Top U.S.-Based AI Startups

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We hear the word “startup” often used, although not every new business is actually a startup company. Instead, startups are new companies created to solve a problem, bring a unique service or product to the public, or meet a particular demand, all while trying to...

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Article Summary

We hear the word “startup” often used, although not every new business is actually a startup company. Instead, startups are new companies created to solve a problem, bring a unique service or product to the public, or meet a particular demand, all while trying to find a workable, viable business model. AI, of course, stands for Artificial Intelligence and is another well-used term. So, what happens when...

Key Takeaways

  • This article explains Why Should You Work for an AI Startup? in simple medical language.
  • This article explains 12 Top U.S.-Based AI Startups in simple medical language.
  • This article explains Do You Want to Learn About Artificial Intelligence and Machine Learning? in simple medical language.
Educational health guideWritten for patient understanding and clinical awareness.
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Emergency safety firstUrgent warning signs are highlighted below.

Seek urgent medical care if you notice

These warning signs are general safety guidance. Local emergency numbers and clinical judgment should always come first.

  • Severe symptoms, breathing difficulty, fainting, confusion, or rapidly worsening illness.
  • New weakness, severe pain, high fever, or symptoms after a serious injury.
  • Any symptom that feels urgent, unusual, or unsafe for the patient.
1

Emergency now

Use emergency care for severe, sudden, rapidly worsening, or life-threatening symptoms.

2

See a doctor

Book a professional medical evaluation if symptoms persist, worsen, recur often, affect daily activities, or occur in a high-risk patient.

3

Learn safely

Use this article to understand possible causes, tests, treatment options, prevention, and questions to ask your clinician.

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Definition

We hear the word “startup” often used, although not every new business is actually a startup company. Instead, startups are new companies created to solve a problem, bring a unique service or product to the public, or meet a particular demand, all while trying to find a workable, viable business model.

AI, of course, stands for Artificial Intelligence and is another well-used term. So, what happens when we bring both popular concepts together? We’re about to find out since this article deals with the top dozen AI startups in the U.S.

There are many opportunities for jobs in the Artificial Intelligence field. Once you’ve finished reading this article, you’ll have a better idea of the U.S.-based AI startups that are the best career destinations for experienced or newly minted AI professionals.

Why Should You Work for an AI Startup?

The startup culture differs dramatically from traditional corporate culture. Startups have a greater sense of informality and flexibility and offer more chances to contribute and create, giving you higher visibility.

Startups typically offer more perks like stock options, greater independence, more responsibilities, better opportunities for learning, and more excitement overall. There also tends to be free food. After all, you’re getting in on the ground floor of a brand-new business, and you may even find yourself creating policies and procedures that future employees will have to follow!

The Artificial Intelligence field is still relatively new and growing fast, so it’s hardly surprising that it fits well with the startup business model. Startup culture is all about newness, excitement, innovation, and thinking outside the box, which dovetails nicely with Artificial Intelligence.

However, in the interests of full disclosure, working for a startup has its downsides. Although startups usually give you flexible schedules, your workweek could easily exceed the traditional 40-hour workweek, sometimes including after-hours, weekends, and even holidays. Also, some startups offer free food not out of the goodness of their hearts but because they want employees to stay at their desks and not go out for breakfast, coffee, or lunch.

Finally, startups are high-risk propositions. The company may take the business world by storm and be a smash hit, or it may collapse into failure and be tossed in the scrap heap of so many other defunct startups. Yours truly has worked for four different startups, and they all failed because the founders’ visions exceeded what the venture capitalists were willing to fund.

But if you’re cool with the risks and don’t mind working possibly long chaotic hours, go for it! The rewards can be well worth the risks.

So, let’s look at 12 of the top U.S.-based AI startups and pick out a good destination!

