Indications of AceclofenacAceclofenac ContraindicationsDosage of Aceclofenac Side Effects of AceclofenacDrug Interactions of AceclofenacPregnancy& Lactation of AceclofenacAceclofenac Contraindications/ Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studiesAceclofenac potently inhibits the cyclooxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility. It displays high permeability to penetrate into synovial joints wherein patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation.Aceclofenac belongs to the class of non-steroidal anti-inflammatory preparations for topical use. Used in the treatment of joint and muscular pains due to it muscle relaxing action.Indications of AceclofenacAceclofenac tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions, and symptomsIndicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.Muscles stiffness in spinalMuscles stiffness in muscle diseasesMuscles stiffness in the joint diseasesLumbagoLow back painPLIDFrozen shoulderAnkylosing spondylitisPain caused by nonarticular rheumatismMuscles stiffness in nerve diseasesRheumatoid arthritisOsteoarthritisCervical spondylosisPeriarthritis of scapulohumeralIschiadyniaa backacheTeethingAceclofenac ContraindicationsHypersensitivity to Aceclofenac Tablet is a contraindication. In addition, Aceclofenac Tablet should not be used if you have the following conditionsActive peptic ulcerAcute rhinitisAllergic to thiocolchicosideAsthmaBreastfeedingPregnantUrticariaConcurrent peptic ulcer, or history of ulcer diseaseAllergy to indomethacin, aspirin, or other NSAIDsPatients with nasal polyps reacting with angioedema to other NSAIDsChildren under 2 years of age (with the exception of neonates with patent ductus arteriosus)Some painkillers, including opioid pain killers;Hypnotic drugs;Psychotropic drugs;Used monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromineEpilepsy;Addiction or are recovering from addiction to another medication.History of peptic ulcer disease,Gastrointestinal bleeding,Severe pre-existing renal and liver damageCaution: pre-existing bone marrow damage (frequent blood cell counts are indicated)Caution: bleeding tendencies of unknown originCaution: Parkinson’s disease, epilepsy, psychotic disorders (indometacin may worsen these conditions)Concurrent with potassium sparing diureticsPatients who have a patent ductus arteriosus dependent heart defect (such as transposition of the great vessels)Significant hypertension (high blood pressure)Concomitant administration of lithium salts (such as lithium carbonate)Dosage of Aceclofenac Strengths : 100 mg , 200 mgAnkylosing spondylitis100 mg bid, in the morning and in the evening.Rheumatoid arthritis100 mg bid, in the morning and in the evening.Osteoarthritis100 mg bid, in the morning and in the evening.Side Effects of AceclofenacThe most commonGI disorders (e.g. dyspepsia, abdominal pain, nausea, vomiting, diarrhea, flatulence, constipation,, ulcerative stomatitis, ), indigestion,Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain.Drowsiness and lightheadednessNausea and vomitingjoint painNausea and vomitingSevere stomach acheSevere diarrheaVaginal thrushSkin rashHeadacheChest painDiarrhea or loose stoolsDifficulty with breathingDizzinessHeartburnMuscle painMore commonAbdominal or stomach pain,Chills or feverHeadache,Joint or back painMuscle aching or crampingMuscle pains or stiffnessChest pressure or squeezing pain in the chestExcessive sweatingfeeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvissudden tingling or coldness in an arm or legConstipationDiarrhoeaLoss of muscle coordinationSleepiness or unusual drowsinessClumsiness or unsteadinessDrowsinessRareAnxietychange in visionseizuresabnormal or fast heart rateweight losschest pain or tightnessconfusiona coughAgitationarm, back, or jaw painblurred visionchest pain or discomfortconvulsionsextra heartbeats, faintingblurred visionchest pain or discomfortconvulsionsextra heartbeatshallucinationsa headacheirritabilitylightheadednessmood or mental changesmuscle pain or crampsmuscle spasm or jerking of all extremitiesmuscle pains or stiffnesschest pressure or squeezing pain in the chestdiscomfort in arms, shoulders, neck or upper backpain or discomfort in the chest, upper stomach, or throatpale or blue lips, fingernails, or skinpuffiness or swelling of the eyelids or around the eyes, face, lips, or tongueunusual drowsiness, dullness, or feeling of sluggishnessDrug Interactions of AceclofenacAceclofenac may interact with following drugs, supplements & may change the efficacy of drugsantacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)bisphosphonates (e.g., alendronate, etidronate, risedronate, zoledronic acid)antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)angiotensin-converting enzyme inhibitors (ACEIs; e.g., captopril, enalapril, ramipril)angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)beta-adrenergic blockers (e.g., metoprolol, atenolol)baclofenbarbiturates (e.g., butalbital, phenobarbital)benzodiazepines (e.g., alprazolam, diazepam, lorazepam)calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)celecoxibcilostazol“azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)clopidogrelcorticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)cyclosporinediuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)5-ASA medications (e.g, sulfasalazine)glucosaminehaloperidolheparinmethotrexatemultivitaminsother non-steroidal anti-inflammatory medications (NSAIDs;e.g., diclofenac, ibuprofen, ketorolac, naproxen)Omega-3 fatty acidsphenytoinphenobarbitalpentoxifyllinequinolone antibiotics (e.g., ciprofloxacin, ofloxacin)selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., duloxetine, venlafaxine)tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)warferinOther NSAIDs: Concomitant therapy with aspirin or other NSAIDs may increase the frequency of adverse reactions, including the risk of GI bleeding.Pregnancy& Lactation of AceclofenacFDA Pregnancy Category C PregnancyThere is no information on the secretion of aceclofenac in breast milk. The use of aceclofenac should, therefore, be avoided during lactation unless the potential benefits to the mother outweigh the possible risks to the children. During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the fetus tocardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension);renal dysfunction, which may progress to renal failure with oligo-hydramnios;the mother and the neonate, at the end of pregnancy, topossible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses.inhibition of uterine contractions resulting in delayed or prolonged labor.Consequently, aceclofenac is contraindicated during the third trimester of pregnancyLactationThere is no information on the secretion of aceclofenac to breast milk; there was, however, no notable transfer of radiolabelled aceclofenac to the milk of lactating rats. The use of aceclofenac should, therefore, be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus. Show MoreReferencesDrugBankhttp://www.drugbank.ca/drugs/DB06736 http://www.drugbank.ca/drugs/DB06736#targets http://www.drugbank.ca/drugs/DB06736#enzymesChemIDplushttps://chem.nlm.nih.gov/chemidplus/sid/0089796996 https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jspEPA DSStoxhttps://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID7045522ClinicalTrials.govhttps://clinicaltrials.gov/FDA/SPL Indexing Datahttps://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/European Chemicals Agency (ECHA)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/174574MassBank of North America (MoNA)http://mona.fiehnlab.ucdavis.edu/spectra/browse?inchikey=MNIPYSSQXLZQLJ-UHFFFAOYSA-NSpectraBasehttps://spectrabase.com/compound/CGxLUfFIi3b#C9PfHXXAtaV https://spectrabase.com/compound/CGxLUfFIi3b#L2wjxBQy29M https://spectrabase.com/compound/CGxLUfFIi3b#3oUKgJVvGXASpringer Nature. Read more …The Cambridge Structural Databasehttp://www.ccdc.cam.ac.uk/pages/Home.aspxWHO ATChttps://www.whocc.no/atc/https://www.whocc.no/atc_ddd_index/Wikipediahttps://en.wikipedia.org/wiki/Aceclofenachttps://pubchem.ncbi.nlm.nih.govMeSHhttps://www.ncbi.nlm.nih.gov/mesh/67056498http://www.nlm.nih.gov/mesh/meshhome.html https://www.ncbi.nlm.nih.gov/mesh/68000894ChEBIhttp://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontologyhttps://www.pediatriconcall.com/drugs/aceclofenac/957https://www.drugs.com/international/aceclofenac.htmlKEGGhttp://www.genome.jp/kegg-bin/get_htext?br08303.keghttp://www.genome.jp/kegg-bin/get_htext?br08310.kegWIPOhttp://www.wipo.int/classifications/ipc/ChEMBLhttps://www.ebi.ac.uk/chembl/target/browserhttps://www.ncbi.nlm.nih.gov/projects/linkoutSaveSavedRemoved 0 PreviousAceclofenac Indications, Contraindications, Warning NextDiclofenac Indications, Contraindications, Warning Related ArticlesAdded to wishlistRemoved from wishlist 0 Vasodilator DrugsAdded to wishlistRemoved from wishlist 0 Methamphetamine Hydrochloride – Uses, Dosage, Side Effects, InteractionAdded to wishlistRemoved from wishlist 0 Methamphetamine – Uses, Dosage, Side Effects, InteractionsAdded to wishlistRemoved from wishlist 0 Vitamin D3 – Uses, Dosage, Side Effects, Interactions
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