Ifosfamide - Uses, Dosage, Side Effects, Interaction

Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma, and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric, and lung cancer. Ifosfamide therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute liver injury, including acute cholestatic hepatitis and venous-occlusive disease. Ifosfamide is a chemotherapeutic agent chemically related to nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.

Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)

Ifosfamide is the simplest member of the class of ifosfamide’s that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer. It has a role as an antineoplastic agent, an immunosuppressive agent, an alkylating agent, an environmental contaminant, and a xenobiotic.

Mechanism of Action

The exact mechanism of ifosfamide has not been determined but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of ifosfamide alkylate bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily through the alkylation of DNA, done by attaching the N-7 position of guanine to its reactive electrophilic groups. The formation of inter and intra-strand cross-links in the DNA results in cell death. Mechanism of action: metabolites cause the alkylation of DNA.

Ifosfamide, a structural analog of cyclophosphamide, belongs to the oxazaphosphorine class of antitumor alkylating agents which must be activated by the mixed-function oxidase system of the liver. The 4-hydroxy oxazaphosphorines are a reactive species capable of interacting with nucleic acids & cellular materials to cause cell damage & death. The 4-hydroxy metabolite spontaneously liberates acrolein in many sites throughout the body & it is this substance that is responsible for oxazaphosphorine urotoxicity. Both ifosfamide & cyclophosphamide produce cystitis characterized by tissue edema & ulceration followed by sloughing of mucosal epithelial cells, necrosis of smooth muscle fibers & arteries, & culminating in focal hemorrhage. The selective urotoxicity of oxazaphosphorine occurs because the bladder contains a very low content of thiol cmpds (glutathione, cysteine) which, by virtue of their nucleophilic sulfhydryl groups, are able to react & neutralize many reactive chemicals. Because the metabolic activation of ifosfamide proceeds more slowly than that of cyclophosphamide, doses of ifosfamide are 3-4 times higher than those of cyclophosphamide. This explains the higher incidence of urotoxicity associated with ifosfamide.

Ifosfamide requires activation by microsomal liver enzymes to active metabolites in order to exert its cytotoxic effects. Activation occurs by hydroxylation at the ring carbon atom 4 to form the unstable intermediate 4-hydroxyifosfamide. This metabolite then rapidly degrades to the stable urinary metabolite 4-ketoifosfamide. The stable urinary metabolite, 4-carboxyifosfamide, is formed upon the opening of the ring. These urinary metabolites have not been found to be cytotoxic. N, N-bis (2-chloroethyl)-phosphoric acid diamide (phosphoramide) and acrolein are also found. The major urinary metabolites, dechloroethyl ifosfamide, and dechloroethyl cyclophosphamide are formed upon enzymatic oxidation of the chloroethyl side chains and subsequent dealkylation. It is the alkylated metabolites of ifosfamide that have been shown to interact with DNA. Ifosfamide is cycle-phase nonspecific.

Indications

Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin’s lymphoma.
Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer.
Ifosfamide is an alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteosarcoma, bladder cancer, small cell lung cancer, and non-Hodgkin’s lymphoma.
Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin’s lymphoma.
Bladder Cancer, Cancer
Cervical Cancer
Ewing’s Sarcoma
Head and Neck Carcinoma
Lymphoma, Hodgkins
Malignant Neoplasm of Pancreas
Non-Hodgkin’s Lymphoma (NHL)
Osteosarcoma
Ovarian Cancer
Small Cell Lung Cancer (SCLC)
Soft Tissue Sarcoma
Testicular Germ Cell Cancer
Advanced thymic carcinoma

Use in Cancer.gov

Ifosfamide is approved to be used with other drugs to treat:

Testicular germ cell tumors that are malignant. It is used in patients who have already been treated with two other types of chemotherapy.

Ifosfamide is also being studied in the treatment of other types of cancer.

Therapeutic Uses

Ifosfamide currently is approved for use in combination with other drugs for germ-cell testicular cancer & is widely used to treat pediatric & adult sarcomas. Clinical trials also have shown ifosfamide to be active against carcinomas of the cervix & lung & against lymphomas. It is a common component of high-dose chemotherapy regimens with bone marrow or stem cell rescue; in these regimens, in total doses of 12-14 g/sq m, it may cause severe neurological toxicity, including coma & death. This toxicity is thought to result from a metabolite, chloracetaldehyde. In addition to hemorrhagic cystitis, ifosfamide causes nausea, vomiting, anorexia, leukopenia, nephrotoxicity, & CNS disturbances (especially somnolence & confusion).
Ifosfamide is indicated, in combination with other antineoplastic agents and a prophylactic agent against hemorrhagic cystitis (such as mesna), for the treatment of germ cell testicular tumors.
Ifosfamide is indicated as reasonable medical therapy for the treatment of head and neck carcinoma.
Ifosfamide is used for the treatment of soft-tissue sarcomas, Ewing’s sarcoma, and Hodgkin’s and non-Hodgkin’s lymphomas.
Ifosfamide is indicated for the treatment of breast carcinomas, cervical carcinoma, small cell lung carcinoma, non-small cell lung carcinoma, ovarian epithelial carcinoma, acute lymphocytic leukemia, neuroblastoma, and osteosarcoma.
Ifosfamide, in combination therapy, is considered reasonable medical therapy at some point in the management of germ-cell ovarian tumors. (Evidence rating: IIID).
Ifosfamide, alone and in combination with other chemotherapeutic agents, is considered reasonable medical therapy at some point in the management of bladder carcinoma (Evidence rating: IIID) and endometrial carcinoma (Evidence rating IIIA).
Ifosfamide is indicated, alone or in combination with other chemotherapeutic agents, as second-line therapy for the treatment of Wilms’ tumor in patients who have not responded to or whose disease has progressed during previous treatment (Evidence rating: IIID).

FDA Approved Indications

Ifosfamide is an alkylating agent and an analog of cyclophosphamide, used as a single agent or in combination with other agents to treat a wide variety of malignancies. These malignancies include[rx]:

Germline tumor of the testis
Soft tissue sarcomas
Ewing sarcoma
Cervical cancer, either recurrent or metastatic
Advanced bladder carcinoma
Non-Hodgkin lymphoma
Hodgkin lymphoma
Small and nonsmall cell lung carcinoma
Osteosarcoma
Ovarian cancer
Thymic cancer

Among all these cancers, the Food and Drug Administration (FDA) has approved the drug only for germline tumors of the testis. The indications for the use of ifosfamide include:

Germline Tumor of the Testis – The FDA-approved regimen is ifosfamide and mesna at a 1.2 g/m²/day dose for five days, repeated every three weeks or following count recovery. When using ifosfamide and other chemotherapeutic drugs, mainly cisplatin, paclitaxel, or etoposide, there has been complete remission in about 21 to 26% of the treated population. Aggressive hydration (at least 2 liters oral or IV) is necessary during administration.
Soft Tissue Sarcomas (off-label use) – Noncomparative studies have shown that combination therapy with ifosfamide/mesna has demonstrated objective response rates of around 40% when used as induction therapy.[rx]
Ewing Sarcoma (off-label use) – Doses of ifosfamide vary based on the age group. Used alongside vincristine, etoposide, doxorubicin along with mesna in different regimens. Overall, survival is better with combination therapies. [rx]
Cervical Cancer, Recurrent, or Metastatic (off-label use) – Ifosfamide is dosed along with mesna at 1500 g/m2/day every three weeks. When used along with paclitaxel and cisplatin, the response rate was 18 to 45%.[rx]
Bladder Carcinoma: Mainly Advanced Carcinoma (off-label use) [rx]
Non-Hodgkin Lymphoma (off-label use) – Used in Burkitt lymphoma and diffuse large B cell lymphoma (DLBCL) as salvage therapy.
Hodgkin Lymphoma (off-label use) [rx] – Used in relapsed or refractory cases in the RICE regimen (rituximab, ifosfamide, carboplatin, and etoposide) along with mesna.
Small and Non-small-cell cancer[rx]: When used as maintenance or consolidation has been shown to have more benefits than standard regimens.
Osteosarcoma (off-label use)
Ovarian Cancer – Used in advanced stages that are platinum-resistant. Many additional trials are underway. Response rates have been more than 40% when used as a combination.
Thymic Cancer – Used in advanced stages of thymic cancer. [12]

Contraindications

There are very few known contraindications for the use of ifosfamide. The absolute contraindications are known hypersensitivity to the drug or its components and urinary tract outflow obstruction. Relative contraindications include myelosuppression and severe renal or hepatic impairment.
Known hypersensitivity to the drug and/or its components – can result in anaphylaxis with drug administration.[rx]
Urinary outflow obstruction – there is a high chance of developing cystitis when there is urinary tract obstruction due to an accumulation of toxic compounds.[rx]
Severe thrombocytopenia and leukopenia – due to the known toxic effect of hematologically, the drug is avoided in severe thrombocytopenia and leukopenia.
Severe renal or hepatic impairment – drug metabolism occurs in the liver, and the drug is excreted by the kidneys, prohibiting its use in severe renal and hepatic impairment.[rx]
cancer metastasis to bone
dehydration
low amount of potassium in the blood
Fanconi syndrome is a condition of the kidneys resulting in excessive urination, thirst, and vomiting
anemia
decreased blood platelets
low levels of white blood cells
confusion
generalized disorder of peripheral nerves
liver problems
renal tubular acidosis
decreased kidney function
inflammation and bleeding of the bladder due to chemotherapy
coma
the high amount of bilirubin in the blood
abnormal liver function tests
impaired wound healing
pregnancy
a patient who is producing milk and breastfeeding
the operation to remove kidney tissue

Dosage

Strengths: 1 g; 3 g; 50 mg/mL

Testicular Cancer

1.2 g/m2 IV over at least 30 minutes daily for 5 consecutive days; repeat every 3 weeks or after recovery from hematologic toxicity
To prevent bladder toxicity, this drug should be given with extensive hydration (at least 2 liters of oral or IV fluid daily). Mesna should be used to reduce hemorrhagic cystitis.
For germ-cell testicular cancer, the dosing regimen is 1.2 g/m²/day IV for the initial five days of a 21-day cycle. IV infusion is typically for a period of 30 minutes along with IV hydration and mesna to prevent bladder toxicity. Ifosfamide is emetogenic; hence, antiemetics are routinely prescribed to prevent chemotherapy-induced nausea and vomiting. Precipitation of ifosfamide-induced encephalopathy (IIE) by aprepitant has been reported in the literature. [rx][rx]

Side Effects

The Most Common

nausea
vomiting
loss of appetite
diarrhea
sores in the mouth and throat
hair loss
the general feeling of pain and tiredness
swelling, redness, and pain in the place where the medication was injected
rash
fever, chills, flu symptoms;
mouth and throat ulcers;
skin sores, pale skin, cold hands, and feet;
easy bruising, unusual bleeding
rapid heart rate, shallow breathing; or
little or no urination, painful or difficult urination, blood in your urine;
loss of bladder control; feeling light-headed or short of breath.
confusion, unusual thoughts or behavior, hallucinations, seizure (convulsions);
itching
difficulty breathing or swallowing
shortness of breath
wheezing
irregular heartbeat
chest pain
hoarseness
yellowing of the skin or eyes

More common

Agitation
black, tarry stools
blood in the urine
chest pain
confusion
cough or hoarseness
fever or chills
Diarrhea
hair loss or thinning of the hair
swelling or inflammation of the mouth
Redness, swelling, or pain at place of injection
weight loss
frequent urination
hallucinations (seeing, hearing, or feeling things that are not there)
lower back or side pain
painful or difficult urination
pale skin
shortness of breath
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swollen glands
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness

Rare

Abdominal or stomach pain or tenderness
bleeding gums
bluish color
changes in skin color
clay colored stools
dark urine
decreased appetite
dizziness
headache
itching
loss of appetite
nausea and vomiting
pain
pinpoint red spots on the skin
skin rash
swelling of the feet or lower legs
yellow eyes or skin
Blurred vision
burning, numbness, tingling, or painful sensations
confusion
convulsions (seizures)
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast or irregular heartbeat
sweating
troubled breathing
unsteadiness or awkwardness
weakness in the arms, hands, legs, or feet

