Ifosfamide – Uses, Dosage, Side Effects, Interaction Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma, and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric, and lung cancer. Ifosfamide therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute liver injury, including acute cholestatic hepatitis and venous-occlusive disease. Ifosfamide is a chemotherapeutic agent chemically related to nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04) Ifosfamide is the simplest member of the class of ifosfamide’s that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer. It has a role as an antineoplastic agent, an immunosuppressive agent, an alkylating agent, an environmental contaminant, and a xenobiotic. Mechanism of Action The exact mechanism of ifosfamide has not been determined but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of ifosfamide alkylate bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily through the alkylation of DNA, done by attaching the N-7 position of guanine to its reactive electrophilic groups. The formation of inter and intra-strand cross-links in the DNA results in cell death. Mechanism of action: metabolites cause the alkylation of DNA. Ifosfamide, a structural analog of cyclophosphamide, belongs to the oxazaphosphorine class of antitumor alkylating agents which must be activated by the mixed-function oxidase system of the liver. The 4-hydroxy oxazaphosphorines are a reactive species capable of interacting with nucleic acids & cellular materials to cause cell damage & death. The 4-hydroxy metabolite spontaneously liberates acrolein in many sites throughout the body & it is this substance that is responsible for oxazaphosphorine urotoxicity. Both ifosfamide & cyclophosphamide produce cystitis characterized by tissue edema & ulceration followed by sloughing of mucosal epithelial cells, necrosis of smooth muscle fibers & arteries, & culminating in focal hemorrhage. The selective urotoxicity of oxazaphosphorine occurs because the bladder contains a very low content of thiol cmpds (glutathione, cysteine) which, by virtue of their nucleophilic sulfhydryl groups, are able to react & neutralize many reactive chemicals. Because the metabolic activation of ifosfamide proceeds more slowly than that of cyclophosphamide, doses of ifosfamide are 3-4 times higher than those of cyclophosphamide. This explains the higher incidence of urotoxicity associated with ifosfamide. Ifosfamide requires activation by microsomal liver enzymes to active metabolites in order to exert its cytotoxic effects. Activation occurs by hydroxylation at the ring carbon atom 4 to form the unstable intermediate 4-hydroxyifosfamide. This metabolite then rapidly degrades to the stable urinary metabolite 4-ketoifosfamide. The stable urinary metabolite, 4-carboxyifosfamide, is formed upon the opening of the ring. These urinary metabolites have not been found to be cytotoxic. N, N-bis (2-chloroethyl)-phosphoric acid diamide (phosphoramide) and acrolein are also found. The major urinary metabolites, dechloroethyl ifosfamide, and dechloroethyl cyclophosphamide are formed upon enzymatic oxidation of the chloroethyl side chains and subsequent dealkylation. It is the alkylated metabolites of ifosfamide that have been shown to interact with DNA. Ifosfamide is cycle-phase nonspecific. Indications Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin’s lymphoma. Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Ifosfamide is an alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteosarcoma, bladder cancer, small cell lung cancer, and non-Hodgkin’s lymphoma. Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin’s lymphoma. Bladder Cancer, Cancer Cervical Cancer Ewing’s Sarcoma Head and Neck Carcinoma Lymphoma, Hodgkins Malignant Neoplasm of Pancreas Non-Hodgkin’s Lymphoma (NHL) Osteosarcoma Ovarian Cancer Small Cell Lung Cancer (SCLC) Soft Tissue Sarcoma Testicular Germ Cell Cancer Advanced thymic carcinoma Use in Cancer.gov Ifosfamide is approved to be used with other drugs to treat: Testicular germ cell tumors that are malignant. It is used in patients who have already been treated with two other types of chemotherapy. Ifosfamide is also being studied in the treatment of other types of cancer. Therapeutic Uses Ifosfamide currently is approved for use in combination with other drugs for germ-cell testicular cancer & is widely used to treat pediatric & adult sarcomas. Clinical trials also have shown ifosfamide to be active against carcinomas of the cervix & lung & against lymphomas. It is a common component of high-dose chemotherapy regimens with bone marrow or stem cell rescue; in these regimens, in total doses of 12-14 g/sq m, it may cause severe neurological toxicity, including coma & death. This toxicity is thought to result from a metabolite, chloracetaldehyde. In addition to hemorrhagic cystitis, ifosfamide causes nausea, vomiting, anorexia, leukopenia, nephrotoxicity, & CNS disturbances (especially somnolence & confusion). Ifosfamide is indicated, in combination with other antineoplastic agents and a prophylactic agent against hemorrhagic cystitis (such as mesna), for the treatment of germ cell testicular tumors. Ifosfamide is indicated as reasonable medical therapy for the treatment of head and neck carcinoma. Ifosfamide is used for the treatment of soft-tissue sarcomas, Ewing’s sarcoma, and Hodgkin’s and non-Hodgkin’s lymphomas. Ifosfamide is indicated for the treatment of breast carcinomas, cervical carcinoma, small cell lung carcinoma, non-small cell lung carcinoma, ovarian epithelial carcinoma, acute lymphocytic leukemia, neuroblastoma, and osteosarcoma. Ifosfamide, in combination therapy, is considered reasonable medical therapy at some point in the management of germ-cell ovarian tumors. (Evidence rating: IIID). Ifosfamide, alone and in combination with other chemotherapeutic agents, is considered reasonable medical therapy at some point in the management of bladder carcinoma (Evidence rating: IIID) and endometrial carcinoma (Evidence rating IIIA). Ifosfamide is indicated, alone or in combination with other chemotherapeutic agents, as second-line therapy for the treatment of Wilms’ tumor in patients who have not responded to or whose disease has progressed during previous treatment (Evidence rating: IIID). FDA Approved Indications Ifosfamide is an alkylating agent and an analog of cyclophosphamide, used as a single agent or in combination with other agents to treat a wide variety of malignancies. These malignancies include[rx]: Germline tumor of the testis Soft tissue sarcomas Ewing sarcoma Cervical cancer, either recurrent or metastatic Advanced bladder carcinoma Non-Hodgkin lymphoma Hodgkin lymphoma Small and nonsmall cell lung carcinoma Osteosarcoma Ovarian cancer Thymic cancer Among all these cancers, the Food and Drug Administration (FDA) has approved the drug only for germline tumors of the testis. The indications for the use of ifosfamide include: Germline Tumor of the Testis – The FDA-approved regimen is ifosfamide and mesna at a 1.2 g/m²/day dose for five days, repeated every three weeks or following count recovery. When using ifosfamide and other chemotherapeutic drugs, mainly cisplatin, paclitaxel, or etoposide, there has been complete remission in about 21 to 26% of the treated population. Aggressive hydration (at least 2 liters oral or IV) is necessary during administration. Soft Tissue Sarcomas (off-label use) – Noncomparative studies have shown that combination therapy with ifosfamide/mesna has demonstrated objective response rates of around 40% when used as induction therapy.[rx] Ewing Sarcoma (off-label use) – Doses of ifosfamide vary based on the age group. Used alongside vincristine, etoposide, doxorubicin along with mesna in different regimens. Overall, survival is better with combination therapies. [rx] Cervical Cancer, Recurrent, or Metastatic (off-label use) – Ifosfamide is dosed along with mesna at 1500 g/m2/day every three weeks. When used along with paclitaxel and cisplatin, the response rate was 18 to 45%.[rx] Bladder Carcinoma: Mainly Advanced Carcinoma (off-label use) [rx] Non-Hodgkin Lymphoma (off-label use) – Used in Burkitt lymphoma and diffuse large B cell lymphoma (DLBCL) as salvage therapy. Hodgkin Lymphoma (off-label use) [rx] – Used in relapsed or refractory cases in the RICE regimen (rituximab, ifosfamide, carboplatin, and etoposide) along with mesna. Small and Non-small-cell cancer[rx]: When used as maintenance or consolidation has been shown to have more benefits than standard regimens. Osteosarcoma (off-label use) Ovarian Cancer – Used in advanced stages that are platinum-resistant. Many additional trials are underway. Response rates have been more than 40% when used as a combination. Thymic Cancer – Used in advanced stages of thymic cancer. [12] Contraindications There are very few known contraindications for the use of ifosfamide. The absolute contraindications are known hypersensitivity to the drug or its components and urinary tract outflow obstruction. Relative contraindications include myelosuppression and severe renal or hepatic impairment. Known hypersensitivity to the drug and/or its components – can result in anaphylaxis with drug administration.[rx] Urinary outflow obstruction – there is a high chance of developing cystitis when there is urinary tract obstruction due to an accumulation of toxic compounds.[rx] Severe thrombocytopenia and leukopenia – due to the known toxic effect of hematologically, the drug is avoided in severe thrombocytopenia and leukopenia. Severe renal or hepatic impairment – drug metabolism occurs in the liver, and the drug is excreted by the kidneys, prohibiting its use in severe renal and hepatic impairment.[rx] cancer metastasis to bone dehydration low amount of potassium in the blood Fanconi syndrome is a condition of the kidneys resulting in excessive urination, thirst, and vomiting anemia decreased blood platelets low levels of white blood cells confusion generalized disorder of peripheral nerves liver problems renal tubular acidosis decreased kidney function inflammation and bleeding of the bladder due to chemotherapy coma the high amount of bilirubin in the blood abnormal liver function tests impaired wound healing pregnancy a patient who is producing milk and breastfeeding the operation to remove kidney tissue Dosage Strengths: 1 g; 3 g; 50 mg/mL Testicular Cancer 1.2 g/m2 IV over at least 30 minutes daily for 5 consecutive days; repeat every 3 weeks or after recovery from hematologic toxicity To prevent bladder toxicity, this drug should be given with extensive hydration (at least 2 liters of oral or IV fluid daily). Mesna should be used to reduce hemorrhagic cystitis. For germ-cell testicular cancer, the dosing regimen is 1.2 g/m²/day IV for the initial five days of a 21-day cycle. IV infusion is typically for a period of 30 minutes along with IV hydration and mesna to prevent bladder toxicity. Ifosfamide is emetogenic; hence, antiemetics are routinely prescribed to prevent chemotherapy-induced nausea and vomiting. Precipitation of ifosfamide-induced encephalopathy (IIE) by aprepitant has been reported in the literature. [rx][rx] Side Effects The Most Common nausea vomiting loss of appetite diarrhea sores in the mouth and throat hair loss the general feeling of pain and tiredness swelling, redness, and pain in the place where the medication was injected rash fever, chills, flu symptoms; mouth and throat ulcers; skin sores, pale skin, cold hands, and feet; easy bruising, unusual bleeding rapid heart rate, shallow breathing; or little or no urination, painful or difficult urination, blood in your urine; loss of bladder control; feeling light-headed or short of breath. confusion, unusual thoughts or behavior, hallucinations, seizure (convulsions); itching difficulty breathing or swallowing shortness of breath wheezing irregular heartbeat chest pain hoarseness yellowing of the skin or eyes More common Agitation black, tarry stools blood in the urine chest pain confusion cough or hoarseness fever or chills Diarrhea hair loss or thinning of the hair swelling or inflammation of the mouth Redness, swelling, or pain at place of injection weight loss frequent urination hallucinations (seeing, hearing, or feeling things that are not there) lower back or side pain painful or difficult urination pale skin shortness of breath sore throat sores, ulcers, or white spots on the lips or in the mouth swollen glands troubled breathing with exertion unusual bleeding or bruising unusual tiredness or weakness Rare Abdominal or stomach pain or tenderness bleeding gums bluish color changes in skin color clay colored stools dark urine decreased appetite dizziness headache itching loss of appetite nausea and vomiting pain pinpoint red spots on the skin skin rash swelling of the feet or lower legs yellow eyes or skin Blurred vision burning, numbness, tingling, or painful sensations confusion convulsions (seizures) dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position fast or irregular heartbeat sweating troubled breathing unsteadiness or awkwardness weakness in the arms, hands, legs, or feet Drug Interactions Abacavir Abacavir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Abametapir The serum concentration of Ifosfamide can be increased when it is combined with Abametapir. Abatacept The metabolism of Ifosfamide can be increased when combined with Abatacept. Abciximab The risk or severity of bleeding can be increased when Ifosfamide is combined with Abciximab. Abemaciclib The metabolism of Abemaciclib can be increased when combined with Ifosfamide. Abiraterone The metabolism of Ifosfamide can be decreased when combined with Abiraterone. Abrocitinib The metabolism of Abrocitinib can be decreased when combined with Ifosfamide. Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Ifosfamide. Aceclofenac Aceclofenac may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Acenocoumarol The risk or severity of bleeding can be increased when Ifosfamide is combined with Acenocoumarol. Acetaminophen The metabolism of Ifosfamide can be increased when combined with Acetaminophen. Acetazolamide The metabolism of Ifosfamide can be decreased when combined with Acetazolamide. Acetohexamide The metabolism of Ifosfamide can be decreased when combined with Acetohexamide. Acetyl sulfisoxazole The metabolism of Ifosfamide can be decreased when combined with Acetyl sulfisoxazole. Acetyldigitoxin Acetyldigitoxin may decrease the cardiotoxic activities of Ifosfamide. Acetylsalicylic acid The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Ifosfamide. Aclidinium Ifosfamide may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Ifosfamide may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Adalimumab The metabolism of Ifosfamide can be increased when combined with Adalimumab. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Adenovirus type The risk or severity of infection can be increased when Adenovirus type 7 vaccine live is combined with Ifosfamide. Agomelatine The metabolism of Ifosfamide can be decreased when combined with Agomelatine. Albendazole The metabolism of Ifosfamide can be decreased when combined with Albendazole. Albutrepenonacog Ifosfamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level. Alclofenac Alclofenac may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Aldesleukin The metabolism of Ifosfamide can be decreased when combined with Aldesleukin. Alectinib The metabolism of Alectinib can be increased when combined with Ifosfamide. Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Ifosfamide. Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Ifosfamide. Alfentanil The metabolism of Ifosfamide can be decreased when combined with Alfentanil. Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Ifosfamide. Allogeneic The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Ifosfamide. Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Ifosfamide. Almasilate Ifosfamide may decrease the excretion rate of Almasilate which could result in a higher serum level. Almotriptan The metabolism of Almotriptan can be increased when combined with Ifosfamide. Alogliptin Ifosfamide may decrease the excretion rate of Alogliptin which could result in a higher serum level. Alosetron The metabolism of Ifosfamide can be decreased when combined with Alosetron. Alpelisib The metabolism of Ifosfamide can be increased when combined with Alpelisib. Alprazolam The metabolism of Alprazolam can be decreased when combined with Ifosfamide. Alteplase The risk or severity of bleeding can be increased when Ifosfamide is combined with Alteplase. Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Ifosfamide. Amantadine Amantadine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ambrisentan The metabolism of Ifosfamide can be decreased when combined with Ambrisentan. Amikacin Ifosfamide may decrease the excretion rate of Amikacin which could result in a higher serum level. Amiloride Amiloride may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Aminoglutethimide The metabolism of Ifosfamide can be increased when combined with Aminoglutethimide. Aminophenazone The metabolism of Aminophenazone can be increased when combined with Ifosfamide. Aminophylline The metabolism of Aminophylline can be increased when combined with Ifosfamide. Aminosalicylic acid The risk or severity of methemoglobinemia can be increased when Aminosalicylic acid is combined with Ifosfamide. Amiodarone The metabolism of Ifosfamide can be decreased when combined with Amiodarone. Amitriptyline The metabolism of Ifosfamide can be decreased when combined with Amitriptyline. Amlodipine The metabolism of Amlodipine can be increased when combined with Ifosfamide. Ammonium chloride Ifosfamide may decrease the excretion rate of Ammonium chloride which could result in a higher serum level. Amobarbital The metabolism of Ifosfamide can be increased when combined with Amobarbital. Amodiaquine The metabolism of Amodiaquine can be increased when combined with Ifosfamide. Amoxicillin Amoxicillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Amphetamine Amphetamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Amphotericin B Amphotericin B may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ampicillin Ampicillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Amprenavir The metabolism of Ifosfamide can be increased when combined with Amprenavir. Amrinone Ifosfamide may decrease the excretion rate of Amrinone which could result in a higher serum level. Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Ifosfamide. Amyl Nitrite The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Amyl Nitrite. Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Ifosfamide. Anakinra The metabolism of Ifosfamide can be increased when combined with Anakinra. Anastrozole The risk or severity of cardiotoxicity can be increased when Ifosfamide is combined with Anastrozole. Ancestim Ifosfamide may decrease the excretion rate of Ancestim which could result in a higher serum level. Ancrod The risk or severity of bleeding can be increased when Ifosfamide is combined with Ancrod. Anifrolumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Anifrolumab. Anistreplase The risk or severity of bleeding can be increased when Ifosfamide is combined with Anistreplase. Anthrax immune The therapeutic efficacy of Anthrax immune globulin human can be decreased when used in combination with Ifosfamide. Anthrax vaccine The risk or severity of infection can be increased when Anthrax vaccine is combined with Ifosfamide. Antihemophilic Ifosfamide may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level. Antilymphocyte The risk or severity of adverse effects can be increased when Ifosfamide is combined with Antilymphocyte immunoglobulin (horse). Antipyrine The metabolism of Ifosfamide can be decreased when combined with Antipyrine. Antithrombin Alfa The risk or severity of bleeding can be increased when Ifosfamide is combined with Antithrombin Alfa. Antithrombin III The risk or severity of bleeding can be increased when Ifosfamide is combined with Antithrombin III human. Antithymocyte The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Ifosfamide. Antrafenine Antrafenine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Apalutamide The metabolism of Ifosfamide can be increased when combined with Apalutamide. Apixaban The risk or severity of bleeding can be increased when Ifosfamide is combined with Apixaban. Apomorphine The metabolism of Ifosfamide can be decreased when combined with Apomorphine. Apremilast The metabolism of Ifosfamide can be increased when combined with Apremilast. Aprepitant The metabolism of Ifosfamide can be decreased when combined with Aprepitant. Ardeparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Ardeparin. Arformoterol The metabolism of Arformoterol can be decreased when combined with Ifosfamide. Argatroban The risk or severity of bleeding can be increased when Ifosfamide is combined with Argatroban. Aripiprazole The metabolism of Aripiprazole can be increased when combined with Ifosfamide. Aripiprazole The metabolism of Aripiprazole lauroxil can be increased when combined with Ifosfamide. Armodafinil The metabolism of Ifosfamide can be increased when combined with Armodafinil. Arsenic trioxide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Ifosfamide. Artemether The metabolism of Ifosfamide can be increased when combined with Artemether. Articaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Articaine. Asciminib The serum concentration of Ifosfamide can be increased when it is combined with Asciminib. Astemizole The metabolism of Astemizole can be increased when combined with Ifosfamide. COVID-19 Vaccine The therapeutic efficacy of AstraZeneca COVID-19 Vaccine can be decreased when used in combination with Ifosfamide. Asunaprevir The metabolism of Ifosfamide can be increased when combined with Asunaprevir. Atazanavir The metabolism of Ifosfamide can be decreased when combined with Atazanavir Atomoxetine Atomoxetine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Ifosfamide. Atovaquone The metabolism of Ifosfamide can be decreased when combined with Atovaquone. Auranofin Auranofin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Aurothioglucose Ifosfamide may decrease the excretion rate of Aurothioglucose which could result in a higher serum level. Avacopan The metabolism of Ifosfamide can be decreased when combined with Avacopan. Avanafil The serum concentration of Avanafil can be increased when it is combined with Ifosfamide. Avapritinib The metabolism of Ifosfamide can be decreased when combined with Avapritinib. Avatrombopag The metabolism of Ifosfamide can be increased when combined with Avatrombopag. Axitinib The metabolism of Axitinib can be increased when combined with Ifosfamide. Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Ifosfamide. Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Ifosfamide. Azelaic acid Azelaic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Azelastine The metabolism of Ifosfamide can be decreased when combined with Azelastine. Azithromycin The metabolism of Ifosfamide can be decreased when combined with Azithromycin. Aztreonam Aztreonam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Bacillus The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Ifosfamide. Bacillusantigen The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Ifosfamide. Bacillus calmette The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Ifosfamide. Bacitracin Bacitracin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Baclofen Baclofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Balsalazide Balsalazide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Baricitinib The risk or severity of adverse effects can be increased when Ifosfamide is combined with Baricitinib. Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Ifosfamide. BCG vaccine The risk or severity of infection can be increased when BCG vaccine is combined with Ifosfamide. Beclomethasone The metabolism of Ifosfamide can be increased when combined with Beclomethasone dipropionate. Belatacept The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belatacept. Belimumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belimumab. Belinostat The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belinostat. Belumosudil The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belumosudil. Belzutifan The serum concentration of Ifosfamide can be decreased when it is combined with Belzutifan. Bemiparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Bemiparin. Bendamustine The risk or severity of adverse effects can be increased when Ifosfamide is combined with Bendamustine. Bendroflumethiazide Bendroflumethiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Benorilate Benorilate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Benoxaprofen Benoxaprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Benserazide Ifosfamide may decrease the excretion rate of Benserazide which could result in a higher serum level. Benzatropine Benzatropine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Benznidazole Ifosfamide may decrease the excretion rate of Benznidazole which could result in a higher serum level. Benzocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Benzocaine. Benzphetamine The metabolism of Ifosfamide can be decreased when combined with Benzphetamine. Benzthiazide Benzthiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Benzydamine Benzydamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Benzyl alcohol. Bepotastine Ifosfamide may decrease the excretion rate of Bepotastine which could result in a higher serum level. Berotralstat The serum concentration of Ifosfamide can be increased when it is combined with Berotralstat. Betamethasone The metabolism of Ifosfamide can be increased when combined with Betamethasone. Betamethasone The metabolism of Ifosfamide can be increased when combined with Betamethasone phosphate. Betrixaban The risk or severity of bleeding can be increased when Ifosfamide is combined with Betrixaban. Bevacizumab The risk or severity of cardiotoxicity can be increased when Bevacizumab is combined with Ifosfamide. Bexarotene The metabolism of Ifosfamide can be increased when combined with Bexarotene. Bezafibrate The metabolism of Ifosfamide can be decreased when combined with Bezafibrate. Bicalutamide The metabolism of Bicalutamide can be increased when combined with Ifosfamide. Bicisate Ifosfamide may decrease the excretion rate of Bicisate which could result in a higher serum level. Bifonazole The metabolism of Ifosfamide can be decreased when combined with Bifonazole. Bimekizumab The metabolism of Ifosfamide can be increased when combined with Bimekizumab. Bismuth Ifosfamide may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level. Bisoprolol Bisoprolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Bisoxatin Ifosfamide may decrease the excretion rate of Bisoxatin which could result in a higher serum level. Bivalirudin The risk or severity of bleeding can be increased when Ifosfamide is combined with Bivalirudin. Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Ifosfamide. Blinatumomab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Blinatumomab. Boceprevir The metabolism of Ifosfamide can be decreased when combined with Boceprevir. Bordetella The therapeutic efficacy of Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) can be decreased when used in combination with Ifosfamide. Bortezomib The metabolism of Bortezomib can be increased when combined with Ifosfamide. Bosentan The metabolism of Ifosfamide can be increased when combined with Bosentan. Bosutinib The metabolism of Bosutinib can be increased when combined with Ifosfamide. Brentuximab vedotin The metabolism of Brentuximab vedotin can be increased when combined with Ifosfamide. Brigatinib The metabolism of Ifosfamide can be increased when combined with Brigatinib. Brivaracetam The metabolism of Ifosfamide can be decreased when combined with Brivaracetam. Brodalumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Brodalumab. Bromazepam Ifosfamide may decrease the excretion rate of Bromazepam which could result in a higher serum level. Bromotheophylline Bromotheophylline may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Brompheniramine The metabolism of Ifosfamide can be decreased when combined with Brompheniramine. Budesonide The metabolism of Ifosfamide can be increased when combined with Budesonide. Bumadizone Bumadizone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Bumetanide Bumetanide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Bupivacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Bupivacaine. Buprenorphine The metabolism of Ifosfamide can be decreased when combined with Buprenorphine. Bupropion The metabolism of Ifosfamide can be decreased when combined with Bupropion. Buspirone The metabolism of Ifosfamide can be decreased when combined with Buspirone. Busulfan The risk or severity of hemorrhagic cystitis can be increased when Busulfan is combined with Ifosfamide. Butabarbital Butabarbital may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Butacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Butacaine. Butalbital The metabolism of Ifosfamide can be increased when combined with Butalbital. Butamben The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Butamben. Cabazitaxel The metabolism of Cabazitaxel can be increased when combined with Ifosfamide. Cabergoline The metabolism of Cabergoline can be increased when combined with Ifosfamide. Cabozantinib The metabolism of Ifosfamide can be decreased when combined with Cabozantinib. Calcitriol The metabolism of Ifosfamide can be increased when combined with Calcitriol. Canagliflozin Canagliflozin may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Canakinumab The metabolism of Ifosfamide can be increased when combined with Canakinumab. Candesartan The metabolism of Ifosfamide can be decreased when combined with Candesartan cilexetil. Candicidin The metabolism of Ifosfamide can be decreased when combined with Candicidin. Cangrelor The risk or severity of bleeding can be increased when Ifosfamide is combined with Cangrelor. Cannabidiol The metabolism of Ifosfamide can be decreased when combined with Cannabidiol. Canrenoic acid Canrenoic acid may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Ifosfamide. Caplacizumab The risk or severity of bleeding can be increased when Caplacizumab is combined with Ifosfamide. Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Ifosfamide. Capreomycin Ifosfamide may decrease the excretion rate of Capreomycin which could result in a higher serum level. Capsaicin The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Capsaicin. Carbamazepine The metabolism of Ifosfamide can be increased when combined with Carbamazepine. Carbidopa Carbidopa may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Ifosfamide. Carfilzomib The risk or severity of adverse effects can be increased when Ifosfamide is combined with Carfilzomib. Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Ifosfamide. Carprofen Carprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Carvedilol The metabolism of Ifosfamide can be decreased when combined with Carvedilol. Cefaclor Cefaclor may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefadroxil Cefadroxil may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefalotin Cefalotin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefamandole Cefamandole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefapirin Cefapirin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefazolin Cefazolin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefdinir Cefdinir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefditoren Cefditoren may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefepime Cefepime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefmenoxime Cefmenoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefmetazole Cefmetazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefonicid Cefonicid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefoperazone Cefoperazone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceforanide Ceforanide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefotaxime Cefotaxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefotetan Cefotetan may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefotiam Cefotiam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefoxitin Cefoxitin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefpiramide Cefpiramide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefpirome Cefpirome may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefpodoxime Cefpodoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefprozil Cefprozil may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefradine The metabolism of Ifosfamide can be increased when combined with Cefradine. Ceftaroline Ceftaroline fosamil may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceftazidime Ceftazidime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceftibuten Ceftibuten may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceftizoxime Ceftizoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceftobiprole Ceftobiprole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceftolozane Ifosfamide may decrease the excretion rate of Ceftolozane which could result in a higher serum level. Ceftriaxone Ceftriaxone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cefuroxime Cefuroxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Celecoxib The risk or severity of methemoglobinemia can be increased when Celecoxib is combined with Ifosfamide. Cenobamate The metabolism of Ifosfamide can be increased when combined with Cenobamate. Cephalexin The metabolism of Ifosfamide can be decreased when combined with Cephalexin. Cephaloglycin Cephaloglycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ceritinib The metabolism of Ceritinib can be increased when combined with Ifosfamide. Cerivastatin The metabolism of Ifosfamide can be increased when combined with Cerivastatin. Certolizumab The metabolism of Ifosfamide can be increased when combined with Certolizumab pegol. Cetirizine Cetirizine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cevimeline Cevimeline may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Chloral hydrate Ifosfamide may decrease the excretion rate of Chloral hydrate which could result in a higher serum level. Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Ifosfamide. Chloramphenicol The metabolism of Ifosfamide can be decreased when combined with Chloramphenicol. Chloroprocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Chloroprocaine. Chloroquine The metabolism of Ifosfamide can be decreased when combined with Chloroquine. Chlorothiazide Chlorothiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Chloroxylenol Ifosfamide may decrease the excretion rate of Chloroxylenol which could result in a higher serum level. Chlorpheniramine The metabolism of Ifosfamide can be decreased when combined with Chlorpheniramine. Chlorpromazine The metabolism of Ifosfamide can be increased when combined with Chlorpromazine. Chlorpropamide Chlorpropamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Chlorthalidone Chlorthalidone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Chlorzoxazone The metabolism of Ifosfamide can be decreased when combined with Chlorzoxazone. Choline C 11 Ifosfamide may decrease the excretion rate of Choline C 11 which could result in a higher serum level. Choline magnesi Choline magnesium trisalicylate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Choline salicylate Ifosfamide may decrease the excretion rate of Choline salicylate which could result in a higher serum level. Chondroitin sulfate Ifosfamide may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Chromic chloride Ifosfamide may decrease the excretion rate of Chromic chloride which could result in a higher serum level. Chromic nitrate Ifosfamide may decrease the excretion rate of Chromic nitrate which could result in a higher serum level. Chromium Ifosfamide may decrease the excretion rate of Chromium which could result in a higher serum level. Chromium gluconate Ifosfamide may decrease the excretion rate of Chromium gluconate which could result in a higher serum level. Chromium nicotinate Ifosfamide may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level. Chromous sulfate Ifosfamide may decrease the excretion rate of Chromous sulfate which could result in a higher serum level. Ciclesonide The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ciclesonide. Cidofovir Cidofovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Cilostazol The metabolism of Cilostazol can be decreased when combined with Ifosfamide. Cimetidine The metabolism of Ifosfamide can be decreased when combined with Cimetidine. Cinchocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Cinchocaine. Cinnarizine The metabolism of Ifosfamide can be decreased when combined with Cinnarizine. Ciprofloxacin The metabolism of Ifosfamide can be decreased when combined with Ciprofloxacin. Cisapride The metabolism of Ifosfamide can be decreased when combined with Cisapride. Cisplatin The metabolism of Ifosfamide can be decreased when combined with Cisplatin. Citalopram The metabolism of Ifosfamide can be decreased when combined with Citalopram. Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Ifosfamide. Clarithromycin The metabolism of Ifosfamide can be decreased when combined with Clarithromycin. Clevidipine The metabolism of Ifosfamide can be increased when combined with Clevidipine. Clindamycin The metabolism of Clindamycin can be increased when combined with Ifosfamide. Clobazam The metabolism of Ifosfamide can be increased when combined with Clobazam. Clobetasol The metabolism of Ifosfamide can be increased when combined with Clobetasol propionate. Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Ifosfamide. Clofazimine The metabolism of Ifosfamide can be decreased when combined with Clofazimine. Clofibrate The metabolism of Ifosfamide can be increased when combined with Clofibrate. Clomipramine The metabolism of Clomipramine can be increased when combined with Ifosfamide. Clonazepam The metabolism of Clonazepam can be increased when combined with Ifosfamide. Clonidine The metabolism of Clonidine can be increased when combined with Ifosfamide. Clopidogrel The metabolism of Ifosfamide can be decreased when combined with Clopidogrel. Clorazepic acid Clorazepic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Clostridium The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Ifosfamide. Clotiazepam The metabolism of Ifosfamide can be decreased when combined with Clotiazepam. Clove oil Ifosfamide may decrease the excretion rate of Clove oil which could result in a higher serum level. Clozapine The metabolism of Ifosfamide can be increased when combined with Clozapine. Cobicistat The metabolism of Ifosfamide can be decreased when combined with Cobicistat. You Might Also Read Avanafil Indications Contraindications, Warning Cobimetinib The metabolism of Cobimetinib can be increased when combined with Ifosfamide. Cocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Cocaine. Colchicine The metabolism of Colchicine can be decreased when combined with Ifosfamide. Colistimethate Colistimethate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Colistin Ifosfamide may decrease the excretion rate of Colistin which could result in a higher serum level. Conivaptan The metabolism of Ifosfamide can be decreased when combined with Conivaptan. Conjugated Conjugated estrogens may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Copanlisib The metabolism of Copanlisib can be increased when combined with Ifosfamide. Corifollitropin alfa Ifosfamide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. Corticotropin The metabolism of Ifosfamide can be increased when combined with Corticotropin. Cortisone acetate The metabolism of Ifosfamide can be increased when combined with Cortisone acetate. Corynebacterium The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Ifosfamide. Crizotinib The metabolism of Ifosfamide can be decreased when combined with Crizotinib. Curcumin The metabolism of Ifosfamide can be decreased when combined with Curcumin. Cyanocobalamin The therapeutic efficacy of Cyanocobalamin can be decreased when used in combination with Ifosfamide. Cyclizine The metabolism of Ifosfamide can be decreased when combined with Cyclizine. Cyclopenthiazide Cyclopenthiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Cyclophosphamide The metabolism of Ifosfamide can be increased when combined with Cyclophosphamide. Cyclosporine Ifosfamide may increase the immunosuppressive activities of Cyclosporine. Cyclothiazide Cyclothiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Cyproterone The metabolism of Ifosfamide can be decreased when combined with Cyproterone acetate. Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Ifosfamide. Dabigatran The risk or severity of bleeding can be increased when Ifosfamide is combined with Dabigatran. Dabigatran The risk or severity of bleeding can be increased when Ifosfamide is combined with Dabigatran etexilate. Dabrafenib The metabolism of Ifosfamide can be increased when combined with Dabrafenib. Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Ifosfamide. Daclatasvir The metabolism of Ifosfamide can be decreased when combined with Daclatasvir. Dacomitinib The metabolism of Dacomitinib can be increased when combined with Ifosfamide. Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Ifosfamide. Dalfampridine Ifosfamide may decrease the excretion rate of Dalfampridine which could result in a higher serum level. Dalfopristin The metabolism of Ifosfamide can be decreased when combined with Dalfopristin. Dalteparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Dalteparin. Danaparoid The risk or severity of bleeding can be increased when Ifosfamide is combined with Danaparoid. Danazol The metabolism of Ifosfamide can be decreased when combined with Danazol. Dapagliflozin Dapagliflozin may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Dapsone The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Ifosfamide. Daptomycin Daptomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Darbepoetin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Ifosfamide. Darunavir The serum concentration of Ifosfamide can be increased when it is combined with Darunavir. Dasabuvir The metabolism of Dasabuvir can be increased when combined with Ifosfamide. Dasatinib The metabolism of Dasatinib can be increased when combined with Ifosfamide. Daunorubicin The metabolism of Ifosfamide can be decreased when combined with Daunorubicin. Decitabine The risk or severity of adverse effects can be increased when Ifosfamide is combined with Decitabine. Deferasirox The metabolism of Ifosfamide can be increased when combined with Deferasirox. Deferiprone Ifosfamide may decrease the excretion rate of Deferiprone which could result in a higher serum level. Defibrotide The risk or severity of bleeding can be increased when Ifosfamide is combined with Defibrotide. Deflazacort The metabolism of Ifosfamide can be increased when combined with Deflazacort. Delafloxacin The metabolism of Ifosfamide can be increased when combined with Delafloxacin. Delavirdine The metabolism of Ifosfamide can be decreased when combined with Delavirdine. Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Ifosfamide. Desipramine The metabolism of Ifosfamide can be decreased when combined with Desipramine. Desirudin The risk or severity of bleeding can be increased when Ifosfamide is combined with Desirudin. Deslanoside Deslanoside may decrease the cardiotoxic activities of Ifosfamide. Desmopressin Desmopressin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Desogestrel The metabolism of Desogestrel can be increased when combined with Ifosfamide. Desoximetasone The risk or severity of adverse effects can be increased when Desoximetasone is combined with Ifosfamide. Desvenlafaxine The metabolism of Ifosfamide can be decreased when combined with Desvenlafaxine. Deucravacitinib The risk or severity of adverse effects can be increased when Ifosfamide is combined with Deucravacitinib. Deutetrabenazine The metabolism of Ifosfamide can be decreased when combined with Deutetrabenazine. Dexamethasone The metabolism of Ifosfamide can be increased when combined with Dexamethasone. Dexamethasone The metabolism of Ifosfamide can be increased when combined with Dexamethasone acetate. Dexibuprofen The metabolism of Dexibuprofen can be increased when combined with Ifosfamide. Dexketoprofen Dexketoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Dexmedetomidine Dexmedetomidine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Dexpanthenol Ifosfamide may decrease the excretion rate of Dexpanthenol which could result in a higher serum level. Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Ifosfamide. Dextran The risk or severity of bleeding can be increased when Ifosfamide is combined with Dextran. Dextromethorphan The metabolism of Ifosfamide can be decreased when combined with Dextromethorphan. Dextropropoxyphene The metabolism of Ifosfamide can be decreased when combined with Dextropropoxyphene. Diacerein The metabolism of Ifosfamide can be decreased when combined with Diacerein. Diatrizoate Diatrizoate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Diazepam The metabolism of Ifosfamide can be decreased when combined with Diazepam. Dichlorobenzyl Ifosfamide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level. Diclofenac The metabolism of Ifosfamide can be decreased when combined with Diclofenac. Diclofenamide Diclofenamide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Dicloxacillin The metabolism of Ifosfamide can be increased when combined with Dicloxacillin. Dicoumarol The risk or severity of bleeding can be increased when Ifosfamide is combined with Dicoumarol. Dicyclomine Dicyclomine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Didanosine Didanosine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Dienogest The metabolism of Dienogest can be increased when combined with Ifosfamide. Diethylstilbestrol The metabolism of Ifosfamide can be decreased when combined with Diethylstilbestrol. Diflunisal Diflunisal may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Difluocortolone The metabolism of Ifosfamide can be increased when combined with Difluocortolone. Digitoxin The metabolism of Digitoxin can be increased when combined with Ifosfamide. Digoxin Ifosfamide may decrease the excretion rate of Digoxin which could result in a higher serum level. Dihydroergocornine The metabolism of Ifosfamide can be decreased when combined with Dihydroergocornine. Dihydroergocristine The metabolism of Ifosfamide can be decreased when combined with Dihydroergocristine. Dihydroergotamine The metabolism of Dihydroergotamine can be increased when combined with Ifosfamide. Dihydrostreptomycin Dihydrostreptomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Diltiazem The metabolism of Ifosfamide can be decreased when combined with Diltiazem. Dimercaprol Ifosfamide may decrease the excretion rate of Dimercaprol which could result in a higher serum level. Dimethyl fumarate The risk or severity of adverse effects can be increased when Ifosfamide is combined with Dimethyl fumarate. Dimethyl sulfoxide The metabolism of Ifosfamide can be decreased when combined with Dimethyl sulfoxide. Dinutuximab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Dinutuximab. Diosmin The metabolism of Ifosfamide can be decreased when combined with Diosmin. Diphenhydramine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Diphenhydramine. Dipyridamole The risk or severity of bleeding can be increased when Ifosfamide is combined with Dipyridamole. Diroximel fumarate The risk or severity of adverse effects can be increased when Ifosfamide is combined with Diroximel fumarate. Disopyramide Disopyramide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Disulfiram The metabolism of Ifosfamide can be decreased when combined with Disulfiram Dobutamine Dobutamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Docetaxel The metabolism of Docetaxel can be increased when combined with Ifosfamide. Doconexent The metabolism of Ifosfamide can be decreased when combined with Doconexent. Dofetilide The metabolism of Dofetilide can be increased when combined with Ifosfamide. Domperidone The metabolism of Ifosfamide can be decreased when combined with Domperidone. Donepezil The metabolism of Ifosfamide can be decreased when combined with Donepezil. Dopamine Dopamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Doravirine The metabolism of Ifosfamide can be decreased when combined with Doravirine. Doripenem Ifosfamide may decrease the excretion rate of Doripenem which could result in a higher serum level. Dosulepin The metabolism of Dosulepin can be decreased when combined with Ifosfamide. Doxacurium Doxacurium may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Doxazosin The metabolism of Ifosfamide can be decreased when combined with Doxazosin. Doxepin Doxepin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Doxorubicin The metabolism of Doxorubicin can be increased when combined with Ifosfamide. Doxycycline Doxycycline may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Ifosfamide. Dronedarone The serum concentration of Ifosfamide can be increased when it is combined with Dronedarone. Drospirenone The metabolism of Ifosfamide can be decreased when combined with Drospirenone. Drotrecogin alfa The risk or severity of bleeding can be increased when Ifosfamide is combined with Drotrecogin alfa. Droxidopa Ifosfamide may decrease the excretion rate of Droxidopa which could result in a higher serum level. Duloxetine Duloxetine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Dutasteride The metabolism of Ifosfamide can be decreased when combined with Dutasteride. Duvelisib The metabolism of Ifosfamide can be decreased when combined with Duvelisib. Dyclonine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Dyclonine. Dyphylline Dyphylline may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ebastine The metabolism of Ifosfamide can be decreased when combined with Ebastine. Ebola Zaire The therapeutic efficacy of Ebola Zaire vaccine (live, attenuated) can be decreased when used in combination with Ifosfamide. Echinacea The metabolism of Ifosfamide can be increased when combined with Echinacea. Eculizumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Eculizumab. Edetic acid The risk or severity of bleeding can be increased when Ifosfamide is combined with Edetic acid. Edoxaban The risk or severity of bleeding can be increased when Ifosfamide is combined with Edoxaban. Edrophonium Edrophonium may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Ifosfamide. Efavirenz The metabolism of Ifosfamide can be increased when combined with Efavirenz. Elagolix The metabolism of Elagolix can be increased when combined with Ifosfamide. Elbasvir The metabolism of Ifosfamide can be decreased when combined with Elbasvir. Eletriptan The metabolism of Ifosfamide can be increased when combined with Eletriptan. Elexacaftor The metabolism of Ifosfamide can be decreased when combined with Elexacaftor. Eliglustat The metabolism of Eliglustat can be decreased when combined with Ifosfamide. Eltrombopag The metabolism of Ifosfamide can be decreased when combined with Eltrombopag. Elvitegravir The metabolism of Ifosfamide can be decreased when combined with Elvitegravir. Emapalumab The metabolism of Ifosfamide can be increased when combined with Emapalumab. Enalaprilat Ifosfamide may decrease the excretion rate of Enalaprilat which could result in a higher serum level. Enasidenib The metabolism of Ifosfamide can be increased when combined with Enasidenib. Enoxaparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Enoxaparin. Entrectinib The metabolism of Entrectinib can be increased when combined with Ifosfamide. Enzalutamide The metabolism of Ifosfamide can be increased when combined with Enzalutamide. Epinastine The metabolism of Ifosfamide can be decreased when combined with Epinastine. Epinephrine The metabolism of Ifosfamide can be decreased when combined with Epinephrine. Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Ifosfamide. Eplerenone The metabolism of Ifosfamide can be decreased when combined with Eplerenone. Epoprostenol The risk or severity of bleeding can be increased when Ifosfamide is combined with Epoprostenol. Eptifibatide The risk or severity of bleeding can be increased when Eptifibatide is combined with Ifosfamide. Erdafitinib The metabolism of Erdafitinib can be increased when combined with Ifosfamide. Ergotamine The metabolism of Ifosfamide can be decreased when combined with Ergotamine. Eribulin The risk or severity of adverse effects can be increased when Ifosfamide is combined with Eribulin. Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Ifosfamide. Ertapenem Ertapenem may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ertugliflozin Ertugliflozin may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Erythromycin The metabolism of Ifosfamide can be decreased when combined with Erythromycin. Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Ifosfamide. Esketamine The metabolism of Ifosfamide can be increased when combined with Esketamine. Eslicarbazepine The metabolism of Ifosfamide can be increased when combined with Eslicarbazepine. Eslicarbazepine acetate The metabolism of Ifosfamide can be increased when combined with Eslicarbazepine acetate. Estazolam Ifosfamide may decrease the excretion rate of Estazolam which could result in a higher serum level. Estetrol The metabolism of Ifosfamide can be decreased when combined with Estetrol. Estradiol The metabolism of Ifosfamide can be decreased when combined with Estradiol. Estradiol acetate The metabolism of Ifosfamide can be increased when combined with Estradiol acetate. Estradiol benzoate The metabolism of Ifosfamide can be increased when combined with Estradiol benzoate. Estradiol cypionate The metabolism of Ifosfamide can be increased when combined with Estradiol cypionate. Estradiol dienanthate The metabolism of Ifosfamide can be increased when combined with Estradiol dienanthate. Estradiol valerate The metabolism of Ifosfamide can be increased when combined with Estradiol valerate. Estramustine The risk or severity of adverse effects can be increased when Ifosfamide is combined with Estramustine. Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Ifosfamide. Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Ifosfamide. Etacrynic acid Etacrynic acid may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Etafedrine Ifosfamide may decrease the excretion rate of Etafedrine which could result in a higher serum level. Etanercept The metabolism of Ifosfamide can be increased when combined with Etanercept. Ethambutol The metabolism of Ifosfamide can be decreased when combined with Ethambutol. Ethanol The metabolism of Ifosfamide can be increased when combined with Ethanol. Ethinylestradiol The metabolism of Ifosfamide can be decreased when combined with Ethinylestradiol. Ethotoin The metabolism of Ifosfamide can be increased when combined with Ethotoin. Ethyl chloride The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Ethyl chloride. Ethynodiol diacetate The metabolism of Ethynodiol diacetate can be increased when combined with Ifosfamide. Etidocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Etidocaine. Etodolac Etodolac may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Etomidate Etomidate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Etonogestrel The metabolism of Etonogestrel can be increased when combined with Ifosfamide. Etoposide The metabolism of Ifosfamide can be increased when combined with Etoposide. Etoricoxib The metabolism of Ifosfamide can be decreased when combined with Etoricoxib. Etravirine The metabolism of Ifosfamide can be increased when combined with Etravirine. Eucalyptus oil Ifosfamide may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level. Everolimus The metabolism of Everolimus can be increased when combined with Ifosfamide. Ezogabine Ifosfamide may decrease the excretion rate of Ezogabine which could result in a higher serum level. Famtozinameran The therapeutic efficacy of Famtozinameran can be decreased when used in combination with Ifosfamide. Favipiravir The metabolism of Ifosfamide can be decreased when combined with Favipiravir. Felbamate The metabolism of Ifosfamide can be increased when combined with Felbamate. Felodipine The metabolism of Ifosfamide can be decreased when combined with Felodipine. Fenbufen Fenbufen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fenfluramine The metabolism of Ifosfamide can be decreased when combined with Fenfluramine. Fenofibrate The metabolism of Ifosfamide can be decreased when combined with Fenofibrate. Fenofibric acid Ifosfamide may decrease the excretion rate of Fenofibric acid which could result in a higher serum level. Fenoldopam Fenoldopam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fenoprofen Fenoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fentanyl The metabolism of Fentanyl can be decreased when combined with Ifosfamide. Fesoterodine Ifosfamide may decrease the excretion rate of Fesoterodine which could result in a higher serum level. Fexinidazole The metabolism of Ifosfamide can be decreased when combined with Fexinidazole. Filgotinib The risk or severity of adverse effects can be increased when Ifosfamide is combined with Filgotinib. Finasteride The metabolism of Ifosfamide can be decreased when combined with Finasteride. Finerenone The serum concentration of Finerenone can be increased when it is combined with Ifosfamide. Fingolimod Ifosfamide may increase the immunosuppressive activities of Fingolimod. Flavoxate Flavoxate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Flecainide The metabolism of Ifosfamide can be decreased when combined with Flecainide. Floctafenine Floctafenine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Florbetaben (18F) Ifosfamide may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level. Florbetapir (18F) Ifosfamide may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level. Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Ifosfamide. Flucloxacillin The metabolism of Ifosfamide can be increased when combined with Flucloxacillin. Fluconazole The metabolism of Ifosfamide can be decreased when combined with Fluconazole. Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Ifosfamide. Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Ifosfamide. Fludeoxyglucose Ifosfamide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level. Fludrocortisone The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Ifosfamide. Fluindione The risk or severity of bleeding can be increased when Ifosfamide is combined with Fluindione. Flumazenil Ifosfamide may decrease the excretion rate of Flumazenil which could result in a higher serum level. Flunarizine The metabolism of Flunarizine can be decreased when combined with Ifosfamide. Flunisolide The metabolism of Ifosfamide can be increased when combined with Flunisolide. Flunitrazepam The metabolism of Ifosfamide can be decreased when combined with Flunitrazepam. Fluocinolone The metabolism of Ifosfamide can be increased when combined with Fluocinolone acetonide. Fluocinonide The metabolism of Ifosfamide can be increased when combined with Fluocinonide. Fluocortolone The metabolism of Ifosfamide can be increased when combined with Fluocortolone. Fluorometholone The risk or severity of adverse effects can be increased when Fluorometholone is combined with Ifosfamide. Fluorouracil The metabolism of Fluorouracil can be increased when combined with Ifosfamide. Fluoxetine The metabolism of Ifosfamide can be decreased when combined with Fluoxetine. Flupentixol The risk or severity of myelosuppression can be increased when Flupentixol is combined with Ifosfamide. Fluprednisolone The risk or severity of adverse effects can be increased when Ifosfamide is combined with Fluprednisolone. Flurazepam The metabolism of Ifosfamide can be decreased when combined with Flurazepam. Flurbiprofen Flurbiprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Flutamide The metabolism of Ifosfamide can be decreased when combined with Flutamide. Fluticasone The metabolism of Ifosfamide can be increased when combined with Fluticasone. Fluticasone furoate The metabolism of Ifosfamide can be increased when combined with Fluticasone furoate. Fluticasone The metabolism of Ifosfamide can be decreased when combined with Fluticasone propionate. Fluvastatin The metabolism of Ifosfamide can be decreased when combined with Fluvastatin. Fluvoxamine The metabolism of Ifosfamide can be decreased when combined with Fluvoxamine. Folic acid Folic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fomepizole The metabolism of Ifosfamide can be decreased when combined with Fomepizole. Fondaparinux The risk or severity of bleeding can be increased when Ifosfamide is combined with Fondaparinux. Formestane The metabolism of Ifosfamide can be increased when combined with Formestane. Formoterol The metabolism of Ifosfamide can be decreased when combined with Formoterol. Fosamprenavir The metabolism of Ifosfamide can be decreased when combined with Fosamprenavir. Fosaprepitant The metabolism of Ifosfamide can be increased when combined with Fosaprepitant. Foscarnet Foscarnet may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fosfomycin Fosfomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fosinopril Fosinopril may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Fosnetupitant The metabolism of Ifosfamide can be decreased when combined with Fosnetupitant. Fosphenytoin The metabolism of Ifosfamide can be increased when combined with Fosphenytoin. Fostamatinib The metabolism of Ifosfamide can be decreased when combined with Fostamatinib. Framycetin Framycetin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Furosemide Furosemide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Fusidic acid The metabolism of Ifosfamide can be decreased when combined with Fusidic acid. Gabapentin Ifosfamide may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level. Gadobenic acid Gadobenic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Gadodiamide Gadodiamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Gadofosveset Ifosfamide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level. Gadopentetic acid Gadopentetic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Gadoteric acid Ifosfamide may decrease the excretion rate of Gadoteric acid which could result in a higher serum level. Gadoteridol Gadoteridol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Gallium nitrate The risk or severity of adverse effects can be increased when Ifosfamide is combined with Gallium nitrate. Ganciclovir Ganciclovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Gefitinib The metabolism of Ifosfamide can be decreased when combined with Gefitinib. Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Ifosfamide. Gemfibrozil The metabolism of Ifosfamide can be decreased when combined with Gemfibrozil. Gemtuzumab The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Ifosfamide. Gentamicin Ifosfamide may decrease the excretion rate of Gentamicin which could result in a higher serum level. Gestrinone The metabolism of Gestrinone can be increased when combined with Ifosfamide. Gilteritinib The metabolism of Ifosfamide can be decreased when combined with Gilteritinib. Gimeracil Ifosfamide may decrease the excretion rate of Gimeracil which could result in a higher serum level. Ginkgo biloba The metabolism of Ifosfamide can be decreased when combined with Ginkgo biloba. Givosiran Givosiran may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Glasdegib The metabolism of Glasdegib can be increased when combined with Ifosfamide. Glatiramer The risk or severity of adverse effects can be increased when Ifosfamide is combined with Glatiramer. Glecaprevir The metabolism of Ifosfamide can be decreased when combined with Glecaprevir. Gliclazide The metabolism of Ifosfamide can be decreased when combined with Gliclazide. Glimepiride The metabolism of Ifosfamide can be decreased when combined with Glimepiride. Glipizide Glipizide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Gliquidone The metabolism of Gliquidone can be decreased when combined with Ifosfamide. Glyburide The metabolism of Ifosfamide can be decreased when combined with Glyburide. Glycerol The metabolism of Ifosfamide can be increased when combined with Glycerol phenylbutyrate. Golimumab The metabolism of Ifosfamide can be increased when combined with Golimumab. Golodirsen Ifosfamide may decrease the excretion rate of Golodirsen which could result in a higher serum level. Goserelin Goserelin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Griseofulvin The metabolism of Ifosfamide can be increased when combined with Griseofulvin. Guanethidine Guanethidine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Guanfacine Guanfacine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Guselkumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Guselkumab. Haemophilus The therapeutic efficacy of Haemophilus influenzae type B strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen can be decreased when used in combination with Ifosfamide. Halofantrine The metabolism of Ifosfamide can be decreased when combined with Halofantrine. Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Ifosfamide. Halothane The metabolism of Ifosfamide can be decreased when combined with Halothane. You Might Also Read Glucarpidase - Uses, Dosage, Side Effects, Interaction Ketamine The metabolism of Ifosfamide can be increased when combined with Ketamine. Ketazolam The metabolism of Ifosfamide can be decreased when combined with Ketazolam. Ketoconazole The metabolism of Ifosfamide can be decreased when combined with Ketoconazole. Ketoprofen Ketoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ketorolac The metabolism of Ketorolac can be increased when combined with Ifosfamide. Labetalol Labetalol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lacosamide The metabolism of Ifosfamide can be decreased when combined with Lacosamide. Lamivudine Lamivudine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lamotrigine Lamotrigine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lanreotide The metabolism of Ifosfamide can be decreased when combined with Lanreotide. Lansoprazole The metabolism of Ifosfamide can be increased when combined with Lansoprazole. Lapatinib The metabolism of Ifosfamide can be decreased when combined with Lapatinib. Latamoxef Latamoxef may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ledipasvir Ifosfamide may decrease the excretion rate of Ledipasvir which could result in a higher serum level. Lefamulin The serum concentration of Ifosfamide can be increased when it is combined with Lefamulin. Leflunomide The risk or severity of adverse effects can be increased when Ifosfamide is combined with Leflunomide. Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Ifosfamide. Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Ifosfamide. Lepirudin The risk or severity of bleeding can be increased when Ifosfamide is combined with Lepirudin. Lercanidipine The metabolism of Ifosfamide can be decreased when combined with Lercanidipine. Lesinurad The metabolism of Ifosfamide can be increased when combined with Lesinurad. Letermovir The metabolism of Ifosfamide can be decreased when combined with Letermovir. Letrozole The metabolism of Ifosfamide can be decreased when combined with Letrozole. Leuprolide Leuprolide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Levacetylmethadol The metabolism of Levacetylmethadol can be increased when combined with Ifosfamide. Levamlodipine The serum concentration of Levamlodipine can be increased when it is combined with Ifosfamide. Levobupivacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Levobupivacaine. Levocarnitine Levocarnitine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Levocetirizine Ifosfamide may decrease the excretion rate of Levocetirizine which could result in a higher serum level. Levofloxacin Levofloxacin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Levoketoconazole The metabolism of Ifosfamide can be decreased when combined with Levoketoconazole. Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Ifosfamide. Levonorgestrel The metabolism of Ifosfamide can be decreased when combined with Levonorgestrel. Levosalbutamol Ifosfamide may decrease the excretion rate of Levosalbutamol which could result in a higher serum level. Levothyroxine The metabolism of Ifosfamide can be decreased when combined with Levothyroxine. Lidocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Lidocaine. Linagliptin The metabolism of Ifosfamide can be decreased when combined with Linagliptin. Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Ifosfamide. Linzagolix The serum concentration of Ifosfamide can be increased when it is combined with Linzagolix. Liothyronine Liothyronine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Liotrix The metabolism of Ifosfamide can be decreased when combined with Liotrix. Lipegfilgrastim Ifosfamide may increase the myelosuppressive activities of Lipegfilgrastim. Lisinopril Lisinopril may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lithium carbonate Ifosfamide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level. Lithium citrate Lithium citrate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lixisenatide Ifosfamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level. Lofexidine Ifosfamide may decrease the excretion rate of Lofexidine which could result in a higher serum level. Lomitapide The metabolism of Lomitapide can be increased when combined with Ifosfamide. Lomustine The risk or severity of adverse effects can be increased when Ifosfamide is combined with Lomustine. Lonafarnib The metabolism of Ifosfamide can be decreased when combined with Lonafarnib. Loperamide The metabolism of Loperamide can be increased when combined with Ifosfamide. Lopinavir The serum concentration of Ifosfamide can be increased when it is combined with Lopinavir. Loracarbef Loracarbef may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Loratadine The metabolism of Ifosfamide can be decreased when combined with Loratadine. Lorazepam Lorazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lorcaserin The metabolism of Ifosfamide can be decreased when combined with Lorcaserin. Lorlatinib The metabolism of Ifosfamide can be increased when combined with Lorlatinib. Lornoxicam Lornoxicam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lorpiprazole Ifosfamide may decrease the excretion rate of Lorpiprazole which could result in a higher serum level. Losartan The metabolism of Ifosfamide can be decreased when combined with Losartan. Lovastatin The metabolism of Lovastatin can be decreased when combined with Ifosfamide. Loxoprofen Loxoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lubiprostone Lubiprostone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lumacaftor The metabolism of Ifosfamide can be increased when combined with Lumacaftor. Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Ifosfamide. Lumiracoxib Lumiracoxib may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Lynestrenol The metabolism of Lynestrenol can be increased when combined with Ifosfamide. Macitentan Ifosfamide may decrease the excretion rate of Macitentan which could result in a higher serum level. Magnesium The serum concentration of Magnesium can be decreased when it is combined with Ifosfamide. Magnesium c Ifosfamide may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Magnesium chlor Ifosfamide may decrease the excretion rate of Magnesium chloride which could result in a higher serum level. Magnesium hydrox Ifosfamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. Magnesium trisil Ifosfamide may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level. Mangafodipir Ifosfamide may decrease the excretion rate of Mangafodipir which could result in a higher serum level. Manidipine The metabolism of Ifosfamide can be decreased when combined with Manidipine. Mannitol Mannitol may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Maprotiline Maprotiline may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Mavacamten The serum concentration of Ifosfamide can be decreased when it is combined with Mavacamten. Measles virus vaccine The therapeutic efficacy of Measles virus vaccine live attenuated can be decreased when used in combination with Ifosfamide. Mecamylamine Mecamylamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Ifosfamide. Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Medroxyprogesterone The metabolism of Ifosfamide can be increased when combined with Medroxyprogesterone acetate. Mefenamic acid Mefenamic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Megestrol acetate The metabolism of Megestrol acetate can be increased when combined with Ifosfamide. Meloxicam The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Meloxicam. Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Ifosfamide. Memantine The metabolism of Ifosfamide can be decreased when combined with Memantine. Meningococcal The therapeutic efficacy of Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine can be decreased when used in combination with Ifosfamide. Meperidine The metabolism of Ifosfamide can be decreased when combined with Meperidine. Mephenytoin The metabolism of Ifosfamide can be decreased when combined with Mephenytoin. Mepivacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Mepivacaine. Mepolizumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Mepolizumab. Meprednisone The metabolism of Ifosfamide can be increased when combined with Meprednisone. Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Ifosfamide. Meropenem Meropenem may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Mesalazine Mesalazine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Mestranol The metabolism of Mestranol can be increased when combined with Ifosfamide. Metamfetamine Ifosfamide may decrease the excretion rate of Metamfetamine which could result in a higher serum level. Metamizole The risk or severity of myelosuppression can be increased when Metamizole is combined with Ifosfamide. Metaxalone Metaxalone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Metformin Metformin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Methadone The metabolism of Ifosfamide can be decreased when combined with Methadone. Methazolamide Methazolamide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Methimazole The metabolism of Ifosfamide can be decreased when combined with Methimazole. Methotrexate The metabolism of Methotrexate can be increased when combined with Ifosfamide. Methoxsalen The metabolism of Ifosfamide can be decreased when combined with Methoxsalen. Methoxy The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Ifosfamide. Methoxyflurane The metabolism of Ifosfamide can be decreased when combined with Methoxyflurane. Methyldopa Methyldopa may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Methylene blue The metabolism of Ifosfamide can be decreased when combined with Methylene blue. Methylergometrine The metabolism of Ifosfamide can be decreased when combined with Methylergometrine. Methylnaltrexone Ifosfamide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. Methylphenobarbital The metabolism of Ifosfamide can be increased when combined with Methylphenobarbital. Methylprednisolone The metabolism of Ifosfamide can be increased when combined with Methylprednisolone. Methylprednisone The metabolism of Ifosfamide can be decreased when combined with Methylprednisone. Methyltestosterone The metabolism of Ifosfamide can be decreased when combined with Methyltestosterone. Methysergide The metabolism of Ifosfamide can be decreased when combined with Methysergide. Meticrane Meticrane may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Metoclopramide The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Metoclopramide. Metolazone Metolazone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Metoprolol Metoprolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Metreleptin The metabolism of Ifosfamide can be increased when combined with Metreleptin. Metronidazole The metabolism of Ifosfamide can be decreased when combined with Metronidazole. Metyrapone The metabolism of Ifosfamide can be increased when combined with Metyrapone. Mexiletine The metabolism of Ifosfamide can be decreased when combined with Mexiletine. Mianserin The metabolism of Ifosfamide can be decreased when combined with Mianserin. Miconazole The metabolism of Ifosfamide can be decreased when combined with Miconazole. Midazolam The serum concentration of Midazolam can be increased when it is combined with Ifosfamide. Midostaurin The metabolism of Ifosfamide can be increased when combined with Midostaurin. Mifepristone The serum concentration of Ifosfamide can be increased when it is combined with Mifepristone. Migalastat Ifosfamide may decrease the excretion rate of Migalastat which could result in a higher serum level. Milnacipran The metabolism of Milnacipran can be increased when combined with Ifosfamide. Milrinone Milrinone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Miocamycin The metabolism of Ifosfamide can be decreased when combined with Miocamycin. Mirabegron Ifosfamide may decrease the excretion rate of Mirabegron which could result in a higher serum level. Mirtazapine The metabolism of Ifosfamide can be decreased when combined with Mirtazapine. Mitapivat The metabolism of Ifosfamide can be increased when combined with Mitapivat. Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Ifosfamide. Mitotane The metabolism of Ifosfamide can be increased when combined with Mitotane. Mitoxantrone The risk or severity of adverse effects can be increased when Ifosfamide is combined with Mitoxantrone. Mobocertinib The serum concentration of Ifosfamide can be decreased when it is combined with Mobocertinib. Modafinil The metabolism of Ifosfamide can be increased when combined with Modafinil. MCOVID-19 Vaccine The therapeutic efficacy of Moderna COVID-19 Vaccine can be decreased when used in combination with Ifosfamide. Modified vaccinia The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Ifosfamide. Mometasone fur The metabolism of Ifosfamide can be increased when combined with Mometasone furoate. Monomethyl fuma The risk or severity of adverse effects can be increased when Ifosfamide is combined with Monomethyl fumarate. Montelukast The metabolism of Montelukast can be increased when combined with Ifosfamide. Morphine The metabolism of Morphine can be increased when combined with Ifosfamide. Mosunetuzumab The metabolism of Ifosfamide can be decreased when combined with Mosunetuzumab. Moxisylyte Ifosfamide may decrease the excretion rate of Moxisylyte which could result in a higher serum level. Mumps virus The therapeutic efficacy of Mumps virus strain B level jeryl lynn live antigen can be decreased when used in combination with Ifosfamide. Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Ifosfamide. Muzolimine Muzolimine may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Mycophenolate The metabolism of Ifosfamide can be decreased when combined with Mycophenolate mofetil. Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Ifosfamide. N-acetyltyrosine Ifosfamide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level. Nabilone The metabolism of Ifosfamide can be decreased when combined with Nabilone. Nabumetone Nabumetone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Nadolol Ifosfamide may decrease the excretion rate of Nadolol which could result in a higher serum level. Nadroparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Nadroparin. Nafcillin The metabolism of Ifosfamide can be increased when combined with Nafcillin. Naldemedine Ifosfamide may decrease the excretion rate of Naldemedine which could result in a higher serum level. Nalmefene Ifosfamide may decrease the excretion rate of Nalmefene which could result in a higher serum level. Naloxone The metabolism of Ifosfamide can be decreased when combined with Naloxone. Naproxen The metabolism of Naproxen can be increased when combined with Ifosfamide. Natalizumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Natalizumab. Nateglinide The metabolism of Ifosfamide can be decreased when combined with Nateglinide. Nedaplatin Ifosfamide may decrease the excretion rate of Nedaplatin which could result in a higher serum level. Nedocromil Nedocromil may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Nefazodone The metabolism of Ifosfamide can be decreased when combined with Nefazodone. Nelarabine The risk or severity of adverse effects can be increased when Ifosfamide is combined with Nelarabine. Nelfinavir The metabolism of Ifosfamide can be decreased when combined with Nelfinavir. Neomycin Ifosfamide may decrease the excretion rate of Neomycin which could result in a higher serum level. Neratinib The metabolism of Neratinib can be increased when combined with Ifosfamide. Netilmicin Ifosfamide may decrease the excretion rate of Netilmicin which could result in a higher serum level. Netupitant The metabolism of Ifosfamide can be decreased when combined with Netupitant. Nevirapine The metabolism of Ifosfamide can be decreased when combined with Nevirapine. Niacin The metabolism of Ifosfamide can be decreased when combined with Niacin. Nicardipine The metabolism of Ifosfamide can be decreased when combined with Nicardipine. Niclosamide The metabolism of Niclosamide can be decreased when combined with Ifosfamide. Nicorandil Ifosfamide may decrease the excretion rate of Nicorandil which could result in a higher serum level. Nicotine The metabolism of Ifosfamide can be decreased when combined with Nicotine. Nifedipine The metabolism of Ifosfamide can be increased when combined with Nifedipine. Nilotinib The metabolism of Ifosfamide can be decreased when combined with Nilotinib. Nilutamide The metabolism of Ifosfamide can be decreased when combined with Nilutamide. Nilvadipine The metabolism of Ifosfamide can be decreased when combined with Nilvadipine. Nimesulide The risk or severity of bleeding can be increased when Nimesulide is combined with Ifosfamide. Nintedanib The metabolism of Ifosfamide can be decreased when combined with Nintedanib. Nisoldipine The metabolism of Ifosfamide can be decreased when combined with Nisoldipine. Nitrendipine The metabolism of Ifosfamide can be decreased when combined with Nitrendipine. Nitric Oxide The risk or severity of methemoglobinemia can be increased when Nitric Oxide is combined with Ifosfamide. Nitrofurantoin The risk or severity of methemoglobinemia can be increased when Nitrofurantoin is combined with Ifosfamide. Nitroglycerin The risk or severity of methemoglobinemia can be increased when Nitroglycerin is combined with Ifosfamide. Nitroprusside The risk or severity of methemoglobinemia can be increased when Nitroprusside is combined with Ifosfamide. Nitrous oxide The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Nitrous oxide. Nomegestrol The metabolism of Nomegestrol can be increased when combined with Ifosfamide. Nomegestrol The metabolism of Nomegestrol acetate can be increased when combined with Ifosfamide. Norelgestromin The metabolism of Norelgestromin can be increased when combined with Ifosfamide. Norethisterone The metabolism of Ifosfamide can be decreased when combined with Norethisterone. Norethynodrel The metabolism of Norethynodrel can be increased when combined with Ifosfamide. Norgestimate The metabolism of Ifosfamide can be increased when combined with Norgestimate. Norgestrel The metabolism of Norgestrel can be increased when combined with Ifosfamide. Nortriptyline The metabolism of Nortriptyline can be increased when combined with Ifosfamide. Noscapine The metabolism of Ifosfamide can be decreased when combined with Noscapine. Nuvaxovid The therapeutic efficacy of Nuvaxovid can be decreased when used in combination with Ifosfamide. Obinutuzumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Obinutuzumab. Ocrelizumab Ocrelizumab may increase the immunosuppressive activities of Ifosfamide. Octinoxate Ifosfamide may decrease the excretion rate of Octinoxate which could result in a higher serum level. Octreotide The serum concentration of Ifosfamide can be increased when it is combined with Octreotide. Ofatumumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ofatumumab. Olanzapine The metabolism of Ifosfamide can be decreased when combined with Olanzapine. Olaparib The metabolism of Olaparib can be increased when combined with Ifosfamide. Oliceridine The serum concentration of Oliceridine can be decreased when it is combined with Ifosfamide. Olodaterol The metabolism of Olodaterol can be increased when combined with Ifosfamide. Olsalazine Olsalazine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ombitasvir The metabolism of Ombitasvir can be increased when combined with Ifosfamide. Omeprazole The metabolism of Ifosfamide can be increased when combined with Omeprazole. Ondansetron The metabolism of Ifosfamide can be decreased when combined with Ondansetron. Opium Ifosfamide may decrease the excretion rate of Opium which could result in a higher serum level. Oritavancin The metabolism of Ifosfamide can be increased when combined with Oritavancin. Orphenadrine The metabolism of Ifosfamide can be decreased when combined with Orphenadrine. Oseltamivir Oseltamivir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Osilodrostat The metabolism of Ifosfamide can be decreased when combined with Osilodrostat. Osimertinib The metabolism of Osimertinib can be increased when combined with Ifosfamide. Ospemifene The metabolism of Ifosfamide can be decreased when combined with Ospemifene. Ouabain Ouabain may decrease the cardiotoxic activities of Ifosfamide. Oxacillin Oxacillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Ifosfamide. Oxandrolone The metabolism of Ifosfamide can be decreased when combined with Oxandrolone. Oxaprozin Oxaprozin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Oxazepam Oxazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Oxcarbazepine The metabolism of Ifosfamide can be increased when combined with Oxcarbazepine. Oxetacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Oxetacaine. Oxybenzone Ifosfamide may decrease the excretion rate of Oxybenzone which could result in a higher serum level. Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Oxybuprocaine. Oxybutynin The metabolism of Ifosfamide can be decreased when combined with Oxybutynin. Oxycodone The metabolism of Ifosfamide can be decreased when combined with Oxycodone. Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Oxyquinoline Ifosfamide may decrease the excretion rate of Oxyquinoline which could result in a higher serum level. Ozanimod The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ozanimod. Paclitaxel The metabolism of Ifosfamide can be increased when combined with Paclitaxel. Pacritinib The serum concentration of Ifosfamide can be increased when it is combined with Pacritinib. Palbociclib The metabolism of Palbociclib can be increased when combined with Ifosfamide. Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Ifosfamide. Paliperidone The metabolism of Ifosfamide can be decreased when combined with Paliperidone. Palonosetron Palonosetron may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pamidronic acid Pamidronic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Panobinostat The metabolism of Panobinostat can be increased when combined with Ifosfamide. Pantoprazole Pantoprazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Paramethadione The metabolism of Paramethadione can be increased when combined with Ifosfamide. Parecoxib Parecoxib may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Paritaprevir The metabolism of Ifosfamide can be decreased when combined with Paritaprevir. Parnaparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Parnaparin. Paromomycin Paromomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Paroxetine The metabolism of Ifosfamide can be decreased when combined with Paroxetine. Pasireotide The metabolism of Ifosfamide can be decreased when combined with Pasireotide. Patent Blue Ifosfamide may decrease the excretion rate of Patent Blue which could result in a higher serum level. Pazopanib The metabolism of Pazopanib can be increased when combined with Ifosfamide. Pegaptanib Ifosfamide may decrease the excretion rate of Pegaptanib which could result in a higher serum level. Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Ifosfamide. Pegcetacoplan The risk or severity of adverse effects can be increased when Ifosfamide is combined with Pegcetacoplan. Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Ifosfamide. Peginterferon alfa The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Ifosfamide. Peginterferon alf The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Ifosfamide. Peginterferon bet The risk or severity of adverse effects can be increased when Ifosfamide is combined with Peginterferon beta-1a. Pegvisomant The metabolism of Ifosfamide can be increased when combined with Pegvisomant. Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ifosfamide. Penbutolol Ifosfamide may decrease the excretion rate of Penbutolol which could result in a higher serum level. Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Ifosfamide. Pentaerythritol Ifosfamide may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level. Pentamidine The metabolism of Ifosfamide can be decreased when combined with Pentamidine. Pentastarch Ifosfamide may decrease the excretion rate of Pentastarch which could result in a higher serum level. Pentetic acid Ifosfamide may decrease the excretion rate of Pentetic acid which could result in a higher serum level. Pentobarbital The metabolism of Ifosfamide can be increased when combined with Pentobarbital. Pentosan polysulfate The risk or severity of bleeding can be increased when Ifosfamide is combined with Pentosan polysulfate. Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Ifosfamide. Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Ifosfamide. Perampanel The metabolism of Ifosfamide can be increased when combined with Perampanel. Perhexiline The metabolism of Ifosfamide can be decreased when combined with Perhexiline. Perindopril Perindopril may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Permethrin Ifosfamide may decrease the excretion rate of Permethrin which could result in a higher serum level. Pertussis vaccine The therapeutic efficacy of Pertussis vaccine can be decreased when used in combination with Ifosfamide. Pertuzumab The risk or severity of cardiotoxicity can be increased when Ifosfamide is combined with Pertuzumab. Pexidartinib The metabolism of Pexidartinib can be increased when combined with Ifosfamide. Phenazopyridine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Phenazopyridine. Phenelzine Phenelzine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Phenindione The risk or severity of bleeding can be increased when Ifosfamide is combined with Phenindione. Phenobarbital The metabolism of Ifosfamide can be increased when combined with Phenobarbital. Phenol The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Phenol. Phenprocoumon The risk or severity of bleeding can be increased when Ifosfamide is combined with Phenprocoumon. Phentolamine Phentolamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Ifosfamide. Phenylbutazone The metabolism of Ifosfamide can be increased when combined with Phenylbutazone. Phenytoin The metabolism of Ifosfamide can be increased when combined with Phenytoin. Pholcodine Ifosfamide may decrease the excretion rate of Pholcodine which could result in a higher serum level. Phosphoric acid Ifosfamide may decrease the excretion rate of Phosphoric acid which could result in a higher serum level. Phylloquinone Phylloquinone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Picosulfuric acid Ifosfamide may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level. Pilocarpine The metabolism of Ifosfamide can be decreased when combined with Pilocarpine. Pimavanserin The metabolism of Ifosfamide can be decreased when combined with Pimavanserin. Pimecrolimus The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ifosfamide. Pimozide The metabolism of Pimozide can be increased when combined with Ifosfamide. Pindolol Pindolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pioglitazone The metabolism of Pioglitazone can be increased when combined with Ifosfamide. Piperacillin Piperacillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Piperaquine The metabolism of Ifosfamide can be decreased when combined with Piperaquine. Piracetam Ifosfamide may decrease the excretion rate of Piracetam which could result in a higher serum level. Piretanide Piretanide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Pirfenidone The risk or severity of adverse effects can be increased when Ifosfamide is combined with Pirfenidone. Piroxicam The metabolism of Piroxicam can be increased when combined with Ifosfamide. Pitavastatin The metabolism of Pitavastatin can be increased when combined with Ifosfamide. Pitolisant The metabolism of Ifosfamide can be increased when combined with Pitolisant. Plazomicin Ifosfamide may decrease the excretion rate of Plazomicin which could result in a higher serum level. Plerixafor Ifosfamide may decrease the excretion rate of Plerixafor which could result in a higher serum level. Polythiazide Polythiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Pomalidomide The metabolism of Pomalidomide can be increased when combined with Ifosfamide. Ponatinib The metabolism of Ponatinib can be increased when combined with Ifosfamide. Ponesimod The metabolism of Ifosfamide can be decreased when combined with Ponesimod. Posaconazole The metabolism of Ifosfamide can be decreased when combined with Posaconazole. Potassium Potassium may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Potassium acetate Ifosfamide may decrease the excretion rate of Potassium acetate which could result in a higher serum level. Potassium bicarb Ifosfamide may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level. Potassium cation Potassium cation may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Potassium chloride Potassium chloride may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Potassium citrate Potassium citrate may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Potassium nitrate Ifosfamide may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. Potassium perchl Ifosfamide may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level. Potassium sulfate Ifosfamide may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. Pralatrexate The risk or severity of adverse effects can be increased when Ifosfamide is combined with Pralatrexate. Pralidoxime Pralidoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pralsetinib The metabolism of Ifosfamide can be increased when combined with Pralsetinib. Pramipexole Pramipexole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pramocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Pramocaine. Prasugrel The risk or severity of bleeding can be increased when Ifosfamide is combined with Prasugrel. Praziquantel The metabolism of Ifosfamide can be decreased when combined with Praziquantel. Prednisolone The metabolism of Ifosfamide can be increased when combined with Prednisolone. Prednisolone The metabolism of Ifosfamide can be increased when combined with Prednisolone acetate. Prednisolone The metabolism of Ifosfamide can be increased when combined with Prednisolone phosphate. Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Ifosfamide. Prednisone The metabolism of Ifosfamide can be increased when combined with Prednisone acetate. Pregabalin Pregabalin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pretomanid The metabolism of Ifosfamide can be decreased when combined with Pretomanid. Prilocaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Prilocaine. Primaquine The metabolism of Ifosfamide can be decreased when combined with Primaquine. Primidone The metabolism of Ifosfamide can be increased when combined with Primidone. Probenecid The metabolism of Ifosfamide can be increased when combined with Probenecid. Procainamide Ifosfamide may decrease the excretion rate of Procainamide which could result in a higher serum level. Procaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Procaine. Procaine be Ifosfamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Ifosfamide. Progesterone The metabolism of Ifosfamide can be increased when combined with Progesterone. Proguanil The metabolism of Ifosfamide can be decreased when combined with Proguanil. Promazine The metabolism of Ifosfamide can be decreased when combined with Promazine. Promethazine The metabolism of Ifosfamide can be decreased when combined with Promethazine. Propantheline Propantheline may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Proparacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Proparacaine. Propiverine Ifosfamide may decrease the excretion rate of Propiverine which could result in a higher serum level. Propofol The metabolism of Ifosfamide can be decreased when combined with Propofol. Propoxycaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Propoxycaine. Propranolol The metabolism of Ifosfamide can be decreased when combined with Propranolol. Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Ifosfamide. Protein C The risk or severity of bleeding can be increased when Ifosfamide is combined with Protein C. Protein S human The risk or severity of bleeding can be increased when Ifosfamide is combined with Protein S human. Prucalopride The metabolism of Prucalopride can be decreased when combined with Ifosfamide. Pyrantel Ifosfamide may decrease the excretion rate of Pyrantel which could result in a higher serum level. Pyrazinamide Pyrazinamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Pyrimethamine The metabolism of Ifosfamide can be decreased when combined with Pyrimethamine. Pyrithione Ifosfamide may decrease the excretion rate of Pyrithione which could result in a higher serum level. Quazepam The metabolism of Ifosfamide can be decreased when combined with Quazepam. Quetiapine The metabolism of Ifosfamide can be decreased when combined with Quetiapine. Quinethazone Quinethazone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Quinidine The metabolism of Quinidine can be increased when combined with Ifosfamide. Quinine The metabolism of Ifosfamide can be increased when combined with Quinine. Quinupristin The metabolism of Ifosfamide can be decreased when combined with Quinupristin. Rabeprazole Rabeprazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Rabies immune The therapeutic efficacy of Rabies immune globulin, human can be decreased when used in combination with Ifosfamide. Rabies antigen, A The therapeutic efficacy of Rabies virus inactivated antigen, A can be decreased when used in combination with Ifosfamide. Rabies antigen, B The therapeutic efficacy of Rabies virus inactivated antigen, B can be decreased when used in combination with Ifosfamide. Raloxifene The metabolism of Ifosfamide can be decreased when combined with Raloxifene. Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Ifosfamide. Ramelteon Ramelteon may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ranitidine Ranitidine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ranolazine The metabolism of Ranolazine can be increased when combined with Ifosfamide. Rasagiline Ifosfamide may decrease the excretion rate of Rasagiline which could result in a higher serum level. Rasburicase The risk or severity of methemoglobinemia can be increased when Rasburicase is combined with Ifosfamide. Ravulizumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ravulizumab. Regorafenib The metabolism of Regorafenib can be increased when combined with Ifosfamide. Relugolix The metabolism of Ifosfamide can be decreased when combined with Relugolix. Remdesivir The metabolism of Ifosfamide can be decreased when combined with Remdesivir. Repaglinide The metabolism of Repaglinide can be increased when combined with Ifosfamide. Reserpine The metabolism of Ifosfamide can be increased when combined with Reserpine. Resorcinol Ifosfamide may decrease the excretion rate of Resorcinol which could result in a higher serum level. Retapamulin The metabolism of Retapamulin can be decreased when combined with Ifosfamide. Reteplase The risk or severity of bleeding can be increased when Ifosfamide is combined with Reteplase. Reviparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Reviparin. Ribavirin Ribavirin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ribociclib The metabolism of Ifosfamide can be decreased when combined with Ribociclib. Ribostamycin Ifosfamide may decrease the excretion rate of Ribostamycin which could result in a higher serum level. You Might Also Read Cefmenoxime; Indications/Uses, Dosage, Side effects, Interactions Rifabutin The metabolism of Ifosfamide can be increased when combined with Rifabutin. Rifampicin The metabolism of Ifosfamide can be increased when combined with Rifampicin. Rifamycin The metabolism of Ifosfamide can be increased when combined with Rifamycin. Rifapentine The metabolism of Ifosfamide can be increased when combined with Rifapentine. Rifaximin The metabolism of Ifosfamide can be increased when combined with Rifaximin. Rilonacept The metabolism of Ifosfamide can be increased when combined with Rilonacept. Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Ifosfamide. Rimegepant The metabolism of Rimegepant can be increased when combined with Ifosfamide. Riociguat The metabolism of Riociguat can be increased when combined with Ifosfamide. Risankizumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Risankizumab. Risperidone The metabolism of Ifosfamide can be decreased when combined with Risperidone. Ritonavir The serum concentration of Ifosfamide can be increased when it is combined with Ritonavir. Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Ifosfamide. Rivaroxaban The risk or severity of bleeding can be increased when Ifosfamide is combined with Rivaroxaban. Rizatriptan Rizatriptan may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Rofecoxib The metabolism of Ifosfamide can be increased when combined with Rofecoxib. Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Ifosfamide. Romidepsin The metabolism of Romidepsin can be increased when combined with Ifosfamide. Ropeginterfe The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ropeginterferon alfa-2b. Ropivacaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Ropivacaine. Rosiglitazone The metabolism of Rosiglitazone can be increased when combined with Ifosfamide. Rosuvastatin The metabolism of Ifosfamide can be decreased when combined with Rosuvastatin. Rotavirus vaccine The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Ifosfamide. Roxadustat The metabolism of Roxadustat can be increased when combined with Ifosfamide. Roxithromycin The metabolism of Ifosfamide can be decreased when combined with Roxithromycin. Rubella virus The risk or severity of infection can be increased when Rubella virus vaccine is combined with Ifosfamide. Rucaparib The metabolism of Ifosfamide can be decreased when combined with Rucaparib. Rufinamide The metabolism of Ifosfamide can be increased when combined with Rufinamide. Rupatadine The metabolism of Rupatadine can be decreased when combined with Ifosfamide. Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Ifosfamide. Sacubitril Ifosfamide may decrease the excretion rate of Sacubitril which could result in a higher serum level. Salbutamol Salbutamol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Salicylamide Salicylamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Salicylic acid Salicylic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Salmeterol The metabolism of Ifosfamide can be decreased when combined with Salmeterol. Salmon calcitonin Salmon calcitonin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Salsalate Salsalate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Saquinavir The metabolism of Ifosfamide can be decreased when combined with Saquinavir. Sarilumab The metabolism of Ifosfamide can be increased when combined with Sarilumab. Satralizumab The serum concentration of Ifosfamide can be decreased when it is combined with Satralizumab. Saxagliptin The metabolism of Ifosfamide can be decreased when combined with Saxagliptin. Secobarbital The metabolism of Ifosfamide can be increased when combined with Secobarbital. Secukinumab The metabolism of Ifosfamide can be increased when combined with Secukinumab. Segesterone The metabolism of Segesterone acetate can be increased when combined with Ifosfamide. Selegiline The metabolism of Ifosfamide can be decreased when combined with Selegiline. Selenious acid Ifosfamide may decrease the excretion rate of Selenious acid which could result in a higher serum level. Selenium Ifosfamide may decrease the excretion rate of Selenium which could result in a higher serum level. Selexipag The metabolism of Selexipag can be increased when combined with Ifosfamide. Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Ifosfamide. Selumetinib The metabolism of Ifosfamide can be decreased when combined with Selumetinib. Sertraline The metabolism of Ifosfamide can be decreased when combined with Sertraline. Sevoflurane The metabolism of Ifosfamide can be decreased when combined with Sevoflurane. Sibutramine Sibutramine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Sildenafil The metabolism of Ifosfamide can be decreased when combined with Sildenafil. Siltuximab The metabolism of Ifosfamide can be increased when combined with Siltuximab. Simeprevir The metabolism of Ifosfamide can be decreased when combined with Simeprevir. Simvastatin The metabolism of Ifosfamide can be decreased when combined with Simvastatin. Siponimod The metabolism of Siponimod can be increased when combined with Ifosfamide. Sipuleucel-T The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Ifosfamide. Sirolimus The metabolism of Sirolimus can be increased when combined with Ifosfamide. Sitagliptin The metabolism of Sitagliptin can be increased when combined with Ifosfamide. Sitaxentan The metabolism of Ifosfamide can be decreased when combined with Sitaxentan. Smallpox The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Ifosfamide. Sodium acetate Ifosfamide may decrease the excretion rate of Sodium acetate which could result in a higher serum level. Sodium aurothio Ifosfamide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium citrate The risk or severity of bleeding can be increased when Ifosfamide is combined with Sodium citrate. Sodium fluoride Ifosfamide may decrease the excretion rate of Sodium fluoride which could result in a higher serum level. Sodium sulfate Ifosfamide may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Sofosbuvir Ifosfamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. Solriamfetol Ifosfamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level. Somatostatin The metabolism of Ifosfamide can be decreased when combined with Somatostatin. Somatrogon The metabolism of Ifosfamide can be increased when combined with Somatrogon. Sonidegib The metabolism of Sonidegib can be increased when combined with Ifosfamide. Sorafenib The metabolism of Sorafenib can be increased when combined with Ifosfamide. Sorbitol Ifosfamide may decrease the excretion rate of Sorbitol which could result in a higher serum level. Sotorasib The serum concentration of Ifosfamide can be decreased when it is combined with Sotorasib. Spesolimab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Spesolimab. Spironolactone The metabolism of Ifosfamide can be decreased when combined with Spironolactone. St. John’s Wort The metabolism of Ifosfamide can be increased when combined with St. John’s Wort. Stiripentol The metabolism of Ifosfamide can be decreased when combined with Stiripentol. Streptokinase The risk or severity of bleeding can be increased when Ifosfamide is combined with Streptokinase. Streptomycin Ifosfamide may decrease the excretion rate of Streptomycin which could result in a higher serum level. Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Ifosfamide. Strontium chloride Ifosfamide may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Sucralfate Sucralfate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Sulbactam Ifosfamide may decrease the excretion rate of Sulbactam which could result in a higher serum level. Sulfadiazine The risk or severity of methemoglobinemia can be increased when Sulfadiazine is combined with Ifosfamide. Sulfamethizole The metabolism of Ifosfamide can be decreased when combined with Sulfamethizole. Sulfamethoxazole The risk or severity of myelosuppression can be increased when Sulfamethoxazole is combined with Ifosfamide. Sulfaphenazole The metabolism of Ifosfamide can be decreased when combined with Sulfaphenazole. Sulfapyridine The risk or severity of methemoglobinemia can be increased when Sulfapyridine is combined with Ifosfamide. Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Ifosfamide. Sulfinpyrazone The metabolism of Ifosfamide can be increased when combined with Sulfinpyrazone. Sulfisoxazole The metabolism of Ifosfamide can be decreased when combined with Sulfisoxazole. Sulindac Sulindac may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Sulodexide The risk or severity of bleeding can be increased when Ifosfamide is combined with Sulodexide. Sumatriptan Sumatriptan may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Sunitinib The metabolism of Sunitinib can be increased when combined with Ifosfamide. Suvorexant The metabolism of Ifosfamide can be decreased when combined with Suvorexant. Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Ifosfamide. Tadalafil The metabolism of Ifosfamide can be decreased when combined with Tadalafil. Tamoxifen The metabolism of Ifosfamide can be increased when combined with Tamoxifen. Tamsulosin Tamsulosin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tasimelteon The metabolism of Ifosfamide can be decreased when combined with Tasimelteon. Tazarotene The metabolism of Tazarotene can be increased when combined with Ifosfamide. Tazemetostat The metabolism of Ifosfamide can be decreased when combined with Tazemetostat. Technetium Ifosfamide may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level. Technetium Ifosfamide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level. Technetium T Ifosfamide may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level. Technetium Tc Ifosfamide may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level. Tecovirimat The metabolism of Ifosfamide can be increased when combined with Tecovirimat. Tedizolid phos The risk or severity of myelosuppression can be increased when Ifosfamide is combined with Tedizolid phosphate. Teduglutide Ifosfamide may decrease the excretion rate of Teduglutide which could result in a higher serum level. Tegafur The metabolism of Tegafur can be decreased when combined with Ifosfamide. Tegafur-uracil The metabolism of Tegafur-uracil can be decreased when combined with Ifosfamide. Tegaserod The metabolism of Ifosfamide can be decreased when combined with Tegaserod. Telaprevir The metabolism of Ifosfamide can be decreased when combined with Telaprevir. Telavancin Ifosfamide may decrease the excretion rate of Telavancin which could result in a higher serum level. Telithromycin The metabolism of Ifosfamide can be decreased when combined with Telithromycin. Telotristat ethyl The serum concentration of Ifosfamide can be decreased when it is combined with Telotristat ethyl. Temazepam Temazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Ifosfamide. Temsirolimus The metabolism of Temsirolimus can be increased when combined with Ifosfamide. Tenecteplase The risk or severity of bleeding can be increased when Ifosfamide is combined with Tenecteplase. Teniposide The metabolism of Teniposide can be increased when combined with Ifosfamide. Tenofovir a The serum concentration of Tenofovir alafenamide can be increased when it is combined with Ifosfamide. Tenofovir dis Tenofovir disoproxil may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tenoxicam Tenoxicam may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tepotinib The metabolism of Ifosfamide can be decreased when combined with Tepotinib. Teprotumumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Teprotumumab. Terbinafine The metabolism of Ifosfamide can be increased when combined with Terbinafine. Terbutaline Terbutaline may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Terfenadine The metabolism of Ifosfamide can be decreased when combined with Terfenadine. Teriflunomide The risk or severity of adverse effects can be increased when Ifosfamide is combined with Teriflunomide. Testolactone Testolactone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Testosterone The metabolism of Ifosfamide can be increased when combined with Testosterone. Testosterone The metabolism of Ifosfamide can be increased when combined with Testosterone cypionate. Testosterone The metabolism of Ifosfamide can be increased when combined with Testosterone enanthate. Testosterone pro Ifosfamide may decrease the excretion rate of Testosterone propionate which could result in a higher serum level. Testosterone unde The metabolism of Ifosfamide can be increased when combined with Testosterone undecanoate. Tetracaine The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Tetracaine. Tetracycline The metabolism of Ifosfamide can be decreased when combined with Tetracycline. Tetradecyl Ifosfamide may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level. Tezacaftor The metabolism of Ifosfamide can be decreased when combined with Tezacaftor. Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Ifosfamide. Theophylline The metabolism of Theophylline can be increased when combined with Ifosfamide. Thiabendazole Thiabendazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Thiamylal The metabolism of Ifosfamide can be increased when combined with Thiamylal. Thiethylperazine Thiethylperazine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Thiopental The metabolism of Ifosfamide can be increased when combined with Thiopental. Thiosulfuric acid The metabolism of Ifosfamide can be increased when combined with Thiosulfuric acid. Thiotepa The metabolism of Thiotepa can be increased when combined with Ifosfamide. Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Ticagrelor The risk or severity of bleeding can be increased when Ifosfamide is combined with Ticagrelor. Tick encephalitis The therapeutic efficacy of Tick-borne encephalitis vaccine (whole virus, inactivated) can be decreased when used in combination with Ifosfamide. Ticlopidine The metabolism of Ifosfamide can be decreased when combined with Ticlopidine. Tiludronic acid Tiludronic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Timolol Timolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tinidazole Tinidazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tinzaparin The risk or severity of bleeding can be increased when Ifosfamide is combined with Tinzaparin. Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Ifosfamide. Tiopronin Ifosfamide may decrease the excretion rate of Tiopronin which could result in a higher serum level. Tiotropium Ifosfamide may decrease the excretion rate of Tiotropium which could result in a higher serum level. Tipranavir The metabolism of Ifosfamide can be decreased when combined with Tipranavir. Tirofiban The risk or severity of bleeding can be increased when Tirofiban is combined with Ifosfamide. Tivozanib The metabolism of Tivozanib can be increased when combined with Ifosfamide. Tixocortol The risk or severity of adverse effects can be increased when Ifosfamide is combined with Tixocortol. Tobramycin Ifosfamide may decrease the excretion rate of Tobramycin which could result in a higher serum level. Tocilizumab The metabolism of Ifosfamide can be increased when combined with Tocilizumab. Tocopherol Ifosfamide may decrease the excretion rate of Tocopherol which could result in a higher serum level. Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Ifosfamide. Tolazamide Tolazamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tolbutamide The metabolism of Tolbutamide can be increased when combined with Ifosfamide. Tolcapone Tolcapone may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tolfenamic acid Tolfenamic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tolmetin Tolmetin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tolterodine Tolterodine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Tolvaptan The metabolism of Tolvaptan can be increased when combined with Ifosfamide. Topiramate The metabolism of Ifosfamide can be increased when combined with Topiramate. Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Ifosfamide. Torasemide Torasemide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Ifosfamide. Trabectedin The metabolism of Trabectedin can be increased when combined with Ifosfamide. Tramadol The metabolism of Tramadol can be decreased when combined with Ifosfamide. Trametinib The metabolism of Ifosfamide can be increased when combined with Trametinib. Tranylcypromine The metabolism of Ifosfamide can be decreased when combined with Tranylcypromine. Trastuzumab Trastuzumab may increase the neutropenic activities of Ifosfamide. Trastuzumab The metabolism of Trastuzumab emtansine can be increased when combined with Ifosfamide. Trazodone The metabolism of Ifosfamide can be decreased when combined with Trazodone. Treprostinil The metabolism of Treprostinil can be increased when combined with Ifosfamide. Tretinoin The metabolism of Ifosfamide can be decreased when combined with Tretinoin. Triamcinolone The metabolism of Ifosfamide can be increased when combined with Triamcinolone. Triamterene Triamterene may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Triazolam The metabolism of Ifosfamide can be decreased when combined with Triazolam. Trichlormethiazide Trichlormethiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy. Triclabendazole The metabolism of Ifosfamide can be decreased when combined with Triclabendazole. Triethylenetetramine Ifosfamide may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level. Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Ifosfamide. Trilostane The risk or severity of adverse effects can be increased when Trilostane is combined with Ifosfamide. Trimebutine Ifosfamide may decrease the excretion rate of Trimebutine which could result in a higher serum level. Trimethadione The metabolism of Trimethadione can be increased when combined with Ifosfamide. Trimethoprim The metabolism of Ifosfamide can be decreased when combined with Trimethoprim. Trimetrexate Trimetrexate may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Trimipramine The metabolism of Ifosfamide can be decreased when combined with Trimipramine. Troglitazone The metabolism of Ifosfamide can be increased when combined with Troglitazone. Troleandomycin The metabolism of Ifosfamide can be decreased when combined with Troleandomycin. Tropisetron Ifosfamide may decrease the excretion rate of Tropisetron which could result in a higher serum level. Tucatinib The metabolism of Tucatinib can be decreased when combined with Ifosfamide. Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Ifosfamide. Typhoid Vaccine The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Ifosfamide. Typhoid Vi p The therapeutic efficacy of Typhoid Vi polysaccharide vaccine can be decreased when used in combination with Ifosfamide. Udenafil The metabolism of Ifosfamide can be decreased when combined with Udenafil. Ulipristal The metabolism of Ulipristal can be increased when combined with Ifosfamide. Upadacitinib The risk or severity of adverse effects can be increased when Ifosfamide is combined with Upadacitinib. Urokinase The risk or severity of bleeding can be increased when Ifosfamide is combined with Urokinase. Vaborbactam Ifosfamide may decrease the excretion rate of Vaborbactam which could result in a higher serum level. Valaciclovir Valaciclovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Valbenazine The metabolism of Ifosfamide can be decreased when combined with Valbenazine. Valdecoxib Valdecoxib may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Valganciclovir Ifosfamide may decrease the excretion rate of Valganciclovir which could result in a higher serum level. Valproic acid The metabolism of Ifosfamide can be decreased when combined with Valproic acid. Valsartan The metabolism of Ifosfamide can be decreased when combined with Valsartan. Vancomycin Ifosfamide may decrease the excretion rate of Vancomycin which could result in a higher serum level. Vandetanib The metabolism of Vandetanib can be increased when combined with Ifosfamide. Vardenafil The metabolism of Vardenafil can be decreased when combined with Ifosfamide. Varenicline Ifosfamide may decrease the excretion rate of Varenicline which could result in a higher serum level. Varicella zoster The risk or severity of infection can be increased when Varicella zoster vaccine (live/attenuated) is combined with Ifosfamide. Varicella zoster The therapeutic efficacy of Varicella zoster vaccine (recombinant) can be decreased when used in combination with Ifosfamide. Vasopressin Ifosfamide may increase the fluid retaining and vasopressor activities of Vasopressin. Vedolizumab The risk or severity of adverse effects can be increased when Ifosfamide is combined with Vedolizumab. Velpatasvir The metabolism of Ifosfamide can be decreased when combined with Velpatasvir. Vemurafenib The metabolism of Ifosfamide can be increased when combined with Vemurafenib. Venetoclax The metabolism of Venetoclax can be increased when combined with Ifosfamide. Venlafaxine Venlafaxine may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Verapamil The metabolism of Ifosfamide can be decreased when combined with Verapamil. Vibrio cholerae The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Ifosfamide. Vilanterol The risk or severity of adverse effects can be increased when Ifosfamide is combined with Vilanterol. Viloxazine The metabolism of Ifosfamide can be decreased when combined with Viloxazine. Vinblastine The metabolism of Ifosfamide can be increased when combined with Vinblastine. Vincristine The metabolism of Vincristine can be increased when combined with Ifosfamide. Vindesine The metabolism of Vindesine can be increased when combined with Ifosfamide. Vinflunine The metabolism of Vinflunine can be increased when combined with Ifosfamide. Vinorelbine The metabolism of Vinorelbine can be increased when combined with Ifosfamide. Vismodegib The metabolism of Vismodegib can be decreased when combined with Ifosfamide. Vitamin E The metabolism of Ifosfamide can be increased when combined with Vitamin E. Voclosporin The risk or severity of adverse effects can be increased when Ifosfamide is combined with Voclosporin. Vonoprazan The metabolism of Ifosfamide can be decreased when combined with Vonoprazan. Vorapaxar The risk or severity of bleeding can be increased when Ifosfamide is combined with Vorapaxar. Voriconazole The metabolism of Ifosfamide can be decreased when combined with Voriconazole. Vorinostat The risk or severity of adverse effects can be increased when Ifosfamide is combined with Vorinostat. Vortioxetine The metabolism of Ifosfamide can be decreased when combined with Vortioxetine. Voxelotor The serum concentration of Ifosfamide can be increased when it is combined with Voxelotor. Voxilaprevir The metabolism of Voxilaprevir can be increased when combined with Ifosfamide. Warfarin The metabolism of Ifosfamide can be increased when combined with Warfarin. Ximelagatran The risk or severity of bleeding can be increased when Ifosfamide is combined with Ximelagatran. Yellow fever The risk or severity of infection can be increased when Yellow fever vaccine is combined with Ifosfamide. Zafirlukast The metabolism of Ifosfamide can be decreased when combined with Zafirlukast. Zaleplon The metabolism of Ifosfamide can be decreased when combined with Zaleplon. Zanamivir Zanamivir may decrease the excretion rate of Ifosfamide which could result in a higher serum level. Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Ifosfamide. Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Ifosfamide. Zileuton The metabolism of Ifosfamide can be decreased when combined with Zileuton. Zimelidine The metabolism of Ifosfamide can be decreased when combined with Zimelidine. Ziprasidone The metabolism of Ifosfamide can be decreased when combined with Ziprasidone. Zolpidem The metabolism of Zolpidem can be increased when combined with Ifosfamide. Zonisamide The metabolism of Ifosfamide can be decreased when combined with Zonisamide. Zopiclone The metabolism of Zopiclone can be decreased when combined with Ifosfamide. Zuclopenthixol The metabolism of Ifosfamide can be decreased when combined with Zuclopenthixol. Pregnancy and Lactation AU TGA pregnancy category: D US FDA pregnancy category: Not assigned. Pregnancy This drug can cause fetal harm when administered to a pregnant woman. Fetal growth retardation and neonatal anemia have been reported. Adequate methods of contraception should be encouraged. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus. Women should not become pregnant during therapy. Men should not father a child during therapy and for up to 6 months after. Animal studies have revealed evidence of embryotoxicity, gene mutations, and chromosomal damage. There are no controlled data on human pregnancy. Lactation Use is contraindicated. Excreted into human milk: Yes This drug is tumorigenic and can harm a nursing infant. How should this medicine be used? Ifosfamide comes as a powder to be mixed with liquid to be injected over at least 30 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. It may be injected once a day for 5 days in a row. This treatment may be repeated every 3 weeks. The length of treatment depends on how well your body responds to treatment with ifosfamide. Your doctor may need to delay your treatment if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with ifosfamide. Ifosfamide is also sometimes used to treat bladder cancer, lung cancer, cancer of the ovaries (cancer that begins in the female reproductive organs where eggs are formed), cancer of the cervix, and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). Talk to your doctor about the risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. What special precautions should I follow? Before receiving ifosfamide, tell your doctor and pharmacist if you are allergic to ifosfamide, cyclophosphamide (Cytoxan), any other medications, or any of the ingredients in the ifosfamide injection. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins and nutritional supplements you are receiving or plan to take. Be sure to mention the medication listed in the IMPORTANT WARNING section and any of the following: aprepitant (Emend); certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); certain seizure medications such as carbamazepine (Tegretol), phenobarbital (Luminal), and phenytoin (Dilantin); medications for allergies or hay fever; medications for nausea; opioid (narcotic) medications for pain; rifampin (Rifadin, Rimactane); sedatives; sleeping pills; or sorafenib (Nexavar). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with ifosfamide, so be sure to tell your doctor about all the medications you are receiving, even those that do not appear on this list. tell your doctor what herbal products you are receiving, especially St. John’s wort. tell your doctor if you have previously received treatment with other chemotherapy medications or if you have previously received radiation therapy. Also tell your doctor if you have or have ever had heart, kidney, or liver disease. you should know that ifosfamide may slow the healing of wounds. you should know that ifosfamide may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. Ifosfamide may cause permanent infertility (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breastfeeding should tell their doctors before they begin receiving this drug. You should not become pregnant or breast-feed while you are receiving ifosfamide. Use a reliable method of birth control to prevent pregnancy while you are receiving ifosfamide and for 6 months after treatments. If you are male, you and your female partner should continue to use birth control for 6 months after you stop receiving ifosfamide injections. If you become pregnant while receiving ifosfamide, call your doctor immediately. Ifosfamide may harm the fetus. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019763s016lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019763s017lbl.pdf https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1024/ https://www.ebi.ac.uk/chembl/g/#browse/targets http://ctdbase.org/about/legal.jsp https://ctdbase.org/detail.go?type=chem&acc=D007069 https://pubchem.ncbi.nlm.nih.gov/compound/Ifosfamide https://www.bindingdb.org/rwd/bind/info.jsp https://www.bindingdb.org/rwd/bind/chemsearch/marvin/MolStructure.jsp?monomerid=189358 https://www.drugs.com/mtm/ifosfamide.html https://go.drugbank.com/drugs/DB01181 https://www.ncbi.nlm.nih.gov/books/NBK542169/ https://en.wikipedia.org/wiki/Ifosfamide https://medlineplus.gov/druginfo/meds/a695023.html https://www.mayoclinic.org/drugs-supplements/ifosfamide-intravenous-route/side-effects/drg-20064266 https://www.webmd.com/drugs/2/drug-2550/ifosfamide-mesna-intravenous/details/list-contraindications http://www.dgidb.org/downloads https://www.dgidb.org/drugs/IFOSFAM https://www.drugbank.ca/legal/terms_of_use Ifosfamide https://www.drugbank.ca/drugs/DB01181 Therapeutic Target Database (TTD) Ifosfamide http://idrblab.net/ttd/data/drug/details/D02TLO https://creativecommons.org/licenses/by-nc/4.0/ Ifosfamide https://commonchemistry.cas.org/detail?cas_rn=3778-73-2 https://www.nlm.nih.gov/copyright.html https://chem.nlm.nih.gov/chemidplus/sid/0003778732 ChemIDplus Chemical Information Classification https://chem.nlm.nih.gov/chemidplus/ https://www.cancer.gov/policies/copyright-reuse ifosfamide https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=759154 ifosfamide https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=109724 EPA DSSTox LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources Ifosfamide https://comptox.epa.gov/dashboard/DTXSID7020760 CompTox Chemicals Dashboard Chemical Lists https://comptox.epa.gov/dashboard/chemical-lists/ https://echa.europa.eu/web/guest/legal-notice Ifosfamide https://echa.europa.eu/substance-information/-/substanceinfo/100.021.126 Ifosfamide https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/44783 https://www.fda.gov/about-fda/about-website/website-policies#linking IFOSFAMIDE https://gsrs.ncats.nih.gov/ginas/app/beta/substances/UM20QQM95Y Hazardous Substances Data Bank (HSDB) IFOSFAMIDE https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7023 http://www.hmdb.ca/citing Ifosfamide http://www.hmdb.ca/metabolites/HMDB0015312 HMDB0015312_nmr_one_2369 https://hmdb.ca/metabolites/HMDB0015312#spectra CCSbase IFOSFAMIDE CCSbase Classification https://ccsbase.net/ ChEBI Ifosfamide http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5864 ChEBI Ontology http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology https://www.fda.gov/about-fda/about-website/website-policies#linking IFOSFAMIDE https://dailymed.nlm.nih.gov/dailymed/browse-drug-classes.cfm FDA Pharmacological Classification https://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm LiverTox LICENSE https://www.nlm.nih.gov/copyright.html Ifosfamide https://www.ncbi.nlm.nih.gov/books/n/livertox/Ifosfamide/ https://www.cancer.gov/policies/copyright-reuse https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C564 NCI Thesaurus Tree https://ncit.nci.nih.gov https://clinicaltrials.gov/ct2/about-site/terms-conditions#Use https://clinicaltrials.gov/ DailyMed LICENSE https://www.nlm.nih.gov/copyright.html IFOSFAMIDE https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=IFOSFAMIDE https://www.fda.gov/about-fda/about-website/website-policies#linking ifosfamide https://www.fda.gov/science-research/liver-toxicity-knowledge-base-ltkb/drug-induced-liver-injury-rank-dilirank-dataset https://creativecommons.org/licenses/by/4.0/ https://www.norman-network.com/nds/SLE/ EU Clinical Trials Register https://www.clinicaltrialsregister.eu/ https://www.fda.gov/about-fda/about-website/website-policies#linking https://www.fda.gov/drugs/drug-approvals-and-databases/approved-drug-products-therapeutic-equivalence-evaluations-orange-book https://www.fda.gov/about-fda/about-website/website-policies#linking IFOSFAMIDE https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory SpectraBase https://spectrabase.com/spectrum/Gk83nInlZ98 IFOSFAMIDE;IF https://spectrabase.com/spectrum/69aftUJTO2m ISOPHOSPHAMIDE https://spectrabase.com/spectrum/B0h8H6H2x7g IPHOSPHAMIDE https://spectrabase.com/spectrum/3rV6gXAylmu IFOSFAMIDE;IF https://spectrabase.com/spectrum/3KgN0TyR3xD NIST Mass Spectrometry Data Center LICENSE https://www.nist.gov/srd/public-law Ifosfamide http://www.nist.gov/srd/nist1a.cfm https://publications.iarc.fr/Terms-Of-Use Isophosphamide https://monographs.iarc.who.int/list-of-classifications IARC Classification https://www.iarc.fr/ MassBank Europe LICENSE https://github.com/MassBank/MassBank-web/blob/main/MassBank-Project/LICENSE.txt https://massbank.eu/MassBank/Result.jsp?inchikey=HOMGKSMUEGBAAB-UHFFFAOYSA-N https://mona.fiehnlab.ucdavis.edu/documentation/license Ifosfamide https://mona.fiehnlab.ucdavis.edu/spectra/browse?query=compound.metaData%3Dq%3D%27name%3D%3D%22InChIKey%22%20and%20value%3D%3D%22HOMGKSMUEGBAAB-UHFFFAOYSA-N%22%27 NCI Cancer Drugs LICENSE https://www.cancer.gov/policies/copyright-reuse Ifex (Ifosfamide) https://www.cancer.gov/about-cancer/treatment/drugs/ifosfamide NIPH Clinical Trials Search of Japan https://rctportal.niph.go.jp/en/ https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.html ifosfamide https://rxnav.nlm.nih.gov/id/rxnorm/5657 https://www.whocc.no/copyright_disclaimer/ https://www.whocc.no/atc/ ATC Code https://www.whocc.no/atc_ddd_index/ PubChem https://pubchem.ncbi.nlm.nih.gov Springer Nature https://pubchem.ncbi.nlm.nih.gov/substance/?source=15745&sourceid=14054574-640483507 https://pubchem.ncbi.nlm.nih.gov/substance/?source=15745&sourceid=14054574-640500896 https://creativecommons.org/licenses/by-nc-nd/4.0/ https://pubchem.ncbi.nlm.nih.gov/substance/?source=22163&sourceid=14054574-640485104 https://www.who.int/about/who-we-are/publishing-policies/copyright Ifosfamide https://list.essentialmeds.org/medicines/94 https://creativecommons.org/publicdomain/zero/1.0/ Ifosfamide https://www.wikidata.org/wiki/Q418560 Wiley https://pubchem.ncbi.nlm.nih.gov/substance/?source=wiley&sourceid=119401 https://www.nlm.nih.gov/copyright.html Ifosfamide https://www.ncbi.nlm.nih.gov/mesh/68007069 MeSH Tree http://www.nlm.nih.gov/mesh/meshhome.html Antineoplastic Agents, Alkylating https://www.ncbi.nlm.nih.gov/mesh/68018906 https://www.kegg.jp/kegg/legal.html Therapeutic category of drugs in Japan http://www.genome.jp/kegg-bin/get_htext?br08301.keg Anatomical Therapeutic Chemical (ATC) classification http://www.genome.jp/kegg-bin/get_htext?br08303.keg Drug Groups http://www.genome.jp/kegg-bin/get_htext?br08330.keg UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) GHS Classification Tree http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html EPA Substance Registry Services LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources EPA SRS List Classification https://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do PATENTSCOPE (WIPO) SID 388353803 https://pubchem.ncbi.nlm.nih.gov/substance/388353803 NCBI https://www.ncbi.nlm.nih.gov/projects/linkout References