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Ixazomib is an active metabolite of MLN9708, a second-generation, boron-containing peptide proteasome inhibitor (PI) or proteasome inhibitor with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first-generation PIs, second-generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.
Ixazomib is a small-molecule proteasome inhibitor that is used in combination with other antineoplastic agents to treat refractory multiple myeloma. Ixazomib is associated with a low rate of serum enzyme elevations during treatment and with rare instances of clinically apparent, acute liver injury.
Ixazomib is a glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzene)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for the treatment of multiple myeloma. It has a role as an apoptosis inducer, an orphan drug, a proteasome inhibitor, a drug metabolite, and an antineoplastic agent. It is a member of benzamides, a dichlorobenzene, a glycine derivative and a member of boronic acids.
Ixazomib Citrate is the citrate salt form of ixazomib, an orally bioavailable second-generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first-generation PIs, second-generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.
Ixazomib citrate is a glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzene)glycine with the amino group of 2,2′-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid. A prodrug for ixazomib that is used in combination therapy for the treatment of multiple myeloma. It has a role as a prodrug, a proteasome inhibitor, an orphan drug, an antineoplastic agent, and an apoptosis inducer. It is a glycine derivative, a member of benzamides, a dichlorobenzene, an oxo dicarboxylic acid, and a 1,3,2-dioxaborolane. It is functionally related to an ixazomib.
Mechanism of Action
Ixazomib is an N-capped dipeptidyl leucine boronic acid that reversibly inhibits the CT-L proteolytic (β5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic β1 and β2 subunits and induce the accumulation of ubiquitinated proteins. In vitro studies have shown ixazomib to induce apoptosis in multiple myeloma cells sensitive or resistant to other conventional therapies. In mouse xenograft models, ixazomib induced tumor growth inhibition.
At therapeutic concentrations, ixazomib selectively and reversibly inhibits the protein proteasome subunit beta type-5 (PSMB5)[rx] with a dissociation half-life of 18 minutes. This mechanism is the same as that of bortezomib, which has a much longer dissociation half-life of 110 minutes; the related drug carfilzomib, by contrast, blocks PSMB5 irreversibly. Proteasome subunits beta type-1 and type-2 are only inhibited at high concentrations reached in cell culture models.[rx]
PSMB5 is part of the 20S proteasome complex and has an enzymatic activity similar to chymotrypsin. It induces apoptosis, a type of programmed cell death, in various cancer cell lines. A synergistic effect of ixazomib and lenalidomide has been found in a large number of myeloma cell lines. Ixazomib a second-generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy.
Indications
- Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. It is used in combination with dexamethasone and lenalidomide in patients who have had one prior treatment, allowing patients to be on a fully oral regimen, which has been proven to have a progression-free survival benefit.[rx][rx]
- Treatment of lymphoid malignancies (excluding multiple myeloma)
- Ixazomib is a small-molecule proteasome inhibitor that is used in combination with other antineoplastic agents to treat refractory multiple myeloma
- Treatment of systemic light chain amyloidosis.
- Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.
Use in Cancer
Ixazomib citrate is approved to be used with lenalidomide and dexamethasone to treat:
- Multiple myeloma in patients who have already received at least one other type of treatment.
Ixazomib citrate is also being studied in the treatment of other types of cancer.
Contraindications
- decreased blood platelets
- low levels of a type of white blood cell called neutrophils
- a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
- liver problems
- fluid retention in the legs, feet, arms or hands
- abnormal liver function tests
- pregnancy
- a patient who is producing milk and breastfeeding
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function
- Child-Pugh class B liver impairment
- Child-Pugh class C liver impairment
Dosage
Strengths: 2.3 mg; 3 mg; 4 mg
Multiple Myeloma
- 4 mg orally once a week on Days 1, 8, and 15 of a 28-day cycle
- This drug is only given in combination with lenalidomide and dexamethasone.
- For additional information regarding lenalidomide and dexamethasone, refer to their prescribing information.
- Antiviral prophylaxis should be considered to decrease the risk of herpes zoster reactivation.
- Prior to initiating a new cycle of therapy:
- The absolute neutrophil count should be at least 1,000/mm3, the Platelet count should be at least 75,000/mm3, and Nonhematologic toxicities should, at physician discretion, generally be recovered to patient baseline condition or Grade 1 or lower
- Treatment should be continued until the disease progresses or has unacceptable toxicity.
- In combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy
Dose Adjustments
DOSE REDUCTIONS DUE TO ADVERSE REACTIONS:
- Recommended starting dose: 4 mg
- First reduction recommendation: 3 mg
- Second reduction recommendation: 2.3 mg
- Discontinue therapy
DOSE MODIFICATION GUIDELINES FOR THIS DRUG IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE:
THROMBOCYTOPENIA:
Platelet count less than 30,000/mm3:
- Withhold this drug and lenalidomide until the platelet count is at least 30,000/mm3.
- Following recovery, resume lenalidomide at the next lower dose according to its prescribing information and resume this drug at its most recent dose.
- If the platelet count falls to less than 30,000/mm3 again, withhold this drug and lenalidomide until the platelet count is at least 30,000/mm3.
- Following recovery, resume this drug at the next lower dose and resume lenalidomide at its most recent dose.
NEUTROPENIA:
Absolute neutrophil count less than 500/mm3:
- Withhold this drug and lenalidomide until the absolute neutrophil count is at least 500/mm3. Consider adding granulocyte colony-stimulating factor (G-CSF) as per clinical guidelines.
- Following recovery, resume lenalidomide at the next lower dose according to its prescribing information and resume this drug at its most recent dose.
- If the absolute neutrophil count falls to less than 500/mm3 again, withhold this drug and lenalidomide until the absolute neutrophil count is at least 500/mm3.
- Following recovery, resume this drug at the next lower dose and resume lenalidomide at its most recent dose.
NONHEMATOLOGIC TOXICITIES RECOMMENDED DOSE MODIFICATIONS:
Grade 2 or 3 rash:
- Withhold lenalidomide until the rash recovers to Grade 1 or lower.
- Following recovery, resume lenalidomide at the next lower dose according to its prescribing information.
- If a Grade 2 or 3 rash occurs again, withhold this drug and lenalidomide until the rash recovers to Grade 1 or lower.
- Following recovery, resume this drug at the next lower dose and resume lenalidomide at its most recent dose.
Grade 4 rash:
- Discontinue therapy.
PERIPHERAL NEUROPATHY RECOMMENDED DOSE MODIFICATIONS:
Grade 1 peripheral neuropathy with pain or Grade 2 peripheral neuropathy:
- Withhold this drug until peripheral neuropathy recovers to Grade 1 or lower without pain or the patient’s baseline.
- Following recovery, resume this drug at its most recent dose.
Grade 2 peripheral neuropathy with pain or Grade 3 peripheral neuropathy:
- Withhold this drug. Toxicities should, at the physician’s discretion, generally recover to the patient’s baseline condition or Grade 1 or lower prior to resuming this drug.
- Following recovery, resume this drug at the next lower dose.
Grade 4 peripheral neuropathy:
- Discontinue therapy.
OTHER NONHEMATOLOGIC TOXICITIES RECOMMENDED DOSE MODIFICATIONS:
Other Grade 3 or 4 nonhematological toxicities:
- Withhold this drug. Toxicities should, at the physician’s discretion, generally recover to the patient’s baseline condition or Grade 1 or lower prior to resuming this drug.
- If attributable to this drug, resume this drug at the next lower dose following recovery.
Patients take ixazomib by mouth; based on the drug approval study, it should be taken weekly on days 1, 8, and 15 of a 28-day cycle.[rx] The recommended dose is 4 mg, and for patients with moderate or severe hepatic impairment, renal impairment, or need dialysis, this dose is reduced to 3 mg. Ixazomib comes in three different capsule doses, which are 4 mg, 3 mg, and 2.3 mg.[rx]
It is also important to keep in mind that ixazomib should be given with dexamethasone and lenalidomide, which have their specific dosing schedules within a cycle. Both ixazomib and dexamethasone are given on days 1, 8, and 15; hence it is important to separate them since ixazomib should not be taken with food, whereas dexamethasone should be.[rx][rx]
Administration advice:
- Capsules should not be opened or crushed.
- This drug is cytotoxic and direct contact with the capsule contents should be avoided.
- If contact occurs with the skin, wash thoroughly with soap and water.
- If contact occurs with the eyes, flush thoroughly with water.
- Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
- The patient should be advised to read the approved patient labeling.
- If a dose is delayed or missed, the dose should be taken only if the next scheduled dose is 72 hours away or more.