Drug Interactions

Abacavir	Abacavir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Abametapir	The serum concentration of Ifosfamide can be increased when it is combined with Abametapir.
Abatacept	The metabolism of Ifosfamide can be increased when combined with Abatacept.
Abciximab	The risk or severity of bleeding can be increased when Ifosfamide is combined with Abciximab.
Abemaciclib	The metabolism of Abemaciclib can be increased when combined with Ifosfamide.
Abiraterone	The metabolism of Ifosfamide can be decreased when combined with Abiraterone.
Abrocitinib	The metabolism of Abrocitinib can be decreased when combined with Ifosfamide.
Acalabrutinib	The metabolism of Acalabrutinib can be increased when combined with Ifosfamide.
Aceclofenac	Aceclofenac may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Acenocoumarol	The risk or severity of bleeding can be increased when Ifosfamide is combined with Acenocoumarol.
Acetaminophen	The metabolism of Ifosfamide can be increased when combined with Acetaminophen.
Acetazolamide	The metabolism of Ifosfamide can be decreased when combined with Acetazolamide.
Acetohexamide	The metabolism of Ifosfamide can be decreased when combined with Acetohexamide.
Acetyl sulfisoxazole	The metabolism of Ifosfamide can be decreased when combined with Acetyl sulfisoxazole.
Acetyldigitoxin	Acetyldigitoxin may decrease the cardiotoxic activities of Ifosfamide.
Acetylsalicylic acid	The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Ifosfamide.
Aclidinium	Ifosfamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine	Ifosfamide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Adalimumab	The metabolism of Ifosfamide can be increased when combined with Adalimumab.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Adenovirus type	The risk or severity of infection can be increased when Adenovirus type 7 vaccine live is combined with Ifosfamide.
Agomelatine	The metabolism of Ifosfamide can be decreased when combined with Agomelatine.
Albendazole	The metabolism of Ifosfamide can be decreased when combined with Albendazole.
Albutrepenonacog	Ifosfamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac	Alclofenac may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Aldesleukin	The metabolism of Ifosfamide can be decreased when combined with Aldesleukin.
Alectinib	The metabolism of Alectinib can be increased when combined with Ifosfamide.
Alefacept	The risk or severity of adverse effects can be increased when Alefacept is combined with Ifosfamide.
Alemtuzumab	The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Ifosfamide.
Alfentanil	The metabolism of Ifosfamide can be decreased when combined with Alfentanil.
Alfuzosin	The metabolism of Alfuzosin can be decreased when combined with Ifosfamide.
Allogeneic	The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Ifosfamide.
Allopurinol	The risk or severity of adverse effects can be increased when Allopurinol is combined with Ifosfamide.
Almasilate	Ifosfamide may decrease the excretion rate of Almasilate which could result in a higher serum level.
Almotriptan	The metabolism of Almotriptan can be increased when combined with Ifosfamide.
Alogliptin	Ifosfamide may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Alosetron	The metabolism of Ifosfamide can be decreased when combined with Alosetron.
Alpelisib	The metabolism of Ifosfamide can be increased when combined with Alpelisib.
Alprazolam	The metabolism of Alprazolam can be decreased when combined with Ifosfamide.
Alteplase	The risk or severity of bleeding can be increased when Ifosfamide is combined with Alteplase.
Altretamine	The risk or severity of adverse effects can be increased when Altretamine is combined with Ifosfamide.
Amantadine	Amantadine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ambrisentan	The metabolism of Ifosfamide can be decreased when combined with Ambrisentan.
Amikacin	Ifosfamide may decrease the excretion rate of Amikacin which could result in a higher serum level.
Amiloride	Amiloride may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Aminoglutethimide	The metabolism of Ifosfamide can be increased when combined with Aminoglutethimide.
Aminophenazone	The metabolism of Aminophenazone can be increased when combined with Ifosfamide.
Aminophylline	The metabolism of Aminophylline can be increased when combined with Ifosfamide.
Aminosalicylic acid	The risk or severity of methemoglobinemia can be increased when Aminosalicylic acid is combined with Ifosfamide.
Amiodarone	The metabolism of Ifosfamide can be decreased when combined with Amiodarone.
Amitriptyline	The metabolism of Ifosfamide can be decreased when combined with Amitriptyline.
Amlodipine	The metabolism of Amlodipine can be increased when combined with Ifosfamide.
Ammonium chloride	Ifosfamide may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Amobarbital	The metabolism of Ifosfamide can be increased when combined with Amobarbital.
Amodiaquine	The metabolism of Amodiaquine can be increased when combined with Ifosfamide.
Amoxicillin	Amoxicillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Amphetamine	Amphetamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ampicillin	Ampicillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Amprenavir	The metabolism of Ifosfamide can be increased when combined with Amprenavir.
Amrinone	Ifosfamide may decrease the excretion rate of Amrinone which could result in a higher serum level.
Amsacrine	The risk or severity of adverse effects can be increased when Amsacrine is combined with Ifosfamide.
Amyl Nitrite	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Amyl Nitrite.
Anagrelide	The risk or severity of bleeding can be increased when Anagrelide is combined with Ifosfamide.
Anakinra	The metabolism of Ifosfamide can be increased when combined with Anakinra.
Anastrozole	The risk or severity of cardiotoxicity can be increased when Ifosfamide is combined with Anastrozole.
Ancestim	Ifosfamide may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ancrod	The risk or severity of bleeding can be increased when Ifosfamide is combined with Ancrod.
Anifrolumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Anifrolumab.
Anistreplase	The risk or severity of bleeding can be increased when Ifosfamide is combined with Anistreplase.
Anthrax immune	The therapeutic efficacy of Anthrax immune globulin human can be decreased when used in combination with Ifosfamide.
Anthrax vaccine	The risk or severity of infection can be increased when Anthrax vaccine is combined with Ifosfamide.
Antihemophilic	Ifosfamide may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.
Antilymphocyte	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Antilymphocyte immunoglobulin (horse).
Antipyrine	The metabolism of Ifosfamide can be decreased when combined with Antipyrine.
Antithrombin Alfa	The risk or severity of bleeding can be increased when Ifosfamide is combined with Antithrombin Alfa.
Antithrombin III	The risk or severity of bleeding can be increased when Ifosfamide is combined with Antithrombin III human.
Antithymocyte	The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Ifosfamide.
Antrafenine	Antrafenine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Apalutamide	The metabolism of Ifosfamide can be increased when combined with Apalutamide.
Apixaban	The risk or severity of bleeding can be increased when Ifosfamide is combined with Apixaban.
Apomorphine	The metabolism of Ifosfamide can be decreased when combined with Apomorphine.
Apremilast	The metabolism of Ifosfamide can be increased when combined with Apremilast.
Aprepitant	The metabolism of Ifosfamide can be decreased when combined with Aprepitant.
Ardeparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Ardeparin.
Arformoterol	The metabolism of Arformoterol can be decreased when combined with Ifosfamide.
Argatroban	The risk or severity of bleeding can be increased when Ifosfamide is combined with Argatroban.
Aripiprazole	The metabolism of Aripiprazole can be increased when combined with Ifosfamide.
Aripiprazole	The metabolism of Aripiprazole lauroxil can be increased when combined with Ifosfamide.
Armodafinil	The metabolism of Ifosfamide can be increased when combined with Armodafinil.
Arsenic trioxide	The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Ifosfamide.
Artemether	The metabolism of Ifosfamide can be increased when combined with Artemether.
Articaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Articaine.
Asciminib	The serum concentration of Ifosfamide can be increased when it is combined with Asciminib.
Astemizole	The metabolism of Astemizole can be increased when combined with Ifosfamide.
COVID-19 Vaccine	The therapeutic efficacy of AstraZeneca COVID-19 Vaccine can be decreased when used in combination with Ifosfamide.
Asunaprevir	The metabolism of Ifosfamide can be increased when combined with Asunaprevir.
Atazanavir	The metabolism of Ifosfamide can be decreased when combined with Atazanavir

Atomoxetine	Atomoxetine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Atorvastatin	The metabolism of Atorvastatin can be decreased when combined with Ifosfamide.
Atovaquone	The metabolism of Ifosfamide can be decreased when combined with Atovaquone.
Auranofin	Auranofin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Aurothioglucose	Ifosfamide may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
Avacopan	The metabolism of Ifosfamide can be decreased when combined with Avacopan.
Avanafil	The serum concentration of Avanafil can be increased when it is combined with Ifosfamide.
Avapritinib	The metabolism of Ifosfamide can be decreased when combined with Avapritinib.
Avatrombopag	The metabolism of Ifosfamide can be increased when combined with Avatrombopag.
Axitinib	The metabolism of Axitinib can be increased when combined with Ifosfamide.
Azacitidine	The risk or severity of adverse effects can be increased when Azacitidine is combined with Ifosfamide.
Azathioprine	The risk or severity of adverse effects can be increased when Azathioprine is combined with Ifosfamide.
Azelaic acid	Azelaic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Azelastine	The metabolism of Ifosfamide can be decreased when combined with Azelastine.
Azithromycin	The metabolism of Ifosfamide can be decreased when combined with Azithromycin.
Aztreonam	Aztreonam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Bacillus	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Ifosfamide.
Bacillusantigen	The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Ifosfamide.
Bacillus calmette	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Ifosfamide.
Bacitracin	Bacitracin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Baclofen	Baclofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Baricitinib	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Baricitinib.
Basiliximab	The risk or severity of adverse effects can be increased when Basiliximab is combined with Ifosfamide.
BCG vaccine	The risk or severity of infection can be increased when BCG vaccine is combined with Ifosfamide.
Beclomethasone	The metabolism of Ifosfamide can be increased when combined with Beclomethasone dipropionate.
Belatacept	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belatacept.
Belimumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belimumab.
Belinostat	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belinostat.
Belumosudil	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Belumosudil.
Belzutifan	The serum concentration of Ifosfamide can be decreased when it is combined with Belzutifan.
Bemiparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Bemiparin.
Bendamustine	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Bendamustine.
Bendroflumethiazide	Bendroflumethiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Benorilate	Benorilate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Benserazide	Ifosfamide may decrease the excretion rate of Benserazide which could result in a higher serum level.
Benzatropine	Benzatropine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Benznidazole	Ifosfamide may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Benzocaine.
Benzphetamine	The metabolism of Ifosfamide can be decreased when combined with Benzphetamine.
Benzthiazide	Benzthiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Benzydamine	Benzydamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Benzyl alcohol.
Bepotastine	Ifosfamide may decrease the excretion rate of Bepotastine which could result in a higher serum level.
Berotralstat	The serum concentration of Ifosfamide can be increased when it is combined with Berotralstat.
Betamethasone	The metabolism of Ifosfamide can be increased when combined with Betamethasone.
Betamethasone	The metabolism of Ifosfamide can be increased when combined with Betamethasone phosphate.
Betrixaban	The risk or severity of bleeding can be increased when Ifosfamide is combined with Betrixaban.
Bevacizumab	The risk or severity of cardiotoxicity can be increased when Bevacizumab is combined with Ifosfamide.
Bexarotene	The metabolism of Ifosfamide can be increased when combined with Bexarotene.
Bezafibrate	The metabolism of Ifosfamide can be decreased when combined with Bezafibrate.
Bicalutamide	The metabolism of Bicalutamide can be increased when combined with Ifosfamide.
Bicisate	Ifosfamide may decrease the excretion rate of Bicisate which could result in a higher serum level.
Bifonazole	The metabolism of Ifosfamide can be decreased when combined with Bifonazole.
Bimekizumab	The metabolism of Ifosfamide can be increased when combined with Bimekizumab.
Bismuth	Ifosfamide may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
Bisoprolol	Bisoprolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Bisoxatin	Ifosfamide may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
Bivalirudin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Bivalirudin.
Bleomycin	The risk or severity of adverse effects can be increased when Bleomycin is combined with Ifosfamide.
Blinatumomab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Blinatumomab.
Boceprevir	The metabolism of Ifosfamide can be decreased when combined with Boceprevir.
Bordetella	The therapeutic efficacy of Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) can be decreased when used in combination with Ifosfamide.
Bortezomib	The metabolism of Bortezomib can be increased when combined with Ifosfamide.
Bosentan	The metabolism of Ifosfamide can be increased when combined with Bosentan.
Bosutinib	The metabolism of Bosutinib can be increased when combined with Ifosfamide.
Brentuximab vedotin	The metabolism of Brentuximab vedotin can be increased when combined with Ifosfamide.
Brigatinib	The metabolism of Ifosfamide can be increased when combined with Brigatinib.
Brivaracetam	The metabolism of Ifosfamide can be decreased when combined with Brivaracetam.
Brodalumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Brodalumab.
Bromazepam	Ifosfamide may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Bromotheophylline	Bromotheophylline may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Brompheniramine	The metabolism of Ifosfamide can be decreased when combined with Brompheniramine.
Budesonide	The metabolism of Ifosfamide can be increased when combined with Budesonide.
Bumadizone	Bumadizone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Bumetanide	Bumetanide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Bupivacaine.
Buprenorphine	The metabolism of Ifosfamide can be decreased when combined with Buprenorphine.
Bupropion	The metabolism of Ifosfamide can be decreased when combined with Bupropion.
Buspirone	The metabolism of Ifosfamide can be decreased when combined with Buspirone.
Busulfan	The risk or severity of hemorrhagic cystitis can be increased when Busulfan is combined with Ifosfamide.
Butabarbital	Butabarbital may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Butacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Butacaine.
Butalbital	The metabolism of Ifosfamide can be increased when combined with Butalbital.
Butamben	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Butamben.
Cabazitaxel	The metabolism of Cabazitaxel can be increased when combined with Ifosfamide.
Cabergoline	The metabolism of Cabergoline can be increased when combined with Ifosfamide.
Cabozantinib	The metabolism of Ifosfamide can be decreased when combined with Cabozantinib.
Calcitriol	The metabolism of Ifosfamide can be increased when combined with Calcitriol.
Canagliflozin	Canagliflozin may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Canakinumab	The metabolism of Ifosfamide can be increased when combined with Canakinumab.
Candesartan	The metabolism of Ifosfamide can be decreased when combined with Candesartan cilexetil.
Candicidin	The metabolism of Ifosfamide can be decreased when combined with Candicidin.
Cangrelor	The risk or severity of bleeding can be increased when Ifosfamide is combined with Cangrelor.
Cannabidiol	The metabolism of Ifosfamide can be decreased when combined with Cannabidiol.
Canrenoic acid	Canrenoic acid may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Capecitabine	The risk or severity of adverse effects can be increased when Capecitabine is combined with Ifosfamide.
Caplacizumab	The risk or severity of bleeding can be increased when Caplacizumab is combined with Ifosfamide.
Capmatinib	The serum concentration of Capmatinib can be decreased when it is combined with Ifosfamide.

