Sotorasib - Uses, Dosage, Side Effects, Interaction - Rxharun

Sotorasib – Uses, Dosage, Side Effects, Interaction

Mechanism of Action

Normally GTP binds to KRAS, activating the protein and promoting effectors to the MAP kinase pathway. GTP is hydrolyzed to GDP, and KRAS is inactivated. KRAS G12C mutations impair the hydrolysis of GTP, leaving it in its active form. Sotorasib binds to the cysteine residue in KRAS G12C mutations, holding the protein in its inactive form. The cysteine residue that sotorasib targets are not present in the wild-type KRAS, which prevents off-target effects. This mutation is present in 13% of non-small cell lung cancer, 3% of colorectal and appendix cancer, and 1-3% of solid tumors.

Sotorasib is indicated in the treatment of adults with KRAS G12C mutant nonsmall cell lung cancer. It has a moderate duration of action as it is given daily. Patients should be counseled regarding the risks of hepatotoxicity, interstitial lung disease, and pneumonitis; and to avoid breastfeeding during treatment and up to 1 week after the last dose.

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Pregnancy and Lactation

US FDA pregnancy category: Not assigned.

breastfeed during treatment with LUMAKRAS and for 1 week after the final dose.

How should this medicine be used?

Sotorasib comes as a tablet to take by mouth. It is usually taken once daily with or without food. Take sotorasib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sotorasib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

If you cannot swallow the tablets whole, place the tablets in a glass of 4 ounces (120 mL) of non-carbonated, room-temperature water. Do not use any other liquids other than water. Stir until the tablets are in small pieces. Do not crush the tablets; they will not completely dissolve. Drink the mixture right away or within 2 hours of preparing. Do not chew pieces of the tablet. Rinse the glass with an additional 4 ounces (120 mL) of water and drink to make sure that you have taken the full dose. If you do not drink the mixture right away, stir the mixture again before drinking.

If you vomit after taking sotorasib, do not take another dose. Continue your regular dosing schedule the next day.

Your doctor may temporarily or permanently stop your treatment or adjust your dose of sotorasib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take sotorasib even if you feel well. Do not stop taking sotorasib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

What special precautions should I follow?

Before taking sotorasib,

  • tell your doctor and pharmacist if you are allergic to sotorasib, any other medications, or any of the ingredients in sotorasib tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • The following nonprescription or herbal products may interact with sotorasib: cimetidine (Tagamet HB), esomeprazole (Nexium), famotidine (Pepcid), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), and ranitidine. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking sotorasib. Do not start any of these medications while taking sotorasib without discussing with your healthcare provider
  • if you are taking sotorasib and an antacid, take sotorasib either 4 hours before or 10 hours after the antacid.
  • tell your doctor if you have or have ever had liver disease, or lung or breathing problems other than lung cancer.
  • tell your doctor if you are pregnant, or plan to become pregnant. If you become pregnant while taking sotorasib, call your doctor immediately.
  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while receiving sotorasib and for 1 week after your final dose.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it has been more than 6 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.


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