Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.
Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.
Mechanisms of Action of Eperisone
Mechanisms of action of eperisone on isolated dog saphenous arteries and veins. Eperisonerelaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2 alpha.of eperisone on isolated dog saphenous arteries and veins. Eperisonerelaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2 alpha.
Indications of Eperisone
- Spastic paralysis in conditions such as cerebrovascular disease
- Spastic spinal paralysis
- Cervical spondylosis
- Postoperative sequelae (including from cerebrospinal tumour)
- Sequelae to trauma (e.g. spinal trauma or head injury)
- Amyotrophic lateral sclerosis
- Cerebral palsy
- Spinocerebellar degeneration
- Spinal vascular diseases and other encephalomyelopathies
- Cervical syndrome, periarthritis of the shoulder, and lumbago
- Skeletal muscle relaxation
- Relaxation of hypertonic skeletal muscles
- Improves intramuscular blood flow
- Suppression of spinal reflex potentials
- Reduction of muscle spindle sensitivity via motor neurons
- Vasodilatation and augmentation of blood flow
- Analgesic action and inhibition of the pain reflex in the spinal cord
Contra Indications of Eperisone
Eperisone is contraindicated in patients with known hypersensitivity to the drug.Side effects: ‘very rare’ excessive relaxation, stomachache, nausea, vertigo, anorexia, drowsiness, skin rashes, diarrhoea, vomiting, indigestion, GI disturbances, insomnia, headache, constipation etc.
Dosage of Eperisone
Strengths : 50 mg, 100 mg
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
Adult Dosage |
||||
| 50 mg | 50 (50) | 8 hourly | PO | |
Paedriatic Dosage (20kg) |
||||
| Not recommended in this age group | ||||
Neonatal Dosage (3kg) |
||||
| Not recommended in this age group | ||||
Side Effects of Eperisone
The most common
-
Stevens-Johnson Syndrome
-
Central Nervous System : Weakness, dizziness, sleeplessness, drowsiness, numbness or trembling in the extremities.
-
Miscellaneous : Liver, kidney dysfunction; changes in blood counts, skin rashes, itching, gastrointestinal disturbances and urinary disorders.
Rare
Weakness, dizziness, insomnia, drowsiness, numbness or trembling in the extremities, hepatic and renal dysfunction, haematological changes, skin rashes, itching, GI disturbances, urinary disorders, Rarely, shock.
Drug Interactions of Eperisone
Whenever you take more than one medicine, or mix it with certain foods or beverages, you’re at risk of a drug interaction.
Interaction with Alcohol
Consumption of alcohol can cause severe and potentially irreversible side effects on the liver when taken along with this medicine.
Instructions
You should avoid consuming alcohol while taking myonal 50 MG Tablet. Symptoms like fever, chills, rashes, joint pain and swelling, excessive weakness, nausea should be immediately reported to the doctor.
Interaction with Medicine
Other adverse reactions
| 5%> ≥0.1% | <0.1% | Incidence unknown | |
| Hepatic | Elevation of AST
(GOT), ALT(GPT) and Al-P, etc. |
||
| Renal | Proteinuria and
Elevation of BUN etc.
|
||
| Hematologic | Anemia | ||
| Hypersensitivity | Rash | Pruritus | erythema exudativum
multiforme |
| Psychoneurologic | Sleepiness, insomnia,
headache and numbness in the extremities
|
Stiffness and tremor
in the extremities |
|
| Gastrointestinal | Nausea/vomiting,
anorexia, stomach discomfort, abdominal pain, diarrhea, constipation and thirst |
Stomatitis and tremor
in the extremities |
|
| Urinary | Urinary retention,
urinary incontinence and the feeling of residual urine |
Pregnancy & Lactation
- Use During Pregnancy eperisone HCl should only be used in pregnant women or women suspected of being pregnant if the expected therapeutic benefits are evaluated to outweigh the possible risk of treatment. The safety of eperisone HCl in pregnant women has not been established.
- Use During Lactation It is advisable to avoid the administration of eperisone HCl to nursing mothers. When eperisone HCl must be used, breast feeding should be discontinued during treatment.
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