Capreomycin	Ifosfamide may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Capsaicin.
Carbamazepine	The metabolism of Ifosfamide can be increased when combined with Carbamazepine.
Carbidopa	Carbidopa may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Carboplatin	The risk or severity of adverse effects can be increased when Carboplatin is combined with Ifosfamide.
Carfilzomib	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Carfilzomib.
Carmustine	The risk or severity of adverse effects can be increased when Carmustine is combined with Ifosfamide.
Carprofen	Carprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Carvedilol	The metabolism of Ifosfamide can be decreased when combined with Carvedilol.
Cefaclor	Cefaclor may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefdinir	Cefdinir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefepime	Cefepime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefoperazone	Cefoperazone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefpirome	Cefpirome may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefradine	The metabolism of Ifosfamide can be increased when combined with Cefradine.
Ceftaroline	Ceftaroline fosamil may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceftolozane	Ifosfamide may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
Ceftriaxone	Ceftriaxone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Celecoxib	The risk or severity of methemoglobinemia can be increased when Celecoxib is combined with Ifosfamide.
Cenobamate	The metabolism of Ifosfamide can be increased when combined with Cenobamate.
Cephalexin	The metabolism of Ifosfamide can be decreased when combined with Cephalexin.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ceritinib	The metabolism of Ceritinib can be increased when combined with Ifosfamide.
Cerivastatin	The metabolism of Ifosfamide can be increased when combined with Cerivastatin.
Certolizumab	The metabolism of Ifosfamide can be increased when combined with Certolizumab pegol.
Cetirizine	Cetirizine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cevimeline	Cevimeline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Chloral hydrate	Ifosfamide may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Chlorambucil	The risk or severity of adverse effects can be increased when Chlorambucil is combined with Ifosfamide.
Chloramphenicol	The metabolism of Ifosfamide can be decreased when combined with Chloramphenicol.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Chloroprocaine.
Chloroquine	The metabolism of Ifosfamide can be decreased when combined with Chloroquine.
Chlorothiazide	Chlorothiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Chloroxylenol	Ifosfamide may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
Chlorpheniramine	The metabolism of Ifosfamide can be decreased when combined with Chlorpheniramine.
Chlorpromazine	The metabolism of Ifosfamide can be increased when combined with Chlorpromazine.
Chlorpropamide	Chlorpropamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Chlorthalidone	Chlorthalidone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorzoxazone	The metabolism of Ifosfamide can be decreased when combined with Chlorzoxazone.
Choline C 11	Ifosfamide may decrease the excretion rate of Choline C 11 which could result in a higher serum level.
Choline magnesi	Choline magnesium trisalicylate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Choline salicylate	Ifosfamide may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
Chondroitin sulfate	Ifosfamide may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
Chromic chloride	Ifosfamide may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
Chromic nitrate	Ifosfamide may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
Chromium	Ifosfamide may decrease the excretion rate of Chromium which could result in a higher serum level.
Chromium gluconate	Ifosfamide may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
Chromium nicotinate	Ifosfamide may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
Chromous sulfate	Ifosfamide may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
Ciclesonide	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ciclesonide.
Cidofovir	Cidofovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Cilostazol	The metabolism of Cilostazol can be decreased when combined with Ifosfamide.
Cimetidine	The metabolism of Ifosfamide can be decreased when combined with Cimetidine.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Cinchocaine.
Cinnarizine	The metabolism of Ifosfamide can be decreased when combined with Cinnarizine.
Ciprofloxacin	The metabolism of Ifosfamide can be decreased when combined with Ciprofloxacin.
Cisapride	The metabolism of Ifosfamide can be decreased when combined with Cisapride.
Cisplatin	The metabolism of Ifosfamide can be decreased when combined with Cisplatin.
Citalopram	The metabolism of Ifosfamide can be decreased when combined with Citalopram.
Cladribine	The risk or severity of adverse effects can be increased when Cladribine is combined with Ifosfamide.
Clarithromycin	The metabolism of Ifosfamide can be decreased when combined with Clarithromycin.
Clevidipine	The metabolism of Ifosfamide can be increased when combined with Clevidipine.
Clindamycin	The metabolism of Clindamycin can be increased when combined with Ifosfamide.
Clobazam	The metabolism of Ifosfamide can be increased when combined with Clobazam.
Clobetasol	The metabolism of Ifosfamide can be increased when combined with Clobetasol propionate.
Clofarabine	The risk or severity of adverse effects can be increased when Clofarabine is combined with Ifosfamide.
Clofazimine	The metabolism of Ifosfamide can be decreased when combined with Clofazimine.
Clofibrate	The metabolism of Ifosfamide can be increased when combined with Clofibrate.
Clomipramine	The metabolism of Clomipramine can be increased when combined with Ifosfamide.
Clonazepam	The metabolism of Clonazepam can be increased when combined with Ifosfamide.
Clonidine	The metabolism of Clonidine can be increased when combined with Ifosfamide.
Clopidogrel	The metabolism of Ifosfamide can be decreased when combined with Clopidogrel.
Clorazepic acid	Clorazepic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Clostridium	The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Ifosfamide.
Clotiazepam	The metabolism of Ifosfamide can be decreased when combined with Clotiazepam.
Clove oil	Ifosfamide may decrease the excretion rate of Clove oil which could result in a higher serum level.
Clozapine	The metabolism of Ifosfamide can be increased when combined with Clozapine.
Cobicistat	The metabolism of Ifosfamide can be decreased when combined with Cobicistat.

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Cobimetinib	The metabolism of Cobimetinib can be increased when combined with Ifosfamide.
Cocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Cocaine.
Colchicine	The metabolism of Colchicine can be decreased when combined with Ifosfamide.
Colistimethate	Colistimethate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Colistin	Ifosfamide may decrease the excretion rate of Colistin which could result in a higher serum level.
Conivaptan	The metabolism of Ifosfamide can be decreased when combined with Conivaptan.
Conjugated	Conjugated estrogens may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Copanlisib	The metabolism of Copanlisib can be increased when combined with Ifosfamide.
Corifollitropin alfa	Ifosfamide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
Corticotropin	The metabolism of Ifosfamide can be increased when combined with Corticotropin.
Cortisone acetate	The metabolism of Ifosfamide can be increased when combined with Cortisone acetate.
Corynebacterium	The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Ifosfamide.
Crizotinib	The metabolism of Ifosfamide can be decreased when combined with Crizotinib.
Curcumin	The metabolism of Ifosfamide can be decreased when combined with Curcumin.
Cyanocobalamin	The therapeutic efficacy of Cyanocobalamin can be decreased when used in combination with Ifosfamide.
Cyclizine	The metabolism of Ifosfamide can be decreased when combined with Cyclizine.
Cyclopenthiazide	Cyclopenthiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Cyclophosphamide	The metabolism of Ifosfamide can be increased when combined with Cyclophosphamide.
Cyclosporine	Ifosfamide may increase the immunosuppressive activities of Cyclosporine.
Cyclothiazide	Cyclothiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Cyproterone	The metabolism of Ifosfamide can be decreased when combined with Cyproterone acetate.
Cytarabine	The risk or severity of adverse effects can be increased when Cytarabine is combined with Ifosfamide.
Dabigatran	The risk or severity of bleeding can be increased when Ifosfamide is combined with Dabigatran.
Dabigatran	The risk or severity of bleeding can be increased when Ifosfamide is combined with Dabigatran etexilate.
Dabrafenib	The metabolism of Ifosfamide can be increased when combined with Dabrafenib.
Dacarbazine	The risk or severity of adverse effects can be increased when Dacarbazine is combined with Ifosfamide.
Daclatasvir	The metabolism of Ifosfamide can be decreased when combined with Daclatasvir.
Dacomitinib	The metabolism of Dacomitinib can be increased when combined with Ifosfamide.
Dactinomycin	The risk or severity of adverse effects can be increased when Dactinomycin is combined with Ifosfamide.
Dalfampridine	Ifosfamide may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Dalfopristin	The metabolism of Ifosfamide can be decreased when combined with Dalfopristin.
Dalteparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Dalteparin.
Danaparoid	The risk or severity of bleeding can be increased when Ifosfamide is combined with Danaparoid.
Danazol	The metabolism of Ifosfamide can be decreased when combined with Danazol.
Dapagliflozin	Dapagliflozin may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Dapsone	The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Ifosfamide.
Daptomycin	Daptomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Darbepoetin	The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Ifosfamide.
Darunavir	The serum concentration of Ifosfamide can be increased when it is combined with Darunavir.
Dasabuvir	The metabolism of Dasabuvir can be increased when combined with Ifosfamide.
Dasatinib	The metabolism of Dasatinib can be increased when combined with Ifosfamide.
Daunorubicin	The metabolism of Ifosfamide can be decreased when combined with Daunorubicin.
Decitabine	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Decitabine.
Deferasirox	The metabolism of Ifosfamide can be increased when combined with Deferasirox.
Deferiprone	Ifosfamide may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Defibrotide	The risk or severity of bleeding can be increased when Ifosfamide is combined with Defibrotide.
Deflazacort	The metabolism of Ifosfamide can be increased when combined with Deflazacort.
Delafloxacin	The metabolism of Ifosfamide can be increased when combined with Delafloxacin.
Delavirdine	The metabolism of Ifosfamide can be decreased when combined with Delavirdine.
Denosumab	The risk or severity of adverse effects can be increased when Denosumab is combined with Ifosfamide.
Desipramine	The metabolism of Ifosfamide can be decreased when combined with Desipramine.
Desirudin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Desirudin.
Deslanoside	Deslanoside may decrease the cardiotoxic activities of Ifosfamide.
Desmopressin	Desmopressin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Desogestrel	The metabolism of Desogestrel can be increased when combined with Ifosfamide.
Desoximetasone	The risk or severity of adverse effects can be increased when Desoximetasone is combined with Ifosfamide.
Desvenlafaxine	The metabolism of Ifosfamide can be decreased when combined with Desvenlafaxine.
Deucravacitinib	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Deucravacitinib.
Deutetrabenazine	The metabolism of Ifosfamide can be decreased when combined with Deutetrabenazine.
Dexamethasone	The metabolism of Ifosfamide can be increased when combined with Dexamethasone.
Dexamethasone	The metabolism of Ifosfamide can be increased when combined with Dexamethasone acetate.
Dexibuprofen	The metabolism of Dexibuprofen can be increased when combined with Ifosfamide.
Dexketoprofen	Dexketoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Dexmedetomidine	Dexmedetomidine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Dexpanthenol	Ifosfamide may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
Dexrazoxane	The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Ifosfamide.
Dextran	The risk or severity of bleeding can be increased when Ifosfamide is combined with Dextran.
Dextromethorphan	The metabolism of Ifosfamide can be decreased when combined with Dextromethorphan.
Dextropropoxyphene	The metabolism of Ifosfamide can be decreased when combined with Dextropropoxyphene.
Diacerein	The metabolism of Ifosfamide can be decreased when combined with Diacerein.
Diatrizoate	Diatrizoate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Diazepam	The metabolism of Ifosfamide can be decreased when combined with Diazepam.
Dichlorobenzyl	Ifosfamide may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Diclofenac	The metabolism of Ifosfamide can be decreased when combined with Diclofenac.
Diclofenamide	Diclofenamide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Dicloxacillin	The metabolism of Ifosfamide can be increased when combined with Dicloxacillin.
Dicoumarol	The risk or severity of bleeding can be increased when Ifosfamide is combined with Dicoumarol.
Dicyclomine	Dicyclomine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Didanosine	Didanosine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Dienogest	The metabolism of Dienogest can be increased when combined with Ifosfamide.
Diethylstilbestrol	The metabolism of Ifosfamide can be decreased when combined with Diethylstilbestrol.
Diflunisal	Diflunisal may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Difluocortolone	The metabolism of Ifosfamide can be increased when combined with Difluocortolone.
Digitoxin	The metabolism of Digitoxin can be increased when combined with Ifosfamide.
Digoxin	Ifosfamide may decrease the excretion rate of Digoxin which could result in a higher serum level.
Dihydroergocornine	The metabolism of Ifosfamide can be decreased when combined with Dihydroergocornine.
Dihydroergocristine	The metabolism of Ifosfamide can be decreased when combined with Dihydroergocristine.
Dihydroergotamine	The metabolism of Dihydroergotamine can be increased when combined with Ifosfamide.
Dihydrostreptomycin	Dihydrostreptomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Diltiazem	The metabolism of Ifosfamide can be decreased when combined with Diltiazem.
Dimercaprol	Ifosfamide may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
Dimethyl fumarate	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Dimethyl fumarate.
Dimethyl sulfoxide	The metabolism of Ifosfamide can be decreased when combined with Dimethyl sulfoxide.
Dinutuximab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Dinutuximab.
Diosmin	The metabolism of Ifosfamide can be decreased when combined with Diosmin.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Diphenhydramine.
Dipyridamole	The risk or severity of bleeding can be increased when Ifosfamide is combined with Dipyridamole.
Diroximel fumarate	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Diroximel fumarate.
Disopyramide	Disopyramide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Disulfiram	The metabolism of Ifosfamide can be decreased when combined with Disulfiram

