Sterile Eosinophilic Pustulosis

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 12 min read
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Sterile Eosinophilic Pustulosis, often referred to as Ofuji's disease, is a rare skin disorder. While this name might sound complicated, we can understand it better by dividing it into three parts: Sterile, Eosinophilic, and Pustulosis. Eosinophils are a type of white blood cell that your...

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Article Summary

Sterile Eosinophilic Pustulosis, often referred to as Ofuji's disease, is a rare skin disorder. While this name might sound complicated, we can understand it better by dividing it into three parts: Sterile, Eosinophilic, and Pustulosis. Eosinophils are a type of white blood cell that your body uses to fight infections. In this condition, they gather under your skin where they're not usually needed, causing some...

Key Takeaways

  • This article explains Causes in simple medical language.
  • This article explains Symptoms in simple medical language.
  • This article explains Diagnosis in simple medical language.
  • This article explains Treatment in simple medical language.
Educational health guideWritten for patient understanding and clinical awareness.
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Emergency safety firstUrgent warning signs are highlighted below.

Seek urgent medical care if you notice

These warning signs are general safety guidance. Local emergency numbers and clinical judgment should always come first.

  • Fever with very low white blood cells or known immune suppression.
  • Unusual bruising, persistent bleeding, black stools, or severe weakness.
  • Shortness of breath, fainting, confusion, or rapidly worsening fatigue.
1

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Use emergency care for severe, sudden, rapidly worsening, or life-threatening symptoms.

2

See a doctor

Book a professional medical evaluation if symptoms persist, worsen, recur often, affect daily activities, or occur in a high-risk patient.

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Learn safely

Use this article to understand possible causes, tests, treatment options, prevention, and questions to ask your clinician.

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Definition

Sterile Eosinophilic Pustulosis, often referred to as Ofuji’s disease, is a rare skin disorder. While this name might sound complicated, we can understand it better by dividing it into three parts: Sterile, Eosinophilic, and Pustulosis. Eosinophils are a type of white blood cell that your body uses to fight infections. In this condition, they gather under your skin where they’re not usually needed, causing some trouble. This part refers to the appearance of tiny, pus-filled blisters or ‘pustules’ on the skin. Put together, Sterile Eosinophilic Pustulosis means a skin disorder where pustules form due to an unusual gathering of eosinophils, but without the presence of any bacterial or fungal infections.

Types

Let’s delve into these types and understand more about this skin condition.

Classic Eosinophilic Pustular Folliculitis (EPF)

The classic type of EPF, also known as Ofuji’s disease, is a rare skin disorder that started in Japan but has since been found worldwide. It typically affects healthy adults and is slightly more common in men. Classic EPF is recognized by its recurring outbreaks of red, itchy bumps, or “pustules,” which often appear in circles or rings on the face, scalp, or trunk. These pustules are filled with a type of white blood cell called eosinophils, hence the name. But don’t worry, these pustules are “sterile,” meaning they’re not caused by an infection or bacteria.

Immunocompromised Type

Immunocompromised EPF is typically seen in individuals with a weakened immune system. This could be due to a range of causes, such as HIV/AIDS, organ transplantation, or chemotherapy. Just like the classic type, it’s also characterized by itchy, red bumps filled with eosinophils. However, the distribution of these pustules can vary, and they often appear on the head, neck, and upper body. Early detection and treatment can prevent the condition from becoming severe and causing additional health problems.

Infantile Type

As the name suggests, the infantile type affects infants, usually within the first few months of life. This type of EPF appears as a rash of itchy, red bumps mainly on the scalp and face. Despite its unsettling appearance, it’s not a dangerous condition, and most infants outgrow it by their first birthday. The cause of EPF is still unknown, and there’s no known cure. However, treatments such as topical creams, light therapy, and oral medications can help manage symptoms and reduce flare-ups.

Causes

Causes, helping you understand the nature of this skin issue in a language that’s easy to follow.

