with a Dermatologist: Regular check-ups for ongoing management.

Medications for Keratosis Palmoplantar Transgressions et Progressions

Medications can play a vital role in managing keratosis palmoplantaris. Here are 20 drugs commonly used:

  1. Isotretinoin (Accutane): An oral retinoid for severe cases.
  2. Salicylic Acid Cream: Topical application to soften thickened skin.
  3. Urea Cream: A topical treatment to remove dead skin.
  4. Corticosteroid Cream: To reduce inflammation and redness.
  5. Tazarotene (Tazorac): A topical retinoid for symptom relief.
  6. Calcipotriene (Dovonex): Cream or ointment to control skin cell growth.
  7. Coal Tar Products: Shampoos, creams, or ointments for symptom relief.
  8. Methotrexate: An immunosuppressant used in severe cases.
  9. Acitretin (Soriatane): An oral retinoid for symptom management.
  10. Tacrolimus Ointment (Protopic): Immunosuppressive cream for symptom relief.
  11. Adalimumab (Humira): A biologic medication for severe cases.
  12. Etretinate: An oral retinoid used in certain situations.
  13. Ciclosporin (Neoral): An immunosuppressant for symptom control.
  14. Mycophenolate Mofetil: Immunosuppressive drug in resistant cases.
  15. Mometasone Furoate Cream: Topical corticosteroid for inflammation.
  16. Tretinoin (Retin-A): A topical retinoid for symptom relief.
  17. Ammonium Lactate Cream: To soften and moisturize the skin.
  18. Betamethasone Valerate Cream: A corticosteroid for symptom management.
  19. Dimethyl Sulfoxide (DMSO): A topical treatment for pain relief.
  20. Lidocaine Cream: Topical anesthetic for pain management.

Conclusion:

Keratosis palmoplantaris, though challenging, can be managed effectively with the right treatments and medications. Understanding its types, causes, symptoms, diagnostic tests, treatments, and medications is essential for individuals and their healthcare providers to develop an appropriate management plan. If you suspect you have keratosis palmoplantaris, consult a dermatologist for a proper diagnosis and personalized treatment. Remember that each case is unique, and the chosen treatment approach may vary from person to person.

 

Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.

  1. https://medlineplus.gov/skinconditions.html
  2. https://www.aad.org/about/burden-of-skin-disease
  3. https://www.usa.gov/federal-agencies/national-institute-of-arthritis-musculoskeletal-and-skin-diseases
  4. https://www.cdc.gov/niosh/topics/skin/default.html
  5. https://www.skincancer.org/
  6. https://illnesshacker.com/
  7. https://endinglines.com/
  8. https://www.jaad.org/
  9. https://www.psoriasis.org/about-psoriasis/
  10. https://books.google.com/books?
  11. https://www.niams.nih.gov/health-topics/skin-diseases
  12. https://cms.centerwatch.com/directories/1067-fda-approved-drugs/topic/292-skin-infections-disorders
  13. https://www.fda.gov/files/drugs/published/Acute-Bacterial-Skin-and-Skin-Structure-Infections—Developing-Drugs-for-Treatment.pdf
  14. https://dermnetnz.org/topics
  15. https://www.aaaai.org/conditions-treatments/allergies/skin-allergy
  16. https://www.sciencedirect.com/topics/medicine-and-dentistry/occupational-skin-disease
  17. https://aafa.org/allergies/allergy-symptoms/skin-allergies/
  18. https://www.nibib.nih.gov/
  19. https://rxharun.com/resources/category/resources/rxharun/article-types/skin-care-beauty/skin-diseases-types-symptoms-treatment/
  20. https://www.nei.nih.gov/
  21. https://en.wikipedia.org/wiki/List_of_skin_conditions
  22. https://en.wikipedia.org/?title=List_of_skin_diseases&redirect=no
  23. https://en.wikipedia.org/wiki/Skin_condition
  24. https://oxfordtreatment.com/
  25. https://www.nidcd.nih.gov/health/
  26. https://consumer.ftc.gov/articles/w
  27. https://www.nccih.nih.gov/health
  28. https://catalog.ninds.nih.gov/
  29. https://www.aarda.org/diseaselist/
  30. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets
  31. https://www.nibib.nih.gov/
  32. https://www.nia.nih.gov/health/topics
  33. https://www.nichd.nih.gov/
  34. https://www.nimh.nih.gov/health/topics
  35. https://www.nichd.nih.gov/
  36. https://www.niehs.nih.gov
  37. https://www.nimhd.nih.gov/
  38. https://www.nhlbi.nih.gov/health-topics
  39. https://obssr.od.nih.gov/
  40. https://www.nichd.nih.gov/health/topics
  41. https://rarediseases.info.nih.gov/diseases
  42. https://beta.rarediseases.info.nih.gov/diseases
  43. https://orwh.od.nih.gov/

 

More from this topic
  1. Congenital Cataract-Ichthyosis Syndrome

    Reading text sizeA−AA+ DefinitionCongenital cataract-ichthyosis syndrome is an extremely rare inherited disorder in which a baby is born with cataract and ichthyosis together. A cataract means...