12 Top U.S.-Based AI Startups

  1. Cruise Automation: If you’re interested in the idea of self-driving cars, this is the startup for you! Cruise is a self-driving automobile company developing the technology for existing cars and offering all-electric, self-driving ride services.
  2. SoundHound: SoundHound uses speech recognition, voice searches, and other voice-enabled AI to let developers and business owners keep control over their brand image from anywhere. Their assistant app, Hound, incorporates their trademarked “Speech-to-Meaning” and “Deep Meaning Understanding” technologies, and Houndify, an AI platform, offers the world’s fastest speech recognition and voice search.
  3. People.ai: People.ai harnesses the power of AI technology to build an enterprise revenue platform that enables marketing, sales, and customer service teams to give their customers the best experiences through the analysis of revenue opportunities.
  4. Waymo: Waymo is another self-driving car company, starting as Google’s Self-Driving Car Project back in 2009. The company is perfecting the Waymo Driver, which emphasizes safety and accessibility.
  5. Argo.ai: Yep, another self-driving car company! This concept is clearly a popular technological field. Argo.ai is developing the Argo Autonomy Platform, a self-driving platform that will be used by businesses and consumers alike. Argo.ai has partnered with Ford, Lyft, WalMart, and Volkswagen.
  6.  Abnormal Security: Let’s take a break from self-driving cars and focus on a very hot topic: security in today’s IT world. Abnormal focuses on e-mail security, using AI to protect against many attacks such as malware, ransomware, phishing, social engineering, spam, internal account compromise, executive impersonation, supply chain compromise, and graymail.
  7. SambaNova: SambaNova is a complete AI solutions provider specializing in big data analytics and machine learning platforms. They incorporate AI-based technology such as Natural Language Processing, High-Resolution Imaging, and Recommendation Systems into their Dataflow-as-a-Service product, designed to transform businesses.
  8. DataRobot: Data science is a vast, rapidly growing field, and DataRobot has an automated machine learning platform that helps data scientists build and deploy accurate predictive models quickly and easily.
  9. Riskified: Online businesses must deal with fraud every day. Riskified helps e-commerce by using machine learning models that pull from over one billion online transactions to halt fraud attacks, streamline the checkout process, and identify legitimate, genuine shoppers. They count Prada, Ticketmaster, and Trip.com among their customers.
  10. Moveworks: Employee retention is a big issue today, considering how the pandemic has caused mass resignations, resulting in many businesses struggling with depleted staff. Moveworks has created an AI platform designed to improve a business’s relationship with its staff by offering improved employee support in IT, HR, facilities issues, targeted employee communications, and finance issues.
  11. Neuralink: If the idea of self-driving cars sounds like science fiction, wait until the day our brains can directly interface with computers! Neuralink’s mission is to boost the number of channels the brain can use to communicate with technology. Their initial goal is to help people with paralysis easily control computers and mobile devices, giving them more independence.
  12. Stem: Energy prices (especially oil) are volatile and can be affected by anything from an oil-rig fire to a worldwide pandemic to an all-out war. Stem uses AI to automate energy cost savings and protect against rate increases. In addition, Stem offers services in many different energy-saving fields such as utility bill optimization, energy storage, sustainability, and commercial EV charging.

Are you an AI and Machine Learning enthusiast? If yes, the Post Graduate Program in AI and Machine Learning is a perfect fit for your career growth.

Do You Want to Learn About Artificial Intelligence and Machine Learning?

If you’re psyched about the prospect of working for one of these exciting AI startups, but find yourself a bit light in the skills department, don’t worry; Simplilearn has you covered. Simplilearn’s AI and ML Bootcamp, held in collaboration with IBM and CalTech CTME, will make you an AI and ML expert.

The bootcamp covers the latest tools and technologies from the AI ecosystem, including masterclasses by Caltech faculty and IBM experts, along with hackathons and Ask Me Anything sessions hosted by IBM. In addition, you will learn key concepts like Statistics, Data Science with Python, Machine Learning, Deep Learning, NLP, and Reinforcement Learning.

According to Glassdoor, an AI Engineer can earn an annual average of $118,195. So check out Simplilearn today and get that AI career off to a great start!

Doctor visit helper

Prepare before seeing a doctor

A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
  • Bring old prescriptions, investigation reports, and current medicines.
  • Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
  • Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

  • What is the most likely cause of my symptoms?
  • Which danger signs mean I should go to hospital quickly?
  • Which tests are necessary now, and which can wait?
  • How should I take medicines safely and what side effects should I watch for?
  • When should I come for follow-up?

Tests to discuss

  • Vital signs: temperature, pulse, blood pressure, oxygen saturation
  • Basic physical examination by a clinician
  • CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

  • Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
  • Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
  • Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Avoid heavy lifting, sudden bending, and prolonged bed rest.
  • Use comfortable posture and gentle movement as tolerated.
  • Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
  • Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Doctor / qualified healthcare provider
Tests to discuss with doctor
  • Basic vital signs: temperature, pulse, blood pressure, oxygen level if needed
  • Relevant blood, urine, imaging, or specialist tests only after clinical assessment
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Top U.S.-Based AI Startups

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

RX Patient Help

Ask a health question safely

Write your symptom story. A health professional or site editor can review it before any answer is prepared. This box is not for emergency care.