- A missed dose should not be taken within 72 hours of the next scheduled dose.
- A double dose should not be taken to make up for the missed dose.
- If vomiting occurs after taking a dose, the patient should not repeat the dose. The patient should resume dosing at the time of the next scheduled dose.
- Patients should be advised to take this drug exactly as prescribed.
- Patients should be advised to take this drug at least 1 hour before or at least 2 hours after food.
- Patients should be advised that this drug and dexamethasone should not be taken at the same time, because dexamethasone should be taken with food.
- Patients should swallow the capsule whole with water. The capsule should not be crushed, chewed or opened.
- Patients should be advised that direct contact with the capsule contents should be avoided.
- Patients should be advised to wash thoroughly with soap and water If contact occurs with the skin and to flush thoroughly with water If contact occurs with the eyes.
Side Effects
The Most Common
- diarrhea
- constipation
- nausea
- new or worsening rash
- back pain
- unusual swelling of your arms or legs
- weight gain due to swelling
- blurred vision
- dry eyes
- pink eye
- nausea
- extreme tiredness
- loss of appetite
- flu-like symptoms
- unusual bleeding or bruising
- yellowing of your skin or eyes
- pain in the upper right part of your stomach
- burning, tingling, numbness, pain, or weakness in arms or legs
- bloody or black, tarry stool
More common
- Black, tarry stools
- bloating or swelling of the face, arms, hands, lower legs, or feet
- burning, numbness, tingling, or painful sensations
- chills
- cough
- dark urine
- diarrhea
- dizziness
- fever
- headache
- itching or rash
- light-colored stools
- loss of appetite
- lower back or side pain
- nausea
- numbness, tingling, or pain in the hands or feet
- painful or difficult urination
- pale skin
- rapid weight gain
- rash with flat lesions or small raised lesions on the skin
- redness or discoloration of the skin
- sore throat
- stomach pain
- tingling of the hands or feet
- ulcers, sores, or white spots in the mouth
- unpleasant breath odor
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- vomiting of blood
- weakness in the arms, hands, legs, or feet
- yellow eyes or skin
Rare
- Bleeding gums
- blood in the urine or stools
- pinpoint red spots on the skin
- Blistering, peeling, or loosening of the skin
- bloody nose
- heavier menstrual periods
- joint or muscle pain
- red skin lesions, often with a purple center
- red, irritated eyes
- Back pain
- blurred vision
- body aches or pain
- burning, dry, or itching eyes
- difficulty having a bowel movement (stool)
- discharge, excessive tearing
- ear congestion
- loss of voice
- nasal congestion
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- sneezing
Drug Interaction
| DRUG | INTERACTION |
|---|---|
| Abacavir | Abacavir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Abametapir | The serum concentration of Ixazomib can be increased when it is combined with Abametapir. |
| Abatacept | The metabolism of Ixazomib can be increased when combined with Abatacept. |
| Acalabrutinib | The metabolism of Ixazomib can be decreased when combined with Acalabrutinib. |
| Aceclofenac | Aceclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Acemetacin | Acemetacin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Acetaminophen | The metabolism of Ixazomib can be increased when combined with Acetaminophen. |
| Acetazolamide | The metabolism of Ixazomib can be decreased when combined with Acetazolamide. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Aclidinium | Aclidinium may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Acrivastine | Acrivastine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Adalimumab | The metabolism of Ixazomib can be increased when combined with Adalimumab. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Albendazole | The metabolism of Ixazomib can be decreased when combined with Albendazole. |
| Albutrepenona | Ixazomib may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. |
| Alclofenac | Alclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Aldesleukin | The metabolism of Ixazomib can be decreased when combined with Aldesleukin. |
| Allopurinol | Allopurinol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Almasilate | Ixazomib may decrease the excretion rate of Almasilate which could result in a higher serum level. |
| Almotriptan | Almotriptan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Alogliptin | Alogliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Alpelisib | The metabolism of Ixazomib can be increased when combined with Alpelisib. |
| Alprazolam | Alprazolam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amantadine | Amantadine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amikacin | Ixazomib may decrease the excretion rate of Amikacin which could result in a higher serum level. |
| Amiloride | Amiloride may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Aminoglutethimide | The metabolism of Ixazomib can be increased when combined with Aminoglutethimide. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amiodarone | The metabolism of Ixazomib can be decreased when combined with Amiodarone. |
| Amitriptyline | Amitriptyline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ammonium chloride | Ammonium chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amobarbital | The metabolism of Ixazomib can be increased when combined with Amobarbital. |
| Amoxicillin | Amoxicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amphetamine | Amphetamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ampicillin | Ampicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Amprenavir | The metabolism of Ixazomib can be decreased when combined with Amprenavir. |
| Amrinone | Amrinone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Anakinra | The metabolism of Ixazomib can be increased when combined with Anakinra. |
| Ancestim | Ancestim may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Antihemophilic | Antihemophilic factor (recombinant), PEGylated may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Antithrombin III | Ixazomib may decrease the excretion rate of Antithrombin III human which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Apalutamide | The metabolism of Ixazomib can be increased when combined with Apalutamide. |
| Apremilast | The metabolism of Ixazomib can be increased when combined with Apremilast. |
| Aprepitant | The metabolism of Ixazomib can be decreased when combined with Aprepitant. |
| Arformoterol | Arformoterol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Armodafinil | The metabolism of Ixazomib can be increased when combined with Armodafinil. |
| Arsenic trioxide | Arsenic trioxide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Articaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Articaine. |
| Asciminib | The serum concentration of Ixazomib can be increased when it is combined with Asciminib. |
| Astemizole | The metabolism of Ixazomib can be decreased when combined with Astemizole. |
| Asunaprevir | The metabolism of Ixazomib can be increased when combined with Asunaprevir. |
| Atazanavir | The metabolism of Ixazomib can be decreased when combined with Atazanavir. |
| Atomoxetine | Atomoxetine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Auranofin | Auranofin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Aurothioglucose | Aurothioglucose may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Avacopan | The metabolism of Ixazomib can be decreased when combined with Avacopan. |
| Avanafil | The serum concentration of Avanafil can be increased when it is combined with Ixazomib. |
| Azacitidine | Azacitidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Azathioprine | Azathioprine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Azelaic acid | Azelaic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Azithromycin | The metabolism of Ixazomib can be decreased when combined with Azithromycin. |
| Aztreonam | Aztreonam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Baclofen | Baclofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Baricitinib | Ixazomib may decrease the excretion rate of Baricitinib which could result in a higher serum level. |
| Beclomethasone d | The metabolism of Ixazomib can be increased when combined with Beclomethasone dipropionate. |
| Belzutifan | The serum concentration of Ixazomib can be decreased when it is combined with Belzutifan. |
| Bendroflumethi | Bendroflumethiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Benorilate | Benorilate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Benoxaprofen | Benoxaprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Benserazide | Ixazomib may decrease the excretion rate of Benserazide which could result in a higher serum level. |
| Benzatropine | Benzatropine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Benznidazole | Ixazomib may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
| Benzocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Benzocaine. |
| Benzthiazide | Benzthiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Benzydamine | Benzydamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Benzyl alcohol | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Benzyl alcohol. |
| Bepotastine | Bepotastine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Berotralstat | The serum concentration of Ixazomib can be increased when it is combined with Berotralstat. |
| Betamethasone | The metabolism of Ixazomib can be increased when combined with Betamethasone. |
| Betamethasone | The metabolism of Ixazomib can be increased when combined with Betamethasone phosphate. |
| Bexarotene | The metabolism of Ixazomib can be increased when combined with Bexarotene. |
| Bicalutamide | The metabolism of Ixazomib can be decreased when combined with Bicalutamide. |
| Bicisate | Ixazomib may decrease the excretion rate of Bicisate which could result in a higher serum level. |
| Bifonazole | The metabolism of Ixazomib can be decreased when combined with Bifonazole. |
| Bimekizumab | The metabolism of Ixazomib can be increased when combined with Bimekizumab. |
| Bismuth sub | Ixazomib may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. |
| Bisoprolol | Bisoprolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Bisoxatin | Bisoxatin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Bleomycin | Bleomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Boceprevir | The metabolism of Ixazomib can be decreased when combined with Boceprevir. |
| Bosentan | The metabolism of Ixazomib can be increased when combined with Bosentan. |
| Bosutinib | The metabolism of Ixazomib can be decreased when combined with Bosutinib. |
| Brentuximab ve | The metabolism of Ixazomib can be decreased when combined with Brentuximab vedotin. |
| Brivaracetam | Brivaracetam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Bromazepam | Bromazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Bromotheophy | Bromotheophylline may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Budesonide | The metabolism of Ixazomib can be increased when combined with Budesonide. |
| Bumadizone | Bumadizone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Bumetanide | Bumetanide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Bupivacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Bupivacaine. |
| Buprenorphine | The metabolism of Ixazomib can be decreased when combined with Buprenorphine. |
