Epithelioid Hemangioendothelioma

Last updated: February 8, 2026Reviewed date: February 8, 2026Reading time: 13 min read
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Epithelioid hemangioendothelioma is a rare form of cancer that originates in the cells of the blood vessels. It is classified as an intermediate-grade tumor, meaning that it is not as aggressive as high-grade tumors but is still more dangerous than low-grade tumors. Epithelioid hemangioendothelioma can...

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Article Summary

Epithelioid hemangioendothelioma is a rare form of cancer that originates in the cells of the blood vessels. It is classified as an intermediate-grade tumor, meaning that it is not as aggressive as high-grade tumors but is still more dangerous than low-grade tumors. Epithelioid hemangioendothelioma can occur in any part of the body but is most commonly found in the liver, lungs, and bones. The tumor...

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Definition

Epithelioid hemangioendothelioma is a rare form of cancer that originates in the cells of the blood vessels. It is classified as an intermediate-grade tumor, meaning that it is not as aggressive as high-grade tumors but is still more dangerous than low-grade tumors.

Epithelioid hemangioendothelioma can occur in any part of the body but is most commonly found in the liver, lungs, and bones. The tumor is made up of epithelioid cells, which are cells that resemble those found in the lining of organs such as the lungs or intestines.

Epithelioid hemangioendothelioma (EHE) is a rare form of cancer that develops from the lining of blood vessels. EHE can occur in any part of the body, but it is most commonly found in the liver, lungs, and bones. The cancer is composed of cells that have a unique appearance, with a mixture of characteristics of both epithelial and endothelial cells. The tumor can be benign or malignant, and the behavior of the tumor can vary greatly depending on its location.

Types

There are several types of EHE that have been identified based on their location and behavior. These include:

  1. Hepatic epithelioid hemangioendothelioma: This type of EHE occurs in the liver and is the most common type. It can be difficult to diagnose because it often presents with nonspecific symptoms such as abdominal pain, nausea, and fatigue.
  2. Pulmonary epithelioid hemangioendothelioma: This type of EHE occurs in the lungs and is typically slow-growing. It often presents with symptoms such as cough, shortness of breath, and chest pain.
  3. Osseous epithelioid hemangioendothelioma: This type of EHE occurs in the bones and is also slow-growing. It can present with symptoms such as bone pain, swelling, and fractures.
  4. Soft tissue epithelioid hemangioendothelioma: This type of EHE occurs in soft tissues such as muscle or fat. It is also slow-growing and can present with symptoms such as pain or swelling in the affected area.

Causes

While the exact cause of EHE is not fully understood, researchers have identified several risk factors that may increase the likelihood of developing the disease.

Here are the possible causes of EHE:

  1. Genetic mutations: EHE may be caused by genetic mutations that affect the regulation of cell growth and division.
  2. Environmental toxins: Exposure to certain environmental toxins, such as asbestos and vinyl chloride, may increase the risk of developing EHE.
  3. Radiation exposure: Radiation therapy for other cancers may increase the risk of developing EHE.
  4. Infection: In some cases, EHE may be caused by infection with certain viruses, such as the human herpesvirus-8.
  5. Autoimmune disorders: People with certain autoimmune disorders, such as lupus and pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।" data-rx-term="arthritis" data-rx-definition="Arthritis means joint inflammation causing pain, swelling, stiffness, or reduced movement. সহজ বাংলা: জয়েন্টের প্রদাহ।">arthritis: Rheumatoid arthritis is an autoimmune joint disease causing infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation, pain, and swelling. সহজ বাংলা: রোগপ্রতিরোধ ব্যবস্থার ভুল আক্রমণে জয়েন্টের প্রদাহ।" data-rx-term="rheumatoid arthritis" data-rx-definition="Rheumatoid arthritis is an autoimmune joint disease causing inflammation, pain, and swelling. সহজ বাংলা: রোগপ্রতিরোধ ব্যবস্থার ভুল আক্রমণে জয়েন্টের প্রদাহ।">rheumatoid arthritis, may have a higher risk of developing EHE.
  6. Hormonal imbalances: Hormonal imbalances, such as those that occur during pregnancy, may increase the risk of developing EHE.
  7. Age: EHE is most commonly diagnosed in middle-aged adults, but can occur at any age.
  8. Gender: EHE occurs slightly more frequently in women than men.
  9. Race: EHE occurs more frequently in white people than other racial groups.
  10. Family history: Having a family history of EHE or other types of cancer may increase the risk of developing the disease.
  11. Smoking: Smoking may increase the risk of developing EHE, particularly in the lungs.
  12. Alcohol consumption: Heavy alcohol consumption may increase the risk of developing liver EHE.
  13. Obesity: Obesity may increase the risk of developing liver EHE.
  14. insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।" data-rx-term="diabetes" data-rx-definition="Diabetes is a condition where blood sugar stays too high because insulin is low or not working well. সহজ বাংলা: রক্তে চিনি বেশি থাকার রোগ।">Diabetes: People with diabetes may have a higher risk of developing liver EHE.
  15. Liver disease: People with pre-existing liver disease, such as cirrhosis, may have a higher risk of developing liver EHE.
  16. Bone fractures: EHE may develop in bone fractures that have not healed properly.
  17. Surgical implants: EHE may develop around surgical implants, such as joint replacements.
  18. Chronic infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।" data-rx-term="inflammation" data-rx-definition="Inflammation is the body’s response to injury, infection, or irritation, often causing pain, swelling, heat, or redness. সহজ বাংলা: শরীরের প্রদাহ; ব্যথা, ফোলা বা লালভাব হতে পারে।">inflammation: Chronic inflammation in the body may increase the risk of developing EHE.
  19. Immunosuppression: People who have weakened immune systems, such as those with HIV/AIDS or who are taking immunosuppressive medications, may have a higher risk of developing EHE.
  20. Unknown factors: In many cases, the cause of EHE is unknown.

