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body.rx-article-layout-full_width .rx-content-layout{display:block!important}body.rx-article-layout-full_width .rx-sidebar{display:none!important}body.rx-article-layout-full_width .rx-single-area{max-width:920px!important;margin-inline:auto!important;width:100%!important}
@media(min-width:1260px){body.rx-article-layout-right_sidebar .rx-content-layout{grid-template-columns:minmax(0,860px) 320px!important}body.rx-article-layout-right_sidebar .rx-content-layout:before{display:none!important}body.rx-article-layout-left_sidebar .rx-content-layout{grid-template-columns:320px minmax(0,860px)!important}body.rx-article-layout-left_sidebar .rx-single-area{grid-column:2!important}body.rx-article-layout-left_sidebar .rx-sidebar{grid-column:1!important;grid-row:1!important}}
/* RX v10.23.75.11.32 article experience cleanup boundary. */
body.rx-article-composition-enabled .rx-article-reach-strip{display:none!important}
.rx-article-reader-count{display:inline-flex;align-items:center;gap:6px}.rx-article-reader-count:before{content:"◉";color:#2563eb;font-size:.72em}
.rx-zone-before_content>.rx-module-patient_action_toolbar:first-child{margin-top:0}

/* RX v10.23.75.11.34 consolidated adaptive left-rail skin; one fewer stylesheet request. */
.rx-article-left-rail{display:none;min-width:0}
.rx-article-left-rail__sticky{border:1px solid #dbe5ef;border-radius:18px;background:linear-gradient(180deg,#ffffff 0%,#f8fbff 100%);box-shadow:0 12px 34px rgba(15,23,42,.07);padding:17px 14px 14px;overflow:auto;scrollbar-width:thin}
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.rx-article-left-rail h2{margin:0 0 12px;color:#132238;font-size:18px;line-height:1.25;letter-spacing:-.02em}
.rx-left-rail-progress{height:5px;margin:0 0 14px;border-radius:999px;background:#e6eef7;overflow:hidden}
.rx-left-rail-progress>span{display:block;width:0;height:100%;border-radius:inherit;background:linear-gradient(90deg,#0b8f80,#2563eb);transition:width .12s linear}
.rx-adaptive-toc-list{list-style:none;margin:0;padding:0}
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.rx-inline-toc-count{margin-left:auto;color:#64748b;font-size:12px;font-weight:700}
.rx-article-inline-toc nav{padding:0 16px 15px;border-top:1px solid #e1e9f1}
.rx-adaptive-toc-list--inline{padding-top:9px}
.rx-adaptive-toc-list--inline .rx-adaptive-toc-item a{padding:8px 9px}
.rx-adaptive-toc-list--inline .rx-adaptive-toc-item--level-3 a{padding-left:25px;font-size:13px}
body.rx-dark-mode .rx-article-left-rail__sticky,body.rx-dark-mode .rx-article-inline-toc{background:#111827;border-color:#2b3a4f}
body.rx-dark-mode .rx-article-left-rail h2,body.rx-dark-mode .rx-article-inline-toc>summary{color:#f8fafc}
body.rx-dark-mode .rx-adaptive-toc-item a{color:#aebed0}
body.rx-dark-mode .rx-adaptive-toc-item a.is-active{background:#172554;color:#bfdbfe}
@media(min-width:1260px){
 body.rx-article-composition-enabled.rx-article-layout-three_part.rx-article-has-left-rail .rx-article-left-rail{display:block}
 body.rx-article-composition-enabled.rx-article-layout-three_part.rx-article-has-left-rail .rx-article-left-rail__sticky{position:sticky;top:calc(var(--wp-admin--admin-bar--height,0px) + 92px);max-height:calc(100vh - var(--wp-admin--admin-bar--height,0px) - 116px)}
 body.rx-article-composition-enabled.rx-article-layout-three_part.rx-article-has-left-rail .rx-module-table_of_contents{display:none!important}
}
@media(max-width:1259px){.rx-article-left-rail{display:none!important}}
@media(max-width:640px){
 .rx-article-inline-toc{margin:14px 0 18px;border-radius:14px}
 .rx-article-inline-toc>summary{padding:13px 14px}
 .rx-inline-toc-count{display:none}
}
@media print{.rx-article-left-rail,.rx-article-inline-toc{display:none!important}}
/* RX Theme v10.23.75.11.34 Modern Medical Article Experience + Performance Guardian */
body.rx-modern-medical-article .rx-article-title,
body.rx-modern-medical-article .rx-medical-entry-content :where(h2,h3,h4){text-wrap:balance}
body.rx-modern-medical-article .rx-medical-entry-content{text-wrap:pretty;overflow-wrap:anywhere}