| Bupropion | Bupropion may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Buspirone | Buspirone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Butabarbital | Butabarbital may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Butacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Butacaine. |
| Butalbital | The metabolism of Ixazomib can be increased when combined with Butalbital. |
| Butamben | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Butamben. |
| Calcitriol | The metabolism of Ixazomib can be increased when combined with Calcitriol. |
| Canagliflozin | Canagliflozin may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Canakinumab | The metabolism of Ixazomib can be increased when combined with Canakinumab. |
| Candicidin | The metabolism of Ixazomib can be decreased when combined with Candicidin. |
| Cannabidiol | The metabolism of Ixazomib can be decreased when combined with Cannabidiol. |
| Canrenoic acid | Canrenoic acid may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Capecitabine | Capecitabine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Capreomycin | Ixazomib may decrease the excretion rate of Capreomycin which could result in a higher serum level. |
| Capsaicin | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Capsaicin. |
| Carbamazepine | The metabolism of Ixazomib can be increased when combined with Carbamazepine. |
| Carbidopa | Carbidopa may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Carmustine | Carmustine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefdinir | Cefdinir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefpirome | Cefpirome may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefradine | The metabolism of Ixazomib can be increased when combined with Cefradine. |
| Ceftaroline fosamil | Ceftaroline fosamil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceftobiprole | Ceftobiprole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceftolozane | Ceftolozane may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cenobamate | The serum concentration of Ixazomib can be decreased when it is combined with Cenobamate. |
| Cephalexin | The metabolism of Ixazomib can be decreased when combined with Cephalexin. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ceritinib | The metabolism of Ixazomib can be decreased when combined with Ceritinib. |
| Cerivastatin | The metabolism of Ixazomib can be increased when combined with Cerivastatin. |
| Certolizumab pegol | The metabolism of Ixazomib can be increased when combined with Certolizumab pegol. |
| Cetirizine | Cetirizine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cevimeline | Cevimeline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Chloral hydrate | Chloral hydrate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Chloramphenicol | The metabolism of Ixazomib can be decreased when combined with Chloramphenicol. |
| Chloroprocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Chloroprocaine. |
| Chloroquine | Chloroquine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Chlorothiazide | Chlorothiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Chloroxylenol | Ixazomib may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. |
| Chlorpromazine | The metabolism of Ixazomib can be increased when combined with Chlorpromazine. |
| Chlorpropamide | Chlorpropamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Chlorthalidone | Chlorthalidone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Chlorzoxazone | Chlorzoxazone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Choline C 11 | Choline C 11 may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Choline magnesium | Choline magnesium trisalicylate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Choline salicylate | Ixazomib may decrease the excretion rate of Choline salicylate which could result in a higher serum level. |
| Chondroitin sulfate | Chondroitin sulfate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Chromic chloride | Chromic chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Chromic nitrate | Ixazomib may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. |
| Chromium | Ixazomib may decrease the excretion rate of Chromium which could result in a higher serum level. |
| Chromium gluco | Ixazomib may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. |
| Chromium nicotin | Ixazomib may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. |
| Chromous sulfate | Ixazomib may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cilostazol | Cilostazol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cimetidine | The metabolism of Ixazomib can be decreased when combined with Cimetidine. |
| Cinchocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Cinchocaine. |
| Ciprofloxacin | The metabolism of Ixazomib can be decreased when combined with Ciprofloxacin. |
| Cisapride | The metabolism of Ixazomib can be decreased when combined with Cisapride. |
| Cisplatin | Ixazomib may decrease the excretion rate of Cisplatin which could result in a higher serum level. |
| Citalopram | The metabolism of Ixazomib can be decreased when combined with Citalopram. |
| Clarithromycin | The metabolism of Ixazomib can be decreased when combined with Clarithromycin. |
| Clevidipine | The metabolism of Ixazomib can be increased when combined with Clevidipine. |
| Clobazam | The metabolism of Ixazomib can be increased when combined with Clobazam. |
| Clobetasol propio | The metabolism of Ixazomib can be increased when combined with Clobetasol propionate. |
| Clofarabine | Clofarabine may decre |
| Clofazimine | The metabolism of Ixazomib can be decreased when combined with Clofazimine. |
| Clofibrate | The metabolism of Ixazomib can be increased when combined with Clofibrate. |
| Clomipramine | Clomipramine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Clonazepam | Clonazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Clorazepic acid | Clorazepic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Clove oil | Ixazomib may decrease the excretion rate of Clove oil which could result in a higher serum level. |
| Clozapine | The metabolism of Ixazomib can be increased when combined with Clozapine. |
| Cobicistat | The metabolism of Ixazomib can be decreased when combined with Cobicistat. |
| Cobimetinib | The metabolism of Ixazomib can be decreased when combined with Cobimetinib. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Cocaine. |
| Colchicine | Colchicine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Colistin | Ixazomib may decrease the excretion rate of Colistin which could result in a higher serum level. |
| Conivaptan | The metabolism of Ixazomib can be decreased when combined with Conivaptan. |
| Conjugated | Conjugated estrogens may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Corifollitropin alfa | Corifollitropin alfa may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Corticotropin | The metabolism of Ixazomib can be increased when combined with Corticotropin. |
| Cortisone acetate | The metabolism of Ixazomib can be increased when combined with Cortisone acetate. |
| Crizotinib | The metabolism of Ixazomib can be decreased when combined with Crizotinib. |
| Curcumin | The metabolism of Ixazomib can be decreased when combined with Curcumin. |
| Cyanocobalamin | Cyanocobalamin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Cyclopenthiazide | Cyclopenthiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Cyclophosphamide | The metabolism of Ixazomib can be increased when combined with Cyclophosphamide. |
| Cyclosporine | The metabolism of Ixazomib can be decreased when combined with Cyclosporine. |
| Cyclothiazide | Cyclothiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Cyproterone acetate | The metabolism of Ixazomib can be decreased when combined with Cyproterone acetate. |
| Dabigatran etexilate | Dabigatran etexilate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dabrafenib | The serum concentration of Ixazomib can be decreased when it is combined with Dabrafenib. |
| Dacarbazine | Dacarbazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dacomitinib | The metabolism of Ixazomib can be decreased when combined with Dacomitinib. |
| Dalfampridine | Dalfampridine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dalfopristin | The metabolism of Ixazomib can be decreased when combined with Dalfopristin. |
| Danazol | The metabolism of Ixazomib can be decreased when combined with Danazol. |
| Dapagliflozin | Dapagliflozin may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Daptomycin | Daptomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Darbepoetin alfa | The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Ixazomib. |
| Darunavir | The serum concentration of Ixazomib can be increased when it is combined with Darunavir. |
| Dasatinib | The metabolism of Ixazomib can be decreased when combined with Dasatinib. |
| Daunorubicin | The metabolism of Ixazomib can be decreased when combined with Daunorubicin. |
| Deferasirox | The metabolism of Ixazomib can be increased when combined with Deferasirox. |
| Deferiprone | Deferiprone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Deflazacort | The metabolism of Ixazomib can be increased when combined with Deflazacort. |
| Delafloxacin | Ixazomib may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
| Delavirdine | The metabolism of Ixazomib can be decreased when combined with Delavirdine. |
| Desipramine | The metabolism of Ixazomib can be decreased when combined with Desipramine. |
| Desmopressin | Desmopressin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Desvenlafaxine | The metabolism of Ixazomib can be decreased when combined with Desvenlafaxine. |
| Deutetrabenazine | Ixazomib may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level. |
| Dexamethasone | The metabolism of Ixazomib can be increased when combined with Dexamethasone. |
| Dexamethasone | The metabolism of Ixazomib can be increased when combined with Dexamethasone acetate. |
| Dexibuprofen | Dexibuprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dexketoprofen | Dexketoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dexmedetomidine | Dexmedetomidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dexpanthenol | Dexpanthenol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dexrazoxane | Dexrazoxane may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dextran | Dextran may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dextropropox | The metabolism of Ixazomib can be decreased when combined with Dextropropoxyphene. |
| Diatrizoate | Diatrizoate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Diazepam | Diazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dichlorobenzyl a | Ixazomib may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Diclofenamide | Diclofenamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Dicloxacillin | The metabolism of Ixazomib can be increased when combined with Dicloxacillin. |
| Dicyclomine | Dicyclomine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Didanosine | Didanosine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dienogest | Dienogest may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Diethylstilbestrol | The metabolism of Ixazomib can be decreased when combined with Diethylstilbestrol. |
| Diflunisal | Diflunisal may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Difluocortolone | The metabolism of Ixazomib can be increased when combined with Difluocortolone. |