    March 29, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  2. Collagen VI-Related Muscle Disorder

    Reading text sizeA−AA+ DefinitionCollagen VI-related muscle disorder is a group of rare genetic diseases that weaken the muscles of the body and also affect the soft...

    February 10, 2026 • Rx Musculoskeletal Conditions
  3. Carbohydrate Deficient Glycoprotein Syndrome Type IIh

    Reading text sizeA−AA+ DefinitionCarbohydrate deficient glycoprotein syndrome type IIh is a very rare inherited metabolic disease. It belongs to a group of diseases called congenital disorders...

    February 4, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  4. Component of Oligomeric Golgi Complex 6–Congenital Disorder of Glycosylation (COG6-CDG)

    Reading text sizeA−AA+ DefinitionComponent of oligomeric Golgi complex 6–congenital disorder of glycosylation (short name COG6-CDG) is a very rare genetic disease that affects how sugar chains...

    February 3, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  5. COG6-Congenital Disorder of Glycosylation (COG6-CDG, CDG2L)

    Reading text sizeA−AA+ DefinitionCOG6-congenital disorder of glycosylation (COG6-CDG, also called CDG2L) is a very rare genetic disease. It affects how the body adds sugar chains (glycans)...

    February 3, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  6. Cerebro-Oculo-Facio-Skeletal (COFS) Syndrome

    Reading text sizeA−AA+ DefinitionCerebro-oculo-facio-skeletal (COFS) syndrome is a very rare genetic disease that affects the brain, eyes, face and bones from before birth. It is present...

    February 3, 2026 • Rx ENT, Oral and Dental Health (A - Z)
  7. Hypertrichosis Hyperkeratosis Intellectual Disability and Distinctive Facial Features

    Reading text sizeA−AA+ DefinitionHypertrichosis, hyperkeratosis, intellectual disability, and distinctive facial features is a rare genetic condition that doctors now group under Coffin–Siris syndrome 1 (CSS1) or...

    February 3, 2026 • Rx Autoimmune, Genetic and Rare Diseases (A - Z)
  8. Cerebroretinal Microangiopathy with Calcifications and Cysts

    Reading text sizeA−AA+ DefinitionCerebroretinal microangiopathy with calcifications and cysts is a very rare inherited disease that mainly damages the tiny blood vessels in the brain and...

    February 1, 2026 • Rx Eye & Vision Care (A - Z)
  9. Clouston’s Hidrotic Ectodermal Dysplasia

    Reading text sizeA−AA+ DefinitionClouston’s hidrotic ectodermal dysplasia is a rare inherited skin and hair condition. It mainly affects the hair, nails and the thick skin on...

    January 31, 2026 • Rx Dermatology, Skin Disease, and Allergy
  10. Clouston Syndrome

    Reading text sizeA−AA+ DefinitionClouston syndrome is a rare condition that a person is born with. It mainly affects three things in the body: the hair, the...

    January 31, 2026 • Rx Pregnancy, Baby & Mom Care
Doctor visit helper

Prepare before seeing a doctor

A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
  • Bring old prescriptions, investigation reports, and current medicines.
  • Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
  • Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

  • What is the most likely cause of my symptoms?
  • Which danger signs mean I should go to hospital quickly?
  • Which tests are necessary now, and which can wait?
  • How should I take medicines safely and what side effects should I watch for?
  • When should I come for follow-up?

Tests to discuss

  • Vital signs: temperature, pulse, blood pressure, oxygen saturation
  • Basic physical examination by a clinician
  • CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

  • Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
  • Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
  • Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Avoid heavy lifting, sudden bending, and prolonged bed rest.
  • Use comfortable posture and gentle movement as tolerated.
  • Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
  • Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Doctor / qualified healthcare provider
Tests to discuss with doctor
  • Basic vital signs: temperature, pulse, blood pressure, oxygen level if needed
  • Relevant blood, urine, imaging, or specialist tests only after clinical assessment
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Keratosis Palmoplantar Transgressions et Progressions

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.