Cefuzonam is an injectable, semi-synthetic second-generation cephalosporin with broad-spectrum antibiotic activity.it is a second-generation cephalosporin type of antibiotic medication used to treat bacterial infections. Its antibacterial activity is due to the presence of a beta-lactam core structure, which binds with penicillin-binding proteins within bacterial cells, thereby inhibiting cell wall synthesis.
Mechanism of Action of Cefuzonam
Cephalosporins exert bactericidal activity by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.
Indications of Cefuzonam
- Acute Bacterial Exacerbation of Chronic Bronchitis
- Bladder Infection
- Kidney Infections
- Bronchitis
- Otitis Media
- Pneumonia
- Sinusitis
- Skin or soft tissue infection
- Tonsillitis/Pharyngitis
- Upper respiratory tract infection
- Bacterial infections
- Community acquired pneumonia
- Streptococcal pharyngitis
- Streptococcal tonsillitis
- Urinary tract Infections
- Uncomplicated skin and subcutaneous tissue bacterial infections
Contra Indications of Cefuzonam
- Clostridium difficile infection
- Decrease in the Blood-Clotting Protein Prothrombin
- severe renal impairment
- Liver problems
- Interstitial Nephritis
- Subacute cutaneous lupus erythematosus
- Systemic Lupus Erythematosus
- Allergies cephalosporins & betalactams
Side Effects of Cefuzonam
The most common
- Nausea and vomiting
- Abdominal or stomach pain, discomfort, or tenderness
- Severe stomach ache
- Severe diarrhea
- Vaginal thrush
- Skin rash
- Headache
- chest pain
- constipation
- cough
- diarrhea or loose stools
- difficulty with breathing
- dizziness
- heartburn
- muscle pain
More common
- Abdominal or stomach pain, discomfort, or tenderness
- chills or fever
- difficulty with moving
- headache, severe and throbbing
- joint or back pain
- muscle aching or cramping
- muscle pains or stiffness
- chest pressure or squeezing pain in chest
- discomfort in arms, shoulders, neck or upper back
- excessive sweating
- feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
- sudden tingling or coldness in an arm or leg
- sudden slow or difficult speech
- sudden drowsiness or need to sleep
- fast breathing
- sharp pain when taking a deep breath
- fast or slow heartbeat
- coughing up blood
- rust colored urine
- decreased amount of urine
Rare
- Anxiety
- change in vision
- seizures
- abnormal or fast heart rate
- tremors
- weight loss
- chest pain or tightness
- confusion
- cough
- Agitation
- arm, back, or jaw pain
- blurred vision
- chest pain or discomfort
- convulsions
- extra heartbeats
- fainting
- hallucinations
- headache
- irritability
- lightheadedness
- mood or mental changes
- muscle pain or cramps
- muscle spasm or jerking of all extremities
Data or information not availabe. For furthers inquery …..
https://pubchem.ncbi.nlm.nih.gov/compound/Cefuzonam
