A myeloma protein (often written as M-protein, monoclonal protein, paraprotein, or M-spike) is a single, abnormal antibody made in large amounts by a clone of ...

Endocrinopathy means any health problem that starts in the body’s hormone system. Your hormone system is called the endocrine system. It includes small but ...

Pancreatomegaly is a descriptive word, not a final diagnosis. It means the pancreas is bigger than usual. Doctors usually notice it on imaging tests such as ...

An enlarged ovary means one or both ovaries are bigger than usual. It is not a single disease—it is a sign that can happen for many reasons. The most common ...

Uteromegaly means the uterus is larger than normal. The uterus is a hollow, muscular organ in the pelvis that normally sits behind the bladder and in front of ...

Uterine megaly (also called uteromegaly or an enlarged uterus) means the uterus is bigger than expected for a person’s age, body size, and life stage. The ...

Prostatomegaly means the prostate gland is bigger than usual. Doctors also call it an “enlarged prostate.” The word comes from “prostate” (the male gland below ...

Thyromegaly means the thyroid gland is bigger than normal. The thyroid is a small, butterfly-shaped gland that sits in the front of your lower neck. It makes ...

Nephromegaly means the kidneys are bigger than normal for a person’s age and body size. Doctors usually judge kidney size with imaging, especially ultrasound. ...

Cardiomegaly means “an enlarged heart.” It is a finding, not a final diagnosis. In simple words, the heart looks bigger than normal, or one or more chambers of ...

Splenomegaly means the spleen is bigger than normal. The spleen sits high on the left side of your belly, just under the ribs. In healthy adults it is soft, ...

Hepatomegaly means the liver is larger than normal. The liver usually sits under the right rib cage and has a fairly consistent size and shape in healthy ...

Organomegaly means an internal organ is bigger than normal. The word comes from “organo” (organ) and “megaly” (big). Any organ can become large. The most ...

“Phakomatoses” (also called neurocutaneous syndromes) are conditions that affect the skin, the brain and nerves, and often other organs. The word comes from an ...

Moyamoya disease is a rare brain blood vessel problem where the main arteries that carry blood into the deep parts of the brain slowly become tight and narrow. ...

This phrase means all the eye problems and eye changes that can happen because of isotretinoin. Isotretinoin is a vitamin A–like drug (a retinoid) that shrinks ...

Hidradenitis suppurativa (HS) is a long-lasting skin disease. It causes painful lumps, boils, and “tunnels” under the skin. These bumps happen where skin rubs ...

Hemophagocytic Lymphohistiocytosis (HLH) is a dangerous “immune storm.” The body’s defender cells (T cells, NK cells, and macrophages) get stuck in the ON ...

Iron-Overloaded Syndrome means too much iron builds up in the body over time. Iron is essential for life. We need iron to make hemoglobin, which carries oxygen ...

Hemochromatosis is a condition where the body stores too much iron over many years. Iron is a normal mineral that helps make blood and carry oxygen. In ...