| Digoxin | Ixazomib may decrease the excretion rate of Digoxin which could result in a higher serum level. |
| Dihydroergocornine | The metabolism of Ixazomib can be decreased when combined with Dihydroergocornine. |
| Dihydroergocristine | The metabolism of Ixazomib can be decreased when combined with Dihydroergocristine. |
| Dihydroergotamine | The metabolism of Ixazomib can be decreased when combined with Dihydroergotamine. |
| Dihydrostreptomycin | Dihydrostreptomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Diltiazem | The metabolism of Ixazomib can be decreased when combined with Diltiazem. |
| Dimercaprol | Dimercaprol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dimethyl sulfoxide | The metabolism of Ixazomib can be decreased when combined with Dimethyl sulfoxide. |
| Diosmin | The metabolism of Ixazomib can be decreased when combined with Diosmin. |
| Diphenhydramine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Diphenhydramine. |
| Disopyramide | Disopyramide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| DL-Methylephedrine | Ixazomib may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level. |
| Dobutamine | Dobutamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Docetaxel | The metabolism of Ixazomib can be decreased when combined with Docetaxel. |
| Dopamine | Dopamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Doripenem | Doripenem may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Doxacurium | Doxacurium may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Doxazosin | The metabolism of Ixazomib can be decreased when combined with Doxazosin. |
| Doxepin | Doxepin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Doxorubicin | The metabolism of Ixazomib can be decreased when combined with Doxorubicin. |
| Doxycycline | Doxycycline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Dronedarone | The serum concentration of Ixazomib can be increased when it is combined with Dronedarone. |
| Drospirenone | The metabolism of Ixazomib can be decreased when combined with Drospirenone. |
| Droxidopa | Droxidopa may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Duloxetine | Duloxetine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Duvelisib | The metabolism of Ixazomib can be decreased when combined with Duvelisib. |
| Dyclonine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Dyclonine. |
| Dyphylline | Dyphylline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ebastine | The metabolism of Ixazomib can be decreased when combined with Ebastine. |
| Echinacea | The metabolism of Ixazomib can be increased when combined with Echinacea. |
| Edoxaban | Edoxaban may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Edrophonium | Edrophonium may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Efavirenz | The metabolism of Ixazomib can be decreased when combined with Efavirenz. |
| Elexacaftor | The metabolism of Ixazomib can be decreased when combined with Elexacaftor. |
| Elvitegravir | The metabolism of Ixazomib can be decreased when combined with Elvitegravir. |
| Emapalumab | The metabolism of Ixazomib can be increased when combined with Emapalumab. |
| Enalaprilat | Enalaprilat may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Enasidenib | The metabolism of Ixazomib can be increased when combined with Enasidenib. |
| Enzalutamide | The serum concentration of Ixazomib can be decreased when it is combined with Enzalutamide. |
| Epinephrine | The metabolism of Ixazomib can be decreased when combined with Epinephrine. |
| Eplerenone | Eplerenone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Epoprostenol | Epoprostenol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ergotamine | The metabolism of Ixazomib can be decreased when combined with Ergotamine. |
| Erlotinib | The metabolism of Ixazomib can be decreased when combined with Erlotinib. |
| Ertapenem | Ertapenem may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ertugliflozin | Ertugliflozin may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Erythromycin | The metabolism of Ixazomib can be decreased when combined with Erythromycin. |
| Erythropoietin | The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Ixazomib. |
| Esketamine | The metabolism of Ixazomib can be increased when combined with Esketamine. |
| Eslicarbazepine | The metabolism of Ixazomib can be increased when combined with Eslicarbazepine. |
| Eslicarbazepine | The metabolism of Ixazomib can be increased when combined with Eslicarbazepine acetate. |
| Estazolam | Estazolam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Estetrol | The metabolism of Ixazomib can be decreased when combined with Estetrol. |
| Estradiol | Estradiol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Estradiol acetate | The metabolism of Ixazomib can be increased when combined with Estradiol acetate. |
| Estradiol benzoate | The metabolism of Ixazomib can be increased when combined with Estradiol benzoate. |
| Estradiol cypionate | The metabolism of Ixazomib can be increased when combined with Estradiol cypionate. |
| Estradiol dienanthate | The metabolism of Ixazomib can be increased when combined with Estradiol dienanthate. |
| Estradiol valerate | The metabolism of Ixazomib can be increased when combined with Estradiol valerate. |
| Estrone sulfate | Estrone sulfate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Eszopiclone | Eszopiclone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Etacrynic acid | Etacrynic acid may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Etafedrine | Ixazomib may decrease the excretion rate of Etafedrine which could result in a higher serum level. |
| Etanercept | The metabolism of Ixazomib can be increased when combined with Etanercept. |
| Ethambutol | The metabolism of Ixazomib can be decreased when combined with Ethambutol. |
| Ethanol | The metabolism of Ixazomib can be increased when combined with Ethanol. |
| Ethyl chloride | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Ethyl chloride. |
| Etidocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Etidocaine. |
| Etodolac | Etodolac may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Etomidate | Etomidate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Etonogestrel | Etonogestrel may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Etoricoxib | The metabolism of Ixazomib can be decreased when combined with Etoricoxib. |
| Etravirine | The metabolism of Ixazomib can be increased when combined with Etravirine. |
| Eucalyptus oil | Ixazomib may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. |
| Ezogabine | Ezogabine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Felbamate | The metabolism of Ixazomib can be increased when combined with Felbamate. |
| Fenbufen | Fenbufen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fenofibrate | The metabolism of Ixazomib can be decreased when combined with Fenofibrate. |
| Fenofibric acid | Ixazomib may decrease the excretion rate of Fenofibric acid which could result in a higher serum level. |
| Fenoldopam | Fenoldopam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fentanyl | Fentanyl may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fesoterodine | Fesoterodine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fexinidazole | The metabolism of Ixazomib can be decreased when combined with Fexinidazole. |
| Finerenone | Finerenone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Flavoxate | Flavoxate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Floctafenine | Floctafenine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Florbetaben (18F) | Florbetaben (18F) may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Florbetapir (18F) | Florbetapir (18F) may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Floxuridine | Floxuridine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Flucloxacillin | The metabolism of Ixazomib can be increased when combined with Flucloxacillin. |
| Fluconazole | The metabolism of Ixazomib can be decreased when combined with Fluconazole. |
| Flucytosine | Flucytosine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fludeoxyglucose | Fludeoxyglucose (18F) may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Flumazenil | Flumazenil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Flunisolide | The metabolism of Ixazomib can be increased when combined with Flunisolide. |
| Fluocinolone a | The metabolism of Ixazomib can be increased when combined with Fluocinolone acetonide. |
| Fluocinonide | The metabolism of Ixazomib can be increased when combined with Fluocinonide. |
| Fluocortolone | The metabolism of Ixazomib can be increased when combined with Fluocortolone. |
| Fluoxetine | The metabolism of Ixazomib can be decreased when combined with Fluoxetine. |
| Flurazepam | Flurazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Flutamide | Flutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fluticasone | The metabolism of Ixazomib can be increased when combined with Fluticasone. |
| Fluticasone p | The metabolism of Ixazomib can be decreased when combined with Fluticasone propionate. |
| Fluvoxamine | The metabolism of Ixazomib can be decreased when combined with Fluvoxamine. |
| Folic acid | Folic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fomepizole | Fomepizole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fondaparinux | Fondaparinux may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Formestane | The metabolism of Ixazomib can be increased when combined with Formestane. |
| Fosamprenavir | The metabolism of Ixazomib can be decreased when combined with Fosamprenavir. |
| Fosaprepitant | The metabolism of Ixazomib can be increased when combined with Fosaprepitant. |
| Foscarnet | Foscarnet may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fosfomycin | Fosfomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fosinopril | Fosinopril may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Fosnetupitant | The metabolism of Ixazomib can be decreased when combined with Fosnetupitant. |
| Fosphenytoin | The metabolism of Ixazomib can be increased when combined with Fosphenytoin. |
| Fostamatinib | The metabolism of Ixazomib can be decreased when combined with Fostamatinib. |
| Framycetin | Framycetin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Furosemide | Furosemide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Fusidic acid | The metabolism of Ixazomib can be decreased when combined with Fusidic acid. |
| Gabapentin enac | Gabapentin enacarbil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gadobenic acid | Gadobenic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gadodiamide | Gadodiamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gadofosveset trisodium | Gadofosveset trisodium may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gadopentetic acid | Gadopentetic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gadoteric acid | Gadoteric acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gadoteridol | Gadoteridol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ganciclovir | Ganciclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gemcitabine | Gemcitabine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gemfibrozil | Gemfibrozil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Gentamicin | Ixazomib may decrease the excretion rate of Gentamicin which could result in a higher serum level. |
| Gilteritinib | The metabolism of Ixazomib can be decreased when combined with Gilteritinib. |