While the exact cause of EHE is not fully understood, it is clear that certain risk factors may increase the likelihood of developing the disease. Understanding these risk factors can help doctors identify people who may be at higher risk and take steps to monitor and treat the disease early on. If you are concerned about your risk of developing EHE, talk to your doctor about any relevant medical history or lifestyle factors that may increase your risk. Early detection and treatment can significantly improve outcomes for people with EHE.

Symptoms

While the symptoms of EHE can vary depending on the location of the cancer, there are some common signs that people with this condition may experience and symptoms of EHE in detail, along with their possible causes and treatment options.

  1. Fatigue – Fatigue is a common symptom of EHE. It may be caused by the cancer itself or by the body’s immune response to the cancer. The cancer can also cause anemia, which can lead to fatigue.
  2. Weight loss – Weight loss is another common symptom of EHE. It can be caused by the cancer’s effect on the body’s metabolism or by a loss of appetite.
  3. Abdominal pain – EHE in the liver can cause abdominal pain. The pain may be dull or sharp and may be accompanied by swelling or tenderness in the abdomen.
  4. Nausea and vomiting – EHE in the liver can also cause nausea and vomiting. These symptoms may be due to the cancer’s effect on the digestive system.
  5. Jaundice – Jaundice is a yellowing of the skin and eyes that can occur when EHE affects the liver. It is caused by a buildup of bilirubin, a substance produced by the liver.
  6. Shortness of breath – EHE in the lungs can cause shortness of breath. This may be due to a buildup of fluid in the lungs or to the cancer’s effect on the lungs’ ability to function properly.
  7. Chest pain – Chest pain is another symptom of EHE in the lungs. The pain may be sharp or dull and may be accompanied by difficulty breathing.
  8. Coughing – Coughing is another symptom of EHE in the lungs. The cough may be dry or productive and may be accompanied by shortness of breath.
  9. Bone pain – EHE that affects the bones can cause bone pain. The pain may be localized or spread throughout the body.
  10. Fractures – EHE that affects the bones can also lead to fractures. This is because the cancer can weaken the bones, making them more susceptible to breaking.
  11. Skin lesions – EHE that affects the skin can cause the development of lesions. The lesions may be red, purple, or brown and may be raised or flat.
  12. Skin discoloration – EHE that affects the skin can also cause discoloration. The affected area may be lighter or darker than the surrounding skin.
  13. Swelling – EHE can cause swelling in the affected area. This may be due to the cancer’s effect on the lymphatic system or to a buildup of fluid.
  14. Fever – Fever is a common symptom of EHE. It may be caused by the body’s immune response to the cancer.
  15. Night sweats – Night sweats are another common symptom of EHE. They may be caused by the body’s immune response to the cancer or by the cancer’s effect on the body’s metabolism.
  16. Headaches – EHE that affects the brain can cause headaches. The headaches may be mild or severe and may be accompanied by other neurological symptoms.
  17. Seizures – EHE that affects the brain can also cause seizures. Seizures may be partial or generalized and may be accompanied by other neurological symptoms.
  18. Vision changes – EHE that affects the eye or the optic nerve can cause changes in vision. This may include blurred vision, double vision, or loss of vision.

