Binswanger disease also known as subcortical arteriosclerotic degeneration of the white matter encephalopathy is a progressive neurological chronic, uncontrolled, arterial hypertension disorder caused by arteriosclerosis and thromboembolism affecting the blood vessels that supply the white matter and deep structures of the brain (basal ganglia and thalamus). Most patients experience progressive loss of memory and intellectual abilities (dementia), urinary urgency or incontinence, and an abnormally slow, shuffling, the unsteady pattern of walking, usually over a 5-10 year period. The explanation most often proposed is that chronic arterial hypertension is responsible for the narrowing of the small blood vessels due to lipohyalinosis and fibrosis with subsequent blood flow reduction and hypoxia. Due to their vascular etiology, the symptoms and physical findings associated with Binswanger disease may suddenly worsen due to stroke, stabilize and then improve for a brief time, but the patient’s overall condition continues to progress as the blood vessels become increasingly obstructed. Binswanger’s disease represents one of the causes which lead to vascular cognitive impairment alongside cerebral lacunes, amyloid angiopathy, and some forms of Alzheimer’s disease, and it may coexist with any of these disorders.
Symptoms
Affected individuals often become depressed, uncaring (apathetic), inactive, and unable to act or make decisions (abulic). They become withdrawn and exhibit poor judgment, reduced planning and organizational skills, and less spontaneous communication. In addition, affected individuals may have difficulty with speech (dysarthria), swallowing (dysphagia), and urinary bladder control (incontinence). Some patients exhibit abnormalities that are similar to those seen in Parkinson’s disease, such as slowness, poor balance, and short, shuffling steps (Parkinsonism). Tremor is usually not a feature.
Cognitive and behavioral impairment, motor and gait disturbances, falls, and incontinence evolves with periods of stabilization, plateaus, and periods of improvement. A mixture of pyramidal tract signs, extrapyramidal signs, and pseudobulbar signs can often be seen
Many individuals with Binswanger disease have a history of strokes or transient ischemic attacks. Consequently, the symptoms and signs of this disease develop in a stuttering or stepwise fashion; in contrast to the insidious, gradually progressive course of neurodegenerative diseases.
Causes
Binswanger disease is caused by arteriosclerosis, thromboembolism, and other diseases that obstruct blood vessels that supply the deep structures of the brain. Hypertension, smoking, hypercholesterolemia, heart disease, and insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">diabetes mellitus are risk factors for Binswanger disease. Cognitive and behavioral changes are characterized by dementia and a dysexecutive syndrome (changes in attentional control, working memory, and short‐term memory, impulse control, and abulia in the final stages). Rare hereditary diseases such as CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) also cause Binswanger disease. Thus, Binswanger disease is a clinical syndrome of vascular dementia with multiple causes, not a specific disease. The reduced blood flow in brain tissue appears to produce secondary infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation that may be a target for treatment.
Diagnosis
The diagnosis of Binswanger disease is usually based on a thorough clinical evaluation, including detailed patient history, physical examination, and magnetic resonance imaging (MRI) or computerized tomography (CT) scanning of the brain. MRI and CT reveal nerve fiber (white matter) degeneration and multiple small strokes in the deep structures of the brain.
The neurological examination showed the following:
- Pyramidal tract signs are characterized by hemiparesis regarding the right limbs with a score of 4/5 (on the MRC—Modified Research Council scale). Extensor plantar reflex was objectified in the right leg. The patient also had central face palsy on the same side.
- Extrapyramidal signs are characterized by slowness, left upper limb rigidity, hypomimia, and a low‐volume, monotonous speech.
- Mild cognitive impairment on MMSE testing (a score of 27/30) and on MOCA testing (25/30). The abilities affected in our patient were visuospatial/executive functions, short‐term memory, and mathematical functions.
Treatment
The ischemic brain damage in Binswanger disease is not reversible, so treatment is focused on reducing risk factors for stroke, thereby retarding the progression of the disease. Treatment usually involves the use of anti-hypertensive drugs to control blood pressure, antiplatelet drugs (e.g., aspirin) or warfarin to reduce thromboembolism, statins to reduce atherosclerosis, smoking cessation, and insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">diabetes control. Antidepressant drugs are helpful in the management of depression associated with Binswanger disease. Another treatment is symptomatic and supportive.
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