Dobutamine	Dobutamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Docetaxel	The metabolism of Docetaxel can be increased when combined with Ifosfamide.
Doconexent	The metabolism of Ifosfamide can be decreased when combined with Doconexent.
Dofetilide	The metabolism of Dofetilide can be increased when combined with Ifosfamide.
Domperidone	The metabolism of Ifosfamide can be decreased when combined with Domperidone.
Donepezil	The metabolism of Ifosfamide can be decreased when combined with Donepezil.
Dopamine	Dopamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Doravirine	The metabolism of Ifosfamide can be decreased when combined with Doravirine.
Doripenem	Ifosfamide may decrease the excretion rate of Doripenem which could result in a higher serum level.
Dosulepin	The metabolism of Dosulepin can be decreased when combined with Ifosfamide.
Doxacurium	Doxacurium may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Doxazosin	The metabolism of Ifosfamide can be decreased when combined with Doxazosin.
Doxepin	Doxepin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Doxorubicin	The metabolism of Doxorubicin can be increased when combined with Ifosfamide.
Doxycycline	Doxycycline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Dronabinol	The serum concentration of Dronabinol can be increased when it is combined with Ifosfamide.
Dronedarone	The serum concentration of Ifosfamide can be increased when it is combined with Dronedarone.
Drospirenone	The metabolism of Ifosfamide can be decreased when combined with Drospirenone.
Drotrecogin alfa	The risk or severity of bleeding can be increased when Ifosfamide is combined with Drotrecogin alfa.
Droxidopa	Ifosfamide may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Duloxetine	Duloxetine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Dutasteride	The metabolism of Ifosfamide can be decreased when combined with Dutasteride.
Duvelisib	The metabolism of Ifosfamide can be decreased when combined with Duvelisib.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Dyclonine.
Dyphylline	Dyphylline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ebastine	The metabolism of Ifosfamide can be decreased when combined with Ebastine.
Ebola Zaire	The therapeutic efficacy of Ebola Zaire vaccine (live, attenuated) can be decreased when used in combination with Ifosfamide.
Echinacea	The metabolism of Ifosfamide can be increased when combined with Echinacea.
Eculizumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Eculizumab.
Edetic acid	The risk or severity of bleeding can be increased when Ifosfamide is combined with Edetic acid.
Edoxaban	The risk or severity of bleeding can be increased when Ifosfamide is combined with Edoxaban.
Edrophonium	Edrophonium may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Efalizumab	The risk or severity of adverse effects can be increased when Efalizumab is combined with Ifosfamide.
Efavirenz	The metabolism of Ifosfamide can be increased when combined with Efavirenz.
Elagolix	The metabolism of Elagolix can be increased when combined with Ifosfamide.
Elbasvir	The metabolism of Ifosfamide can be decreased when combined with Elbasvir.
Eletriptan	The metabolism of Ifosfamide can be increased when combined with Eletriptan.
Elexacaftor	The metabolism of Ifosfamide can be decreased when combined with Elexacaftor.
Eliglustat	The metabolism of Eliglustat can be decreased when combined with Ifosfamide.
Eltrombopag	The metabolism of Ifosfamide can be decreased when combined with Eltrombopag.
Elvitegravir	The metabolism of Ifosfamide can be decreased when combined with Elvitegravir.
Emapalumab	The metabolism of Ifosfamide can be increased when combined with Emapalumab.
Enalaprilat	Ifosfamide may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
Enasidenib	The metabolism of Ifosfamide can be increased when combined with Enasidenib.
Enoxaparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Enoxaparin.
Entrectinib	The metabolism of Entrectinib can be increased when combined with Ifosfamide.
Enzalutamide	The metabolism of Ifosfamide can be increased when combined with Enzalutamide.
Epinastine	The metabolism of Ifosfamide can be decreased when combined with Epinastine.
Epinephrine	The metabolism of Ifosfamide can be decreased when combined with Epinephrine.
Epirubicin	The risk or severity of adverse effects can be increased when Epirubicin is combined with Ifosfamide.
Eplerenone	The metabolism of Ifosfamide can be decreased when combined with Eplerenone.
Epoprostenol	The risk or severity of bleeding can be increased when Ifosfamide is combined with Epoprostenol.
Eptifibatide	The risk or severity of bleeding can be increased when Eptifibatide is combined with Ifosfamide.
Erdafitinib	The metabolism of Erdafitinib can be increased when combined with Ifosfamide.
Ergotamine	The metabolism of Ifosfamide can be decreased when combined with Ergotamine.
Eribulin	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Eribulin.
Erlotinib	The serum concentration of Erlotinib can be decreased when it is combined with Ifosfamide.
Ertapenem	Ertapenem may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ertugliflozin	Ertugliflozin may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Erythromycin	The metabolism of Ifosfamide can be decreased when combined with Erythromycin.
Erythropoietin	The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Ifosfamide.
Esketamine	The metabolism of Ifosfamide can be increased when combined with Esketamine.
Eslicarbazepine	The metabolism of Ifosfamide can be increased when combined with Eslicarbazepine.
Eslicarbazepine acetate	The metabolism of Ifosfamide can be increased when combined with Eslicarbazepine acetate.
Estazolam	Ifosfamide may decrease the excretion rate of Estazolam which could result in a higher serum level.
Estetrol	The metabolism of Ifosfamide can be decreased when combined with Estetrol.
Estradiol	The metabolism of Ifosfamide can be decreased when combined with Estradiol.
Estradiol acetate	The metabolism of Ifosfamide can be increased when combined with Estradiol acetate.
Estradiol benzoate	The metabolism of Ifosfamide can be increased when combined with Estradiol benzoate.
Estradiol cypionate	The metabolism of Ifosfamide can be increased when combined with Estradiol cypionate.
Estradiol dienanthate	The metabolism of Ifosfamide can be increased when combined with Estradiol dienanthate.
Estradiol valerate	The metabolism of Ifosfamide can be increased when combined with Estradiol valerate.
Estramustine	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Estramustine.
Estrone sulfate	The metabolism of Estrone sulfate can be increased when combined with Ifosfamide.
Eszopiclone	The serum concentration of Eszopiclone can be decreased when it is combined with Ifosfamide.
Etacrynic acid	Etacrynic acid may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Etafedrine	Ifosfamide may decrease the excretion rate of Etafedrine which could result in a higher serum level.
Etanercept	The metabolism of Ifosfamide can be increased when combined with Etanercept.
Ethambutol	The metabolism of Ifosfamide can be decreased when combined with Ethambutol.
Ethanol	The metabolism of Ifosfamide can be increased when combined with Ethanol.
Ethinylestradiol	The metabolism of Ifosfamide can be decreased when combined with Ethinylestradiol.
Ethotoin	The metabolism of Ifosfamide can be increased when combined with Ethotoin.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Ethyl chloride.
Ethynodiol diacetate	The metabolism of Ethynodiol diacetate can be increased when combined with Ifosfamide.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Etidocaine.
Etodolac	Etodolac may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Etomidate	Etomidate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Etonogestrel	The metabolism of Etonogestrel can be increased when combined with Ifosfamide.
Etoposide	The metabolism of Ifosfamide can be increased when combined with Etoposide.
Etoricoxib	The metabolism of Ifosfamide can be decreased when combined with Etoricoxib.
Etravirine	The metabolism of Ifosfamide can be increased when combined with Etravirine.
Eucalyptus oil	Ifosfamide may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
Everolimus	The metabolism of Everolimus can be increased when combined with Ifosfamide.
Ezogabine	Ifosfamide may decrease the excretion rate of Ezogabine which could result in a higher serum level.
Famtozinameran	The therapeutic efficacy of Famtozinameran can be decreased when used in combination with Ifosfamide.
Favipiravir	The metabolism of Ifosfamide can be decreased when combined with Favipiravir.
Felbamate	The metabolism of Ifosfamide can be increased when combined with Felbamate.
Felodipine	The metabolism of Ifosfamide can be decreased when combined with Felodipine.
Fenbufen	Fenbufen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.

Fenfluramine	The metabolism of Ifosfamide can be decreased when combined with Fenfluramine.
Fenofibrate	The metabolism of Ifosfamide can be decreased when combined with Fenofibrate.
Fenofibric acid	Ifosfamide may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
Fenoldopam	Fenoldopam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Fentanyl	The metabolism of Fentanyl can be decreased when combined with Ifosfamide.
Fesoterodine	Ifosfamide may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Fexinidazole	The metabolism of Ifosfamide can be decreased when combined with Fexinidazole.
Filgotinib	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Filgotinib.
Finasteride	The metabolism of Ifosfamide can be decreased when combined with Finasteride.
Finerenone	The serum concentration of Finerenone can be increased when it is combined with Ifosfamide.
Fingolimod	Ifosfamide may increase the immunosuppressive activities of Fingolimod.
Flavoxate	Flavoxate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Flecainide	The metabolism of Ifosfamide can be decreased when combined with Flecainide.
Floctafenine	Floctafenine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Florbetaben (18F)	Ifosfamide may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
Florbetapir (18F)	Ifosfamide may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
Floxuridine	The risk or severity of adverse effects can be increased when Floxuridine is combined with Ifosfamide.
Flucloxacillin	The metabolism of Ifosfamide can be increased when combined with Flucloxacillin.
Fluconazole	The metabolism of Ifosfamide can be decreased when combined with Fluconazole.
Flucytosine	The risk or severity of adverse effects can be increased when Flucytosine is combined with Ifosfamide.
Fludarabine	The risk or severity of adverse effects can be increased when Fludarabine is combined with Ifosfamide.
Fludeoxyglucose	Ifosfamide may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Fludrocortisone	The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Ifosfamide.
Fluindione	The risk or severity of bleeding can be increased when Ifosfamide is combined with Fluindione.
Flumazenil	Ifosfamide may decrease the excretion rate of Flumazenil which could result in a higher serum level.
Flunarizine	The metabolism of Flunarizine can be decreased when combined with Ifosfamide.
Flunisolide	The metabolism of Ifosfamide can be increased when combined with Flunisolide.
Flunitrazepam	The metabolism of Ifosfamide can be decreased when combined with Flunitrazepam.
Fluocinolone	The metabolism of Ifosfamide can be increased when combined with Fluocinolone acetonide.
Fluocinonide	The metabolism of Ifosfamide can be increased when combined with Fluocinonide.
Fluocortolone	The metabolism of Ifosfamide can be increased when combined with Fluocortolone.
Fluorometholone	The risk or severity of adverse effects can be increased when Fluorometholone is combined with Ifosfamide.
Fluorouracil	The metabolism of Fluorouracil can be increased when combined with Ifosfamide.
Fluoxetine	The metabolism of Ifosfamide can be decreased when combined with Fluoxetine.
Flupentixol	The risk or severity of myelosuppression can be increased when Flupentixol is combined with Ifosfamide.
Fluprednisolone	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Fluprednisolone.
Flurazepam	The metabolism of Ifosfamide can be decreased when combined with Flurazepam.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Flutamide	The metabolism of Ifosfamide can be decreased when combined with Flutamide.
Fluticasone	The metabolism of Ifosfamide can be increased when combined with Fluticasone.
Fluticasone furoate	The metabolism of Ifosfamide can be increased when combined with Fluticasone furoate.
Fluticasone	The metabolism of Ifosfamide can be decreased when combined with Fluticasone propionate.
Fluvastatin	The metabolism of Ifosfamide can be decreased when combined with Fluvastatin.
Fluvoxamine	The metabolism of Ifosfamide can be decreased when combined with Fluvoxamine.
Folic acid	Folic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Fomepizole	The metabolism of Ifosfamide can be decreased when combined with Fomepizole.
Fondaparinux	The risk or severity of bleeding can be increased when Ifosfamide is combined with Fondaparinux.
Formestane	The metabolism of Ifosfamide can be increased when combined with Formestane.
Formoterol	The metabolism of Ifosfamide can be decreased when combined with Formoterol.
Fosamprenavir	The metabolism of Ifosfamide can be decreased when combined with Fosamprenavir.
Fosaprepitant	The metabolism of Ifosfamide can be increased when combined with Fosaprepitant.
Foscarnet	Foscarnet may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Fosfomycin	Fosfomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Fosinopril	Fosinopril may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Fosnetupitant	The metabolism of Ifosfamide can be decreased when combined with Fosnetupitant.
Fosphenytoin	The metabolism of Ifosfamide can be increased when combined with Fosphenytoin.
Fostamatinib	The metabolism of Ifosfamide can be decreased when combined with Fostamatinib.
Framycetin	Framycetin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Furosemide	Furosemide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Fusidic acid	The metabolism of Ifosfamide can be decreased when combined with Fusidic acid.
Gabapentin	Ifosfamide may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level.
Gadobenic acid	Gadobenic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Gadodiamide	Gadodiamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Gadofosveset	Ifosfamide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Gadopentetic acid	Gadopentetic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Gadoteric acid	Ifosfamide may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
Gadoteridol	Gadoteridol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Gallium nitrate	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Gallium nitrate.
Ganciclovir	Ganciclovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Gefitinib	The metabolism of Ifosfamide can be decreased when combined with Gefitinib.
Gemcitabine	The risk or severity of adverse effects can be increased when Gemcitabine is combined with Ifosfamide.
Gemfibrozil	The metabolism of Ifosfamide can be decreased when combined with Gemfibrozil.
Gemtuzumab	The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Ifosfamide.
Gentamicin	Ifosfamide may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gestrinone	The metabolism of Gestrinone can be increased when combined with Ifosfamide.
Gilteritinib	The metabolism of Ifosfamide can be decreased when combined with Gilteritinib.
Gimeracil	Ifosfamide may decrease the excretion rate of Gimeracil which could result in a higher serum level.
Ginkgo biloba	The metabolism of Ifosfamide can be decreased when combined with Ginkgo biloba.
Givosiran	Givosiran may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Glasdegib	The metabolism of Glasdegib can be increased when combined with Ifosfamide.
Glatiramer	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Glatiramer.
Glecaprevir	The metabolism of Ifosfamide can be decreased when combined with Glecaprevir.
Gliclazide	The metabolism of Ifosfamide can be decreased when combined with Gliclazide.
Glimepiride	The metabolism of Ifosfamide can be decreased when combined with Glimepiride.
Glipizide	Glipizide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Gliquidone	The metabolism of Gliquidone can be decreased when combined with Ifosfamide.
Glyburide	The metabolism of Ifosfamide can be decreased when combined with Glyburide.
Glycerol	The metabolism of Ifosfamide can be increased when combined with Glycerol phenylbutyrate.
Golimumab	The metabolism of Ifosfamide can be increased when combined with Golimumab.
Golodirsen	Ifosfamide may decrease the excretion rate of Golodirsen which could result in a higher serum level.
Goserelin	Goserelin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Griseofulvin	The metabolism of Ifosfamide can be increased when combined with Griseofulvin.
Guanethidine	Guanethidine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Guanfacine	Guanfacine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Guselkumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Guselkumab.
Haemophilus	The therapeutic efficacy of Haemophilus influenzae type B strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen can be decreased when used in combination with Ifosfamide.
Halofantrine	The metabolism of Ifosfamide can be decreased when combined with Halofantrine.
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Ifosfamide.
Halothane	The metabolism of Ifosfamide can be decreased when combined with Halothane.