Diagnosis

The diagnosis of EHE can be challenging, as it shares many features with other types of tumors. Here are 20 common tests and diagnoses that can be used to identify EHE.

  1. Imaging tests – Imaging tests such as CT scans, MRI scans, and ultrasound can be used to detect the presence and location of the tumor.
  2. Biopsy – A biopsy involves removing a small sample of tissue from the tumor and examining it under a microscope. This can help to confirm the diagnosis of EHE and rule out other types of tumors.
  3. Histopathology – Histopathology is the study of tissue samples under a microscope to identify the type of cells and tissues present. This can help to confirm the diagnosis of EHE and determine the severity of the tumor.
  4. Immunohistochemistry – Immunohistochemistry is a technique used to identify specific proteins and molecules in tissue samples. It can be used to confirm the diagnosis of EHE and rule out other types of tumors.
  5. Molecular testing – Molecular testing involves analyzing the DNA or RNA of the tumor cells. It can be used to identify genetic mutations that are associated with EHE and to guide treatment decisions.
  6. Blood tests – Blood tests can be used to assess liver and kidney function and to detect abnormalities that may be associated with EHE.
  7. Liver function tests – Liver function tests can be used to assess the function of the liver and detect abnormalities that may be associated with liver involvement in EHE.
  8. Biopsy of liver – If the tumor is located in the liver, a biopsy of the liver may be needed to confirm the diagnosis of EHE and determine the severity of the tumor.
  9. Pulmonary function tests – Pulmonary function tests can be used to assess lung function and detect abnormalities that may be associated with lung involvement in EHE.
  10. Bronchoscopy – If the tumor is located in the lungs, a bronchoscopy may be needed to visualize the airways and collect tissue samples for analysis.
  11. PET scan – A PET scan is a type of imaging test that uses radioactive tracers to detect metabolic activity in the body. It can be used to detect the presence and location of the tumor and to monitor the effectiveness of treatment.
  12. Bone scan – A bone scan is a type of imaging test that uses radioactive tracers to detect abnormalities in the bones. It can be used to detect bone involvement in EHE.
  13. CT-guided biopsy – If the tumor is located in a deep or hard-to-reach area, a CT-guided biopsy may be needed to collect tissue samples for analysis.
  14. MRI-guided biopsy – Similar to CT-guided biopsy, an MRI-guided biopsy may be needed if the tumor is located in a hard-to-reach area.
  15. Angiogram – An angiogram is a type of imaging test that uses contrast dye to visualize the blood vessels. It can be used to detect abnormalities in the blood vessels that may be associated with EHE.
  16. Endoscopy – An endoscopy is a procedure that involves inserting a small, flexible tube with a camera into the body. It can be used to visualize the inside of the digestive tract and collect tissue samples for analysis.
  17. Laparoscopy – Laparoscopy is a minimally invasive surgical procedure that involves inserting a small camera into the body to visualize the organs and collect tissue samples for analysis.
  18. X-ray – X-rays can be used to detect abnormalities in the bones and other tissues.
  19. Fine needle aspiration – Fine needle aspiration is a procedure

Treatment

As EHE is a rare cancer, there is no standard treatment protocol for it. However, several treatments are available to manage EHE, which can vary depending on the location and stage of the cancer and treatments for EHE, their details, and how they can help manage EHE.