| Gimeracil | Gimeracil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ginkgo biloba | The metabolism of Ixazomib can be decreased when combined with Ginkgo biloba. |
| Givosiran | Givosiran may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Glecaprevir | The metabolism of Ixazomib can be decreased when combined with Glecaprevir. |
| Glipizide | Glipizide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Glyburide | The metabolism of Ixazomib can be decreased when combined with Glyburide. |
| Glycerol phenyl | The metabolism of Ixazomib can be increased when combined with Glycerol phenylbutyrate. |
| Golimumab | The metabolism of Ixazomib can be increased when combined with Golimumab. |
| Golodirsen | Ixazomib may decrease the excretion rate of Golodirsen which could result in a higher serum level. |
| Goserelin | Goserelin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Griseofulvin | The metabolism of Ixazomib can be increased when combined with Griseofulvin. |
| Guanethidine | Guanethidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Guanfacine | Guanfacine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Ixazomib. |
| Hydralazine | The metabolism of Ixazomib can be decreased when combined with Hydralazine. |
| Hydrochlorothiazide | Hydrochlorothiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Hydrocortamate | The metabolism of Ixazomib can be increased when combined with Hydrocortamate. |
| Hydrocortisone | The metabolism of Ixazomib can be increased when combined with Hydrocortisone. |
| Hydrocortisone a | The metabolism of Ixazomib can be increased when combined with Hydrocortisone acetate. |
| Hydrocortisone | The metabolism of Ixazomib can be increased when combined with Hydrocortisone butyrate. |
| Hydrocortisone | The metabolism of Ixazomib can be increased when combined with Hydrocortisone succinate. |
| Hydroflumethiazide | Hydroflumethiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Hydromorphone | Hydromorphone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Hydroxocobalamin | Hydroxocobalamin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Hydroxyethyl Starch | Hydroxyethyl Starch may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ibutilide | Ibutilide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Icatibant | Icatibant may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Idarucizumab | Idarucizumab may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Idebenone | Idebenone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Idelalisib | The metabolism of Ixazomib can be decreased when combined with Idelalisib. |
| Ifosfamide | The metabolism of Ixazomib can be increased when combined with Ifosfamide. |
| Imatinib | The serum concentration of Ixazomib can be increased when it is combined with Imatinib. |
| Imipramine | Imipramine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Indapamide | Indapamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Indigotindisulfonic | Ixazomib may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level. |
| Indinavir | The metabolism of Ixazomib can be decreased when combined with Indinavir. |
| Indomethacin | Indomethacin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Infigratinib | The metabolism of Ixazomib can be decreased when combined with Infigratinib. |
| Infliximab | The metabolism of Ixazomib can be increased when combined with Infliximab. |
| Inosine pranobex | Ixazomib may decrease the excretion rate of Inosine pranobex which could result in a higher serum level. |
| Inositol | Ixazomib may decrease the excretion rate of Inositol which could result in a higher serum level. |
| Inotersen | Inotersen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Iobenguane sulfa | Iobenguane sulfate I-123 may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Iodixanol | Iodixanol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ioflupane I-123 | Ioflupane I-123 may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Iopromide | Iopromide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Iothalamic acid | Iothalamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ioversol | Ioversol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ioxilan | Ioxilan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ipecac | Ixazomib may decrease the excretion rate of Ipecac which could result in a higher serum level. |
| Ipilimumab | Ipilimumab may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Irbesartan | The metabolism of Ixazomib can be decreased when combined with Irbesartan. |
| Isavuconazole | The metabolism of Ixazomib can be increased when combined with Isavuconazole. |
| Isavuconazonium | The metabolism of Ixazomib can be increased when combined with Isavuconazonium. |
| Isoniazid | The metabolism of Ixazomib can be decreased when combined with Isoniazid. |
| Isosorbide | Isosorbide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Isosorbide mon | Isosorbide mononitrate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Isosulfan blue | Isosulfan blue may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Isotretinoin | Isotretinoin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Isoxicam | Isoxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Isradipine | The metabolism of Ixazomib can be decreased when combined with Isradipine. |
| Itraconazole | The metabolism of Ixazomib can be decreased when combined with Itraconazole. |
| Ivacaftor | The metabolism of Ixazomib can be decreased when combined with Ivacaftor. |
| Ivosidenib | The metabolism of Ixazomib can be increased when combined with Ivosidenib. |
| Kanamycin | Ixazomib may decrease the excretion rate of Kanamycin which could result in a higher serum level. |
| Ketamine | Ketamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ketazolam | The metabolism of Ixazomib can be decreased when combined with Ketazolam. |
| Ketoconazole | The metabolism of Ixazomib can be decreased when combined with Ketoconazole. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Labetalol | Labetalol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lacosamide | The metabolism of Ixazomib can be decreased when combined with Lacosamide. |
| Lamivudine | Lamivudine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lamotrigine | Lamotrigine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lanreotide | The metabolism of Ixazomib can be decreased when combined with Lanreotide. |
| Lapatinib | The metabolism of Ixazomib can be decreased when combined with Lapatinib. |
| Latamoxef | Latamoxef may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ledipasvir | Ledipasvir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lefamulin | The serum concentration of Ixazomib can be increased when it is combined with Lefamulin. |
| Lenalidomide | Lenalidomide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lesinurad | The metabolism of Ixazomib can be increased when combined with Lesinurad. |
| Letermovir | The metabolism of Ixazomib can be decreased when combined with Letermovir. |
| Leuprolide | Leuprolide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Levobupivacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Levobupivacaine. |
| Levocarnitine | Levocarnitine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Levocetirizine | Levocetirizine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Levofloxacin | Levofloxacin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Levoketoconazole | The metabolism of Ixazomib can be decreased when combined with Levoketoconazole. |
| Levomilnacipran | Levomilnacipran may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Levosalbutamol | Ixazomib may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. |
| Lidocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Lidocaine. |
| Linagliptin | The metabolism of Ixazomib can be decreased when combined with Linagliptin. |
| Liothyronine | Liothyronine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lisinopril | Lisinopril may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lithium carbonate | Ixazomib may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. |
| Lithium citrate | Lithium citrate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lixisenatide | Lixisenatide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lofexidine | Lofexidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lomitapide | The metabolism of Ixazomib can be decreased when combined with Lomitapide. |
| Lonafarnib | The metabolism of Ixazomib can be decreased when combined with Lonafarnib. |
| Lopinavir | The metabolism of Ixazomib can be decreased when combined with Lopinavir. |
| Loracarbef | Loracarbef may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lorazepam | Lorazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lorcaserin | Lorcaserin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lorlatinib | The metabolism of Ixazomib can be increased when combined with Lorlatinib. |
| Lornoxicam | Lornoxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lorpiprazole | Lorpiprazole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Losartan | The metabolism of Ixazomib can be decreased when combined with Losartan. |
| Lovastatin | The metabolism of Ixazomib can be decreased when combined with Lovastatin. |
| Loxoprofen | Loxoprofen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lubiprostone | Lubiprostone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Lumacaftor | The metabolism of Ixazomib can be increased when combined with Lumacaftor. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Macitentan | Macitentan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Magnesium carbo | Magnesium carbonate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Magnesium chloride | Magnesium chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Magnesium hyd | Magnesium hydroxide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Magnesium tris | Magnesium trisilicate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Mangafodipir | Mangafodipir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Manidipine | The metabolism of Ixazomib can be decreased when combined with Manidipine. |
| Mannitol | Mannitol may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Maprotiline | Maprotiline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Mavacamten | The serum concentration of Ixazomib can be decreased when it is combined with Mavacamten. |
| Mecamylamine | Mecamylamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Medroxyprogester | The metabolism of Ixazomib can be increased when combined with Medroxyprogesterone acetate. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Megestrol acetate | Megestrol acetate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Meloxicam. |
| Memantine | Memantine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Meperidine | The metabolism of Ixazomib can be decreased when combined with Meperidine. |
| Mepivacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Mepivacaine. |
| Meprednisone | The metabolism of Ixazomib can be increased when combined with Meprednisone. |
| Meropenem | Meropenem may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Metamfetamine | Metamfetamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Metamizole | Metamizole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Metaxalone | Metaxalone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Metformin | Metformin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Methadone | The metabolism of Ixazomib can be decreased when combined with Methadone. |
