Glioblastoma Multiforme (GBM)

Glioblastoma multiforme (GBM) is a type of brain cancer that starts in the brain or spinal cord. It’s a very aggressive and fast-growing tumor that can cause various symptoms depending on its size and location.


There’s generally one type of GBM, but it can sometimes be categorized based on specific genetic mutations or characteristics.


  1. Genetic mutations: Changes in certain genes can lead to the development of GBM.
  2. Radiation exposure: Previous exposure to radiation therapy, especially for other brain conditions, can increase the risk.
  3. Age: GBM is more common in older adults.
  4. Family history: In rare cases, there might be a genetic predisposition to developing brain tumors.
  5. Environmental factors: Certain environmental toxins or chemicals might contribute to the risk.
  6. Immune system issues: Weak immune systems might be less effective at fighting off abnormal cell growth.
  7. Prior head injury: A history of head trauma could potentially increase the risk.
  8. Viral infections: Some viruses may be associated with an increased risk of GBM.
  9. Hormonal factors: Imbalances in certain hormones could potentially play a role.
  10. Ethnicity: Some studies suggest that certain ethnic groups might be more susceptible.


  1. Headaches: Persistent and worsening headaches are a common symptom.
  2. Seizures: Unexplained seizures or changes in seizure patterns can occur.
  3. Nausea and vomiting: Especially if they’re unrelated to other conditions or medications.
  4. Cognitive changes: Memory problems, confusion, or changes in thinking abilities.
  5. Weakness or numbness: Especially on one side of the body.
  6. Vision changes: Blurred vision, double vision, or loss of vision in one eye.
  7. Speech difficulties: Slurred speech or difficulty finding the right words.
  8. Changes in personality: Mood swings, irritability, or depression.
  9. Balance and coordination issues: Difficulty walking or maintaining balance.
  10. Fatigue: Persistent tiredness or lack of energy.

Diagnostic Tests:

  1. Medical history: A detailed discussion about symptoms, medical history, and family history.
  2. Physical examination: A neurological examination to assess reflexes, coordination, and sensory functions.
  3. Imaging tests: MRI or CT scans to visualize the brain and detect any abnormalities.
  4. Biopsy: Removal of a small tissue sample for microscopic examination to confirm the diagnosis.
  5. Blood tests: Checking for certain markers or substances that might indicate brain tumor activity.


Non-pharmacological treatments for GBM include:

  1. Surgery: Removing as much of the tumor as possible to relieve pressure on the brain.
  2. Radiation therapy: Using high-energy beams to target and kill cancer cells.
  3. Chemotherapy: Administering powerful drugs to destroy cancer cells.
  4. Tumor-treating fields: Using a device to deliver electrical fields to disrupt cancer cell division.
  5. Laser interstitial thermal therapy: Using focused laser energy to heat and destroy tumor cells.
  6. Immunotherapy: Stimulating the immune system to recognize and attack cancer cells.
  7. Targeted therapy: Using drugs that specifically target certain genetic mutations or pathways in cancer cells.
  8. Supportive care: Managing symptoms and providing supportive therapies to improve quality of life.
  9. Rehabilitation: Physical therapy, occupational therapy, or speech therapy to regain lost functions.
  10. Palliative care: Providing comfort and symptom management for patients with advanced disease.


  1. Temozolomide: An oral chemotherapy drug commonly used to treat GBM.
  2. Bevacizumab: A targeted therapy drug that inhibits blood vessel formation in tumors.
  3. Carmustine (BCNU): A chemotherapy drug sometimes used in combination with radiation therapy.
  4. Lomustine (CCNU): Another chemotherapy drug used in the treatment of GBM.
  5. Etoposide: A chemotherapy drug that interferes with cancer cell division.
  6. Irinotecan: A chemotherapy drug that inhibits DNA replication in cancer cells.
  7. Methotrexate: A chemotherapy drug that interferes with folate metabolism in cancer cells.
  8. Carboplatin: A chemotherapy drug often used in combination with other agents.
  9. Vincristine: A chemotherapy drug that disrupts microtubule formation in cancer cells.
  10. Cisplatin: A chemotherapy drug that forms cross-links in DNA, inhibiting cell division.


  1. Craniotomy: Surgical removal of part of the skull to access and remove the tumor.
  2. Biopsy: Surgical removal of a small tissue sample for diagnostic purposes.
  3. Debulking surgery: Removing as much of the tumor as possible to reduce its size and symptoms.
  4. Awake craniotomy: Performing surgery while the patient is awake to minimize damage to critical brain areas.
  5. Stereotactic biopsy: Using imaging guidance to precisely target and remove tissue samples.
  6. Endoscopic surgery: Minimally invasive surgery using a thin tube with a camera to visualize and remove the tumor.
  7. Laser ablation: Using focused laser energy to heat and destroy tumor cells.
  8. Shunt placement: Inserting a tube to drain excess cerebrospinal fluid and relieve pressure on the brain.
  9. Ventriculostomy: Creating a small hole in the skull to drain fluid buildup in the brain.
  10. Neurostimulation: Using electrical stimulation to modulate brain activity and control symptoms.


While there’s no guaranteed way to prevent GBM, some strategies may help reduce the risk:

  1. Avoiding unnecessary radiation exposure.
  2. Protecting the head from injury.
  3. Maintaining a healthy lifestyle with a balanced diet and regular exercise.
  4. Avoiding known carcinogens or toxins.
  5. Managing underlying health conditions effectively.
  6. Seeking prompt medical attention for any concerning symptoms.
  7. Discussing potential risks with healthcare providers before undergoing medical procedures.
  8. Considering genetic counseling for individuals with a family history of brain tumors.
  9. Participating in clinical trials to advance research and treatment options.
  10. Staying informed about new developments in brain cancer prevention and treatment.

When to See a Doctor:

It’s essential to consult a healthcare provider if you experience any persistent or concerning symptoms, especially:

  1. New or worsening headaches, especially if they’re severe or accompanied by other symptoms.
  2. Seizures, particularly if they occur suddenly and without a known cause.
  3. Cognitive changes, such as memory problems or difficulty concentrating.
  4. Motor difficulties, such as weakness, numbness, or problems with coordination.
  5. Vision changes, including blurred vision, double vision, or vision loss.
  6. Speech difficulties, such as slurred speech or difficulty finding the right words.
  7. Persistent nausea, vomiting, or unexplained weight loss.
  8. Changes in mood or behavior, such as depression, irritability, or personality changes.
  9. Balance problems or difficulty walking.
  10. Fatigue or weakness that doesn’t improve with rest.

Early detection and prompt treatment can improve outcomes for individuals with GBM, so it’s essential not to ignore any potential warning signs. Your healthcare provider can perform a thorough evaluation and recommend appropriate diagnostic tests and treatment options based on your individual circumstances.


Disclaimer: Each person’s journey is unique, treatment plan, life style, food habit, hormonal condition, immune system, chronic disease condition, geological location, weather and previous medical  history is also unique. So always seek the best advice from a qualified medical professional or health care provider before trying any treatments to ensure to find out the best plan for you. This guide is for general information and educational purposes only. If you or someone are suffering from this disease condition bookmark this website or share with someone who might find it useful! Boost your knowledge and stay ahead in your health journey. Thank you for giving your valuable time to read the article.