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Ketamine	The metabolism of Ifosfamide can be increased when combined with Ketamine.
Ketazolam	The metabolism of Ifosfamide can be decreased when combined with Ketazolam.
Ketoconazole	The metabolism of Ifosfamide can be decreased when combined with Ketoconazole.
Ketoprofen	Ketoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ketorolac	The metabolism of Ketorolac can be increased when combined with Ifosfamide.
Labetalol	Labetalol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lacosamide	The metabolism of Ifosfamide can be decreased when combined with Lacosamide.
Lamivudine	Lamivudine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lamotrigine	Lamotrigine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lanreotide	The metabolism of Ifosfamide can be decreased when combined with Lanreotide.
Lansoprazole	The metabolism of Ifosfamide can be increased when combined with Lansoprazole.
Lapatinib	The metabolism of Ifosfamide can be decreased when combined with Lapatinib.
Latamoxef	Latamoxef may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ledipasvir	Ifosfamide may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
Lefamulin	The serum concentration of Ifosfamide can be increased when it is combined with Lefamulin.
Leflunomide	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Leflunomide.
Lemborexant	The serum concentration of Lemborexant can be decreased when it is combined with Ifosfamide.
Lenalidomide	The risk or severity of adverse effects can be increased when Lenalidomide is combined with Ifosfamide.
Lepirudin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Lepirudin.
Lercanidipine	The metabolism of Ifosfamide can be decreased when combined with Lercanidipine.
Lesinurad	The metabolism of Ifosfamide can be increased when combined with Lesinurad.
Letermovir	The metabolism of Ifosfamide can be decreased when combined with Letermovir.
Letrozole	The metabolism of Ifosfamide can be decreased when combined with Letrozole.
Leuprolide	Leuprolide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Levacetylmethadol	The metabolism of Levacetylmethadol can be increased when combined with Ifosfamide.
Levamlodipine	The serum concentration of Levamlodipine can be increased when it is combined with Ifosfamide.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Levobupivacaine.
Levocarnitine	Levocarnitine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Levocetirizine	Ifosfamide may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Levofloxacin	Levofloxacin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Levoketoconazole	The metabolism of Ifosfamide can be decreased when combined with Levoketoconazole.
Levomilnacipran	The metabolism of Levomilnacipran can be increased when combined with Ifosfamide.
Levonorgestrel	The metabolism of Ifosfamide can be decreased when combined with Levonorgestrel.
Levosalbutamol	Ifosfamide may decrease the excretion rate of Levosalbutamol which could result in a higher serum level.
Levothyroxine	The metabolism of Ifosfamide can be decreased when combined with Levothyroxine.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Lidocaine.
Linagliptin	The metabolism of Ifosfamide can be decreased when combined with Linagliptin.
Linezolid	The risk or severity of adverse effects can be increased when Linezolid is combined with Ifosfamide.
Linzagolix	The serum concentration of Ifosfamide can be increased when it is combined with Linzagolix.
Liothyronine	Liothyronine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Liotrix	The metabolism of Ifosfamide can be decreased when combined with Liotrix.
Lipegfilgrastim	Ifosfamide may increase the myelosuppressive activities of Lipegfilgrastim.
Lisinopril	Lisinopril may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lithium carbonate	Ifosfamide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate	Lithium citrate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lixisenatide	Ifosfamide may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Lofexidine	Ifosfamide may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Lomitapide	The metabolism of Lomitapide can be increased when combined with Ifosfamide.
Lomustine	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Lomustine.
Lonafarnib	The metabolism of Ifosfamide can be decreased when combined with Lonafarnib.
Loperamide	The metabolism of Loperamide can be increased when combined with Ifosfamide.
Lopinavir	The serum concentration of Ifosfamide can be increased when it is combined with Lopinavir.
Loracarbef	Loracarbef may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Loratadine	The metabolism of Ifosfamide can be decreased when combined with Loratadine.
Lorazepam	Lorazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lorcaserin	The metabolism of Ifosfamide can be decreased when combined with Lorcaserin.
Lorlatinib	The metabolism of Ifosfamide can be increased when combined with Lorlatinib.
Lornoxicam	Lornoxicam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lorpiprazole	Ifosfamide may decrease the excretion rate of Lorpiprazole which could result in a higher serum level.
Losartan	The metabolism of Ifosfamide can be decreased when combined with Losartan.
Lovastatin	The metabolism of Lovastatin can be decreased when combined with Ifosfamide.
Loxoprofen	Loxoprofen may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lubiprostone	Lubiprostone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lumacaftor	The metabolism of Ifosfamide can be increased when combined with Lumacaftor.
Lumateperone	The serum concentration of Lumateperone can be decreased when it is combined with Ifosfamide.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Lynestrenol	The metabolism of Lynestrenol can be increased when combined with Ifosfamide.
Macitentan	Ifosfamide may decrease the excretion rate of Macitentan which could result in a higher serum level.
Magnesium	The serum concentration of Magnesium can be decreased when it is combined with Ifosfamide.
Magnesium c	Ifosfamide may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Magnesium chlor	Ifosfamide may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.
Magnesium hydrox	Ifosfamide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium trisil	Ifosfamide may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.
Mangafodipir	Ifosfamide may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Manidipine	The metabolism of Ifosfamide can be decreased when combined with Manidipine.
Mannitol	Mannitol may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline	Maprotiline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Mavacamten	The serum concentration of Ifosfamide can be decreased when it is combined with Mavacamten.
Measles virus vaccine	The therapeutic efficacy of Measles virus vaccine live attenuated can be decreased when used in combination with Ifosfamide.
Mecamylamine	Mecamylamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Mechlorethamine	The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Ifosfamide.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Medroxyprogesterone	The metabolism of Ifosfamide can be increased when combined with Medroxyprogesterone acetate.
Mefenamic acid	Mefenamic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Megestrol acetate	The metabolism of Megestrol acetate can be increased when combined with Ifosfamide.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Meloxicam.
Melphalan	The risk or severity of adverse effects can be increased when Melphalan is combined with Ifosfamide.
Memantine	The metabolism of Ifosfamide can be decreased when combined with Memantine.
Meningococcal	The therapeutic efficacy of Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine can be decreased when used in combination with Ifosfamide.
Meperidine	The metabolism of Ifosfamide can be decreased when combined with Meperidine.
Mephenytoin	The metabolism of Ifosfamide can be decreased when combined with Mephenytoin.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Mepivacaine.
Mepolizumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Mepolizumab.
Meprednisone	The metabolism of Ifosfamide can be increased when combined with Meprednisone.
Mercaptopurine	The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Ifosfamide.
Meropenem	Meropenem may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Mestranol	The metabolism of Mestranol can be increased when combined with Ifosfamide.
Metamfetamine	Ifosfamide may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Metamizole	The risk or severity of myelosuppression can be increased when Metamizole is combined with Ifosfamide.

Metaxalone	Metaxalone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Metformin	Metformin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Methadone	The metabolism of Ifosfamide can be decreased when combined with Methadone.
Methazolamide	Methazolamide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	The metabolism of Ifosfamide can be decreased when combined with Methimazole.
Methotrexate	The metabolism of Methotrexate can be increased when combined with Ifosfamide.
Methoxsalen	The metabolism of Ifosfamide can be decreased when combined with Methoxsalen.
Methoxy	The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Ifosfamide.
Methoxyflurane	The metabolism of Ifosfamide can be decreased when combined with Methoxyflurane.
Methyldopa	Methyldopa may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Methylene blue	The metabolism of Ifosfamide can be decreased when combined with Methylene blue.
Methylergometrine	The metabolism of Ifosfamide can be decreased when combined with Methylergometrine.
Methylnaltrexone	Ifosfamide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Methylphenobarbital	The metabolism of Ifosfamide can be increased when combined with Methylphenobarbital.
Methylprednisolone	The metabolism of Ifosfamide can be increased when combined with Methylprednisolone.
Methylprednisone	The metabolism of Ifosfamide can be decreased when combined with Methylprednisone.
Methyltestosterone	The metabolism of Ifosfamide can be decreased when combined with Methyltestosterone.
Methysergide	The metabolism of Ifosfamide can be decreased when combined with Methysergide.
Meticrane	Meticrane may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Metoclopramide	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Metoclopramide.
Metolazone	Metolazone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Metoprolol	Metoprolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Metreleptin	The metabolism of Ifosfamide can be increased when combined with Metreleptin.
Metronidazole	The metabolism of Ifosfamide can be decreased when combined with Metronidazole.
Metyrapone	The metabolism of Ifosfamide can be increased when combined with Metyrapone.
Mexiletine	The metabolism of Ifosfamide can be decreased when combined with Mexiletine.
Mianserin	The metabolism of Ifosfamide can be decreased when combined with Mianserin.
Miconazole	The metabolism of Ifosfamide can be decreased when combined with Miconazole.
Midazolam	The serum concentration of Midazolam can be increased when it is combined with Ifosfamide.
Midostaurin	The metabolism of Ifosfamide can be increased when combined with Midostaurin.
Mifepristone	The serum concentration of Ifosfamide can be increased when it is combined with Mifepristone.
Migalastat	Ifosfamide may decrease the excretion rate of Migalastat which could result in a higher serum level.
Milnacipran	The metabolism of Milnacipran can be increased when combined with Ifosfamide.
Milrinone	Milrinone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Miocamycin	The metabolism of Ifosfamide can be decreased when combined with Miocamycin.
Mirabegron	Ifosfamide may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Mirtazapine	The metabolism of Ifosfamide can be decreased when combined with Mirtazapine.
Mitapivat	The metabolism of Ifosfamide can be increased when combined with Mitapivat.
Mitomycin	The risk or severity of adverse effects can be increased when Mitomycin is combined with Ifosfamide.
Mitotane	The metabolism of Ifosfamide can be increased when combined with Mitotane.
Mitoxantrone	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Mitoxantrone.
Mobocertinib	The serum concentration of Ifosfamide can be decreased when it is combined with Mobocertinib.
Modafinil	The metabolism of Ifosfamide can be increased when combined with Modafinil.
MCOVID-19 Vaccine	The therapeutic efficacy of Moderna COVID-19 Vaccine can be decreased when used in combination with Ifosfamide.
Modified vaccinia	The therapeutic efficacy of Modified vaccinia ankara can be decreased when used in combination with Ifosfamide.
Mometasone fur	The metabolism of Ifosfamide can be increased when combined with Mometasone furoate.
Monomethyl fuma	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Monomethyl fumarate.
Montelukast	The metabolism of Montelukast can be increased when combined with Ifosfamide.
Morphine	The metabolism of Morphine can be increased when combined with Ifosfamide.
Mosunetuzumab	The metabolism of Ifosfamide can be decreased when combined with Mosunetuzumab.
Moxisylyte	Ifosfamide may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
Mumps virus	The therapeutic efficacy of Mumps virus strain B level jeryl lynn live antigen can be decreased when used in combination with Ifosfamide.
Muromonab	The risk or severity of adverse effects can be increased when Muromonab is combined with Ifosfamide.
Muzolimine	Muzolimine may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Mycophenolate	The metabolism of Ifosfamide can be decreased when combined with Mycophenolate mofetil.
Mycophenolic acid	The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Ifosfamide.
N-acetyltyrosine	Ifosfamide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Nabilone	The metabolism of Ifosfamide can be decreased when combined with Nabilone.
Nabumetone	Nabumetone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nadolol	Ifosfamide may decrease the excretion rate of Nadolol which could result in a higher serum level.
Nadroparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Nadroparin.
Nafcillin	The metabolism of Ifosfamide can be increased when combined with Nafcillin.
Naldemedine	Ifosfamide may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Nalmefene	Ifosfamide may decrease the excretion rate of Nalmefene which could result in a higher serum level.
Naloxone	The metabolism of Ifosfamide can be decreased when combined with Naloxone.
Naproxen	The metabolism of Naproxen can be increased when combined with Ifosfamide.
Natalizumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Natalizumab.
Nateglinide	The metabolism of Ifosfamide can be decreased when combined with Nateglinide.
Nedaplatin	Ifosfamide may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Nedocromil	Nedocromil may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nefazodone	The metabolism of Ifosfamide can be decreased when combined with Nefazodone.
Nelarabine	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Nelarabine.
Nelfinavir	The metabolism of Ifosfamide can be decreased when combined with Nelfinavir.
Neomycin	Ifosfamide may decrease the excretion rate of Neomycin which could result in a higher serum level.
Neratinib	The metabolism of Neratinib can be increased when combined with Ifosfamide.
Netilmicin	Ifosfamide may decrease the excretion rate of Netilmicin which could result in a higher serum level.
Netupitant	The metabolism of Ifosfamide can be decreased when combined with Netupitant.
Nevirapine	The metabolism of Ifosfamide can be decreased when combined with Nevirapine.
Niacin	The metabolism of Ifosfamide can be decreased when combined with Niacin.
Nicardipine	The metabolism of Ifosfamide can be decreased when combined with Nicardipine.
Niclosamide	The metabolism of Niclosamide can be decreased when combined with Ifosfamide.
Nicorandil	Ifosfamide may decrease the excretion rate of Nicorandil which could result in a higher serum level.
Nicotine	The metabolism of Ifosfamide can be decreased when combined with Nicotine.
Nifedipine	The metabolism of Ifosfamide can be increased when combined with Nifedipine.
Nilotinib	The metabolism of Ifosfamide can be decreased when combined with Nilotinib.
Nilutamide	The metabolism of Ifosfamide can be decreased when combined with Nilutamide.
Nilvadipine	The metabolism of Ifosfamide can be decreased when combined with Nilvadipine.
Nimesulide	The risk or severity of bleeding can be increased when Nimesulide is combined with Ifosfamide.
Nintedanib	The metabolism of Ifosfamide can be decreased when combined with Nintedanib.
Nisoldipine	The metabolism of Ifosfamide can be decreased when combined with Nisoldipine.
Nitrendipine	The metabolism of Ifosfamide can be decreased when combined with Nitrendipine.
Nitric Oxide	The risk or severity of methemoglobinemia can be increased when Nitric Oxide is combined with Ifosfamide.
Nitrofurantoin	The risk or severity of methemoglobinemia can be increased when Nitrofurantoin is combined with Ifosfamide.
Nitroglycerin	The risk or severity of methemoglobinemia can be increased when Nitroglycerin is combined with Ifosfamide.
Nitroprusside	The risk or severity of methemoglobinemia can be increased when Nitroprusside is combined with Ifosfamide.
Nitrous oxide	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Nitrous oxide.
Nomegestrol	The metabolism of Nomegestrol can be increased when combined with Ifosfamide.
Nomegestrol	The metabolism of Nomegestrol acetate can be increased when combined with Ifosfamide.
Norelgestromin	The metabolism of Norelgestromin can be increased when combined with Ifosfamide.
Norethisterone	The metabolism of Ifosfamide can be decreased when combined with Norethisterone.