body.rx-modern-medical-article .rx-medical-entry-content :where(h2,h3,h4){scroll-margin-top:calc(var(--wp-admin--admin-bar--height,0px) + 112px)}
body.rx-modern-medical-article .rx-medical-entry-content :where(a:not(.wp-element-button)){text-decoration-thickness:.08em;text-underline-offset:.18em;text-decoration-skip-ink:auto}
body.rx-modern-medical-article :where(a,button,summary,input,select,textarea):focus-visible{outline:3px solid rgba(21,94,239,.28);outline-offset:3px}
body.rx-modern-medical-article .rx-article-featured-image{isolation:isolate}
body.rx-modern-medical-article .rx-article-featured-image img{display:block;width:100%;height:auto}
body.rx-modern-medical-article .rx-medical-entry-content :where(figure.wp-block-image,figure.wp-caption){margin-block:clamp(24px,4vw,38px)}
body.rx-modern-medical-article .rx-medical-entry-content :where(figcaption,.wp-caption-text){margin-top:10px;color:#64748b;font-size:.84em;line-height:1.55;text-align:center}
body.rx-modern-medical-article .rx-medical-entry-content blockquote{margin-block:clamp(24px,4vw,36px);padding:18px 20px;border:1px solid #dbe7f2;border-left:5px solid #0b8f80;border-radius:0 16px 16px 0;background:linear-gradient(135deg,#f7fbff,#f1fbf8);color:#20344f}
body.rx-modern-medical-article .rx-medical-entry-content blockquote>:first-child{margin-top:0}
body.rx-modern-medical-article .rx-medical-entry-content blockquote>:last-child{margin-bottom:0}
body.rx-modern-medical-article .rx-medical-entry-content :where(ul,ol)>li::marker{color:#0b7a70;font-weight:800}
body.rx-modern-medical-article .rx-medical-entry-content hr{height:1px;margin:42px 0;border:0;background:linear-gradient(90deg,transparent,#cbd8e6 18%,#cbd8e6 82%,transparent)}
body.rx-modern-medical-article .rx-medical-entry-content iframe{max-width:100%;border-radius:16px;background:#eef3f8}
body.rx-modern-medical-article .rx-article-composition-module{scroll-margin-top:calc(var(--wp-admin--admin-bar--height,0px) + 104px)}
@supports (content-visibility:auto){
 body.rx-article-performance-guarded .rx-zone-after_content>.rx-article-composition-module,
 body.rx-article-performance-guarded .rx-zone-after_article>.rx-article-composition-module{content-visibility:auto;contain-intrinsic-size:auto 420px}
}
body.rx-dark-mode.rx-modern-medical-article .rx-medical-entry-content :where(figcaption,.wp-caption-text){color:#9fb0c5}
body.rx-dark-mode.rx-modern-medical-article .rx-medical-entry-content blockquote{border-color:#304158;border-left-color:#2dd4bf;background:linear-gradient(135deg,#111827,#10211f);color:#dbe8f5}
@media(max-width:640px){
 body.rx-modern-medical-article .rx-medical-entry-content blockquote{padding:15px 16px;border-radius:0 13px 13px 0}
 body.rx-modern-medical-article .rx-medical-entry-content :where(h2,h3,h4){scroll-margin-top:92px}
}
@media print{
 body.rx-article-performance-guarded .rx-zone-after_content>.rx-article-composition-module,
 body.rx-article-performance-guarded .rx-zone-after_article>.rx-article-composition-module{content-visibility:visible!important;contain-intrinsic-size:auto!important}
}
@media(prefers-reduced-motion:reduce){
 body.rx-modern-medical-article *,body.rx-modern-medical-article *::before,body.rx-modern-medical-article *::after{scroll-behavior:auto!important;transition-duration:.01ms!important;animation-duration:.01ms!important;animation-iteration-count:1!important}
}

/* RX Theme v10.23.75.11.35 Calm Focus Reading + Smart Resume Continuity Guardian */
.rx-reading-continuity-controls{margin-top:13px;padding-top:12px;border-top:1px solid #e1e9f1}
.rx-reading-continuity-row,.rx-reading-continuity-controls--inline{display:flex;align-items:center;gap:9px;flex-wrap:wrap}
.rx-focus-reading-button{appearance:none;min-height:34px;padding:7px 10px;border:1px solid #c8d7e6;border-radius:10px;background:#fff;color:#155eef;font:inherit;font-size:12px;font-weight:850;line-height:1.2;cursor:pointer;box-shadow:0 1px 2px rgba(15,23,42,.04)}
.rx-focus-reading-button:hover{border-color:#8db4ec;background:#eef5ff;color:#0d4fd7}
.rx-focus-reading-button[aria-pressed="true"]{border-color:#0b8f80;background:#eafaf7;color:#067267}