| Methazolamide | Methazolamide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Methimazole | The metabolism of Ixazomib can be decreased when combined with Methimazole. |
| Methotrexate | Methotrexate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Methoxsalen | Methoxsalen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Methoxy | The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Ixazomib. |
| Methyldopa | Methyldopa may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Methylene blue | The metabolism of Ixazomib can be decreased when combined with Methylene blue. |
| Methylergometrine | The metabolism of Ixazomib can be decreased when combined with Methylergometrine. |
| Methylnaltrexone | Methylnaltrexone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Methylphenobarbital | The metabolism of Ixazomib can be increased when combined with Methylphenobarbital. |
| Methylprednisolone | The metabolism of Ixazomib can be increased when combined with Methylprednisolone. |
| Methylprednisone | The metabolism of Ixazomib can be decreased when combined with Methylprednisone. |
| Methyltestosterone | Methyltestosterone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Methysergide | The metabolism of Ixazomib can be decreased when combined with Methysergide. |
| Meticrane | Meticrane may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Metoclopramide | Metoclopramide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Metolazone | Metolazone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Metoprolol | Metoprolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Metreleptin | The metabolism of Ixazomib can be increased when combined with Metreleptin. |
| Metronidazole | The metabolism of Ixazomib can be decreased when combined with Metronidazole. |
| Metyrapone | The metabolism of Ixazomib can be increased when combined with Metyrapone. |
| Miconazole | The metabolism of Ixazomib can be decreased when combined with Miconazole. |
| Midazolam | The metabolism of Ixazomib can be decreased when combined with Midazolam. |
| Midostaurin | The metabolism of Ixazomib can be decreased when combined with Midostaurin. |
| Mifepristone | The metabolism of Ixazomib can be increased when combined with Mifepristone. |
| Migalastat | Migalastat may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Milnacipran | The metabolism of Ixazomib can be decreased when combined with Milnacipran. |
| Milrinone | Milrinone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Miocamycin | The metabolism of Ixazomib can be decreased when combined with Miocamycin. |
| Mirabegron | Mirabegron may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Mirtazapine | The metabolism of Ixazomib can be decreased when combined with Mirtazapine. |
| Mitapivat | The metabolism of Ixazomib can be increased when combined with Mitapivat. |
| Mitotane | The metabolism of Ixazomib can be increased when combined with Mitotane. |
| Mobocertinib | The serum concentration of Ixazomib can be decreased when it is combined with Mobocertinib. |
| Modafinil | The metabolism of Ixazomib can be increased when combined with Modafinil. |
| Mometasone fur | The metabolism of Ixazomib can be increased when combined with Mometasone furoate. |
| Mosunetuzumab | The metabolism of Ixazomib can be decreased when combined with Mosunetuzumab. |
| Moxisylyte | Moxisylyte may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Muzolimine | Muzolimine may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Mycophenolate | Mycophenolate mofetil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Mycophenolic acid | Mycophenolic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| N-acetyltyrosine | Ixazomib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nadolol | Nadolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nafcillin | The metabolism of Ixazomib can be increased when combined with Nafcillin. |
| Naldemedine | Ixazomib may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
| Nalmefene | Nalmefene may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Naloxone | Naloxone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nateglinide | Nateglinide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nedaplatin | Ixazomib may decrease the excretion rate of Nedaplatin which could result in a higher serum level. |
| Nedocromil | Nedocromil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nefazodone | The metabolism of Ixazomib can be decreased when combined with Nefazodone. |
| Nelfinavir | The metabolism of Ixazomib can be decreased when combined with Nelfinavir. |
| Neomycin | Ixazomib may decrease the excretion rate of Neomycin which could result in a higher serum level. |
| Netilmicin | Ixazomib may decrease the excretion rate of Netilmicin which could result in a higher serum level. |
| Netupitant | The metabolism of Ixazomib can be decreased when combined with Netupitant. |
| Niacin | The metabolism of Ixazomib can be decreased when combined with Niacin. |
| Nicardipine | The metabolism of Ixazomib can be decreased when combined with Nicardipine. |
| Nicorandil | Nicorandil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nifedipine | Nifedipine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nilotinib | The metabolism of Ixazomib can be decreased when combined with Nilotinib. |
| Nilutamide | Nilutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nilvadipine | The metabolism of Ixazomib can be decreased when combined with Nilvadipine. |
| Nimesulide | Nimesulide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nintedanib | The metabolism of Ixazomib can be decreased when combined with Nintedanib. |
| Nisoldipine | Nisoldipine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nitric Oxide | Nitric Oxide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nitrofurantoin | Nitrofurantoin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Nitroprusside | Nitroprusside may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Norethisterone | The metabolism of Ixazomib can be decreased when combined with Norethisterone. |
| Norgestimate | The metabolism of Ixazomib can be increased when combined with Norgestimate. |
| Noscapine | The metabolism of Ixazomib can be decreased when combined with Noscapine. |
| Octinoxate | Octinoxate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Octreotide | The serum concentration of Ixazomib can be increased when it is combined with Octreotide. |
| Olaparib | The metabolism of Ixazomib can be decreased when combined with Olaparib. |
| Olsalazine | Olsalazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Opium | Ixazomib may decrease the excretion rate of Opium which could result in a higher serum level. |
| Oritavancin | The metabolism of Ixazomib can be increased when combined with Oritavancin. |
| Orphenadrine | The metabolism of Ixazomib can be decreased when combined with Orphenadrine. |
| Oseltamivir | Oseltamivir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Osilodrostat | The metabolism of Ixazomib can be decreased when combined with Osilodrostat. |
| Osimertinib | The metabolism of Ixazomib can be decreased when combined with Osimertinib. |
| Oxacillin | Oxacillin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Oxazepam | Oxazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Oxcarbazepine | The metabolism of Ixazomib can be increased when combined with Oxcarbazepine. |
| Oxetacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Oxetacaine. |
| Oxybenzone | Oxybenzone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Oxybuprocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Oxybuprocaine. |
| Oxybutynin | The metabolism of Ixazomib can be decreased when combined with Oxybutynin. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Oxyquinoline | Ixazomib may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. |
| Paclitaxel | The metabolism of Ixazomib can be increased when combined with Paclitaxel. |
| Pacritinib | The serum concentration of Ixazomib can be increased when it is combined with Pacritinib. |
| Palbociclib | The metabolism of Ixazomib can be decreased when combined with Palbociclib. |
| Paliperidone | Paliperidone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Palonosetron | Palonosetron may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pantoprazole | Pantoprazole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Parecoxib | Parecoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Paromomycin | Paromomycin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pasireotide | The metabolism of Ixazomib can be decreased when combined with Pasireotide. |
| Patent Blue | Ixazomib may decrease the excretion rate of Patent Blue which could result in a higher serum level. |
| Pazopanib | The metabolism of Ixazomib can be decreased when combined with Pazopanib. |
| Pegaptanib | Pegaptanib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Peginesatide | The risk or severity of Thrombosis can be increased when Peginesatide is combined with Ixazomib. |
| Pemetrexed | Ixazomib may decrease the excretion rate of Pemetrexed which could result in a higher serum level. |
| Penbutolol | Penbutolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pentaerythritol t | Pentaerythritol tetranitrate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pentastarch | Pentastarch may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pentetic acid | Ixazomib may decrease the excretion rate of Pentetic acid which could result in a higher serum level. |
| Pentobarbital | The metabolism of Ixazomib can be increased when combined with Pentobarbital. |
| Pentostatin | Ixazomib may decrease the excretion rate of Pentostatin which could result in a higher serum level. |
| Pentoxifylline | Pentoxifylline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Perampanel | The metabolism of Ixazomib can be increased when combined with Perampanel. |
| Perindopril | Perindopril may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Permethrin | Permethrin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Phenazopyridine | Phenazopyridine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Phenelzine | Phenelzine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Phenobarbital | The metabolism of Ixazomib can be increased when combined with Phenobarbital. |
| Phenol | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Phenol. |
| Phentolamine | Phentolamine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Phenylbutazone | The metabolism of Ixazomib can be increased when combined with Phenylbutazone. |
| Phenytoin | The metabolism of Ixazomib can be increased when combined with Phenytoin. |
| Pholcodine | Pholcodine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Phosphoric acid | Phosphoric acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Phylloquinone | Phylloquinone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Picosulfuric acid | Picosulfuric acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pimavanserin | The metabolism of Ixazomib can be decreased when combined with Pimavanserin. |
| Pimozide | The metabolism of Ixazomib can be decreased when combined with Pimozide. |
| Pindolol | Pindolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Piperacillin | Piperacillin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Piperaquine | The metabolism of Ixazomib can be decreased when combined with Piperaquine. |