Norethynodrel	The metabolism of Norethynodrel can be increased when combined with Ifosfamide.
Norgestimate	The metabolism of Ifosfamide can be increased when combined with Norgestimate.
Norgestrel	The metabolism of Norgestrel can be increased when combined with Ifosfamide.
Nortriptyline	The metabolism of Nortriptyline can be increased when combined with Ifosfamide.
Noscapine	The metabolism of Ifosfamide can be decreased when combined with Noscapine.
Nuvaxovid	The therapeutic efficacy of Nuvaxovid can be decreased when used in combination with Ifosfamide.
Obinutuzumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Obinutuzumab.
Ocrelizumab	Ocrelizumab may increase the immunosuppressive activities of Ifosfamide.
Octinoxate	Ifosfamide may decrease the excretion rate of Octinoxate which could result in a higher serum level.
Octreotide	The serum concentration of Ifosfamide can be increased when it is combined with Octreotide.
Ofatumumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ofatumumab.
Olanzapine	The metabolism of Ifosfamide can be decreased when combined with Olanzapine.
Olaparib	The metabolism of Olaparib can be increased when combined with Ifosfamide.
Oliceridine	The serum concentration of Oliceridine can be decreased when it is combined with Ifosfamide.
Olodaterol	The metabolism of Olodaterol can be increased when combined with Ifosfamide.
Olsalazine	Olsalazine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ombitasvir	The metabolism of Ombitasvir can be increased when combined with Ifosfamide.
Omeprazole	The metabolism of Ifosfamide can be increased when combined with Omeprazole.
Ondansetron	The metabolism of Ifosfamide can be decreased when combined with Ondansetron.
Opium	Ifosfamide may decrease the excretion rate of Opium which could result in a higher serum level.
Oritavancin	The metabolism of Ifosfamide can be increased when combined with Oritavancin.
Orphenadrine	The metabolism of Ifosfamide can be decreased when combined with Orphenadrine.
Oseltamivir	Oseltamivir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Osilodrostat	The metabolism of Ifosfamide can be decreased when combined with Osilodrostat.
Osimertinib	The metabolism of Osimertinib can be increased when combined with Ifosfamide.
Ospemifene	The metabolism of Ifosfamide can be decreased when combined with Ospemifene.
Ouabain	Ouabain may decrease the cardiotoxic activities of Ifosfamide.
Oxacillin	Oxacillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Oxaliplatin	The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Ifosfamide.
Oxandrolone	The metabolism of Ifosfamide can be decreased when combined with Oxandrolone.
Oxaprozin	Oxaprozin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Oxazepam	Oxazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Oxcarbazepine	The metabolism of Ifosfamide can be increased when combined with Oxcarbazepine.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Oxetacaine.
Oxybenzone	Ifosfamide may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Oxybuprocaine.
Oxybutynin	The metabolism of Ifosfamide can be decreased when combined with Oxybutynin.
Oxycodone	The metabolism of Ifosfamide can be decreased when combined with Oxycodone.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Oxyquinoline	Ifosfamide may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
Ozanimod	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ozanimod.
Paclitaxel	The metabolism of Ifosfamide can be increased when combined with Paclitaxel.
Pacritinib	The serum concentration of Ifosfamide can be increased when it is combined with Pacritinib.
Palbociclib	The metabolism of Palbociclib can be increased when combined with Ifosfamide.
Palifermin	The therapeutic efficacy of Palifermin can be decreased when used in combination with Ifosfamide.
Paliperidone	The metabolism of Ifosfamide can be decreased when combined with Paliperidone.
Palonosetron	Palonosetron may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Panobinostat	The metabolism of Panobinostat can be increased when combined with Ifosfamide.
Pantoprazole	Pantoprazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Paramethadione	The metabolism of Paramethadione can be increased when combined with Ifosfamide.
Parecoxib	Parecoxib may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Paritaprevir	The metabolism of Ifosfamide can be decreased when combined with Paritaprevir.
Parnaparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Parnaparin.
Paromomycin	Paromomycin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Paroxetine	The metabolism of Ifosfamide can be decreased when combined with Paroxetine.
Pasireotide	The metabolism of Ifosfamide can be decreased when combined with Pasireotide.
Patent Blue	Ifosfamide may decrease the excretion rate of Patent Blue which could result in a higher serum level.
Pazopanib	The metabolism of Pazopanib can be increased when combined with Ifosfamide.
Pegaptanib	Ifosfamide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Pegaspargase	The risk or severity of adverse effects can be increased when Pegaspargase is combined with Ifosfamide.
Pegcetacoplan	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Pegcetacoplan.
Peginesatide	The risk or severity of Thrombosis can be increased when Peginesatide is combined with Ifosfamide.
Peginterferon alfa	The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Ifosfamide.
Peginterferon alf	The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Ifosfamide.
Peginterferon bet	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Peginterferon beta-1a.
Pegvisomant	The metabolism of Ifosfamide can be increased when combined with Pegvisomant.
Pemetrexed	The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ifosfamide.
Penbutolol	Ifosfamide may decrease the excretion rate of Penbutolol which could result in a higher serum level.
Penicillamine	The risk or severity of adverse effects can be increased when Penicillamine is combined with Ifosfamide.
Pentaerythritol	Ifosfamide may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
Pentamidine	The metabolism of Ifosfamide can be decreased when combined with Pentamidine.
Pentastarch	Ifosfamide may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Pentetic acid	Ifosfamide may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Pentobarbital	The metabolism of Ifosfamide can be increased when combined with Pentobarbital.
Pentosan polysulfate	The risk or severity of bleeding can be increased when Ifosfamide is combined with Pentosan polysulfate.
Pentostatin	The risk or severity of adverse effects can be increased when Pentostatin is combined with Ifosfamide.
Pentoxifylline	The risk or severity of bleeding can be increased when Pentoxifylline is combined with Ifosfamide.
Perampanel	The metabolism of Ifosfamide can be increased when combined with Perampanel.
Perhexiline	The metabolism of Ifosfamide can be decreased when combined with Perhexiline.
Perindopril	Perindopril may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Permethrin	Ifosfamide may decrease the excretion rate of Permethrin which could result in a higher serum level.
Pertussis vaccine	The therapeutic efficacy of Pertussis vaccine can be decreased when used in combination with Ifosfamide.
Pertuzumab	The risk or severity of cardiotoxicity can be increased when Ifosfamide is combined with Pertuzumab.
Pexidartinib	The metabolism of Pexidartinib can be increased when combined with Ifosfamide.
Phenazopyridine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Phenazopyridine.
Phenelzine	Phenelzine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Phenindione	The risk or severity of bleeding can be increased when Ifosfamide is combined with Phenindione.
Phenobarbital	The metabolism of Ifosfamide can be increased when combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Phenol.
Phenprocoumon	The risk or severity of bleeding can be increased when Ifosfamide is combined with Phenprocoumon.
Phentolamine	Phentolamine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Phenylalanine	The risk or severity of adverse effects can be increased when Phenylalanine is combined with Ifosfamide.
Phenylbutazone	The metabolism of Ifosfamide can be increased when combined with Phenylbutazone.
Phenytoin	The metabolism of Ifosfamide can be increased when combined with Phenytoin.
Pholcodine	Ifosfamide may decrease the excretion rate of Pholcodine which could result in a higher serum level.
Phosphoric acid	Ifosfamide may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
Phylloquinone	Phylloquinone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Picosulfuric acid	Ifosfamide may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level.
Pilocarpine	The metabolism of Ifosfamide can be decreased when combined with Pilocarpine.

Pimavanserin	The metabolism of Ifosfamide can be decreased when combined with Pimavanserin.
Pimecrolimus	The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ifosfamide.
Pimozide	The metabolism of Pimozide can be increased when combined with Ifosfamide.
Pindolol	Pindolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pioglitazone	The metabolism of Pioglitazone can be increased when combined with Ifosfamide.
Piperacillin	Piperacillin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Piperaquine	The metabolism of Ifosfamide can be decreased when combined with Piperaquine.
Piracetam	Ifosfamide may decrease the excretion rate of Piracetam which could result in a higher serum level.
Piretanide	Piretanide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Pirfenidone	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Pirfenidone.
Piroxicam	The metabolism of Piroxicam can be increased when combined with Ifosfamide.
Pitavastatin	The metabolism of Pitavastatin can be increased when combined with Ifosfamide.
Pitolisant	The metabolism of Ifosfamide can be increased when combined with Pitolisant.
Plazomicin	Ifosfamide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Plerixafor	Ifosfamide may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Polythiazide	Polythiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Pomalidomide	The metabolism of Pomalidomide can be increased when combined with Ifosfamide.
Ponatinib	The metabolism of Ponatinib can be increased when combined with Ifosfamide.
Ponesimod	The metabolism of Ifosfamide can be decreased when combined with Ponesimod.
Posaconazole	The metabolism of Ifosfamide can be decreased when combined with Posaconazole.
Potassium	Potassium may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Potassium acetate	Ifosfamide may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
Potassium bicarb	Ifosfamide may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
Potassium cation	Potassium cation may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Potassium chloride	Potassium chloride may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Potassium citrate	Potassium citrate may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Potassium nitrate	Ifosfamide may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
Potassium perchl	Ifosfamide may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
Potassium sulfate	Ifosfamide may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
Pralatrexate	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Pralatrexate.
Pralidoxime	Pralidoxime may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pralsetinib	The metabolism of Ifosfamide can be increased when combined with Pralsetinib.
Pramipexole	Pramipexole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Pramocaine.
Prasugrel	The risk or severity of bleeding can be increased when Ifosfamide is combined with Prasugrel.
Praziquantel	The metabolism of Ifosfamide can be decreased when combined with Praziquantel.
Prednisolone	The metabolism of Ifosfamide can be increased when combined with Prednisolone.
Prednisolone	The metabolism of Ifosfamide can be increased when combined with Prednisolone acetate.
Prednisolone	The metabolism of Ifosfamide can be increased when combined with Prednisolone phosphate.
Prednisone	The risk or severity of adverse effects can be increased when Prednisone is combined with Ifosfamide.
Prednisone	The metabolism of Ifosfamide can be increased when combined with Prednisone acetate.
Pregabalin	Pregabalin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pretomanid	The metabolism of Ifosfamide can be decreased when combined with Pretomanid.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Prilocaine.
Primaquine	The metabolism of Ifosfamide can be decreased when combined with Primaquine.
Primidone	The metabolism of Ifosfamide can be increased when combined with Primidone.
Probenecid	The metabolism of Ifosfamide can be increased when combined with Probenecid.
Procainamide	Ifosfamide may decrease the excretion rate of Procainamide which could result in a higher serum level.
Procaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Procaine.
Procaine be	Ifosfamide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Procarbazine	The risk or severity of adverse effects can be increased when Procarbazine is combined with Ifosfamide.
Progesterone	The metabolism of Ifosfamide can be increased when combined with Progesterone.
Proguanil	The metabolism of Ifosfamide can be decreased when combined with Proguanil.
Promazine	The metabolism of Ifosfamide can be decreased when combined with Promazine.
Promethazine	The metabolism of Ifosfamide can be decreased when combined with Promethazine.
Propantheline	Propantheline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Proparacaine.
Propiverine	Ifosfamide may decrease the excretion rate of Propiverine which could result in a higher serum level.
Propofol	The metabolism of Ifosfamide can be decreased when combined with Propofol.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Propoxycaine.
Propranolol	The metabolism of Ifosfamide can be decreased when combined with Propranolol.
Propylthiouracil	The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Ifosfamide.
Protein C	The risk or severity of bleeding can be increased when Ifosfamide is combined with Protein C.
Protein S human	The risk or severity of bleeding can be increased when Ifosfamide is combined with Protein S human.
Prucalopride	The metabolism of Prucalopride can be decreased when combined with Ifosfamide.
Pyrantel	Ifosfamide may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Pyrazinamide	Pyrazinamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pyridoxine	Pyridoxine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Pyrimethamine	The metabolism of Ifosfamide can be decreased when combined with Pyrimethamine.
Pyrithione	Ifosfamide may decrease the excretion rate of Pyrithione which could result in a higher serum level.
Quazepam	The metabolism of Ifosfamide can be decreased when combined with Quazepam.
Quetiapine	The metabolism of Ifosfamide can be decreased when combined with Quetiapine.
Quinethazone	Quinethazone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine	The metabolism of Quinidine can be increased when combined with Ifosfamide.
Quinine	The metabolism of Ifosfamide can be increased when combined with Quinine.
Quinupristin	The metabolism of Ifosfamide can be decreased when combined with Quinupristin.
Rabeprazole	Rabeprazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Rabies immune	The therapeutic efficacy of Rabies immune globulin, human can be decreased when used in combination with Ifosfamide.
Rabies antigen, A	The therapeutic efficacy of Rabies virus inactivated antigen, A can be decreased when used in combination with Ifosfamide.
Rabies antigen, B	The therapeutic efficacy of Rabies virus inactivated antigen, B can be decreased when used in combination with Ifosfamide.
Raloxifene	The metabolism of Ifosfamide can be decreased when combined with Raloxifene.
Raltitrexed	The risk or severity of adverse effects can be increased when Raltitrexed is combined with Ifosfamide.
Ramelteon	Ramelteon may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ranitidine	Ranitidine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ranolazine	The metabolism of Ranolazine can be increased when combined with Ifosfamide.
Rasagiline	Ifosfamide may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Rasburicase	The risk or severity of methemoglobinemia can be increased when Rasburicase is combined with Ifosfamide.
Ravulizumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ravulizumab.
Regorafenib	The metabolism of Regorafenib can be increased when combined with Ifosfamide.
Relugolix	The metabolism of Ifosfamide can be decreased when combined with Relugolix.
Remdesivir	The metabolism of Ifosfamide can be decreased when combined with Remdesivir.
Repaglinide	The metabolism of Repaglinide can be increased when combined with Ifosfamide.
Reserpine	The metabolism of Ifosfamide can be increased when combined with Reserpine.
Resorcinol	Ifosfamide may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Retapamulin	The metabolism of Retapamulin can be decreased when combined with Ifosfamide.
Reteplase	The risk or severity of bleeding can be increased when Ifosfamide is combined with Reteplase.
Reviparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Reviparin.
Ribavirin	Ribavirin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ribociclib	The metabolism of Ifosfamide can be decreased when combined with Ribociclib.
Ribostamycin	Ifosfamide may decrease the excretion rate of Ribostamycin which could result in a higher serum level.