.rx-reading-percent{margin-left:auto;color:#64748b;font-size:11px;font-weight:800;white-space:nowrap}
.rx-reading-resume{display:grid;gap:3px;margin-top:10px;padding:9px 10px;border-radius:11px;background:#edf7ff;color:#52647a;font-size:11px;line-height:1.35}
.rx-reading-resume>span{font-weight:800;text-transform:uppercase;letter-spacing:.05em}
.rx-reading-resume a{color:#0d4fd7;font-weight:850;text-decoration:none;overflow-wrap:anywhere}
.rx-reading-resume a:hover{text-decoration:underline}
.rx-reading-continuity-controls--inline{margin:10px 0 2px;padding:10px 0 4px;border-top:0;border-bottom:1px solid #e1e9f1}
.rx-reading-continuity-controls--inline .rx-reading-resume{flex:1 0 100%;margin-top:2px}
.rx-section-link-button{display:inline-grid;place-items:center;width:28px;height:28px;margin-left:8px;padding:0;border:0;border-radius:8px;background:transparent;color:#8aa0b7;font:inherit;font-size:.7em;font-weight:900;line-height:1;vertical-align:.12em;cursor:pointer;opacity:0;transform:translateY(-1px);transition:opacity .16s ease,background .16s ease,color .16s ease,transform .16s ease}
.rx-medical-entry-content :where(h2,h3):hover>.rx-section-link-button,.rx-section-link-button:focus-visible,.rx-section-link-button.is-copied{opacity:1}
.rx-section-link-button:hover{background:#eaf2ff;color:#155eef;transform:translateY(-1px) scale(1.04)}
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.rx-screen-reader-status{position:fixed!important;width:1px!important;height:1px!important;padding:0!important;margin:-1px!important;overflow:hidden!important;clip:rect(0,0,0,0)!important;white-space:nowrap!important;border:0!important}
.rx-section-target-flash{animation:rx-section-target-flash 1.8s ease-out}
@keyframes rx-section-target-flash{0%{background:rgba(37,99,235,.16);box-shadow:0 0 0 8px rgba(37,99,235,.08)}100%{background:transparent;box-shadow:0 0 0 0 transparent}}
body.rx-focus-reading-active .rx-site-main.rx-container>.rx-content-layout{display:block!important;width:min(100%,980px)!important;max-width:980px!important;margin-inline:auto!important}
body.rx-focus-reading-active .rx-site-main.rx-container>.rx-content-layout>.rx-article-left-rail,body.rx-focus-reading-active .rx-site-main.rx-container>.rx-content-layout>.rx-sidebar{display:none!important}
body.rx-focus-reading-active .rx-site-main.rx-container>.rx-content-layout>.rx-single-area{display:block!important;width:100%!important;max-width:920px!important;margin-inline:auto!important;grid-column:auto!important}
body.rx-focus-reading-active .rx-module-table_of_contents{display:block!important}
body.rx-focus-reading-active .rx-article-inline-toc{display:block!important}
body.rx-focus-reading-active .rx-article-inline-toc .rx-adaptive-toc-list{columns:2;column-gap:22px}
body.rx-dark-mode .rx-reading-continuity-controls{border-color:#2b3a4f}
body.rx-dark-mode .rx-focus-reading-button{border-color:#3b4d64;background:#111827;color:#bfdbfe}
body.rx-dark-mode .rx-focus-reading-button:hover{background:#172554;color:#dbeafe}
body.rx-dark-mode .rx-focus-reading-button[aria-pressed="true"]{border-color:#2dd4bf;background:#102a27;color:#99f6e4}
body.rx-dark-mode .rx-reading-percent{color:#9fb0c5}
body.rx-dark-mode .rx-reading-resume{background:#122238;color:#aebed0}
body.rx-dark-mode .rx-reading-resume a{color:#bfdbfe}
body.rx-dark-mode .rx-section-link-button{color:#7890aa}
body.rx-dark-mode .rx-section-link-button:hover{background:#172554;color:#bfdbfe}
@media(hover:none){.rx-section-link-button{opacity:.65}}
@media(max-width:782px){body.rx-focus-reading-active .rx-site-main.rx-container>.rx-content-layout{width:100%!important}.rx-reading-continuity-controls--inline{align-items:flex-start}.rx-reading-percent{margin-left:0}body.rx-focus-reading-active .rx-article-inline-toc .rx-adaptive-toc-list{columns:1}}
@media(prefers-reduced-motion:reduce){.rx-section-target-flash{animation:none;outline:3px solid rgba(37,99,235,.22);outline-offset:4px}}
@media print{.rx-reading-continuity-controls,.rx-section-link-button{display:none!important}body.rx-focus-reading-active .rx-site-main.rx-container>.rx-content-layout>.rx-sidebar{display:none!important}}