| Piracetam | Piracetam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Piretanide | Piretanide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Piroxicam | Piroxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pitolisant | The serum concentration of Ixazomib can be decreased when it is combined with Pitolisant. |
| Plazomicin | Ixazomib may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
| Plerixafor | Plerixafor may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Polythiazide | Polythiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Pomalidomide | Pomalidomide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Posaconazole | The metabolism of Ixazomib can be decreased when combined with Posaconazole. |
| Potassium | Potassium may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Potassium acetate | Ixazomib may decrease the excretion rate of Potassium acetate which could result in a higher serum level. |
| Potassium bic | Ixazomib may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. |
| Potassium cation | Potassium cation may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Potassium chloride | Potassium chloride may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Potassium citrate | Potassium citrate may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Potassium nitrate | Ixazomib may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. |
| Potassium per | Potassium perchlorate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Potassium sulfate | Ixazomib may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. |
| Pralatrexate | Pralatrexate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pralidoxime | Pralidoxime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pralsetinib | The metabolism of Ixazomib can be increased when combined with Pralsetinib |
| Pramipexole | Pramipexole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pramocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Pramocaine. |
| Prasugrel | Prasugrel may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Prednisolone | The metabolism of Ixazomib can be increased when combined with Prednisolone. |
| Prednisolone ac | The metabolism of Ixazomib can be increased when combined with Prednisolone acetate. |
| Prednisolone | The metabolism of Ixazomib can be increased when combined with Prednisolone phosphate. |
| Prednisone | Prednisone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Prednisone acet | The metabolism of Ixazomib can be increased when combined with Prednisone acetate. |
| Pregabalin | Pregabalin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pretomanid | The metabolism of Ixazomib can be decreased when combined with Pretomanid. |
| Prilocaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Prilocaine. |
| Primaquine | The metabolism of Ixazomib can be decreased when combined with Primaquine. |
| Primidone | The metabolism of Ixazomib can be increased when combined with Primidone. |
| Probenecid | The metabolism of Ixazomib can be increased when combined with Probenecid. |
| Procainamide | Ixazomib may decrease the excretion rate of Procainamide which could result in a higher serum level. |
| Procaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Procaine. |
| Procaine benz | Procaine benzylpenicillin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Promethazine | Promethazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Propantheline | Propantheline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Proparacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Proparacaine. |
| Propiverine | Ixazomib may decrease the excretion rate of Propiverine which could result in a higher serum level. |
| Propofol | The metabolism of Ixazomib can be decreased when combined with Propofol. |
| Propoxycaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Propoxycaine. |
| Propranolol | Propranolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Prucalopride | Prucalopride may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pyrantel | Ixazomib may decrease the excretion rate of Pyrantel which could result in a higher serum level. |
| Pyrazinamide | Pyrazinamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pyridoxine | Pyridoxine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Pyrithione | Pyrithione may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Quetiapine | Quetiapine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Quinethazone | Quinethazone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Quinidine | The metabolism of Ixazomib can be decreased when combined with Quinidine. |
| Quinine | The metabolism of Ixazomib can be increased when combined with Quinine. |
| Quinupristin | The metabolism of Ixazomib can be decreased when combined with Quinupristin. |
| Rabeprazole | Rabeprazole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Raloxifene | The metabolism of Ixazomib can be decreased when combined with Raloxifene. |
| Ramelteon | Ramelteon may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ranitidine | Ranitidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ranolazine | The metabolism of Ixazomib can be decreased when combined with Ranolazine. |
| Rasagiline | Rasagiline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Remdesivir | The metabolism of Ixazomib can be decreased when combined with Remdesivir. |
| Reserpine | Reserpine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Resorcinol | Ixazomib may decrease the excretion rate of Resorcinol which could result in a higher serum level. |
| Ribavirin | Ribavirin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ribociclib | The metabolism of Ixazomib can be decreased when combined with Ribociclib. |
| Ribostamycin | Ixazomib may decrease the excretion rate of Ribostamycin which could result in a higher serum level. |
| Rifabutin | The metabolism of Ixazomib can be increased when combined with Rifabutin. |
| Rifampicin | The metabolism of Ixazomib can be increased when combined with Rifampicin. |
| Rifamycin | The metabolism of Ixazomib can be increased when combined with Rifamycin. |
| Rifapentine | The metabolism of Ixazomib can be increased when combined with Rifapentine. |
| Rilonacept | The metabolism of Ixazomib can be increased when combined with Rilonacept. |
| Rilpivirine | The metabolism of Ixazomib can be decreased when combined with Rilpivirine. |
| Ritonavir | The serum concentration of Ixazomib can be increased when it is combined with Ritonavir. |
| Rivaroxaban | Rivaroxaban may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Rizatriptan | Rizatriptan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Rofecoxib | The metabolism of Ixazomib can be increased when combined with Rofecoxib. |
| Roflumilast | The metabolism of Ixazomib can be decreased when combined with Roflumilast. |
| Ropivacaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Ropivacaine. |
| Rosiglitazone | Rosiglitazone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Rosuvastatin | The metabolism of Ixazomib can be decreased when combined with Rosuvastatin. |
| Roxithromycin | The metabolism of Ixazomib can be decreased when combined with Roxithromycin. |
| Rucaparib | The metabolism of Ixazomib can be decreased when combined with Rucaparib. |
| Rufinamide | The metabolism of Ixazomib can be increased when combined with Rufinamide. |
| Ruxolitinib | Ruxolitinib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sacubitril | Sacubitril may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Salbutamol | Salbutamol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Salicylamide | Salicylamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Salmon calcitonin | Salmon calcitonin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Saquinavir | The metabolism of Ixazomib can be decreased when combined with Saquinavir. |
| Sarilumab | The metabolism of Ixazomib can be increased when combined with Sarilumab. |
| Satralizumab | The serum concentration of Ixazomib can be decreased when it is combined with Satralizumab. |
| Saxagliptin | Saxagliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Secobarbital | The metabolism of Ixazomib can be increased when combined with Secobarbital. |
| Secukinumab | The metabolism of Ixazomib can be increased when combined with Secukinumab. |
| Selenious acid | Ixazomib may decrease the excretion rate of Selenious acid which could result in a higher serum level. |
| Selenium | Ixazomib may decrease the excretion rate of Selenium which could result in a higher serum level. |
| Sibutramine | Sibutramine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Siltuximab | The metabolism of Ixazomib can be increased when combined with Siltuximab. |
| Simeprevir | The metabolism of Ixazomib can be decreased when combined with Simeprevir. |
| Siponimod | The metabolism of Ixazomib can be decreased when combined with Siponimod. |
| Sitagliptin | Sitagliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sitaxentan | The metabolism of Ixazomib can be decreased when combined with Sitaxentan. |
| Sodium acetate | Sodium acetate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sodium auroth | Sodium aurothiomalate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sodium fluoride | Sodium fluoride may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sodium sulfate | Sodium sulfate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sofosbuvir | Sofosbuvir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Solriamfetol | Ixazomib may decrease the excretion rate of Solriamfetol which could result in a higher serum level. |
| Somatostatin | The metabolism of Ixazomib can be decreased when combined with Somatostatin. |
| Somatrogon | The metabolism of Ixazomib can be increased when combined with Somatrogon. |
| Sorafenib | Sorafenib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sorbitol | Sorbitol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sotorasib | The serum concentration of Ixazomib can be decreased when it is combined with Sotorasib. |
| Spironolactone | Spironolactone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| St. John’s Wort | The metabolism of Ixazomib can be increased when combined with St. John’s Wort. |
| Stiripentol | The metabolism of Ixazomib can be decreased when combined with Stiripentol. |
| Streptomycin | Ixazomib may decrease the excretion rate of Streptomycin which could result in a higher serum level. |
| Strontium chloride | Ixazomib may decrease the excretion rate of Strontium chloride which could result in a higher serum level. |
| Sucralfate | Sucralfate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sulbactam | Sulbactam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sulfadiazine | Sulfadiazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sulfamethoxazole | The metabolism of Ixazomib can be decreased when combined with Sulfamethoxazole. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sulfinpyrazone | The metabolism of Ixazomib can be increased when combined with Sulfinpyrazone. |
| Sulindac | Sulindac may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sumatriptan | Sumatriptan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Suvorexant | The metabolism of Ixazomib can be decreased when combined with Suvorexant. |
| Sy Estrogens, A | Synthetic Conjugated Estrogens, A may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Sy Estrogens, B | Synthetic Conjugated Estrogens, B may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tacrolimus | The metabolism of Ixazomib can be decreased when combined with Tacrolimus. |