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Rifabutin	The metabolism of Ifosfamide can be increased when combined with Rifabutin.
Rifampicin	The metabolism of Ifosfamide can be increased when combined with Rifampicin.
Rifamycin	The metabolism of Ifosfamide can be increased when combined with Rifamycin.
Rifapentine	The metabolism of Ifosfamide can be increased when combined with Rifapentine.
Rifaximin	The metabolism of Ifosfamide can be increased when combined with Rifaximin.
Rilonacept	The metabolism of Ifosfamide can be increased when combined with Rilonacept.
Rilpivirine	The serum concentration of Rilpivirine can be decreased when it is combined with Ifosfamide.
Rimegepant	The metabolism of Rimegepant can be increased when combined with Ifosfamide.
Riociguat	The metabolism of Riociguat can be increased when combined with Ifosfamide.
Risankizumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Risankizumab.
Risperidone	The metabolism of Ifosfamide can be decreased when combined with Risperidone.
Ritonavir	The serum concentration of Ifosfamide can be increased when it is combined with Ritonavir.
Rituximab	The risk or severity of adverse effects can be increased when Rituximab is combined with Ifosfamide.
Rivaroxaban	The risk or severity of bleeding can be increased when Ifosfamide is combined with Rivaroxaban.
Rizatriptan	Rizatriptan may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Rofecoxib	The metabolism of Ifosfamide can be increased when combined with Rofecoxib.
Roflumilast	The serum concentration of Roflumilast can be increased when it is combined with Ifosfamide.
Romidepsin	The metabolism of Romidepsin can be increased when combined with Ifosfamide.
Ropeginterfe	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Ropeginterferon alfa-2b.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Ropivacaine.
Rosiglitazone	The metabolism of Rosiglitazone can be increased when combined with Ifosfamide.
Rosuvastatin	The metabolism of Ifosfamide can be decreased when combined with Rosuvastatin.
Rotavirus vaccine	The therapeutic efficacy of Rotavirus vaccine can be decreased when used in combination with Ifosfamide.
Roxadustat	The metabolism of Roxadustat can be increased when combined with Ifosfamide.
Roxithromycin	The metabolism of Ifosfamide can be decreased when combined with Roxithromycin.
Rubella virus	The risk or severity of infection can be increased when Rubella virus vaccine is combined with Ifosfamide.
Rucaparib	The metabolism of Ifosfamide can be decreased when combined with Rucaparib.
Rufinamide	The metabolism of Ifosfamide can be increased when combined with Rufinamide.
Rupatadine	The metabolism of Rupatadine can be decreased when combined with Ifosfamide.
Ruxolitinib	The metabolism of Ruxolitinib can be increased when combined with Ifosfamide.
Sacubitril	Ifosfamide may decrease the excretion rate of Sacubitril which could result in a higher serum level.
Salbutamol	Salbutamol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Salicylamide	Salicylamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Salmeterol	The metabolism of Ifosfamide can be decreased when combined with Salmeterol.
Salmon calcitonin	Salmon calcitonin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Saquinavir	The metabolism of Ifosfamide can be decreased when combined with Saquinavir.
Sarilumab	The metabolism of Ifosfamide can be increased when combined with Sarilumab.
Satralizumab	The serum concentration of Ifosfamide can be decreased when it is combined with Satralizumab.
Saxagliptin	The metabolism of Ifosfamide can be decreased when combined with Saxagliptin.
Secobarbital	The metabolism of Ifosfamide can be increased when combined with Secobarbital.
Secukinumab	The metabolism of Ifosfamide can be increased when combined with Secukinumab.
Segesterone	The metabolism of Segesterone acetate can be increased when combined with Ifosfamide.
Selegiline	The metabolism of Ifosfamide can be decreased when combined with Selegiline.
Selenious acid	Ifosfamide may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Selenium	Ifosfamide may decrease the excretion rate of Selenium which could result in a higher serum level.
Selexipag	The metabolism of Selexipag can be increased when combined with Ifosfamide.
Selpercatinib	The serum concentration of Selpercatinib can be decreased when it is combined with Ifosfamide.
Selumetinib	The metabolism of Ifosfamide can be decreased when combined with Selumetinib.
Sertraline	The metabolism of Ifosfamide can be decreased when combined with Sertraline.
Sevoflurane	The metabolism of Ifosfamide can be decreased when combined with Sevoflurane.
Sibutramine	Sibutramine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Sildenafil	The metabolism of Ifosfamide can be decreased when combined with Sildenafil.
Siltuximab	The metabolism of Ifosfamide can be increased when combined with Siltuximab.
Simeprevir	The metabolism of Ifosfamide can be decreased when combined with Simeprevir.
Simvastatin	The metabolism of Ifosfamide can be decreased when combined with Simvastatin.
Siponimod	The metabolism of Siponimod can be increased when combined with Ifosfamide.
Sipuleucel-T	The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Ifosfamide.
Sirolimus	The metabolism of Sirolimus can be increased when combined with Ifosfamide.
Sitagliptin	The metabolism of Sitagliptin can be increased when combined with Ifosfamide.
Sitaxentan	The metabolism of Ifosfamide can be decreased when combined with Sitaxentan.
Smallpox	The therapeutic efficacy of Smallpox (Vaccinia) Vaccine, Live can be decreased when used in combination with Ifosfamide.
Sodium acetate	Ifosfamide may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
Sodium aurothio	Ifosfamide may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Sodium citrate	The risk or severity of bleeding can be increased when Ifosfamide is combined with Sodium citrate.
Sodium fluoride	Ifosfamide may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Sodium sulfate	Ifosfamide may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
Sofosbuvir	Ifosfamide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Solriamfetol	Ifosfamide may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Somatostatin	The metabolism of Ifosfamide can be decreased when combined with Somatostatin.
Somatrogon	The metabolism of Ifosfamide can be increased when combined with Somatrogon.
Sonidegib	The metabolism of Sonidegib can be increased when combined with Ifosfamide.
Sorafenib	The metabolism of Sorafenib can be increased when combined with Ifosfamide.
Sorbitol	Ifosfamide may decrease the excretion rate of Sorbitol which could result in a higher serum level.
Sotorasib	The serum concentration of Ifosfamide can be decreased when it is combined with Sotorasib.
Spesolimab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Spesolimab.
Spironolactone	The metabolism of Ifosfamide can be decreased when combined with Spironolactone.
St. John’s Wort	The metabolism of Ifosfamide can be increased when combined with St. John’s Wort.
Stiripentol	The metabolism of Ifosfamide can be decreased when combined with Stiripentol.
Streptokinase	The risk or severity of bleeding can be increased when Ifosfamide is combined with Streptokinase.
Streptomycin	Ifosfamide may decrease the excretion rate of Streptomycin which could result in a higher serum level.
Streptozocin	The risk or severity of adverse effects can be increased when Streptozocin is combined with Ifosfamide.
Strontium chloride	Ifosfamide may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Sucralfate	Sucralfate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Sulbactam	Ifosfamide may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Sulfadiazine	The risk or severity of methemoglobinemia can be increased when Sulfadiazine is combined with Ifosfamide.
Sulfamethizole	The metabolism of Ifosfamide can be decreased when combined with Sulfamethizole.
Sulfamethoxazole	The risk or severity of myelosuppression can be increased when Sulfamethoxazole is combined with Ifosfamide.
Sulfaphenazole	The metabolism of Ifosfamide can be decreased when combined with Sulfaphenazole.
Sulfapyridine	The risk or severity of methemoglobinemia can be increased when Sulfapyridine is combined with Ifosfamide.
Sulfasalazine	The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Ifosfamide.
Sulfinpyrazone	The metabolism of Ifosfamide can be increased when combined with Sulfinpyrazone.
Sulfisoxazole	The metabolism of Ifosfamide can be decreased when combined with Sulfisoxazole.
Sulindac	Sulindac may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Sulodexide	The risk or severity of bleeding can be increased when Ifosfamide is combined with Sulodexide.
Sumatriptan	Sumatriptan may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Sunitinib	The metabolism of Sunitinib can be increased when combined with Ifosfamide.
Suvorexant	The metabolism of Ifosfamide can be decreased when combined with Suvorexant.