  1. Immunosuppression: When the body’s immune system isn’t working at its best, it can trigger this skin condition. HIV/AIDS patients or organ transplant recipients taking immunosuppressive drugs often face this issue.
  2. Cancer: Some forms of cancer and its treatments, like chemotherapy, can make the body vulnerable to eosinophilic pustular folliculitis.
  3. Medications: Certain drugs, like those used for managing epilepsy or high blood pressure, can cause this condition as a side effect.
  4. Hormonal Changes: Sudden shifts in hormonal balance, especially during pregnancy or puberty, can trigger this skin problem.
  5. Allergies: Allergic reactions to certain substances can lead to sterile eosinophilic pustulosis.
  6. Autoimmune Disorders: Conditions where the body attacks its cells, like lupus, can make someone susceptible to this skin condition.
  7. Stress: Emotional or physical stress can often lead to an outbreak, highlighting the body-mind connection.
  8. Infections: Certain bacterial, viral, or fungal infections can trigger this condition.
  9. Skin Trauma: Physical damage to the skin like burns, wounds, or surgical procedures can be a potential cause.
  10. Genetics: Some individuals might inherit a predisposition to this skin condition from their parents.
  11. Environmental Factors: Exposure to extreme weather conditions or certain chemicals can lead to sterile eosinophilic pustulosis.
  12. Age: While it can affect any age, the condition is more common in adulthood.
  13. Nutritional Deficiency: Lack of essential nutrients like vitamins and minerals can trigger the condition.
  14. Poor Hygiene: Not maintaining proper skin cleanliness can result in this skin problem.
  15. Alcohol Consumption: Excessive drinking can affect the body’s immune system and cause the condition.
  16. Smoking: Similarly, regular smoking can put a person at risk.
  17. Chronic Diseases: Conditions like insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">diabetes or heart disease can increase the chances of having this skin condition.
  18. Obesity: Overweight individuals have an increased risk, possibly due to associated infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation.
  19. Psoriasis: People with psoriasis may develop eosinophilic pustular folliculitis.
  20. Systemic Medications: Some systemic medications, such as interferon or antifungals, can trigger this condition.
  21. Immunoglobulin Disorders: These disorders can cause the immune system to malfunction, leading to sterile eosinophilic pustulosis.
  22. Thyroid Problems: Disorders like thyroid gland makes too much hormone. সহজ বাংলা: থাইরয়েড হরমোন বেশি।" data-rx-term="hyperthyroidism" data-rx-definition="Hyperthyroidism means the thyroid gland makes too much hormone. সহজ বাংলা: থাইরয়েড হরমোন বেশি।">hyperthyroidism or hypothyroidism can cause this skin issue.
  23. Chronic infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">Inflammation: Long-term infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation in the body can lead to the development of this condition.
  24. Hormonal Disorders: Conditions like polycystic ovarian syndrome (PCOS) can trigger the disease.
  25. Insect Bites: Some people develop this skin condition following an insect bite.
  26. Vaccination: Rarely, certain vaccinations might trigger this skin issue as a reaction.
  27. Exposure to Radiation: Individuals exposed to high levels of radiation might develop this condition.
  28. Skin Care Products: Certain skincare products might lead to a reaction, causing this skin condition.
  29. Sun Exposure: Excessive exposure to the sun might result in the development of sterile eosinophilic pustulosis.
  30. Toxins: Exposure to certain environmental toxins could also be a potential cause.

Symptoms

Symptoms to help you recognize this condition better. Let’s take a closer look at each symptom.