| Tadalafil | Tadalafil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tamoxifen | The metabolism of Ixazomib can be increased when combined with Tamoxifen. |
| Tamsulosin | Tamsulosin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tasimelteon | The metabolism of Ixazomib can be decreased when combined with Tasimelteon. |
| Tazemetostat | The metabolism of Ixazomib can be decreased when combined with Tazemetostat. |
| Technetium Tc-99m | Technetium Tc-99m exametazime may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Technetium Tc | Technetium Tc-99m mebrofenin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Technetium | Technetium Tc-99m oxidronate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Technetium | Technetium Tc-99m pyrophosphate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tecovirimat | The metabolism of Ixazomib can be increased when combined with Tecovirimat. |
| Teduglutide | Teduglutide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tegafur | Tegafur may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Telaprevir | The metabolism of Ixazomib can be decreased when combined with Telaprevir. |
| Telavancin | Telavancin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Telithromycin | The metabolism of Ixazomib can be decreased when combined with Telithromycin. |
| Telotristat ethyl | The serum concentration of Ixazomib can be decreased when it is combined with Telotristat ethyl. |
| Temazepam | Temazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Temozolomide | Temozolomide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Teniposide | The metabolism of Ixazomib can be decreased when combined with Teniposide. |
| Tenofovir alafe | The serum concentration of Tenofovir alafenamide can be increased when it is combined with Ixazomib. |
| Tenofovir diso | Tenofovir disoproxil may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Terbinafine | The metabolism of Ixazomib can be increased when combined with Terbinafine. |
| Terbutaline | Terbutaline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Terfenadine | The metabolism of Ixazomib can be decreased when combined with Terfenadine. |
| Testolactone | Testolactone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Testosterone | The metabolism of Ixazomib can be increased when combined with Testosterone. |
| Testosterone | Ixazomib may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level. |
| Testosterone ena | Ixazomib may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level. |
| Testosterone prop | Testosterone propionate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Testosterone unde | Ixazomib may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level. |
| Tetracaine | The risk or severity of methemoglobinemia can be increased when Ixazomib is combined with Tetracaine. |
| Tetracycline | The metabolism of Ixazomib can be decreased when combined with Tetracycline. |
| Tetradecyl hydrog | Ixazomib may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. |
| Thiabendazole | Thiabendazole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Thiamylal | The metabolism of Ixazomib can be increased when combined with Thiamylal. |
| Thiethylperazine | Thiethylperazine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Ticagrelor | The metabolism of Ixazomib can be decreased when combined with Ticagrelor. |
| Ticlopidine | Ticlopidine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tiludronic acid | Tiludronic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Timolol | Timolol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tinidazole | Tinidazole may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tiopronin | Tiopronin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tiotropium | Tiotropium may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tipranavir | The metabolism of Ixazomib can be decreased when combined with Tipranavir. |
| Tirofiban | Tirofiban may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tixocortol | Tixocortol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tobramycin | Ixazomib may decrease the excretion rate of Tobramycin which could result in a higher serum level. |
| Tocilizumab | The metabolism of Ixazomib can be increased when combined with Tocilizumab. |
| Tocopherol | Ixazomib may decrease the excretion rate of Tocopherol which could result in a higher serum level. |
| Tolazamide | Tolazamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tolbutamide | Tolbutamide may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tolcapone | Tolcapone may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tolfenamic acid | Tolfenamic acid may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tolterodine | Tolterodine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tolvaptan | Tolvaptan may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Topiramate | The metabolism of Ixazomib can be increased when combined with Topiramate. |
| Topotecan | Topotecan may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Torasemide | Torasemide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Tositumomab | Tositumomab may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Tramadol | Tramadol may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Trametinib | Trametinib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Triamcinolone | The metabolism of Ixazomib can be increased when combined with Triamcinolone. |
| Triamterene | Triamterene may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Triazolam | Triazolam may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Trichlormethiazide | Trichlormethiazide may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy. |
| Triclabendazole | The metabolism of Ixazomib can be decreased when combined with Triclabendazole. |
| Triethylenetetramine | Triethylenetetramine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Trifluridine | Trifluridine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Trimebutine | Trimebutine may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Trimethoprim | Trimethoprim may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Trimetrexate | Trimetrexate may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Troglitazone | The metabolism of Ixazomib can be increased when combined with Troglitazone. |
| Troleandomycin | The metabolism of Ixazomib can be decreased when combined with Troleandomycin. |
| Tropisetron | Ixazomib may decrease the excretion rate of Tropisetron which could result in a higher serum level. |
| Tucatinib | The metabolism of Tucatinib can be decreased when combined with Ixazomib. |
| Vaborbactam | Ixazomib may decrease the excretion rate of Vaborbactam which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Valbenazine | Ixazomib may decrease the excretion rate of Valbenazine which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Valganciclovir | Valganciclovir may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Valproic acid | The metabolism of Ixazomib can be decreased when combined with Valproic acid. |
| Vancomycin | Ixazomib may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
| Varenicline | Varenicline may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
| Vemurafenib | The metabolism of Ixazomib can be increased when combined with Vemurafenib. |
| Venetoclax | The metabolism of Ixazomib can be decreased when combined with Venetoclax. |
Pregnancy and Lactation
AU TGA pregnancy category: C
US FDA pregnancy category: Not assigned.
Pregnancy
This drug can cause fetal harm when administered to a pregnant woman. Females of reproductive potential should be advised to avoid becoming pregnant while being treated with this drug. Male and female patients of reproductive potential should use effective contraceptive measures during and for 90 days following therapy with this drug. Females using oral hormonal contraceptives should additionally use a barrier method of contraception. Based on animals and the drug mechanism of action, this drug can cause fetal harm.
Lactation
No information is available on the clinical use of ixazomib during breastfeeding. Because its half-life is about 9.5 days, it is likely to accumulate in the infant. It is also given in combination with leflunomide and dexamethasone, which may increase the risk to the infant. The manufacturer recommends that breastfeeding be discontinued during ixazomib therapy and for 90 days after the last dose.
Why is this medication prescribed?
Ixazomib is used in combination with lenalidomide (Revlimid) and dexamethasone to treat multiple myeloma (cancer of the plasma cells in the bone marrow) that has worsened after treatment with other chemotherapy medications. Ixazomib is in a class of medications called proteasome inhibitors. It works by helping to kill cancer cells.
How should this medicine be used?
Ixazomib comes as a capsule to take by mouth. It is usually taken with water on an empty stomach, at least 1 hour before or 2 hours after eating. It is taken on days 1,8, and 15 of a 28 day treatment cycle. Take ixazomib at around the same time on every day that you take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ixazomib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not take ixazomib and dexamethasone at the same time because you should take dexamethasone with food.
Swallow the capsules whole; do not split, chew, or crush them.
Be careful when handling ixazomib capsules. Do not allow your skin, eyes, mouth, or nose to come into contact with broken or crushed ixazomib capsules. If such contact occurs, wash your skin well with soap and water or rinse your eyes well with plain water.
If you vomit after taking ixazomib, do not repeat the dose. Take your next dose of ixazomib on the next scheduled day that you are supposed to take it.
Your doctor may need to temporarily or permanently stop your treatment or decrease your dose of ixazomib, or of the other medications that you are taking, depending on the side effects that you experience. Be sure to talk to your doctor about how you are feeling during your treatment. Do not stop taking ixazomib without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking ixazomib,
- tell your doctor and pharmacist if you are allergic to ixazomib, any other medications, or any of the ingredients in ixazomib capsules. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Epitol, Equetro, Carbatrol, Tegretol, Teril), efavirenz (Sustiva, in Atripla), nevirapine (Viramune), phenobarbital, pioglitazone (Actos, in Actoplus, Duetact, Oseni), phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), and rifampin (Rifadin, Rimactane, in Rifamate, Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John’s wort.
- tell your doctor if you have or have ever had liver or kidney disease.
- tell your doctor if you are pregnant or plan to become pregnant, or plan to father a child. You should not become pregnant while you are taking ixazomib. Use effective birth control during your treatment with ixazomib and for 90 days after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for 90 days after your final dose. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while taking ixazomib, call your doctor immediately. Ixazomib can harm the fetus.
- tell your doctor if you are breastfeeding. You should not breastfeed while you are taking ixazomib.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is within 72 hours (3 days) of your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
References