Tacrolimus	The serum concentration of Tacrolimus can be increased when it is combined with Ifosfamide.
Tadalafil	The metabolism of Ifosfamide can be decreased when combined with Tadalafil.
Tamoxifen	The metabolism of Ifosfamide can be increased when combined with Tamoxifen.
Tamsulosin	Tamsulosin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tasimelteon	The metabolism of Ifosfamide can be decreased when combined with Tasimelteon.
Tazarotene	The metabolism of Tazarotene can be increased when combined with Ifosfamide.
Tazemetostat	The metabolism of Ifosfamide can be decreased when combined with Tazemetostat.
Technetium	Ifosfamide may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
Technetium	Ifosfamide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Technetium T	Ifosfamide may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level.
Technetium Tc	Ifosfamide may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
Tecovirimat	The metabolism of Ifosfamide can be increased when combined with Tecovirimat.
Tedizolid phos	The risk or severity of myelosuppression can be increased when Ifosfamide is combined with Tedizolid phosphate.
Teduglutide	Ifosfamide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tegafur	The metabolism of Tegafur can be decreased when combined with Ifosfamide.
Tegafur-uracil	The metabolism of Tegafur-uracil can be decreased when combined with Ifosfamide.
Tegaserod	The metabolism of Ifosfamide can be decreased when combined with Tegaserod.
Telaprevir	The metabolism of Ifosfamide can be decreased when combined with Telaprevir.
Telavancin	Ifosfamide may decrease the excretion rate of Telavancin which could result in a higher serum level.
Telithromycin	The metabolism of Ifosfamide can be decreased when combined with Telithromycin.
Telotristat ethyl	The serum concentration of Ifosfamide can be decreased when it is combined with Telotristat ethyl.
Temazepam	Temazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Temozolomide	The risk or severity of adverse effects can be increased when Temozolomide is combined with Ifosfamide.
Temsirolimus	The metabolism of Temsirolimus can be increased when combined with Ifosfamide.
Tenecteplase	The risk or severity of bleeding can be increased when Ifosfamide is combined with Tenecteplase.
Teniposide	The metabolism of Teniposide can be increased when combined with Ifosfamide.
Tenofovir a	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Ifosfamide.
Tenofovir dis	Tenofovir disoproxil may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tenoxicam	Tenoxicam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tepotinib	The metabolism of Ifosfamide can be decreased when combined with Tepotinib.
Teprotumumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Teprotumumab.
Terbinafine	The metabolism of Ifosfamide can be increased when combined with Terbinafine.
Terbutaline	Terbutaline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Terfenadine	The metabolism of Ifosfamide can be decreased when combined with Terfenadine.
Teriflunomide	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Teriflunomide.
Testolactone	Testolactone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Testosterone	The metabolism of Ifosfamide can be increased when combined with Testosterone.
Testosterone	The metabolism of Ifosfamide can be increased when combined with Testosterone cypionate.
Testosterone	The metabolism of Ifosfamide can be increased when combined with Testosterone enanthate.
Testosterone pro	Ifosfamide may decrease the excretion rate of Testosterone propionate which could result in a higher serum level.
Testosterone unde	The metabolism of Ifosfamide can be increased when combined with Testosterone undecanoate.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Ifosfamide is combined with Tetracaine.
Tetracycline	The metabolism of Ifosfamide can be decreased when combined with Tetracycline.
Tetradecyl	Ifosfamide may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
Tezacaftor	The metabolism of Ifosfamide can be decreased when combined with Tezacaftor.
Thalidomide	The risk or severity of adverse effects can be increased when Thalidomide is combined with Ifosfamide.
Theophylline	The metabolism of Theophylline can be increased when combined with Ifosfamide.
Thiabendazole	Thiabendazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Thiamylal	The metabolism of Ifosfamide can be increased when combined with Thiamylal.
Thiethylperazine	Thiethylperazine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Thiopental	The metabolism of Ifosfamide can be increased when combined with Thiopental.
Thiosulfuric acid	The metabolism of Ifosfamide can be increased when combined with Thiosulfuric acid.
Thiotepa	The metabolism of Thiotepa can be increased when combined with Ifosfamide.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Ticagrelor	The risk or severity of bleeding can be increased when Ifosfamide is combined with Ticagrelor.
Tick encephalitis	The therapeutic efficacy of Tick-borne encephalitis vaccine (whole virus, inactivated) can be decreased when used in combination with Ifosfamide.
Ticlopidine	The metabolism of Ifosfamide can be decreased when combined with Ticlopidine.
Tiludronic acid	Tiludronic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Timolol	Timolol may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tinidazole	Tinidazole may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tinzaparin	The risk or severity of bleeding can be increased when Ifosfamide is combined with Tinzaparin.
Tioguanine	The risk or severity of adverse effects can be increased when Tioguanine is combined with Ifosfamide.
Tiopronin	Ifosfamide may decrease the excretion rate of Tiopronin which could result in a higher serum level.
Tiotropium	Ifosfamide may decrease the excretion rate of Tiotropium which could result in a higher serum level.
Tipranavir	The metabolism of Ifosfamide can be decreased when combined with Tipranavir.
Tirofiban	The risk or severity of bleeding can be increased when Tirofiban is combined with Ifosfamide.
Tivozanib	The metabolism of Tivozanib can be increased when combined with Ifosfamide.
Tixocortol	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Tixocortol.
Tobramycin	Ifosfamide may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Tocilizumab	The metabolism of Ifosfamide can be increased when combined with Tocilizumab.
Tocopherol	Ifosfamide may decrease the excretion rate of Tocopherol which could result in a higher serum level.
Tofacitinib	The metabolism of Tofacitinib can be decreased when combined with Ifosfamide.
Tolazamide	Tolazamide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tolbutamide	The metabolism of Tolbutamide can be increased when combined with Ifosfamide.
Tolcapone	Tolcapone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tolfenamic acid	Tolfenamic acid may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tolterodine	Tolterodine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Tolvaptan	The metabolism of Tolvaptan can be increased when combined with Ifosfamide.
Topiramate	The metabolism of Ifosfamide can be increased when combined with Topiramate.
Topotecan	The risk or severity of adverse effects can be increased when Topotecan is combined with Ifosfamide.
Torasemide	Torasemide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Tositumomab	The risk or severity of adverse effects can be increased when Tositumomab is combined with Ifosfamide.
Trabectedin	The metabolism of Trabectedin can be increased when combined with Ifosfamide.
Tramadol	The metabolism of Tramadol can be decreased when combined with Ifosfamide.
Trametinib	The metabolism of Ifosfamide can be increased when combined with Trametinib.
Tranylcypromine	The metabolism of Ifosfamide can be decreased when combined with Tranylcypromine.
Trastuzumab	Trastuzumab may increase the neutropenic activities of Ifosfamide.
Trastuzumab	The metabolism of Trastuzumab emtansine can be increased when combined with Ifosfamide.
Trazodone	The metabolism of Ifosfamide can be decreased when combined with Trazodone.
Treprostinil	The metabolism of Treprostinil can be increased when combined with Ifosfamide.
Tretinoin	The metabolism of Ifosfamide can be decreased when combined with Tretinoin.
Triamcinolone	The metabolism of Ifosfamide can be increased when combined with Triamcinolone.
Triamterene	Triamterene may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam	The metabolism of Ifosfamide can be decreased when combined with Triazolam.
Trichlormethiazide	Trichlormethiazide may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Triclabendazole	The metabolism of Ifosfamide can be decreased when combined with Triclabendazole.
Triethylenetetramine	Ifosfamide may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
Trifluridine	The risk or severity of adverse effects can be increased when Trifluridine is combined with Ifosfamide.

Trilostane	The risk or severity of adverse effects can be increased when Trilostane is combined with Ifosfamide.
Trimebutine	Ifosfamide may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Trimethadione	The metabolism of Trimethadione can be increased when combined with Ifosfamide.
Trimethoprim	The metabolism of Ifosfamide can be decreased when combined with Trimethoprim.
Trimetrexate	Trimetrexate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Trimipramine	The metabolism of Ifosfamide can be decreased when combined with Trimipramine.
Troglitazone	The metabolism of Ifosfamide can be increased when combined with Troglitazone.
Troleandomycin	The metabolism of Ifosfamide can be decreased when combined with Troleandomycin.
Tropisetron	Ifosfamide may decrease the excretion rate of Tropisetron which could result in a higher serum level.
Tucatinib	The metabolism of Tucatinib can be decreased when combined with Ifosfamide.
Typhoid vaccine	The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Ifosfamide.
Typhoid Vaccine	The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Ifosfamide.
Typhoid Vi p	The therapeutic efficacy of Typhoid Vi polysaccharide vaccine can be decreased when used in combination with Ifosfamide.
Udenafil	The metabolism of Ifosfamide can be decreased when combined with Udenafil.
Ulipristal	The metabolism of Ulipristal can be increased when combined with Ifosfamide.
Upadacitinib	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Upadacitinib.
Urokinase	The risk or severity of bleeding can be increased when Ifosfamide is combined with Urokinase.
Vaborbactam	Ifosfamide may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
Valaciclovir	Valaciclovir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Valbenazine	The metabolism of Ifosfamide can be decreased when combined with Valbenazine.
Valdecoxib	Valdecoxib may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Valganciclovir	Ifosfamide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Valproic acid	The metabolism of Ifosfamide can be decreased when combined with Valproic acid.
Valsartan	The metabolism of Ifosfamide can be decreased when combined with Valsartan.
Vancomycin	Ifosfamide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Vandetanib	The metabolism of Vandetanib can be increased when combined with Ifosfamide.
Vardenafil	The metabolism of Vardenafil can be decreased when combined with Ifosfamide.
Varenicline	Ifosfamide may decrease the excretion rate of Varenicline which could result in a higher serum level.
Varicella zoster	The risk or severity of infection can be increased when Varicella zoster vaccine (live/attenuated) is combined with Ifosfamide.
Varicella zoster	The therapeutic efficacy of Varicella zoster vaccine (recombinant) can be decreased when used in combination with Ifosfamide.
Vasopressin	Ifosfamide may increase the fluid retaining and vasopressor activities of Vasopressin.
Vedolizumab	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Vedolizumab.
Velpatasvir	The metabolism of Ifosfamide can be decreased when combined with Velpatasvir.
Vemurafenib	The metabolism of Ifosfamide can be increased when combined with Vemurafenib.
Venetoclax	The metabolism of Venetoclax can be increased when combined with Ifosfamide.
Venlafaxine	Venlafaxine may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Verapamil	The metabolism of Ifosfamide can be decreased when combined with Verapamil.
Vibrio cholerae	The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Ifosfamide.
Vilanterol	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Vilanterol.
Viloxazine	The metabolism of Ifosfamide can be decreased when combined with Viloxazine.
Vinblastine	The metabolism of Ifosfamide can be increased when combined with Vinblastine.
Vincristine	The metabolism of Vincristine can be increased when combined with Ifosfamide.
Vindesine	The metabolism of Vindesine can be increased when combined with Ifosfamide.
Vinflunine	The metabolism of Vinflunine can be increased when combined with Ifosfamide.
Vinorelbine	The metabolism of Vinorelbine can be increased when combined with Ifosfamide.
Vismodegib	The metabolism of Vismodegib can be decreased when combined with Ifosfamide.
Vitamin E	The metabolism of Ifosfamide can be increased when combined with Vitamin E.
Voclosporin	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Voclosporin.
Vonoprazan	The metabolism of Ifosfamide can be decreased when combined with Vonoprazan.
Vorapaxar	The risk or severity of bleeding can be increased when Ifosfamide is combined with Vorapaxar.
Voriconazole	The metabolism of Ifosfamide can be decreased when combined with Voriconazole.
Vorinostat	The risk or severity of adverse effects can be increased when Ifosfamide is combined with Vorinostat.
Vortioxetine	The metabolism of Ifosfamide can be decreased when combined with Vortioxetine.
Voxelotor	The serum concentration of Ifosfamide can be increased when it is combined with Voxelotor.
Voxilaprevir	The metabolism of Voxilaprevir can be increased when combined with Ifosfamide.
Warfarin	The metabolism of Ifosfamide can be increased when combined with Warfarin.
Ximelagatran	The risk or severity of bleeding can be increased when Ifosfamide is combined with Ximelagatran.
Yellow fever	The risk or severity of infection can be increased when Yellow fever vaccine is combined with Ifosfamide.
Zafirlukast	The metabolism of Ifosfamide can be decreased when combined with Zafirlukast.
Zaleplon	The metabolism of Ifosfamide can be decreased when combined with Zaleplon.
Zanamivir	Zanamivir may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Zanubrutinib	The metabolism of Zanubrutinib can be increased when combined with Ifosfamide.
Zidovudine	The risk or severity of adverse effects can be increased when Zidovudine is combined with Ifosfamide.
Zileuton	The metabolism of Ifosfamide can be decreased when combined with Zileuton.
Zimelidine	The metabolism of Ifosfamide can be decreased when combined with Zimelidine.
Ziprasidone	The metabolism of Ifosfamide can be decreased when combined with Ziprasidone.
Zolpidem	The metabolism of Zolpidem can be increased when combined with Ifosfamide.
Zonisamide	The metabolism of Ifosfamide can be decreased when combined with Zonisamide.
Zopiclone	The metabolism of Zopiclone can be decreased when combined with Ifosfamide.
Zuclopenthixol	The metabolism of Ifosfamide can be decreased when combined with Zuclopenthixol.

Pregnancy and Lactation

AU TGA pregnancy category: D
US FDA pregnancy category: Not assigned.

Pregnancy

This drug can cause fetal harm when administered to a pregnant woman. Fetal growth retardation and neonatal anemia have been reported. Adequate methods of contraception should be encouraged. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus. Women should not become pregnant during therapy. Men should not father a child during therapy and for up to 6 months after. Animal studies have revealed evidence of embryotoxicity, gene mutations, and chromosomal damage. There are no controlled data on human pregnancy.

Lactation

Use is contraindicated.
Excreted into human milk: Yes
This drug is tumorigenic and can harm a nursing infant.

How should this medicine be used?

Ifosfamide comes as a powder to be mixed with liquid to be injected over at least 30 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. It may be injected once a day for 5 days in a row. This treatment may be repeated every 3 weeks. The length of treatment depends on how well your body responds to treatment with ifosfamide.

Your doctor may need to delay your treatment if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with ifosfamide.

Ifosfamide is also sometimes used to treat bladder cancer, lung cancer, cancer of the ovaries (cancer that begins in the female reproductive organs where eggs are formed), cancer of the cervix, and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving ifosfamide,

tell your doctor and pharmacist if you are allergic to ifosfamide, cyclophosphamide (Cytoxan), any other medications, or any of the ingredients in the ifosfamide injection. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins and nutritional supplements you are receiving or plan to take. Be sure to mention the medication listed in the IMPORTANT WARNING section and any of the following: aprepitant (Emend); certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); certain seizure medications such as carbamazepine (Tegretol), phenobarbital (Luminal), and phenytoin (Dilantin); medications for allergies or hay fever; medications for nausea; opioid (narcotic) medications for pain; rifampin (Rifadin, Rimactane); sedatives; sleeping pills; or sorafenib (Nexavar). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with ifosfamide, so be sure to tell your doctor about all the medications you are receiving, even those that do not appear on this list.
tell your doctor what herbal products you are receiving, especially St. John’s wort.
tell your doctor if you have previously received treatment with other chemotherapy medications or if you have previously received radiation therapy. Also tell your doctor if you have or have ever had heart, kidney, or liver disease.
you should know that ifosfamide may slow the healing of wounds.
you should know that ifosfamide may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. Ifosfamide may cause permanent infertility (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breastfeeding should tell their doctors before they begin receiving this drug. You should not become pregnant or breast-feed while you are receiving ifosfamide. Use a reliable method of birth control to prevent pregnancy while you are receiving ifosfamide and for 6 months after treatments. If you are male, you and your female partner should continue to use birth control for 6 months after you stop receiving ifosfamide injections. If you become pregnant while receiving ifosfamide, call your doctor immediately. Ifosfamide may harm the fetus.

References

Ifosfamide – Uses, Dosage, Side Effects, Interaction

Mechanism of Action