  1. Itchy Skin: This is the most common symptom of SEP. The skin around the rash often feels irritatingly itchy, making you want to scratch it continuously.
  2. Redness: The skin around the blisters becomes red. This redness is due to infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation, a natural response of your body to any irritant.
  3. Swelling: Another symptom of SEP is skin swelling. This happens because your body is trying to fight off what it thinks is an infection.
  4. Pus-filled Blisters: Blisters filled with pus are the defining characteristic of SEP. However, unlike other types of pustules, these do not contain harmful bacteria.
  5. Clustered Blisters: The blisters usually come in clusters. They are tightly packed together, often forming a circular or oval shape.
  6. Peeling Skin: As the blisters heal, the skin on top might start to peel off. This is a normal part of the healing process.
  7. Skin Tenderness: The skin around and under the blisters tends to be sensitive or tender to touch.
  8. Mild Fever: Some people may experience a slight increase in body temperature or mild fever.
  9. Burning Sensation: SEP can sometimes cause a burning sensation, making the affected skin feel uncomfortably hot.
  10. Skin Discoloration: After the blisters heal, they might leave behind patches of skin that are a different color. These can be lighter or darker than your natural skin tone.
  11. Fatigue: This condition can also cause a feeling of tiredness or fatigue. That’s because your body is working hard to repair your skin.
  12. Painful Blisters: While not always the case, some people might find the blisters to be painful, especially when touched or rubbed against clothing.
  13. Localized Rash: SEP usually occurs in a specific area rather than all over the body. Commonly affected areas include the face and upper body.
  14. Dry Skin: The skin around the blisters might become dry and scaly.
  15. Fluid Leakage: Sometimes, the blisters might burst open, releasing a clear fluid.
  16. Slow Healing: The healing process of SEP can be slow, with new blisters forming as old ones heal.
  17. Flare-ups: SEP is known for recurring flare-ups, meaning the symptoms can go away and then come back again.
  18. Chills: In some cases, individuals might experience chills or cold sweats, although this is less common.
  19. Stinging Sensation: Some people report a stinging sensation, similar to a mild sunburn.
  20. Discomfort: Lastly, general discomfort or unease is commonly associated with this condition due to the physical symptoms it presents.

Diagnosis

Diagnosis and tests used to identify this condition in a simple, user-friendly way.

  1. Clinical History: Doctors begin by understanding your medical history, any recurrent rashes, itching, or other skin conditions you’ve experienced.
  2. Physical Examination: A doctor will check your skin, looking for characteristic signs such as pustules or circular patterns of skin irritation.
  3. Skin Biopsy: A small sample of your skin is taken and checked under a microscope. If eosinophils are present, it could be sterile eosinophilic pustulosis.
  4. Complete Blood Count (CBC): This blood test checks if you have more eosinophils than usual, a clue that might point to this condition.
  5. Eosinophil Count: Specifically counting eosinophils can confirm if they are unusually high.
  6. Direct Immunofluorescence (DIF): This test checks for immune cells in your skin sample, which can reveal inflammation or other signs of this condition.
  7. Dermoscopy: A special magnifying tool called a dermoscope helps doctors see the skin more clearly, making it easier to spot the signs of sterile eosinophilic pustulosis.
  8. Allergy Testing: This can rule out other causes of skin reactions like allergies.
  9. Patch Testing: This checks for contact dermatitis, another skin condition that can look similar to sterile eosinophilic pustulosis.
  10. Fungal Culture: Checks if a fungus is causing your skin condition.
  11. Bacterial Culture: It rules out bacterial infections, as pustules could also be caused by bacteria.
  12. Parasite Test: Rules out parasites as the cause of the skin condition.
  13. Autoantibody Testing: This test checks for autoimmune conditions that can cause skin problems.
  14. Immunoglobulin Test: A test to measure immune response and inflammation, which can indicate this condition.
  15. Pustule Aspiration and Examination: The fluid inside the pustule is checked for eosinophils.
  16. C-reactive Protein Test: A blood test to check for signs of inflammation in the body.
  17. Imaging Tests: Sometimes, imaging tests like an X-ray or MRI are used to look for inflammation in the body.
  18. HIV Test: Some skin conditions can be associated with immune suppression, like HIV.
  19. Serum Electrolytes: This blood test checks your body’s balance of minerals, which could be disturbed in some skin conditions.
  20. Liver Function Test: To rule out liver diseases that may cause skin symptoms.
  21. Kidney Function Test: To check if any kidney problems are causing skin symptoms.
  22. Thyroid Function Test: To rule out thyroid diseases, which can also cause skin conditions.
  23. Chest X-Ray: Sometimes, lung diseases can cause skin problems. A chest X-ray can rule this out.
  24. Antinuclear Antibody (ANA) Test: This checks for autoimmune diseases that could cause skin symptoms.
  25. Erythrocyte Sedimentation Rate (ESR): Measures inflammation levels in the body.
  26. Serum Protein Electrophoresis: This test can reveal abnormal proteins in the blood, which could suggest certain diseases.
  27. D-xylose Absorption Test: A test to check if your body is absorbing nutrients properly.
  28. Serum Calcium: High calcium levels can sometimes cause skin symptoms.
  29. Lactate Dehydrogenase Test: High levels can indicate tissue damage, including skin.
  30. Consultation with a Dermatologist: An expert in skin conditions can confirm the diagnosis and recommend treatment.