Emergency first: Severe chest pain, breathing trouble, unconsciousness, stroke signs, severe injury, heavy bleeding, or rapidly worsening symptoms need urgent local medical care now.

Frequently Asked Questions

Why Should You Work for an AI Startup?

The startup culture differs dramatically from traditional corporate culture. Startups have a greater sense of informality and flexibility and offer more chances to contribute and create, giving you higher visibility. Startups typically offer more perks like stock options, greater independence, more responsibilities, better opportunities for learning, and more excitement overall. There also tends to be free food. After all, you’re getting in on the ground floor of a brand-new business, and you may even find yourself creating policies and procedures…

12 Top U.S.-Based AI Startups Cruise Automation: If you’re interested in the idea of self-driving cars, this is the startup for you! Cruise is a self-driving automobile company developing the technology for existing cars and offering all-electric, self-driving ride services. SoundHound: SoundHound uses speech recognition, voice searches, and other voice-enabled AI to let developers and business owners keep control over their brand image from anywhere. Their assistant app, Hound, incorporates their trademarked “Speech-to-Meaning” and “Deep Meaning Understanding” technologies, and Houndify, an AI platform, offers the world’s fastest speech recognition and voice search. People.ai: People.ai harnesses the power of AI technology to build an enterprise revenue platform that enables marketing, sales, and customer service teams to give their customers the best experiences through the analysis of revenue opportunities. Waymo: Waymo is another self-driving car company, starting as Google’s Self-Driving Car Project back in 2009. The company is perfecting the Waymo Driver, which emphasizes safety and accessibility. Argo.ai: Yep, another self-driving car company! This concept is clearly a popular technological field. Argo.ai is developing the Argo Autonomy Platform, a self-driving platform that will be used by businesses and consumers alike. Argo.ai has partnered with Ford, Lyft, WalMart, and Volkswagen.  Abnormal Security: Let's take a break from self-driving cars and focus on a very hot topic: security in today's IT world. Abnormal focuses on e-mail security, using AI to protect against many attacks such as malware, ransomware, phishing, social engineering, spam, internal account compromise, executive impersonation, supply chain compromise, and graymail. SambaNova: SambaNova is a complete AI solutions provider specializing in big data analytics and machine learning platforms. They incorporate AI-based technology such as Natural Language Processing, High-Resolution Imaging, and Recommendation Systems into their Dataflow-as-a-Service product, designed to transform businesses. DataRobot: Data science is a vast, rapidly growing field, and DataRobot has an automated machine learning platform that helps data scientists build and deploy accurate predictive models quickly and easily. Riskified: Online businesses must deal with fraud every day. Riskified helps e-commerce by using machine learning models that pull from over one billion online transactions to halt fraud attacks, streamline the checkout process, and identify legitimate, genuine shoppers. They count Prada, Ticketmaster, and Trip.com among their customers. Moveworks: Employee retention is a big issue today, considering how the pandemic has caused mass resignations, resulting in many businesses struggling with depleted staff. Moveworks has created an AI platform designed to improve a business's relationship with its staff by offering improved employee support in IT, HR, facilities issues, targeted employee communications, and finance issues. Neuralink: If the idea of self-driving cars sounds like science fiction, wait until the day our brains can directly interface with computers! Neuralink’s mission is to boost the number of channels the brain can use to communicate with technology. Their initial goal is to help people with paralysis easily control computers and mobile devices, giving them more independence. Stem: Energy prices (especially oil) are volatile and can be affected by anything from an oil-rig fire to a worldwide pandemic to an all-out war. Stem uses AI to automate energy cost savings and protect against rate increases. In addition, Stem offers services in many different energy-saving fields such as utility bill optimization, energy storage, sustainability, and commercial EV charging. Are you an AI and Machine Learning enthusiast? If yes, the Post Graduate Program in AI and Machine Learning is a perfect fit for your career growth. Do You Want to Learn About Artificial Intelligence and Machine Learning?

If you’re psyched about the prospect of working for one of these exciting AI startups, but find yourself a bit light in the skills department, don’t worry; Simplilearn has you covered. Simplilearn’s AI and ML Bootcamp, held in collaboration with IBM and CalTech CTME, will make you an AI and ML expert. The bootcamp covers the latest tools and technologies from the AI ecosystem, including masterclasses by Caltech faculty and IBM experts, along with hackathons and Ask Me Anything sessions hosted…

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