Cefmenoxime; Indications/Uses, Dosage, Side effects, Interactions

The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmenoxime is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.

Indications of Cefmenoxime

For the treatment of infections due to susceptible strains of microorganisms.

• Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria.
• Intra-Abdominal
• For the treatment of serious infections caused by susceptible strains microorganisms.
• Lower respiratory tract infections, including pneumonia and lung abscess,s
•  Urinary tract infections caused by Escherichia coli, Klebsiella species,
• Intra-abdominal infections, including peritonitis and intra-abdominal abscess,
• Gynecological infections, including endometritis, pelvic cellulitis, and pelvic inflammatory disease caused
• Bacterial Infections
• Bloodstream Infections
• Bone and Joint Infections
• Aspiration Pneumonia Cesarean Section

Contra-Indications of Cefmenoxime

• Hemolytic anemia
• Liver problems
• Interstitial nephritis
• Subacute cutaneous lupus erythematosus
• Systemic lupus erythematosus
• Allergies cephalosporins & beta-lactams

Side Effects of Cefmenoxime

The most common

• mild nausea
• loss of appetite
• vaginal discharge and itching
• swelling of feet or legs
• chest pain
• constipation
• local tenderness or pain at the site of injection
• skin color change, mild diarrhea
• a cough
• diarrhea or loose stools
• difficulty with breathing
• dizziness
• heartburn

More common

• Abdominal or stomach pain, discomfort, or tenderness
• chills or fever
• difficulty with moving
• a headache, severe and throbbing
• joint or back pain
• muscle aching or cramping
• muscle pains or stiffness
• chest pressure or squeezing pain in chest
• excessive sweating
• feeling of heaviness, pain, warmth and/or swelling in a leg or in the pelvis
• sudden tingling or coldness in an arm or leg
• sudden slow or difficult speech
• sudden drowsiness or need to sleep
• fast breathing
• sharp pain when taking a deep breath
• fast or slow heartbeat
• coughing up blood
• rust colored urine
• decreased amount of urine

Rare

• Anxiety
• change in vision
• seizures
• abnormal or fast heart rate
• tremors
• weight loss
• chest pain or tightness
• confusion
• cough
• Agitation
• arm, back, or jaw pain
• blurred vision
• chest pain or discomfort
• convulsions
• extra heartbeats
• fainting
• hallucinations
• a headache
• irritability
• lightheadedness
• mood or mental changes
• muscle pain or cramps

Drug Interactions

Cefmenoxime may interact with the following drugs, supplements, & may change the efficacy of drugs

• aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
• probenecid
• typhoid vaccine
• cholera vaccine,
• amoxicillin
• BCG vaccine
• Aspirin Low Strength (aspirin) 
• Diphenhydramine
• Rosuvastatin
• Duloxetine
• Albuterol
• Topiramate
• Carbamazepine
• Vitamin D3 (cholecalciferol)
• Alprazolam
• Cetirizine
• Phenprocoumon
• Picosulfuric acid
• Warfarin

Pregnancy Catagory

FDA Pregnancy Category  B

Pregnancy

It is not known if cefmenoxime is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Lactation

This medication may pass into breast milk. If you are a breast-feeding mother and are taking cefmenoxime it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. It is not known if cefmenoxime is safe for children under 6 months of age.

References

1. ChemIDplus

   https://chem.nlm.nih.gov/chemidplus/sid/0065085010

   https://chem.nlm.nih.gov/chemidplus/sid/0075738588

   https://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp

   https://www.webmd.com/drugs/cefmenoxime -oral/details/list-contraindications

2. DrugBank

   http://www.drugbank.ca/drugs/DB00267
   http://www.drugbank.ca/drugs/DB00267#targets

3. EPA DSStox

   https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID2022755

4. European Chemicals Agency – ECHA

   https://www.echa.europa.eu

   https://www.echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-database/-/discli/details/19833

5. Human Metabolome Database (HMDB)

   http://www.hmdb.ca/metabolites/HMDB0014412

6. NCC

   https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C65295

7. FDA/SPL Indexing Data

   https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/

8. FDA Orange Book

   https://www.fda.gov/Drugs/InformationOnDrugs/ucm129662.htm

9. WHO ATC

   https://www.whocc.no/atc/

   https://www.whocc.no/atc_ddd_index/

10. Wikipedia

    https://www.wikidata.org/wiki/Q27881861

    https://en.wikipedia.org/wiki/Cefmenoxime

    https://pubchem.ncbi.nlm.nih.gov

11. MeSH

    https://www.ncbi.nlm.nih.gov/mesh/68015281

    http://www.nlm.nih.gov/mesh/meshhome.html

    https://www.ncbi.nlm.nih.gov/mesh/68000900

    https://www.drugs.com/international/cefmenoxime-hydrochloride.html

12. ChEBI

    http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology

13. KEGG

    http://www.genome.jp/kegg-bin/get_htext?br08303.keg