Treatment

It’s often characterized by itchy, red bumps, or blisters (known as pustules) filled with a type of white blood cell called eosinophils. But no need to worry, this guide will navigate you through the top treatments that can help manage SEP.

1. Topical Corticosteroids: These are creams or ointments you rub onto your skin. They reduce inflammation, and itching, and help the skin heal.

2. Systemic Corticosteroids: These are pills that you swallow. They also lower inflammation but for the whole body.

3. Topical Tacrolimus: This is a cream that can ease inflammation and help the skin heal.

4. Indomethacin: A kind of medicine called a nonsteroidal anti-inflammatory drug (NSAID). It can ease pain and inflammation.

5. Dapsone: This medicine helps fight inflammation. It can also kill bacteria and parasites, though SEP isn’t caused by those.

6. Phototherapy: Using light (often ultraviolet) to treat skin conditions.

7. Colchicine: A medicine that can decrease inflammation.

8. Cyclosporine: A medicine that suppresses the immune system to reduce inflammation.

9. Potassium Iodide: It’s often used for skin conditions like SEP.

10. Isotretinoin: A powerful medicine for severe skin conditions.

11. Methotrexate: A medicine that can help control the immune system and reduce inflammation.

12. Azathioprine: Another immune-suppressing medicine.

13. Cyclophosphamide: This is a strong medicine that can suppress the immune system.

14. Psoralen Plus Ultraviolet A (PUVA): A type of phototherapy combining a medicine called Psoralen and ultraviolet A light.

15. Mycophenolate Mofetil: A medicine that can suppress the immune system.

16. Oral Retinoids: These medicines can help with severe skin conditions.

17. Minocycline: A type of antibiotic that can also fight inflammation.

18. Antihistamines: These can help with itching.

19. Intravenous Immunoglobulins (IVIG): These are proteins that can help the immune system.

20. Erythromycin: This is an antibiotic that can also fight inflammation.

21. Hydroxychloroquine: A medicine often used for autoimmune conditions.

22. Topical Calcineurin Inhibitors: These creams or ointments can reduce inflammation.

23. Biological Treatments: These use substances from living organisms to treat conditions.

24. Coal Tar: A thick, black liquid used in creams and shampoos that can help with skin conditions.

25. Selenium Sulfide: An ingredient in some shampoos that can help with skin conditions.

26. Zinc Pyrithione: Another ingredient in shampoos that can help with skin conditions.

27. Interferon Therapy: This uses substances the body naturally makes to boost the immune system.

28. Pimecrolimus: A type of cream that can reduce inflammation.

29. Ketoconazole: An antifungal that can also help with inflammation.

30. Salicylic Acid: An ingredient in some creams and shampoos that can help with skin conditions.

It’s crucial to remember that everyone is different. A treatment that works for one person might not work for another. Always talk to your doctor before starting any new treatment. They can help you weigh the benefits and risks and choose the best option for you.