  1. Surgery: Surgery is the most common treatment for EHE. It involves removing the tumor and any affected tissue or organ. Surgery is often the first-line treatment for localized EHE.
  2. Radiation therapy: Radiation therapy uses high-energy radiation to kill cancer cells. It can be used as a primary treatment or in combination with surgery. Radiation therapy is often used for unresectable EHE or as an adjuvant therapy to prevent cancer recurrence.
  3. Chemotherapy: Chemotherapy uses drugs to kill cancer cells. It is not a standard treatment for EHE, but it can be used in certain cases where the cancer has spread to other parts of the body.
  4. Targeted therapy: Targeted therapy is a type of cancer treatment that uses drugs to target specific genes, proteins, or other molecules involved in cancer growth and survival. It is an emerging treatment option for EHE.
  5. Immunotherapy: Immunotherapy uses the body’s immune system to fight cancer. It can be used as a standalone treatment or in combination with other therapies.
  6. Radiofrequency ablation (RFA): RFA is a minimally invasive procedure that uses heat generated by high-frequency electrical currents to destroy cancer cells. It is often used for small tumors that are not suitable for surgery.
  7. Cryoablation: Cryoablation is a minimally invasive procedure that uses extreme cold to freeze and destroy cancer cells. It is also used for small tumors that are not suitable for surgery.
  8. Transarterial chemoembolization (TACE): TACE is a minimally invasive procedure that combines chemotherapy and embolization to treat liver cancer. It can also be used to treat liver metastases from EHE.
  9. Embolization: Embolization is a minimally invasive procedure that blocks blood vessels to starve cancer cells of oxygen and nutrients. It is often used in combination with other therapies.
  10. Hepatic artery infusion (HAI): HAI is a targeted therapy that delivers chemotherapy directly to the liver through a catheter placed in the hepatic artery. It is used to treat liver cancer and liver metastases from EHE.
  11. Sorafenib: Sorafenib is a targeted therapy that inhibits multiple protein kinases involved in cancer growth and survival. It is approved for the treatment of advanced liver cancer and can be used off-label for EHE.
  12. Pazopanib: Pazopanib is a targeted therapy that inhibits multiple protein kinases involved in cancer growth and survival. It is approved for the treatment of advanced soft tissue sarcoma and can be used off-label for EHE.
  13. Bevacizumab: Bevacizumab is a targeted therapy that inhibits the growth of blood vessels that supply cancer cells. It is approved for the treatment of various cancers, including colorectal cancer, lung cancer, and renal cell carcinoma, and can be used off-label for EHE.
  14. Sunitinib: Sunitinib is a targeted therapy that inhibits multiple protein kinases involved in cancer growth and survival. It is approved for the treatment of gastrointestinal stromal tumors and advanced renal cell carcinoma and can be used

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Which doctor may help?

Start with a registered doctor or the nearest qualified health center.

What to tell the doctor

  • Write when the problem started and how it changed.
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Questions to ask

  • What is the most likely cause of my symptoms?
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Tests to discuss

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Safe first steps

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  • For mild back pain, pain-relief medicine may be discussed with a doctor or pharmacist.
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  • Do not start antibiotics without a proper medical decision.
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Get urgent help if

  • Back pain with leg weakness, numbness around private area, loss of urine/stool control, fever, cancer history, or major injury needs urgent care.
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Write your symptoms, medicines already taken, test results, and questions before visiting a doctor. This note stays on your device unless you print or copy it.

Doctor to discuss: Medicine doctor / pediatrician for children / qualified clinician
Tests to discuss with doctor
  • Temperature chart and hydration assessment
  • CBC with platelet count if fever persists or dengue/other infection is possible
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Questions to ask
  • What is the most likely cause of my symptoms?
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Emergency warning signs such as chest pain, severe breathing difficulty, sudden weakness, confusion, severe dehydration, major injury, or loss of bladder/bowel control need urgent medical care. Do not wait for online information.

Safe pathway to proper treatment

Care roadmap for: Epithelioid Hemangioendothelioma

Use this simple roadmap to understand the next safe steps. It is educational and does not replace examination by a doctor.

Go to emergency care if you notice:
  • Severe or rapidly worsening symptoms
  • Breathing difficulty, chest pain, fainting, confusion, severe weakness, major injury, or severe dehydration
Doctor / service to discuss: Qualified healthcare provider; specialist depends on symptoms and examination.
  1. Step 1

    Check danger signs first

    If danger signs are present, seek emergency care and do not wait for online information.

  2. Step 2

    Record the symptom story

    Write when symptoms started, severity, medicines already taken, allergies, pregnancy status, and test results.

  3. Step 3

    Visit a qualified clinician

    A doctor, nurse, or qualified healthcare provider can examine you and decide which tests or treatment are needed.

  4. Step 4

    Do only useful tests

    Do tests after clinical assessment. Avoid unnecessary tests, random antibiotics, or repeated medicines without diagnosis.

  5. Step 5

    Follow up and return early if worse

    If symptoms worsen, new warning signs appear, or treatment is not helping, return for review quickly.

Rural patient practical tips
  • Take a written symptom diary and all previous prescriptions/test reports.
  • Do not hide medicines already taken, even herbal or over-the-counter medicines.
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Composite Hemangioendothelioma

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