By choosing a path that best fits your needs, you’re on your way to overcoming Sterile Eosinophilic Pustulosis. With this list of 30 treatments, you’ve got a comprehensive understanding of your options. Keep exploring and discussing with your healthcare provider, and soon you will find a method that works best for you. Stay hopeful, because help is always around the corner.

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Doctor visit helper

Prepare before seeing a doctor

A simple rural-patient checklist to help you explain symptoms clearly, ask better questions, and avoid unsafe self-treatment.

Safety note: This is not a prescription or diagnosis. For severe symptoms, pregnancy danger signs, children with serious illness, chest pain, breathing difficulty, stroke-like weakness, or major injury, seek urgent care.

Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
  • Bring old prescriptions, investigation reports, and current medicines.
  • Write allergies, pregnancy status, diabetes, kidney/liver disease, and major past illnesses.
  • Bring one family member if the patient is weak, elderly, confused, or a child.

Questions to ask

  • What is the most likely cause of my symptoms?
  • Which danger signs mean I should go to hospital quickly?
  • Which tests are necessary now, and which can wait?
  • How should I take medicines safely and what side effects should I watch for?
  • When should I come for follow-up?

Tests to discuss

  • Vital signs: temperature, pulse, blood pressure, oxygen saturation
  • Basic physical examination by a clinician
  • CBC, urine test, blood sugar, or imaging only when clinically needed

Avoid these mistakes

  • Do not use antibiotics, steroid tablets/injections, or strong painkillers without proper medical advice.
  • Do not hide pregnancy, kidney disease, ulcer, allergy, or blood thinner use.
  • Do not delay emergency care when danger signs are present.

Medicine safety and first-aid guide

This section is for patient education only. It does not replace a doctor, pharmacist, or emergency care.

Safe first steps

  • Avoid heavy lifting, sudden bending, and prolonged bed rest.
  • Use comfortable posture and gentle movement as tolerated.
  • Discuss physiotherapy, X-ray, or MRI only when clinically needed.

OTC medicine safety

  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
  • Avoid repeated painkiller use if you have kidney disease, stomach ulcer, uncontrolled blood pressure, or are taking blood thinners.

Avoid these mistakes

  • Do not start antibiotics without a proper medical decision.
  • Do not use steroid tablets or injections casually for quick relief.
  • Do not delay emergency care because of home remedies.

Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
Medicine names, dose, and timing must be decided by a qualified clinician or pharmacist after checking age, pregnancy, allergy, other diseases, and current medicines.

For rural patients and family caregivers

Patient health record and symptom diary

Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Medicine doctor / pediatrician for children / qualified clinician
Tests to discuss with doctor
  • Temperature chart and hydration assessment
  • CBC with platelet count if fever persists or dengue/other infection is possible
  • Urine test, malaria/dengue tests, chest evaluation, or blood culture only when clinically indicated
Questions to ask
  • What is the most likely cause of my symptoms?
  • Which warning signs mean I should go to emergency care?
  • Which tests are really needed now?
  • Which medicines are safe for my age, pregnancy status, allergy, kidney/liver/stomach condition, and current medicines?
  • Do I need antibiotics, or is this more likely viral?

Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Sterile Eosinophilic Pustulosis

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
  • Ask which warning signs mean urgent referral to hospital.

This roadmap is for education. A real diagnosis and treatment plan requires history, examination, and clinical judgment.

RX Patient Help

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Write your symptom story. A health professional or site editor can review it before any answer is prepared. This box is not for emergency care.

Emergency first: Severe chest pain, breathing trouble, unconsciousness, stroke signs, severe injury, heavy bleeding, or rapidly worsening symptoms need urgent local medical care now.

Frequently Asked Questions

Is this article a replacement for a doctor?

No. It is educational content only. Patients should consult a qualified clinician for diagnosis and treatment.

When should I seek urgent care?

Seek urgent care for severe symptoms, rapidly worsening condition, breathing difficulty, severe pain, neurological changes, or any emergency warning sign.

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